Fukushima Toshiaki 福嶋俊明

… Alternative Names

TOSHIAKI Fukushima 福嶋俊明

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Researcher Number	70543552
Other IDs
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 東京工業大学, 科学技術創成研究院, 助教 2016: 広島大学, 医歯薬保健学研究院, 助教 2015: 東京工業大学, 生命理工学研究科, 東工大特別研究員 2015: 広島大学, 大学院医歯薬保健学研究院, 助教 2013 – 2014: 広島大学, 医歯薬保健学研究院, 助教 … More 2012: 広島大学, 大学院医歯薬保健学研究院, 助教 2011: 広島大学, 大学院・医歯薬学総合研究科, 助教 2010: 東京大学, 大学院・医歯薬学総合研究科, 助教 2010: The University of Tokyo, 農学生命科学研究科, その他 2009: The University of Tokyo, 大学院・農学生命科学研究科, リサーチフェロー Less
Review Section/Research Field	Principal Investigator Complex systems / General medical chemistry / Applied animal science / Basic Section 42030:Animal life science-related / Metabolomics Except Principal Investigator Metabolomics / Medium-sized Section 42:Veterinary medical science, animal science, and related fields
Keywords	Principal Investigator ユビキチン / 糖尿病 / インスリン受容体基質 / インスリン様成長因子 / インスリン / シグナル伝達 / ケモテクノロジー / クッシング病 / エンドサイトーシス / がん … More / Nedd4 / 脱ユビキチン化酵素 / 体外受精 / PHLDA2 / NRK / 細胞死 / 細胞増殖 / 胎盤 / STAM / メンブレントラフィック / 14-3-3 / USP8 / USP15 / USP / IGF / 国際情報交換　スウェーデン / 細胞内シグナル伝達 / Epsin1 / 細胞内シグナル / 応用動物 / タンパク質 / 核酸 / 発現制御 / 内分泌制御 / 代謝 / 突起仲長 / RNA結合タンパク質 / インスリン受容体基質(IRS) / インスリン様成長因子(IGF) / 局所的翻訳 / RNA制御 … More Except Principal Investigator インスリン / TFG / 糖尿病 / 代謝 / アミノ酸 / インスリン様シグナル / ユビキチン化 / インスリン受容体基質（IRS） / インスリン様成長因子受容体 / がん / 筋分化 / インスリン様活性 / 細胞内シグナル伝達 / インスリン受容体基質 / インスリン様成長因子 / 代謝・内分泌制御 / 糖・脂質代謝 / ＴＦＧ / インスリン分泌 / インスリン抵抗性 / メタボシックシンドローム / LUBAC / 肝細胞 / シグナル伝達 / 肥満 / メタボリックシンドローム / プロリン異性化酵素 / Pin1 Less

胎盤特異的に発現する増殖因子シグナル調節タンパク質による胎盤の発達や機能の制御Principal Investigator
- Principal Investigator
  
  福嶋俊明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Tokyo Institute of Technology
USP8の自己阻害機構の理解に基づく阻害剤開発とクッシング病治療への応用Principal Investigator
- Principal Investigator
  
  福嶋俊明
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Institute of Technology
ケモテクノロジーを活用した脱ユビキチン化酵素USP8の作用機構の解明Principal Investigator
- Principal Investigator
  
  福嶋俊明
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Institute of Technology
Regulatory mechanism of ubiquitin modification of insulin receptor substrates and its physiological and pathological significance.
- Principal Investigator
  
  Takahashi Shin-Ichiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  The University of Tokyo
The regulatory mechanism of IRS monoubiquitination, a vital process regulating insulin/IGF signalingPrincipal Investigator
- Principal Investigator
  
  Fukushima Toshiaki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Institute of Technology
Roles of Pin1 and PAR 14 on the metabolic regulations
- Principal Investigator
  
  Asano Tomoichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Hiroshima University
Roles of Nedd4-IRS complexes in the development of diabetes and cancerPrincipal Investigator
- Principal Investigator
  
  Fukushima Toshiaki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Institute of Technology
  Hiroshima University
Roles of trk-fused gene product protein
- Principal Investigator
  
  Asano Tomoichiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Hiroshima University
Novel regulatory mechanism of insulin activity through IRS monoubiquitinationPrincipal Investigator
- Principal Investigator
  
  FUKUSHIMA Toshiaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Hiroshima University
Physiological roles of ARF1 mRNA interacting with insulin receptor substratesPrincipal Investigator
- Principal Investigator
  
  TOSHIAKI Fukushima
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied animal science
- Research Institution
  Hiroshima University
  The University of Tokyo
mRNAの局所的翻訳制御におけるインスリン受容体基質の新機能解明Principal Investigator
- Principal Investigator
  
  福嶋俊明
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Applied animal science
- Research Institution
  The University of Tokyo

[Book] Progress in Molecular Biology and Translational Science: When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling2016
- Author(s)
  L. Girnita, SI. Takahashi, C. Crudden, T. Fukushima, C. Worrall, H. Furuta, H. Yoshihara, F. Hakuno, A. Girnita
- Publisher
  Elsevier Inc.
- Data Source
  KAKENHI-PROJECT-26460369
[Journal Article] USP8 prevents aberrant NF-kappaB and Nrf2 activation by counteracting ubiquitin signals from endosomes.2024
- Author(s)
  Endo A, Fukushima T, Takahashi C, Tsuchiya H, Ohtake F, Ono S, Ly T, Yoshida Y, Tanaka K, Saeki Y, Komada M.
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 223(3) Issue: 3 Pages: 1-1
- DOI
  10.1083/jcb.202306013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06039, KAKENHI-ORGANIZER-23H04917, KAKENHI-PLANNED-23H04921, KAKENHI-PROJECT-23H05479, KAKENHI-PROJECT-22H00419, KAKENHI-PROJECT-23K23571
[Journal Article] A possible function of <i>Nik-related kinase</i> in the labyrinth layer of delayed delivery mouse placentas2023
- Author(s)
  Hiroshi Yomogita, Hikaru Ito, Kento Hashimoto, Akihiko Kudo, Toshiaki Fukushima, Tsutomu Endo, Yoshikazu Hirate, Yoshihiro Akimoto, Masayuki Komada, Yoshiakira Kanai, Naoyuki Miyasaka, Masami Kanai-Azuma
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 69 Issue: 1 Pages: 32-40
- DOI
  10.1262/jrd.2022-120
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02387, KAKENHI-PROJECT-19K09821, KAKENHI-PROJECT-22K06039, KAKENHI-PROJECT-22K06816, KAKENHI-PROJECT-21K05998, KAKENHI-PROJECT-23K21308
[Journal Article] Dense and Acidic Organelle-Targeted Visualization in Living Cells: Application of Viscosity-Responsive Fluorescence Utilizing Restricted Access to Minimum Energy Conical Intersection2023
- Author(s)
  Adachi Junya、Oda Haruka、Fukushima Toshiaki、Lestari Beni、Kimura Hiroshi、Sugai Hiroka、Shiraki Kentaro、Hamaguchi Rei、Sato Kohei、Kinbara Kazushi
- Journal Title
  
  Analytical Chemistry
  
  Volume: 95 Issue: 12 Pages: 5196-5204
- DOI
  10.1021/acs.analchem.2c04133
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H05872, KAKENHI-PROJECT-22KJ1312, KAKENHI-PROJECT-21K14670, KAKENHI-PLANNED-18H05527, KAKENHI-PUBLICLY-21H00276, KAKENHI-ORGANIZER-18H05418
[Journal Article] Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2-PTEN-AKT Pathway and Placental Cell Proliferation2022
- Author(s)
  Lestari Beni、Naito Satomi、Endo Akinori、Nishihara Hidenori、Kato Akira、Watanabe Erika、Denda Kimitoshi、Komada Masayuki、Fukushima Toshiaki
- Journal Title
  
  Molecular Biology and Evolution
  
  Volume: 39 Issue: 2
- DOI
  10.1093/molbev/msab371
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06039
[Journal Article] Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain2021
- Author(s)
  Kakihara K, Asamizu K, Moritsugu K, Kubo M, Kitaguchi T, Endo A, Kidera A, Ikeguchi M, Kato A, Komada M, Fukushima T
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1272-1272
- DOI
  10.1038/s42003-021-02802-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00276, KAKENHI-PROJECT-23K21308
[Journal Article] 25.Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.2021
- Author(s)
  Beziat V, Rapaport F, Hu J, Titeux M, Bonnet des Claustres M, Bourgey M, Griffin H, Bandet E, Ma CS, Sherkat R, Rokni-Zadeh H, Louis DM, Changi-Ashtiani M, Delmonte OM, Fukushima T, et al.
- Journal Title
  
  Cell
  
  Volume: 184 Issue: 14 Pages: 3812-3828
- DOI
  10.1016/j.cell.2021.06.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00276
[Journal Article] A Novel Amino Acid Signaling Mediated by Ornithine Governs Glucose-6-phosphatase Transcription2021
- Author(s)
  Fukushima S, Nishi H, Kumano M, Yamanaka D, Kataoka N, Hakuno F, Takahashi S-I
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 7 Pages: 102778-102778
- DOI
  10.1016/j.isci.2021.102778
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03972
[Journal Article] コラーゲンの細胞内輸送の分子機構　-脱ユビキチン化酵素USP8による輸送制御-2020
- Author(s)
  福嶋俊明、川口紘平
- Journal Title
  
  FRAGRANCE JOURNAL
  
  Volume: 48 Pages: 10-15
- Data Source
  KAKENHI-PROJECT-17K08625
[Journal Article] Nik‐related kinase is targeted for proteasomal degradation by the chaperone‐dependent ubiquitin ligase CHIP2020
- Author(s)
  Naito Satomi、Fukushima Toshiaki、Endo Akinori、Denda Kimitoshi、Komada Masayuki
- Journal Title
  
  FEBS Letters
  
  Volume: - Issue: 11 Pages: 1778-1786
- DOI
  10.1002/1873-3468.13769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08625, KAKENHI-PUBLICLY-19H05289
[Journal Article] コラーゲンの細胞内輸送の分子機構　-脱ユビキチン化酵素USP8による輸送制御-2020
- Author(s)
  福嶋俊明、川口紘平
- Journal Title
  
  FRAGRANCE JOURNAL
  
  Volume: 48 Pages: 10-15
- Data Source
  KAKENHI-PUBLICLY-19H05289
[Journal Article] The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors2019
- Author(s)
  Sakai R, Fukuda R, Unida S, Aki M, Ono Y, Endo A, Kusumi S, Koga D, Fukushima T, Komada M, Okiyoneda T
- Journal Title
  
  J Cell Sci.
  
  Volume: 132 Issue: 3 Pages: 228007-228007
- DOI
  10.1242/jcs.228007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08458, KAKENHI-PROJECT-17K08625, KAKENHI-PROJECT-15H04293
[Journal Article] RNA-seq of Isolated Chromaffin Cells Highlights the Role of Sex-Linked and Imprinted Genes in Adrenal Medulla Development.2019
- Author(s)
  Chan Wing Hei, Komada Masayuki, Fukushima Toshiaki, Southard-Smith E. Michelle, Anderson Colin R., Wakefield Matthew J.
- Journal Title
  
  Scientific Report
  
  Volume: 9(1) Issue: 1 Pages: 3929-3929
- DOI
  10.1038/s41598-019-40501-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08625, KAKENHI-PROJECT-15H04293
[Journal Article] Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion2018
- Author(s)
  Kawaguchi Kohei、Endo Akinori、Fukushima Toshiaki、Madoka Yuka、Tanaka Toshiaki、Komada Masayuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 499 Issue: 3 Pages: 635-641
- DOI
  10.1016/j.bbrc.2018.03.202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03526, KAKENHI-PROJECT-17K08625, KAKENHI-PROJECT-18K06013, KAKENHI-PROJECT-15H04293
[Journal Article] Nrk’s role in breast cancer2018
- Author(s)
  Denda Kimitoshi, Hayashi Nobuhiro, Fukushima Toshiaki
- Journal Title
  
  Impact
  
  Volume: 2018 Issue: 12 Pages: 76-78
- DOI
  10.21820/23987073.2018.12.76
- Data Source
  KAKENHI-PROJECT-17K08625
[Journal Article] IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line.2018
- Author(s)
  Furuta Haruka, Yoshihara Hidehito, Fukushima Toshiaki, Yoneyama Yosuke, Ito Akihiro, Worrall Claire, Girnita Ada, Girnita Leonard, Yoshida Minoru, Asano Tomoichiro, Komada Masayuki, Kataoka Naoyuki, Chida Kazuhiro, Hakuno Fumihiko, Takahashi Shin-Ichiro
- Journal Title
  
  Oncotarget
  
  Volume: 9(74) Issue: 74 Pages: 33871-33883
- DOI
  10.18632/oncotarget.26049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08625, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-15J10937, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-26221204
[Journal Article] Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities2018
- Author(s)
  Xie Xuan、Matsumoto Shunsuke、Endo Akinori、Fukushima Toshiaki、Kawahara Hiroyuki、Saeki Yasushi、Komada Masayuki
- Journal Title
  
  Journal of Cell Science
  
  Volume: 131 Issue: 8 Pages: 210856-210856
- DOI
  10.1242/jcs.210856
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08625, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-16K14699, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-17H03657
[Journal Article] USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.2017
- Author(s)
  Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 484 Issue: 3 Pages: 522-528
- DOI
  10.1016/j.bbrc.2017.01.101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PLANNED-24112003, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15H04583
[Journal Article] Glucose deprivation attenuates sortilin levels in skeletal muscle cells2017
- Author(s)
  Ariga M, Yoneyama Y, Fukushima T, Ishiuchi Y, Ishii T, Sato H, Hakuno F, Nedachi T, Takahashi S
- Journal Title
  
  Endocr J
  
  Volume: 64 Issue: 3 Pages: 255-268
- DOI
  10.1507/endocrj.EJ16-0319
- NAID
  130005529466
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18766, KAKENHI-PROJECT-16K08077, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15H04583
[Journal Article] USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination2017
- Author(s)
  Fukushima, T., Yoshihara, H., Furuta, H., Hakuno, F., Saeki, Y., Iemura, SI., Natsume, T., Nakatsu, Y., Kamata, H., Asano, T., Komada, M., Takahashi, SI.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 484 Pages: 522-528
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293219
[Journal Article] Reduced SHARPIN and LUBAC Formation May Contribute to CCl4- or Acetaminophen-Induced Liver Cirrhosis in Mice.2017
- Author(s)
  Yamamotoya, T., Nakatsu, Y., Matsunaga, Y., Fukushima, T., Yamazaki, H., Kaneko, S., Fujishiro, M., Kikuchi, T., Kushiyama, A., Tokunaga, F., Asano, T., Sakoda, H.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 18 Pages: 326-326
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293219
[Journal Article] Involvement of Resistin-like molecule beta in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice2016
- Author(s)
  Okubo H., Kushiyama, A., Sakoda, H., Nakatsu, Y., Iizuka, M., Taki, N., Fujishiro, M., Fukushima, T., Kamata, H., Nagamachi, A., Inaba, T., Nishimura, F., Katagiri, H., Asahara, T., Yoshida, Y., Chonan, O., Encinas, J., and Asano, T.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 20157-20157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293219
[Journal Article] Deficiency of X-linked protein kinase Nrk during pregnancy triggers breast tumor in mice2016
- Author(s)
  Yanagawa T, Denda K, Inatani T, Fukushima T, Tanaka T, Kumaki N, Inagaki Y, Komada M
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 186 Issue: 10 Pages: 2751-2760
- DOI
  10.1016/j.ajpath.2016.06.005
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24112003, KAKENHI-PROJECT-15H03526, KAKENHI-PROJECT-15H04293, KAKENHI-PROJECT-25293179, KAKENHI-PROJECT-26440048, KAKENHI-PROJECT-15K15299, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15K14378
[Journal Article] High-molecular-mass complexes containing insulin receptor substrates play important roles in regulation of insulin-like activities.2016
- Author(s)
  Takahashi SI, Fukushima T, Ando Y, Hakuno F.
- Journal Title
  
  Bioscience and Industry
  
  Volume: 74(1)
- NAID
  40020705836
- Data Source
  KAKENHI-PROJECT-26460369
[Journal Article] Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.2016
- Author(s)
  Okubo H, Kushiyama A, Sakoda H, Nakatsu Y, Iizuka M, Taki N, Fujishiro M, Fukushima T, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Asahara T, Yoshida Y, Chonan O, Encinas J, Asano T.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 20157-20157
- DOI
  10.1038/srep20157
- NAID
  120006796541
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-25253067, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26670447, KAKENHI-PROJECT-26860735, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-16H05555, KAKENHI-PROJECT-16K09791
[Journal Article] 甲状腺細胞の増殖誘導機構2016
- Author(s)
  Takahashi SI, Fukushima T, Yamanaka D, Hakuno F.
- Journal Title
  
  甲状腺学会誌
  
  Volume: 7(1)
- Data Source
  KAKENHI-PROJECT-26460369
[Journal Article] When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling2016
- Author(s)
  L Girnita, S-I Takahashi, C Crudden, T Fukushima, C Worrall, H Furuta, H Yoshihara, F Hakuno, A Girnita
- Journal Title
  
  Progress in Molecular Biology and Translational Science
  
  Volume: 141 Pages: 277-311
- DOI
  10.1016/bs.pmbts.2016.04.001
- ISBN
  9780128093863
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-25221204
[Journal Article] DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.2015
- Author(s)
  Shinjo, T., Nakatsu, Y., Iwashita, M., Sano, T., Sakoda, H., Ishihara, H., Kushiyama, A., Fujishiro, M., Fukushima, T., Tsuchiya, Y., Kamata, H., Nishimutra, F., and Asano, T.
- Journal Title
  
  Am. J. Physiol. Endocrinol Metab.
  
  Volume: 309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293219
[Journal Article] Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity2015
- Author(s)
  Fukushima, T., Yoshihara, H., furuta, H., Kamei, H., Hakuno, F., Luan, J., Duan, C., Saeki, Y., Tanaka, K., Iemura, S., Natsume, T., Chida, K., Nakatsu, Y., Kamata, H., Asano, T., and Takahashi, S.
- Journal Title
  
  Nat. Commun.
  
  Volume: 6 Pages: 6780-6780
- NAID
  120006348510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293219
[Journal Article] The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.2015
- Author(s)
  Nakatsu, Y., Seno, Y., Kushiyama, A., Sakoda, H., Fujishiro, M., Katasako, A., Mori, K., Matsunaga, Y., Fukushima, T., Kanaoka, R., Yamamotoya, T., Kamata, H., and Asano, T.
- Journal Title
  
  Am. J. Physiol. Gastrointest Liver Physiol.
  
  Volume: 309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293219
[Journal Article] DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.2015
- Author(s)
  Shinjo, T., Nakatsu, Y., Iwashita, M., Sano, T., Sakoda, H., Ishihara, H., Kushiyama, A., Fujishiro, M., Fukushima, T., Tsuchiya, Y., Kamata, H., Nishimutra, F., and Asano, T.
- Journal Title
  
  Am. J. Physiol. Endocrinol Metab.
  
  Volume: 309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670451
[Journal Article] Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model.2015
- Author(s)
  Hirofumi Okubo, Yusuke Nakatsu, Hideyuki Sakoda, Akifumi Kushiyama, Midori Fujishiro, Toshiaki Fukushima, Yasuka Matsunaga, Haruya Ohno, Masayasu Yoneda, Hideaki Kamata, Takanori Shinjo, Misaki Iwashita, Fusanori Nishimura, and Tomoichiro Asano
- Journal Title
  
  Am. J. Physiol. Gastrointest. Liver Physiol.
  
  Volume: 308 Issue: 2 Pages: 151-158
- DOI
  10.1152/ajpgi.00198.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406
[Journal Article] Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity2015
- Author(s)
  Fukushima, T., Yoshihara, H., furuta, H., Kamei, H., Hakuno, F., Luan, J., Duan, C., Saeki, Y., Tanaka, K., Iemura, S., Natsume, T., Chida, K., Nakatsu, Y., Kamata, H., Asano, T., and Takahashi, S.
- Journal Title
  
  Nat. Commun.
  
  Volume: 6 Pages: 6780-6780
- NAID
  120006348510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670451
[Journal Article] The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.2015
- Author(s)
  Nakatsu Y, Seno Y, Kushiyama A, Sakoda H, Fujishiro M, Katasako A, Mori K, Matsunaga Y, Fukushima T, Kanaoka R, Yamamotoya T, Kamata H, Asano T.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol.
  
  Volume: 309(1) Issue: 1 Pages: G42-G51
- DOI
  10.1152/ajpgi.00443.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-25461372
[Journal Article] The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.2015
- Author(s)
  Nakatsu, Y., Seno, Y., Kushiyama, A., Sakoda, H., Fujishiro, M., Katasako, A., Mori, K., Matsunaga, Y., Fukushima, T., Kanaoka, R., Yamamotoya, T., Kamata, H., and Asano, T.
- Journal Title
  
  Am. J. Physiol. Gastrointest Liver Physiol.
  
  Volume: 308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670451
[Journal Article] Prolyl Isomerase Pin1 Negatively Regulates AMPK by Associating with the CBS Domain in the γ-subunit.2015
- Author(s)
  Nakatsu, Y., Iwashita, M., Sakoda, H., Ono, H., Nagata, K., Matsunaga, Y., Fukushima, T., Fujishiro, M., Kushiyama, A., Kamata, H., Takahashi, S., Katagiri, H., Honda, H., Kiyonari, H., Uchida, T., and Asano, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Pages: 24255-24266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293219
[Journal Article] Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model.2015
- Author(s)
  Okubo, H., Nakatsu, Y., Sakoda, H., Kushiyama, A., Fujishiro, M., Fukushima, T., Matsunaga, Y., Ohno, H., Yoneda, M., Kamata, H., Shinjo, T., Iwashita, M., Nishimura, F., and Asano, T.
- Journal Title
  
  Am. J. Physiol. Gastrointest Liver Physiol.
  
  Volume: 308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670451
[Journal Article] Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines.2015
- Author(s)
  Kanaoka R, Kushiyama A, Seno Y, Nakatsu Y, Matsunaga Y, Fukushima T, Tsuchiya Y, Sakoda H, Fujishiro M, Yamamotoya T, Kamata H, Matsubara A, Asano T.
- Journal Title
  
  PLoS One.
  
  Volume: 10 (6) Issue: 6 Pages: e0127467-e0127467
- DOI
  10.1371/journal.pone.0127467
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10591, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-25461372
[Journal Article] LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.2015
- Author(s)
  Matsunaga, Y., Nakatsu, Y., Fukushima, T., Okubo, H., Iwashita, M., Sakoda, H., Fujishiro, M., Yamamotoya, T., Kushiyama, A., Takahashi, S., Tsuchiya, Y., Kamata, H., Tokunaga, F., Iwai, K., and Asano, T.
- Journal Title
  
  Mediators Inflamm.
  
  Volume: 12 Pages: 125380-125380
- NAID
  120005745641
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293219
[Journal Article] The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins.2015
- Author(s)
  Hakuno F, Fukushima T, Yoneyama Y, Kamei H, Ozoe A, Yoshihara H, Yamanaka D, Shibano T, Sone-Yonezawa M, Yu BC, Chida K, Takahashi S.
- Journal Title
  
  Front Endocrinol (Lausanne).
  
  Volume: 6 Pages: 73-73
- DOI
  10.3389/fendo.2015.00073
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15K18766, KAKENHI-PROJECT-15K18799, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-25221204
[Journal Article] LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.2015
- Author(s)
  Matsunaga, Y., Nakatsu, Y., Fukushima, T., Okubo, H., Iwashita, M., Sakoda, H., Fujishiro, M., Yamamotoya, T., Kushiyama, A., Takahashi, S., Tsuchiya, Y., Kamata, H., Tokunaga, F., Iwai, K., and Asano, T.
- Journal Title
  
  Mediators Inflamm.
  
  Volume: 12 Pages: 125380-125380
- NAID
  120005745641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670451
[Journal Article] Prolyl Isomerase Pin1 Negatively Regulates AMPK by Associating with the CBS Domain in the γ-subunit.2015
- Author(s)
  Nakatsu, Y., Iwashita, M., Sakoda, H., Ono, H., Nagata, K., Matsunaga, Y., Fukushima, T., Fujishiro, M., Kushiyama, A., Kamata, H., Takahashi, S., Katagiri, H., Honda, H., Kiyonari, H., Uchida, T., and Asano, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Pages: 24255-24266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670451
[Journal Article] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF signaling and mitogenic activity.2015
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Jing Luan, Cunming Duan, Yasushi Saeki, Keiji Tanaka, Shun-Ichiro Iemura, TohruNatsume, Kazuhiro Chida, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Journal Title
  
  Nature communications
  
  Volume: 6 Issue: 1 Pages: 6780-6780
- DOI
  10.1038/ncomms7780
- NAID
  120006348510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25850220, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PLANNED-24112008, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-15H04583, KAKENHI-PROJECT-26000014
[Journal Article] LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.2015
- Author(s)
  Matsunaga Y, Nakatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S, Tsuchiya Y, Kamata H, Tokunaga F, Iwai K, Asano T.
- Journal Title
  
  Mediators Inflamm.
  
  Volume: 2015 Issue: 1 Pages: 125380-125380
- DOI
  10.1155/2015/125380
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08259, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26670154, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-25253019
[Journal Article] Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines.2015
- Author(s)
  Kanaoka, R., Kushiyama, A., Seno, Y., Nakatsu, Y., Matsunaga, Y., Fukushima, T., Tsuchiya, Y., Sakoda, H., Fujishiro, M., Yamamotoya, T., Kamata, H., Matsubara, A., and Asano, T.
- Journal Title
  
  PLoS One.
  
  Volume: 10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670451
[Journal Article] Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines.2015
- Author(s)
  Kanaoka, R., Kushiyama, A., Seno, Y., Nakatsu, Y., Matsunaga, Y., Fukushima, T., Tsuchiya, Y., Sakoda, H., Fujishiro, M., Yamamotoya, T., Kamata, H., Matsubara, A., and Asano, T.
- Journal Title
  
  PLoS One.
  
  Volume: 10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293219
[Journal Article] DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.2015
- Author(s)
  Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Asano T.
- Journal Title
  
  Am J Physiol Endocrinol Metab.
  
  Volume: 309(3) Issue: 3 Pages: E214-E223
- DOI
  10.1152/ajpendo.00553.2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15K15351, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-25461372
[Journal Article] Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit2015
- Author(s)
  Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 40 Pages: 24255-24266
- DOI
  10.1074/jbc.m115.658559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09398, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-26660287, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-25253067, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26670447, KAKENHI-PROJECT-26252064, KAKENHI-PROJECT-16H05220
[Journal Article] Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model.2015
- Author(s)
  Okubo, H., Nakatsu, Y., Sakoda, H., Kushiyama, A., Fujishiro, M., Fukushima, T., Matsunaga, Y., Ohno, H., Yoneda, M., Kamata, H., Shinjo, T., Iwashita, M., Nishimura, F., and Asano, T.
- Journal Title
  
  Am. J. Physiol. Gastrointest Liver Physiol.
  
  Volume: 308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293219
[Journal Article] Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis.2014
- Author(s)
  Ozoe A, Sone M, Fukushima T, Kataoka N, Chida K, Asano T, Hakuno F, Takahashi S-I.
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 5 Pages: 24-24
- DOI
  10.3389/fendo.2014.00024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-25660210
[Journal Article] The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease.2014
- Author(s)
  Hashikata, A., Yamashita, A., Suzuki, S., Nagayasu, S., Shinjo, T., Taniguchi, A., Fukushima, M., Nakai, Y., Nin, K., Watanabe, N., Asano, T., Abiko, Y., Kushiyama, A., Nagasaka, S.,and Nishimura, F.
- Journal Title
  
  Nephrol. Dial. Transplant.
  
  Volume: 29 Pages: 611-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670451
[Journal Article] The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease.2014
- Author(s)
  Hashikata, A., Yamashita, A., Suzuki, S., Nagayasu, S., Shinjo, T., Taniguchi, A., Fukushima, M., Nakai, Y., Nin, K., Watanabe, N., Asano, T., Abiko, Y., Kushiyama, A., Nagasaka, S.,and Nishimura, F.
- Journal Title
  
  Nephrol. Dial. Transplant.
  
  Volume: 29 Pages: 611-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293219
[Journal Article] Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis.2014
- Author(s)
  Ozoe, A., Sone, M., Fukushima, T., Kataoka, N., Chida, K., Asano, T., Hakuno, F., and Takahashi, S.
- Journal Title
  
  Front Endocrinol.
  
  Volume: 5 Pages: 1-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293219
[Journal Article] Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation2014
- Author(s)
  Kawashima Y, Hakuno F, Okada SI, Hotsubo T, Kinoshita T, Fujimoto M, Nishimura R, Fukushima T, Hanaki K, Takahashi SI, Kanzaki S
- Journal Title
  
  Clinical Endocrinology (Oxf)
  
  Volume: Epub ahead of print Issue: 2 Pages: 1-3
- DOI
  10.1111/cen.12317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591512, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25461551
[Journal Article] Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis.2014
- Author(s)
  Ozoe, A., Sone, M., Fukushima, T., Kataoka, N., Chida, K., Asano, T., Hakuno, F., and Takahashi, S.
- Journal Title
  
  Front Endocrinol.
  
  Volume: 5 Pages: 1-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670451
[Journal Article] インスリン様活性と高齢化社会で克服すべき疾病2013
- Author(s)
  高橋伸一郎、伯野史彦、亀井宏泰、Leonard Girnita、Ignacio Torres-Aleman、東祐輔、福嶋俊明、柴野卓志、尾添淳文、山中大介
- Journal Title
  
  化学と生物
  
  Volume: 51(6)
- NAID
  10031177626
- Data Source
  KAKENHI-PROJECT-24790928
[Journal Article] Integrator complex plays anessential role inadipose differentiation2013
- Author(s)
  Otani Y, Nakatsu Y, Sakoda H, Fukushima T, Fujishiro M, Kushiyama A, Okubo H, Tsuchiya Y, Ohno H, Takahashi S, Nishimura F, Kamata H, Katagiri H, Asano T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 434 Issue: 2 Pages: 197-202
- DOI
  10.1016/j.bbrc.2013.03.029
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117012, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24591315, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928
[Journal Article] Insulin Receptor Substrate-1 (IRS-1) Forms a Ribonucleoprotein Complex Associated with Polysomes2013
- Author(s)
  Ozoe A, Sone M, Fukushima T, Kataoka N, Arai T, Chida K, Asano T, Hakuno F, Takahashi S-I
- Journal Title
  
  FEBS Lett.
  
  Volume: 587(15) Issue: 15 Pages: 2319-24
- DOI
  10.1016/j.febslet.2013.05.066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25660210
[Journal Article] Valsartan Restores Inflammatory Response by Macrophages in Adipose and Hepatic Tissues of LPS-infused Mice.2013
- Author(s)
  Iwashita M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima T, Kumamoto S, Kamata H, Nishimura F, Asano T.
- Journal Title
  
  Adipocyte
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790928
[Journal Article] Lactobacillus casei strain Shirota protects against non-alcoholic steatohepatitis development in a rodent model2013
- Author(s)
  Okubo H, Sakoda H, Kushiyama A, Fujishiro M, Nakatsu Y, Fukushima T, Matsunaga Y, Kamata H, Asahara T, Yoshida Y, Chonan O, Iwashita M, Nishimura F, Asano T
- Journal Title
  
  American Journal Physiolgy-Gastrointestinal and Liver Physiogy
  
  Volume: 305 Issue: 12 Pages: 911-918
- DOI
  10.1152/ajpgi.00225.2013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117012, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24591315, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25461372
[Journal Article] Par14 associates with IRS-1, thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.2013
- Author(s)
  Zhang J, Nakatsu Y, Sinjo T, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T.
- Journal Title
  
  Ｊournal of Biological Chemistry
  
  Volume: 288 Issue: 28 Pages: 20692-20701
- DOI
  10.1074/jbc.m113.485730
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117012, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24591315, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25461372
[Journal Article] Resistin-Like Molecule β Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development.2013
- Author(s)
  Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 33 Issue: 8 Pages: 1986-1993
- DOI
  10.1161/atvbaha.113.301546
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20117012, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-23591099, KAKENHI-PROJECT-23659107, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-24249047, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24591315, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PUBLICLY-25111705, KAKENHI-PROJECT-25460416, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-25670762
[Journal Article] Phosphatidylinsitol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.2012
- Author(s)
  Fukushima T, Nakamura Y, Yamanaka D, Shibano T, Chida K, Minami S, Asano T, Hakuno F, Takahashi S-I.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Issue: 35 Pages: 29713-29721
- DOI
  10.1074/jbc.m112.393074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928
[Journal Article] Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation2012
- Author(s)
  Kawashima Y, Higaki K, Fukushima T, Hakuno F, Nagaishi JI, Hanaki K, Nanba E, Takahashi SI, Kanzaki S
- Journal Title
  
  Clin.Endocrinol.
  
  Volume: (in press) Issue: 2 Pages: 246-54
- DOI
  10.1111/j.1365-2265.2012.04357.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345, KAKENHI-PROJECT-21591324, KAKENHI-PROJECT-22591128, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-24591512, KAKENHI-PROJECT-24790928
[Journal Article] Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs2012
- Author(s)
  Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura S, Natsume T, Asano T, Chida K, Girnita L, Takahashi S-I
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 423 Issue: 1 Pages: 122-127
- DOI
  10.1016/j.bbrc.2012.05.093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22687009, KAKENHI-PROJECT-23658222, KAKENHI-PROJECT-24380152, KAKENHI-PROJECT-24790928
[Journal Article] Phosphatidylinositol 3-Kinase Binding Protein, PI3KAP/XB130 is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells2012
- Author(s)
  山中大介, 福嶋俊明, 他
- Journal Title
  
  Endocrinology
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780249
[Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development2012
- Author(s)
  Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 32 Issue: 2 Pages: 291-298
- DOI
  10.1161/atvbaha.111.234559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390238, KAKENHI-PROJECT-21390556, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PUBLICLY-23013007, KAKENHI-PROJECT-23659107, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-24249047, KAKENHI-PROJECT-24790928
[Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.2012
- Author(s)
  Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
- Journal Title
  
  American Journal of Physiology - Endocrinology and Metabolism
  
  Volume: 302 Issue: 3 Pages: 286-296
- DOI
  10.1152/ajpendo.00324.2011
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117012, KAKENHI-PROJECT-21390556, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-23390213, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022, KAKENHI-PROJECT-24790928
[Journal Article] Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model2012
- Author(s)
  Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 53 Pages: 44526-44535
- DOI
  10.1074/jbc.m112.397133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390556, KAKENHI-PUBLICLY-23013007, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-23659107, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022, KAKENHI-PROJECT-24249047, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24591315, KAKENHI-PROJECT-24790928
[Journal Article] Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases2011
- Author(s)
  Fukushima T, Arai T, Ariga M, Okajima H, Ooi Y, Iijima Y, Sone M, Cho Y, Ando Y, Kasahara K, Ozoe A, Yoshihara H, Chida K, Okada S, Kopchick JJ, Hakuno F, Takahashi S-I
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 404 Issue: 3 Pages: 767-773
- DOI
  10.1016/j.bbrc.2010.12.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249
[Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011
- Author(s)
  Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 23 Pages: 20812-20822
- DOI
  10.1074/jbc.m110.206904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390556, KAKENHI-PLANNED-22126006, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PROJECT-22790869, KAKENHI-PROJECT-23390238, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022
[Journal Article] Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin insulin-like growth factor-I receptor tyrosine kinases.2011
- Author(s)
  福嶋俊明, 他
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 404(3) Pages: 767-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780249
[Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity.2011
- Author(s)
  大野晴也、福嶋俊明, 他
- Journal Title
  
  American Journal of Physiology-Cell Physiology
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780249
[Journal Article] HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells2011
- Author(s)
  Fukushima T, Okajima H, Yamanaka D, Ariga M, Nagata S, Ito A, Yoshida H, Asano T, Chida K
- Journal Title
  
  Mol.Cell Endocrinol.
  
  Volume: 344 Issue: 1-2 Pages: 81-90
- DOI
  10.1016/j.mce.2011.06.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580345, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249
[Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011
- Author(s)
  中津祐介、福嶋俊明, 他
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780249
[Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011
- Author(s)
  Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
- Journal Title
  
  Am J Physiol Cell Physiol
  
  Volume: 300(5) Issue: 5 Pages: 1047-54
- DOI
  10.1152/ajpcell.00416.2010
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22126006, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PROJECT-22790869, KAKENHI-PROJECT-23390238, KAKENHI-PROJECT-23791047
[Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity.2010
- Author(s)
  中津祐介、福嶋俊明, 他
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 285(43) Pages: 33018-27
- NAID
  120006471211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780249
[Journal Article] Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.2010
- Author(s)
  柴田倫宏、福嶋俊明, 他
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 285(27) Pages: 20915-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780249
[Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity2010
- Author(s)
  Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Issue: 43 Pages: 33018-33027
- DOI
  10.1074/jbc.m110.137836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390238, KAKENHI-PROJECT-21390556, KAKENHI-PROJECT-22780249
[Journal Article] Paraquat-induced oxidative stressrepresses phosphatidyl inositol 3-kinaseactivities leading to impaired glucoseuptake in 3T3-L1 adipocytes2010
- Author(s)
  柴田倫宏、福嶋俊明(5番目)他12名
- Journal Title
  
  The Journalof biological chemistry
  
  Volume: 285 Issue: 27 Pages: 20915-25
- DOI
  10.1074/jbc.m110.126482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780249
[Patent] クッシング病治療剤のスクリーニング方法2018
- Inventor(s)
  福嶋俊明
- Industrial Property Rights Holder
  国立大学法人東京工業大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] 卵巣プロテオミクスによるプロテインキナーゼ NRKの機能解明2023
- Author(s)
  伝田公紀, 清田雅哉, Wong Sing Ying, 伏見海, 加藤明, Beni Lestari, 福嶋俊明, 駒田雅之, 林宣宏
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06039
[Presentation] NRKによるCK2活性制御の構造モデリングと解析2023
- Author(s)
  吉村玲奈, Beni Lestari, 福嶋俊明, 森次圭
- Organizer
  第61回日本生物物理学会
- Data Source
  KAKENHI-PROJECT-22K06039
[Presentation] Molecular mechanisms underlying tumor suppressor NRK promotes apoptotic cell death2023
- Author(s)
  Beni Lestari, Akira Kato Masayuki Komada, Toshiaki Fukushima
- Organizer
  第83回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K06039
[Presentation] Ubiquitination-mediated activation of AKT and its cancer-associated mutants2022
- Author(s)
  Marsya Yonna Nurrachma, Beni Lestari, 駒田雅之, 福嶋俊明
- Organizer
  第45回日本分子生物学会年会,
- Data Source
  KAKENHI-PUBLICLY-21H00276
[Presentation] 脱ユビキチン化酵素USP8によるVAMP8の制御とその細胞質分裂における意義の解明2022
- Author(s)
  西岡柚香, 柿原慧遵, 遠藤彬則, 駒田雅之, 福嶋俊明
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-21H00276
[Presentation] 脱ユビキチン化酵素USP8の遺伝子変異を介したクッシング病の発症メカニズム2022
- Author(s)
  福嶋俊明, 柿原慧遵, 駒田雅之
- Organizer
  第27回日本病態プロテアーゼ学会学術集会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00276
[Presentation] クッシング病を引き起こすUSP8の過剰活性化機構2022
- Author(s)
  福嶋俊明, 柿原慧遵, 浅水謙吾, 森次圭, 北口哲也, 駒田雅之
- Organizer
  第95回日本生化学会大会シンポジウム「ユビキチンワールドを制御する脱ユビキチン化酵素の疾患、創薬における重要性」
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00276
[Presentation] Caspase-dependent STAMBPL1 cleavage promotes cell death through its C-terminal fragment with hyperactive deubiquitinating activity2022
- Author(s)
  Keijun Kakihara, Masayuki Komada, Toshiaki Fukushima
- Organizer
  The International Symposium in Tokyo 2022 “Ubiquitin New Frontier “from Neo-Biology to Target Protein Degradation”
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00276
[Presentation] Cis-activity regulation of USP8 and STAMBPL1, two endosomal deubiquitinating enzymes, and role of dysregulation in disease onset2022
- Author(s)
  柿原慧遵, 駒田雅之, 福嶋俊明
- Organizer
  TMiMS国際シンポジウム「New Frontiers in Ubiquitin Proteasome System」
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00276
[Presentation] Molecular mechanisms underlying the over-activation of USP8 and USP48 by Cushing’s disease-associated mutations2022
- Author(s)
  Gai Ando, Keijun Kakihara, Masayuki Komada, Toshiaki Fukushima
- Organizer
  The International Symposium in Tokyo 2022 “Ubiquitin New Frontier “from Neo-Biology to Target Protein Degradation”
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00276
[Presentation] Autoinhibition of USP8 by WW-like domain and the dysregulation in Cushing’s disease2022
- Author(s)
  Keijun Kakihara, Kei Moritsugu, Tetsuya Kitaguchi, Akinori Endo, Masayuki Komada, Toshiaki Fukushima
- Organizer
  EMBO Workshop “Ubiquitin and ubiquitin-like proteins in health and disease”
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00276
[Presentation] Ubiquitination-mediated activation of AKT and its cancer-associated mutants2022
- Author(s)
  Marsya Yonna Nurrachma, Beni Lestari, 駒田雅之, 福嶋俊明
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06039
[Presentation] クッシング病の治療薬開発を目指したUSP8-STAM1複合体を作用点とするACTH分泌制御物質の開発2021
- Author(s)
  福嶋俊明
- Organizer
  第6回橋渡し研究戦略的推進プログラムシンポジウム
- Data Source
  KAKENHI-PUBLICLY-19H05289
[Presentation] 脱ユビキチン酵素USP8はレンチウイルス粒子へのウイルスRNAの動員を阻害することによってウイルスの増殖を防ぐ2021
- Author(s)
  Yuya Himi, Keijun Kakihara, Akira Kato, Masayuki Komada, Toshiaki Fukushima
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-21H00276
[Presentation] クッシング病の治療薬開発を目指したUSP8-STAM1複合体を作用点とするACTH分泌制御物質の開発2021
- Author(s)
  福嶋俊明
- Organizer
  第6回橋渡し研究戦略的推進プログラムシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] レンチウイルス粒子へのウイルスRNAの動員はGagのユビキチン化によって促進される2021
- Author(s)
  Yuya Himi, Keijun Kakihara, Akira Kato, Masayuki Komada, Toshiaki Fukushima
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PUBLICLY-21H00276
[Presentation] Cushing’s disease-associated mutation releases autoinhibition of the deubiquitinating enzyme USP82021
- Author(s)
  Keijun Kakihara, Kengo Asamizu, Kei Moritsugu, Tetsuya Kitaguchi, Akinori Endo, Akinori Kidera, Mittsunori Ikeguchi, Masayuki Komada, Toshiaki Fukushima
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-21H00276
[Presentation] Constitutive formation of USP8-STAM1 complex plays an important role in the onset of Cushing’s disease2019
- Author(s)
  Toshiaki Fukushima, Yuka Madoka, Akinori Endo, Kohei Kawaguchi, Saki Arakaki, Masayuki Komada
- Organizer
  The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05289
[Presentation] Ornithine regulates gluconeogenic gene expression independently from well-established hormonal signaling pathways in hepatocytes.2019
- Author(s)
  Sara Fukushima, Mikako Kumano, Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Yuka Toyoshima, Asako Takenaka, Fumihiko Hakuno, Shin-Ichiro Takahashi.
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] Mechanisms underlying hepatic steatosis induced by total dietary amino acid deficiency and arginine only deficiency; Novel amino acid signals inducing insulin-like activities.2019
- Author(s)
  Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Haruka Nagata, Sara Fukushima, Yuka Toyoshima, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference on IGF & insulin physiology & Diseases “The Impact of IGF and Insulin on Life-Long Health”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] A novel autoinhibitory mechanism of ubiquitin-specific protease 8 activity via the intramolecular interaction2019
- Author(s)
  Keijun Kakihara, Kengo Asamizu, Akinori Endo, Masayuki Komada, Toshiaki Fukushima
- Organizer
  The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05289
[Presentation] A novel autoinhibitory mechanism of ubiquitin-specific protease 8 activity via the intramolecular interaction2019
- Author(s)
  Keijun Kakihara, Kengo Asamizu, Akinori Endo, Masayuki Komada, Toshiaki Fukushima
- Organizer
  The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] A novel autoinhibitory mechanism of ubiquitin-specific protease 8 activity via the intramolecular interaction2019
- Author(s)
  柿原慧遵、浅水謙吾、遠藤彬則、駒田雅之、福嶋俊明
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-19H05289
[Presentation] USP8遺伝子変異によるクッシング病発症機構解明の新展開2019
- Author(s)
  福嶋俊明
- Organizer
  第2回ユビキチン研究会
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] 肝細胞においてオルニチンを介した新規アミノ酸シグナル経路がmTOR非依存的にG6Pase遺伝子発現を制御する2019
- Author(s)
  福嶋沙良、熊野未佳子、西宏起、山中大介、合田祐貴、豊島由香、竹中麻子、片岡直行、伯野史彦、高橋伸一郎
- Organizer
  第42回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-18H03972
[Presentation] USP8-STAM1 deubiquitinating enzyme complex is a novel drug target for Cushing's disease2019
- Author(s)
  Toshiaki Fukushima
- Organizer
  Targeted Protein Degradation Forum in Japan
- Invited
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] Constitutive formation of USP8-STAM1 complex plays an important role in the onset of Cushing’s disease2019
- Author(s)
  Toshiaki Fukushima, Yuka Madoka, Akinori Endo, Kohei Kawaguchi, Saki Arakaki, Masayuki Komada
- Organizer
  The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] Nrk prevents hyperplasia by modulating CK2-PTEN-Akt signaling pathway2019
- Author(s)
  Satomi Naito, Akinori Endo, Kimitoshi Denda, Yuka Madoka, Akira Kato, Masayuki Komada, Toshiaki Fukushima
- Organizer
  The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] Nrk prevents hyperplasia by modulating CK2-PTEN-Akt signaling pathway2019
- Author(s)
  Satomi Naito, Akinori Endo, Kimitoshi Denda, Yuka Madoka, Akira Kato, Masayuki Komada, Toshiaki Fukushima
- Organizer
  The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05289
[Presentation] A novel autoinhibitory mechanism of ubiquitin-specific protease 8 activity via the intramolecular interaction2019
- Author(s)
  柿原慧遵、浅水謙吾、遠藤彬則、駒田雅之、福嶋俊明
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] 脱ユビキチン化酵素USP8の自己活性抑制機構2019
- Author(s)
  柿原慧遵、浅水謙吾、遠藤彬則、駒田雅之、福嶋俊明
- Organizer
  第2回ユビキチン研究会
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] USP8-STAM1 deubiquitinating enzyme complex is a novel drug target for Cushing's disease2019
- Author(s)
  Toshiaki Fukushima
- Organizer
  Targeted Protein Degradation Forum in Japan
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05289
[Presentation] Nuclear localization mechanism of deubiquitinating enzyme USP8 in Cushing’s disease.2018
- Author(s)
  Takahiro Sawada, Kazuya Inoko, Kohei Kawaguchi, Akinori Endo, Yasushi Saeki, Keiji Tanaka, Toshiaki Fukushima, Masayuki Komada
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] Molecular mechanisms underlying the control of Nrk protein levels and Nrk-mediated anti-proliferation effects.2018
- Author(s)
  Satomi Naito, Akinori Endo, Toshiaki Fukushima, Kimitoshi Denda, Akira Kato, Masayuki Komada
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] A deubiquitinase USP8, a master regulator of endosome-centered membrane traffic, controls inter-cellular signal transduction.2018
- Author(s)
  Akinori Endo, Toshiaki Fukushima, Masayuki Komada
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] Ubiquitin-specific protease 8 suppresses collagen secretion by deubiquitinating Sec31.2018
- Author(s)
  Kohei Kawaguchi, Akinori Endo, Toshiaki Fukushima, Masayuki Komada
- Organizer
  Cell and Developmental Biology Meeting
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] USP8, a deubiquitinating enzyme in the endocytic pathway, plays roles in proteostasis in the secretory pathway.2018
- Author(s)
  Toshiaki Fukushima
- Organizer
  Tokyo Tech WRHI-Cell Biology Center Mini-Symposium on Proteostasis in the Cell
- Invited
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] USP8 遺伝子のゲノム編集によるCushing 病モデル細胞の作製と解析2018
- Author(s)
  Suguru Machidori, Kazuya Inoko, Kohei Kawaguchi, Akinori Endo, Toshiaki Fukushima, Masayuki Komada
- Organizer
  The 33th Japanese Society of Pituitary Research Meeting
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] Deubiquitinases USP5 and USP13 are recruited to and regulate heat-induced stress granules by deubiquitinating activities.2018
- Author(s)
  Xie Xuan, Shunsuke Matsumoto, Akinori Endo, Toshiaki Fukushima, Hiroyuki Kawahara, Yasushi Saeki, Masayuki Komada
- Organizer
  Cold Spring Harbor Asia Conferences, Ubiquitin Family, Autophagy and Diseases
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] セリン/スレオニン脱リン酸化酵素PPM1Bによる脱ユビキチン化酵素USP8の新しい制御機構2017
- Author(s)
  久保正英、浅水謙吾、遠藤彬則、猪子和也、川口紘平、福嶋俊明、駒田雅之
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] Cushing病における脱ユビキチン化酵素USP8の過剰活性化機構2017
- Author(s)
  浅水謙吾、川口紘平、遠藤彬則、福嶋俊明、金丸周司、駒田雅之
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] 脱ユビキチン化酵素USP8の活性化型変異体が ACTH産生細胞に発現する種々の膜受容体タンパク質に及ぼす影響2017
- Author(s)
  永田双葉、福嶋俊明、遠藤彬則、川口紘平、駒田雅之
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] Cushing病で見られる変異型脱ユビキチン化酵素USP8が核内で果たす役割の解明2017
- Author(s)
  猪子和也、澤田崇広、遠藤彬則、佐伯泰、田中啓二、Ardisasmita Ibrahim、福嶋俊明　駒田雅之
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08625
[Presentation] Nedd4-induced mono-ubiquitination of IRS-2 enhances IGF/insulin signaling through a novel mechanism2017
- Author(s)
  福嶋俊明
- Organizer
  Core-to-Core Program “New Insights into the Molecular Basis of Prevention of Diseases in the Aging Society Caused by Modulation of Insulin-Like Activities” International Seminar
- Place of Presentation
  東京
- Year and Date
  2017-01-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] インスリン受容体基質IRSはG3BP1と相互作用し、 cap非依存的翻訳を促進する2016
- Author(s)
  中沖優里、尾添淳文、曽根芽里、山中大介、福嶋俊明、片岡直行、浅野知一郎、千田和広、伯野史彦、高橋伸一郎
- Organizer
  日本農芸化学会
- Place of Presentation
  札幌
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] クッシング病で見られる脱ユビキチン化酵素USP8の変異はバソプレシン受容体V1bの安定化を引き起こす2016
- Author(s)
  福嶋俊明　川口紘平　遠藤彬則　駒田雅之
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] クッシング病における変異型USP8によるバソプレシン受容体V1bの安定化2016
- Author(s)
  福嶋俊明
- Organizer
  新学術領域【ユビキチンネオバイオロジー】第3回領域会議
- Place of Presentation
  札幌
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] 脳下垂体の腫瘍性疾患クッシング病における脱ユビキチン化酵素USP8の活性化変異2015
- Author(s)
  駒田雅之、川口紘平、Arif Ibrahim Ardisasmita、福嶋俊明
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] クッシング病で見られる脱ユビキチン化酵素USP8の変異体は ACTH分泌を制御するバソプレシン受容体V1bを安定化する2015
- Author(s)
  福嶋俊明
- Organizer
  新学術領域【ユビキチンネオバイオロジー】第２回領域会議
- Place of Presentation
  南房総
- Year and Date
  2015-12-16
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] Nedd4-induced monoubiquitination of IRS-2 enhances IGF signaling and mitogenic activity2015
- Author(s)
  福嶋俊明
- Organizer
  新学術領域【ユビキチンネオバイオロジー】若手ワークショップ
- Place of Presentation
  京都
- Year and Date
  2015-07-01
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] 非アルコール性脂肪性肝炎におけるLUBAC形成障害の解析2015
- Author(s)
  松永泰花、中津祐介、福嶋俊明、大久保博史、岩下未咲、迫田秀之、藤城緑、山本屋武、櫛山暁史、高橋伸一郎、土谷佳弘、鎌田英明、徳永文稔、岩井一宏、浅野知一郎
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] Novel Mechanisms by which Nedd4-IRS-2 complexes enhance IGF-I signals, and their roles in IGF-I action in prostate cancer cell proliferation2014
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Yasushi Saeki, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Organizer
  The 7h International Congress of the GRS and the IGF Society
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] インスリン受容体RNAの選択的スプライシングの新しい制御機構2014
- Author(s)
  Yuka Narita, Atsufumi Ozoe, Toshiaki Fukushima, Naoyuki Kataoka, Akihiro Ito, Minoru Yoshida, Tomoichiro Asano, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Japan Endocrine Society's Annual Meeting
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] Ubiquitin-conjugation to IRS by ubiquitin ligase Nedd4 drives Insulin/IGF signaling.2013
- Author(s)
  Toshiaki Fukushima
- Organizer
  Core-to-Core Project sponsored by JSPS (FY2012-FY2017) INTERNATIONAL OPEN WORKSHOP
- Place of Presentation
  Stockholm (スウェーデン)
- Invited
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] PGAM5, a mitochondrial protein phosphatase, regulates the serine/threonine phosphorylation status and stability of insulin receptor substrates.2013
- Author(s)
  Yosuke Yoneyama, Junichi Inobe, Yukako Kida, Toshiaki Fukushima, Shiori Sekine, Tomoichiro Asano, Kazuhiro Chida, Kohsuke Takeda, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Annual Meeting of the Molecular Biology Society of Japan,
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] The deubiquitinating enzyme, USP9X positively regulates insulin-like growth factor (IGF)-dependent cell growth by inhibition of degradation of IGF-I receptor (IGF-IR) and insulin receptor substrate (IRS)-2 in cancer cells2013
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] Nedd4-IRS2 complex: mechanisms of the complex formation and its roles in prostate cancer cell proliferation2013
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Kazuhiro Chida, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Yusuke Nakatsu, Hideaki Kamata, Shin-Ichiro Takahashi, Tomoichio Asano
- Organizer
  Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] Ubiquitin ligase Nedd4 interacts with insulin receptor substrate (IRS)-2 in response to humoral/nutritional stimuli, thereby enhancing IRS-2-mediated IGF/insulin signals through a novel mechanism.2012
- Author(s)
  Fukushima T, Yoshihara H, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Chida K, Sakoda H, Asano T, Takahashi SI.
- Organizer
  The 6th International Congress of the GRS and the IGF Society
- Place of Presentation
  ドイツ　ミュンヘン
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] Nedd4 potentiates IRS-2-mediated insulin/IGF signals and bioactivities.2012
- Author(s)
  Fukushima T, Yoshihara H, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Nakatsu Y, Sakoda H, Kamata H, Takahashi SI, Asano T
- Organizer
  Annual Meeting of the Japan Diabetes Society
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] Ubiquitination of insulin receptor substrate by Nedd4 potentiates insul in/IGF signals2011
- Author(s)
  福嶋俊明, 他
- Organizer
  日本生化学会中国四国支部会
- Place of Presentation
  広島市
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Roles of peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 in non-alcoholic steatohepatitis2011
- Author(s)
  中津祐介, 福嶋俊明, 他
- Organizer
  日本生化学会
- Place of Presentation
  京都市
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Ubiquitination of insulin receptor substrate by Nedd4 potentiates insulin/ IGF signals.2011
- Author(s)
  福嶋俊明他
- Organizer
  日本生化学会中国四国支部会
- Place of Presentation
  広島
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate (IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals followed by mitogenic bioactivity of insulin-like growth factors(IGFs)2011
- Author(s)
  福嶋俊明, 他
- Organizer
  Gordon Research Conference : Insul in like growth factors in physiology and disease
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2011-03-01
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] PGAM5, a serine/threonine phosphatase associating with IRS, is required for the enhancement of insulin response2011
- Author(s)
  鋳延淳一, 福嶋俊明, 他
- Organizer
  日本内分泌学会
- Place of Presentation
  神戸市
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate(IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals followed bymitogenic bioactivity of insulin-likegrowth factors(IGFs).2011
- Author(s)
  福嶋俊明他
- Organizer
  Gordon Research Conference : Insulin like growth factors inphysiology and disease.
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2011-03-01
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Nedd4 potentiates insulin signals through ubiquitination of IRS-2 in hepatocytes2011
- Author(s)
  福嶋俊明, 他
- Organizer
  日本生化学会
- Place of Presentation
  京都市
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Roles of peptidyl-prolyl cis/ trans isomerase NIMA-interacting 1 in non-alcoholicstea tohepatitis.2011
- Author(s)
  中津祐介福嶋俊明, 他
- Organizer
  日本生化学会
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Nedd4 potentiates insulin signals through ubiquitination of IRS-2 in hepatocytes.2011
- Author(s)
  福嶋俊明他
- Organizer
  日本生化学会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] PGAM5, aserine/ threonine phosphatase associating with IRS, is required for the enhancement of insulin response.2011
- Author(s)
  鋳延淳一福嶋俊明他
- Organizer
  日本内分泌学会
- Place of Presentation
  神戸
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Insulin receptor substrates (IRSs) form a complex with RNAs, affecting RNA metabolism and translation2010
- Author(s)
  尾添敦史、福嶋俊明, 他
- Organizer
  International Congress of the GRS and the IGF Society
- Place of Presentation
  New York, USA
- Year and Date
  2010-10-06
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Insulinreceptor substrates(IRSs) form a complexwith RNAs, affecting RNA metabolism andtranslation,2010
- Author(s)
  尾添敦史、福嶋俊明他
- Organizer
  International Congress ofthe GRS and the IGF Society
- Place of Presentation
  New York, USA
- Year and Date
  2010-10-06
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate(IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals and mitogenicbioactivity of insulin-like growth factor(IGF).2010
- Author(s)
  福嶋俊明他
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate (IRS)-2 to membranefractions, enhancing IRS-2-mediated signals and mitogenic bioactivity of insulin-like growth factor(IGF).2010
- Author(s)
  福嶋俊明, 他
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Insulin receptor substrates (IRSs) interact with snoRNA.2010
- Author(s)
  尾添敦史、福嶋俊明, 他
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] Insulinreceptor substrates(IRSs) interact with snoRNA.2010
- Author(s)
  尾添敦史、福嶋俊明他
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22780249
[Presentation] キサンチンオキシダーゼ阻害剤FebuxostatによるNASH改善作用の検討
- Author(s)
  藤城緑、中津祐介、福嶋俊明、松永泰花、迫田秀之、櫛山暁史、山本屋武、西村英紀、浅野知一郎
- Organizer
  第５７回日本糖尿病学会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26293219
[Presentation] 膵β細胞からのインスリン分泌におけるプロリン異性化酵素Pin1の役割
- Author(s)
  浅野知一郎、松永泰花、福嶋俊明、山崎広貴、山本屋武、櫛山暁史、中津祐介
- Organizer
  第５７回日本糖尿病学会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26293219
[Presentation] Molecular mechanisms by which ubiquitin ligase Nedd4 enhances IRS-2-mediated IGF signaling
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Yasushi Saeki, Yusuke Nakatsu, Hideaki Kamata, Shin-Ichiro Takahashi, Tomoichiro Asano
- Organizer
  Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  神戸
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] The deubiquitinating enzyme, USP9X positively regulates insulin-like growth factor (IGF)-dependent cell growth by inhibition of degradation of IGF-I receptor (IGF-IR) and insulin receptor substrate (IRS)-2 in cancer cells
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Akihiro Ito, Claire Worrall, Leonard Girnita, Keiji Tanaka, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The International Congress of the GRS and the IGF Society
- Place of Presentation
  Suntec Convention & Exhibition Centre, Suntec City, Singapore
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] Roles of prolyl isomerase Pin1 in pancreatic beta cell function
- Author(s)
  Yusuke Nakatsu, Keiichi Mori, Yasuka Matsunaga, Toshiaki Fukushima, Hideaki Kamata, Ken Yamaguchi, Hisamitsu Ishihara, Tomoichiro Asano
- Organizer
  Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  神戸
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] Roles of prolyl isomerase Pin1 in pancreatic beta cell function
- Author(s)
  Yusuke Nakatsu, Keiichi Mori, Yasuka Matsunaga, Toshiaki Fukushima, Hideaki Kamata, Ken Yamaguchi, Hisamitsu Ishihara, Tomoichiro Asano
- Organizer
  Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  神戸ポートアイランド, 神戸
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] Xanthine oxidase inhibitor febuxostat improves nonalcoholic steatohepatitis
- Author(s)
  Yasuka Matsunaga, Yusuke Nakatsu, Yasuyuki Seno, Aya Katasako, Ryuhei Kanaokam Toshiaki Fukushima, Hideaki Kamata, Tomoichiro Asano
- Organizer
  Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  神戸ポートアイランド, 神戸
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] Novel Mechanisms by which Nedd4-IRS-2 Complexes Enhance IGF-I signals, and their Roles in IGF-I Action in Prostate Cancer Cell Proliferation
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Yasushi Saeki, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Organizer
  The International Congress of the GRS and the IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] キサンチンオキシダーゼ阻害剤FebuxostatによるNASH改善作用の検討
- Author(s)
  藤城緑、中津祐介、福嶋俊明、松永泰花、迫田秀之、櫛山暁史、山本屋武、西村英紀、浅野知一郎
- Organizer
  第５７回日本糖尿病学会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26670451
[Presentation] 非アルコール性脂肪性肝炎発症におけるLUBAC形成障害の役割
- Author(s)
  松永泰花、中津祐介、鎌田英明、福嶋俊明、岩下未咲、新城尊徳、菊池貴子、藤城緑、浅野知一郎
- Organizer
  第５７回日本糖尿病学会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26293219
[Presentation] The deubiquitinating enzyme, USP9X positively regulates insulin-like growth factor (IGF)-dependent cell growth by inhibition of degradation of IGF-I receptor (IGF-IR) and insulin receptor substrate (IRS)-2 in cancer cells
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Akihiro Ito, Claire Worrall, Leonard Girnita, Keiji Tanaka, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  The International Congress of the GRS and the IGF Society
- Place of Presentation
  Singapore
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] The deubiquitinating enzyme, USP9X positively regulates IGF-I-dependent cell growth by inhibition of degradation of insulin receptor substrate (IRS)-2 in cancer cells
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF and Insulin System in Physiology and disease
- Place of Presentation
  Ventura Beach Marriott, Ventura, USA
- Year and Date
  2015-03-08 – 2015-03-13
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] The deubiquitinating enzyme, USP9X positively regulates IGF-I-dependent cell growth by inhibition of degradation of insulin receptor substrate (IRS)-2 in cancer cells
- Author(s)
  Haruka Furuta, Hidehito Yoshihara, Toshiaki Fukushima, Yasushi Saeki, Keiji Tanaka, Akihiro Ito, Minoru Yoshida, Tomoichio Asano, Kazuhiro Chida, Fumihiko Hakuno, Shin-Ichiro Takahashi
- Organizer
  Gordon Research Conference: IGF and Insulin System in Physiology and disease
- Place of Presentation
  Ventura, USA
- Year and Date
  2015-03-08 – 2015-03-13
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] 膵β細胞からのインスリン分泌におけるプロリン異性化酵素Pin1の役割
- Author(s)
  浅野知一郎、松永泰花、福嶋俊明、山崎広貴、山本屋武、櫛山暁史、中津祐介
- Organizer
  第５７回日本糖尿病学会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26670451
[Presentation] Xanthine oxidase inhibitor febuxostat improves nonalcoholic steatohepatitis
- Author(s)
  Yasuka Matsunaga, Yusuke Nakatsu, Yasuyuki Seno, Aya Katasako, Ryuhei Kanaokam Toshiaki Fukushima, Hideaki Kamata, Tomoichiro Asano
- Organizer
  Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  神戸
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24790928
[Presentation] Novel Mechanisms by which Nedd4-IRS-2 Complexes Enhance IGF-I signals, and their Roles in IGF-I Action in Prostate Cancer Cell Proliferation
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Yasushi Saeki, Yusuke Nakatsu, Hideaki Kamata, Tomoichiro Asano, and Shin-Ichiro Takahashi
- Organizer
  The International Congress of the GRS and the IGF Society
- Place of Presentation
  Suntec Convention & Exhibition Centre, Suntec City, Singapore
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26460369
[Presentation] プロリン異性化酵素Pin1はAMPKγ subunitに結合し、活性を抑制する
- Author(s)
  中津祐介、岩下未咲、福嶋俊明、菊池貴子、櫛山暁史、迫田秀之、浅野知一郎
- Organizer
  第５７回日本糖尿病学会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26670451
[Presentation] プロリン異性化酵素Pin1はAMPKγ subunitに結合し、活性を抑制する
- Author(s)
  中津祐介、岩下未咲、福嶋俊明、菊池貴子、櫛山暁史、迫田秀之、浅野知一郎
- Organizer
  第５７回日本糖尿病学会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26293219
[Presentation] 非アルコール性脂肪性肝炎発症におけるLUBAC形成障害の役割
- Author(s)
  松永泰花、中津祐介、鎌田英明、福嶋俊明、岩下未咲、新城尊徳、菊池貴子、藤城緑、浅野知一郎
- Organizer
  第５７回日本糖尿病学会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26670451
[Presentation] Molecular mechanisms by which ubiquitin ligase Nedd4 enhances IRS-2-mediated IGF signaling
- Author(s)
  Toshiaki Fukushima, Hidehito Yoshihara, Haruka Furuta, Fumihiko Hakuno, Yasushi Saeki, Yusuke Nakatsu, Hideaki Kamata, Shin-Ichiro Takahashi, Tomoichiro Asano
- Organizer
  Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  神戸ポートアイランド, 神戸
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26460369
[]
[]

1. Asano Tomoichiro (70242063)

# of Collaborated Projects: 2 results

# of Collaborated Products: 36 results
2. NAKATSU YUSUKE (20452584)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
3. SAKODA HIDEYUKI (50376464)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
4. FUJISHIRO MIDORI (50420211)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
5. HONDA HIROAKI (40245064)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. ITO Akihiro (40391859)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. SAEKI Yasushi (80462779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. Takahashi Shin-Ichiro (00197146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
9. 伯野史彦 (30282700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
10. KOGA Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. OKADA Shin-ichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. ONO Hiraku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 西村英紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 鎌田英明

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
15. 田中利明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 栗原由紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 栗原裕基

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 駒田雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 佐藤浩平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 松原昭郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 片桐秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 鞁嶋有紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 神崎晋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 花木啓一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 徳永文稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fukushima Toshiaki 福嶋 俊明

TOSHIAKI Fukushima 福嶋 俊明

Research Projects

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Co-Researchers

胎盤特異的に発現する増殖因子シグナル調節タンパク質による胎盤の発達や機能の制御Principal Investigator

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USP8の自己阻害機構の理解に基づく阻害剤開発とクッシング病治療への応用Principal Investigator

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ケモテクノロジーを活用した脱ユビキチン化酵素USP8の作用機構の解明Principal Investigator

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Regulatory mechanism of ubiquitin modification of insulin receptor substrates and its physiological and pathological significance.

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The regulatory mechanism of IRS monoubiquitination, a vital process regulating insulin/IGF signalingPrincipal Investigator

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Roles of Pin1 and PAR 14 on the metabolic regulations

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Roles of Nedd4-IRS complexes in the development of diabetes and cancerPrincipal Investigator

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Roles of trk-fused gene product protein

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Novel regulatory mechanism of insulin activity through IRS monoubiquitinationPrincipal Investigator

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Physiological roles of ARF1 mRNA interacting with insulin receptor substratesPrincipal Investigator

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mRNAの局所的翻訳制御におけるインスリン受容体基質の新機能解明Principal Investigator

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[Book] Progress in Molecular Biology and Translational Science: When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling2016

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[Journal Article] USP8 prevents aberrant NF-kappaB and Nrf2 activation by counteracting ubiquitin signals from endosomes.2024

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Fukushima Toshiaki 福嶋俊明

TOSHIAKI Fukushima 福嶋俊明

[Journal Article] コラーゲンの細胞内輸送の分子機構　-脱ユビキチン化酵素USP8による輸送制御-2020

[Journal Article] コラーゲンの細胞内輸送の分子機構　-脱ユビキチン化酵素USP8による輸送制御-2020