Yasuda Hiroyuki 安田浩之

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YASUDA Hiroyuki 安田浩之

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Researcher Number	70365261
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 慶應義塾大学, 医学部(信濃町), 准教授 2016 – 2021: 慶應義塾大学, 医学部(信濃町), 講師 2017: 慶應義塾大学, 医学部(信濃町), 専任講師 2016: 慶應義塾大学, 医学部(信濃町), 助教 2013 – 2015: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 50:Oncology and related fields / Basic Section 50010:Tumor biology-related / Tumor diagnostics Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Respiratory organ internal medicine / Basic Section 56020:Orthopedics-related / Basic Section 56030:Urology-related
Keywords	Principal Investigator 肺癌 / 癌 / オルガノイド / 分子標的治療薬 / 癌代謝 / 酸素療法 / シグナル / シグナル経路異常 / 耐性化 / 遺伝子変異 … More / 希少肺癌 / 難治性肺癌 / 臨床検体 / ATP / ATP競合型チロシンキナーゼ阻害剤 / ATP濃度 / ＡＴＰ濃度 / 抗癌剤 / 癌細胞の代謝 / Mass-spectrometry / 代謝 / 血管新生阻害薬 / 薬剤感受性 / EGFR遺伝子 … More Except Principal Investigator 肺癌 / オルガノイド / 薬剤感受性 / 骨腫瘍 / 作用機序 / 抗体薬物複合体 / Patritumab-Deruxtecan / 個別化治療 / シングルセル解析 / 薬剤耐性 / 前立腺癌 / 小細胞肺癌 / スーパーコンピューター / 稀な遺伝子異常 / EGFR exon 20挿入遺伝子 / 臨床研究 / 稀な遺伝子編 / 臨床試験 / multiomics解析 / KRAS遺伝子変異 / 医師主導治験 / EGFR遺伝子変異 / 稀な遺伝子変異 / マクロファージ / 線維芽細胞増殖因子 / FGF / 代謝因子 / トランスレーショナルリサーチ / KRAS / EML4-ALK / EGFR / ドライバーがん遺伝子 / イメージングマススペクトロメトリ / バイオバンク / ゲノミクス / メタボロミクス / AMPK / Nintedanib / Bevacizumab / 高濃度酸素暴露 / Imaging MS / 肺がん / メタボローム解析 / がん代謝 Less

治療抵抗性肺癌オルガノイドライブラリーを用いた獲得耐性機構の本態解明Principal Investigator
- Principal Investigator
  
  安田浩之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Keio University
Investigation using organoid library to realize personalized medicine for squamous cell carcinoma of the lung
- Principal Investigator
  
  浜本純子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Keio University
肺癌細胞株を用いたPatritumab-Deruxtecanのバイオマーカー、作用・耐性機序の探索
- Principal Investigator
  
  池村辰之介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  University of Yamanashi
軟骨系腫瘍オルガノイドを用いた軟骨肉腫腫瘍化の分子機構解明と新規薬物治療開発
- Principal Investigator
  
  中山タラントロバート
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Keio University
Elucidation of the molecular control mechanism of refractory prostate cancer that includes lineage plasticity and establishment of individualized treatment strategies
- Principal Investigator
  
  小坂威雄
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
患者由来癌オルガノイドを用いたがん補助診断ツールの開発
- Principal Investigator
  
  扇野圭子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Keio University
酸素を用いた癌治療法の開発Principal Investigator
- Principal Investigator
  
  安田浩之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Keio University
小細胞肺癌オルガノイドを用いた小細胞肺癌発癌過程の理解
- Principal Investigator
  
  浜本純子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Keio University
Clarification of signal pathway dependency of lung cancer using lung cancer organoid libraryPrincipal Investigator
- Principal Investigator
  
  Yasuda Hiroyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Keio University
Establishment of lung cancer and normal lung organoid library
- Principal Investigator
  
  Hamamoto Junko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Keio University
Establishment of strategy for the treatment of lung cancer harboring rare mutations
- Principal Investigator
  
  Soejima Kenzo
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  University of Yamanashi
  Keio University
Development of translational research system to overcome refractory or rare lung cancerPrincipal Investigator
- Principal Investigator
  
  YASUDA Hiroyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
Precision medicine based on matabolic pathways in lung cancer
- Principal Investigator
  
  Soejima Kenzo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
Clinical application of Imaging Mass-spectrometry in cancer fileldPrincipal Investigator
- Principal Investigator
  
  Yasuda Hiroyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor diagnostics
- Research Institution
  Keio University
肺癌における線維芽細胞増殖因子の多機能性とその制御に向けた新展開
- Principal Investigator
  
  別役智子
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
Developing effective combination therapy with ATP competitive tyrosine kinase inhibitorsPrincipal Investigator
- Principal Investigator
  
  Yasuda Hiroyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
Drug sensitivity of lung cancers harboring novel or rare EGFR mutationsPrincipal Investigator
- Principal Investigator
  
  YASUDA Hiroyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma2023
- Author(s)
  Ebisudani Toshiki, Hamamoto Junko, Togasaki Kazuhiro, et al.
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 3 Pages: 112212-112212
- DOI
  10.1016/j.celrep.2023.112212
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16028, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-21H02765, KAKENHI-PROJECT-22KJ2666, KAKENHI-PROJECT-20K08574, KAKENHI-PROJECT-22H04995
[Journal Article] Population Pharmacokinetics, Pharmacogenomics, and Adverse Events of Osimertinib and its Two Active Metabolites, AZ5104 and AZ7550, in Japanese Patients with Advanced Non-small Cell Lung Cancer: a Prospective Observational Study2023
- Author(s)
  Ishikawa Emi、Yokoyama Yuta、Nakada Hideo、Suehiro Naoya、Nakaya Naoki、Nakajima Hideo、Ikemura Shinnosuke、Kawada Ichiro、Yasuda Hiroyuki、Terai Hideki、Jibiki Aya、Kawazoe Hitoshi、Soejima Kenzo、Muramatsu Hiroshi、Suzuki Sayo、Nakamura Tomonori
- Journal Title
  
  Investigational New Drugs
  
  Volume: 41 Issue: 1 Pages: 122-133
- DOI
  10.1007/s10637-023-01328-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03671
[Journal Article] Real-world clinical practice for advanced non-small-cell lung cancer in the very elderly: A retrospective multicenter analysis2022
- Author(s)
  Fukushima Takahiro、Oyamada Yoshitaka、Ikemura Shinnosuke、Nukaga Shigenari、Inoue Takashi、Arai Daisuke、Ohgino Keiko、Kuroda Aoi、Ishioka Kota、Sakamaki Fumio、Suzuki Yusuke、Terai Hideki、Yasuda Hiroyuki、Kawada Ichiro、Fukunaga Koichi、Soejima Kenzo
- Journal Title
  
  Clinical Lung Cancer
  
  Volume: 23 Issue: 6 Pages: 532-541
- DOI
  10.1016/j.cllc.2022.05.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03671
[Journal Article] Most Important Things and Associated Factors With Prioritizing Daily Life in Patients With Advanced Lung Cancer2022
- Author(s)
  Kameyama N, Sato T, Arai D, Fujisawa D, Takeuchi M, Nakachi I, Kawada I, Yasuda H, Ikemura S, Terai H, Nukaga S, Nakano Y, Hirano T, Minematsu N, Asakura T, Kamatani T, Tanaka K, Suzuki S, Miyawaki M, Naoki K, Fukunaga K, Soejima K
- Journal Title
  
  JCO Oncol Pract.
  
  Volume: 18(12) Issue: 12 Pages: e1977-e1986
- DOI
  10.1200/op.22.00124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11081, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K07476
[Journal Article] Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening2021
- Author(s)
  Ebisudani Toshiki、Sugimoto Shinya、Haga Kei、Mitsuishi Akifumi、Takai-Todaka Reiko、Fujii Masayuki、Toshimitsu Kohta、Hamamoto Junko、Sugihara Kai、Hishida Tomoyuki、Asamura Hisao、Fukunaga Koichi、Yasuda Hiroyuki、Katayama Kazuhiko、Sato Toshiro
- Journal Title
  
  Cell Reports
  
  Volume: 35 Issue: 10 Pages: 109218-109218
- DOI
  10.1016/j.celrep.2021.109218
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08610, KAKENHI-PROJECT-20H03757, KAKENHI-PROJECT-21K08496, KAKENHI-PROJECT-20H03746
[Journal Article] Longitudinal Assessment of Prognostic Understanding in Patients with Advanced Lung Cancer and Its Association with Their Psychological Distress.2021
- Author(s)
  Arai D, Sato T, Nakachi I, Fujisawa D, Takeuchi M, Sato Y, Kawada I, Yasuda H, Ikemura S, Terai H, Nukaga S, Inoue T, Nakamura M, Oyamada Y, Terashima T, Sayama K, Saito F, Sakamaki F, Naoki K, Fukunaga K, Soejima K.
- Journal Title
  
  Oncologist
  
  Volume: 26 Issue: 12 Pages: e2265-e2273
- DOI
  10.1002/onco.13973
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K07476
[Journal Article] Functional dissection of the KRAS G12C mutation by comparison among multiple oncogenic driver mutations in a lung cancer cell line model2021
- Author(s)
  Kobayashi Keigo、Terai Hideki、Yasuda Hiroyuki、Hamamoto Junko、Hayashi Yuichiro、Takeuchi Osamu、Mitsuishi Yoichiro、Masuzawa Keita、Manabe Tadashi、Ikemura Shinnosuke、Kawada Ichiro、Suzuki Yukio、Soejima Kenzo、Fukunaga Koichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 534 Pages: 1-7
- DOI
  10.1016/j.bbrc.2020.11.110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17190, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K08184
[Journal Article] Effect of renin-angiotensin system inhibitors on pemetrexed plus platinum-induced hematological toxicities: a multicenter retrospective study using three propensity score analyses.2021
- Author(s)
  Arami T, Kawazoe H, Uozumi R, Hashimoto H, Egami S, Sakiyama N, Ohe Y, Nakada H, Aomori T, Ikemura S, Yasuda H, Kawada I, Fukunaga K, Soejima K, Yamaguchi M, Nakamura T.
- Journal Title
  
  Pharmazie
  
  Volume: 76 Pages: 266-271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03671
[Journal Article] Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer2021
- Author(s)
  Ishioka Kota、Yasuda Hiroyuki、Hamamoto Junko、Terai Hideki、Emoto Katsura、Kim Tae-Jung、Hirose Shigemichi、Kamatani Takashi、Mimaki Sachiyo、Arai Daisuke、Ohgino Keiko、Tani Tetsuo、Masuzawa Keita、et al
- Journal Title
  
  Cancer Research
  
  Volume: 81 Issue: 14 Pages: 3916-3929
- DOI
  10.1158/0008-5472.can-20-4048
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17190, KAKENHI-PROJECT-20H00545, KAKENHI-PROJECT-19H03671
[Journal Article] A phase I/II study of osimertinib in EGFR exon 20 insertion mutation-positive non-small cell lung cancer. Lung Cancer.2021
- Author(s)
  Yasuda H, Ichihara E, Sakakibara-Konishi J, Zenke Y, Takeuchi S, Morise M, Hotta K, Sato M, Matsumoto S, Tanimoto A, Matsuzawa R, Kiura K, Takashima Y, Yano S, Koyama J, Fukushima T, Hamamoto J, Terai H, Ikemura S, Takemura R, Goto K, Soejima K.
- Journal Title
  
  Lung Cancer
  
  Volume: 162 Pages: 140-146
- DOI
  10.1016/j.lungcan.2021.10.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-19K07910
[Journal Article] Trends of concerns from diagnosis in patients with advanced lung cancer and their family caregivers: A 2-year longitudinal study.2021
- Author(s)
  Sato T, Fujisawa D, Arai D, Nakachi I, Takeuchi M, Nukaga S, Kobayashi K, Ikemura S, Terai H, Yasuda H, Kawada I, Sato Y, Satomi R, Takahashi S, Haraguchi Hashiguchi M, Nakamura M, Oyamada Y, Terashima T, Sayama K, Saito F, Sakamaki F, Inoue T, Naoki K, Fukunaga K, Soejima K.
- Journal Title
  
  Palliative Medicine
  
  Volume: Mar 24 Issue: 5 Pages: 943-951
- DOI
  10.1177/02692163211001721
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07476, KAKENHI-PROJECT-19H03671
[Journal Article] Intracellular levels of reactive oxygen species correlate with ABT‐263 sensitivity in non‐small‐cell lung cancer cells2020
- Author(s)
  Ohgino Keiko、Terai Hideki、Yasuda Hiroyuki、Nukaga Shigenari、Hamamoto Junko、Tani Tetsuo、Kuroda Aoi、Arai Daisuke、Ishioka Kota、Masuzawa Keita、Ikemura Shinnosuke、Kawada Ichiro、Naoki Katsuhiko、Fukunaga Koichi、Soejima Kenzo
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 10 Pages: 3793-3801
- DOI
  10.1111/cas.14569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17190, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K08184
[Journal Article] Adoptive transfer of zoledronate-expanded autologous Vγ9Vδ2 T-cells in patients with treatment-refractory non-small-cell lung cancer: a multicenter, open-label, single-arm, phase 2 study2020
- Author(s)
  Kakimi Kazuhiro、Matsushita Hirokazu、Masuzawa Keita、et al.
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 8 Issue: 2 Pages: 2-2
- DOI
  10.1136/jitc-2020-001185
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17190, KAKENHI-PROJECT-19H03528, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-20J10564
[Journal Article] IGF2 Autocrine-Mediated IGF1R Activation Is a Clinically Relevant Mechanism of Osimertinib Resistance in Lung Cancer2020
- Author(s)
  Manabe Tadashi、Yasuda Hiroyuki、Terai Hideki、Kagiwada Harumi、Hamamoto Junko、Ebisudani Toshiki、Kobayashi Keigo、Masuzawa Keita、Ikemura Shinnosuke、Kawada Ichiro、Hayashi Yuichiro、Fukui Kazuhiko、Horimoto Katsuhisa、Fukunaga Koichi、Soejima Kenzo
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 印刷中 Issue: 4 Pages: 549-559
- DOI
  10.1158/1541-7786.mcr-19-0956
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18J12516, KAKENHI-PROJECT-19J12401, KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-18K15959, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K08184
[Journal Article] SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in Non-Small Cell Lung Cancer Cells2020
- Author(s)
  Terai Hideki、Hamamoto Junko、Emoto Katsura、Masuda Takeshi、Manabe Tadashi、Kuronuma Satoshi、Kobayashi Keigo、Masuzawa Keita、Ikemura Shinnosuke、Nakayama Sohei、Kawada Ichiro、Suzuki Yusuke、Takeuchi Osamu、Suzuki Yukio、Ohtsuki Sumio、Yasuda Hiroyuki、Soejima Kenzo、Fukunaga Koichi
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 19 Issue: 2 Pages: 317-328
- DOI
  10.1158/1541-7786.mcr-20-0664
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05544, KAKENHI-PROJECT-20K17190, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K08184
[Journal Article] Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations2019
- Author(s)
  Ikemura S, Yasuda H, Matsumoto S, Kamada M, Hamamoto J, Masuzawa K, Kobayashi K, Manabe T, Arai D, Nakachi I, Kawada I, Ishioka K, Nakamura M, Namkoong H, Naoki K, Ono F, Araki M, Kanada R, Ma B, Hayashi Y, Mimaki S, Yoh K, Kobayashi SS, Kohno T, Okuno Y, Goto K, Tsuchihara K, Soejima K.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: Epub ahead of print Issue: 20 Pages: 10025-10030
- DOI
  10.1073/pnas.1819430116
- NAID
  120006799239
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18J12516, KAKENHI-PROJECT-16K21746
[Journal Article] Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations.2019
- Author(s)
  Hasegawa H, Yasuda H, Hamamoto J, Masuzawa K, Tani T, Nukaga S, Hirano T, Kobayashi K, Manabe T, Terai H, Ikemura S, Kawada I, Naoki K, Soejima K.
- Journal Title
  
  Lung Cancer
  
  Volume: 127 Pages: 146-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09667
[Journal Article] Monomer Preference of EGFR Tyrosine Kinase Inhibitors Influences the Synergistic Efficacy of Combination Therapy with Cetuximab.2019
- Author(s)
  Oashi A, Yasuda H, Kobayashi K, Tani T, Hamamoto J, Masuzawa K, Manabe T, Terai H, Ikemura S, Kawada I, Naoki K, Soejima K
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 18 Issue: 9 Pages: 1593-1601
- DOI
  10.1158/1535-7163.mct-18-1036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18J12516, KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-18K08184
[Journal Article] Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations2019
- Author(s)
  Hasegawa H, Yasuda H, Hamamoto J, Masuzawa K, Tani T, Nukaga S, Hirano T, Kobayashi K, Manabe T, Terai H, Ikemura S, Kawada I, Naoki K, Soejima K.
- Journal Title
  
  Lung Cancer
  
  Volume: 127 Pages: 146-52
- DOI
  10.1016/j.lungcan.2018.11.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-18J12516, KAKENHI-PROJECT-18K08184
[Journal Article] A phase II trial of induction of erlotinib followed by cytotoxic chemotherapy for EGFR mutation-positive non-squamous non-small cell lung cancer patients.2019
- Author(s)
  Tani T, Naoki K, Yasuda H, Arai D, Ishioka K, Ohgino K, Yoda S, Nakayama S, Satomi R, Terai H, Ikemura S, Sato T, Soejima K.
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 84 Issue: 5 Pages: 1065-1071
- DOI
  10.1007/s00280-019-03934-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-17K09667
[Journal Article] Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts.2019
- Author(s)
  Hegab AE, Ozaki M, Kameyama N, Gao J, Kagawa S, Yasuda H, Soejima K, Yin Y, Guzy RD, Nakamura Y, Ornitz DM, Betsuyaku T.
- Journal Title
  
  J Pathol
  
  Volume: 249 Issue: 2 Pages: 193-205
- DOI
  10.1002/path.5290
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-17K09667
[Journal Article] TAS6417/CLN-081 Is a Pan-Mutation-Selective EGFR Tyrosine Kinase Inhibitor with a Broad Spectrum of Preclinical Activity against Clinically Relevant EGFR Mutations.2019
- Author(s)
  Udagawa H, Hasako S, Ohashi A, Fujioka R, Hakozaki Y, Shibuya M, Abe N, Komori T, Haruma T, Terasaka M, Fujita R, Hashimoto A, Funabashi K, Yasuda H, Miyadera K, Goto K, Costa DB, Kobayashi SS.
- Journal Title
  
  Mol Cancer Res
  
  Volume: 17(11) Issue: 11 Pages: 2233-2243
- DOI
  10.1158/1541-7786.mcr-19-0419
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-16K21746
[Journal Article] Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms.2018
- Author(s)
  Hegab AE, Ozaki M, Kagawa S, Hamamoto J, Yasuda H, Naoki K, Soejima K, Yin Y, Kinoshita T, Yaguchi T, Kawakami Y, Ornitz DM, Betsuyaku T
- Journal Title
  
  Lung Cancer
  
  Volume: 119 Pages: 25-35
- DOI
  10.1016/j.lungcan.2018.02.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229, KAKENHI-PROJECT-26221005
[Journal Article] Real-world Efficacy and Safety of Nivolumab for Advanced Non?Small-cell Lung Cancer: A Retrospective Multicenter Analysis2018
- Author(s)
  Kobayashi Keigo、Nakachi Ichiro、Naoki Katsuhiko、Satomi Ryosuke、Nakamura Morio、Inoue Takashi、Tateno Hiroki、Sakamaki Fumio、Sayama Koichi、Terashima Takeshi、Koh Hidefumi、Abe Takayuki、Nishino Makoto、Arai Daisuke、Yasuda Hiroyuki、Kawada Ichiro、Soejima Kenzo、Betsuyaku Tomoko
- Journal Title
  
  Clinical Lung Cancer
  
  Volume: 19 Issue: 3 Pages: e349-e358
- DOI
  10.1016/j.cllc.2018.01.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08564, KAKENHI-PROJECT-15K09229
[Journal Article] Pharmacological and Structural　Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase　Inhibitor, in EGFR-Mutated Non-Small Cell Lung Cancer.2018
- Author(s)
  Hirano T, Yasuda H, Hamamoto J, Nukaga S, Masuzawa K, Kawada I, Naoki K, Niimi　T, Mimasu S, Sakagami H, Soejima K, Betsuyaku T
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 17(4) Issue: 4 Pages: 740-750
- DOI
  10.1158/1535-7163.mct-17-1033
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-15K09229, KAKENHI-PROJECT-18J12516
[Journal Article] Intermittent Exposure to Cigarette　Smoke Increases Lung Tumors and the Severity of Emphysema More Than Continuous　Exposure.2018
- Author(s)
  Kameyama N, Chubachi S, Hegab AE, Yasuda H, Kagawa S, Tsutsumi A, Fukunaga K, Shimoda M, Kanai Y, Soejima K, Betsuyaku T.
- Journal Title
  
  Am J Respir Cell Mol Biol.
  
  Volume: Epub ahead of print Issue: 2 Pages: 179-188
- DOI
  10.1165/rcmb.2017-0375oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-15H04833, KAKENHI-PROJECT-15K09229, KAKENHI-PROJECT-17K16063
[Journal Article] Targeted therapy-induced facial skin toxicities: Impact on quality of life in cancer patients2018
- Author(s)
  Yagasaki Kaori、Komatsu Hiroko、Soejima Kenzo、Naoki Katsuhiko、Kawada Ichiro、Yasuda Hiroyuki、Hamamoto Yasuo
- Journal Title
  
  Asia-Pacific Journal of Oncology Nursing
  
  Volume: 2 Issue: 2 Pages: 172-177
- DOI
  10.4103/apjon.apjon_74_17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05081, KAKENHI-PROJECT-15K09229
[Journal Article] Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms.2018
- Author(s)
  Hegab AE, Ozaki M, Kagawa S, Hamamoto J, Yasuda H, Naoki K, Soejima K, Yin Y, Kinoshita T, Yaguchi T, Kawakami Y, Ornitz DM, Betsuyaku T.
- Journal Title
  
  Lung Cancer.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04833
[Journal Article] Overcoming EGFR Bypass Signal-Induced Acquired Resistance to ALK Tyrosine Kinase Inhibitors in ALK-Translocated Lung Cancer.2017
- Author(s)
  Miyawaki M, Yasuda H, Tani T, Hamamoto J, Arai D, Ishioka K, Ohgino K, Nukaga S, Hirano T, Kawada I, Naoki K, Hayashi Y, Betsuyaku T, Soejima K.
- Journal Title
  
  Ｍｏｌｅｃｕｌａｒ　Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ
  
  Volume: 15(1） Issue: 1 Pages: 106-114
- DOI
  10.1158/1541-7786.mcr-16-0211
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05666, KAKENHI-PROJECT-15K14398, KAKENHI-PROJECT-15K09229
[Journal Article] Clinical and pathological characteristics of EGFR mutation in operable early-stage lung adenocarcinoma2017
- Author(s)
  Yotsukura M, Yasuda H, Shigenobu T, Kaseda K, Masai K, Hayashi Y, Hishida T, Ohtsuka T, Naoki K, Soejima K, Betsuyaku T, Asamura H
- Journal Title
  
  Lung Cancer
  
  Volume: 109 Pages: 45-51
- DOI
  10.1016/j.lungcan.2017.04.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10699, KAKENHI-PROJECT-15K09229
[Journal Article] Amplification of EGFR Wild-Type Alleles in Non-Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors.2017
- Author(s)
  Nukaga S, Yasuda H, Tsuchihara K, Hamamoto J, Masuzawa K, Kawada I, Naoki K, Matsumoto S, Mimaki S, Ikemura S, Goto K, Betsuyaku T, Soejima K.
- Journal Title
  
  Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ
  
  Volume: 77（８） Issue: 8 Pages: 2078-2089
- DOI
  10.1158/0008-5472.can-16-2359
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05666, KAKENHI-PROJECT-15K14398, KAKENHI-PROJECT-15K09229, KAKENHI-PROJECT-16K19465
[Journal Article] Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung2017
- Author(s)
  Kuroda Aoi、Hegab Ahmed E.、Jingtao Gao、Yamashita Shuji、Hizawa Nobuyuki、Sakamoto Tohru、Yamada Hideyasu、Suzuki Satoshi、Ishii Makoto、Namkoong Ho、Asakura Takanori、Ozaki Mari、Yasuda Hiroyuki、Hamamoto Junko、Kagawa Shizuko、Soejima Kenzo、Betsuyaku Tomoko
- Journal Title
  
  Respir Res
  
  Volume: 18 Issue: 1 Pages: 69-69
- DOI
  10.1186/s12931-017-0554-5
- NAID
  120007129115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09603, KAKENHI-PROJECT-15H04827, KAKENHI-PROJECT-16J07163, KAKENHI-PROJECT-15K09229, KAKENHI-PROJECT-15K09580
[Journal Article] Characterization of the efficacies of osimertinib and　nazartinib against cells expressing clinically relevant epidermal growth factor　receptor mutations.2017
- Author(s)
  Masuzawa K, Yasuda H, Hamamoto J, Nukaga S, Hirano T, Kawada I, Naoki K,　Soejima K, Betsuyaku T.
- Journal Title
  
  Oncotarget.
  
  Volume: 8(62) Issue: 62 Pages: 105479-105491
- DOI
  10.18632/oncotarget.22297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-15K09229
[Journal Article] Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma.2017
- Author(s)
  Nishino M, Ozaki M, Hegab AE, Hamamoto J, Kagawa S, Arai D, Yasuda H, Naoki K, Soejima K, Saya H, Betsuyaku T
- Journal Title
  
  J Cancer
  
  Volume: 8 Issue: 10 Pages: 1774-1785
- DOI
  10.7150/jca.19732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09229
[Journal Article] Erlotinib as second- or third-line treatment in elderly patients with advanced non-small cell lung cancer: Keio Lung Oncology Group Study 001 (KLOG001).2017
- Author(s)
  Miyawaki M, Naoki K, Yoda S, Nakayama S, Satomi R, Sato T, Ikemura S, Ohgino K, Ishioka K, Arai D, Namkoong H, Otsuka K, Miyazaki M, Tani T, Kuroda A, Nishino M, Yasuda H, Kawada I, Koh H, Nakamura M, Terashima T, Sakamaki F, Sayama K, Betsuyaku T, Soejima K
- Journal Title
  
  Mol Clin Oncol
  
  Volume: 6 Issue: 3 Pages: 409-414
- DOI
  10.3892/mco.2017.1154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09229
[Journal Article] Osimertinib for EGFR T790M Mutation-Positive Non-Small Cell Lung Cancer.2017
- Author(s)
  Soejima K, Yasuda H, Hirano T
- Journal Title
  
  Expert Rev Clin Pharmacol
  
  Volume: 10 Issue: 1 Pages: 31-38
- DOI
  10.1080/17512433.2017.1265446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09229
[Journal Article] Non-small cell lung cancer PC-9 cells exhibit　increased sensitivity to gemcitabine and vinorelbine upon acquiring resistance to　EGFR-tyrosine kinase inhibitors.2017
- Author(s)
  Hamamoto J, Yasuda H, Aizawa K, Nishino M, Nukaga S, Hirano T, Kawada I, Naoki　K, Betsuyaku T, Soejima K.
- Journal Title
  
  Oncol Lett.
  
  Volume: 14(3) Issue: 3 Pages: 3559-3565
- DOI
  10.3892/ol.2017.6591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-15K09229
[Journal Article] Activation of EGFR Bypass Signaling by TGFα Overexpression Induces Acquired Resistance to Alectinib2016
- Author(s)
  Tani T, Yasuda H, Hamamoto J, Kuroda A, Arai D, Ishioka K, Ohgino K, Miyawaki M,, Kawada I, Naoki K, Hayashi Y, Betsuyaku T, Soejima K
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 15(1) Issue: 1 Pages: 162-71
- DOI
  10.1158/1535-7163.mct-15-0084
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14398
[Journal Article] Activation of EGFR bypass signaling by TGFα overexpression induces acquired resistance to alectinib in ALK-translocated lung cancer cells2016
- Author(s)
  Tani T, Yasuda H, Hamamoto J, Kuroda A, Arai D, Ishioka K, Ohgino K, Miyawaki M, Kawada I, Naoki K, Hayashi Y, Betsuyaku T, Soejima K
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 15 Pages: 162-71
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09229
[Journal Article] In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer2016
- Author(s)
  Hirano T, Yasuda H, Tani T, Hamamoto J, Oashi A, Ishioka K, Arai D, Nukaga S, Miyawaki M, Kawada I, Naoki K, Costa DB, Kobayashi SS, BetsuyakuT, Soejima K
- Journal Title
  
  Oncotarget
  
  Volume: 17 Issue: 36 Pages: 38789-803
- DOI
  10.18632/oncotarget.5887
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229, KAKENHI-PROJECT-15K14398, KAKENHI-PROJECT-15H05666
[Journal Article] Activation of EGFR baypass Signaling by TGFα Overexpression Induces Acquired Resistance to Alectinib in ALK-Translocated Lung Cancer Cells2016
- Author(s)
  Tani T, Yasuda H, Hamamoto J, Kuroda A, Arai D, Ishioka K, Ohgino K, Miyawaki et al.
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 15(1) Pages: 162-71
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05666
[Journal Article] A phase II study of biweekly paclitaxel and carboplatin in elderly patients with advanced non-small cell lung cancer.2015
- Author(s)
  Soejima K, Naoki K, Ishioka K, Nakamura M, Nakatani R, Kawada I, Watanabe H, Nakachi I, Yasuda H, Satomi R, Nakayama S, Yoda S, Ikemura S, Terai H, Sato T, Ohgino K, Arai D and Betsuyaku T
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 75 Issue: 3 Pages: 513-9
- DOI
  10.1007/s00280-014-2673-8
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09229
[Journal Article] Mimicking the niche of lung epithelial stem cells and characterization of several effectors of their in vitro behavior2015
- Author(s)
  Hegab AE, Arai D, Gao J, Kuroda A, Yasuda H, Ishii M, Naoki K, Soejima K, Betsuyaku T
- Journal Title
  
  Stem Cell Res
  
  Volume: 15 Issue: 1 Pages: 109-121
- DOI
  10.1016/j.scr.2015.05.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09229, KAKENHI-PROJECT-15K15323, KAKENHI-PROJECT-15H04833
[Journal Article] Multiple roles of extracellular　fibroblast growth factors in lung cancer cells2015
- Author(s)
  Suzuki T, Yasuda H, Funaishi K, Arai D, Ishioka K, Ohgino K, Tani T, Hamamoto J, Ohashi A, Naoki K, Betsuyaku T, Soejima K
- Journal Title
  
  Int J Oncol
  
  Volume: 46 Issue: 1 Pages: 423-429
- DOI
  10.3892/ijo.2014.2718
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390218, KAKENHI-PROJECT-25860656, KAKENHI-PROJECT-15H04833
[Journal Article] Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer2015
- Author(s)
  Sato T, Soejima K, Arai E, Hamamoto J, Yasuda H, Arai D, Ishioka K, Ohgino K, Naoki K, Kohno T, Tsuta K, Watanabe S, Kanai Y and Betsuyaku T
- Journal Title
  
  Oncol Rep
  
  Volume: 34 Issue: 3 Pages: 1137-45
- DOI
  10.3892/or.2015.4082
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09229, KAKENHI-PROJECT-15H04833, KAKENHI-PROJECT-26870569
[Journal Article] A phase II study of S-1 and irinotecan combination therapy in previously treated patients with advanced non-small cell lung cancer2015
- Author(s)
  Ikemura S, Naoki K, Yasuda H, Kawada I, Yoda S, Terai H, Sato T, Ishioka K, Arai D, Ohgino K, Kamata H, Miyata J, Kabata H, Betsuyaku T and Soejima K
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 45 Issue: 4 Pages: 356-61
- DOI
  10.1093/jjco/hyu226
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09229
[Journal Article] Characterization of the cell of origin　and propagation potential of the fibroblast growth factor 9-induced mouse model　of lung adenocarcinoma2014
- Author(s)
  Arai D, Hegab AE, Soejima K, Kuroda A, Ishioka K, Yasuda H, Naoki K, KagawaS, Hamamoto J, Yin Y, Ornitz DM, Betsuyaku T S,
- Journal Title
  
  J Pathol
  
  Volume: 235 Issue: 4 Pages: 593-605
- DOI
  10.1002/path.4486
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390218, KAKENHI-PROJECT-15K09229, KAKENHI-PROJECT-15H04833
[Journal Article] Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer2013
- Author(s)
  Yasuda H, Park E, Yun CH, Sng NJ, Lucena-Araujo AR, Yeo WL, Huberman MS, Cohen DW, Nakayama S, Ishioka K, Yamaguchi N, Hanna M, Oxnard GR, Lathan CS, Moran T, Sequist LV, Chaft JE, Riely GJ, Arcila ME, Soo RA, Meyerson M, Eck MJ, Kobayashi SS, Costa DB
- Journal Title
  
  Ｓｃｉｅｎｃｅ　Ｔｒａｎｓｌａｔｉｏｎａｌ　Ｍｅｄｉｃｉｎｅ
  
  Volume: 18;5(216) Issue: 216 Pages: 1-10
- DOI
  10.1126/scitranslmed.3007205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860656
[Presentation] 肺がんオルガノイド研究による新しいがん治療戦略2024
- Author(s)
  安田　浩之
- Organizer
  日本がん分子標的治療学会第19回トランスレーショナルリサーチワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-21H02765
[Presentation] Understanding lung cancer heterogeneity using patient-derived organoids2023
- Author(s)
  Hiroyuki Yasuda
- Organizer
  Sapporo International Cancer Symposium 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02765
[Presentation] 治療誘導型神経内分泌癌（肺癌）の治療と展望2023
- Author(s)
  安田　浩之
- Organizer
  第61回　日本癌治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02765
[Presentation] 患者由来肺癌オルガノイドを用いた小細胞肺癌の分子学的・生物学的統合解析による治療標的の推定2023
- Author(s)
  福島貴大、安田浩之、浜本純子、江本桂、岡田真彦、齋藤彩夏、高岡初誉、伊藤史麿、茂松梨咲、扇野圭子、寺井秀樹、川田一郎、朝倉啓介、菱田智之、淺村尚生、副島研造、福永興壱
- Organizer
  肺癌学会
- Data Source
  KAKENHI-PROJECT-22K08290
[Presentation] Phase I/II study of osimertinib in EGFR exon 20 insertion mutations in non-small cell lung cancer patients: AEX20.2021
- Author(s)
  Eiki Ichihara, Hiroyuki Yasuda, Jun Sakakibara, Yoshitaka Zenke, Shinji Takeuchi, Masahiro Morise, Katuyuki Kiura, Katsuyuki Hotta, Seiji Yano, Akihiro Nishiyama, Reiko Matsuzawa, Hideki Terai, Shinnosuke Ikemura , Koichi Goto, Kenzo Soejima.
- Organizer
  American Association of Cancer Recearch Annual Meeting,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03671
[Presentation] The influence of intermittent smoking exposure for the lung tumorigenesis in the murine model2018
- Author(s)
  Naofumi Kameyama1, Shotaro Chubachi1, Hidehiro Irie1, Akihiro Tsutsumi1, Hiroyuki Yasuda1, Ichiro Kawada1, Ahmed Hegab1, Masahiro Shimoda2, Tomoko Betsuyaku1
- Organizer
  American Thoracic Soceity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04833
[Presentation] 各種EGFR遺伝子変異に対するEGF816の効果.2017
- Author(s)
  増澤啓太、安田浩之、長谷川華子、額賀重成、平野俊之、西野誠、川田一郎、猶木克彦、副島研造、別役智子
- Organizer
  第57回日本呼吸器学会学術総会、東京
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] Evaluation of the distinct effect of anti-angiogenic agents, nintedanib and bevacizumab in lung cancer on metabolism.2017
- Author(s)
  増澤啓太、荒井大輔、安田浩之、長谷川華子、額賀重成、平野俊之、川田一郎、猶木克彦、副島研造、別役智子
- Organizer
  第76回日本癌学会学術集会、横浜
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] In vitro characterization of the effect of nazartinib against clinically relevant EGFR mutants.2017
- Author(s)
  Keita Masuzawa, Hiroyuki Yasuda, Junko Hamamoto, Toshiyuki Hirano, Shigenari Nukaga, Hanako Hasegawa, Tetsuo Tani, Ichiro Kawada, Katsuhiko Naoki, Kenzo Soejima, Tomoko Betsuyaku
- Organizer
  107th AACR Annual Meeting, Washington DC
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] 実臨床での進行非小細胞肺癌142例に対するニボルマブの効果（多施設共同症例集積研究）2017
- Author(s)
  小林慧悟、猶木克彦、西野誠、谷哲夫、扇野圭子、浅見貴弘、里見良輔、安田浩之、川田一郎、仲地一郎、黄英文、舘野博喜、井上卓、西尾和三、中村守男、小山田吉孝、坂巻文雄、佐山宏一、副島研造、別役智子
- Organizer
  第57回日本呼吸器学会学術総会、東京
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] 当院におけるEGFR 遺伝子変異陽性非小細胞肺癌に対する re-biopsy の検討.2017
- Author(s)
  増澤啓太、安田浩之、小林慧悟、眞鍋維志、長谷川華子、平野俊之、額賀重成、西野誠、川田一郎、猶木克彦、副島研造、別役智子
- Organizer
  第40回日本呼吸器内視鏡学会学術集会、長崎
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] 進行非小細胞肺癌EGFR-TKI治療後再生検での組織およびliquid biopsyによるEGFR T790M検出2017
- Author(s)
  眞鍋維志、小林慧悟、猶木克彦、長谷川華子、増澤啓太、平野俊之、額賀重成、西野誠、安田浩之、川田一郎、副島研造、別役智子
- Organizer
  第57回日本呼吸器学会学術総会、東京
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] EGFR wild type allele amplification induces acquired resistance to mutation-specific EGFR tyrosine kinase inhibitors in non-small cell lung cancer cells.2017
- Author(s)
  Keigo Kobayashi, Shigenari Nukaga, Hiroyuki Yasuda, Keita Masuzawa, Jyunko Hamamoto, Ichiro Kawada, Katsuhiko Naoki, Sachiyo Mimaki, Shingo Matsumoto, Koichi Goto, Katsuya Tsuchihara, Tomoko Betsuyaku, Kenzo Soejima
- Organizer
  107th AACR Annual Meeting, Washington DC
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] 高濃度酸素が肺癌の増殖に与える影響とその分子メカニズム2017
- Author(s)
  浜本純子，副島研造，安田浩之，仲地一郎，長谷川華子，増澤啓太，小林慧悟, 眞鍋維志，川田一郎，猶木克彦，別役智子
- Organizer
  第58回日本肺癌学会総会、横浜
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] Practical effectiveness and safety of Nivolumab on advanced non-small cell lung cancer: a multi center analysis.2017
- Author(s)
  Keigo Kobayashi, Ichiro Nakachi, Katsuhiko Naoki, Yoshitaka Oyamada, Morio Nakamura, Takashi Inoue, Hiroki Tateno, Fumio Sakamaki, Koichi Sayama, Tsuyoshi Terashima, Hidefumi Koh, Makoto Nishino, Daisuke Arai, Hiroyuki Yasuda, Ichiro Kawada, Kenzo Soejima, Tomoko Betsuyaku
- Organizer
  ESMO 2017 Congress, Madrid
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] Evaluation of multiple EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants using in vitro modeling.2016
- Author(s)
  Hanako Hasegawa, Hiroyuki Yasuda, Toshiyuki Hirano, Tetsuo Tani, Junko Yamamoto, Ayano Oashi, Ichiro Kawada, Katsuhiko Naoki, Daniel B. Costa, Susumu S. Kobayashi, Tomoko Betsuyaku, Kenzo Soejima
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] Visualizing the distribution of metabolites and the efficacy of BIBF1120 on metabolic status of lung cancer derived tumors by imaging mass-spectrometry (MS)2016
- Author(s)
  Daisuke Arai, Hiroyuki Yasuda, Kenzo Soejima, Shizuko Kagawa, Junko Hamamoto, Shigenari Nukaga1, Katsuhiko Naoki, Katsura Emoto, Yuki Sugiura, Makoto Suematsu, Tomoko Betsuyaku
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] 高濃度酸素が肺癌の増殖に与える影響とその分子メカニズム2016
- Author(s)
  浜本純子，副島研造，安田浩之，仲地一郎，長谷川華子，増澤啓太，小林慧悟,　眞鍋維志，川田一郎，猶木克彦，別役智子
- Organizer
  日本肺癌学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] Activation of EGFR bypass signaling through TGFα overexpression induces acquired resistance to alectinib in ALK-translocated lung cancer cells2015
- Author(s)
  Tetsuo Tani, Hiroyuki Yasuda, Junko Hamamoto, Aoi Kuroda, Daisuke Arai, Kota Ishioka, Keiko Ohgino, Ichiro Kawada, Katsuhiko Naoki, Hayashi Yuichiro, Tomoko Betsuyaku, Kenzo Soejima
- Organizer
  AACR Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] ABT-263 is effective in a subset of non-small cell lung cancer cell lines2015
- Author(s)
  Aoi Kuroda, Keiko Ohgino, Hiroyuki Yasuda, Junko Hamamoto, Daisuke Arai, Kota Ishioka, Tetsuo Tani, Shigenari Nukaga, Ichiro Kawada, Katsuhiko Naoki, Kenzo Soejima, Tomoko Betsuyaku
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] Hyperoxia may be a treatment option for NSCLC2015
- Author(s)
  Junko Hamamoto, Hiroyuki Yasuda, Ichiro Nakachi, Michael G. Edwards, Masayoshi Miyawaki, Makoto Nishino, Aoi Kuroda, Tetsuo Tani, Daisuke Arai, Kota Ishioka, Ichiro Kawada, Katsuhiko Naoki, Tomoko Betsuyaku, Kenzo Soejima
- Organizer
  AACR Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] PTPRH Hypomethylation as a Prognostic Factor in Non-Small Cell Lung Cancer2015
- Author(s)
  Takashi Sato, Kenzo Soejima, Eri Arai, Junko Hamamoto, Hiroyuki Yasuda, Daisuke Arai, Kota Ishioka, Keiko Ohgino, Katsuhiko Naoki, Takashi Kohno, Koji Tsuta, Shun-Ichi Watanabe, Yae Kanai, Tomoko Betsuyaku
- Organizer
  16TH WORLD CONFERENCE ON LUNG CANCER
- Place of Presentation
  Denver, USA
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] Oncogenic potential of FGF9 in lung cancer2015
- Author(s)
  Kota Ishioka, Kenzo Sejima, Hiroyuki Yasuda, Junko Hamamoto, Ahmed Hegab, Tetsuo Tani, Aoi Kuroda, Daisuke Arai, Keiko Ohgino, Takashi Sato, Terai Hideki, Ichiro Kawada, Katsuhiko Naoki, Yuichiro Hayashi, Tomoko Betsuyaku
- Organizer
  AACR Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] Visualizing the effect of BIBF1120 in lung cancer cells by imaging-massspectrometry (MS)2015
- Author(s)
  Daisuke Arai, Kenzo Soejima, Hiroyuki Yasuda, Kota Ishioka, Shizuko Kagawa, Junko Hamamoto, Katsuhiko Naoki, Katsura Emoto, Yuki Sugiura, Makoto Suematsu, Tomoko Betsuyaku
- Organizer
  AACR Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09229
[Presentation] Clinical, structural and biochemical characterization of EGFR exon 20 insertion mutations in non-small-cell lung cancer (NSCLC).2014
- Author(s)
  Hiroyuki Yasuda, Kenzo Soejima, Kota Ishioka, Katsuhiko Naoki, Tomoko Betsuyaku, Susumu Kobayashi, Daniel B. Costa.
- Organizer
  第54回日本呼吸器学会総会
- Place of Presentation
  大阪
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-25860656

1. Hamamoto Junko (40570239)

# of Collaborated Projects: 7 results

# of Collaborated Products: 20 results
2. Soejima Kenzo (30236145)

# of Collaborated Projects: 4 results

# of Collaborated Products: 37 results
3. HISHIKI Takako (10338022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 別役智子 (60333605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. ヒガブ中井アハマド (00507915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小坂威雄 (30445407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 植田幸嗣 (10509110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 安水洋太 (40464854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 西原広史 (50322805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 渡辺貴志 (50406815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 北野滋久 (60402682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 扇野圭子 (40573324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 藤井正幸 (00867575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 池村辰之介 (30445291)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中山タラントロバート (00365298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 森智章 (30464853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HIZAWA Nobuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. SAKAMOTO Tohru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. FUJISAWA Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. KOMATSU Hiroko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. YAGASAKI Kaori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. HAMAMOTO Yasuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. MASUDA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 戸ヶ崎和博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 阿部貴行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 増澤啓太

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
27. 菱田智之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. HEGAB Ahmed

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Yasuda Hiroyuki 安田 浩之

YASUDA Hiroyuki 安田 浩之

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治療抵抗性肺癌オルガノイドライブラリーを用いた獲得耐性機構の本態解明Principal Investigator

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酸素を用いた癌治療法の開発Principal Investigator

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Clarification of signal pathway dependency of lung cancer using lung cancer organoid libraryPrincipal Investigator

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Development of translational research system to overcome refractory or rare lung cancerPrincipal Investigator

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Clinical application of Imaging Mass-spectrometry in cancer fileldPrincipal Investigator

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Yasuda Hiroyuki 安田浩之

YASUDA Hiroyuki 安田浩之