OKAMOTO Susumu 岡本晋

… Alternative Names

岡本晋オカモトススム

Less

Researcher Number	70255446
Other IDs
Affiliation (based on the past Project Information) *help	2006 – 2010: 慶應義塾大学, 医学部, 講師 2009: 医学部, 講師 2004 – 2005: 慶應義塾大学, 医学部, 助手 1996 – 1998: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Immunology
Keywords	Principal Investigator クローン病 / SAP / Th1 / sugar chain / lectin / dendritic cells / Crohn / 糖鎖抗原 / レクチン / 樹状細胞 … More / T cell / IBD / T細胞 / 炎症性腸疾患 / マクロファージ / オートファジー / 移植 / SCID / NOD / HCV / 抗CD4抗体 / CD4アナログ / 動物モデル … More Except Principal Investigator 細胞内寄生菌 / 自然免疫 / オートファジー / クローン病 / マクロファージ / 腸内細菌 / 粘膜免疫 / 炎症性腸疾患 Less

Elucidation of intestinal mucosal immune system through the intracellular processing mechanisms of bacteria and its application for novel therapy of inflammatory bowel disease
- Principal Investigator
  
  INOUE Nagamu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Immunology
- Research Institution
  Keio University
Defective autophagy system against bacteria in Crohn's macrophagesPrincipal Investigator
- Principal Investigator
  
  SUSUMU Okamoto
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Defective response to bacteria through lectin-type receptors in dendritic cells from Crohn diseasesPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Susumu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Exploitation of a novel therapy for inflammatory bowel diseases by modulating SAP, a T cell specific adaptor moleculePrincipal Investigator
- Principal Investigator
  
  OKAMOTO Susumu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
ヒト肝組織、免疫細胞を再構築したNOD/SCIDを用いたC型肝炎肝癌発症機序Principal Investigator
- Principal Investigator
  
  岡本晋
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
CD4アナログを用いた炎症性腸疾患に対する新たな免疫統御療法の開発Principal Investigator
- Principal Investigator
  
  岡本晋
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University

All 2010 2009 2008

All Journal Article Presentation

[Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.2010
- Author(s)
  Mikami Y, Kanai T, Sujino T, Ono Y, Hayashi A, Okazawa A, Kamada N, Matsuoka K, Hisamatsu T, Okamoto S, Takaishi H, Inoue N, Ogata H, Hibi T
- Journal Title
  
  Eur J Immunol 40(9)
  
  Pages: 2409-2422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200080
[Journal Article] Novel endoscopic activity index is useful for choosing treatment in severe active ulcerative colitis patients.2010
- Author(s)
  Naganuma M, Ichikawa H, Inoue N, Kobayashi T, Okamoto S, Hisamatsu T, Kanai T, Ogata H, Iwao Y, Hibi T
- Journal Title
  
  J Gastroenterol. 45(9)
  
  Pages: 936-43
- NAID
  10027698991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590750
[Journal Article] Rapid endoscopic improvement is important for 1-year avoidance of colectomy but not for the long-term prognosis in cyclosporine A treatment for ulcerative colitis.2010
- Author(s)
  Kobayashi T, Naganuma M, Okamoto S, Hisamatsu T, Inoue N, Ichikawa H, Takayama T, Saito R, Sujino T, Ogata H, Iwao Y, Hibi T
- Journal Title
  
  J Gastroenterol. 45(11)
  
  Pages: 1129-37
- NAID
  10027699761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590750
[Journal Article] Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.2010
- Author(s)
  Takayama T, Kamada N, Chinen H, Okamoto S, Kitazume MT, Chang J, Matuzaki Y, Suzuki S, Sugita A, Koganei K, Hisamatsu T, Kanai T, Hibi T
- Journal Title
  
  Gastroenterology. 139(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590750
[Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.2010
- Author(s)
  Mikami Y, Kanai T, Sujino T, Ono Y, Hayashi A, Okazawa A, Kamada N, Matsuoka K, Hisamatsu T, Okamoto S, Takaishi H, Inoue N, Ogata H, Hibi T
- Journal Title
  
  Eur J Immunol. 40(9)
  
  Pages: 2409-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590750
[Journal Article] Non-pathogenic Escherichia coli strain Nissle 1917 inhibits signal transduction in intestinal epithelial cells.2008
- Author(s)
  Kamada N, Maeda K, Inoue N, Hisamatsu T, Okamoto S, Hong KS, Yamada T, Watanabe N, Tsuchimoto K, Ogata H, Hibi T
- Journal Title
  
  Infect Immun 76(1)
  
  Pages: 214-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200080
[Journal Article] IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease2008
- Author(s)
  Kobayashi T, Okamoto S, et.al.
- Journal Title
  
  Gut 57
  
  Pages: 1682-1689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] 腸管マクロファージからみたクローン病のサイトカインネットワーク異常2010
- Author(s)
  久松理一、鎌田信彦、高山哲朗、齋藤理子、米野和明、松岡克善、岡本晋、井上詠、緒方晴彦、金井隆典、日比紀文
- Organizer
  第47回日本消化器免疫学会総会、シンポジウム
- Place of Presentation
  滋賀
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] IL-10KOマウスにおけるマクロファージからのIL-12過剰産生機序の解明2009
- Author(s)
  成瀬浩史、久松理一、鎌田信彦、岡本晋、井上詠、金井隆典、日比紀文
- Organizer
  第46回日本消化器免疫学会、一般演題
- Place of Presentation
  愛媛
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] クローン病におけるCD14+腸管マクロファージの抗原提示能について2009
- Author(s)
  久松理一、鎌田信彦、本田治樹、北爪美奈、井上詠、岡本晋、金井隆典、日比紀文
- Organizer
  第46回日本消化器免疫学会、シンポジウム
- Place of Presentation
  愛媛
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] 胆汁酸はTGR5受容体を介してIL-12低産生型樹状細胞に分化誘導する/Bile acids generate IL-12 hypoproducingDCs via Tgr5 signaling pathway2009
- Author(s)
  Saito R, Hisamatsu T, Takayama T, Kamada N, Ando S, Inoue N, Okamoto S, Kanai T, Hibi T
- Organizer
  第39回日本免疫学会総会・学術集会、ワークショップ
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] クローン病における腸管マクロファージの腸内細菌認識異常 -IL-23を中心とした慢性炎症サイクル-2008
- Author(s)
  久松理一、鎌田信彦、小林拓、岡本晋、井上詠、緒方晴彦、金井隆典、日比紀文
- Organizer
  第45回日本消化器免疫学会、シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-07-04
- Data Source
  KAKENHI-PROJECT-20200080
[Presentation] MCP-1依存性腸管マクロファージサブセットの腸管免疫恒常性における役割2008
- Author(s)
  高田康裕、久松理一、鎌田信彦、斎藤理子、高山哲朗、市川仁志、小林拓、知念寛、井上詠、岡本晋、日比紀文
- Organizer
  第45回日本消化器免疫学会、一般演題
- Place of Presentation
  京都
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PROJECT-20200080

1. HIBI Toshifumi (50129623)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. INOUE Nagamu (00232546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. HISAMATSU Tadakazu (60255437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. WATANABE Mamoru (10175127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. MORIMOTO Chikao (30119028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OKAMOTO Susumu 岡本 晋

岡本 晋 オカモト ススム

Research Projects

Research Products

Co-Researchers

Elucidation of intestinal mucosal immune system through the intracellular processing mechanisms of bacteria and its application for novel therapy of inflammatory bowel disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Defective autophagy system against bacteria in Crohn's macrophagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Defective response to bacteria through lectin-type receptors in dendritic cells from Crohn diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploitation of a novel therapy for inflammatory bowel diseases by modulating SAP, a T cell specific adaptor moleculePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト肝組織、免疫細胞を再構築したNOD/SCIDを用いたC型肝炎肝癌発症機序Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

CD4アナログを用いた炎症性腸疾患に対する新たな免疫統御療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.2010

Author(s)

Journal Title

Data Source

[Journal Article] Novel endoscopic activity index is useful for choosing treatment in severe active ulcerative colitis patients.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Rapid endoscopic improvement is important for 1-year avoidance of colectomy but not for the long-term prognosis in cyclosporine A treatment for ulcerative colitis.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.2010

Author(s)

Journal Title

Data Source

[Journal Article] Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis.2010

Author(s)

Journal Title

Data Source

[Journal Article] Non-pathogenic Escherichia coli strain Nissle 1917 inhibits signal transduction in intestinal epithelial cells.2008

Author(s)

Journal Title

Data Source

[Journal Article] IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease2008

Author(s)

Journal Title

Data Source

[Presentation] 腸管マクロファージからみたクローン病のサイトカインネットワーク異常2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] IL-10KOマウスにおけるマクロファージからのIL-12過剰産生機序の解明2009

Author(s)

Organizer

OKAMOTO Susumu 岡本晋

岡本晋オカモトススム