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Tanaka Toshiaki  田中 俊昭

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TANAKA Toshiaki  田中 俊昭

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Researcher Number 70536987
Other IDs
Affiliation (Current) 2025: 山形大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help 2022 – 2023: 山形大学, 医学部, 客員研究員
2017 – 2021: 山形大学, 医学部, 助教
2011 – 2015: 山形大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 48010:Anatomy-related
Except Principal Investigator
General anatomy (including Histology/Embryology) / General anatomy (including histology/embryology)
Keywords
Principal Investigator
ジアシルグリセロールキナーゼ / DNA修復複合体 / DNA修復タンパク複合体 / DNA二重鎖切断 / DNAダメージ / DNA修復 / 核膜 / zeta型DGK / エキソソーム / リン脂質代謝酵素 … More / Secファミリー / HSP27 / 開口分泌複合体 / 開口分泌 / プロテインフォスファターゼ / 脂質二重膜 / PP2A / Sec6 / 脱リン酸化 / 開口分泌小胞 … More
Except Principal Investigator
p53 / アポトーシス / 脂質代謝酵素 / ストレス応答 / 炎症応答 / がん細胞 / イノシトールリン脂質 / プロテアソーム / 核 / 行動解析 / 細胞・組織 / 脂肪分解酵素 / トリグリセリド / 白色脂肪 / 高脂肪食 / 個体レベル / 細胞応答 / 褐色脂肪細胞 / 脂肪組織リモデリング / 生活習慣病 / エネルギー代謝 / 酵素活性依存的 / NF-kB / 酵素活性 / 転写調節 / ジアシルグリセロールキナーゼ / 脂質代謝 / 運動学習実験 / 小脳 / プルキンエ細胞 / ストレス / カテコールアミン / ステロイド / 副腎 / 免疫電顕 / 小胞体 / 細胞内局在 / リン脂質代謝 / 細胞死 / 海馬ニューロン / 酸素グルコース欠乏 / 細胞組織化学 / 細胞周期 Less
  • Research Projects

    (5 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (7 People)
  •  DNA修復時の「足場」として働く核膜でのリン脂質代謝の機能Principal Investigator

    • Principal Investigator
      田中 俊昭
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48010:Anatomy-related
    • Research Institution
      Yamagata University
  •  Understanding the anchoring disruptor or modulator of subunits of the exocyst provides a new therapeutic strategy for various diseases.Principal Investigator

    • Principal Investigator
      Tanaka Toshiaki
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48010:Anatomy-related
    • Research Institution
      Yamagata University
  •  Life and disease orchestrated by lipid metabolizing enzymes

    • Principal Investigator
      Goto Kaoru
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General anatomy (including histology/embryology)
    • Research Institution
      Yamagata University
  •  Functional roles of the lipid second messenger metabolizing enzyme family

    • Principal Investigator
      Goto Kaoru
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      Yamagata University
  •  Functional role of lipid second messenger metabolizing enzyme in cell cycle and stress response

    • Principal Investigator
      GOTO Kaoru
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      Yamagata University

All 2021 2020 2019 2018 2017 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

  • [Journal Article] Regulation of p53 and NF-κB transactivation activities by DGKζ in catalytic activity-dependent and -independent manners2021

    • Author(s)
      Tanaka Toshiaki、Nakano Tomoyuki、Hozumi Yasukazu、Martelli Alberto M.、Goto Kaoru
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

      Volume: 1868 Issue: 4 Pages: 118953-118953

    • DOI

      10.1016/j.bbamcr.2021.118953

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08508, KAKENHI-PROJECT-20K07238, KAKENHI-PROJECT-17H04012, KAKENHI-PROJECT-18K06815
  • [Journal Article] Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2.2020

    • Author(s)
      Tanaka K, Tanaka T*, Nakano T, Hozumi Y, Yanagida M, Araki Y, Iwazaki K, Takagi M, Goto K
    • Journal Title

      Cellular Signalling

      Volume: 65 Pages: 1-8

    • DOI

      10.1016/j.cellsig.2019.109428

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06815, KAKENHI-PROJECT-16K11111, KAKENHI-PROJECT-17K08507, KAKENHI-PROJECT-18KK0256, KAKENHI-PROJECT-17K19734
  • [Journal Article] DGKζ depletion attenuates HIF-1α induction and SIRT1 expression, but enhances TAK1-mediated AMPKα phosphorylation under hypoxia2020

    • Author(s)
      Akimoto Ryo、Tanaka Toshiaki、Nakano Tomoyuki、Hozumi Yasukazu、Kawamae Kaneyuki、Goto Kaoru
    • Journal Title

      Cellular Signalling

      Volume: 71 Pages: 109618-109618

    • DOI

      10.1016/j.cellsig.2020.109618

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06815, KAKENHI-PROJECT-19K09344, KAKENHI-PROJECT-20K07238
  • [Journal Article] DzMab-1: Anti-Human Diacylglycerol Kinaseζ Monoclonal Antibody for Immunocytochemistry.2019

    • Author(s)
      Nakano T, Ogasawara S, Tanaka T, Hozumi Y, Sano M, Sayama Y, Yamada S, Shirai Y, Kaneko MK, Kato Y, Goto K
    • Journal Title

      Monoclonal antibodies in immunodiagnosis and immunotherapy

      Volume: 38 Issue: 4 Pages: 179-182

    • DOI

      10.1089/mab.2019.0024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06815, KAKENHI-PROJECT-17K08507
  • [Journal Article] Nucleosome assembly proteins NAP1L1 and NAP1L4 modulate p53 acetylation to regulate cell fate.2019

    • Author(s)
      Tanaka T, Hozumi Y, Martelli AM, Iino M, Goto K
    • Journal Title

      BBA Molecular Cell Research

      Volume: 1866 Issue: 12 Pages: 1-13

    • DOI

      10.1016/j.bbamcr.2019.118560

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06815, KAKENHI-PROJECT-19K09344, KAKENHI-PROJECT-17K08507
  • [Journal Article] Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP272018

    • Author(s)
      Tanaka Toshiaki、Iino Mitsuyoshi、Goto Kaoru
    • Journal Title

      Cellular Signalling

      Volume: 49 Pages: 1-16

    • DOI

      10.1016/j.cellsig.2018.04.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06815
  • [Journal Article] DaMab-2: Anti-Human DGKα Monoclonal Antibody for Immunocytochemistry2017

    • Author(s)
      Nakano Tomoyuki、Ogasawara Satoshi、Tanaka Toshiaki、Hozumi Yasukazu、Mizuno Satoru、Satoh Eri、Sakane Fumio、Okada Naoki、Taketomi Akinobu、Honma Ryusuke、Nakamura Takuro、Saidoh Noriko、Yanaka Miyuki、Itai Shunsuke、Handa Saori、Chang Yao-Wen、Yamada Shinji、Kaneko Mika K.、Kato Yukinari、Goto Kaoru
    • Journal Title

      Monoclon. Antib. Immunodiagn. Immunother.

      Volume: 36 Issue: 4 Pages: 181-184

    • DOI

      10.1089/mab.2017.0023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03650, KAKENHI-PROJECT-17H04012
  • [Journal Article] Cellular expression and localization of DGKζ-interacting NAP1-like proteins in the brain and functional implications under hypoxic stress.2014

    • Author(s)
      Takahashi N, Hozumi Y, Tanaka T, Okada M, Iseki K, Hayasaka K, Goto K.
    • Journal Title

      Histochem Cell Biol

      Volume: 142 Issue: 5 Pages: 461-471

    • DOI

      10.1007/s00418-014-1226-x

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390044, KAKENHI-PROJECT-26460266, KAKENHI-PROJECT-26670782, KAKENHI-PROJECT-26830065
  • [Journal Article] Expression of mRNAs for the diacylglycerol kinase family in immune cellsduring an inflammatory reaction2014

    • Author(s)
      Yamamoto M, Tanaka T, Hozumi Y, Saino-Saito S, Nakano T, Tajima K, Kato T, Goto K.
    • Journal Title

      Biomed. Res.

      Volume: 35 Issue: 1 Pages: 61-68

    • DOI

      10.2220/biomedres.35.61

    • NAID

      130004903860

    • ISSN
      0388-6107, 1880-313X
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390044, KAKENHI-PROJECT-24592323
  • [Journal Article] Role of the N-terminal hydrophobic residues of DGKε in targeting the endoplasmic reticulum.2014

    • Author(s)
      Matsui H, Hozumi Y, Tanaka T, Okada M, Nakano T, Suzuki Y, Iseki K, Kakehata S, Topham MK, Goto K.
    • Journal Title

      Biochim Biophys Acta Molecular and Cell Biology of Lipids

      Volume: 1842 Issue: 10 Pages: 1440-1450

    • DOI

      10.1016/j.bbalip.2014.07.007

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390044, KAKENHI-PROJECT-24592729, KAKENHI-PROJECT-26460265, KAKENHI-PROJECT-26460266, KAKENHI-PROJECT-26830065
  • [Journal Article] Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase (JNK)-interacting protein 4 for mitogen-activated protein kinase kinase 4 (MKK4) and suppresses the phosphorylation of MKK4, p38, and JNK, thereby inhibiting apoptosis.2014

    • Author(s)
      Tanaka T, Iino M, Goto K.
    • Journal Title

      FEBS Journal

      Volume: 281 Issue: 23 Pages: 5237-5250

    • DOI

      10.1111/febs.13063

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390044
  • [Journal Article] DGKζ under stress conditions: "To be nuclear or cytoplasmic, that is the question"2014

    • Author(s)
      Goto K, Tanaka T, Nakano T, Okada M, Hozumi Y, Topham MK, Martelli AM.
    • Journal Title

      Advances in Biological Regulation

      Volume: 54 Pages: 242-253

    • DOI

      10.1016/j.jbior.2013.08.007

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390044, KAKENHI-PROJECT-26670782
  • [Journal Article] Cytoplasmic localization of DGKζ exerts a protective effect against p53-mediated cytotoxicity.2013

    • Author(s)
      Tanaka T, Okada M, Hozumi Y, Tachibana K, Kitanaka C, Hamamoto Y, Martelli AM, Topham MK, Iino M, Goto K.
    • Journal Title

      J Cell Sci.

      Volume: 126(Pt 13) Pages: 2785-2797

    • DOI

      10.1242/jcs.118711

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590229, KAKENHI-PROJECT-24390044, KAKENHI-PROJECT-24510085
  • [Journal Article] DGKζ is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry2012

    • Author(s)
      Okada M, Hozumi Y, Tanaka T, Suzuki Y, Yanagida M, Araki Y, Evangelisti C, Yagisawa H, Topham MK, Martelli AM, Goto K.
    • Journal Title

      Cell Signal

      Volume: 24 Issue: 8 Pages: 1573-82

    • DOI

      10.1016/j.cellsig.2012.03.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390050, KAKENHI-PROJECT-22501016, KAKENHI-PROJECT-22659325, KAKENHI-PROJECT-22791745, KAKENHI-PROJECT-24390044
  • [Journal Article] NMDA receptor-mediated Ca(2+) influx triggers nucleocytoplasmic translocation of diacylglycerol kinase ζ under oxygen-glucose deprivation conditions, an in vitro model of ischemia, in rat hippocampal slices2012

    • Author(s)
      Suzuki Y, Yamazaki Y, Hozumi Y, Okada M, Tanaka T, Iseki K, Ohta N, Aoyagi M, Fujii S, Goto K.
    • Journal Title

      Histochem CellBiol

      Volume: 137 Issue: 4 Pages: 499-511

    • DOI

      10.1007/s00418-011-0907-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390050, KAKENHI-PROJECT-21592302, KAKENHI-PROJECT-22500352, KAKENHI-PROJECT-22590235, KAKENHI-PROJECT-22659325, KAKENHI-PROJECT-22791745, KAKENHI-PROJECT-24500434, KAKENHI-PROJECT-24592729
  • [Journal Article] NAP Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins2011

    • Author(s)
      Okada M, Hozumi Y, Ichimura T, Tanaka T, Hasegawa H, Yamamoto M, Takahashi N, Iseki K, Yagisawa H, Shinkawa T, Isobe T, Goto K.
    • Journal Title

      Exp Cell Res

      Volume: 317 Issue: 20 Pages: 2853-63

    • DOI

      10.1016/j.yexcr.2011.09.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390050, KAKENHI-PROJECT-21570213, KAKENHI-PROJECT-22501016, KAKENHI-PROJECT-22659325, KAKENHI-PROJECT-22791745
  • [Presentation] DGKζ deletion dysregulates DNA repair mechanism2020

    • Author(s)
      Toshiaki Tanaka, Kaoru Goto
    • Organizer
      第125回日本解剖学会総会
    • Data Source
      KAKENHI-PROJECT-17H04012
  • [Presentation] DGKζ 結合蛋白NAP1-like proteins によるp21および 細胞周期の制御2014

    • Author(s)
      田中俊昭、後藤薫
    • Organizer
      第119回日本解剖学会総会
    • Place of Presentation
      自治医科大学(栃木)
    • Data Source
      KAKENHI-PROJECT-24390044
  • [Presentation] DGK5結合蛋白NAP1-like proteins による細胞周期制御因子p21を介したサイクリン発現制御機構の解析2013

    • Author(s)
      田中俊昭、後藤薫
    • Organizer
      第118回 日本解剖学会総会
    • Place of Presentation
      香川大学(高松)
    • Data Source
      KAKENHI-PROJECT-24390044
  • [Presentation] Cytoplasmic localization of diacylglycerol kinase ζ exerts a protective effect against p53-mediated cytotoxicity2013

    • Author(s)
      Goto K,Tanaka T
    • Organizer
      44th International Symposium on “Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues”
    • Place of Presentation
      University of Bologna (Italy)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24390044
  • [Presentation] Cytoplasmic localization of diacylglycerol kinase zeta suppresses p53 ind uction after DNA damage.2012

    • Author(s)
      Tanaka T, Goto K
    • Organizer
      42th Annual Meeting of Neuroscience
    • Place of Presentation
      Convention Center(New Orleans, USA)
    • Data Source
      KAKENHI-PROJECT-24390044
  • [Presentation] Cytoplasmic localization of diacylglycerol kinase zeta suppresses p53 induction after DNA damage2012

    • Author(s)
      Tanaka T
    • Organizer
      42th Annual Meeting of Neuroscience
    • Place of Presentation
      Convention Center, New Orleans, USA
    • Data Source
      KAKENHI-PROJECT-20390050
  • [Presentation] Cytoplasmic localization of diacylglycerol kinase zeta suppresses p53 induction after DNA damage2012

    • Author(s)
      Tanaka T, Goto K
    • Organizer
      42th Annual Meeting of Neuroscience, Convention Center
    • Place of Presentation
      New Orleans, USA
    • Data Source
      KAKENHI-PROJECT-20390050
  • [Presentation] Cytoplasmic diacylglycerol kinase ζ suppresses p53 stability and apoptosis2011

    • Author(s)
      Tanaka T, Goto K
    • Organizer
      Gordon Conference, Ventura
    • Place of Presentation
      CA, USA
    • Data Source
      KAKENHI-PROJECT-20390050
  • [Presentation] DNA損傷におけるジアシルグリセロールキナーゼζとp53の役割2010

    • Author(s)
      田中俊昭、後藤薫
    • Organizer
      第115回日本解剖学会総会
    • Place of Presentation
      盛岡
    • Data Source
      KAKENHI-PROJECT-20390050
  • [Presentation] 細胞質局在型ジアシルグリセロールキナーゼζは細胞死を抑制する2010

    • Author(s)
      田中俊昭、後藤薫
    • Organizer
      第56日本解剖学会・東北北海道地方会
    • Place of Presentation
      旭川
    • Data Source
      KAKENHI-PROJECT-20390050
  • [Presentation] 細胞質局在型ジアシルグリゼロールキナーゼζはp53の発現を抑制する2009

    • Author(s)
      田中俊昭、岡田雅司、後藤薫
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-20390050
  • [Presentation] Cytoplasmic lipid kinase suppresses p53 stability.2009

    • Author(s)
      Toshiaki Tanaka, Masashi Okada, Kaoru Goto.
    • Organizer
      39th Annual Meeting of Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-21
    • Data Source
      KAKENHI-PROJECT-20390050
  • [Presentation] Cytoplasmic lipid kinase suppresses p53 stability2009

    • Author(s)
      Toshiaki Tanaka, Masashi Okada, Kaoru Goto
    • Organizer
      39th Annual Meeting of Neuroscience, Convention Center
    • Place of Presentation
      Chicago, USA
    • Data Source
      KAKENHI-PROJECT-20390050
  • [Presentation] Cytoplasmic translocation of DGKzeta exerts a protective effect against p53-mediated cytotoxicity.

    • Author(s)
      Goto K,Tanaka T
    • Organizer
      The American Society for Cell Biology Annual Meeting
    • Place of Presentation
      Philadelphia Convention Center, Philadelphia, USA
    • Year and Date
      2014-12-06 – 2014-12-10
    • Data Source
      KAKENHI-PROJECT-24390044
  • 1.  GOTO Kaoru (30234975)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 21 results
  • 2.  HOZUMI Yasukazu (00372334)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 3.  NAKANO TOMOYUKI (00333948)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 4.  ISEKI Ken (70332921)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  OKADA Masashi (70512614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 6.  FUJII SATOSHI (80173384)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  坂根 郁夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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