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Wada Keiji  和田 圭司

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WADA Keiji  和田 圭司

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Researcher Number 70250222
Other IDs
Affiliation (Current) 2025: 国立研究開発法人国立精神・神経医療研究センター, その他部局等, 顧問
Affiliation (based on the past Project Information) *help 2018 – 2019: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所, 所長
2017: 国立研究開発法人国立精神・神経医療研究センター, トランスレーショナル・メディカルセンター, センター長
2015: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 部長
2012 – 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 部長
2012: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第4部, 部長 … More
2012: 独立行政法人国立精神, 神経医療センター, 疾病研究第4部.部長
2012: 独立行政法人国立精神・神経医療研究センター, その他部局等, その他
2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所 疾病研究第四部, 部長
2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所・疾病研究第4部, 部長
2010: National Center of Neurology and Psychiatry, 神経研究所疾病研究第4部, 部長
2010: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 部長
2009: National Center of Neurology and Psychiatry, 神経研究所・疾病研究第4部, 部長
2009: National Center of Neurology and Psychiatry, 神経研究所・疾病研究第四部, 部長
2006 – 2008: National Institute of Neuroscience, Department of Degenerative Neurological Diseases, Director, 神経研究所疾病研究第四部, 部長
2006 – 2008: 国立精神神経センター, 神経研究所, 部長
2007: National Center of Neurology and Psychiatry, 神経研究所・疾病研究第四部, 部長
2005: 国立精神・神経センター, 神経研究所, 部長
2005: National Center of Neurology and Psychiatry, National Institute of Neuroscience, Head, 神経研究所・疾病研究第4部, 部長
2003 – 2005: National Center of Neurology and Psychiatry, National Institute of Neuroscience, Department of Degenerative Neurological Diseases, Director, 疾病研究第四部, 部長
2004: 国立精神・神経センター, 神経研究所, 部長(研究職)
2003: 国立精神・神経センター, 疾病研究第4部, 部長
2002: National Center of Neurology and Phychiatry, National Institute of Neuroscience, Director, 神経研究所・疾病研究第4部, 部長(研究職)
2002: Department of Degenerative Neurological Diseases, Director, 神経研究所・疾病研究第四部, 部長
1999 – 2002: National Institute of Neuroscience, Department of Degenerative Neurological Diseases, Director, 神経研究所・疾病研究第4部, 部長
2001: 国立精神・神経センター, 神経研究所・疫病研究第四部, 部長
2000: National Institute of Neuroscience, Department of Degenerative Neurological Diseases, Director, 神経研究所疾病研究第4部, 部長
1998: 国立精神, 神経センター神経研究所疾病4部, 部長
1998: 国立精神・神経センター, 神経研究所疾病研究第4部, 部長
1998: 国立精神・神経センター, 神経研究疾病研究第4部, 部長
1997: 国立精神, 神経センター・神経研究所・疾病研究第四部, 部長
1997: Natl.Inst.Neurosci., Dept.Neurochemistry, Director, 神経センター神経研究所・疾病研究第四部, 部長
1994 – 1997: 国立精神・神経センター, 神経研究所・疾病研究第4部, 部長
1996: 国立精神, 神経センター・神経研究所・疾病研究第3部, 部長
1995: 国立精神, 神経センター・神経研究所・疾病研究第4部, 部長
1995: 国立精神, 神経センター・神経研究所・疾病研究第四部, 部長
1993: 国立精神・神経センター, 神経研究所疾病研究第4部, 部長 Less
Review Section/Research Field
Principal Investigator
Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Biological Sciences / Neurochemistry/Neuropharmacology / Biological Sciences / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology
Except Principal Investigator
Biological pharmacy / Neurochemistry/Neuropharmacology / Psychiatric science / Neurology / Living organism molecular science
Keywords
Principal Investigator
マウス / ユビキチン / 疾患モデルマウス / グルタミン酸 / オートファジー / 酸化ストレス / 脱ユビキチン化酵素 / 神経細胞 / シナプス / パーキンソン病 … More / 軸索変性 / 分子遺伝学 / ポジショナルクローニング / synapse / ubiquitin / 神経細胞死 / 受容体 / スパイン / 脳機能発達 / 母体 / トランスポーター / 運動失調 / 連鎖解析 / neuroregeneration / neurotransmission / neuron / protein degradation / mouse / 神経再生 / 神経伝達 / 蛋白分解 / receptor / 網膜 / 情動 / 脂質 / 脂肪酸 / 機能形態学 / 栄養 / 酵素 / 遺伝子 / ミクログリア / グリア / 電気生理学 / 分子生物学 / 発生工学 / 記憶・学習 / 神経伝達物質受容体 / 予防 / 脂質代謝 / リソソーム / 脳・神経 / deubiquitinating enzyme / 神経発生 / ミトコンドリア / アポトーシス / ALS / parkin / neurodegeneration / 神経軸索 / 幹細胞 / 神経変性 / olfaction / emotional behavior / abnormal behavior / knockout mouse / obesity / bombesin / bioactive peptide / 視床下部 / 神経ペプチド / 味覚 / 嗅覚 / 行動異常 / 遺伝子欠損マウス / 肥満 / ボンベシン / 生理活性ペプチド / retina / transporter / glutamate / gene / glia / ATP / プラスミノーゲン / けいれん / 脱感作 / 変性 / 軸索 / p75 / trkC / FGF / 神経栄養因子 / ラット / 光変性 / medicine / NMDA receptor / glutamate receptor / D-serine / amino acid / motor ataxia / spinocerebellar degeneration / animal model / 治療薬 / NMDA受容体 / グルタミン酸受容体 / Dセリン / アミノ酸 / 脊髄小脳変性症 / 不安 / 核酸 / LAMP2 / 生活習慣 / 高脂肪食 / 不飽和脂肪酸 / 胎盤 / 授乳 / 脳科学 / モデル動物 / 分泌 / 生体情報 / ネットワーク / 組織 / 細胞 / 生理活性 / 神経科学 / 脳神経疾患 / 蛋白質 / 顕微鏡 / 免疫沈降 / チューブリン / 蛋白質相互作用 / 脂肪細胞 / GAPDH / 脂肪 / 創薬 / シヌクレイン / ビタミンE / 代謝 / 薬剤開発 / ミエリン / 恐怖条件付け / ニューロテンシン / 扁桃体 / 多様性 / PACAP / ブラジキニン / VIP / アストロサイト / G蛋白質共役型受容体 / 遣伝子 / 遺伝性疾患 / 末梢神経 / 運動感覚神経ニューロパチー / 髄鞘 / 相同組み換え体 / プロモーター / in situ hybridization / mRNA / 遺伝子クローニング … More
Except Principal Investigator
ミクログリア / 神経変性疾患 / microglia / 一酸化窒素 / ブラジキニン / 腫瘍壊死因子 / パッチクランプ / 脳 / PEPA / アストロサイト / グルタミン酸 / cytokine / B1 receptor / chemotaxis / motility / neuroprotection / bradykinin / inflammation / プロスタグランジン / サイトカイン / B1受容体 / 化学走性 / 遊走性 / 神経保護作用 / 炎症 / psychological disorder / signal transduction / 5-HT_<5A> receptors / brain injury / bradkinin receptor / glutamate receptor / neuroprotective drug / 炎症性メディエーター / 神経傷害 / 受容体 / ニューロン / 精神疾患 / シグナル伝達系 / 5-HT5A受容体 / 脳傷害 / ブラジキニン受容体 / グルタミン酸受容体 / 記憶障害改善薬 / L-Serine / Glycine / Binding sites / Biosynthesis / Uptake / Extracellular release / Mammalian brains / Endogenous D-serine / 脳内濃度調節 / 結合活性 / 取り込み活性 / 細胞外液中への放出 / 非NMDA受容体D-セリン結合部位 / L-セリン代謝 / グリシン代謝 / グリシン開裂酵素 / NMDA受容体チャンネル / 哺乳類 / D-セリン合成 / GABA伝達系 / グリア細胞 / 内在性D-セリン / L-セリン / グリシン / 結合部位 / 生合成 / 取り込み / 細胞外放出 / 内存性D-セリン / RNA代謝 / 神経変性 / 前頭側頭葉変性症 / 筋委縮性側索硬化症 / 細胞死 / 酸化ストレス / ストレス顆粒 / TDP-43 / 前頭側頭型認知症 / 筋萎縮性側索硬化症 / 神経科学 / 湾曲化完全結晶 / 中間領域散乱 / 溶液散乱解析 / タンパク質溶液散乱 / 中性子広角散乱 / シヌクレイン / パーキンソン病 / 中性子モノクロメータ / 中性子小角散乱 / 中性子散乱 / 動的光散乱 / 機器分析 / カルシウム / グリア / 神経細胞死 / 神経伝達物質 / シナプス伝達 / トサンスポーター Less
  • Research Projects

    (26 results)
  • Research Products

    (116 results)
  • Co-Researchers

    (22 People)
  •  Control of lipid metabolism by a novel autophagic system for the prevention of neurodegenerative disordersPrincipal Investigator

    • Principal Investigator
      Wada Keiji
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  母体の食変化と子の脳機能発達に関する病態神経科学研究Principal Investigator

    • Principal Investigator
      和田 圭司
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Regulation of higher brain function by lipid metabolismPrincipal Investigator

    • Principal Investigator
      Wada Keiji
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  母体の食変化と子の脳機能発達に関する病態神経科学研究Principal Investigator

    • Principal Investigator
      和田 圭司
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Study on the role of extracellular deubiquitinating enzymesPrincipal Investigator

    • Principal Investigator
      WADA Keiji
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Investigation of effect of TDP-43 aggregation on translational control

    • Principal Investigator
      HIGASHI Shinji
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      公益財団法人東京都医学総合研究所
      Tokyo Metropolitan Organization for Medical Research
  •  Regulation of neuronal cell function organized by deubiquitinating enzymesPrincipal Investigator

    • Principal Investigator
      WADA Keiji
    • Project Period (FY)
      2007 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Structural study of Parkinson disease related protein by intermediate region neutron scattering method

    • Principal Investigator
      FURUSAKA Michihiro, 内藤 幸雄
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Living organism molecular science
    • Research Institution
      Hokkaido University
      High Energy Accelerator Research Organization
  •  DYNAMIC REGULATION OF THE MAINTENANCE AND FUNCTION OF NEURAL CELLS BY THE UBIOUITIN SYSTEMPrincipal Investigator

    • Principal Investigator
      WADA Keiji
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      National Institute of Neuroscience, National Center of Neurology and Psychiatry
  •  Establishment of new kinin-network via microglia in the central nervous system

    • Principal Investigator
      NODA Mami
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      KYUSHU UNIVERSITY
  •  疾患モデル動物を用いたグリア・ニューロン相互作用の解析Principal Investigator

    • Principal Investigator
      和田 圭司
    • Project Period (FY)
      2003 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Center of Neurology and Psychiatry
  •  ELUCIDATION OF THE MAINTENANCE MECHANISM OF SYNAPTIC STRUCTURE AND FUNCTION BY THE PROTEIN QUALTY CONTROL SYSTEM AND ITS APPLICATION TO NEUROREGENERATIONPrincipal Investigator

    • Principal Investigator
      WADA Keiji
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      National Center of Neurology and Psychiatry (NCNP)
  •  Molecular analyses of neuron-astrocyte-microglia network

    • Principal Investigator
      NODA Mami
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kyushu University
  •  グリア細胞グルタミン酸受容体と神経細胞死防御機構

    • Principal Investigator
      SEKIGUCHI Masayuki
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Investigation on the regulation of synaptic transmission by glial moleculesPrincipal Investigator

    • Principal Investigator
      WADA Keiji
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (B)
    • Review Section
      Biological Sciences
    • Research Institution
      National Center of Neurology and Psychiatry
  •  INVESTIGATION ON PHYSIOLOGICAL ROLE OF BOMBESIN-LIKE PEPTIDE RECEPTOR SYSTEM IN BRAINPrincipal Investigator

    • Principal Investigator
      WADA Keiji
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      National Institute of Neuroscience, National Center of Neurology and Psychiatry
  •  EXPLORATORY STUDY FOR ESTABLISHING A NEW THERAPY WITH ENDOGENOUS D-AMINO ACIDS IN MOTOR ATAXIAPrincipal Investigator

    • Principal Investigator
      WADA Keiji
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      National Institute of Neuroscience, National Center of Neurology and Psychiatry
  •  神経細胞・神経軸索機能維持因子の同定と機能解析Principal Investigator

    • Principal Investigator
      和田 圭司
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Center of Neurology and Psychiatry
  •  新しい遺伝子変異に基づく髄鞘形成異常の解析と神経伝達の機能的再生にむけた技術開発Principal Investigator

    • Principal Investigator
      和田 圭司
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      National Center of Neurology and Psychiatry
  •  モデル動物を用いた神経細胞・神経軸索機能維持因子遺伝子の単離Principal Investigator

    • Principal Investigator
      和田 圭司
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Center of Neurology and Psychiatry
  •  グルタミン酸トランスポーターの生理学的・病態生理学的役割の解明

    • Principal Investigator
      田中 光一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Center of Neurology and Psychiatry
  •  ニューロンの興奮性・抑制性の選択を決定する分子機構の解明Principal Investigator

    • Principal Investigator
      和田 圭司
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Metabolism and Physiological functions of endogenous D-serine

    • Principal Investigator
      NISHIKAWA Toru
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Psychiatric science
    • Research Institution
      National Institute of Neuroscience, NCNP
  •  シナプス機能におけるグリア由来AMPA受容体の役割についての発生工学的解析Principal Investigator

    • Principal Investigator
      和田 圭司
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Center of Neurology and Psychiatry
  •  モデル動物を用いた神経細胞・神経軸索機能維持因子の同定Principal Investigator

    • Principal Investigator
      和田 圭司
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Center of Neurology and Psychiatry
  •  蛋白質レベルでのターゲッティングによるグルタミン酸レセプター機能低下マウスの開発Principal Investigator

    • Principal Investigator
      和田 圭司
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Center of Neurology and Psychiatry

All 2020 2018 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

  • [Book] 脳の脱ユビキチン化酵素活性のユビキチン単量体と二量体による調節2009

    • Author(s)
      和田圭司、節家理恵子
    • Publisher
      生体の科学
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Book] UCH-L1(67 Suppl 4)2009

    • Author(s)
      和田圭司、株田智弘
    • Publisher
      日本臨床
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Book] Asian Symposium for Pharmaceutical Science in JSPS Asian Core Program2006

    • Author(s)
      Noda, M., Ifuku, M., Farber, K., Seike, T., Wang, B., Kettenmann, H., Wada, K.
    • Total Pages
      3
    • Publisher
      Kyushu University
    • Data Source
      KAKENHI-PROJECT-16590051
  • [Journal Article] Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes2020

    • Author(s)
      Hase Katsunori、Contu Viorica Raluca、Kabuta Chihana、Sakai Ryohei、Takahashi Masayuki、Kataoka Naoyuki、Hakuno Fumihiko、Takahashi Shin-Ichiro、Fujiwara Yuuki、Wada Keiji、Kabuta Tomohiro
    • Journal Title

      Autophagy

      Volume: NO Issue: 11 Pages: 1-15

    • DOI

      10.1080/15548627.2020.1712109

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-17J10610, KAKENHI-PROJECT-17K07124, KAKENHI-PROJECT-16H05146, KAKENHI-PROJECT-18F18384, KAKENHI-PROJECT-20J00363, KAKENHI-PLANNED-19H05710
  • [Journal Article] Participation of the nucleus accumbens dopaminergic system in the antidepressant-like actions of a diet rich in omega-3 polyunsaturated fatty acids2020

    • Author(s)
      Takeuchi Eri、Yamada Daisuke、Suzuki Satoshi、Saitoh Akiyoshi、Itoh Masayuki、Hayashi Takashi、Yamada Mitsuhiko、Wada Keiji、Sekiguchi Masayuki
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 3 Pages: e0230647-e0230647

    • DOI

      10.1371/journal.pone.0230647

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08086, KAKENHI-PROJECT-17K07124, KAKENHI-PROJECT-17K18402
  • [Journal Article] Pathological role of lipid interactions with α-synuclein in Parkinson’s disease.2018

    • Author(s)
      271.Suzuki, M., Wada, K., Sango, K., Nagai, Y
    • Journal Title

      Neurochem Int

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07124
  • [Journal Article] Maternal high-fat diet leads to persistent synaptic instability in mouse offspring via oxidative stress during lactation.2016

    • Author(s)
      Hatanaka Y., Wada K, Kabuta T.
    • Journal Title

      Neuroche. Int.

      Volume: 印刷中 Pages: 99-108

    • DOI

      10.1016/j.neuint.2016.03.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25290027
  • [Journal Article] Property of lysosomal storage disease associated with midbrain pathology in the CNS of LAMP-2-deficient mice.2015

    • Author(s)
      Furuta, A., Kikuchi, H., Fujita, H., Yamada, D., Kabuta, T., Blanz, J., Saftig, P., Nishino, I., Wada, K., Uchiyama, Y.
    • Journal Title

      Am. J., Pathol.

      Volume: 印刷中

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-25110739
  • [Journal Article] An RNautophagy/DNautophagy receptor, LAMP2C, possesses an arginine-rich motif that mediates RNA/DNA-binding2015

    • Author(s)
      Fujiwara Y, Hase K, Wada K, Kabuta T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 460 Issue: 2 Pages: 281-286

    • DOI

      10.1016/j.bbrc.2015.03.025

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-14J08223, KAKENHI-PROJECT-24680038, KAKENHI-PROJECT-25290027, KAKENHI-PUBLICLY-26111526
  • [Journal Article] Age-dependent sensitivity to glucocorticoids in the developing mouse basolateral nucleus of the amygdala.2014

    • Author(s)
      Koppensteiner P, Aizawa S, Yamada D, Kabuta T, Boehm S, Wada K, Sekiguchi M.
    • Journal Title

      Psychoneuroendocrinology

      Volume: 46 Pages: 64-77

    • DOI

      10.1016/j.psyneuen.2014.04.007

    • URL

      http://www.journals.elsevier.com/psychoneuroendocrinology/

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500474, KAKENHI-PUBLICLY-25110739
  • [Journal Article] Modulation of fear memory by dietary polyunsaturated fatty acids via cannabinoid receptors.2014

    • Author(s)
      Yamada D, Takeo J, Koppensteiner P, Wada K, Sekiguchi M.
    • Journal Title

      Neuropsychopharmacology

      Volume: In print Issue: 8 Pages: 1852-1860

    • DOI

      10.1038/npp.2014.32

    • URL

      http://www.nature.com/npp/index.html

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23500474, KAKENHI-PUBLICLY-25110739, KAKENHI-PROJECT-25290027
  • [Journal Article] Maternal administration of the herbal medicine Toki-shakuyaku-san promote fetal growth and placental gene expression in normal mice.2013

    • Author(s)
      Li, H., Wada, E., Wada, K.
    • Journal Title

      Am. J. Chin. Med.

      Volume: 41 Issue: 03 Pages: 515-529

    • DOI

      10.1142/s0192415x13500377

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25110739
  • [Journal Article] Ubiquitin C-terminal hydrolase L1 (UCH-L1) act as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation, independent of its hydrolase activity.2013

    • Author(s)
      Kabuta, T., Mitsui, T., Takahashi, M., Fujiwara, Y., Kabuta, C., Konya, C., Tsuchiya, Y., Hatanaka, Y., Uchida, K., Hohjoh, H., Wada, K.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Pages: 12615-12626

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25110739
  • [Journal Article] Ubiquitin C-terminal hydrolase L1 (UCH-L1) act as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation, independent of its hydrolase activity2013

    • Author(s)
      Kabuta, T., Mitsui, T., Takahashi, M., Fujiwara, Y., Kabuta, C., Konya, C., Tsuchiya, Y., Hatanaka, Y., Uchida, K., Hohjoh, H., Wada, K
    • Journal Title

      J. Biol. Chem

      Volume: 288 Issue: 18 Pages: 12615-12626

    • DOI

      10.1074/jbc.m112.435701

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650199, KAKENHI-PROJECT-24390226, KAKENHI-PROJECT-24680038, KAKENHI-PROJECT-25670428, KAKENHI-PROJECT-25871169
  • [Journal Article] Direct uptake and degradation of DNA by lysosomes2013

    • Author(s)
      Fujiwara Y, Kikuchi H, Aizawa S, Furuta A, Hatanaka Y, Konya C, Uchida K, Wada K, Kabuta T
    • Journal Title

      Autophagy

      Volume: 9 Issue: 8 Pages: 1167-71

    • DOI

      10.4161/auto.24880

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590244, KAKENHI-PROJECT-24680038, KAKENHI-PROJECT-25290027
  • [Journal Article] Sulfatide accumulation in the dystrophic terminals of gracile axonal dystrophy mice: lipid analysis using matrix-assisted laser desorption/ionization imaging mass spectrometry2013

    • Author(s)
      Onishi, K., Tasumi, Y., Wada, K., Yang, H.J., Sugiura, Y., Setou, M., Yoshikawa, H
    • Journal Title

      Med. Mol. Morphol

      Volume: (Epub ahead of print)

    • NAID

      10031203183

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650199
  • [Journal Article] Control of BACE1 and APP processing by ubiquitin carboxyl-terminal hydrolase L1 in Alzheimer's Disease Pathogenesis2012

    • Author(s)
      Zhang, M., et al
    • Journal Title

      J Neurochem

      Volume: 120 Issue: 6 Pages: 1129-1138

    • DOI

      10.1111/j.1471-4159.2011.07644.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23110527, KAKENHI-PROJECT-23650199
  • [Journal Article] Uchl1 is required for β-cell survival and function in prediabetic lipotoxic conditions2012

    • Author(s)
      Chu, K.Y., et al
    • Journal Title

      Diabetologia

      Volume: 55 Issue: 1 Pages: 128-140

    • DOI

      10.1007/s00125-011-2323-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23110527, KAKENHI-PROJECT-23650199
  • [Journal Article] Selective Neuroprotective Effects of the S18Y Polymorphic Variant of UCH-L1 in the dopaminergic system2012

    • Author(s)
      Xilouri, M., et al
    • Journal Title

      Hum Mol Genet

      Volume: 21 Issue: 4 Pages: 874-879

    • DOI

      10.1093/hmg/ddr521

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23110527, KAKENHI-PROJECT-23650199
  • [Journal Article] Parkinson's disease-associated mutations in alpha-synuclein and UCH-L1 inhibit the unconventional secretion of UCH-L12011

    • Author(s)
      Konya, C.
    • Journal Title

      Neurochem Int

      Volume: 59 Issue: 2 Pages: 251-258

    • DOI

      10.1016/j.neuint.2011.05.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22020038, KAKENHI-PROJECT-22560454, KAKENHI-PROJECT-22659172, KAKENHI-PROJECT-22790838, KAKENHI-PUBLICLY-23110528, KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-23650199
  • [Journal Article] Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drung screening.2010

    • Author(s)
      Mitsui T., Hirayama K. Aoki S., Nishikawa K., Uchida K., Matsumoto T., Kabuta T., Wada K.
    • Journal Title

      Neurochem.Int. 56

      Pages: 679-686

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Deficiency of ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) leads to vulnerability to lipid peroxidation.2010

    • Author(s)
      Nagamine S. Kabuta T., Furuta A., Yamamoto K., Takahashi A., Wada K.
    • Journal Title

      Neurochem.Int. 57

      Pages: 102-110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Skeletal muscles of Uch13 knockout mice show polyubiquitinated protein accumulation and stress responses.2010

    • Author(s)
      Setsuie R., Suzuki M., Tsuchiya Y., Wada K.
    • Journal Title

      Neurochem.Int. 56

      Pages: 911-918

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Disturbed sleep/wake rhythms and neuronal cell loss in lateral hypothalamus and retina of mice with a spontaneous deletion in the ubiquitin c-terminal hydrolase L1 gene.2010

    • Author(s)
      Pfeffer M., Plenzig S., Gispert S., Wada K., Korf H.W.von Gall, C.
    • Journal Title

      Neurobiol.Age.(Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.2009

    • Author(s)
      Yasuda T., Nihira T., Ren Y. R., Cao X.Q., Wada K., Setsuie R., Kabuta T., Wada K., Hattori N., Mizuno Y., Mochizuki H.
    • Journal Title

      J Neurochem. 108

      Pages: 932-944

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Ubiquitin dimers control the hydrolase activity of UCH-L3.2009

    • Author(s)
      Setsuie R., Sakurai M., Sakaguchi Y., Wada K.
    • Journal Title

      Neurochem.Int. 54

      Pages: 314-321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Ubiquitin C-terminal hydrolase-L3 knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle2009

    • Author(s)
      Setsuie, R., Suzuki, M., Kabuta, T., Fujita, H., Miura, S., Ichihara, N., Yamada D., Wang, Y. L., Ezaki, O., Suzuki, Y., Wada, K.
    • Journal Title

      FASEB J 23

      Pages: 4148-4157

    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Ubiquitin dimers control the hydrolase activity of UCH-L32009

    • Author(s)
      Setsuie, R., Sakurai, M., Sakaguchi, Y., Wada, K.
    • Journal Title

      Neurochem.Int. 54

      Pages: 314-321

    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Ubiquitin carboxyl-terminal hydrolase L3 promotes insulin signaling and adipogenesis2009

    • Author(s)
      Suzuki, M., Setsuie, R., Wada, K.
    • Journal Title

      Endocrinology 150

      Pages: 5230-5239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Ubiquitin C-terminal hydrolase-L3 knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle.2009

    • Author(s)
      Setsuie R., Suzuki M., Kabuta T., Fujita H., Miura S., Ichihara N., Yamada D., Wang Y.L., Ezaki O., Suzuki Y., Wada K.
    • Journal Title

      FASEB J 23

      Pages: 4148-4157

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse2009

    • Author(s)
      Goto, A., Wang, Y. L., Kabuta, T., Setsuie, R., Osaka, H., Sawa, A., Ishiura, S., Wada, K.
    • Journal Title

      Neurochem.Int. 54

      Pages: 330-338

    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Ubiquitin carboxyl-terminal hydrolase L3 promotes insulin signaling and adipogenesis.2009

    • Author(s)
      Suzuki M., Setsuie R., Wada K.
    • Journal Title

      Endocrinology 150

      Pages: 5230-5239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (god) mouse.2009

    • Author(s)
      Goto A., Wang Y. L., Kabuta T., Setsuie R., Osaka H., Sawa A., Ishiura S., Wada K.
    • Journal Title

      Neurochem.Int. 54

      Pages: 330-338

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Aberrant interaction between Parkinson's disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy.2008

    • Author(s)
      Kabuta T., Furuta A., Aoki S., Furuta K., Wada K.
    • Journal Title

      J.Biol.Chem. 283

      Pages: 23731-23738

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Reduction of memory in passive avoidance learning, exploratory behavior and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene.2008

    • Author(s)
      Sakurai M., Sekiguchi M., Zushida K., Yamada K., Nagamine S., Kabuta T., Wada K.
    • Journal Title

      Eur.J.Neurosci. 27

      Pages: 691-701

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L12008

    • Author(s)
      Kabuta, T., Setsuie, R., Mitsui, T., Kinugawa, A., Sakurai, M., Aoki, S., Uchida, K., Wada, K.
    • Journal Title

      Hum.Mol.Genet. 17

      Pages: 1482-1496

    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1.2008

    • Author(s)
      Kabuta T., Setsuie R., Mitsui T., Kinugawa A., Sakurai M., Aoki S., Uchida K., Wada K.
    • Journal Title

      Hum.Mol.Genet. 17

      Pages: 1482-1496

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Aberrant interaction between Parkinson's disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy2008

    • Author(s)
      Kabuta, T., Furuta, A., Aoki, S., Furuta, K., Wada, K.
    • Journal Title

      J.Biol.Chem. 283

      Pages: 23731-23738

    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Insights into links between familial and sporadic Parkinson's disease : Physical relationship between UCH-L1 variants and chaperone-mediated autophagy.2008

    • Author(s)
      Kabuta T. Wada K.
    • Journal Title

      Autophagy 4

      Pages: 827-829

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening.2007

    • Author(s)
      Hirayama K., Aoki S., Nishikawa K., Matsumoto T., Wada K.
    • Journal Title

      Bioorgan.Med.Chem 15

      Pages: 6810-6818

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] The functions of UCH-L1 and its relation to neurodegenerative diseases.2007

    • Author(s)
      Setsuie R., Wada K.
    • Journal Title

      Neurochem.Int. 52

      Pages: 105-111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Journal Article] Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 193M mutant.2007

    • Author(s)
      Setsuie R., Wang Y.L., Mochizuki H., Osaka H., Hayakawa H., Ichihara N., Li H., Furuta A., Sano Y., Sun Y.J., Kowan J., Kabuta T., Yoshimi K., Aoki S., Mizuno Y., Noda M., Wada K.
    • Journal Title

      Neurochem. Int. 50

      Pages: 119-129

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice.2006

    • Author(s)
      Wang Y.L., Liu W., Sun Y.J., Kwon J., Setsuie R., Osaka H., Noda M., Aoki S., Yoshikawa Y., Wada K.
    • Journal Title

      Mol. Reprod. Dev. 73

      Pages: 40-49

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Characterization of multimetric variants of ubiquitin carboxyl-terminal hydrolase Ll in water by small-angle neutron scattering.2006

    • Author(s)
      Naito S., Mochizuki H., Yasuda T., Mizuno Y., Furusaka M., Ikeda S., Adachi T., Shimizu HM., Suzuki J., Fujiwara S., Okada T., Nishikawa K., Aoki S., Wada K.
    • Journal Title

      Biochem Biophys Res Commun. 339

      Pages: 717-725

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Anti-inflammatory effects of kinins via microglia in the central nervous system.2006

    • Author(s)
      Noda M., Kettenmann H., Wada K.
    • Journal Title

      Biological Chemistry 387

      Pages: 167-171

    • Data Source
      KAKENHI-PROJECT-16590051
  • [Journal Article] Kinin-induced microglial migration and anti-inflammatory effects in the central nervous system.2006

    • Author(s)
      Noda, M., Ifuku, M., Farber, K., Kettenmann, H., Wada, K.
    • Journal Title

      Journal of Neurochemistry 96(1)

      Pages: 42-42

    • Data Source
      KAKENHI-PROJECT-16590051
  • [Journal Article] The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis.2006

    • Author(s)
      Kwon J., Sekiguchi S., Wang Y.L., Setsuie R., Yoshikawa Y., Wada K.
    • Journal Title

      Exp. Anim. 55(1)

      Pages: 35-43

    • NAID

      10016942132

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Photoreceptor cell apoptosis in the retinal degeneration of Uch13 deficient mice.2006

    • Author(s)
      Sano Y., Furuta A., Setsuie R., Kikuchi H., Wang Y.L., Sakurai M., Kwon J., Noda M., Wada K.
    • Journal Title

      Am. J. Pathol. 169

      Pages: 132-141

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Parkin potentiates ATP-induced currents due to activation of P2X receptors in PC12 cells.2006

    • Author(s)
      Sato A., Arimura Y., Manago Y., Nishikawa K., Aoki K., Wada E., Suzuki Y., Osaka H., Setsuie R., Sakurai M., Amano T., Aoki S., Wada K., Noda M.
    • Journal Title

      J. Cell. Physiol. 209

      Pages: 172-182

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Localization of ubiquitin C-terminal hydrolase LI in mouse ova and its function in the plasma membrane to block polyspermy.2006

    • Author(s)
      Sekiguchi S., Kwon J., Yoshida E., Hamasaki H., Ichinose S., Hideshima M., Kuraoka M., Takahashi A., Ishii Y., Kyuwa S., Wada K., Yoshikawa Y.
    • Journal Title

      Am. J. Pathol. 169

      Pages: 1722-1729

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Ubiquitin C-terminal hydrolase Ll regulates the morphology of neural progenitor cells and modulates their differentiation.2006

    • Author(s)
      Sakurai M., Ayukawa K., Setsuie R., Nishikawa K., Hara Y., Ohashi H., Nishimoto M., Abe T., Kudo Y., Sekiguch M., Sato Y, Aoki S., Noda M., Wada K.
    • Journal Title

      J. Cell Sci. 119(Pt1)

      Pages: 162-171

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Degradation of amyotrophic lateral sclerosis-linked mutant SOD1 proteins by macroautophagy and the proteasome.2006

    • Author(s)
      Kabuta T., Suzuki Y., Wada K.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 30524-30533

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Potentiation of ATP-induced currents due to the activation of P2X receptors by ubiquitin carboxy-terminal hydrolase Ll.2005

    • Author(s)
      Manago Y., Kanahori Y., Shimada A., Sato A., Amano T., Sato Y., Setsuie R., Sakurai M., Aoki S., Wang Y.L., Osaka H., Wada K., Noda M.
    • Journal Title

      J. Neurochem. 92

      Pages: 1061-1072

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Anti-inflammatory effects of kinins via microglia in the central nervous system.2005

    • Author(s)
      Noda M, kettenmann H, Wada K.
    • Journal Title

      Biol. Chem 387

      Pages: 167-171

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590051
  • [Journal Article] The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.2005

    • Author(s)
      Mi W., Beirowski B., Gillingwater T.H., Adalbert R., Wagner D., Grumme D., Osaka H., Conforti L., Arnhold S., Addicks K., Wada K., Ribchester R.R., Coleman M.P.
    • Journal Title

      Brain. 128

      Pages: 405-416

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Anti-inflammatory effects of kinins via microglia in the central nervous system.2005

    • Author(s)
      Noda M., Kettenmann H., Wada K.
    • Journal Title

      Biol.Chem. 387

      Pages: 167-171

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590051
  • [Journal Article] Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.2005

    • Author(s)
      Wang Y.L., Liu W., Wada E., Murata M., Wada K., Kanazawa I.
    • Journal Title

      Neurosci. Res. 53

      Pages: 241-249

    • NAID

      10017130730

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Does Proteosome Inhibition Decrease or Accelerate Toxin-Induced Dopaminergic2005

    • Author(s)
      Setsuie R., Kabuta T., Wada K.
    • Journal Title

      J Pharmacol Sci. 97

      Pages: 457-460

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Potentiation of ATP-induced currents due to the activation of P2X receptors by ubiquitin carboxy-terminal hydrolase L1.2005

    • Author(s)
      Manago Y, Kanahori Y, Shimada A, Sato A, Amano T, Sano-Sato Y, Setsuie R, Sakurai M, Aoki S, WangY, Osaka H, Wada K, Noda M
    • Journal Title

      J.Neurochemistry 92

      Pages: 1061-1072

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590051
  • [Journal Article] Ubiquitin C-terminal hydrolase Ll is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis.2005

    • Author(s)
      Kwon J., Mochida K., Wang Y.L., Sekiguchi S., Sankai T., Aoki S., Ogura A., Yoshikawa Y., Wada K.
    • Journal Title

      Biol. Reprod. 73

      Pages: 29-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Multiple signal transduction pathways mediated by 5-HT receptors.2004

    • Author(s)
      Noda M, Higashida H, Aoki S, Wada K.
    • Journal Title

      Molecular Neurobiology 29

      Pages: 31-39

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590051
  • [Journal Article] Heterogeneity and potentiation of AMPA-type of glutamate receptors in rat cultured microglia.2004

    • Author(s)
      Hagino Y, Kariura Y, Manago Y, Amano T, Wang B, Sekiguchi M, Nishikawa K, Aoki S, Wada K, Noda M
    • Journal Title

      GLIA 47

      Pages: 68-77

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590051
  • [Journal Article] Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testes.2004

    • Author(s)
      Kwon J., Wang Y.L., Setsuie R., Sekiguchi S., Sato Y., Sakurai M., Noda M., Aoki S., Yoshikawa Y., Wada K.
    • Journal Title

      Am. J. Pathol. 165

      Pages: 1367-1374

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Developmental regulation of ubiquitin C-terminal hydrolase isozyme expression during spermatogenesis in mice.2004

    • Author(s)
      Kwon J., Wang Y.L., Setsuie R., Sekiguchi S., Sakurai M., Sato Y., Lee W.W., Ishii Y., Kyuwa S., Noda M., Wada K., Yoshikawa Y.
    • Journal Title

      Biol. Reprod. 71

      Pages: 515-521

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Accumulation of beta-and gamma-synucleins in the ubiquitin C-terminal hydrolase L1 deficient gad mouse.2004

    • Author(s)
      Wang Y.L., Takeda A., Osaka H., Hara Y., Furuta A., Setsuie R., Sun Y.J., Kwon J., Sato Y., Sakurai M., Noda M., Yoshikawa Y., Wada K.
    • Journal Title

      Brain Res 1019

      Pages: 1-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Microarray expression analysis of gad mice implicates involvement of Parkinson' s disease associated UCH-L1 in multiple metabolic pathways.2004

    • Author(s)
      Bonin M., Poths S., Osaka H., Wang Y.L., Wada K., Riess O.
    • Journal Title

      Mol Brain Res. 126

      Pages: 88-97

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300126
  • [Journal Article] Kinin receptors in cultured rat microglia.2004

    • Author(s)
      Noda M., Kariura Y., Amano T., Manago Y., Nishikawa K, Aoki S., Wada K.
    • Journal Title

      Neurochemistry International 45

      Pages: 437-442

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590051
  • [Journal Article] Multiple signal transduction pathways mediated by 5-HT receptors.2004

    • Author(s)
      Noda M, Higashida H, Aoki S, Wada K
    • Journal Title

      Molecular Neurobiology 29

      Pages: 31-39

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590051
  • [Journal Article] TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress

    • Author(s)
      Shinji Higashi, Tomohiro Kabuta, Yoshitaka Nagai, Yukihiro Tsuchiya, Haruhiko Akiyama, Keiji Wada
    • Journal Title

      J Neurochem

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791008
  • [Presentation] Therapeutic Strategies for Brain Disorders as Systemic Disease2015

    • Author(s)
      和田圭司
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2015-09-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-25290027
  • [Presentation] 研究の醍醐味:わくわく、どきどきの世界2014

    • Author(s)
      和田圭司
    • Organizer
      愛媛大学第12回医科学研究発表会
    • Place of Presentation
      松山、愛媛大学医学部講堂
    • Year and Date
      2014-09-18
    • Data Source
      KAKENHI-PROJECT-25290027
  • [Presentation] High-nutrient diet aggravates protein misfolding-related neurodegeneration in Drosophila.2014

    • Author(s)
      Suzuki M, Fujikake N, Wada K, Nagai Y
    • Organizer
      New Frontier of Molecular Neuropathology 2014
    • Place of Presentation
      東京医科歯科大学
    • Data Source
      KAKENHI-PROJECT-25290027
  • [Presentation] 脳の仕組みについて2014

    • Author(s)
      和田圭司
    • Organizer
      世界脳週間イベント
    • Place of Presentation
      小平、国立精神・神経医療研究センターセミナールーム
    • Year and Date
      2014-07-19
    • Data Source
      KAKENHI-PROJECT-25290027
  • [Presentation] 食習慣と脳機能発達2013

    • Author(s)
      和田圭司
    • Organizer
      第90回日本生理学会大会シンポジウム53
    • Place of Presentation
      タワーホール船堀、東京
    • Year and Date
      2013-03-29
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-23110527
  • [Presentation] 脳におけるRNAを標的とした新規オートファジー経路2013

    • Author(s)
      藤原悠紀、和田圭司、株田智弘
    • Organizer
      Neuro2013
    • Place of Presentation
      京都国際会議場
    • Invited
    • Data Source
      KAKENHI-PROJECT-25290027
  • [Presentation] 恐怖記憶は脳内のオメガ3/オメガ6多価不飽和脂肪酸のバランスにより修飾される2013

    • Author(s)
      山田大輔, 竹尾仁良, 和田圭司, 関口正幸
    • Organizer
      Neuro2013
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PROJECT-25290027
  • [Presentation] 母体肥満が子どものシナプス発達に及ぼす影響の解析2013

    • Author(s)
      畑中悠佑、和田圭司、株田智弘
    • Organizer
      Neuro2013
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PUBLICLY-25110739
  • [Presentation] 恐怖記憶は脳内のオメガ3/オメガ6多価不飽和脂肪酸のバランスにより修飾される2013

    • Author(s)
      山田大輔, 竹尾仁良, 和田圭司, 関口正幸
    • Organizer
      Neuro2013
    • Place of Presentation
      京都国際会議場
    • Data Source
      KAKENHI-PUBLICLY-25110739
  • [Presentation] Direct Uptake and Degradation of RNA by Lysosomes.2013

    • Author(s)
      Fujiwara Y, Wada K, Kabuta T
    • Organizer
      Autophagy:molecular mechanism, physiology & pathology
    • Place of Presentation
      Hurtigruten MS Trollfjord, Norway
    • Data Source
      KAKENHI-PROJECT-25290027
  • [Presentation] 神経変性疾患の予防をめざして:脳-臓器間ネットワークからの解析2012

    • Author(s)
      和田圭司
    • Organizer
      大坂大学蛋白質研究所セミナー
    • Place of Presentation
      吹田市、大阪、大坂大学蛋白質研究所講堂(招待講演)
    • Year and Date
      2012-03-01
    • Data Source
      KAKENHI-PUBLICLY-23110527
  • [Presentation] 神経変性疾患の予防をめざして:脳―臓器間ネットワークからの解析2012

    • Author(s)
      和田圭司
    • Organizer
      大阪大学蛋白質研究所セミナー神経疾患の克服に向けて
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23650199
  • [Presentation] 神経変性疾患の予防をめざして:脳―臓器間ネットワークからの解析2012

    • Author(s)
      和田圭司
    • Organizer
      大阪大学蛋白質研究所セミナー(招待講演)
    • Place of Presentation
      大阪大学蛋白質研究所(大阪)
    • Data Source
      KAKENHI-PROJECT-23650199
  • [Presentation] gadmouse 延髄薄束核における神経軸索内蓄積物の検討2011

    • Author(s)
      大西沙代子, 芳川浩男, 辰己吉記, 杉 浦悠毅, 梁腎正, 和田圭司, 瀬藤光 利
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23650199
  • [Presentation] マウス母体の高脂肪食摂取が仔の脳機能に及ぼす影響について2011

    • Author(s)
      和田圭司
    • Organizer
      第27回日本糖尿病・妊娠学会年次学術集会
    • Place of Presentation
      神戸、神戸商工会議所会館神商ホール(招待講演)
    • Year and Date
      2011-11-12
    • Data Source
      KAKENHI-PUBLICLY-23110527
  • [Presentation] 中枢神経系‐神経症状のようなものを見つけたときにどうするか:論文化への道標‐2011

    • Author(s)
      和田圭司
    • Organizer
      第58回日本実験動物学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23650199
  • [Presentation] 神経変性疾患を防ぐ:治療から予防へ2011

    • Author(s)
      和田圭司
    • Organizer
      第13回応用薬理シンポジウム
    • Place of Presentation
      江戸川区、東京、船橋市民文化創造館船橋きららホール(招待講演)
    • Year and Date
      2011-09-03
    • Data Source
      KAKENHI-PUBLICLY-23110527
  • [Presentation] 中枢神経系-神経症状のようなものを見つけたときにどうするか:論文化への道標-2011

    • Author(s)
      和田圭司
    • Organizer
      第58回日本実験動物学会総会(招待講演)
    • Place of Presentation
      タワーホール船堀(東京)
    • Data Source
      KAKENHI-PROJECT-23650199
  • [Presentation] 家族性パーキンソン病変異によるUCH-L1の分泌減少2010

    • Author(s)
      紺谷千穂,藤原悠紀,永井義隆,内田健康,和田圭司,株田智弘
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] ライソゾーム蓄積病モデルとしてのLAMP-2ノックアウトマウス脳2009

    • Author(s)
      古田晶子、菊地寿枝、和田圭司
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-16
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] LAMP-2ノックアウトマウスにおけるGAPDH蓄積は遅発性神経細胞死を助長する2009

    • Author(s)
      藤本陽平、古田晶子、和田圭司
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-16
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] 脱ユビキチン化酵素とaxonal dystrophy : gadマウス研究からの教訓2009

    • Author(s)
      和田圭司
    • Organizer
      第41回日本臨床分子形態学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-09-04
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] 脱ユビキチン化酵素と axonal dystrophy : gad マウス研究からの教訓2009

    • Author(s)
      和田圭司
    • Organizer
      第41回日本臨床分子形態学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-09-04
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] 脱ユビキチン化酵素と axonal dystrophy:gadマウス研究からの教訓2009

    • Author(s)
      和田圭司
    • Organizer
      第41回日本臨床分子形態学会総会・学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2009-09-04
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] Identification of novel inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening, 3DSig 2008.2008

    • Author(s)
      Hirayama K, Aoki S, Nishikawa K, Matsumoto T, Wada K
    • Organizer
      Structural Bioinformatics and Computational Biophysics(pp.40-42)
    • Place of Presentation
      Canada
    • Year and Date
      2008-07-18
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] The de-ubiquitinating enzyme, UCH-L1, and lipidporoxidation.2008

    • Author(s)
      Nagamine S, Kabuta T, Yamamoto K, Takahashi A, Wada K
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] Identification of novel inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening"2008

    • Author(s)
      Hirayama K, Aoki S, Nishikawa K, Matsumoto T, Wada K
    • Organizer
      The 2nd Taiwan-Japan Young Researchers Conference on Computational and Systems Biology(p.45)
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-11-04
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] カルボニル化UCH-L1とパーキンソン病関連変異型I93M UCH-L1に共通した異常な分子的性質2008

    • Author(s)
      株田智弘, 節家理恵子, 三井丈史, 衣川亜衣子, 櫻井省花子, 青木俊介, 内田健康, 和田圭司
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] Decreased secretion of UCH-L1 and SOD1 by the mutations associated with neurodegenerative diseases.2008

    • Author(s)
      Konya C, Kabuta T, Kinugawa A, Wada K
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] Identification of novel inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening"2008

    • Author(s)
      Hirayama K, Aoki S, Nishikawa K, Matsumoto T, Wada K
    • Organizer
      16th International Conference on Intelligent Systems for Molecular Biology (ISMB)
    • Place of Presentation
      Canada
    • Year and Date
      2008-07-21
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] Regulation of energy homeostasis by UCH-LI and UCH-L32008

    • Author(s)
      Suzuki M, Setsuie R, Wada K
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] カルボニル化UCH-L1とパーキンソン病関連変異型193M UCH-L1に共通した異常な分子的性質2008

    • Author(s)
      株田智弘,節家理恵子,三井丈史,衣川亜衣子,櫻井省花子,青木俊介,内田健康,和田圭司
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] UCH-L1による細胞増殖促進2008

    • Author(s)
      三井丈史,株田智弘,株田千華,内田健康,和田圭司
    • Organizer
      BMB2008
    • Place of Presentation
      兵庫
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] ユビキチンC末端加水分解酵素の機能2008

    • Author(s)
      節家理恵子,古田品子,和田圭司
    • Organizer
      神経組織の成長・再生・移植研究会第23学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2008-05-17
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] Aberrant interaction between familial Parkinson's disease-associated mutant UCH-Ll and the lysosomal receptor for chaperone-mediated autophagy.2008

    • Author(s)
      Kabuta T, Furuta A, Aoki S, Furuta K, Wada K
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] The de-ubiquitinating enzyme, UCH-L1, and lipid poroxidation2008

    • Author(s)
      Nagamine S, Kabuta T, Yamamoto K, Takahashi A, Wada K
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] アストロサイトに発現するGPCRの機能解析2007

    • Author(s)
      和田 圭司, 他
    • Organizer
      Neuro 2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-12
    • Data Source
      KAKENHI-PROJECT-15082214
  • [Presentation] UCH-Lファミリー分子群を標的としたin silicoドッキング・シュミレーションによる新規作用薬剤の同定2007

    • Author(s)
      青木俊介,平山和徳,和田圭司
    • Organizer
      第15回日本精神・行動遺伝医学会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-17
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] Effect of UCH-L1 on the alpha-synuclein-induced dopaminergic neurodegeneration in vivo.2007

    • Author(s)
      Yasuda T, Wada K, Mizuno Y, Mochizuki H
    • Organizer
      Society for Neuroscience 37^<th> Annual Meeting.
    • Place of Presentation
      San Diego, California, U.S.A.
    • Year and Date
      2007-11-04
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] マウス神経系前駆細胞におけるGPCRの機能解析2007

    • Author(s)
      和田 圭司, 他
    • Organizer
      神経組織の成長・再生・移植研究会第22回学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2007-05-26
    • Data Source
      KAKENHI-PROJECT-15082214
  • [Presentation] 変異SOD1タンパク質のマクロオートファージによる分解2007

    • Author(s)
      和田 圭司, 他
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-16
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] Small-angle neutron scattering (SANS) and dynamic light scattering (DLS) analyses of the initial aggregation process of tau by oxidative stress.2007

    • Author(s)
      Naito S, Ikeda S, Shimizu H, Mochizuki H, Yasuda T, Mizuno Y, Furusaka M, Fujiwara S, Suzuki J, Wada K
    • Organizer
      Neuro2007.
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-09-11
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] virtual screeningによるUCH-Lファミリー活性調節剤探索研究2007

    • Author(s)
      平山和徳,青木俊介,西川香里,松本隆,和田圭司
    • Organizer
      内閣府第2回ナノバイオテクノロジー連携群成果報告会
    • Place of Presentation
      京都
    • Year and Date
      2007-12-05
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] 脱ユビキチン化酵素と神経変性.2007

    • Author(s)
      和田 圭司, 他
    • Organizer
      第12回パーキンソン病フォーラム-基礎と臨床
    • Place of Presentation
      京都
    • Year and Date
      2007-09-29
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] Virtual screeningによるUCH-L3の新規阻害剤同定2007

    • Author(s)
      平山和徳,青木俊介,西川香里,松本隆,和田圭司
    • Organizer
      第35回構造活性相関シンポジゥム
    • Place of Presentation
      京都
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] Identification of novel UCH-L1-potentiating compounds by in silico drug screening.2007

    • Author(s)
      Hirayama K, Aoki S, Nishikawa K, Matsumoto T, Wada K
    • Organizer
      Neuro 2007.
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-09-10
    • Data Source
      KAKENHI-PROJECT-19200032
  • [Presentation] 精神疾患の病院に関与する物質・因子の解析:テストステロンおよびリソソーム分解との関連性について

    • Author(s)
      株田智弘、畑中悠佑、和田圭司
    • Organizer
      第57回日本神化学会大会
    • Place of Presentation
      奈良、奈良県新公会堂
    • Year and Date
      2014-09-29 – 2014-10-01
    • Data Source
      KAKENHI-PUBLICLY-25110739
  • 1.  NODA Mami (80127985)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 10 results
  • 2.  SEKIGUCHI Masayuki (80260339)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 3.  FURUSAKA Michihiro (60156966)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  KABUTA Tomohiro (70535765)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 5.  NISHIKAWA Toru (00198441)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  田中 光一 (80171750)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  MORITA Takuma
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  SUGIYAMA Masaaki (10253395)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  MOCHIDUKI Hideki (90230044)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  FUJITA Fumiyuki (10002312)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  HOMMA Akira (80374594)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HIGASHI Shinji (30365647)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  AKIYAMA Haruhiko (20231839)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 14.  NAGAI Yoshitaka (60335354)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  KOHSAKA Shinichi (50112686)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  TAKAHASHI Katunobu (40183850)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  内藤 幸雄 (20312233)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  越谷 和雄
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  伯野 史彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  高橋 伸一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  竹内 絵理
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  古田 晶子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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