Habu Toshiyuki 土生敏行

… Alternative Names

土生敏行ハブトシユキ

HABU Toshiyuki 土生敏行

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Researcher Number	70346071
Other IDs
Affiliation (Current)	2025: 武庫川女子大学, 食物栄養科学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 武庫川女子大学, 食物栄養科学部, 教授 2021: 武庫川女子大学, 食物栄養科学部, 准教授 2020: 武庫川女子大学, 生活環境学部, 准教授 2015 – 2017: 武庫川女子大学, 生活環境学部, 准教授 2011 – 2014: 京都大学, 放射線生物研究センター, 助教 2007: 放射線生物研究センター, 助教 2003 – 2006: 京都大学, 放射線生物研究センター, 助手
Review Section/Research Field	Principal Investigator Cell biology / Tumor biology Except Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach / Complex systems / Cell biology / Epidemiology and preventive medicine / Biological Sciences / Risk sciences of radiation/Chemicals
Keywords	Principal Investigator 血管内皮細胞 / 脂肪滴 / 低酸素環境 / 酸素環境 / 脂質代謝 / オートファジー / モヤモヤ病 / パピローマウイルス / 外的要因ストレス / 遺伝子改変 … More / がん抑制遺伝子 / HPV / SNP / p53 … More Except Principal Investigator Mad2 / p31comet / スピンドルチェックポイント / RNF213 / もやもや病 / DNCI / 有糸分裂期 / 糖尿病 / 小胞体ストレス / 血管閉塞性病変 / R4810K変異 / 脳卒中 / 循環器疾患 / AAA+ / E3 ligase / ウイルス抗体の保有状況 / Mitotic failure / Arterial-Stenosis / RNF213-R4810K / 腸内細菌 / 細胞分裂 / R4810K / Apoptosis / ER stress / シグナル制御 / 感受性遺伝子 / 遺伝疫学 / spindle checkpoint / mitosis / EB1 / Mad1 / ユビキチン化 / 紡錘糸 / 動原体 / 染色体安定性 / 細胞周期 / 医歯薬学 / 衛生学 / 社会医学 / 予防医学 / 分子遺伝疫学 / 紡錘糸阻害剤 / 染色体配分 / オーロラキナーゼ / アポトーシス / 染色体分配 / p53 / DNA損傷 / 染色体 / 放射線 Less

Role of RNF213 as a novel endoplasmic reticulum stress regulator in diabetes mellitus.
- Principal Investigator
  
  小林果
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Mie University
Mechanism and processe of stenoocclusive vascular diseases caused by RNF213 mutation in inflammatory cellular society
- Principal Investigator
  
  Koizumi Akio
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
Analysis of reletionship between RNF213 moyamoya factor and autophagyPrincipal Investigator
- Principal Investigator
  
  Habu Toshiyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Mukogawa Women's University
Molecular pathology of moyamoyta disease and its translational research toward prevention and drug development
- Principal Investigator
  
  KOIZUMI Akio
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Kyoto University
Analysis of p53 72SNP in stress responcePrincipal Investigator
- Principal Investigator
  
  HABU Toshiyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kyoto University
ゲノム安定性を維持するスピンドルチェックポイントの分子機構
- Principal Investigator
  
  松本智裕
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
有糸分裂期の放射線応答
- Principal Investigator
  
  MATSUMOTO Tomohiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyoto University
The signal cascade of the spindle checkpoint
- Principal Investigator
  
  MATSUMOTO Tomohiro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Kyoto University

[Book] Moyamoya Disease: Current Knowledge and Future Perspectives2021
- Author(s)
  Hatasu Kobayashi, Kouji H. Harada, Toshiyuki Habu, Yasuhisa Nakamura, Jiyeong Kim, Akio Koizumi
- Total Pages
  341
- Publisher
  Springer Singapore
- Data Source
  KAKENHI-PLANNED-17H06397
[Journal Article] Suppression of RNF213, a susceptibility gene for moyamoya disease, inhibits endoplasmic reticulum stress through SEL1L upregulation2022
- Author(s)
  Ahmed Sharif、Habu Toshiyuki、Kim Jiyeong、Okuda Hiroko、Oikawa Shinji、Murata Mariko、Koizumi Akio、Kobayashi Hatasu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 609 Pages: 62-68
- DOI
  10.1016/j.bbrc.2022.04.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06397, KAKENHI-PROJECT-22K10487, KAKENHI-PROJECT-21K19640, KAKENHI-PROJECT-19KK0238, KAKENHI-PROJECT-19K10608, KAKENHI-PROJECT-23K24589, KAKENHI-PROJECT-19H03885
[Journal Article] UBC13 is an RNF213-associated E2 ubiquitin-conjugating enzyme, and Lysine 63-linked ubiquitination by the RNF213UBC13 axis is responsible for angiogenic activity.2021
- Author(s)
  Habu T, Harada K
- Journal Title
  
  FASEB Bioadv.
  
  Volume: 3 Issue: 4 Pages: 243-258
- DOI
  10.1096/fba.2019-00092
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06397
[Journal Article] The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress2017
- Author(s)
  Wakida Takeshi、Ikura Masae、Kuriya Kenji、Ito Shinji、Shiroiwa Yoshiharu、Habu Toshiyuki、Kawamoto Takuo、Okumura Katsuzumi、Ikura Tsuyoshi、Furuya Kanji
- Journal Title
  
  eLife
  
  Volume: 6 Pages: 1-26
- DOI
  10.7554/elife.29953
- NAID
  120006370731
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00544, KAKENHI-PROJECT-17K07284, KAKENHI-PUBLICLY-16H01307, KAKENHI-PROJECT-17H01875, KAKENHI-PROJECT-15K07044
[Journal Article] PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.2016
- Author(s)
  Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofield CJ, Dennis JW, Wouters BG, Neel BG.
- Journal Title
  
  Nat Cell Biol
  
  Volume: 18 Issue: 7 Pages: 803-813
- DOI
  10.1038/ncb3376
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460801, KAKENHI-PROJECT-15K07044
[Journal Article] A new horizon of moyamoya disease and associated health risks explored through RNF213.2016
- Author(s)
  Koizumi A, Kobayashi H, Hitomi T, Harada KH, Habu T, Youssefian S.
- Journal Title
  
  Environ Health Prev Med.
  
  Volume: 21(2) Issue: 2 Pages: 55-70
- DOI
  10.1007/s12199-015-0498-7
- NAID
  120005973383
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07044, KAKENHI-PROJECT-15K19243, KAKENHI-PROJECT-25253047, KAKENHI-PROJECT-26460801
[Journal Article] RNF213 rare variants in Slovakian and Czech moyamoya disease patients2016
- Author(s)
  Hatasu Kobayashi, Miroslav Brozman, Kateina Kyselova, DaaViszlayova, Takaaki Morimoto, Martin Roubec, David koloudik, Andrea Petroviova , Dominik Juskani,Jozef Strauss , Marian Halaj, Peter Kurray , Marian Hranai, Koji Harada, Sumiko Inoue ,Toshiyuki Habu, Roman Herzig , Akio Koizumi
- Journal Title
  
  PLOS ONE
  
  Volume: 11 Issue: 10 Pages: e0164759-e0164759
- DOI
  10.1371/journal.pone.0164759
- NAID
  120005853279
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07044, KAKENHI-PROJECT-15K19243
[Journal Article] Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo.2015
- Author(s)
  Kobayashi H, Matsuda Y, Hitomi T, Okuda H, Shioi H, Matsuda T, Imai H, Sone M, Taura D, Harada KH, Habu T, Takagi Y, Miyamoto S, Koizumi A.
- Journal Title
  
  J Am Heart Assoc.
  
  Volume: 30;4(7) Issue: 7
- DOI
  10.1161/jaha.115.002146
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07044, KAKENHI-PROJECT-26460801, KAKENHI-PROJECT-15K19243, KAKENHI-PROJECT-25253047, KAKENHI-PROJECT-24300161
[Journal Article] 1. Pcf1, a large subunit of CAF-1, required for maintenance of checkpoint kinase Cds1 activity2014
- Author(s)
  Kunoh T and Habu T.
- Journal Title
  
  Springer Plus
  
  Volume: 3:30 Issue: 1 Pages: 1-8
- DOI
  10.1186/2193-1801-3-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501267, KAKENHI-PROJECT-25253047
[Journal Article] Pcf1, a large subunit of CAF-1, required for maintenance of checkpoint kinase Cds1 activity2014
- Author(s)
  Kunoh T and Habu T
- Journal Title
  
  Springer Plus
  
  Volume: 3 Pages: 30-30
- Data Source
  KAKENHI-PROJECT-23501267
[Journal Article] The moyamoya disease susceptibility variant RNF213 R4810K (rs112735431)2013
- Author(s)
  Hitomi T, Habu T, Kobayashi H, Okuda H, Harada KH, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 439(4) Issue: 4 Pages: 419-426
- DOI
  10.1016/j.bbrc.2013.08.067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PROJECT-23501267, KAKENHI-PROJECT-23590741, KAKENHI-PROJECT-24390343, KAKENHI-PROJECT-25253047, KAKENHI-PROJECT-25840024, KAKENHI-PROJECT-25893104
[Journal Article] An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast.2013
- Author(s)
  Horikoshi Y, Habu T, Matsumoto T.
- Journal Title
  
  Cell Cycle
  
  Volume: 12:6 Issue: 6 Pages: 961-971
- DOI
  10.4161/cc.23946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501267
[Journal Article] The p31^<comet> inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs2013
- Author(s)
  Habu T and Matsumoto T
- Journal Title
  
  Springer Plus
  
  Volume: 2 Pages: 562-562
- Data Source
  KAKENHI-PROJECT-23501267
[Journal Article] Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients2013
- Author(s)
  Hitomi T, Habu T, Kobayashi H, Okuda H, Harada KH, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 438(1) Pages: 13-19
- Data Source
  KAKENHI-PROJECT-23501267
[Journal Article] p31comet inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs2013
- Author(s)
  Habu T and Matsumoto T.
- Journal Title
  
  Springer Plus
  
  Volume: 2:562 Issue: 1 Pages: 1-15
- DOI
  10.1186/2193-1801-2-562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501267, KAKENHI-PROJECT-25253047
[Journal Article] The moyamoya disease susceptibility variant RNF213 1 R4810K induces genomic instability by mitotic abnormality2013
- Author(s)
  Hitomi T, Habu T, Kobayashi H, Okuda H, Harada HK, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 439(4) Pages: 419-426
- Data Source
  KAKENHI-PROJECT-23501267
[Journal Article] Ablation of Rnf213 retards progression of diabetes in the Akita mouse2013
- Author(s)
  Kobayashi H, Yamazaki S, Takashima S, Liu W, Okuda H, Yan J, Fujii Y, Hitomi T, Harada KH, Habu T, Koizumi A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 432 Issue: 3 Pages: 519-525
- DOI
  10.1016/j.bbrc.2013.02.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00427, KAKENHI-PROJECT-10J05192, KAKENHI-PROJECT-12J05348, KAKENHI-PROJECT-22249020, KAKENHI-PROJECT-22590817, KAKENHI-PROJECT-23501267, KAKENHI-PROJECT-23590741, KAKENHI-PROJECT-23659329
[Journal Article] An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast2013
- Author(s)
  Horikoshi Y, Habu T, Matsumoto T
- Journal Title
  
  Cell Cycle
  
  Volume: 12(6) Pages: 961-971
- Data Source
  KAKENHI-PROJECT-23501267
[Journal Article] Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients.2013
- Author(s)
  Hitomi T, Habu T, Kobayashi H, Okuda H, Harada KH, Osafune K, Taura D, Sone M, Asaka I, Ameku T, Watanabe A, Kasahara T, Sudo T, Shiota F, Hashikata H, Takagi Y, Morito D, Miyamoto S, Nakao K, Koizumi A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 438(1): Issue: 1 Pages: 13-19
- DOI
  10.1016/j.bbrc.2013.07.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229013, KAKENHI-PROJECT-23501267, KAKENHI-PROJECT-23590741, KAKENHI-PUBLICLY-25122717, KAKENHI-PROJECT-25840024, KAKENHI-PROJECT-25893104
[Journal Article] A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules2012
- Author(s)
  Iimori M, Ozaki K, Chikashige Y, Habu T, Hiraoka Y, Maki T, Hayashi I, Obuse C, Matsumoto T
- Journal Title
  
  Exp. Cell Res
  
  Volume: 318(3) Pages: 262-275
- NAID
  120003874262
- Data Source
  KAKENHI-PROJECT-23501267
[Journal Article] A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules2012
- Author(s)
  Iimori, M.
- Journal Title
  
  Exp Cell Res
  
  Volume: 318 Issue: 3 Pages: 262-275
- DOI
  10.1016/j.yexcr.2011.11.006
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20114001, KAKENHI-PLANNED-20114002, KAKENHI-PLANNED-20114006, KAKENHI-PUBLICLY-22019020, KAKENHI-PROJECT-22370074, KAKENHI-PROJECT-23247003, KAKENHI-PROJECT-23501267, KAKENHI-PROJECT-24370071
[Journal Article] Expansion of Intronic GGCCTG Hexanucleotide Repeat in NOP56 Causes a Type of Spinocerebellar Ataxia (SCA36) Accompanied by Motor Neuron Involvement2011
- Author(s)
  Kobayashi H, Abe K, Matsuura T, Ikeda Y, Hitomi T, Akechi Y, Habu T, Yang WL, Okuda H, and Koizumi A
- Journal Title
  
  Am. J. Hum. Genet
  
  Volume: 89(1) Pages: 121-130
- Data Source
  KAKENHI-PROJECT-23501267
[Journal Article] Expansion of Intronic GGCCTG Hexanucleotide Repeat in NOP56 Causes a Type of Spinocerebellar Ataxia (SCA36) Accompanied by Motor Neuron Involvement2011
- Author(s)
  Hatasu Kobayashi, Koji Abe, Tohru Matsuura, Yoshio Ikeda, Toshiaki Hitomi, Yuji Akechi, Toshiyuki Habu, Wangyang Liu, Hiroko Okuda, Akio Koizumi
- Journal Title
  
  Am J Hum Genet
  
  Volume: 89(1) Issue: 1 Pages: 121-130
- DOI
  10.1016/j.ajhg.2011.05.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00427, KAKENHI-PROJECT-10J05192, KAKENHI-PROJECT-21390267, KAKENHI-PROJECT-21591084, KAKENHI-PROJECT-22659260, KAKENHI-PROJECT-23501267, KAKENHI-PROJECT-23590741
[Journal Article] Genistein, isoflavonoids in soybeans, prevents the formation of excess radiation-induced centrosomes via p21up-regulation2011
- Author(s)
  Shimada M, Kato A, Habu T, Komatsu K
- Journal Title
  
  Mutatation Research
  
  Volume: Volume 716 Issue: 1-2 Pages: 27-32
- DOI
  10.1016/j.mrfmmm.2011.07.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22710053, KAKENHI-PROJECT-22710054, KAKENHI-PROJECT-23241021, KAKENHI-PROJECT-23501267, KAKENHI-PROJECT-23651045
[Journal Article] Genistein, abundant isoflavonoids in soybeans, prevents the formation of excess radiation-induced centrosomes via p21 up-regulation2011
- Author(s)
  Shimada M, Kato A, Habu T and Komatsu K
- Journal Title
  
  Mutat Res
  
  Volume: 716(1-2) Pages: 27-32
- Data Source
  KAKENHI-PROJECT-23501267
[Journal Article] Conformation-specific binding of p31^<comet> to Mad2 antagonizes the function of Mad2 in the spindle checkpoint.2004
- Author(s)
  Guohong Xia, Xuelian Luo, Toshiyuki Habu, Josep Rizo, Tomohiro Matsumoto, Yu, H.
- Journal Title
  
  EMBO J. 23
  
  Pages: 3133-3143
- Data Source
  KAKENHI-PROJECT-15370085
[Presentation] 小胞体ストレス下でRNF213抑制により発現変動するタンパク質の解析2024
- Author(s)
  小林果, 土生敏行, 小泉昭夫, 及川伸二, 村田真理子,
- Organizer
  第94回衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-22K10487
[Presentation] Endoplasmic reticulum stress is inhibited by suppression of RNF213, a susceptibility gene for moyamoya disease.2023
- Author(s)
  Sharif Ahmed、土生敏行、Jiyeong Kim、奥田裕子、及川伸二、村田真理子、小泉昭夫、小林果
- Organizer
  第22回分子予防環境医学研究会大会
- Data Source
  KAKENHI-PROJECT-22K10487
[Presentation] もやもや病感受性遺伝子RNF213が小胞体ストレスに与える影響2023
- Author(s)
  小林果、Sharif Ahmed、土生敏行、及川伸二、小泉昭夫、村田真理子
- Organizer
  第93回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-22K10487
[Presentation] Effect of RNF213 suppression on endoplasmic reticulum stress2022
- Author(s)
  Sharif Ahmed, 小林果, 土生敏行, 原田浩二 , 手塚徹, Shohab Youssefian, 及川伸二, 村田真理子, 小泉昭夫
- Organizer
  第92回日本衛生学会学術総会
- Data Source
  KAKENHI-PLANNED-17H06397
[Presentation] Rnf213抑制はオスAkitaマウスと異なりメスAkitaマウスの糖尿病を改善しない2021
- Author(s)
  Sharif Ahmed, 小林果, 奥田裕子, 原田浩二, 土生敏行, Shohab Youssefian, 及川伸二, 村田真理子, 小泉昭夫
- Organizer
  第91回日本衛生学会学術総会
- Data Source
  KAKENHI-PLANNED-17H06397
[Presentation] もやもや病感受性遺伝子産物RNF213のユビキチンリガーゼ活性の検討2019
- Author(s)
  武田美都里, 手塚徹, 金びん秀, 西出旭, 崔廷米, 原田浩二, 小泉昭夫, ショハブ・ユーセフィアン
- Organizer
  第89回日本衛生学会学術総会
- Data Source
  KAKENHI-PLANNED-17H06397
[Presentation] もやもや病タンパク質 RNF213 の E3 ligase 活性の機能的評価2018
- Author(s)
  武田美都里、キムミンソ、小林果、原田浩二、土生敏行、小泉昭夫、ユーセフィアンショハブ
- Organizer
  日本衛生学会総会
- Data Source
  KAKENHI-PROJECT-15K07044
[Presentation] もやもや病タンパク質RNF213 のE3 ligase活性の機能的評価2018
- Author(s)
  武田美都里、キムミンソ、小林果、原田浩二、土生敏行、小泉昭夫、ユーセフィアン　ショハブ
- Organizer
  第88回　日本衛生学会学術総会
- Data Source
  KAKENHI-PLANNED-17H06397
[Presentation] In vitro and in vivo evidence on inhibition of angiogenesis by the Moyamoya susceptible gene and its mutation, RNF213 R4810K2015
- Author(s)
  Koizumi A, Kobayashi H, Matsuda Y, Hitomi T, Okuda H, Shioi H, Matsuda T, Imai H, Sone M, Taura D, Harada KH, Takagi Y, Miyamoto S, Habu T.
- Organizer
  4th International Moyamoya Meeting Berlin
- Place of Presentation
  Berlin
- Year and Date
  2015-07-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253047
[Presentation] In vitro and in vivo evidence on inhibition of angiogenesis by the Moyamoya susceptible gene and its mutation, RNF213 R4810K2015
- Author(s)
  Akio Koizumi, Hatasu Kobayashi, Yoshiko Matsuda, Toshiaki Hitomi, Hiroko Okuda, Hirotomo Shioi, Tetsuya Matsuda, Hirohiko Imai, Masakatsu Sone, Daisuke Taura, Kouji H. Harada, Yasushi Takagi, Susumu Miyamoto, Toshiyuki Habu
- Organizer
  4th International Moyamoya Meeting Berlin
- Place of Presentation
  Kaiserin-Friedrich-Haus, Germany
- Year and Date
  2015-07-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07044
[Presentation] PTP1B regulates the Moyamoya disease-associated E3 ligase, RNF213 and cellular dioxygenase activity to allow breast tumor survival in hypoxia2015
- Author(s)
  Robert S. Banh, Caterina Iorio, Richard Marcotte1, Yang Xu, Dan Cojocari, Anas Abdel Rahman, Judy Pawling, Ankit Sinha, Toshiaki Hitomi, Toshiyuki Habu, Akio Koizumi, Sarah Wilkins, Thomas Kislinger, Christopher J. Schofield, James W. Dennis, Bradly G. Wouters, and Benjamin G. Neel
- Organizer
  AACR 106th Annual Meeting 2015
- Place of Presentation
  Philadelphia　Convention Center, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07044
[Presentation] もやもや病感受性変異体Mysterin R4810K は有糸分裂異常によりゲノム不安定性を誘導する2014
- Author(s)
  人見敏明、小林果、土生敏行、原田浩二、小泉昭夫
- Organizer
  第13回分子予防環境医学研究会
- Place of Presentation
  和歌山県民文化会館
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] もやもや病感受性変異体Mysterin R4810Kは有糸分裂異常によりゲノム不安定性を誘導する2014
- Author(s)
  人見敏明、小林果、土生敏行、原田浩二、小泉昭夫
- Organizer
  第13回　分子予防環境医学研究会
- Place of Presentation
  和歌山県立文化会館
- Data Source
  KAKENHI-PROJECT-25253047
[Presentation] Mysterin遺伝子のR4810K多型はもやもや病特異的iPS細胞由来血管内皮細胞においてSecurinの発現抑制を介して血管形成能を低下させる2014
- Author(s)
  小林果、人見敏明、土生敏行、原田浩二、小泉昭夫
- Organizer
  第13回　分子予防環境医学研究会
- Place of Presentation
  和歌山県立文化会館
- Data Source
  KAKENHI-PROJECT-25253047
[Presentation] もやもや病感受性変異体Mysterin R4810Kは有糸分裂異常によりゲノム不安定性を誘導する2014
- Author(s)
  人見敏明、小林果、土生敏行、原田浩二、小泉昭夫
- Organizer
  第13回　分子予防環境医学研究会
- Place of Presentation
  和歌山県民文化会館
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] Mysterin 遺伝子のR4810K 多型はもやもや病特異的iPS 細胞由来血管内皮細胞においてSecurin の発現抑制を介して血管形成能を低下させる2014
- Author(s)
  小林果、人見敏明、土生敏行、原田浩二、小泉昭夫
- Organizer
  第13回分子予防環境医学研究会
- Place of Presentation
  和歌山県民文化会館
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] Mysterin遺伝子のR4810K多型はもやもや病特異的iPS細胞由来血管内皮細胞においてSecurinの発現抑制を介して血管形成能を低下させる2014
- Author(s)
  小林果、人見敏明、土生敏行、原田浩二、小泉昭夫
- Organizer
  第13回　分子予防環境医学研究会
- Place of Presentation
  和歌山県民文化会館
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] p53codon72 アリルpolymorphism とp53-p31comet 複合体関連解析2012
- Author(s)
  土生敏行
- Organizer
  第16回日本がん分子標的治療学会
- Place of Presentation
  北九州 (ポスター発表)
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] p53codon72アリルpolymorphismとp53-p31comet複合体関連解析2012
- Author(s)
  土生敏行
- Organizer
  日本がん分子標的治療学会　第１６回学術集会
- Place of Presentation
  北九州市
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] ALS 様運動神経障害を伴う新規脊髄小脳変性症(SCA36)の原因遺伝子発見2012
- Author(s)
  小林果、阿部康二、松浦徹、池田佳生、人見敏明、明地雄司、土生敏行、劉万洋、奥田裕子、小泉昭夫
- Organizer
  第11回分子予防環境医学研究会
- Place of Presentation
  川崎医科大学
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] Stress response controlled by differential binding of p31comet to p532012
- Author(s)
  Toshiyuki Habu, Tsuyoshi Ikura, Tomohiro Matsumoto
- Organizer
  The Sugahara menorial international symposium "Prospective Topics and charm of Radiation Biology"
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] NOP56 遺伝子イントロンにおける6塩基リピート拡張は脊髄小脳変性症36型を引き起こす2012
- Author(s)
  小林果, 阿部康二, 松浦徹, 池田佳生,人見敏明, 土生敏行, 劉万洋, 奥田裕子, 原田浩二, 小泉昭夫
- Organizer
  第82回日本衛生学会学術総会
- Place of Presentation
  京都大学吉田キャンパス
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] ストレス誘導型p53-p31comet複合体形成調節機構の解析2011
- Author(s)
  土生敏行
- Organizer
  第15回日本がん分子標的治療学会
- Place of Presentation
  東京ホテル日航東京
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] ストレス誘導型p53-p31comet 複合体形成調節機構の解析2011
- Author(s)
  土生敏行
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋 (ポスター発表)
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] ストレス誘導型p53-p31comet 複合体形成調節機構の解析2011
- Author(s)
  土生敏行
- Organizer
  第15回日本がん分子標的治療学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] p53-p31comet複合体による細胞死制御機構の解析2011
- Author(s)
  土生敏行
- Organizer
  第54回大会　日本癌学会
- Place of Presentation
  名古屋名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] p31cometによるp53の質的制御2008
- Author(s)
  土生敏行、松本智裕
- Organizer
  第25回染色体ワークショップ
- Place of Presentation
  熱海
- Year and Date
  2008-01-30
- Data Source
  KAKENHI-PROJECT-17013044
[Presentation] p31cometの細胞周期における機能2007
- Author(s)
  土生敏行、松本智裕
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-17013044
[Presentation] Moyamoya meets mitosis?
- Author(s)
  土生敏行
- Organizer
  生命科学シンポジウム
- Place of Presentation
  京都大学しらん会館
- Data Source
  KAKENHI-PROJECT-23501267
[Presentation] MysterinはIFNβによる抗血管形成シグナル経路のメディエーターとして働く
- Author(s)
  人見敏明、小林果、奥田裕子、曽根正勝、田浦大輔、原田浩二、土生敏行、小泉昭夫
- Organizer
  第85回　日本衛生学会学術総会
- Place of Presentation
  アバローム紀の国
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25253047
[Presentation] もやもや病感受性変異体は有糸分裂異常によりゲノム不安定性を誘導する
- Author(s)
  人見敏明、小林果、土生敏行、原田浩二、小泉昭夫
- Organizer
  第84回　日本衛生学会学術総会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-25253047
[Presentation] もやもや病特異的iPS細胞由来血管内皮細胞における血管形成能の低下
- Author(s)
  小林果、人見敏明、土生敏行、原田浩二、小泉昭夫
- Organizer
  第84回　日本衛生学会学術総会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-25253047

1. MATSUMOTO Tomohiro (80212223)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. KOIZUMI Akio (50124574)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
3. KOBAYASHI Hatasu (70542091)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
4. HARADA Koji (80452340)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
5. SONE Masakatsu (40437207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. MIYAMOTO Susumu (70239440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. TAKAGI Yasushi (40312227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. YAMAZAKI Satoru (70348796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HITOMI Toshiaki (90405275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
10. S Youssefian (00210576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 手塚徹 (50312319)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. KATO Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 中尾一和

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 森潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 井倉正枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. LIU Wangyang

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
17. SHOHAB YOUSSEFIAN

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

Habu Toshiyuki 土生 敏行

土生 敏行 ハブ トシユキ

HABU Toshiyuki 土生 敏行

Research Projects

Research Products

Co-Researchers

Role of RNF213 as a novel endoplasmic reticulum stress regulator in diabetes mellitus.

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Mechanism and processe of stenoocclusive vascular diseases caused by RNF213 mutation in inflammatory cellular society

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Analysis of reletionship between RNF213 moyamoya factor and autophagyPrincipal Investigator

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Molecular pathology of moyamoyta disease and its translational research toward prevention and drug development

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Analysis of p53 72SNP in stress responcePrincipal Investigator

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ゲノム安定性を維持するスピンドルチェックポイントの分子機構

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有糸分裂期の放射線応答

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The signal cascade of the spindle checkpoint

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[Book] Moyamoya Disease: Current Knowledge and Future Perspectives2021

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[Journal Article] Suppression of RNF213, a susceptibility gene for moyamoya disease, inhibits endoplasmic reticulum stress through SEL1L upregulation2022

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[Journal Article] UBC13 is an RNF213-associated E2 ubiquitin-conjugating enzyme, and Lysine 63-linked ubiquitination by the RNF213UBC13 axis is responsible for angiogenic activity.2021

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[Journal Article] The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress2017

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NAID

Data Source

[Journal Article] PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.2016

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Habu Toshiyuki 土生敏行

土生敏行ハブトシユキ

HABU Toshiyuki 土生敏行