Doi Tomomitsu 土井知光

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DOI Tomomitsu 土井知光

土井知光ドイトモミツ

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Researcher Number	70437218
Other IDs
Affiliation (Current)	2025: 産業医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 産業医科大学, 医学部, 講師 2017 – 2019: 産業医科大学, 医学部, 講師 2011: 東京大学, 医科学研究所, 特任研究員 2009: 慶應大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Tumor biology and related fields / Gastroenterology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator ICG-001 / βーカテニン / WNTシグナル / 組織幹細胞 / βーcatenin / 消化管上皮幹細胞 / タンパク質間相互作用 / CBP / p300 / βカテニン … More / 幹細胞 / 免疫学 / 腫瘍免疫 / ゲノムワイドスクリーニング / CRISPR/Cas9 / 免疫チェックポイント / 消化管炎症 … More Except Principal Investigator 癌 / ゲノム / 抗体 / 免役学 / マイクロアレイ法 / 免疫沈降法 / ウラシルDNAグリコシラーゼ / RNA編集 / 体細胞突然変異 / クラススイッチ Less

Diversity of the canonical WNT signaling pathway in gastrointestinal epithelial stem cellsPrincipal Investigator
- Principal Investigator
  
  Doi Tomomitsu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Genome-wide screening for genes involved in immune escapePrincipal Investigator
- Principal Investigator
  
  DOI Tomomitsu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  University of Occupational and Environmental Health, Japan
消化管炎症におけるDNA損傷の役割の解析Principal Investigator
- Principal Investigator
  
  土井知光
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
AID-dependent genetic alteration mechanism to generate antigen-specific antibodies
- Principal Investigator
  
  HONJO Tasuku
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2019 2018 2009

All Journal Article Presentation

[Journal Article] Caspase-4 has a role in cell division in epithelial cells through actin depolymerization2024
- Author(s)
  Sumida K, Doi T, Obayashi K, Chiba Y, Nagasaka S, Ogino N, Miyagawa K, Baba R, Morimoto H, Hara H, Terabayashi T, Ishizaki T, Harada M, Endo M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 695 Pages: 149394-149394
- DOI
  10.1016/j.bbrc.2023.149394
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18121, KAKENHI-PROJECT-22K08296, KAKENHI-PROJECT-22K08384, KAKENHI-PROJECT-23K07641, KAKENHI-PROJECT-21K07926, KAKENHI-PROJECT-21K07927, KAKENHI-PROJECT-21K07972, KAKENHI-PROJECT-21K08017, KAKENHI-PROJECT-18K15766, KAKENHI-PROJECT-23K27403
[Journal Article] ANGPTL8 links inflammation and poor differentiation, which are characteristics of malignant renal cell carcinoma2023
- Author(s)
  Takuo Matsukawa , Tomomitsu Doi , Kunie Obayashi , Kazuhiro Sumida , Naohiro Fujimoto , Motoyoshi Endo
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 4 Pages: 1410-1422
- DOI
  10.1111/cas.15700
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07972, KAKENHI-PROJECT-22K08296, KAKENHI-PROJECT-20K08530
[Journal Article] Involvement of activator protein-1 family members in β-catenin and p300 association on the genome of PANC-1 cells2022
- Author(s)
  Doi Tomomitsu、Hojo Hironori、Ohba Shinsuke、Obayashi Kunie、Endo Motoyoshi、Ishizaki Toshimasa、Katoh Akira、Kouji Hiroyuki
- Journal Title
  
  Heliyon
  
  Volume: 8 Issue: 2 Pages: e08890-e08890
- DOI
  10.1016/j.heliyon.2022.e08890
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04952, KAKENHI-PROJECT-20H03885, KAKENHI-PROJECT-21K07972, KAKENHI-PROJECT-21K19589, KAKENHI-PROJECT-21K19611, KAKENHI-PROJECT-21K19883, KAKENHI-PROJECT-20K08530
[Journal Article] Soluble PD-L1 with PD-1-binding capacity exists in the plasma of patients with non-small cell lung cancer2018
- Author(s)
  Takeuchi Masahiro、Doi Tomomitsu、Obayashi Kunie、Hirai Ayako、Yoneda Kazue、Tanaka Fumihiro、Iwai Yoshiko
- Journal Title
  
  Immunology letters
  
  Volume: 196 Pages: 155-160
- DOI
  10.1016/j.imlet.2018.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19617, KAKENHI-PROJECT-16H01747
[Journal Article] The C-terminal region of AID is responsible for a novel function other than DNA cleavage in class switch recombination.2009
- Author(s)
  Doi, M., et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 2758-2763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] The C-terminal region of AID is responsible for a novel function other than DNA cleavage in class switch recombination.2009
- Author(s)
  Doi, T., Kato, L., Ito, S., Shinkura, R., Wei, M., Nagaoka, H., Wang, J., Honjo, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 2758-2763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Carboxy-terminal domain of AID required for its mRNA complex formation in vivo.2009
- Author(s)
  Nonaka, T., Doi, T., Toyoshima, T., Muramatsu, M., Honjo, T., Kinoshita, K.
- Journal Title
  
  Natl.Acad.Sci.USA 106
  
  Pages: 2747-2751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.2009
- Author(s)
  Kobayashi, M., Aida, M., Nagaoka, H., Begum, N.A., Kitawaki, Y., Nakata, M., Stanlie, A., Doi, T., Kato, L., Okazaki, I., Shinkura R., Muramatsu, M., Kinoshita, K., Honjo, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 22375-22380
- NAID
  120001749564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Further evidence for involvement of a non-canonical function of uracil DNA glycosylase in class switch recombination.2009
- Author(s)
  Begum, N.A., Stanlie, A., Doi, T., Sasaki, Y., Jin, H.W., Kim, Y.S., Nagaoka, H., Honjo, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 2752-2757
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Presentation] 腫瘍細胞におけるCaspase-4発現誘導機構の解析2023
- Author(s)
  土井知光、千葉要佑、隅田和広、長坂昌平、遠藤元誉
- Organizer
  第４６回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07972
[Presentation] Runx1エンハンサーeR1はマウス気管支上皮において基底細胞様幹細胞を標識する2023
- Author(s)
  土井知光、大林邦衣、千葉要祐、大里元美、遠藤元誉
- Organizer
  第４６回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07972
[Presentation] CASP4 in epithelial cells regulates cell division and cell size through actin depolymerization2023
- Author(s)
  隅田和広、土井知光、大林邦衣、松川卓生、千葉要佑、長坂昌平、小山倫太郎、遠藤元誉
- Organizer
  第４６回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07972
[Presentation] Caspase4 regulates polyploidization of hepatocellular carcinoma cells through cofilin activity2023
- Author(s)
  隅田和広、土井知光、大林邦衣、松川卓生、千葉要佑、長坂昌平、小山倫太郎、遠藤元誉
- Organizer
  第８２回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07972
[Presentation] eR1 active dormant cells represent reserve stem cell function for tissue regeneration in the stomach corpus of mice2023
- Author(s)
  Kazuto Suda, Tomomitsu Doi, Akiko Nambu, Motomi Osato, Atsuyuki Yamatake, Yoshiaki Ito, Motoyoshi Endo
- Organizer
  第４６回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07972
[Presentation] The Possible Role of Inflammatory Caspase and Pyrotosis in the Pathogenesis of Respiratory Disease2022
- Author(s)
  千葉要祐, 遠藤元誉, 土井知光, 大林邦衣 , 矢寺和博
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K07972
[Presentation] Angiopoietin-like protein 8 (ANGPTL8) は淡明細胞型腎癌の未分化状態の維持と腫瘍微小環境形成に関わる2022
- Author(s)
  松川卓生、土井　知光、大林　邦衣、隅田　和広、藤本　直浩、遠藤　元誉
- Organizer
  第32回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-21K07972
[Presentation] 非小細胞肺癌の進展における炎症性カスパーゼの機能解明2022
- Author(s)
  千葉要祐，土井知光，大林邦衣, 松川卓生，隅田和広，加藤香織，遠藤元誉，矢寺和博
- Organizer
  第40回産業医科大学学会
- Data Source
  KAKENHI-PROJECT-21K07972
[Presentation] Angiopoietin-like protein-8(ANGPTL8)は、淡明細胞型腎癌の分化に関与する。2022
- Author(s)
  松川卓生、土井　知光、大林　邦衣、隅田　和広、藤本　直浩、遠藤　元誉
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07972
[Presentation] 肝細胞におけるCaspase4のストレス調整因子としての機能解析2022
- Author(s)
  隅田　和広、土井　知光、大林　邦衣、遠藤　元誉
- Organizer
  第16回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-21K07972
[Presentation] 転写因子AP-1はβカテニンの補助因子CBP及びp300の選択に関与する2021
- Author(s)
  Doi T, Hojo H, Ohba S, Obayashi K, Endo M, Ishizaki T, Katoh A, Kouji H.
- Organizer
  第４４回　日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K07972
[Presentation] 抗体産生細胞の分化促進におけるERストレスの関連解析2021
- Author(s)
  大林　邦衣、土井　知光、遠藤　元誉
- Organizer
  第４４回　日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K07972
[Presentation] 抗体アイソタイプによるERストレス誘導能の違い2019
- Author(s)
  大林　邦衣、土井　知光、遠藤　元誉
- Organizer
  第４２回日本分子生物が学会年会
- Data Source
  KAKENHI-PROJECT-17K19617

1. SHINKURA Reiko (50362471)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. BEGUM Nasim (80362507)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. HONJO Tasuku (80090504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. NISHIKORI Momoko (60378635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAGAOKA Hitoshi (20270647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. CHON Il-Mi (50452339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KOBAYASHI Maki (20400690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 岩井佳子 (90362467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. OHBA Shinsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. HARA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 北條宏徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 新蔵礼子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Doi Tomomitsu 土井 知光

DOI Tomomitsu 土井 知光

土井 知光 ドイ トモミツ

Research Projects

Research Products

Co-Researchers

Diversity of the canonical WNT signaling pathway in gastrointestinal epithelial stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genome-wide screening for genes involved in immune escapePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

消化管炎症におけるDNA損傷の役割の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

AID-dependent genetic alteration mechanism to generate antigen-specific antibodies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Caspase-4 has a role in cell division in epithelial cells through actin depolymerization2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ANGPTL8 links inflammation and poor differentiation, which are characteristics of malignant renal cell carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of activator protein-1 family members in β-catenin and p300 association on the genome of PANC-1 cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Soluble PD-L1 with PD-1-binding capacity exists in the plasma of patients with non-small cell lung cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The C-terminal region of AID is responsible for a novel function other than DNA cleavage in class switch recombination.2009

Author(s)

Journal Title

Data Source

[Journal Article] The C-terminal region of AID is responsible for a novel function other than DNA cleavage in class switch recombination.2009

Author(s)

Journal Title

Data Source

[Journal Article] Carboxy-terminal domain of AID required for its mRNA complex formation in vivo.2009

Author(s)

Journal Title

Data Source

[Journal Article] AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Further evidence for involvement of a non-canonical function of uracil DNA glycosylase in class switch recombination.2009

Author(s)

Journal Title

Data Source

[Presentation] 腫瘍細胞におけるCaspase-4発現誘導機構の解析2023

Author(s)

Organizer

Data Source

[Presentation] Runx1エンハンサーeR1はマウス気管支上皮において基底細胞様幹細胞を標識する2023

Author(s)

Organizer

Data Source

[Presentation] CASP4 in epithelial cells regulates cell division and cell size through actin depolymerization2023

Doi Tomomitsu 土井知光

DOI Tomomitsu 土井知光

土井知光ドイトモミツ