Hosoya Kenichi 細谷健一

… Alternative Names

HOSOYA Ken-ichi 細谷健一

細谷建一ホソヤケンイチ

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Researcher Number	70301033
Other IDs
External Links
Affiliation (Current)	2025: 富山大学, 学術研究部薬学・和漢系, 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 富山大学, 学術研究部薬学・和漢系, 教授 2012 – 2018: 富山大学, 大学院医学薬学研究部(薬学), 教授 2008 – 2011: University of Toyama, 大学院・医学薬学研究部(薬学), 教授 2007: University of Toyama, Department of Pharmaceutics, Professor 2006: 富山大学, 大学院医学薬学研究部, 教授 … More 2000 – 2004: 富山医科薬科大学, 薬学部, 教授 1999: Graduate School of Pharmaceutical Sciences, Tohoku University, Assistant Professor, 大学院・薬学研究科, 助手 1998: 東北大学, 教務職員 1998: 東北大学, 薬学部, 教務職員 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / 応用薬理学・医療系薬学 / 医薬分子機能学 Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / 応用薬理学・医療系薬学 / Medical pharmacy / 医薬分子機能学 / Eating habits, studies on eating habits
Keywords	Principal Investigator 血液網膜関門 / vitamin C / GLUT1 / 内側血液網膜関門 / 網膜毛細血管内皮細胞 / 条件的不死化細胞株 / 酸化的ストレス / 血液脳関門 / プロスタグランジン / LAT1 … More / 血管新生 / モノカルボン酸トランスポーター / MCT / OAT / oatp / co-culture / conditionally immortalized cell line / blood-retinal barrier / TR-iBRB細胞 / system xc^- / 共培養 / カチオン性薬物 / 薬学 / PGE2 / 血液脳脊髄液関門 / 有機アニオン輸送担体 / トランスポーター / 排出輸送 / 網膜色素上皮細胞 / 網膜ペリサイト株 / MCT1 / 眼 / クレアチン / プロドラッグ / コネキシン / Cx43 / ヘミチャネル / 外側血液網膜関門 / 網膜疾患 / スクリーニング / カチオン性薬物輸送機構 / ドラッグリポジショニング / 薬物輸送担体 / カチオン性薬物輸送 / p-Aminohippuric acid / Estradiol 17-β glucuronide / Efflux transport / Microdialysis / Blood-retinal barrier / Oatp / dehydroepiandrosterone sulfate / estradiol 17-β glucuronide / p-aminohiuric acid / 免疫染色 / ρ-aminohippuric acid / estradiol17-βglucuronide / マイクロダイアリシス法 / transport mechanism / TR-iBRB cells / diabetes / antioxidant / oxidative stress / 担体輸送 / 輸送機構 / 糖尿病 / 抗酸化物質 / oxidative stress condition / system xc / cell growth regulating factor / retinal pericyte cell line / retinal endothelial cell line / inner blood-retinal barrier / system x_c^- / 液性因子 / TGFβ1 / 増殖抑制因子 / 網膜毛細血管内皮細胞株 / Muller cell / system xc- / intercellular adhesion molecule-1 / α-smooth muscle actin / ペリサイト株 / 培養細胞株 / GLAST / Muller細胞株 / 浸透圧 / TAUT / アミノ酸輸送 / TR-MUL細胞 / Muller細胞 / 輸送活性・物性相関 / 有機カチオン輸送担体 / インフラックス / TR-iBRB2 / 有機カチオン性薬物 / ベラパミル / Influx / P-糖タンパク質 / 有機カチオン輸送体 / 神経伝達物質 / リポ多糖 / プロスタグランジン合成酵素 / 脳内炎症 / 脳関門 / 脳脊髄液 / 脳・神経 / クリアランス / 担体介在型輸送 / ヒト網膜色素上皮細胞 / LRP-1 / ARPE-19細胞 / RNA干渉法 / アミロイドβ / Dual-luciferase assay / 糖尿病網膜症 / プロモーター解析 / アミノ酸トランスポター / MAPK / PKC / リコンビナントタンパク / 細胞増殖抑制因子 / 網膜ペリサイト / グルコース輸送 / GLUT-1 / 不死化細胞クローン / T-抗原 / 網膜 / 温度感受性SV40T抗原遺伝子導入トランスジェニックラット / MCT2 / モノカルボン酸輸送 / 乳酸輸送 / P-糖蛋白質 … More Except Principal Investigator 血液脳関門 / トランスポーター / 血液網膜関門 / conditionally immortalized cell line / blood-brain barrier / 条件的不死化細胞 / 脳毛細血管内皮細胞 / P-糖蛋白 / グルタミン酸 / 中枢解毒 / 輸送担体 / 細胞膜輸送 / brain capillary endothelial cell / 不死化細胞クローン / 脳 / 血液脳脊髄液関門 / シスチン / ステロイド / 排出輸送系 / トランスサイトーシス / 受容体 / 細胞膜透過ペプチド / 栄養物輸送 / 栄養物 / 薬物輸送 / 抗ウイルス薬 / HIV / タウリン / セルトリ細胞 / 膜輸送 / 血液精巣関門 / イメージング / P-糖タンパク質 / 網膜毛細血管 / エフラックス輸送 / インフラックス輸送 / 血液組織関門 / 神経保護薬 / カチオン性薬物 / 脳毛細血管 / BBB / L-グルタミン酸 / てんかん / 有機アニオン輸送担体 / PGE2 / プロスタグランジン / membrane transporter / drug screening / brain capillary endothelial cells / culture cell / gene expression / plasma membrane / 新薬スクリーニング / 培養細胞 / 遺伝子発現系 / central nervous system detoxification / cDNA cloning / organic anion transporter / neurotransmitter / membrane transport / 遺伝子クローニング / 神経伝達物質 / P-glycoprotein / p53 protein / tight junction protein / glucose transporter / temperature sensitive SV40T antigen gene / グルコース輸送 / GLUT-1 / 温度感受性SV40T抗原遺伝子導入トランスジェニック動物 / グルコース / トランスジェニック動物 / p53 / タイトジャンクション / グルコース輸送担体 / 温度感受性SV40T抗原遺伝子 / organic anion transport system / System Xc / estorone sulfate / acidic amino acid / efflux transport / cerebral detoxification / blood-cerebrospinal fluid barrier / blood-brain-barrier / 分子多様性 / oatp2 / D-アスパラギン酸 / L-アスパラギン酸 / 有機アニオン輸送系 / システムX_c / エストロン硫酸抱合体 / 酸性アミノ酸 / プロテオミクス / 光反応性プローブ / ドコサヘキサエン酸 / 新生児 / 必須脂肪酸 / 食と栄養 / アミノ酸輸送 / System-A / T-抗原 / トランスジェニックラット / 脈絡叢上皮細胞 / 有機アニオン Less

脳クレアチン供給を実現するモノカルボン酸輸送体認識型プロドラッグ開発とその有用性Principal Investigator
- Principal Investigator
  
  細谷健一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Toyama
Transport mechanisms of cell-penetrating peptides at the blood-retinal barrier to establish strategies of macromolecular drug delivery
- Principal Investigator
  
  赤沼伸乙
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Toyama
Role of MCT9 and 14 as mechanisms of transporting cationic drugs/compounds at the blood-retinal barrier.Principal Investigator
- Principal Investigator
  
  Hosoya Ken-ichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Toyama
Influx transport system for nutrients and drugs at the blood-testis barrier and its application
- Principal Investigator
  
  Kubo Yoshiyuku
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Teikyo University
  University of Toyama
Establishing ex vivo methods to elucidate efflux transport of drugs at the blood-retinal barrier for retinal drug development
- Principal Investigator
  
  Akanuma Shin-ichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Toyama
The foundation of developing drugs for retinal diseases by pharmaceutical drug-repositioning screening based on the distribution manner via the blood-retinal barrierPrincipal Investigator
- Principal Investigator
  
  Hosoya Ken-ichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Molecular mechanisms of transport function at the BBB in epilepsy for normalizing cerebral PGE2 level
- Principal Investigator
  
  Akanuma Shin-ichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Evaluation of Cx43 proteins for PGE2 release from retinal pigment epithelial cells for understanding the pathological role in age-related macular degeneration.Principal Investigator
- Principal Investigator
  
  HOSOYA Ken-ichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Study of cationic drug efflux across the blood-retinal barrier
- Principal Investigator
  
  Kubo Yoshiyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Evaluation of cationic drug transport system at the blood-retinal barrier to deliver the drugs to the retinaPrincipal Investigator
- Principal Investigator
  
  Hosoya Ken-ichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Molecular mechanisms of prostaglandin elimination across brain barriers and its application to neural inflammatory diseasesPrincipal Investigator
- Principal Investigator
  
  HOSOYA Ken-ichi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Molecular identification and physiological role of brain-type prostaglandin transporterPrincipal Investigator
- Principal Investigator
  
  HOSOYA Ken-ichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
健全な神経発達の為に新生児の血液脳関門がもつ機能性脂質供給ルート解明と投与設計
- Principal Investigator
  
  友廣岳則
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  University of Toyama
血液網膜関門排出輸送に基づくアミロイドβ排出戦略Principal Investigator
- Principal Investigator
  
  細谷健一
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
アミノ酸トランスポーター遺伝子の転写活性調節による網膜血管新生阻害法の開発Principal Investigator
- Principal Investigator
  
  細谷健一
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
Physiological role of retina-to-blood efflux transport at the inner blood-retinal barrierPrincipal Investigator
- Principal Investigator
  
  HOSOYA Kenichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Toyama
網膜ペリサイト分泌血管内皮細胞増殖抑制因子の同定Principal Investigator
- Principal Investigator
  
  細谷健一
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Toyama Medical and Pharmaceutical University
Antioxidants transport via GLUT1 at the blood-retinal barrierPrincipal Investigator
- Principal Investigator
  
  HOSOYA Ken-ichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
cDNA cloning of blood-brain barrier neurotransmitter transporter and analysis of its physiological function
- Principal Investigator
  
  TERASAKI Tetsuya
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tohoku University
Development of new drug screening system using the blood-brain barrier transporter gene expression
- Principal Investigator
  
  TERASAKI Tetsuya
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tohoku University
Development of inner blood-retinal barrier cell lines from transgehic rats harboring temperature-sensitive SV40 large T-antigen genePrincipal Investigator
- Principal Investigator
  
  HOSOYA Ken-ichi
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Molecular analysis of cell growth regulating factor in retinal, capillary endothelial cellsPrincipal Investigator
- Principal Investigator
  
  HOSOYA Ken-ichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
血液脳関門における薬剤排出輸送系の生理的意義
- Principal Investigator
  
  TERASAKI Tetsuya
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
血液網膜関門新規実験系の開発と輸送機能解析Principal Investigator
- Principal Investigator
  
  細谷健一
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tohoku University
脈絡上皮細胞の培養細胞株の樹立
- Principal Investigator
  
  寺崎哲也
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Tohoku University
Functional multiplicity of blood-brain barrier transporters as a detoxifying system of the brain
- Principal Investigator
  
  TERASAKI Tetsuya
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  TOHOKU UNIVERSITY
Development of in vitro blood-brain barrier culture system from temperature sensitive SV40T antigen gene transgenic animal
- Principal Investigator
  
  TERASAKI Tetsuya
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  TOHOKU UNIVERSITY

[Book] Blood-brain barrier (Springer Protocols)2019
- Author(s)
  Akanuma S, Kubo Y, Hosoya K
- Total Pages
  18
- Publisher
  Humana Press
- ISBN
  9781493989454
- Data Source
  KAKENHI-PROJECT-19K07160
[Book] Imidazole Dipeptides: Chemistry, Analysis, Function and Effect2015
- Author(s)
  Kubo Y., Akanuma S., Hosoya K.
- Total Pages
  20
- Publisher
  The Royal Society of Chemistry
- Data Source
  KAKENHI-PROJECT-25293036
[Book] Vitamin transport across the blood-retinal barrier: forcus on vitamins C, E, and biotin (Handbook of Neutrition, Diet and the Eye)2014
- Author(s)
  Hosoya K., Kubo Y.
- Total Pages
  9
- Publisher
  Oxford: Academic Press-Elsevier
- Data Source
  KAKENHI-PROJECT-25293036
[Book] 薬剤学実験法必携マニュアルII2014
- Author(s)
  赤沼伸乙，細谷健一
- Total Pages
  10
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25293036
[Book] Drug Absorption Studies-In Situ, In Vitro and In Silico Models2008
- Author(s)
  K. Hosoya
- Total Pages
  696
- Publisher
  Springer
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Book] Ocular Transporters in Ophthalmic Diseases and Drug Delivery2008
- Author(s)
  K. Hosoya
- Total Pages
  467
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20659022
[Journal Article] Molecular Mechanism of SLC6A8 Dysfunction with c.1699T > C (p.S567P) Mutation in Cerebral Creatine Deficiency Syndromes2024
- Author(s)
  Jomura R、Sawada M、Tega Y、Akanuma S、Tachikawa M、Hosoya K
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 47 Issue: 1 Pages: 187-191
- DOI
  10.1248/bpb.b23-00586
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2024-01-16
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27338
[Journal Article] The structural characteristics of compounds interacting with the amantadine-sensitive drug transport system at the inner blood-retinal barrier2023
- Author(s)
  Shinozaki Y, Tega Y, Akanuma S, Hosoya K
- Journal Title
  
  Pharmaceuticals
  
  Volume: 16 Issue: 3 Pages: 435-435
- DOI
  10.3390/ph16030435
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03403
[Journal Article] Characterization of LysoTracker Red uptake by in vitro model cells of the outer blood-retinal barrier: Implication of lysosomal trapping with cytoplasmic vacuolation and cytotoxicity2023
- Author(s)
  Tega Y、Takeuchi T、Nagano M、Makino R、Kubo Y、Akanuma S、Hosoya K
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 51 Pages: 100510-100510
- DOI
  10.1016/j.dmpk.2023.100510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24043
[Journal Article] SLC6A and SLC16A family of transporters: Contribution to transport of creatine and creatine precursors in creatine biosynthesis and distribution.2022
- Author(s)
  Jomura R, Akanuma S, Tachikawa M, Hosoya K
- Journal Title
  
  Biochim. Biophys. Acta Biomembr.
  
  Volume: 1864 Issue: 3 Pages: 183840-183840
- DOI
  10.1016/j.bbamem.2021.183840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03403
[Journal Article] Differences in cerebral distribution between imipramine and paroxetine via membrane transporters at the rat blood-brain barrier.2022
- Author(s)
  Akanuma S, Han M, Murayama Y, Kubo Y, Hosoya K
- Journal Title
  
  Pharm. Res.
  
  Volume: 39 Issue: 2 Pages: 223-237
- DOI
  10.1007/s11095-022-03179-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07160, KAKENHI-PROJECT-20H03403
[Journal Article] Role of the Blood-Retinal Barrier Transporters: Antiaging in Retina2021
- Author(s)
  Hosoya K, Akanuma S, Kubo Y
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 141 Issue: 12 Pages: 1319-1325
- DOI
  10.1248/yakushi.21-00158-2
- NAID
  130008123218
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2021-12-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03403
[Journal Article] Participation of Monocarboxylate Transporter 8, But Not P-Glycoprotein, in Carrier-Mediated Cerebral Elimination of Phenytoin across the Blood-Brain Barrier2021
- Author(s)
  Jomura Ryuta、Akanuma Shin-ichi、Bauer Bjorn、Yoshida Yukiko、Kubo Yoshiyuki、Hosoya Ken-ichi
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 38 Issue: 1 Pages: 113-125
- DOI
  10.1007/s11095-021-03003-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07160
[Journal Article] Inflammation-Induced Attenuation of Prostaglandin D2 Elimination across Rat Blood–Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug Resistance-Associated Protein 42020
- Author(s)
 Akanuma Shin-ichi、Hashimoto Kahori、Yoshida Yukiko、Kubo Yoshiyuki、Hosoya Ken-ichi
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 43 Issue: 11 Pages: 1669-1677
- DOI
 10.1248/bpb.b20-00388
- NAID
 130007934042
- ISSN
 0918-6158, 1347-5215
- URL
 https://localhost/en/publications/20622a48-e489-4738-ae85-9c6f64327e53
- Year and Date
 2020-11-01
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19K07160
[Journal Article] Characteristics of Hemichannel-Mediated Substrate Transport in Human Retinal Pigment Epithelial Cells under Deprivation of Extracellular Ca2+2020
- Author(s)
 Maruyama Souhei、Akanuma Shin-ichi、Kubo Yoshiyuki、Hosoya Ken-ichi
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 43 Issue: 8 Pages: 1241-1247
- DOI
 10.1248/bpb.b20-00290
- NAID
 130007883815
- ISSN
 0918-6158, 1347-5215
- URL
 https://pure.teikyo.jp/en/publications/63742153-5fa5-4166-a6a6-52d0104b3e0a
- Year and Date
 2020-08-01
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19K07160
[Journal Article] Role of L-type amino acid transporter 1 at the inner blood-retinal barrier in the Blood-to-Retina Transport of Gabapentin2018
- Author(s)
  Akanuma Shin-ichi、Yamakoshi Atsuko、Sugouchi Takeshi、Kubo Yoshiyuki、Hartz Anika M. S.、Bauer Bjoern、Hosoya Ken-ichi
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 15 Issue: 6 Pages: 2327-2337
- DOI
  10.1021/acs.molpharmaceut.8b00179
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05110, KAKENHI-PROJECT-16K08365
[Journal Article] Multiple Cellular Transport and Binding Processes of Unesterified Docosahexaenoic Acid in Outer Blood–Retinal Barrier Retinal Pigment Epithelial Cells2018
- Author(s)
  Tachikawa M、Akanuma S、Imai T、Okayasu S、Tomohiro T、Hatanaka Y、Hosoya K
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 9 Pages: 1384-1392
- DOI
  10.1248/bpb.b18-00185
- NAID
  130007479893
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-09-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05110
[Journal Article] Influx Transport of Cationic Drug at the Blood–Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants2017
- Author(s)
  Kubo Yoshiyuki、Akanuma Shin-ichi、Hosoya Ken-ichi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 8 Pages: 1139-1145
- DOI
  10.1248/bpb.b17-00090
- NAID
  130005876324
- ISSN
  0918-6158, 1347-5215
- URL
  https://localhost/en/publications/f01492df-d0b0-4df1-8648-178065e1a344
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08409, KAKENHI-PROJECT-16H05110
[Journal Article] Blood-to-retina transport of riboflavin via RFVTs at the inner blood-retinal barrier2017
- Author(s)
  Kubo Y, Yahata S, Miki S, Akanuma S, Hosoya K
- Journal Title
  
  Drug Metab. Pharmacokinet
  
  Volume: 32 Issue: 1 Pages: 92-99
- DOI
  10.1016/j.dmpk.2016.09.006
- NAID
  210000188794
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460193
[Journal Article] Involvement of Carrier-Mediated Transport at the Blood–Cerebrospinal Fluid Barrier in Spermine Clearance from Rat Brain2017
- Author(s)
  Akanuma S., Shimada H., Kubo Y., Hosoya K.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 9 Pages: 1599-1603
- DOI
  10.1248/bpb.b17-00394
- NAID
  130006038783
- ISSN
  0918-6158, 1347-5215
- URL
  https://localhost/en/publications/ad60d432-2414-40e1-8657-91dda4aab624
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08365, KAKENHI-PROJECT-16K15157
[Journal Article] Lysosomal Trapping Is Present in Retinal Capillary Endothelial Cells: Insight into Its Influence on Cationic Drug Transport at the Inner Blood–Retinal Barrier2016
- Author(s)
  Kubo Y, Seko N, Usui T, Akanuma S, Hosoya K
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 8 Pages: 1319-1324
- DOI
  10.1248/bpb.b16-00140
- NAID
  130005254679
- ISSN
  0918-6158, 1347-5215
- URL
  https://localhost/en/publications/50b9799c-3650-4b48-b36f-3f502839eb76
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460193
[Journal Article] Impact of SLC6A Transporters in Physiological Taurine Transport at the Blood–Retinal Barrier and in the Liver2016
- Author(s)
  Kubo Y, Akanuma S, Hosoya K
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 12 Pages: 1903-1911
- DOI
  10.1248/bpb.b16-00597
- NAID
  130005171493
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05110, KAKENHI-PROJECT-26460193
[Journal Article] Beta-2 Adrenergic Agonists Are Substrates and Inhibitors of Human Organic Cation Transporter 1.2015
- Author(s)
  Salomon J.J., Hagos Y., Petzke S., Kühne A., Gausterer J.C., Hosoya K., Ehrhardt C.
- Journal Title
  
  Mol. Pharm.
  
  Volume: 12 Issue: 8 Pages: 2633-41
- DOI
  10.1021/mp500854e
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293036
[Journal Article] Impact of Cationic Amino Acid Transporter 1 on Blood-Retinal Barrier Transport of L-Ornithine.2015
- Author(s)
  Kubo Y, Obata A, Akanuma S, Hosoya K
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 56 Issue: 10 Pages: 5925-32
- DOI
  10.1167/iovs.15-17398
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460193, KAKENHI-PROJECT-25293036
[Journal Article] Organic cation transporter function in different in vitro models of human lung epithelium.2015
- Author(s)
  Salomon J.J., Gausterer J.C., Yahara T., Hosoya K., Huwer H., Hittinger M., Schneider-Daum N., Lehr C.M., Ehrhardt C.
- Journal Title
  
  Eur. J. Pharm. Sci.
  
  Volume: 80 Pages: 82-8
- DOI
  10.1016/j.ejps.2015.08.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293036
[Journal Article] Functional characterization of carrier-mediated transport of pravastatin across the blood-retinal barrier in rats.2015
- Author(s)
  Fujii S., Setoguchi C., Kawazu K., Hosoya K.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 43 Issue: 12 Pages: 1956-9
- DOI
  10.1124/dmd.115.066266
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293036
[Journal Article] Excitatory Amino Acid Transporter 1-Mediated L-Glutamate Transport at the Inner Blood–Retinal Barrier: Possible Role in L-Glutamate Elimination from the Retina2015
- Author(s)
  Sakurai T., Akanuma S., Usui T., Kubo Y., Tachikawa M., Hosoya K
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 7 Pages: 1087-1091
- DOI
  10.1248/bpb.b15-00226
- NAID
  130005086298
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293036
[Journal Article] In Vitro Study of L-Glutamate and L-Glutamine Transport in Retinal Pericytes: Involvement of Excitatory Amino Acid Transporter 1 and Alanine–Serine–Cysteine Transporter 22015
- Author(s)
 Akanuma S., Zakoji N., Kubo Y., Hosoya K.
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 38 Issue: 6 Pages: 901-908
- DOI
 10.1248/bpb.b15-00133
- NAID
 130005072672
- ISSN
 0918-6158, 1347-5215
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-25293036
[Journal Article] Involvement of Cationic Amino Acid Transporter 1 in L-Arginine Transport in Rat Retinal Pericytes2015
- Author(s)
  Zakoji N., Akanuma S., Tachikawa M., Hosoya K.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 2 Pages: 257-262
- DOI
  10.1248/bpb.b14-00637
- NAID
  130004872256
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293036
[Journal Article] Distribution of microsomal prostaglandin E synthase-1 in the mouse brain2014
- Author(s)
  Eskilsson A., Tachikawa M., Hosoya K., Blomqvist A.
- Journal Title
  
  J. Comp. Neurol.
  
  Volume: (印刷中) Issue: 14 Pages: 3229-3244
- DOI
  10.1002/cne.23593
- Year and Date
  2014-04-08
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659072
[Journal Article] Impact of P-glycoprotein on blood-retinal barrier permeability: comparison of blood-aqueous humor and blood-brain barrier using mdr1a knockout rats.2014
- Author(s)
  Fujii S., Setoguchi C., Kawazu K., Hosoya K.
- Journal Title
  
  Invest. Ophthalmol. Vis. Sci.
  
  Volume: 55 Issue: 7 Pages: 4650-8
- DOI
  10.1167/iovs.13-13819
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293036
[Journal Article] Localization of organic anion transporting polypeptide (Oatp) 1a4 and Oatp1c1 at the rat blood-retinal barrier.2013
- Author(s)
  Akanuma S., Hirose S., Tachikawa M., Hosoya K.
- Journal Title
  
  Fluids Barriers CNS
  
  Volume: 10 Issue: 1 Pages: 29-29
- DOI
  10.1186/2045-8118-10-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790148, KAKENHI-PROJECT-25293036
[Journal Article] Involvement of a novel organic cation transporter in verapamil transport across the inner blood retinal barrier2013
- Author(s)
  Kubo Y, Kusagawa Y, Tachikawa M, Akanuma S, Hosoya K
- Journal Title
  
  PharmaceuticalResearch
  
  Volume: 30 Issue: 3 Pages: 847-56
- DOI
  10.1007/s11095-012-0926-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890066, KAKENHI-PROJECT-25293036
[Journal Article] カチオン性薬物輸送に見る血液網膜関門と血液脳関門の類似と相違2013
- Author(s)
  久保義行、赤沼伸乙、細谷健一
- Journal Title
  
  細胞工学
  
  Volume: 32 Pages: 950-954
- Data Source
  KAKENHI-PROJECT-25293036
[Journal Article] The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage.2013
- Author(s)
  Sugitani S
- Journal Title
  
  Exp Eye Res
  
  Volume: Sep 26 Pages: 135-42
- DOI
  10.1016/j.exer.2013.06.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791493, KAKENHI-PROJECT-25293036
[Journal Article] Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E2 produced in the brain.2012
- Author(s)
  Tachikawa M
- Journal Title
  
  J Neurochem
  
  Volume: 123 Issue: 5 Pages: 750-760
- DOI
  10.1111/jnc.12018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005, KAKENHI-PROJECT-24659072
[Journal Article] A clearance system for prostaglandin D2, a sleep-promoting factor, in the cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters.2012
- Author(s)
  Tachikawa M
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 343 Issue: 3 Pages: 608-616
- DOI
  10.1124/jpet.112.197012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689005, KAKENHI-PROJECT-24659072
[Journal Article] Transport systems of serine at the brain barriers and in brain parenchymal cells2011
- Author(s)
  Kasai Y., Tachikawa M., Hirose S., Akanuma S., Hosoya K.
- Journal Title
  
  J. Neurochem
  
  Volume: 118 Issue: 2 Pages: 304-13
- DOI
  10.1111/j.1471-4159.2011.07313.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-22689005
[Journal Article] Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins2011
- Author(s)
  Hosoya K., Tachikawa M.
- Journal Title
  
  Clin. Exp. Nephrol.
  
  Volume: 15 Issue: 4 Pages: 478-85
- DOI
  10.1007/s10157-011-0460-y
- NAID
  10029571602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042
[Journal Article] Attenuation of prostaglandin E_2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole2011
- Author(s)
  Akanuma S., Uchida Y., Ohtsuki S., Kamiie J., Tachikawa M., Terasaki T., Hosoya K.
- Journal Title
  
  Fluids Barriers CNS
  
  Volume: 8 Issue: 1 Pages: 24-24
- DOI
  10.1186/2045-8118-8-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-22790150, KAKENHI-PROJECT-23790170
[Journal Article] Molecular-weight-dependent, Anionic-substrate-preferential Transport of .BETA.-Lactam Antibiotics via Multidrug Resistance-associated Protein 42011
- Author(s)
  Akanuma S., Uchida Y., Ohtsuki S., Kamiie J., Tachikawa M., Terasaki T., Hosoya K.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Issue: 6 Pages: 602-611
- DOI
  10.2133/dmpk.DMPK-11-RG-063
- NAID
  130004933500
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-22790150, KAKENHI-PROJECT-23790170
[Journal Article] Amyloid-βpeptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier2011
- Author(s)
  Fujiyoshi M., Tachikawa M., Ohtsuki S., Ito S., Uchida Y., Akanuma S., Kamiie J., Hashimoto T., Hosoya K., Iwatsubo T., Terasaki T.
- Journal Title
  
  J. Neurochem.
  
  Volume: 118 Issue: 3 Pages: 407-15
- DOI
  10.1111/j.1471-4159.2011.07311.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-23790170
[Journal Article] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders2011
- Author(s)
  Tachikawa M., Hosoya K.
- Journal Title
  
  Fluids Barriers CNS
  
  Volume: 8 Issue: 1 Pages: 13-13
- DOI
  10.1186/2045-8118-8-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042
[Journal Article] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders.2011
- Author(s)
  Tachikawa M., Hosoya K.
- Journal Title
  
  Fluids Barriers CNS
  
  Volume: 8 Pages: 1-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042
[Journal Article] Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E_2 across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins2010
- Author(s)
  Akanuma S., Hosoya K., Ito S., Tachikawa M., Terasaki T, Ohtsuki S.
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: 333 Issue: 3 Pages: 912-9
- DOI
  10.1124/jpet.109.165332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042, KAKENHI-PROJECT-22790150
[Journal Article] Lipophilicity and transporter influence on blood-retinal barrier permeability : a comparison with blood-brain barrier permeability.2010
- Author(s)
  Hosoya K., et al.
- Journal Title
  
  Pharm.Res.
  
  Volume: 27 Pages: 2715-2724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042
[Journal Article] Lipophilicity and transporter influence on blood-retinal barrier permeability : a comparison with blood-brain barrier permeability2010
- Author(s)
  Hosoya K., Yamamoto A., Akanuma S., Tachikawa M.
- Journal Title
  
  Pharm. Res
  
  Volume: 27 Issue: 12 Pages: 2715-24
- DOI
  10.1007/s11095-010-0272-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390042
[Journal Article] Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells2008
- Author(s)
  M, Tachikawa, H, Toki, M, Tomi, K, Hosoya
- Journal Title
  
  Microvasc. Res 75
  
  Pages: 68-72
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Inner blood-retinal barrier: transport biology and methodology2008
- Author(s)
  K, Hosoya, M, Tomi
- Journal Title
  
  Drug Absorption Studies-In Situ, In Vitro and In Silico Models, C. Ehrhardt and K.J. Kim(Ed) AAPS Press-Springer, New York
  
  Pages: 321-338
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Na^+-independent choline transport in rat retinal capillary endothelial cells2007
- Author(s)
  M, Tomi, K, Arai, M, Tachikawa, K, Hosoya
- Journal Title
  
  Neurochem. Res 32
  
  Pages: 1833-1842
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Functional involvement of scavenger receptor class B, type I, in the uptake of a-tocopherol using cultured rat retinal capillary endothelial cells2007
- Author(s)
  M, Tachikawa, S, Okayasu, K, Hosoya
- Journal Title
  
  Mol. Vis 13
  
  Pages: 2041-2047
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation2006
- Author(s)
  K, Ikesugi, M.L, Mulhern, C. J, Madson, K, Hosoya, T, Terasaki ,P. K. Kador, T. Shinohara
- Journal Title
  
  Curr. Eye Res 31
  
  Pages: 947-953
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Inhibition of dehydroascorbic acid transport across the rat blood-retinal and -brain barriers in experimental diabetes2006
- Author(s)
  A. Minamizono, M, Tomi, K, Hosoya
- Journal Title
  
  Biol. Pharm. Bull 29
  
  Pages: 2148-2150
- NAID
  110004810310
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier2006
- Author(s)
  K, Nagase, M, Tomi, M, Tachikawa, K, Hosoya
- Journal Title
  
  Biochim. Biophys. Acta 1758
  
  Pages: 13-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Application of microdialysis to evaluate the efflux transport of estradiol 17-β glucuronide across the rat blood-retinal barrier2006
- Author(s)
  K, Katayama, Y, Ohshima, M, Tomi, K, Hosoya
- Journal Title
  
  J. Neurosci. Methods 156
  
  Pages: 249-256
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Functional and regulation of taurine transport at the inner blood-retinal barrier2006
- Author(s)
  M, Tomi, T, Terayama, T, Isobe, F, Egami, A. Morito, M, Kurachi, S, Ohtsuki, Y. S, Kang, T, Terasaki, K, Hosoya
- Journal Title
  
  Microvasc. Res 73
  
  Pages: 100-106
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Journal Article] Advanced in the cell biology of transport vis the inner blood-retinal barrier : establishment of cell lines and transport functions2005
- Author(s)
  K.Hosoya
- Journal Title
  
  Biol.Pharm.Bull. 28
  
  Pages: 1-8
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] Advances in the cell biology of transport via the inner blood-retinal barrier : establishment of cell lines and transport functions2005
- Author(s)
  K.Hosoya
- Journal Title
  
  Biol.Pharm.Bull. 28
  
  Pages: 1-8
- NAID
  10016658293
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] Advances in the cell biology of transport via the inner blood-retinal barrier : establishment of cell lines and transport functions2005
- Author(s)
  K.Hosoya, M.Tomi
- Journal Title
  
  Biol.Pharm.Bull. 28
  
  Pages: 1-8
- NAID
  10016658293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] Downregulation of retinal GLUT1 in diabetes by ubiquitinylation2004
- Author(s)
  R.Fernandes, A.L.Carvalho, A.Kumagai, R.Seica, K.Hosoya, T.Terasaki, J.Murta, P.Pereira, C.Faro
- Journal Title
  
  Mol.Vis. 10
  
  Pages: 618-628
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier2004
- Author(s)
  T.Nakashima, M.Tomi, K.Katayama, M.Tachikawa, M.Watanabe, T.Terasaki, K.Hosoya
- Journal Title
  
  J.Neurochem. 89
  
  Pages: 1454-1461
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] Application of magnetically isolated rat retinal vascular endothelial cells for the determination of transporter gene expression levels at the inner blood-retinal barrier2004
- Author(s)
  M.Tomi, K.Hosoya
- Journal Title
  
  J.Neurochem. 91
  
  Pages: 1244-1248
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] Vitamin C transport in oxidized form across the rat blood-retinal barrier2004
- Author(s)
  K.Hosoya, A.Minamizono, K.Katayama, T.Terasaki, M.Tomi
- Journal Title
  
  Invest.Ophthalmol.Vis.Sci. 45
  
  Pages: 1232-1239
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] Vitamin C transport in oxidized form across the rat blood-retinal barrier2004
- Author(s)
  K.Hosoya
- Journal Title
  
  Invest.Ophthalmol.Vis.Sci. 45
  
  Pages: 1232-1239
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] In vitro study of the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate2003
- Author(s)
  S.Ohtsuki, T.Takizawa, H.Takanaga, N.Terasaki, T.Kitazawa, M.Sasaki, T.Abe, K.Hosoya, T.Terasaki
- Journal Title
  
  Mol.Pharmacol. 63
  
  Pages: 532-537
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] Establishment of conditionally immortalized rat retinal pericyte cell lines (TR-rPCT) and their application in a co-culture system using retinal capillary endothelial cell line (TR-iBRB2)2003
- Author(s)
  T.Kondo, K.Hosoya, S.Hori, M.Tomi, S.Ohtsuki, H.Takanaga, E.Nakashima, H.Iizasa, T.Asashima, M.Ueda, M.Obinata, T.Terasaki
- Journal Title
  
  Cell Struct.Funct. 28
  
  Pages: 145-153
- NAID
  10011619370
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] Organic anion transporter 3 is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of rat brain capillary endothelial cells2003
- Author(s)
  S.Mori, H.Takanaga, S.Ohtsuki, T.Deguchi, Y.S.Kang, K.Hosoya, T.Terasaki
- Journal Title
  
  J.Cereb.Blood Flow Metab. 23
  
  Pages: 432-440
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] Expression and regulation of L-cystine transporter, system x_c, in the newly developed rat retinal Muller cell line (TR-MUL)2003
- Author(s)
  M.Tomi, T.Funaki, H.Abukawa, K.Katayama, T.Kondo, S.Ohtsuki, M.Ueda, M.Obinata, T.Terasaki, K.Hosoya
- Journal Title
  
  Glia 43
  
  Pages: 208-217
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] Recombinant arginine deiminase as a differential modulator of inducible (iNOS) and endothelial (eNOS) nitric oxide synthetase activity in cultured endothelial cells2003
- Author(s)
  L.Shen, W.Lin, K.Beloussow, K.Hosoya, T.Terasaki, D.K.Ann, W.C.Shen
- Journal Title
  
  Biochem.Pharmacol 66
  
  Pages: 1945-1952
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Journal Article] New approaches to in vitro models of the blood-brain barrier drug transport2003
- Author(s)
  T.Terasaki, S.Ohtsuki, S.Hori, H.Takanaga, E.Nakashima, K.Hosoya
- Journal Title
  
  Drug Discov.Today 8
  
  Pages: 944-954
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390046
[Presentation] 糖尿病模倣条件下による内側血液網膜関門多細胞性スフェロイドの物質輸送機能変化2024
- Author(s)
  吉崎美沙, 赤沼伸乙, 手賀悠真, 細谷健一
- Organizer
  日本薬学会第144回年会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] ヒト脳毛細血管内皮細胞株におけるtaurine輸送機構の特徴2024
- Author(s)
  川内裕介, 手賀悠真, 赤沼伸乙, 細谷健一
- Organizer
  日本薬学会第144回年会
- Data Source
  KAKENHI-PROJECT-23K27338
[Presentation] 糖尿病モデルにおけるラット内側血液網膜関門P-糖タンパク質の機能変化2023
- Author(s)
  林茉里乃, 赤沼伸乙, 田嶋孝亮, 遠藤広樹, 久保義行, 細谷健一
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] リポ多糖が誘発するラット内側血液網膜関門P-糖タンパク質の機能減弱メカニズム解明2023
- Author(s)
  大小原清貴, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] Evaluation of altering tight-junctions and drug efflux transporters by advanced glycation end-products with newly established in vitro rat blood-brain barrier spheroids2023
- Author(s)
  Endo H, Ogasawara M, Akanuma S, Tega Y, Kubo Y, Hosoya K
- Organizer
  7th Toyama-Basel Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] hCMEC/D3細胞におけるtaurine輸送特性2023
- Author(s)
  川内裕介, 手賀悠真, 赤沼伸乙, 稲垣舞, 立川正憲, 細谷健一
- Organizer
  日本薬学会北陸支部第135回例会
- Data Source
  KAKENHI-PROJECT-23K27338
[Presentation] 脈絡叢上皮細胞におけるグアニジノ酢酸からのクレアチン生合成と脳脊髄液中へのMCT12を介したクレアチン排出輸送2023
- Author(s)
  定村龍太, 赤沼伸乙, 久保義行, 立川正憲, 細谷健一
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] ヒト脳毛細血管内皮細胞株hCMEC/D3細胞におけるcreatine輸送の特徴2023
- Author(s)
  繁昌志帆, 手賀悠真, 赤沼伸乙, 久保義行, 稲垣舞, 立川正憲, 細谷健一
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 糖尿病環境模倣条件下の内側血液網膜関門スフェロイドにおける物質輸送機能変動2023
- Author(s)
  吉崎美沙, 手賀悠真, 赤沼伸乙, 細谷健一
- Organizer
  日本薬学会北陸支部第135回例会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] ラット網膜色素上皮細胞におけるangiopep-2輸送特性の解析2023
- Author(s)
  松原崚也, 今秀輝, 手賀悠真, 赤沼伸乙, 細谷健一
- Organizer
  日本薬学会北陸支部第135回例会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] 内側血液網膜関門P-glycoproteinの糖尿病条件下における機能低下2023
- Author(s)
  赤沼伸乙, 林　茉里乃, 田嶋孝亮, 遠藤広樹, 久保義行, 細谷健一
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] Mechanisms of lipopolysaccharide-induced functional alteration of P-glycoprotein at the inner blood-retinal barrier elucidated by ex vivo transport analysis2023
- Author(s)
  Daikohara K, Akanuma S, Tega Y, Kubo Y, Hosoya K
- Organizer
  7th Toyama-Basel Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] ラット内側血液網膜関門におけるグルタミン酸受容体を介した8-[fluo]-cAMP輸送機能変動2023
- Author(s)
  神家茉朋, 赤沼伸乙, 手賀悠真, 細谷健一
- Organizer
  日本薬学会北陸支部第135回例会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] Functional change in P-glycoprotein at the inner blood-retinal barrier, formed by retinal capillaries, in diabetic models in vivo2023
- Author(s)
  Akanuma S, Hayashi M, Tajima K, Endo H, Tega Y, Kubo Y, Hosoya K
- Organizer
  2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenbiotics in Shizuoka
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] リポ多糖が誘発するラット内側血液網膜関門P-糖タンパク質の機能減弱メカニズム解明2023
- Author(s)
  大小原清貴, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 網膜への高分子送達に向けた関門突破型ペプチドの輸送機構とその評価系構築2023
- Author(s)
  赤沼伸乙, 久保　義行, 細谷　健一
- Organizer
  日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] 脈絡叢上皮細胞におけるクレアチン生合成とMCT12を介したクレアチンの脳脊髄液への排出輸送2023
- Author(s)
  定村龍太, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-23K27338
[Presentation] Tight junctions and transporters in newly-developed inner blood-retinal barrier spheroids constructed by conditionally-immortalized rat cell lines2023
- Author(s)
  Akanuma S, Yamamoto Y, Kon H, Endo H, Kubo Y, Hosoya K
- Organizer
  Cerebral Vascular Biology 14th International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion to creatine and MCT12-mediated efflux transport of creatine2023
- Author(s)
  Jomura R, Akanuma S, Tachikawa M, Hosoya K
- Organizer
  Cerebral Vascular Biology 14th International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27338
[Presentation] 内側血液網膜関門におけるモノカルボン酸トランスポーター14の発現・機能2022
- Author(s)
  横川瑞葵, 福永飛自幾, 定村龍太, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬学会北陸支部第134回例会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 血液精巣関門における担体介在型nicotine輸送の特徴2022
- Author(s)
  久保義行、清水雄斗、赤沼伸乙、細谷健一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07173
[Presentation] ラット内側血液網膜関門におけるリポ多糖誘発性P-糖タンパク質の機能変動2022
- Author(s)
  大小原清貴, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] 脈絡叢から脳脊髄液へのMCT12を介したクレアチン輸送2022
- Author(s)
  定村龍太, 赤沼伸乙, 立川正憲, 細谷健一
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] ラット単離網膜毛細血管を用いた内側血液網膜関門P-糖タンパク質機能変動メカニズムの解明2022
- Author(s)
  大小原清貴, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬学会北陸支部第134回例会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 内皮透過型細胞膜透過ペプチドangiopep-2の内側血液網膜関門における輸送様式2022
- Author(s)
  赤沼伸乙, 今秀輝, 原啓太, 久保義行, 細谷健一
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] ストレプトゾトシン誘発性糖尿病ラット血液脳関門のP-gpおよびBCRP輸送機能変化の解明2022
- Author(s)
  遠藤広樹, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] ラット血液脳関門多細胞性スフェロイドモデルの確立2022
- Author(s)
  小笠原美希、赤沼伸乙、今秀輝、久保義行、細谷健一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 糖尿病モデル内側血液網膜関門におけるP-glycoproteinの発現機能変化2022
- Author(s)
  林茉里乃, 田嶋孝亮, 遠藤広樹, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬学会北陸支部第134回例会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] ラット内側血液網膜関門におけるリポ多糖誘発性P-糖タンパク質の機能変動2022
- Author(s)
  大小原清貴, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 血液網膜関門を介したamantadineの網膜への輸送特性2022
- Author(s)
  篠崎友亮、赤沼伸乙、森唯衣香、久保義行、細谷健一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] ラット単離網膜毛細血管を用いた内側血液網膜関門P-糖タンパク質機能変動メカニズムの解明2022
- Author(s)
  大小原清貴, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬学会北陸支部第134回例会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] リポ多糖処理による内側血液網膜関門P-糖タンパク質の機能変動2022
- Author(s)
  大小原清貴, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] 細胞膜透過性ペプチドであるangiopep-2の内側血液網膜関門を介した輸送の特性2022
- Author(s)
  今秀輝, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] ヒト血液脳関門モデル細胞におけるcreatine輸送特性2022
- Author(s)
  繁昌志帆, 赤沼伸乙, 久保義行, 稲垣舞, 立川正憲, 細谷健一
- Organizer
  日本薬学会北陸支部第134回例会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 細胞膜透過性ペプチドangiopep-2付加による内側血液網膜関門の物質透過性向上とその輸送機構解析2022
- Author(s)
  今秀輝、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 糖尿病病態時のラット血液脳関門におけるABCトランスポーターの機能変動2022
- Author(s)
  遠藤広樹, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-23K24043
[Presentation] ラット血液脳関門におけるABCトランスポーターのストレプトゾトシン誘発型糖尿病モデルにおける変化とその要因2022
- Author(s)
  遠藤広樹、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] リポ多糖処理による内側血液網膜関門P-糖タンパク質の機能変動2022
- Author(s)
  大小原清貴, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 糖尿病ラット脳毛細血管におけるABCトランスポーター輸送機能変動とその要因の解明2021
- Author(s)
  遠藤広樹、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬学会北陸支部第133回例会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] In vivo薬物輸送特性の評価を目的とした多細胞性ラット血液網膜関門スフェロイドの確立2021
- Author(s)
  山本　雄大、赤沼　伸乙、久保　義行、細谷　健一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 脳・網膜関門の薬物輸送分子機構理解に向けた2種のin vitroモデル開発：単離毛細血管と多細胞性スフェロイド2021
- Author(s)
  赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 血液網膜関門におけるトランスポーター：網膜のアンチエイジング2021
- Author(s)
  細谷　健一、赤沼　伸乙、久保　義行
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] アマンタジンの網膜分布に関与する血液網膜関門輸送機構2021
- Author(s)
  篠崎友亮、赤沼伸乙、森唯衣香、久保義行、細谷健一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] In vitro多細胞性ラット血液脳関門スフェロイドの構築とその特性2021
- Author(s)
  小笠原美希、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬学会北陸支部第133回例会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 血液精巣関門 (BTB) における3’-Azido-3’-deoxythymidine (AZT) 輸送機構2021
- Author(s)
  伊藤　武、久保義行、赤沼伸乙、細谷健一
- Organizer
  日本薬物動態学会第36年会
- Data Source
  KAKENHI-PROJECT-20K07173
[Presentation] 内側血液網膜関門における細胞膜透過性ペプチドangiopep-2輸送2021
- Author(s)
  今秀輝、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬学会北陸支部第133回例会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 血液網膜関門を介した網膜へのamantadine輸送2021
- Author(s)
  篠崎友亮、赤沼伸乙、森唯衣香、久保義行、細谷健一
- Organizer
  日本薬学会北陸支部第133回例会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] Monocarboxylate transporter 12 (MCT12) contributes to process of creatine biosynthesis as an efflux transporter of creatine and guanidinoacetate in the kidney and liver.2021
- Author(s)
  Jomura R, Tanno Y, Akanuma S, Kubo Y, Tachikawa M, Hosoya K
- Organizer
  2021 CSPS/PSJ/CC-CRS Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 肝臓におけるクレアチン排出に対するMCT12の関与2021
- Author(s)
  定村龍太、丹野優、赤沼伸乙、久保義行、立川正憲、細谷健一
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 血液精巣関門におけるnicotineの輸送特性2021
- Author(s)
  清水雄斗、久保義行、赤沼伸乙、細谷健一
- Organizer
  日本薬学会北陸支部第133回例会
- Data Source
  KAKENHI-PROJECT-20K07173
[Presentation] 血液網膜関門におけるamantadine取り込み解析2021
- Author(s)
  篠崎友亮、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] ラット網膜色素上皮細胞における薬物のin vitroリソソーム隔離の特性2021
- Author(s)
  赤沼　伸乙、永野　正敏、牧野　令奈、竹内　駿徳、久保　義行、細谷　健一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] Monocarboxylate transporter 12 (MCT12) mediates efflux transport of guanidinoacetate and creatine in the process of endogenous creatine supply in the kidney and liver.2021
- Author(s)
  Jomura R, Tanno Y, Akanuma S, Kubo Y, Tachikawa M, Hosoya K
- Organizer
  6th Toyama-Basel Joint Symposium 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 条件的不死化ラット血液脳関門スフェロイドにおける密着結合及び薬物輸送担体の発現・機能2021
- Author(s)
  赤沼伸乙、小笠原美希、今秀輝、久保義行、細谷健一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 血液網膜関門を介した循環血液からの網膜へのamantadine輸送2021
- Author(s)
  篠崎友亮、赤沼伸乙、森唯衣香、久保義行、細谷健一
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 新たな血液網膜関門輸送研究手法の開発に基づく本関門を介した血液-網膜間薬物動態の制御分子機構解明2021
- Author(s)
  細谷健一
- Organizer
  日本薬物動態学会第36回年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] In vitroラット内側血液網膜関門3次元スフェロイドモデルにおける密着結合・薬物輸送担体の機能2020
- Author(s)
  赤沼　伸乙、山本　雄大、久保　義行、細谷　健一
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 眼科製剤を考えるための薬物動態：眼内薬物動態に関わるトランスポーター2020
- Author(s)
  細谷　健一、赤沼　伸乙、久保　義行
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 血液網膜関門カチオン性薬物輸送に対するリソソーム内薬物取り込みの影響2020
- Author(s)
  久保　義行、山田　未希、赤沼　伸乙、細谷　健一
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] トランスポーター介在薬物輸送機能を保持したラット単離網膜毛細血管単離法の確立2020
- Author(s)
  田嶋　孝亮、赤沼　伸乙、吉田　有紀子、大石　雄基、久保　義行、井上　将彦、細谷　健一
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 血液網膜関門機能と薬物網膜移行に関する生物薬剤学的研究2020
- Author(s)
  細谷　健一
- Organizer
  日本薬剤学会第35年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] ABCトランスポーターの機能評価に向けた網膜毛細血管の単離法確立2020
- Author(s)
  田嶋孝亮, 赤沼伸乙, 大石雄基, 久保義行, 井上将彦, 細谷健一
- Organizer
  日本薬学会第140年会 (京都)
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 血液網膜関門における薬物輸送機構：飲む目薬開発に向けて2020
- Author(s)
  細谷　健一
- Organizer
  第31回日本緑内障学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03403
[Presentation] 単離網膜毛細血管におけるABCトランスポーターの機能評価法2019
- Author(s)
  田嶋孝亮, 赤沼伸乙, 大石雄基, 久保義行, 井上将彦, 細谷健一
- Organizer
  日本薬学会北陸支部第131回例会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 生体における薬物輸送特性評価のための内側血液網膜関門多細胞性スフェロイドモデルの確立2019
- Author(s)
  山本雄大, 細谷健一, 久保義行, 赤沼伸乙
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] In vivo薬物輸送特性の評価を目的としたラット血液網膜関門スフェロイドモデルの確立2019
- Author(s)
  山本雄大, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬学会北陸支部第131回例会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 単離網膜毛細血管におけるABCトランスポーターの機能評価法2019
- Author(s)
  田嶋孝亮, 赤沼伸乙, 大石雄基, 久保義行, 井上将彦, 細谷健一
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 血液網膜関門を介したgabapentin輸送におけるL型アミノ酸トランスポーター1の役割2019
- Author(s)
  赤沼　伸乙、山腰　敦子、須河内　剛志、久保　義行、Anika M.S. Hartz、Bjoern Bauer、細谷　健一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] ラット網膜色素上皮細胞におけるカチオン性薬物リソソーム隔離の特徴2019
- Author(s)
  赤沼伸乙, 牧野令奈, 永野正敏, 久保義行, 細谷健一
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-19K07160
[Presentation] 血液脳関門を介した脳へのgabapentin輸送におけるL型アミノ酸トランスポーター1（LAT1）の関与2019
- Author(s)
  須河内　剛志、赤沼　伸乙、久保　義行、Anika M.S. Hartz、Bjoern Bauer、細谷　健一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] 単離脳毛細血管を用いた血液脳関門におけるアニオン輸送機構変動解析2019
- Author(s)
  吉田　有紀子、赤沼　伸乙、久保　義行、細谷　健一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] ラット血液脳関門を介したimipramine輸送機構解明2019
- Author(s)
  韓　明来、赤沼　伸乙、久保　義行、細谷　健一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] Localization of monocarboxylate transporter 12 as a facilitative creatine transporter in rat choroid plexus and retinal pigment epithelium2018
- Author(s)
  Jomura R, Tanno Y, Akanuma S, Tachikawa M, Kubo Y, Hosoya K
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] Study of receptor-mediated cyanocobalamin (vitamin B12) transport at the blood-retinal barrier with Cy5-labeled cyanocobalamin2018
- Author(s)
  Kubo Y, Kinoshita Y, Nogami K, Jomura R, Akanuma S, Abe H, Inouye M, Hosoya K
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] Gabapentinの網膜移行に対する血液網膜関門L型アミノ酸トランスポーターの関与2018
- Author(s)
  山腰　敦子、赤沼　伸乙、須河内　剛志、久保　義行、Anika M.S. Hartz、Bjoern Bauer、細谷　健一
- Organizer
  日本薬学会北陸支部第130回例会
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] L-Type amino acid transporter 1 at the inner and outer blood-retinal barriers mediates the blood-to-retina transport of gabapentin2018
- Author(s)
  Atsuko Yamakoshi, Shin-ichi Akanuma, Takeshi Sugouchi, Yoshiyuki Kubo, Anika M.S. Hartz, Bjoern Bauer, Ken-ichi Hosoya
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] 血液網膜関門におけるgabapentin輸送へのL型アミノ酸トランスポーター1の関与2018
- Author(s)
  赤沼　伸乙、山腰　敦子、須河内　剛志、久保　義行、Anika M.S. Hartz、Bjoern Bauer、細谷　健一
- Organizer
  富山・バーゼル医薬品研究開発シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] 網膜へのガバペンチン移行における内側血液網膜関門中性アミノ酸輸送担体LAT1の役割2018
- Author(s)
  赤沼　伸乙、山腰　敦子、須河内　剛志、久保　義行、Anika M.S. Hartz、Bjoern Bauer、細谷　健一
- Organizer
  公益社団法人日本薬剤学会　第33年会
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] 血液脳関門nicotineインフラックス輸送系への中枢神経系疾患治療薬認識性2018
- Author(s)
  細谷　健一、山﨑　雄平、手賀　悠真、赤沼　伸乙、久保　義行
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 内側血液網膜関門カチオン性薬物輸送に対する酸性小胞内蓄積機構の寄与2018
- Author(s)
  粉川　紗季、久保　義行、赤沼　伸乙、細谷　健一
- Organizer
  日本薬学会　第138年会
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] L-Type amino acid transporter-mediated blood-to-brain gabapentin transport across the blood-brain barrier2018
- Author(s)
  Takeshi Sugouchi, Shin-ichi Akanuma, Yoshiyuki Kubo, Anika M.S. Hartz, Bjoern Bauer, Ken-ichi Hosoya
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] Expression and localization of creatine synthesizing enzyme and monocarboxylate transporter 12 in rat brain and retina2018
- Author(s)
  Jomura R, Tanno Y, Akanuma S, Tachikawa M, Kubo Y, Hosoya K
- Organizer
  The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] ラット網膜色素上皮細胞におけるchloroquine過剰蓄積によるlysosome空胞化2018
- Author(s)
  牧野　令奈、赤沼　伸乙、久保　義行、細谷　健一
- Organizer
  日本薬学会　第138年会
- Data Source
  KAKENHI-PROJECT-16K15157
[Presentation] 血液脳関門モデル細胞におけるnicotine輸送に対する中枢神経系疾患治療薬の影響2018
- Author(s)
  細谷　健一、山﨑　雄平、赤沼　伸乙、久保　義行
- Organizer
  日本薬学会　第138年会
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] ラット網膜色素上皮細胞におけるchloroquine過剰蓄積によるlysosome空胞化2018
- Author(s)
  牧野　令奈、赤沼　伸乙、久保　義行、細谷　健一
- Organizer
  日本薬学会　第138年会
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] Characteristics of imipramine transport at the blood-brain barrier2018
- Author(s)
  Han M, Akanuma S, Kubo Y, Hosoya K
- Organizer
  The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] Functional heterogeneity of Oatp1a4-mediated transport in hepatocytes of rat hepatic lobules2018
- Author(s)
  Shin-ichi Akanuma, Rintaro Kida, Ai Tsuchiyama, Masanori Tachikawa, Yoshiyuki Kubo, Ken-ichi Hosoya
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] 薬剤耐性てんかんの克服に向けた血液脳関門薬物・内因性化合物輸送機構解明2018
- Author(s)
  赤沼　伸乙、久保　義行、細谷　健一
- Organizer
  日本薬学会　第138年会
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] NMDA受容体による血液脳関門を介したアニオン輸送機構変動解析2018
- Author(s)
  吉田　有紀子、赤沼　伸乙、久保　義行、細谷　健一
- Organizer
  日本薬学会北陸支部第130回例会
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] 血液脳関門におけるimipramine輸送特性解明2018
- Author(s)
  韓　明来、赤沼　伸乙、久保　義行、細谷　健一
- Organizer
  日本薬学会北陸支部第130回例会
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 内側血液網膜関門を介したcyanocobalamin取り込み輸送機構2017
- Author(s)
  久保　義行、木下　由梨、野上　暁生、阿部　肇、井上　将彦、赤沼　伸乙、細谷　健一
- Organizer
  日本薬剤学会　第32年会
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 網膜毛細血管内皮細胞における酸性小胞内蓄積機構とカチオン性薬物輸送への影響2017
- Author(s)
  粉川　紗季、赤沼　伸乙、久保　義行、細谷　健一網膜毛細血管内皮細胞における酸性小胞内蓄積機構
- Organizer
  日本薬学会北陸支部　第129回例会
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 血液脳関門を介した脳へのgabapentin輸送機構の解明2017
- Author(s)
  須河内　剛志、赤沼　伸乙、久保　義行、細谷　健一
- Organizer
  日本薬学会北陸支部　第129回例会
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] Involvement of lysosomal trapping in verapamil transport across the blood-retinal barrier2017
- Author(s)
  Ken-ichi Hosoya, Ayumi Nakazawa, Shin-ichi Akanuma, Yoshiyuki Kubo
- Organizer
  International Symposium on Drug Delivery and Pharmaceutical Sciences: Beyond the History
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2017-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] ヒト網膜色素上皮細胞における物質輸送へのヘミチャネル分子の関与2017
- Author(s)
  丸山蒼平、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬学会第137年会 (仙台)
- Place of Presentation
  仙台市 (宮城県)
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K15157
[Presentation] Efflux transport of epilepsy-related compounds at the blood-brain barrier.2017
- Author(s)
  Shin-ichi Akanuma, Yoshiyuki Kubo, Ken-ichi Hosoya
- Organizer
  APSTJ Global Educational Seminar 2017 - 2nd
- Invited
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] 中枢神経系疾患治療薬とin vitro血液脳関門ニコチン輸送との相互作用2017
- Author(s)
  赤沼　伸乙、山﨑　雄平、久保　義行、細谷　健一
- Organizer
  日本薬物動態学会　第32回年会
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 脳内tyramineクリアランスへの血液脳脊髄液関門排出輸送機構の関与2017
- Author(s)
  山﨑雄平、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬学会第137年会 (仙台)
- Place of Presentation
  仙台市 (宮城県)
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] 網膜色素上皮細胞におけるchloroquineのlysosomal trappingと細胞障害作用2017
- Author(s)
  牧野　令奈、赤沼　伸乙、久保　義行、細谷　健一
- Organizer
  日本薬学会北陸支部　第129回例会
- Data Source
  KAKENHI-PROJECT-16K15157
[Presentation] 内側血液網膜関門におけるcyanocobalamin輸送機構の解明2017
- Author(s)
  木下由梨、野上暁生、阿部肇、井上将彦、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬学会第137年会 (仙台)
- Place of Presentation
  仙台市 (宮城県)
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 外側血液網膜関門riboflavin輸送機構における輸送担体の関与2017
- Author(s)
  三木智史、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市 (宮城県)
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 網膜色素上皮細胞におけるchloroquineのlysosomal trappingと細胞障害作用2017
- Author(s)
  牧野　令奈、赤沼　伸乙、久保　義行、細谷　健一
- Organizer
  日本薬学会北陸支部　第129回例会
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 血液脳関門nicotine輸送と神経作用薬の相互作用2017
- Author(s)
  細谷　健一、手賀　悠真、赤沼　伸乙、久保　義行
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] Transporter-mediated histamine elimination from cerebrospinal fluid: involvement of PMAT at the blood-cerebrospinal fluid barrier.2016
- Author(s)
  Takuya Usui, Shin-ichi Akanuma, Yoshiyuki Kubo, Ken-ichi Hosoya
- Organizer
  2016 China-Japan-Korea Joint Symposium, 20th Anniversary of Oriental Pharmaceutical Science
- Place of Presentation
  Seoul, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 血液網膜関門を介したcyanocobalamin輸送機構の解明2016
- Author(s)
  木下由梨、野上暁生、阿部肇、井上将彦、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬学会北陸支部　第128回例会
- Place of Presentation
  金沢市 (石川県)
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 眼組織のトランスポーター2016
- Author(s)
  細谷健一
- Organizer
  第36回比較眼科学会年次大会
- Place of Presentation
  東京都
- Year and Date
  2016-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 脳からのスペルミン除去への血液脳脊髄液関門担体介在型輸送の関与2016
- Author(s)
  赤沼伸乙、島田浩和、久保義行、細谷健一
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  松本市 (長野県)
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] 血液網膜関門を介した網膜からのポリアミン排出輸送機構の解明2016
- Author(s)
  久保義行、三浦宏明、冨瀬彩加、赤沼伸乙、細谷健一
- Organizer
  日本脂質栄養学会
- Place of Presentation
  秋田市 (秋田県)
- Year and Date
  2016-09-16
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 血液脳脊髄液関門を介したspermine排出輸送特性2016
- Author(s)
  島田浩和, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 血液網膜関門verapamil輸送におけるlysosomal trappingの関与2016
- Author(s)
  細谷健一、中沢亜弓、赤沼伸乙、久保義行
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  松本市 (長野県)
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 内側血液網膜関門を介した網膜からのputrescine排出輸送機構の解明2016
- Author(s)
  三浦宏明, 冨瀬彩加, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬学会第136年会（横浜）
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] Microdialysis for evaluating the efflux transport of drugs across the blood-retinal barrier.2016
- Author(s)
  Ken-ichi Hosoya
- Organizer
  8th International Symposium on Microdialysis
- Place of Presentation
  Uppsala, Sweden
- Year and Date
  2016-05-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] ラット血液脳関門プロスタグランジン類排出輸送と変動メカニズム2016
- Author(s)
  赤沼伸乙、久保義行、細谷健一
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  名古屋市 (愛知県)
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] 蛍光基質を用いた肝臓における有機アニオン輸送体organic anion-transporting polypeptide (Oatp) 1a4 の機能解析2016
- Author(s)
  木田凜太郎、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬学会北陸支部　第128回例会
- Place of Presentation
  金沢市 (石川県)
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] Histamine elimination from the cerebrospinal fluid: involvement of plasma membrane monoamine transporter at choroid plexus epithelial cells.2016
- Author(s)
  Takuya Usui, Shin-ichi Akanuma, Yoshiyuki Kubo, Ken-ichi Hosoya
- Organizer
  The First International Symposium on Toyama-Asia-Africa Pharmaceutical Network
- Place of Presentation
  Toyama, Japan
- Year and Date
  2016-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 脳関門を介した脳内tyramine消失機構の解明2016
- Author(s)
  山﨑雄平、赤沼伸乙、久保義行、細谷健一
- Organizer
  日本薬学会北陸支部　第128回例会
- Place of Presentation
  金沢市 (石川県)
- Data Source
  KAKENHI-PROJECT-16K08365
[Presentation] 血液脳脊髄液関門を介した脳からのヒスタミン排出輸送：形質膜モノアミントランスポーター (PMAT) の役割2016
- Author(s)
  臼井拓也、中沢亜弓、赤沼伸乙、久保義行、細谷健一
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  名古屋市 (愛知県)
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] Functional expression of nicotine influx transporter driven by an outward H+ gradient in rat blood-brain barrier and liver.2016
- Author(s)
  Yuma Tega, Shin-ichi Akanuma, Yoshiyuki Kubo, Ken-ichi Hosoya
- Organizer
  The First International Symposium on Toyama-Asia-Africa Pharmaceutical Network
- Place of Presentation
  Toyama, Japan
- Year and Date
  2016-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 血液網膜関門におけるSLC52A/RFVTを介したriboflavin輸送2016
- Author(s)
  久保義行、八幡静香、三木智史、赤沼伸乙、細谷健一
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  松本市 (長野県)
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 血液網膜関門を介したverapamil輸送におけるlysosomal trappingの関与2016
- Author(s)
  中沢　亜弓，赤沼　伸乙，久保　義行，細谷　健一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] The role of blood-retinal barrier transporters in retinal drug delivery2016
- Author(s)
  Ken-ichi Hosoya, Shin-ichi Akanuma, Yoshiyuki Kubo
- Organizer
  XXII Biennial Meeting of the International Society for Eye Research
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2016-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] Implications of the carrier-mediated transport of nicotine in lung and other tissues.2016
- Author(s)
  Ken-ichi Hosoya
- Organizer
  Workshop on Drug Transporters in the Lungs, Trinity College Dublin
- Place of Presentation
  Dublin, Ireland
- Year and Date
  2016-09-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05110
[Presentation] 内側血液網膜関門における担体介在型putresine輸送機構の解明2016
- Author(s)
  久保義行、三浦宏明、冨瀬彩加、赤沼伸乙、細谷健一
- Organizer
  日本薬学会第31年会
- Place of Presentation
  岐阜市 (岐阜県)
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 内側および外側血液網膜関門におけるMPP+排出輸送の解明2015
- Author(s)
  久保　義行，山本　正和，赤沼　伸乙，細谷　健一
- Organizer
  日本薬剤学会　第30年会
- Place of Presentation
  長崎市
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 網膜へのriboflavin供給に対する血液網膜関門輸送機構の関与2015
- Author(s)
  八幡静香，赤沼伸乙，久保義行，細谷健一
- Organizer
  日本薬学会北陸支部第１２７回例会
- Place of Presentation
  富山
- Year and Date
  2015-11-15
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 眼組織とトランスポーター2015
- Author(s)
  細谷　健一
- Organizer
  第32回比較眼科学会基礎部会研究会
- Place of Presentation
  名古屋市
- Year and Date
  2015-12-19
- Invited
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液網膜関門riboflavin輸送におけるriboflavin transporters (RFVTs) の関与2015
- Author(s)
  八幡静香，赤沼伸乙，久保義行, 細谷健一
- Organizer
  日本薬学会第136年会（横浜）
- Place of Presentation
  横浜
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] Verapamil網膜関門透過に対するlysosomal trappingの寄与2015
- Author(s)
  中沢　亜弓，赤沼　伸乙，久保　義行，細谷　健一
- Organizer
  日本薬学会北陸支部　第127回例会
- Place of Presentation
  富山市
- Year and Date
  2015-11-15
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液網膜関門を介したカチオン性化合物排出輸送におけるPMAT (SLC29A4) の関与2015
- Author(s)
  久保　義行，山本　正和，赤沼　伸乙，細谷　健一
- Organizer
  フォーラム富山「創薬」　第41回研究会
- Place of Presentation
  富山市
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 内側血液網膜関門を介した網膜から循環血液へのプトレシン輸送における輸送担体の関与2015
- Author(s)
  三浦宏明, 冨瀬彩加, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬物動態学会第３０年会（東京）
- Place of Presentation
  東京
- Year and Date
  2015-11-13
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 内側血液網膜関門を介したニコチン輸送におけるH+/有機カチオン対向輸送体の関与2015
- Author(s)
  手賀悠真，譲原千広，赤沼伸乙，久保義行，細谷健一
- Organizer
  フォーラム富山「創薬」第４１回研究会
- Place of Presentation
  富山
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 血液網膜関門を介した1-Methyl-4-phenyl-pyridinium (MPP+) 排出輸送におけるPMAT (SLC29A4) の関与2015
- Author(s)
  ○久保義行, 山本正和, 赤沼伸乙, 細谷健一
- Organizer
  日本薬学会第135年
- Place of Presentation
  神戸
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 脳関門を介した脳からのspermine消失機構の解明2015
- Author(s)
  島田浩和，赤沼伸乙，久保義行，細谷健一
- Organizer
  日本薬学会北陸支部第１２７回例会
- Place of Presentation
  富山
- Year and Date
  2015-11-15
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 血液網膜関門を介したL-ornithine輸送におけるCAT1 (SLC7A1)の関与2015
- Author(s)
  久保　義行，小畑　晶子，赤沼　伸乙，細谷　健一
- Organizer
  第10回トランスポーター研究会年会
- Place of Presentation
  東京都
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液脳脊髄液関門を介したヒスタミン排出輸送におけるPMATの関与2015
- Author(s)
  臼井拓也，久保義行，赤沼伸乙，細谷健一
- Organizer
  フォーラム富山「創薬」第４１回研究会
- Place of Presentation
  富山
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] Evaluation of carrier-mediated influx and efflux transport of pravastatin across the blood-retinal barrier in rats2015
- Author(s)
  Shinobu Fujii, Chikako Setoguchi, Kouichi Kawazu, Ken-ichi Hosoya
- Organizer
  20th North American ISSX Meeting
- Place of Presentation
  Orlando (Florida, USA)
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] Nicotine生体膜輸送におけるH+/有機カチオン交換輸送体の関与2015
- Author(s)
  手賀悠真，譲原千広，赤沼伸乙，久保義行，細谷健一
- Organizer
  第３７回生体膜と薬物相互作用シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] Nicotine生体膜輸送におけるH+/有機カチオン交換輸送体の関与2015
- Author(s)
  手賀　悠真，譲原　千広，赤沼　伸乙，久保　義行，細谷　健一
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本市
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液網膜関門におけるnicotine輸送機構の解明2015
- Author(s)
  譲原千広，手賀悠真，赤沼伸乙，久保義行，細谷健一
- Organizer
  日本薬学会北陸支部第１２７回例会
- Place of Presentation
  富山
- Year and Date
  2015-11-15
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 血液網膜関門におけるL-ornithine輸送へのCAT1（SLC7A1）の関与2015
- Author(s)
  久保　義行，小畑　晶子，赤沼　伸乙，細谷　健一
- Organizer
  日本薬物動態学会　第30回年会
- Place of Presentation
  東京都
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] In vitro血液網膜関門モデルにおける1-methyl-4-phenylpyridinium輸送解析2014
- Author(s)
  山本正和，赤沼伸乙，久保義行, 細谷健一
- Organizer
  日本薬学会北陸支部第126回例会
- Place of Presentation
  金沢
- Year and Date
  2014-11-16
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液網膜関門トランスポーターと網膜への薬物送達2014
- Author(s)
  細谷健一
- Organizer
  第3回富山・バーゼル医薬品研究開発シンポジウム
- Place of Presentation
  富山
- Year and Date
  2014-08-12
- Invited
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] Role of the blood-retinal barrier in retinal drug delivery.2014
- Author(s)
  Hosoya K.
- Organizer
  Strategies for drug development using natural products
- Place of Presentation
  Seoul, Korea
- Year and Date
  2014-10-06
- Invited
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] In vivoラット血液網膜関門を介した1-methyl-4-phenylpyridinium輸送特性2014
- Author(s)
  久保義行, 松永健甫, 赤沼伸乙, 細谷健一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] The blood-to-retina transport of clonidine at the inner blood-retinal barrier2014
- Author(s)
  ○Kubo Y, Tsuchiyama A, Shimizu Y, Akanuma S, Hosoya K
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco, U.S.A.
- Year and Date
  2014-10-22
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 血液網膜関門におけるカチオン性薬物輸送機構2014
- Author(s)
  ○久保義行, 赤沼伸乙, 細谷健一
- Organizer
  第36回生体膜と薬物相互作用シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-26460193
[Presentation] 内側血液網膜関門を介したL-carnosine前駆物質の網膜供給機構解明2014
- Author(s)
  臼井拓也, 久保義行, 赤沼伸乙, 細谷健一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 網膜毛細血管内皮細胞へのカチオン性薬物取り込みに対するlysosomal trappingの影響2014
- Author(s)
  瀬古成美，久保義行，赤沼伸乙, 細谷健一
- Organizer
  日本薬学会北陸支部第126回例会
- Place of Presentation
  金沢
- Year and Date
  2014-11-16
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 内側血液網膜関門propranolol輸送における新規輸送担体の関与2013
- Author(s)
  清水芳美, 久保義行, 草川友輔, 赤沼伸乙, 細谷健一
- Organizer
  日本薬学会北陸支部第125回例会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] Microdialysis法を用いた血液網膜関門からの有機カチオン排出輸送の解析2013
- Author(s)
  松永健甫, 赤沼伸乙, 久保義行, 立川正憲, 細谷健一
- Organizer
  日本薬学会北陸支部第125回例会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] Involvement of a carrier-mediated transport process in the influx transport of propranolol across the inner blood-retinal barrier2013
- Author(s)
  Kubo Y., Shimizu Y., Kusagawa Y., Akanuma S., Hosoya K.
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液脳関門を介したニコチン輸送におけるピリラミン感受性新規輸送担体の関与2013
- Author(s)
  細谷健一, 手賀悠真, 赤沼伸乙, 久保義行
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 内側血液網膜関門におけるclonidine輸送機構解析2013
- Author(s)
  土山愛, 清水芳美, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬学会北陸支部第125回例会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液網膜関門を介したpropranolol輸送機構2013
- Author(s)
  久保義行, 清水芳美, 草川友輔, 赤沼伸乙, 細谷健一
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] Supply of L-carnosine to the retina potentially involves carrier-mediated transport of β-alanine and L-histidine across the inner blood-retinal barrier.2013
- Author(s)
  Usui T., Kubo Y., Akanuma S., Hosoya K.
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 内側血液網膜関門におけるspermine輸送特性2013
- Author(s)
  冨瀬彩加, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬学会北陸支部第125回例会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 内側血液網膜関門におけるpropranolol輸送機構解明2013
- Author(s)
  清水芳美, 久保義行, 草川友輔, 赤沼伸乙, 細谷健一
- Organizer
  第21回クリニカルファーマシーシンポジウム
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液網膜関門トランスポーターと薬物輸送2013
- Author(s)
  細谷健一
- Organizer
  第５７回日本薬学会関東支部大会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 内側血液網膜関門におけるL-ornithine輸送機構解析2013
- Author(s)
  小畑晶子, 赤沼伸乙, 久保義行, 細谷健一
- Organizer
  日本薬学会北陸支部第125回例会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 脳脊髄液からのL-glutamate排出輸送解析2011
- Author(s)
  櫻井達彦、赤沼伸乙、立川正憲、久保義行、細谷健一
- Organizer
  日本薬学会北陸支部第123回例会
- Place of Presentation
  金沢市
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Role of organic anion transporter 3 at the blood-cerebrospinal fluid barrier in the elimination of prostaglandin E_2 produced in the brain2011
- Author(s)
  Akanuma S., Ozeki G., Tachikawa M., Hosoya K.
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島県広島市
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Role of organic anion transporter 3 at the blood-cerebrospinal fluid barrier in the elimination of prostaglandin E_2 produced in the brain2011
- Author(s)
  Shin-ichi Akanuma, Gou Ozeki, Masanori Tachikawa, Ken-ichi Hosoya
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島市
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] 脳脊髄液からのL-glutamate排出輸送解析2011
- Author(s)
  櫻井達彦、赤沼伸乙、立川正憲、久保義行、細谷健一
- Organizer
  日本薬学会北陸支部第123回例会
- Place of Presentation
  石川県金沢市
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Effect of lipophilicity and carrier-mediated transport on blood-retinal barrier permeability.2010
- Author(s)
  Hosoya K., et al.
- Organizer
  FIP pharmaceutical sciences 2010 world congress/AAPS annual meeting and exposition.
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] 脳を守るトランスポーターと尿毒症物質2010
- Author(s)
  細谷健一
- Organizer
  第40回日本腎臓学会東部学術大会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] MRP4機能阻害薬物投与によるマウス脳から血液脳関門を介したPGE2排出の阻害2010
- Author(s)
  赤沼伸乙、伊藤慎悟、立川正憲、大槻純男、細谷健一、寺崎哲也
- Organizer
  日本薬学会第130年会(会期平成22年3月28日-30日)
- Place of Presentation
  岡山桃太郎アリーナ
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] MRP4機能阻害薬物投与によるマウス脳から血液脳関門を介したPGE_2排出の阻害2010
- Author(s)
  赤沼伸乙、伊藤慎悟、立川正憲、大槻純男、細谷健一、寺崎哲也
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山県岡山市
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] 脳を守るトランスポーターと尿毒症物質2010
- Author(s)
  細谷健一
- Organizer
  第40回日本腎臓学会東部学術大会
- Place of Presentation
  栃木県宇都宮市
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Effect of lipophilicity and carrier-mediated transport on blood-retinal barrier permeability2010
- Author(s)
  Hosoya K., Yamamoto A., Akanuma S., Tachikawa M.
- Organizer
  FIP pharmaceutical sciences 2010 world congress/AAPS annual meeting and exposition.
- Place of Presentation
  Neu Orileans, USA
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Organic anion transporter3を介したprostaglandin E_2輸送機能解析2010
- Author(s)
  樋口貴則、赤沼伸乙、立川正憲、細谷健一
- Organizer
  日本薬学会北陸支部平成22年度第1回総会及び第122回例会
- Place of Presentation
  石川県金沢市
- Year and Date
  2010-11-21
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] 血液脳脊髄液関門を介したprostaglandin E_2排出におけるorganic anion transporter(OAT) 3の関与2010
- Author(s)
  小関剛、赤沼伸乙、立川正憲、細谷健一
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山県富山市
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Involvement of Prostaglandin Transporter in Prostaglandin D2 Transport at the Blood-cerebrospinal Fluid Barrier2009
- Author(s)
  Kazuhiro Tsuji, Masanori Tachikawa, Shin-ichi Akanuma, Kazuyuki Hayashi, Akio Nishiura, Ken-ichi Hosoya
- Organizer
  2009 AAPS Annual Meeting and Exposition
- Place of Presentation
  Los Angeles Convention Center
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Inhibition of prostaglandin E2 elimination via blood-brain barrier by cephalosporins interacting with multidrug resistance-associated protein 42009
- Author(s)
  Shin-ichi Akanuma, Shingo Ito, Sumio Ohtsuki, Ken-ichi Hosoya, Tetsuya Terasaki
- Organizer
  日本薬物動態学会第24回年会(会期平成21年11月27日-29日)
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Inner Blood-Retinal Barrier Transport and Regulation of Amino Acids2009
- Author(s)
  Hosoya K.
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪大学コンベンションセンター
- Data Source
  KAKENHI-PROJECT-20659022
[Presentation] 脳内プロスタグランジンE合成酵素発現及び脳室からのプロスタグランジンE_2排出輸送の解析2009
- Author(s)
  小関剛、辻和宏、赤沼伸乙、立川正憲、細谷健一
- Organizer
  日本薬学会北陸支部第121回例会
- Place of Presentation
  富山大学杉谷(医薬系)キャンパス
- Year and Date
  2009-12-06
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Inhibition of prostaglandin E_2 elimination via blood-brain barrier by cephalosporins interacting with multidrug resistance-associated protein 42009
- Author(s)
  Akanuma S., Ito S., Ohtsuki S., Hosoya K., Terasaki T.
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都府京都市
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] 脳内プロスタグランジンE合成酵素発現及び脳室からのプロスタグランジンE_2排出輸送の解析2009
- Author(s)
  小関剛、辻和宏、赤沼伸乙、立川正憲、細谷健一
- Organizer
  日本薬学会北陸支部第121回例会
- Place of Presentation
  富山県富山市
- Year and Date
  2009-12-06
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Localization and transport function of prostaglandin transporter (PGT) in the brain2009
- Author(s)
 Kazuhiro Tsuji, Masanori Tachikawa, Shin-ichi Akanuma, Kazuyuki Hayashi, Akio Nishiura, Ken-ichi Hosoya
- Organizer
 8^<th> Cerebral Vascular Biology 2009
- Place of Presentation
 仙台エクセルホテル東急
- Data Source
 KAKENHI-PROJECT-21390042
[Presentation] Involvement of Prostaglandin Transporter in Prostaglandin D_2 Transport at the Blood-cerebrospinal Fluid Barrier2009
- Author(s)
  Tsuji K., Tachikawa M., Akanuma S., Hayashi K., Nishiura A., Hosoya K.
- Organizer
  2009 AAPS Annual Meeting and Exposition
- Place of Presentation
  Los Angeles, USA
- Data Source
  KAKENHI-PROJECT-21390042
[Presentation] Localization and transport function of prostaglandin transporter(PGT) in the brain2009
- Author(s)
 Tsuji K., Tachikawa M., Akanuma S., Hayashi K., Nishiura A., Hosoya K.
- Organizer
 8^<th> Cerebral Vascular Biology 2009
- Place of Presentation
 宮城県仙台市
- Data Source
 KAKENHI-PROJECT-21390042
[Presentation] 血液網膜関門を介したp-aminohippuric acid排出輸送におけるOAT3の関与2007
- Author(s)
  細谷健一
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] Inner blood-retinal barrier transport and drug delivery to the retina.2007
- Author(s)
  K. Hosoya
- Organizer
  International Conference of the Korean Society of Pharmaceutical Sciences and Technology
- Place of Presentation
  Seoul
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] Involvement of transporters in the retina-to-blood efflux transport of organic anions at the inner blood-retinal barrier.2007
- Author(s)
  K. Hosoya
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] Involvement of transporters in the retina-to-blood efflux transport of organic anions at the inner blood-retinal barrier2007
- Author(s)
  K, Hosoya, A. Makihara, Y, Ohshima, K, Katayama, M, Tomi, M, Tachikawa
- Organizer
  29th Symposium on Biomembrane-Drug Interaction
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] The role of scavenger receptor class B type I(SR-BI) in vitamin E uptake at the inner blood-retinal barrier2007
- Author(s)
  S, Okayasu, M, Tachikawa, K, Hosoya
- Organizer
  AAPS annual meeting and exposition
- Place of Presentation
  San Diego
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] Inner blood-retinal barrier transport and drug delivery to the retina2007
- Author(s)
  K, Hosoya
- Organizer
  International Conference of the Korean Society of Pharmaceutical Sciences and Technology
- Place of Presentation
  Seoul
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] Gene expression of ATP-binding cassette transporter A and C subfamilies at the mouse inner blood-retinal barrier2007
- Author(s)
  M, Tachikawa, M, Toki, M, Tomi, K, Hosoya
- Organizer
  4th World Conference on Drug Absorption, Transport and Delivery
- Place of Presentation
  Kanazawa
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] The role of reduced folate transporter1(RTF1) in methyletrahydrofolate transport at the inner blood-retinal barrier2007
- Author(s)
  K, Fujita, M, Tachikawa, K, Hosoya
- Organizer
  AAPS annual meeting and exposition
- Place of Presentation
  San Diego
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] Inner blood-retinal barrier transport and drug delivery to the retina2007
- Author(s)
  K.Hosoya
- Organizer
  International Conference of the Korean Society of Pharmaceutical Sciences and Technology
- Place of Presentation
  Seoul
- Data Source
  KAKENHI-PROJECT-19659035
[Presentation] Inner blood-retinal barrier transport: implications for retinal drug delivery2006
- Author(s)
  K. Hosoya
- Organizer
  AAPS annual meeting and exposition
- Place of Presentation
  San Antonio
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] Quantitative determination of ABCA and ABCC transporter gene expression levels at the mouse inner blood-retinal barrier2006
- Author(s)
  K. Hosoya
- Organizer
  AAPS annual meeting and exposition
- Place of Presentation
  San Antonio
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390048
[Presentation] タウリンの体内動態とタウリントランスポーターの役割
- Author(s)
  細谷健一，赤沼伸乙，久保義行
- Organizer
  第1回国際タウリン研究会日本部会
- Place of Presentation
  神戸
- Year and Date
  2015-02-21 – 2015-02-22
- Invited
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 内側血液網膜関門を介したL-carnosine前駆物質の網膜供給機構解明
- Author(s)
  細谷健一，手賀悠真, 赤沼伸乙, 久保義行
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  大宮
- Year and Date
  2014-05-27 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 内側血液網膜関門を介したspermine輸送解析
- Author(s)
  冨瀬彩加，久保義行，赤沼伸乙，細谷健一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 内側血液網膜関門を介したclonidine輸送機構解析
- Author(s)
  土山愛，清水芳美，赤沼伸乙，久保義行，細谷健一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] The blood-to-retina transport of clonidine at the inner blood-retinal barrier.
- Author(s)
  Kubo Y., Tsuchiyama A., Shimizu Y., Akanuma S., Hosoya K.
- Organizer
  The 19th north american ISSX and 29th JSSX meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液脳脊髄液関門histamine排出輸送におけるPMATの関与
- Author(s)
  臼井拓也，久保義行，赤沼伸乙，細谷健一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 内側血液網膜関門nicotine輸送へのH+/有機カチオン対向輸送体の関与
- Author(s)
  手賀悠真，讓原千広，久保義行，赤沼伸乙，細谷健一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液網膜関門における1-methyl-4-phenylpyridinium輸送の機能特性
- Author(s)
  久保義行，松永健甫，赤沼伸乙, 細谷健一
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  大宮
- Year and Date
  2014-05-27 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液網膜関門を介したL-ornithine輸送におけるCAT1の関与
- Author(s)
  小畑晶子，赤沼伸乙，久保義行，細谷健一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] Nicotine transport in the rat blood-brain barrier and liver.
- Author(s)
  Tega Y., Akanuma S., Kubo Y., Hosoya K.
- Organizer
  The 19th north american ISSX and 29th JSSX meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] Roles of the blood-retinal barrier in retinal drug delivery.
- Author(s)
  Hosoya K.
- Organizer
  17th international symposiun signal transduction at the blood-brain and blood-retinal barriers
- Place of Presentation
  Dublin, Ireland
- Year and Date
  2014-09-11 – 2014-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液網膜関門を介した1-methyl-4-phenyl-pyridinium (MPP+)排出輸送におけるPMAT (SLC29A4) の関与
- Author(s)
  久保義行，山本正和，赤沼伸乙，細谷健一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 血液網膜関門におけるカチオン性薬物輸送機構
- Author(s)
  久保義行，赤沼伸乙，細谷健一
- Organizer
  第36回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2014-11-20 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] 網膜毛細血管内皮細胞lysosomal trappingがカチオン性薬物輸送に与える影響
- Author(s)
  瀬古成美，赤沼伸乙，久保義行，細谷健一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] Evaluation of P-glycoprotein and carrier-mediated influx transporters on blood-retinal, -aqueous humor, and -brain barrier permeabilities using the mdr1a knockout rats.
- Author(s)
  Fujii S., Setoguchi C., Kawazu K., Hosoya K.
- Organizer
  The 19th north american ISSX and 29th JSSX meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25293036
[Presentation] Involvement of PMAT in histamine efflux from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier.
- Author(s)
  Usui T., Kubo Y., Akanuma S., Hosoya K.
- Organizer
  The 19th north american ISSX and 29th JSSX meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25293036
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1. AKANUMA Shin-ichi (30467089)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
2. KUBO Yoshiyuki (20377427)

# of Collaborated Projects: 8 results

# of Collaborated Products: 126 results
3. TERASAKI Tetsuya (60155463)

# of Collaborated Projects: 8 results

# of Collaborated Products: 9 results
4. TACHIKAWA Masanori (00401810)

# of Collaborated Projects: 7 results

# of Collaborated Products: 37 results
5. TOMI Masatoshi (30334717)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. SAKAI Hideki (60242509)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MATSUYA Yuji (50255858)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OBINATA Masuo (10099971)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TAKANAGA Hitomi (20284523)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. OHTSUKI Sumio (60323036)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KATAYAMA Kazunori (70126514)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MORI Shinobu

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. TAKASHIMA Tadayuki (80469907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KIKUCHI Akihiko (40266820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ABE Takaaki (80292209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. HATANAKA Yasumaru (30111181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MIZUGUCHI Mineyuki (30332662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Nishi Tsuyoshi (60403002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 大熊芳明 (70192515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 友廣岳則 (70357581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 石川智久 (60193281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 大石雄基 (00778467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
23. 田渕圭章 (20322109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 泉尾直孝 (50722261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 豊岡尚樹 (10217565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. FUKUSHIMA Kiyomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KAWAZU Kouichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. ABE Hajime

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
29. ANDO Tsugunobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 赤沼伸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 172 results

Hosoya Kenichi 細谷 健一

HOSOYA Ken-ichi 細谷 健一

細谷 建一 ホソヤ ケンイチ

Research Projects

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脳クレアチン供給を実現するモノカルボン酸輸送体認識型プロドラッグ開発とその有用性Principal Investigator

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Role of MCT9 and 14 as mechanisms of transporting cationic drugs/compounds at the blood-retinal barrier.Principal Investigator

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The foundation of developing drugs for retinal diseases by pharmaceutical drug-repositioning screening based on the distribution manner via the blood-retinal barrierPrincipal Investigator

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Evaluation of Cx43 proteins for PGE2 release from retinal pigment epithelial cells for understanding the pathological role in age-related macular degeneration.Principal Investigator

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Evaluation of cationic drug transport system at the blood-retinal barrier to deliver the drugs to the retinaPrincipal Investigator

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Molecular mechanisms of prostaglandin elimination across brain barriers and its application to neural inflammatory diseasesPrincipal Investigator

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Molecular identification and physiological role of brain-type prostaglandin transporterPrincipal Investigator

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Project Period (FY)

Research Category

Research Field

Research Institution

血液網膜関門排出輸送に基づくアミロイドβ排出戦略Principal Investigator

Principal Investigator

Hosoya Kenichi 細谷健一

HOSOYA Ken-ichi 細谷健一

細谷建一ホソヤケンイチ