Kabuta Tomohiro 株田智弘

… Alternative Names

KABUTA Tomohiro 株田智弘

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Researcher Number	70535765
Other IDs	https://orcid.org/0000-0002-3058-2596
Affiliation (Current)	2025: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長
Affiliation (based on the past Project Information) *help	2015 – 2024: 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長 2015: 国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長 2013 – 2014: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長 2012: 独立行政法人国立精神, 神経医療センター, 疾病研究第4部.室長 2010 – 2012: 独立行政法人国立精神・神経医療研究センター, 神経研究所・疾病研究第四部, 室長 2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 48040:Medical biochemistry-related / Basic Section 43030:Functional biochemistry-related / Functional biochemistry / General medical chemistry / Neuroscience in general / Neurology Except Principal Investigator Neurochemistry/Neuropharmacology / Neurology
Keywords	Principal Investigator オートファジー / RNautophagy / リソソーム / 細胞内分解 / RNA分解 / DNautophagy / DNA分解 / autophagy / lysosome / 膜透過型オートファジー … More / シャペロン介在性オートファジー / CMA / 蛋白質分解 / LAMP2C / LAMP2 / SIDT2 / lipid droplet / ミクロリポファジー / 脂肪滴 / ミクロオートファジー / lysosomal degradation / neurodegeneration / Autophagy / ポリグルタミン病 / 神経変性疾患 / DUMP / 核酸分解 / タンパク質分解 / RDA / オートファジー系 / ライソゾーム / 細胞内局在 / RNオートファジー / RNA / 選択的分解 / 膜蛋白質 / リピートRNA / C9ORF72 / 選択的オートファジー / TDP-43 / SOD1 / ALS / 神経分子病態学 … More Except Principal Investigator 酸化ストレス / 情動 / 不安 / 核酸 / 脂肪酸 / LAMP2 / 脳機能発達 / スパイン / ユビキチン / 母体 / 生活習慣 / オートファジー / マウス / 高脂肪食 / 脂質 / RNA代謝 / 神経変性 / 前頭側頭葉変性症 / 筋委縮性側索硬化症 / 細胞死 / ストレス顆粒 / TDP-43 / 前頭側頭型認知症 / 筋萎縮性側索硬化症 / 神経変性疾患 / 神経科学 Less

ミクロオートファジーの分子機構と病態との関連性の解明Principal Investigator
- Principal Investigator
  
  株田智弘
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  National Center of Neurology and Psychiatry
Mechanism and regulation of transport-type autophagyPrincipal Investigator
- Principal Investigator
  
  Kabuta Tomohiro
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Center of Neurology and Psychiatry
核酸を分解する膜透過型オートファジーのメカニズムと疾患との関連Principal Investigator
- Principal Investigator
  
  株田智弘
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  National Center of Neurology and Psychiatry
非小胞輸送型オートファジーの分子メカニズムPrincipal Investigator
- Principal Investigator
  
  株田智弘
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Center of Neurology and Psychiatry
Physiological and pathophysiological roles of nonmembrane transport type autophagyPrincipal Investigator
- Principal Investigator
  
  Kabuta Tomohiro
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  National Center of Neurology and Psychiatry
A study to discover a novel type of intracellular degradation systemPrincipal Investigator
- Principal Investigator
  
  Kabuta Tomohiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  National Center of Neurology and Psychiatry
新規オートファジーシステムの分子機序及び病態との関連Principal Investigator
- Principal Investigator
  
  株田智弘
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Center of Neurology and Psychiatry
Regulation of higher brain function by lipid metabolism
- Principal Investigator
  
  Wada Keiji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Center of Neurology and Psychiatry
Analyses of a novel type of autophagyPrincipal Investigator
- Principal Investigator
  
  Kabuta Tomohiro
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neuroscience in general
- Research Institution
  National Center of Neurology and Psychiatry
Investigation of effect of TDP-43 aggregation on translational control
- Principal Investigator
  
  HIGASHI Shinji
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  公益財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research
Toxicity of ALS-linked mutant SOD1 mediated by aberrant protein interactionsPrincipal Investigator
- Principal Investigator
  
  KABUTA Tomohiro
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry

[Book] 医学のあゆみ「オートファジー-分子機構・生物学的意義・疾患との関わりー」2020
- Author(s)
  株田智弘
- Total Pages
  5
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-16H05146
[Book] 医学のあゆみ「オートファジー-分子機構・生物学的意義・疾患との関わりー」2020
- Author(s)
  株田智弘
- Total Pages
  5
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PLANNED-19H05710
[Book] The　オートファジー　研究者たちの集大成が見える最新ビジュアルテキスト2017
- Author(s)
  藤原悠紀，Viorica Raluca Contu，長谷勝徳，株田智弘
- Total Pages
  224
- Publisher
  羊土社
- ISBN
  9784758103657
- Data Source
  KAKENHI-PROJECT-15K14483
[Book] Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging2013
- Author(s)
  Kabuta T, Fujiwara Y, Wada K
- Total Pages
  8
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-24680038
[Book] 生化学2013
- Author(s)
  株田智弘、藤原悠紀、和田圭司
- Total Pages
  10
- Publisher
  日本生化学会
- Data Source
  KAKENHI-PROJECT-24680038
[Journal Article] Expression of RNautophagy/DNautophagy-related genes is regulated under control of an innate immune receptor2024
- Author(s)
  Fujiwara Yuuki、Oroku Kazuki、Zhou Yinping、Takahashi Masayuki、Katayama Taiichi、Wada Keiji、Tsutsumi Nobuyuki、Sato Tetsuo、Kabuta Tomohiro
- Journal Title
  
  RNA Biology
  
  Volume: 21 Issue: 1 Pages: 1-9
- DOI
  10.1080/15476286.2023.2291610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14453, KAKENHI-PLANNED-19H05710
[Journal Article] Nucleic acid uptake occurs independent of lysosomal acidification but dependent on ATP consumption during RNautophagy/DNautophagy2023
- Author(s)
  Contu Viorica Raluca、Sakai Ryohei、Fujiwara Yuuki、Kabuta Chihana、Wada Keiji、Kabuta Tomohiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 644 Pages: 105-111
- DOI
  10.1016/j.bbrc.2022.12.090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J00363, KAKENHI-PROJECT-21K15367, KAKENHI-PLANNED-19H05710
[Journal Article] Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes2020
- Author(s)
  Hase Katsunori、Contu Viorica Raluca、Kabuta Chihana、Sakai Ryohei、Takahashi Masayuki、Kataoka Naoyuki、Hakuno Fumihiko、Takahashi Shin-Ichiro、Fujiwara Yuuki、Wada Keiji、Kabuta Tomohiro
- Journal Title
  
  Autophagy
  
  Volume: NO Issue: 11 Pages: 1-15
- DOI
  10.1080/15548627.2020.1712109
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-17J10610, KAKENHI-PROJECT-17K07124, KAKENHI-PROJECT-16H05146, KAKENHI-PROJECT-18F18384, KAKENHI-PROJECT-20J00363, KAKENHI-PLANNED-19H05710
[Journal Article] Discovery of a protein uptake pathway in lysosomes2020
- Author(s)
  Fujiwara Yuuki、Contu Viorica Raluca、Kabuta Chihana、Ogawa Megumu、Fujita Hiromi、Kikuchi Hisae、Sakai Ryohei、Hase Katsunori、Suzuki Mari、Koyama-Honda Ikuko、Inoue Michio、Oya Yasushi、Inoue Yukiko U.、Inoue Takayoshi、Takahashi Ryosuke、Nishino Ichizo、Wada Keiji、Noguchi Satoru、Kabuta Tomohiro
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2020.08.11.245688
- Open Access
- Data Source
  KAKENHI-PLANNED-19H05710
[Journal Article] 核酸を分解する新規細胞内分解経路の発見とその分子メカニズム2019
- Author(s)
  株田智弘
- Journal Title
  
  日生研たより（NIBS LETTER）
  
  Volume: 65 Pages: 3-7
- Open Access
- Data Source
  KAKENHI-PROJECT-16H05146
[Journal Article] Molecular mechanisms of RNautophagy and DNautophagy2019
- Author(s)
  株田智弘、Contu Viorica Raluca
- Journal Title
  
  生化学
  
  Volume: 91 Issue: 5 Pages: 620-625
- DOI
  10.14952/SEIKAGAKU.2019.910620
- ISSN
  0037-1017
- Year and Date
  2019-10-25
- Language
  Japanese
- Data Source
  KAKENHI-PLANNED-19H05710, KAKENHI-PROJECT-18F18384, KAKENHI-PROJECT-16H05146
[Journal Article] SIDT2 mediates gymnosis, the uptake of naked single-stranded oligonucleotides into living cells2017
- Author(s)
  Takahashi M, Contu VR, Kabuta C, Hase K, Fujiwara Y, Wada K, Kabuta T
- Journal Title
  
  RNA Biology
  
  Volume: 印刷中 Issue: 11 Pages: 1534-1543
- DOI
  10.1080/15476286.2017.1302641
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15J06868, KAKENHI-PROJECT-15K18853, KAKENHI-PUBLICLY-16H01211, KAKENHI-PROJECT-16H05146, KAKENHI-PROJECT-15J06173, KAKENHI-PROJECT-17J09158, KAKENHI-PROJECT-17J10610, KAKENHI-PROJECT-15K14483
[Journal Article] Lysosomal targeting of SIDT2 via multiple YxxΦ motifs is required for SIDT2 function in the process of RNautophagy2017
- Author(s)
  Contu Viorica Raluca、Hase Katsunori、Kozuka-Hata Hiroko、Oyama Masaaki、Fujiwara Yuuki、Kabuta Chihana、Takahashi Masayuki、Hakuno Fumihiko、Takahashi Shin-Ichiro、Wada Keiji、Kabuta Tomohiro
- Journal Title
  
  Journal of Cell Science
  
  Volume: 130 Issue: 17 Pages: 2843-2853
- DOI
  10.1242/jcs.202481
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01211, KAKENHI-PLANNED-16H06578, KAKENHI-PROJECT-16H05146, KAKENHI-PROJECT-15J06173, KAKENHI-PROJECT-15J06868, KAKENHI-PROJECT-17J09158, KAKENHI-PROJECT-17J10610, KAKENHI-PROJECT-15K14483
[Journal Article] Lysosomal degradation of intracellular nucleic acids-multiple autophagic pathways2017
- Author(s)
  Fujiwara Y, Wada K, Kabuta T.
- Journal Title
  
  J Biochem
  
  Volume: 161 Pages: 145-154
- DOI
  10.1093/jb/mvw085
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01211, KAKENHI-PROJECT-16H05146
[Journal Article] Lysosomal membrane protein SIDT2 mediates the direct uptake of DNA by lysosomes2017
- Author(s)
  Aizawa S, Contu VR, Fujiwara Y, Hase K, Kikuchi H, Kabuta C, Wada K, Kabuta T.
- Journal Title
  
  Autophagy
  
  Volume: 13 Issue: 1 Pages: 218-222
- DOI
  10.1080/15548627.2016.1248019
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01211, KAKENHI-PROJECT-15J06173, KAKENHI-PROJECT-15J06868, KAKENHI-PROJECT-17J10610, KAKENHI-PROJECT-16H05146
[Journal Article] Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes2016
- Author(s)
  Shu Aizawa, Yuuki Fujiwara, Viorica Raluca Contu, Katsunori Hase, Masayuki Takahashi, Hisae Kikuchi, Chihana Kabuta, Keiji Wada & Tomohiro Kabuta
- Journal Title
  
  Autophagy
  
  Volume: 12 Issue: 3 Pages: 565-78
- DOI
  10.1080/15548627.2016.1145325
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18853, KAKENHI-PUBLICLY-26111526, KAKENHI-PROJECT-15J06173, KAKENHI-PROJECT-15J06868, KAKENHI-PROJECT-14J08223, KAKENHI-PROJECT-26860203, KAKENHI-PROJECT-24680038
[Journal Article] Maternal high-fat diet leads to persistent synaptic instability in mouse offspring via oxidative stress during lactation.2016
- Author(s)
  Hatanaka Y., Wada K, Kabuta T.
- Journal Title
  
  Neuroche. Int.
  
  Volume: 印刷中 Pages: 99-108
- DOI
  10.1016/j.neuint.2016.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290027
[Journal Article] RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates.2015
- Author(s)
  Hase K, Fujiwara Y, Kikuchi H, Aizawa S, Hakuno F, Takahashi S, Wada K, Kabuta T.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 43 Issue: 13 Pages: 6439-6449
- DOI
  10.1093/nar/gkv579
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-26111526, KAKENHI-PROJECT-15J06868, KAKENHI-PROJECT-14J08223, KAKENHI-PROJECT-24680038
[Journal Article] Property of lysosomal storage disease associated with midbrain pathology in the CNS of LAMP-2-deficient mice2015
- Author(s)
  Furuta A, Kikuchi H, Fujita H, Yamada D, Fujiwara Y, Kabuta T, Nishino I, Wada K, Uchiyama Y
- Journal Title
  
  Am J Pathol
  
  Volume: 巻未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24680038
[Journal Article] Lysosomal-associated membrane protein 2 Isoforms Are Differentially Affected in Early Parkinson's Disease.2015
- Author(s)
  Murphy KE, Gysbers AM, Abbott SK, Spiro AS, Furuta A, Cooper A, Garner B, Kabuta T, Halliday GM
- Journal Title
  
  Mov Disord
  
  Volume: in press Issue: 12 Pages: 1639-1647
- DOI
  10.1002/mds.26141
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24680038, KAKENHI-PUBLICLY-26111526
[Journal Article] Property of lysosomal storage disease associated with midbrain pathology in the CNS of LAMP-2-deficient mice2015
- Author(s)
  Furuta A, Kikuchi H, Fujita H, Yamada D, Fujiwara Y, Kabuta T, Nishino I, Wada K, Uchiyama Y
- Journal Title
  
  Am J Pathol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26111526
[Journal Article] An RNautophagy/DNautophagy receptor, LAMP2C, possesses an arginine-rich motif that mediates RNA/DNA-binding2015
- Author(s)
  Fujiwara Y, Hase K, Wada K, Kabuta T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 460 Issue: 2 Pages: 281-286
- DOI
  10.1016/j.bbrc.2015.03.025
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J08223, KAKENHI-PROJECT-24680038, KAKENHI-PROJECT-25290027, KAKENHI-PUBLICLY-26111526
[Journal Article] Discovery of a novel type of autophagy targeting RNA2013
- Author(s)
  Fujiwara Y, Furuta A, Kikuchi H, Aizawa S, Hatanaka Y, Konya C, Uchida K, Yoshimura A, Tamai Y, Wada K, Kabuta T
- Journal Title
  
  Autophagy
  
  Volume: 9 Issue: 3 Pages: 403-9
- DOI
  10.4161/auto.23002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590244, KAKENHI-PROJECT-24680038, KAKENHI-PUBLICLY-23110527
[Journal Article] Lysosomal storage and advanced senescence in the brain of LAMP-2-deficient Danon disease2013
- Author(s)
  Furuta A, Wakabayashi K, Haratake J, Kikuchi H, Kabuta T, Mori F, Tokonami F, Katsumi Y, Tanioka F, Uchiyama Y, Nishino I, Wada K
- Journal Title
  
  Acta Neuropathol
  
  Volume: 125 Issue: 3 Pages: 459-461
- DOI
  10.1007/s00401-012-1075-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590244, KAKENHI-PROJECT-23659102, KAKENHI-PROJECT-24300131, KAKENHI-PROJECT-24680038
[Journal Article] Ubiquitin C-terminal hydrolase L1 (UCH-L1) act as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation, independent of its hydrolase activity2013
- Author(s)
  Kabuta, T., Mitsui, T., Takahashi, M., Fujiwara, Y., Kabuta, C., Konya, C., Tsuchiya, Y., Hatanaka, Y., Uchida, K., Hohjoh, H., Wada, K
- Journal Title
  
  J. Biol. Chem
  
  Volume: 288 Issue: 18 Pages: 12615-12626
- DOI
  10.1074/jbc.m112.435701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650199, KAKENHI-PROJECT-24390226, KAKENHI-PROJECT-24680038, KAKENHI-PROJECT-25670428, KAKENHI-PROJECT-25871169
[Journal Article] The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation2013
- Author(s)
  Yosuke Yoneyama
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: Volume 33 Issue: 10 Pages: 1991-2003
- DOI
  10.1128/mcb.01394-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07756, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24680038, KAKENHI-PROJECT-25252047
[Journal Article] Direct uptake and degradation of DNA by lysosomes2013
- Author(s)
  Fujiwara Y, Kikuchi H, Aizawa S, Furuta A, Hatanaka Y, Konya C, Uchida K, Wada K, Kabuta T
- Journal Title
  
  Autophagy
  
  Volume: 9 Issue: 8 Pages: 1167-71
- DOI
  10.4161/auto.24880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590244, KAKENHI-PROJECT-24680038, KAKENHI-PROJECT-25290027
[Journal Article] TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress2013
- Author(s)
  Higashi S., Kabuta T., Nagai Y., Tsuchiya Y., Akiyama H., Wada K
- Journal Title
  
  J. Neurochem
  
  Volume: 126(2) Issue: 2 Pages: 288-300
- DOI
  10.1111/jnc.12194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-23791008, KAKENHI-PROJECT-24659438, KAKENHI-PROJECT-24680038, KAKENHI-PUBLICLY-25110741, KAKENHI-PUBLICLY-23110527
[Journal Article] A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.2012
- Author(s)
  Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 32 Issue: 17 Pages: 3585-3593
- DOI
  10.1128/mcb.00455-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24680038
[Journal Article] Localization of MAP1? LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies2011
- Author(s)
  Higashi S, Moore DJ, Minegishi M, Kasanuki K, Fujishiro H, Kabuta T, Togo T, Katsuse 0, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H, Wada K, Iseki E
- Journal Title
  
  J Neuropathol Exp Neurol
  
  Volume: 70 Pages: 264-280
- URL
  http://ovidsp.tx.ovid.com/sp-3.5.1a/ovidweb.cgi?QS2=434f4e1a73d37e8c54b7bccef7797d0edb53f05ad3a4d1c3b26bd796923b86f733e687cf678e4da62d9832a1f418fb666flObb3957c0173d25b9268c1a52clee3d82114fc19965926abca3e829ea7c690748e18d561c00469a9f385a8b938a7a1f44aea94be
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790838
[Journal Article] Parkinson's disease-associated mutations in alpha-synuelein and UCH-L1 inhibit the unconventional secretion of UCH-L12011
- Author(s)
  Konya C, Hatanaka Y, Fujiwara Y, Uchida K, Nagai Y, Wada K, Kabuta T
- Journal Title
  
  Neurochem Int
  
  Volume: 59 Pages: 251-258
- URL
  http://www.sciencedirect.com/science/article/pii/S0197018611001860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790838
[Journal Article] IGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1? induced ERK1/2 activation2010
- Author(s)
  Higashi S, Iseki E, Minegishi M, Togo T, Kabuta T, Wada K
- Journal Title
  
  Neurochem
  
  Volume: 115 Pages: 423-437
- URL
  http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2010.06930.x/abstract;jsessionid=4CF7294F753B1E0F660FE9A227C207FF.d03t035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790838
[Journal Article] Deficiency of ubiquitin carboxy-terminal hydrolase-L1(UCH-L1) leads to vulnerability to lipid peroxidation2010
- Author(s)
  Nagamine S, Kabuta T, Furuta A, Yamamoto K, Takahashi A, Wada K
- Journal Title
  
  Neurochem. Int
  
  Volume: 57 Pages: 102-110
- URL
  http://www.sciencedireet.com/seience/article/pii/S019701861000149X
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790838
[Journal Article] Identification of a novel chemical potentiator and inhibitors of UCH? L1 by in silico drug screening2010
- Author(s)
  Mitsui T, Hirayama K, Aoki S, Nishikawa K, Uchida K, Matsumoto T, Kabuta T, Wada K
- Journal Title
  
  Neurochem. Int
  
  Volume: 56 Pages: 679-686
- URL
  http://www.sciencedireet.com/seience/article/pii/S0197018610000549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790838
[Journal Article] Reduction of abnormal behavioral response to brief restraint by information from other mice in dystrophin? deficient mdx mice2010
- Author(s)
  Yamamoto K, Yamada D, Kabuta T, Takahashi A, Wada K, Sekiguchi M
- Journal Title
  
  Neuromuscul. Disord
  
  Volume: 20 Pages: 505-511
- URL
  http://www.sciencedirect.com/science/article/pii/S0960896610002191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790838
[Journal Article] Insulin receptor substrate-3, interacting with Bel-3, enhances p50 NF? kappaB activity2010
- Author(s)
  Kabuta T, Hakuno F, Cho Y, Yamanaka D, Chida K, Asano T, Wada K, Takahashi S
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 394 Pages: 697-702
- URL
  http://www.sciencedireet.com/seience/article/pii/S0006291X10004924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790838
[Journal Article] TDP-43 Physically Interacts with Amyotrophic Lateral Sclerosis? Linked Mutant CuZn Superoxide Dismutase2010
- Author(s)
  Higashi S, Tsuchiya Y, Araki T, Wada K, Kabuta T
- Journal Title
  
  Neurochem. Int
  
  Volume: 57 Pages: 906-913
- URL
  http://www.sciencedirect.com/science/article/pii/S0197018610003001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790838
[Journal Article] TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress
- Author(s)
  Shinji Higashi, Tomohiro Kabuta, Yoshitaka Nagai, Yukihiro Tsuchiya, Haruhiko Akiyama, Keiji Wada
- Journal Title
  
  J Neurochem
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791008
[Patent] 標的ポリペプチド分解誘導剤2020
- Inventor(s)
  株田智弘、他5名
- Industrial Property Rights Holder
  国立研究開発法人国立精神・神経医療研究センター
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PLANNED-19H05710
[Patent] 異常核酸分解誘導剤2015
- Inventor(s)
  株田智弘, 藤原悠紀, 和田圭司, 相澤修, 長谷勝徳
- Industrial Property Rights Holder
  国立精神・神経医療研究センター
- Industrial Property Rights Type
  特許
- Filing Date
  2015-10-09
- Overseas
- Data Source
  KAKENHI-PROJECT-24680038
[Patent] 異常核酸分解誘導剤2015
- Inventor(s)
  株田智弘, 藤原悠紀, 和田圭司, 相澤修, 長谷勝徳
- Industrial Property Rights Holder
  国立精神・神経医療研究センター
- Industrial Property Rights Type
  特許
- Filing Date
  2015-10-09
- Overseas
- Data Source
  KAKENHI-PUBLICLY-26111526
[Patent] 異常核酸分解誘導剤2014
- Inventor(s)
  株田智弘, 藤原悠紀, 和田圭司, 相澤修, 長谷勝徳
- Industrial Property Rights Holder
  国立精神・神経医療研究センター
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-209340
- Filing Date
  2014-10-10
- Data Source
  KAKENHI-PUBLICLY-26111526
[Patent] 異常核酸分解誘導剤2014
- Inventor(s)
  株田智弘, 藤原悠紀, 和田圭司, 相澤修, 長谷勝徳
- Industrial Property Rights Holder
  国立精神・神経医療研究センター
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-209340
- Filing Date
  2014-10-10
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] リソソームが直接的にタンパク質・核酸を取り込む細胞内分解機構とその役割2024
- Author(s)
  株田智弘
- Organizer
  第2回タンパク質シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-19H05710
[Presentation] RNautophagyの分子メカニズムと役割2023
- Author(s)
  株田智弘
- Organizer
  第67回日本薬学会関東支部大会シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-19H05710
[Presentation] ATP-dependent uptake of proteins by lysosomes2022
- Author(s)
  Tomohiro Kabuta
- Organizer
  The 10th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05710
[Presentation] リソソームによる新しいタンパク質分解機構2020
- Author(s)
  株田智弘
- Organizer
  第93回日本生化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-19H05710
[Presentation] リソソームによる新しいタンパク質分解機構2020
- Author(s)
  株田智弘
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18F18384
[Presentation] 新しい膜透過型オートファジーの分子機構2019
- Author(s)
  株田智弘
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-19H05710
[Presentation] RNautophagy: mediators and mechanisms at the cellular level2019
- Author(s)
  Viorica Raluca Contu, Katsunori Hase, Chihana Kabuta, Yuuki Fujiwara, Keiji Wada, Tomohiro Kabuta.
- Organizer
  The 9th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18F18384
[Presentation] 新しい膜透過型オートファジーの分子機構2019
- Author(s)
  株田智弘
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05146
[Presentation] Effect of lysosomal acidification on RNA translocation across the lysosomal membrane during RNautophagy2019
- Author(s)
  Viorica Raluca Contu, Chihana Kabuta, Katsunori Hase, Yuuki Fujiwara, Keiji Wada, Tomohiro Kabuta
- Organizer
  The 92nd Annual Meeting of the Japanese Biochemical Society
- Data Source
  KAKENHI-PROJECT-18F18384
[Presentation] RNautophagyの細胞内基質2018
- Author(s)
  株田智弘
- Organizer
  第11回オートファジー研究会
- Data Source
  KAKENHI-PROJECT-16H05146
[Presentation] 新しいタイプのオーファジー：発見・メカニズム・生物学的意義・神経疾患治療への応用2018
- Author(s)
  株田智弘
- Organizer
  NCNP-TUAT　若手研究シンポジウム2018夏
- Invited
- Data Source
  KAKENHI-PROJECT-16H05146
[Presentation] 非小胞輸送型オートファジーRNautophagy/DNautophagyの分子メカニズム2017
- Author(s)
  株田智弘
- Organizer
  2017年度生命科学系学会合同年次大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01211
[Presentation] Molecular mechanisms of RNautophagy DNautophagy2017
- Author(s)
  Kabuta T
- Organizer
  KSAP Annual convention 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01211
[Presentation] Molecular mechanisms of RNautophagy DNautophagy2017
- Author(s)
  Kabuta T
- Organizer
  KSAP Annual convention 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05146
[Presentation] 核酸を分解する非小胞輸送型オートファジー　ーその発見と解明への挑戦ー2017
- Author(s)
  株田智弘
- Organizer
  第33回高峰カンファレンス
- Place of Presentation
  東京
- Year and Date
  2017-03-13
- Invited
- Data Source
  KAKENHI-PUBLICLY-16H01211
[Presentation] 核酸を分解する非小胞輸送型オートファジー　ーその発見と解明への挑戦ー2017
- Author(s)
  株田智弘
- Organizer
  第33回高峰カンファレンス
- Place of Presentation
  東京
- Year and Date
  2017-03-13
- Invited
- Data Source
  KAKENHI-PROJECT-16H05146
[Presentation] 非小胞輸送型オートファジーRNautophagy/DNautophagyの分子メカニズム2017
- Author(s)
  株田智弘
- Organizer
  2017年度生命科学系学会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05146
[Presentation] RNautophagy/DNautophagyのメカニズム2015
- Author(s)
  株田智弘
- Organizer
  第67回日本細胞生物学会大会
- Place of Presentation
  タワーホール船堀（東京）
- Year and Date
  2015-06-30
- Invited
- Data Source
  KAKENHI-PUBLICLY-26111526
[Presentation] RNautophagy/DNautophagyのメカニズム2015
- Author(s)
  株田智弘
- Organizer
  第67回日本細胞生物学会大会
- Place of Presentation
  タワーホール船堀（東京）
- Year and Date
  2015-06-30
- Invited
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] Discovery of Novel RNA/DNA degradation systems2014
- Author(s)
  Fujiwara Y, Wada K, Kabuta T
- Organizer
  New Frontier of Molecular Neuropathology 2014
- Place of Presentation
  Tokyo, Tokyo Medical and Dental University, M&D Tower
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] 新たなオートファジーシステムRNautophagyの発見とそのメカニズム2014
- Author(s)
  株田智弘
- Organizer
  大阪大学蛋白質研究所セミナー　オートファジーと疾患
- Place of Presentation
  大阪、大阪大学蛋白質研究所
- Invited
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] 脳におけるRNAを標的とした新規オートファジー経路2013
- Author(s)
  藤原悠紀, 和田圭司, 株田智弘
- Organizer
  Neuro2013
- Place of Presentation
  京都、京都国際会館
- Invited
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] 新規核酸分解システムRNautophagy/DNautophagy2013
- Author(s)
  株田智弘
- Organizer
  第7回オートファジー研究会
- Place of Presentation
  静岡、ヤマハリゾートつま恋カンファレンスセンター
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] 脳におけるRNAを標的とした新規オートファジー経路2013
- Author(s)
  藤原悠紀、和田圭司、株田智弘
- Organizer
  Neuro2013
- Place of Presentation
  京都国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-25290027
[Presentation] Direct Uptake and Degradation of RNA by Lysosomes．2013
- Author(s)
  Fujiwara Y, Wada K, Kabuta T
- Organizer
  Autophagy:molecular mechanism, physiology & pathology
- Place of Presentation
  Hurtigruten MS Trollfjord, Norway
- Data Source
  KAKENHI-PROJECT-25290027
[Presentation] Direct Uptake and Degradation of RNA by Lysosomes2013
- Author(s)
  Fujiwara Y, Wada K, Kabuta T
- Organizer
  EMBO Conference: Autophagy: molecular mechanism, physiology and pathology
- Place of Presentation
  Norway, Hurtigruten MS Trollfjord
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] A Novel Type of Autophagy that Targets RNA. Keystone Symposia on Molecular and Cellular Biology2013
- Author(s)
  Fuji war a Y, Furuta A, Kikuchi H, Aizawa S, Hatanaka Y, Konya C, Uchida K, Wada K, Kabuta T.
- Organizer
  Keystone Symposia on Molecular and Cellular Biology, Autophagy, Inflammation and Immunity
- Place of Presentation
  Fairmont The Queen Elizabeth Montreal, Canada
- Year and Date
  2013-02-18
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] RNAを標的とする新たなオートファジー機構2012
- Author(s)
  藤原悠紀, 古田晶子, 菊地寿枝, 相澤修, 畑中悠佑, 紺谷千穂, 内田健康, 和田圭司, 株田智弘
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場、福岡
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] 筋萎縮性側索硬化症モデルショウジョウバエにおける単量体mutant SOD1の神経毒性2011
- Author(s)
  株田智弘
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜(横浜)(シンポジウム)(招待講演)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22790838
[Presentation] パーキンソン病関連変異型UCH-L1の異常な分子性質2011
- Author(s)
  株田智弘
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  瑠璃光(加賀)(シンポジウム)(招待講演)
- Year and Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-22790838
[Presentation] パーキンソン病関連変異型UCH-L1の異常な分子性質2011
- Author(s)
  株田智弘
- Organizer
  第54回日本神経化学会大会シンポジウム
- Place of Presentation
  加賀
- Year and Date
  2011-09-26
- Data Source
  KAKENHI-PROJECT-22790838
[Presentation] 家族性パーキンソン病変異によるUCH-L1の分泌減少2010
- Author(s)
  紺谷千穂、藤原悠紀、永井義隆、内田健康、和田圭司、株田智弘
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22790838
[Presentation] GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1? induced ERK1/2 activation2010
- Author(s)
  Higashi S, Iseki E, Minegishi M, Togo T, Kabuta T, Wada K
- Organizer
  14th European Federation of Neurological Societies(EFNS) Congress
- Place of Presentation
  Geneva, Switzerland
- Year and Date
  2010-09-26
- Data Source
  KAKENHI-PROJECT-22790838
[Presentation] リソソームにおける新たな核酸分解システム
- Author(s)
  株田智弘
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都、国立京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PUBLICLY-26111526
[Presentation] A Novel Type of autophagy targeting RNA and its possible involvement in Danon disease
- Author(s)
  Kabuta T
- Organizer
  Max Planck Institute & National Center of Neurology and Psychiatry Joint Symposium
- Place of Presentation
  The Prince Hakone, Hakone
- Year and Date
  2014-11-05 – 2014-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] Direct uptake and degradation of RNA/DNA by lysosomes
- Author(s)
  Kabuta T
- Organizer
  The 16th Norteastern Asian Symposium on Autophagy
- Place of Presentation
  The Westin Chosun Busan Hotel, Busan, Republic of Korea
- Year and Date
  2014-12-18 – 2014-12-21
- Invited
- Data Source
  KAKENHI-PUBLICLY-26111526
[Presentation] 精神疾患の病因に関与する物質・因子の解析：テストステロンおよびリソソーム分解との関連性について
- Author(s)
  株田智弘, 畑中悠佑, 和田圭司
- Organizer
  第36回日本生物学的精神医学会・第57回日本神経化学会合同年会
- Place of Presentation
  奈良、奈良県新公会堂
- Year and Date
  2014-09-29 – 2014-10-01
- Invited
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] RNautophagy/DNautophagyの分子メカニズム
- Author(s)
  株田智弘
- Organizer
  第8回オートファジー研究会・文部科学省科学研究費補助金「新学術領域」オートファジーの集学的研究　分子基盤から疾患まで　第2回班会議
- Place of Presentation
  札幌、シャトレーゼ　ガトーキングダム　サッポロ
- Year and Date
  2014-11-09 – 2014-11-11
- Data Source
  KAKENHI-PUBLICLY-26111526
[Presentation] Direct uptake and degradation of RNA/DNA by lysosomes
- Author(s)
  Kabuta T
- Organizer
  The 16th Norteastern Asian Symposium on Autophagy
- Place of Presentation
  The Westin Chosun Busan Hotel, Busan, Republic of Korea
- Year and Date
  2014-12-18 – 2014-12-21
- Invited
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] A Novel Type of autophagy targeting RNA and its possible involvement in Danon disease
- Author(s)
  Kabuta T
- Organizer
  Max Planck Institute & National Center of Neurology and Psychiatry Joint Symposium
- Place of Presentation
  The Prince Hakone, Hakone
- Year and Date
  2014-11-05 – 2014-11-07
- Invited
- Data Source
  KAKENHI-PUBLICLY-26111526
[Presentation] RNautophagy/DNautophagyの分子メカニズム
- Author(s)
  株田智弘
- Organizer
  第8回オートファジー研究会・文部科学省科学研究費補助金「新学術領域」オートファジーの集学的研究　分子基盤から疾患まで　第2回班会議
- Place of Presentation
  札幌、シャトレーゼ　ガトーキングダム　サッポロ
- Year and Date
  2014-11-09 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] リソソームにおける新たな核酸分解システム
- Author(s)
  株田智弘
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都、国立京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-24680038
[Presentation] 精神疾患の病因に関与する物質・因子の解析：テストステロンおよびリソソーム分解との関連性について
- Author(s)
  株田智弘, 畑中悠佑, 和田圭司
- Organizer
  第36回日本生物学的精神医学会・第57回日本神経化学会合同年会
- Place of Presentation
  奈良、奈良県新公会堂
- Year and Date
  2014-09-29 – 2014-10-01
- Invited
- Data Source
  KAKENHI-PUBLICLY-26111526

1. WADA Keiji (70250222)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. HIGASHI Shinji (30365647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. AKIYAMA Haruhiko (20231839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. NAGAI Yoshitaka (60335354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. SEKIGUCHI Masayuki (80260339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. CONTU VIORICA

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. 高橋昌幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 古田晶子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 伯野史彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 高橋伸一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 藤原悠紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kabuta Tomohiro 株田 智弘

KABUTA Tomohiro 株田 智弘

Research Projects

Research Products

Co-Researchers

ミクロオートファジーの分子機構と病態との関連性の解明Principal Investigator

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Mechanism and regulation of transport-type autophagyPrincipal Investigator

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核酸を分解する膜透過型オートファジーのメカニズムと疾患との関連Principal Investigator

Principal Investigator

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非小胞輸送型オートファジーの分子メカニズムPrincipal Investigator

Principal Investigator

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Physiological and pathophysiological roles of nonmembrane transport type autophagyPrincipal Investigator

Principal Investigator

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A study to discover a novel type of intracellular degradation systemPrincipal Investigator

Principal Investigator

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新規オートファジーシステムの分子機序及び病態との関連Principal Investigator

Principal Investigator

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Regulation of higher brain function by lipid metabolism

Principal Investigator

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Analyses of a novel type of autophagyPrincipal Investigator

Principal Investigator

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Investigation of effect of TDP-43 aggregation on translational control

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Toxicity of ALS-linked mutant SOD1 mediated by aberrant protein interactionsPrincipal Investigator

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[Book] 医学のあゆみ「オートファジー-分子機構・生物学的意義・疾患との関わりー」2020

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[Book] 医学のあゆみ「オートファジー-分子機構・生物学的意義・疾患との関わりー」2020

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Kabuta Tomohiro 株田智弘

KABUTA Tomohiro 株田智弘

[Book] The　オートファジー　研究者たちの集大成が見える最新ビジュアルテキスト2017