Tanaka Toshiaki 田中俊昭

… Alternative Names

TANAKA Toshiaki 田中俊昭

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Researcher Number	70536987
Other IDs
Affiliation (Current)	2025: 山形大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 山形大学, 医学部, 客員研究員 2017 – 2021: 山形大学, 医学部, 助教 2011 – 2015: 山形大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 48010:Anatomy-related Except Principal Investigator General anatomy (including Histology/Embryology) / General anatomy (including histology/embryology)
Keywords	Principal Investigator ジアシルグリセロールキナーゼ / DNA修復複合体 / DNA修復タンパク複合体 / DNA二重鎖切断 / DNAダメージ / DNA修復 / 核膜 / zeta型DGK / エキソソーム / リン脂質代謝酵素 … More / Secファミリー / HSP27 / 開口分泌複合体 / 開口分泌 / プロテインフォスファターゼ / 脂質二重膜 / PP2A / Sec6 / 脱リン酸化 / 開口分泌小胞 … More Except Principal Investigator p53 / アポトーシス / 脂質代謝酵素 / ストレス応答 / 炎症応答 / がん細胞 / イノシトールリン脂質 / プロテアソーム / 核 / 行動解析 / 細胞・組織 / 脂肪分解酵素 / トリグリセリド / 白色脂肪 / 高脂肪食 / 個体レベル / 細胞応答 / 褐色脂肪細胞 / 脂肪組織リモデリング / 生活習慣病 / エネルギー代謝 / 酵素活性依存的 / NF-kB / 酵素活性 / 転写調節 / ジアシルグリセロールキナーゼ / 脂質代謝 / 運動学習実験 / 小脳 / プルキンエ細胞 / ストレス / カテコールアミン / ステロイド / 副腎 / 免疫電顕 / 小胞体 / 細胞内局在 / リン脂質代謝 / 細胞死 / 海馬ニューロン / 酸素グルコース欠乏 / 細胞組織化学 / 細胞周期 Less

DNA修復時の「足場」として働く核膜でのリン脂質代謝の機能Principal Investigator
- Principal Investigator
  
  田中俊昭
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Yamagata University
Understanding the anchoring disruptor or modulator of subunits of the exocyst provides a new therapeutic strategy for various diseases.Principal Investigator
- Principal Investigator
  
  Tanaka Toshiaki
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Yamagata University
Life and disease orchestrated by lipid metabolizing enzymes
- Principal Investigator
  
  Goto Kaoru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Yamagata University
Functional roles of the lipid second messenger metabolizing enzyme family
- Principal Investigator
  
  Goto Kaoru
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Yamagata University
Functional role of lipid second messenger metabolizing enzyme in cell cycle and stress response
- Principal Investigator
  
  GOTO Kaoru
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Yamagata University

All 2021 2020 2019 2018 2017 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Regulation of p53 and NF-κB transactivation activities by DGKζ in catalytic activity-dependent and -independent manners2021
- Author(s)
  Tanaka Toshiaki、Nakano Tomoyuki、Hozumi Yasukazu、Martelli Alberto M.、Goto Kaoru
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1868 Issue: 4 Pages: 118953-118953
- DOI
  10.1016/j.bbamcr.2021.118953
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08508, KAKENHI-PROJECT-20K07238, KAKENHI-PROJECT-17H04012, KAKENHI-PROJECT-18K06815
[Journal Article] Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2.2020
- Author(s)
  Tanaka K, Tanaka T*, Nakano T, Hozumi Y, Yanagida M, Araki Y, Iwazaki K, Takagi M, Goto K
- Journal Title
  
  Cellular Signalling
  
  Volume: 65 Pages: 1-8
- DOI
  10.1016/j.cellsig.2019.109428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06815, KAKENHI-PROJECT-16K11111, KAKENHI-PROJECT-17K08507, KAKENHI-PROJECT-18KK0256, KAKENHI-PROJECT-17K19734
[Journal Article] DGKζ depletion attenuates HIF-1α induction and SIRT1 expression, but enhances TAK1-mediated AMPKα phosphorylation under hypoxia2020
- Author(s)
  Akimoto Ryo、Tanaka Toshiaki、Nakano Tomoyuki、Hozumi Yasukazu、Kawamae Kaneyuki、Goto Kaoru
- Journal Title
  
  Cellular Signalling
  
  Volume: 71 Pages: 109618-109618
- DOI
  10.1016/j.cellsig.2020.109618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06815, KAKENHI-PROJECT-19K09344, KAKENHI-PROJECT-20K07238
[Journal Article] DzMab-1: Anti-Human Diacylglycerol Kinaseζ Monoclonal Antibody for Immunocytochemistry.2019
- Author(s)
  Nakano T, Ogasawara S, Tanaka T, Hozumi Y, Sano M, Sayama Y, Yamada S, Shirai Y, Kaneko MK, Kato Y, Goto K
- Journal Title
  
  Monoclonal antibodies in immunodiagnosis and immunotherapy
  
  Volume: 38 Issue: 4 Pages: 179-182
- DOI
  10.1089/mab.2019.0024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06815, KAKENHI-PROJECT-17K08507
[Journal Article] Nucleosome assembly proteins NAP1L1 and NAP1L4 modulate p53 acetylation to regulate cell fate.2019
- Author(s)
  Tanaka T, Hozumi Y, Martelli AM, Iino M, Goto K
- Journal Title
  
  BBA Molecular Cell Research
  
  Volume: 1866 Issue: 12 Pages: 1-13
- DOI
  10.1016/j.bbamcr.2019.118560
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06815, KAKENHI-PROJECT-19K09344, KAKENHI-PROJECT-17K08507
[Journal Article] Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP272018
- Author(s)
  Tanaka Toshiaki、Iino Mitsuyoshi、Goto Kaoru
- Journal Title
  
  Cellular Signalling
  
  Volume: 49 Pages: 1-16
- DOI
  10.1016/j.cellsig.2018.04.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06815
[Journal Article] DaMab-2: Anti-Human DGKα Monoclonal Antibody for Immunocytochemistry2017
- Author(s)
  Nakano Tomoyuki、Ogasawara Satoshi、Tanaka Toshiaki、Hozumi Yasukazu、Mizuno Satoru、Satoh Eri、Sakane Fumio、Okada Naoki、Taketomi Akinobu、Honma Ryusuke、Nakamura Takuro、Saidoh Noriko、Yanaka Miyuki、Itai Shunsuke、Handa Saori、Chang Yao-Wen、Yamada Shinji、Kaneko Mika K.、Kato Yukinari、Goto Kaoru
- Journal Title
  
  Monoclon. Antib. Immunodiagn. Immunother.
  
  Volume: 36 Issue: 4 Pages: 181-184
- DOI
  10.1089/mab.2017.0023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03650, KAKENHI-PROJECT-17H04012
[Journal Article] Cellular expression and localization of DGKζ-interacting NAP1-like proteins in the brain and functional implications under hypoxic stress.2014
- Author(s)
  Takahashi N, Hozumi Y, Tanaka T, Okada M, Iseki K, Hayasaka K, Goto K.
- Journal Title
  
  Histochem Cell Biol
  
  Volume: 142 Issue: 5 Pages: 461-471
- DOI
  10.1007/s00418-014-1226-x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390044, KAKENHI-PROJECT-26460266, KAKENHI-PROJECT-26670782, KAKENHI-PROJECT-26830065
[Journal Article] Expression of mRNAs for the diacylglycerol kinase family in immune cellsduring an inflammatory reaction2014
- Author(s)
  Yamamoto M, Tanaka T, Hozumi Y, Saino-Saito S, Nakano T, Tajima K, Kato T, Goto K.
- Journal Title
  
  Biomed. Res.
  
  Volume: 35 Issue: 1 Pages: 61-68
- DOI
  10.2220/biomedres.35.61
- NAID
  130004903860
- ISSN
  0388-6107, 1880-313X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390044, KAKENHI-PROJECT-24592323
[Journal Article] Role of the N-terminal hydrophobic residues of DGKε in targeting the endoplasmic reticulum.2014
- Author(s)
  Matsui H, Hozumi Y, Tanaka T, Okada M, Nakano T, Suzuki Y, Iseki K, Kakehata S, Topham MK, Goto K.
- Journal Title
  
  Biochim Biophys Acta Molecular and Cell Biology of Lipids
  
  Volume: 1842 Issue: 10 Pages: 1440-1450
- DOI
  10.1016/j.bbalip.2014.07.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390044, KAKENHI-PROJECT-24592729, KAKENHI-PROJECT-26460265, KAKENHI-PROJECT-26460266, KAKENHI-PROJECT-26830065
[Journal Article] Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase (JNK)-interacting protein 4 for mitogen-activated protein kinase kinase 4 (MKK4) and suppresses the phosphorylation of MKK4, p38, and JNK, thereby inhibiting apoptosis.2014
- Author(s)
  Tanaka T, Iino M, Goto K.
- Journal Title
  
  FEBS Journal
  
  Volume: 281 Issue: 23 Pages: 5237-5250
- DOI
  10.1111/febs.13063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390044
[Journal Article] DGKζ under stress conditions: "To be nuclear or cytoplasmic, that is the question"2014
- Author(s)
  Goto K, Tanaka T, Nakano T, Okada M, Hozumi Y, Topham MK, Martelli AM.
- Journal Title
  
  Advances in Biological Regulation
  
  Volume: 54 Pages: 242-253
- DOI
  10.1016/j.jbior.2013.08.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390044, KAKENHI-PROJECT-26670782
[Journal Article] Cytoplasmic localization of DGKζ exerts a protective effect against p53-mediated cytotoxicity.2013
- Author(s)
  Tanaka T, Okada M, Hozumi Y, Tachibana K, Kitanaka C, Hamamoto Y, Martelli AM, Topham MK, Iino M, Goto K.
- Journal Title
  
  J Cell Sci.
  
  Volume: 126(Pt 13) Pages: 2785-2797
- DOI
  10.1242/jcs.118711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590229, KAKENHI-PROJECT-24390044, KAKENHI-PROJECT-24510085
[Journal Article] DGKζ is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry2012
- Author(s)
  Okada M, Hozumi Y, Tanaka T, Suzuki Y, Yanagida M, Araki Y, Evangelisti C, Yagisawa H, Topham MK, Martelli AM, Goto K.
- Journal Title
  
  Cell Signal
  
  Volume: 24 Issue: 8 Pages: 1573-82
- DOI
  10.1016/j.cellsig.2012.03.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390050, KAKENHI-PROJECT-22501016, KAKENHI-PROJECT-22659325, KAKENHI-PROJECT-22791745, KAKENHI-PROJECT-24390044
[Journal Article] NMDA receptor-mediated Ca(2+) influx triggers nucleocytoplasmic translocation of diacylglycerol kinase ζ under oxygen-glucose deprivation conditions, an in vitro model of ischemia, in rat hippocampal slices2012
- Author(s)
  Suzuki Y, Yamazaki Y, Hozumi Y, Okada M, Tanaka T, Iseki K, Ohta N, Aoyagi M, Fujii S, Goto K.
- Journal Title
  
  Histochem CellBiol
  
  Volume: 137 Issue: 4 Pages: 499-511
- DOI
  10.1007/s00418-011-0907-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390050, KAKENHI-PROJECT-21592302, KAKENHI-PROJECT-22500352, KAKENHI-PROJECT-22590235, KAKENHI-PROJECT-22659325, KAKENHI-PROJECT-22791745, KAKENHI-PROJECT-24500434, KAKENHI-PROJECT-24592729
[Journal Article] NAP Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins2011
- Author(s)
  Okada M, Hozumi Y, Ichimura T, Tanaka T, Hasegawa H, Yamamoto M, Takahashi N, Iseki K, Yagisawa H, Shinkawa T, Isobe T, Goto K.
- Journal Title
  
  Exp Cell Res
  
  Volume: 317 Issue: 20 Pages: 2853-63
- DOI
  10.1016/j.yexcr.2011.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390050, KAKENHI-PROJECT-21570213, KAKENHI-PROJECT-22501016, KAKENHI-PROJECT-22659325, KAKENHI-PROJECT-22791745
[Presentation] DGKζ deletion dysregulates DNA repair mechanism2020
- Author(s)
  Toshiaki Tanaka, Kaoru Goto
- Organizer
  第125回日本解剖学会総会
- Data Source
  KAKENHI-PROJECT-17H04012
[Presentation] DGKζ 結合蛋白NAP1-like proteins によるp21および細胞周期の制御2014
- Author(s)
  田中俊昭、後藤薫
- Organizer
  第119回日本解剖学会総会
- Place of Presentation
  自治医科大学（栃木）
- Data Source
  KAKENHI-PROJECT-24390044
[Presentation] DGK5結合蛋白NAP1-like proteins による細胞周期制御因子p21を介したサイクリン発現制御機構の解析2013
- Author(s)
  田中俊昭、後藤薫
- Organizer
  第118回日本解剖学会総会
- Place of Presentation
  香川大学(高松)
- Data Source
  KAKENHI-PROJECT-24390044
[Presentation] Cytoplasmic localization of diacylglycerol kinase ζ exerts a protective effect against p53-mediated cytotoxicity2013
- Author(s)
  Goto K,Tanaka T
- Organizer
  44th International Symposium on “Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues”
- Place of Presentation
  University of Bologna (Italy)
- Invited
- Data Source
  KAKENHI-PROJECT-24390044
[Presentation] Cytoplasmic localization of diacylglycerol kinase zeta suppresses p53 ind uction after DNA damage.2012
- Author(s)
  Tanaka T, Goto K
- Organizer
  42th Annual Meeting of Neuroscience
- Place of Presentation
  Convention Center(New Orleans, USA)
- Data Source
  KAKENHI-PROJECT-24390044
[Presentation] Cytoplasmic localization of diacylglycerol kinase zeta suppresses p53 induction after DNA damage2012
- Author(s)
  Tanaka T
- Organizer
  42th Annual Meeting of Neuroscience
- Place of Presentation
  Convention Center, New Orleans, USA
- Data Source
  KAKENHI-PROJECT-20390050
[Presentation] Cytoplasmic localization of diacylglycerol kinase zeta suppresses p53 induction after DNA damage2012
- Author(s)
  Tanaka T, Goto K
- Organizer
  42th Annual Meeting of Neuroscience, Convention Center
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-20390050
[Presentation] Cytoplasmic diacylglycerol kinase ζ suppresses p53 stability and apoptosis2011
- Author(s)
  Tanaka T, Goto K
- Organizer
  Gordon Conference, Ventura
- Place of Presentation
  CA, USA
- Data Source
  KAKENHI-PROJECT-20390050
[Presentation] DNA損傷におけるジアシルグリセロールキナーゼζとp53の役割2010
- Author(s)
  田中俊昭、後藤薫
- Organizer
  第115回日本解剖学会総会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-20390050
[Presentation] 細胞質局在型ジアシルグリセロールキナーゼζは細胞死を抑制する2010
- Author(s)
  田中俊昭、後藤薫
- Organizer
  第56日本解剖学会・東北北海道地方会
- Place of Presentation
  旭川
- Data Source
  KAKENHI-PROJECT-20390050
[Presentation] 細胞質局在型ジアシルグリゼロールキナーゼζはp53の発現を抑制する2009
- Author(s)
  田中俊昭、岡田雅司、後藤薫
- Organizer
  第114回日本解剖学会総会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20390050
[Presentation] Cytoplasmic lipid kinase suppresses p53 stability.2009
- Author(s)
  Toshiaki Tanaka, Masashi Okada, Kaoru Goto.
- Organizer
  39th Annual Meeting of Neuroscience
- Place of Presentation
  Chicago, USA
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-20390050
[Presentation] Cytoplasmic lipid kinase suppresses p53 stability2009
- Author(s)
  Toshiaki Tanaka, Masashi Okada, Kaoru Goto
- Organizer
  39th Annual Meeting of Neuroscience, Convention Center
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20390050
[Presentation] Cytoplasmic translocation of DGKzeta exerts a protective effect against p53-mediated cytotoxicity.
- Author(s)
  Goto K,Tanaka T
- Organizer
  The American Society for Cell Biology Annual Meeting
- Place of Presentation
  Philadelphia Convention Center, Philadelphia, USA
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-24390044

1. GOTO Kaoru (30234975)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
2. HOZUMI Yasukazu (00372334)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. NAKANO TOMOYUKI (00333948)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. ISEKI Ken (70332921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. OKADA Masashi (70512614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. FUJII SATOSHI (80173384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 坂根郁夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tanaka Toshiaki 田中 俊昭

TANAKA Toshiaki 田中 俊昭

Research Projects

Research Products

Co-Researchers

DNA修復時の「足場」として働く核膜でのリン脂質代謝の機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the anchoring disruptor or modulator of subunits of the exocyst provides a new therapeutic strategy for various diseases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Life and disease orchestrated by lipid metabolizing enzymes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional roles of the lipid second messenger metabolizing enzyme family

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional role of lipid second messenger metabolizing enzyme in cell cycle and stress response

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Regulation of p53 and NF-κB transactivation activities by DGKζ in catalytic activity-dependent and -independent manners2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DGKζ depletion attenuates HIF-1α induction and SIRT1 expression, but enhances TAK1-mediated AMPKα phosphorylation under hypoxia2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DzMab-1: Anti-Human Diacylglycerol Kinaseζ Monoclonal Antibody for Immunocytochemistry.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nucleosome assembly proteins NAP1L1 and NAP1L4 modulate p53 acetylation to regulate cell fate.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP272018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DaMab-2: Anti-Human DGKα Monoclonal Antibody for Immunocytochemistry2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cellular expression and localization of DGKζ-interacting NAP1-like proteins in the brain and functional implications under hypoxic stress.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of mRNAs for the diacylglycerol kinase family in immune cellsduring an inflammatory reaction2014

Author(s)

Journal Title

DOI

NAID

Tanaka Toshiaki 田中俊昭

TANAKA Toshiaki 田中俊昭

[Presentation] DGKζ 結合蛋白NAP1-like proteins によるp21および細胞周期の制御2014