TEZUKA Tohru 手塚徹

Researcher Number	50312319
Other IDs
Affiliation (Current)	2019: 京都大学, スーパーグローバルコース医学生命系ユニット, 特定講師
Affiliation (based on the past Project Information) *help	2018 – 2019: 京都大学, スーパーグローバルコース医学生命系ユニット, 特定講師 2009 – 2017: The University of Tokyo, 医科学研究所, 助教 2007: Tokyo Medical and Dental University, 難治疾患研究所, 特任講師 2000 – 2006: 東京大学, 医科学研究所, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / General medical chemistry / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Functional biochemistry / Complex systems / Neurochemistry/Neuropharmacology Except Principal Investigator General medical chemistry / Complex systems / Biological Sciences
Keywords	Principal Investigator チロシンリン酸化 / Src / シグナル伝達 / チロシンキナーゼ / 神経筋接合部 / 神経科学 / NMDA受容体 / 脳・神経 / Cbl / ユビキチン化 … More Except Principal Investigator 細胞内シグナル伝達 / 神経筋シナプス / 繊毛関連症候群 / 循環器疾患 / 組織炎症 / 繊毛関連症候群・炎症 / R4810K変異 / Wnt5a-Rorシグナル / 繊毛シグナル / 上皮管腔組織の破綻 / 運動機能障害 / エピジェネティック制御 / 非古典的Wntシグナル / 上皮管腔組織形成 / 平面細胞極性シグナル / 脳卒中 / シグナル伝達 / 癌の浸潤 / もやもや病 / 癌の浸潤・進展 / 神経科学 / 癌の浸潤転移 / 頂底極性シグナル / 線毛シグナル / 上皮管腔組織破綻 / アダプター分子 / 血管閉塞性病変 / 上皮間葉転換 / RNF213 Less

神経筋シナプス形成シグナルと形成不全の解明Ongoing
- Principal Investigator
  
  山梨裕司
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
Mechanism and processe of stenoocclusive vascular diseases caused by RNF213 mutation in inflammatory cellular societyOngoing
- Principal Investigator
  
  小泉昭夫
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
Develpment of a new method to treat neuromuscular diseasesPrincipal Investigator
- Principal Investigator
  
  Tezuka Tohru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The University of Tokyo
Molecular mechanisms of the formation and maintenance of NMJsPrincipal Investigator
- Principal Investigator
  
  TEZUKA Tohru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
細胞内リガンドによる受容体型チロシンキナーゼの活性化機構Principal Investigator
- Principal Investigator
  
  手塚徹
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Dysfunction of planar cell polarity signaling and its relationship with ciliopathies and cancer invasion and metastasis
- Principal Investigator
  
  MINAMI YASUHIRO
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Molecular signaling in neuromuscular synaptogenesis and myasthenia
- Principal Investigator
  
  YAMANASHI Yuji
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
Roles of Dok-7 and MuSK in neuromuscular synaptogenesisPrincipal Investigator
- Principal Investigator
  
  TEZUKA Tohru
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
Src及びCblファミリーによるチロシンリン酸化シグナルの正負の制御と脳高次機能Principal Investigator
- Principal Investigator
  
  手塚徹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
  The University of Tokyo
Src及びCblファミリーによるチロシンキナーゼシグナルの正負の制御と脳高次機能Principal Investigator
- Principal Investigator
  
  手塚徹
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of roles of Cbl-family proteins in the nervous system.Principal Investigator
- Principal Investigator
  
  TEZUKA Tohru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The University of Tokyo
Src及びCblファミリーによるチロシンキナーゼシグナルの正負の制御と脳高次機能Principal Investigator
- Principal Investigator
  
  手塚徹
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of NMDAR tyrosine phosphorylation by Src.Principal Investigator
- Principal Investigator
  
  TEZUKA Tohru
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The University of Tokyo
神経系におけるSrc型チロシンキナーゼの新規標的基質・遺伝子群の同定及び機能解析Principal Investigator
- Principal Investigator
  
  手塚徹
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
蛋白質分解を介してチロシンキナーゼシグナルを抑制するCblファミリーの機能解析Principal Investigator
- Principal Investigator
  
  手塚徹
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo

All 2017 2016 2015 2014 2013 2011 2010 2009 2007 Other

All Journal Article Presentation Book

[Book] 生体の科学(先天性筋無力症の分子基盤、Vol.62 No.2)2011
- Author(s)
  手塚徹、山梨裕司
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21790266
[Book] 生体の科学Vol.62 No.22011
- Author(s)
  手塚徹
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21790266
[Book] Cbl Proteins, Editor: Alex Tsygankov,
- Author(s)
  Tezuka, T., 他
- Publisher
  NOVA Publishers(未定)(in press)
- Data Source
  KAKENHI-PROJECT-18022013
[Journal Article] The carboxyl-terminal region of Dok-7 plays a key, but not essential, role in activation of muscle-specific receptor kinase MuSK and neuromuscular synapse formation.2017
- Author(s)
  Ryo Ueta, Tohru Tezuka, Yosuke Izawa, Sadanori Miyoshi, Satoru Nagatoishi, Kouhei Tsumoto, Yuji Yamanashi
- Journal Title
  
  J Biochem.
  
  Volume: 161 Pages: 269-277
- DOI
  10.1093/jb/mvw073
- Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J08885, KAKENHI-PROJECT-16K14575, KAKENHI-PROJECT-15K18500
[Journal Article] DOK7 gene therapy enhances motor activity and life span in ALS model mice2017
- Author(s)
  Miyoshi Sadanori、Tezuka Tohru、Arimura Sumimasa、Tomono Taro、Okada Takashi、Yamanashi Yuji
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 9 Pages: 880-889
- DOI
  10.15252/emmm.201607298
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-16K14575
[Journal Article] Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology.2016
- Author(s)
  Eguchi T, Tezuka T, Miyoshi S, and Yamanashi Y
- Journal Title
  
  Genes Cells
  
  Volume: 印刷中 Pages: 670-676
- DOI
  10.1111/gtc.12370
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25117708, KAKENHI-PROJECT-25460357, KAKENHI-PROJECT-14J08885, KAKENHI-PROJECT-16K14575
[Journal Article] The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses.2014
- Author(s)
  Tohru Tezuka, Akane Inoue, Taisuke Hoshi, Scott D. Weatherbee, Robert W. Burgess, Ryo Ueta, and Yuji Yamanashi
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111 Pages: 16556-16561
- DOI
  10.1073/pnas.1408409111
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249013, KAKENHI-PUBLICLY-25110711, KAKENHI-PROJECT-25460357
[Journal Article] DOK7 Gene Therapy Benefits Mouse Models of Diseases Characterized by Defects in the Neuromuscular Junction.2014
- Author(s)
  Sumimasa Arimura, Takashi Okada, Tohru Tezuka, Tomoko Chiyo, Yuko Kasahara, Toshiro Yoshimura, Masakatsu Motomura, Nobuaki Yoshida, David Beeson, Shin’ichi Takeda, Yuji Yamanashi
- Journal Title
  
  Science
  
  Volume: 345 Pages: 1505-1508
- DOI
  10.1126/science.1250744
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249013, KAKENHI-PROJECT-24500472, KAKENHI-PUBLICLY-25110711, KAKENHI-PROJECT-25460357, KAKENHI-PROJECT-25461318, KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-26461302, KAKENHI-PROJECT-26860273
[Journal Article] Adaptor protein complex of FRS2b and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation2013
- Author(s)
  後藤　典子
- Journal Title
  
  Cancer Science
  
  Volume: 104 Pages: 345-352
- DOI
  10.1111/cas.12086
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130009, KAKENHI-PROJECT-23510261, KAKENHI-PROJECT-23659192, KAKENHI-PROJECT-23659626, KAKENHI-PUBLICLY-24121705, KAKENHI-PROJECT-24700968, KAKENHI-PROJECT-25460357, KAKENHI-PROJECT-23390087
[Journal Article] Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.2013
- Author(s)
  Hoshi T, Tezuka T, Yokoyama K, Iemura S-I, Natsume T, and Yamanashi Y
- Journal Title
  
  FEBS Letter
  
  Volume: 587 Pages: 3749-3754
- DOI
  10.1016/j.febslet.2013.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117511, KAKENHI-PROJECT-23249013, KAKENHI-PLANNED-24115007, KAKENHI-PUBLICLY-24121705, KAKENHI-PUBLICLY-25110711, KAKENHI-PUBLICLY-25117708, KAKENHI-PROJECT-25460357
[Journal Article] Protocadherin 17 regulates presynaptic assembly in topographic corticobasal ganglia circuits.2013
- Author(s)
  Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T
- Journal Title
  
  Neuron.
  
  Volume: 78(5) Pages: 839-854
- DOI
  10.1016/j.neuron.2013.03.031
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115006, KAKENHI-PROJECT-21229006, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23300119, KAKENHI-PROJECT-23700411, KAKENHI-PUBLICLY-24121705, KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-24790187, KAKENHI-PROJECT-25000015, KAKENHI-PUBLICLY-25110716, KAKENHI-PROJECT-25250003, KAKENHI-PROJECT-25430037, KAKENHI-PROJECT-25460357, KAKENHI-PROJECT-25640011, KAKENHI-PROJECT-25640033
[Journal Article] NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala.2010
- Author(s)
  Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T.
- Journal Title
  
  Mol Brain. 3
  
  Pages: 37-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790266
[Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour.2009
- Author(s)
  Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T.
- Journal Title
  
  EMBO J. 28(23)
  
  Pages: 3717-3729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790266
[Journal Article] The roles of Dok family adapters in immunoreceptor signaling.2009
- Author(s)
  Mashima R, Hishida Y, Tezuka T, Yamanashi Y.
- Journal Title
  
  Immunol Rev. 232(1)
  
  Pages: 273-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790266
[Presentation] 神経筋接合部の形成増強による筋萎縮性側索硬化症（ALS）マウスの病態改善と延命2017
- Author(s)
  三好貞徳、手塚徹、有村純暢、伴野太郎、岡田尚巳、山梨裕司
- Organizer
  日本筋学会
- Data Source
  KAKENHI-PROJECT-16K14575
[Presentation] 生後のNMJの維持におけるDok-7の役割2016
- Author(s)
  江口貴大、手塚徹、三好貞徳、山梨裕司
- Organizer
  第２回日本筋学会
- Place of Presentation
  国立精神・神経医療研究センター（東京都小平市）
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-16K14575
[Presentation] 神経筋接合部の出生後の維持におけるAgrinの新たな役割2015
- Author(s)
  手塚徹、井上茜、星太輔、Weatherbee SD、Burgess RW、植田亮、山梨裕司
- Organizer
  日本筋学会
- Place of Presentation
  国立研究開発法人国立精神・神経医療研究センター（東京都小平市）
- Year and Date
  2015-08-08
- Data Source
  KAKENHI-PROJECT-25460357
[Presentation] The Novel NYAP phosphoprotein family couples activation of phosphoinositide 3-kinase (PI3K) p85 with the cytoskeletal WAVE signaling pathway in the brain.2009
- Author(s)
  横山一剛、手塚徹、小谷政晴、中澤敬信、星名直祐、井上毅、霜田靖、角田茂、須藤カツ子、渡邉和忠、岩倉洋一郎、山本雅
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21790266
[Presentation] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior.2009
- Author(s)
  中澤敬信、谷口幸子、谷村あさみ、城山優治、手塚徹、狩野方伸、真鍋俊也、山本雅
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21790266
[Presentation] Cblファミリー蛋白質による表皮形成制御2007
- Author(s)
  手塚徹, 他
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18022013

1. YAMANASHI Yuji (40202387)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. MINAMI YASUHIRO (70229772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. MASHIMA Ryuichi (00401365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NUREKI Osamu (10272460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NATSUME Tohru (00357683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKEDA Shin'ICHI (90171644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. MOTOMURA Masakatsu (70244093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 植田亮 (10445025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 小泉昭夫 (50124574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. S Youssefian (00210576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 原田浩二 (80452340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAGATOISHI Satoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. NAKAZAWA Takanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. Kano Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. Hoshi Eiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. Fukata Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. Yamamoto Nobuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 後藤典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 水谷アンナ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 岡田尚巳

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 岡田浩典

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 吉村俊朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 笠原優子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 山本雅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 小林和人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 高尾昌樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 阿部修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 渡辺雅彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 青木茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 高田昌彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 井上和秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 山崎美和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 平野伸二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TEZUKA Tohru 手塚 徹

Research Projects

Research Products

Co-Researchers

神経筋シナプス形成シグナルと形成不全の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism and processe of stenoocclusive vascular diseases caused by RNF213 mutation in inflammatory cellular societyOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Develpment of a new method to treat neuromuscular diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of the formation and maintenance of NMJsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞内リガンドによる受容体型チロシンキナーゼの活性化機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dysfunction of planar cell polarity signaling and its relationship with ciliopathies and cancer invasion and metastasis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular signaling in neuromuscular synaptogenesis and myasthenia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of Dok-7 and MuSK in neuromuscular synaptogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Src及びCblファミリーによるチロシンリン酸化シグナルの正負の制御と脳高次機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Src及びCblファミリーによるチロシンキナーゼシグナルの正負の制御と脳高次機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of roles of Cbl-family proteins in the nervous system.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Src及びCblファミリーによるチロシンキナーゼシグナルの正負の制御と脳高次機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of NMDAR tyrosine phosphorylation by Src.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

TEZUKA Tohru 手塚徹