Horiguchi Taigo 堀口大吾

… Alternative Names

堀口大吾ホリグチタイゴ

HORIGUCHI Taigo 堀口大吾

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Researcher Number	70304532
Other IDs
Affiliation (Current)	2025: 徳島大学, 大学院医歯薬学研究部(歯学域), 助教
Affiliation (based on the past Project Information) *help	2019 – 2025: 徳島大学, 大学院医歯薬学研究部(歯学域), 助教 2016 – 2017: 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 2004 – 2005: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助手 2001 – 2002: 徳島大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Functional basic dentistry Except Principal Investigator Functional basic dentistry / Basic Section 57060:Surgical dentistry-related / Basic Section 57010:Oral biological science-related / Basic Section 57020:Oral pathobiological science-related / Pathobiological dentistry/Dental radiology
Keywords	Principal Investigator デンチンシアロホスホ蛋白質 / デンチンシアロホス蛋白質 / 石灰化 / 象牙質 Except Principal Investigator ミトコンドリア / アデニル酸キナーゼ２ / AK2 / 細網異形成症 / 重症複合型免疫不全症 / ゴーシェ病 … More / ATP / FRET / 分子標的治療薬 / 口腔がん / 口腔癌 / エピトランスクリプトーム / RNA修飾 / GCase / 糖脂質分解酵素 / 成熟停止 / レチノイン酸 / genome / transcriptome / ERストレス / ミトコンドリア機能 / ATRA / 好中球分化 / ゲノム解析 / microarray / 分化誘導 / 好中球 / HL60 / adenylate kinase 2 / 構造活性相関 / 酵素活性 / 常染色体劣性遺伝 / ATP合成 / 誘導型発現ベクター / テトラサイクリン / FoxP3遺伝子 / 制御性T細胞 / 組織特異的遺伝子発現 / 細胞分化 / 遺伝子変異 / 血球細胞分化制御 / エネルギー代謝 / 幹細胞 / 細胞内局在 / ハイスループット酵素活性測定系 / SiRNA / GCase結合タンパク質 / in cell 酵素活性解析 / SiRNA スクリーニング / GCase活性調節タンパク質 / データマイニング / エクソーム解析 / intact cell GCase assay / モディファイヤー検索 / exome解析 / 口腔粘膜線維芽細胞 / Adenylate Kinase / ミトコンドリア膜間 / アイソザイム / アデニンヌクレオチド / アデニル酸キナーゼ Less

脱ユビキチン化酵素OTUB1含有エクソソームの免疫チェックポイント機能への影響Principal Investigator
- Principal Investigator
  
  堀口大吾
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  The University of Tokushima
RNA修飾による糖脂質分解酵素活性制御機構の解明とゴーシェ病克服への挑戦
- Principal Investigator
  
  三好圭子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  The University of Tokushima
Investigation of novel oral cancer-specific molecular targets based on genetic diversity
- Principal Investigator
  
  工藤保誠
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  The University of Tokushima
Identification of signal targets in neutrophil differentiation
- Principal Investigator
  
  NOMA TAKAFUMI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Hiroshima Jogakuin University
  The University of Tokushima
Characterization of Gaucher disease by new gene mutation using patient-derived oral mucosa fibroblasts
- Principal Investigator
  
  MIYOSHI Keiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
Study on elucidation of the pathophysiology of rare intractable diseases (reticular dysgenesis) with severe combined immunodeficiency and development of therapeutic methods
- Principal Investigator
  
  NOMA Takafumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  The University of Tokushima
Development of sensors for monitoring intracellular ATP and GTP.
- Principal Investigator
  
  NOMA Takafumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
象牙質に特異的な非コラーゲン性蛋白質の機能に関する研究Principal Investigator
- Principal Investigator
  
  堀口大吾
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima

All 2023 2022 2017 2015

All Journal Article Presentation

[Journal Article] Involvement of the OTUB1‐YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma2023
- Author(s)
  Jin Shengjian、Tsunematsu Takaaki、Horiguchi Taigo、Mouri Yasuhiro、Shao Wenhua、Miyoshi Keiko、Hagita Hiroko、Sarubo Motoharu、Fujiwara Natsumi、Qi Guangying、Ishimaru Naozumi、Kudo Yasusei
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 24 Pages: 22156-22169
- DOI
  10.1002/cam4.6735
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18361, KAKENHI-PROJECT-23K15977, KAKENHI-PROJECT-22K10342, KAKENHI-PROJECT-22K19630, KAKENHI-PROJECT-23H00438, KAKENHI-PROJECT-23K24546, KAKENHI-PROJECT-23K24547
[Journal Article] The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma2022
- Author(s)
  Jin Shengjian、Kudo Yasusei、Horiguchi Taigo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 1 Pages: 552-552
- DOI
  10.3390/ijms24010552
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24546
[Journal Article] Gene signature of human oral mucosa fibroblasts: comparison with dermal fibroblasts and induced pluripotent stem cells.2015
- Author(s)
  Miyoshi K, Horiguchi T, Tanimura A, Hagita H, Noma T.
- Journal Title
  
  Biomed Res Int.
  
  Volume: 2015 Pages: 1-19
- DOI
  10.1155/2015/121575
- NAID
  120006783219
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11041
[Presentation] 頭頸部扁平上皮癌 (HNSCC) の進行における脱ユビキチン化酵素 OTUB1 の役割2023
- Author(s)
  Jin Shengjian, 常松貴明, 堀口大吾, 毛利安宏, 卲文華, 三好圭子, 水澤典子, 萩田浩子, 猿棒元陽, 吉田佳世,吉田賀弥, 藤原奈津美, 尾崎和美, 石丸直澄
- Organizer
  第 82 回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24546
[Presentation] 脱ユビキチン化酵素OTUB1 の頭頸部扁平上皮癌の進展における役割2022
- Author(s)
  金晟劍, 常松貴明, 堀口大吾，石丸直澄, 工藤保誠
- Organizer
  第64 回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24546
[Presentation] The role of Deubiquitinating enzyme, OTUB1 in head and neck squamous cell carcinoma (HNSCC) progression2022
- Author(s)
  Jin Shengjian，常松貴明，堀口大吾，毛利安宏，邵文華，三好圭子，水澤典子，萩田浩子，吉田佳世，吉田賀弥，藤原奈津美，尾崎和美，石丸直澄，工藤保誠
- Organizer
  第61回四国歯学会例会
- Data Source
  KAKENHI-PROJECT-23K24546
[Presentation] CRISPR/Cas9を用いたAK2の段階的欠損による細胞代謝への影響2017
- Author(s)
  谷村綾子、三好圭子、堀口大吾、藤沢浩一、野間隆文
- Organizer
  第２回日本ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-15K11072
[Presentation] GBA 遺伝子5´側バリアントの発現パターン解析2017
- Author(s)
  三好圭子, 萩田浩子, 谷村綾子, 堀口大吾, 野間隆文
- Organizer
  2017 年度生命科学系学会合同年次大会ConBio 2017 （神戸、兵庫）
- Data Source
  KAKENHI-PROJECT-15K11041
[Presentation] ミトコンドリアがUPR活性をコントロールして免疫細胞分化の方向を決定づける2017
- Author(s)
  谷村綾子、三好圭子、堀口大吾、萩田浩子、藤沢浩一、野間隆文
- Organizer
  第17回日本ミトコンドリア学会
- Data Source
  KAKENHI-PROJECT-15K11072
[Presentation] From Molecular Structure and Mechanisms to Cellular Bioenergetics in Health and Disease2017
- Author(s)
  Tanimura A, Miyoshi K, Horiguchi T, Hagita H, Fujisawa K, Noma T
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11072

1. NOMA Takafumi (40189428)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. MIYOSHI Keiko (20304537)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 毛利安宏 (80464353)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 谷村綾子 (10610199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 萩田浩子 (30512123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 工藤保誠 (50314753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 岡本哲治 (00169153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 宮本洋二 (20200214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 石丸直澄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 常松貴明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Horiguchi Taigo 堀口 大吾

堀口 大吾 ホリグチ タイゴ

HORIGUCHI Taigo 堀口 大吾

Research Projects

Research Products

Co-Researchers

脱ユビキチン化酵素OTUB1含有エクソソームの免疫チェックポイント機能への影響Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RNA修飾による糖脂質分解酵素活性制御機構の解明とゴーシェ病克服への挑戦

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of novel oral cancer-specific molecular targets based on genetic diversity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of signal targets in neutrophil differentiation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of Gaucher disease by new gene mutation using patient-derived oral mucosa fibroblasts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on elucidation of the pathophysiology of rare intractable diseases (reticular dysgenesis) with severe combined immunodeficiency and development of therapeutic methods

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of sensors for monitoring intracellular ATP and GTP.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

象牙質に特異的な非コラーゲン性蛋白質の機能に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Involvement of the OTUB1‐YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gene signature of human oral mucosa fibroblasts: comparison with dermal fibroblasts and induced pluripotent stem cells.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] 頭頸部扁平上皮癌 (HNSCC) の進行における脱ユビキチン化酵素 OTUB1 の役割2023

Author(s)

Organizer

Data Source

[Presentation] 脱ユビキチン化酵素OTUB1 の頭頸部扁平上皮癌の進展における役割2022

Author(s)

Organizer

Data Source

[Presentation] The role of Deubiquitinating enzyme, OTUB1 in head and neck squamous cell carcinoma (HNSCC) progression2022

Author(s)

Horiguchi Taigo 堀口大吾

堀口大吾ホリグチタイゴ

HORIGUCHI Taigo 堀口大吾