Takeuchi Toshihide 武内敏秀

… Alternative Names

武内敏秀タケウチトシヒデ

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Researcher Number	70600120
Other IDs
Affiliation (Current)	2025: 近畿大学, ライフサイエンス研究所, 准教授
Affiliation (based on the past Project Information) *help	2025: 近畿大学, ライフサイエンス研究所, 准教授 2019 – 2024: 近畿大学, ライフサイエンス研究所, 講師 2016 – 2019: 大阪大学, 医学系研究科, 寄附講座講師 2017: 京都大学, 化学研究所, 助教 2016: 大阪大学, 医学(系)研究科(研究院), 寄附講座講師 2013 – 2015: 京都大学, 化学研究所, 助教 2011: 独立行政法人国立精神・神経医療研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Neurology / Biomolecular chemistry / Neurochemistry/Neuropharmacology Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Drug development chemistry / Neurology
Keywords	Principal Investigator エクソソーム / 神経変性疾患 / タンパク質凝集 / 環境要因 / 環境因子 / バイオマーカー / プロテオスターシス / ドラッグデザイン / 血液脳関門 / 脳内移行性キャリア … More / 凝集阻害化合物 / 脳内送達 / 分子シャペロン / ポリグルタミン病 / オリゴマー / シンデカン … More Except Principal Investigator 蛋白質 / 脳神経疾患 / 薬剤スクリーニング / 非膜性オルガネラ / 液-液相分離 / 薬物送達 / 細胞 / 薬学 / エンドソーム膜不安定化ペプチド / バイオ高分子医薬品 / バイオ医薬品 / 膜傷害性ペプチド / クモ毒 / マクロピノサイトーシス / エンドサイトーシス / 抗体 / 細胞内送達 / タンパク質 / 痴呆 / 分子シャペロン / エクソソーム / 神経科学 / ストレス / 認知症 Less

ストレス応答の回復過程におけるストレス顆粒クリアランス機構の解明と病的意義Principal Investigator
- Principal Investigator
  
  武内敏秀
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kindai University
Elucidation of pathomechanisms and development of preventive therapies targeting protein LLPS for neurodegenerative diseases
- Principal Investigator
  
  永井義隆
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Kindai University
エクソソームによるタンパク質クリアランス機構の解明と病的意義Principal Investigator
- Principal Investigator
  
  武内敏秀
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kindai University
Development of diagnostic biomarkers for neurodegenerative diseases by comprehensive analysis of disease-associated alterations in organismal proteostasisPrincipal Investigator
- Principal Investigator
  
  Takeuchi Toshihide
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kindai University
  Osaka University
Investigation of the role of exosome-mediated maintenance of proteostasis in neurodegenerative diseases.
- Principal Investigator
  
  Nagai Yoshitaka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
New strategy for intracellular delivery of biomacropharmaceuticals
- Principal Investigator
  
  Futaki Shiroh
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto University
Development of molecular therapy for polyglutamine diseases by reverse structure-based drug designPrincipal Investigator
- Principal Investigator
  
  Takeuchi Toshihide
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
  Kyoto University
細胞膜タンパク質のオリゴマー形成制御法の開発とシンデカンの機能解析Principal Investigator
- Principal Investigator
  
  武内敏秀
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Kyoto University
逆ドラッグデザインアプローチによる合理的なポリグルタミン病分子治療薬の開発Principal Investigator
- Principal Investigator
  
  武内敏秀
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  National Center of Neurology and Psychiatry

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book Patent Other

[Book] タンパク質のアモルファス凝集と溶解性―基礎研究からバイオ産業・創薬研究への応用まで－2019
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Total Pages
  283
- Publisher
  シーエムシー出版
- ISBN
  9784781313979
- Data Source
  KAKENHI-PROJECT-16H05325
[Book] パラダイムシフトをもたらすエクソソーム機能研究最前線2017
- Author(s)
  武内敏秀、永井義隆
- Total Pages
  9
- Publisher
  NTS出版
- Data Source
  KAKENHI-PROJECT-26713030
[Book] パラダイムシフトをもたらすエクソソーム機能研究最前線2017
- Author(s)
  武内敏秀、永井義隆
- Total Pages
  282
- Publisher
  エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-16H05325
[Book] Heat Shock Factor2016
- Author(s)
  Fujikake N., Takeuchi T., Nagai Y.
- Total Pages
  301
- Publisher
  Springer Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-16H05325
[Book] 月刊細胞The CELL2016
- Author(s)
  武内敏秀, 永井義隆
- Total Pages
  4
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-26713030
[Journal Article] Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD2023
- Author(s)
  Taminato Tomoya、Takeuchi Toshihide、Ueyama Morio、Mori Kohji、Ikeda Manabu、Mochizuki Hideki、Nagai Yoshitaka
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 32 Issue: 10 Pages: 1673-1682
- DOI
  10.1093/hmg/ddac298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19492, KAKENHI-PROJECT-20H03602, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-23K24054, KAKENHI-PROJECT-21H02840
[Journal Article] Emerging roles of extracellular vesicles in polyglutamine diseases: mutant protein transmission, therapeutic potential, and diagnostics.2022
- Author(s)
  Takeuchi T., Nagai Y.
- Journal Title
  
  Neurochem. Int.
  
  Volume: 157 Pages: 105357-105357
- DOI
  10.1016/j.neuint.2022.105357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02840, KAKENHI-PROJECT-23K24054
[Journal Article] Comparison of serum and plasma as a source of blood extracellular vesicles: Increased levels of platelet-derived particles in serum extracellular vesicle fractions alter content profiles from plasma extracellular vesicle fractions2022
- Author(s)
  Zhang Xiaoman、Takeuchi Toshihide、Takeda Akiko、Mochizuki Hideki、Nagai Yoshitaka
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 6 Pages: e0270634-e0270634
- DOI
  10.1371/journal.pone.0270634
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24054
[Journal Article] Pathogenic and protective roles of extracellular vesicles in neurodegenerative diseases2021
- Author(s)
  Takeuchi T.
- Journal Title
  
  J Biochem
  
  Volume: 169 Issue: 2 Pages: 181-186
- DOI
  10.1093/jb/mvaa131
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02585
[Journal Article] 神経変性疾患とエクソソーム2020
- Author(s)
  武内敏秀、永井義隆
- Journal Title
  
  医学のあゆみ
  
  Volume: 272 Pages: 319-324
- Data Source
  KAKENHI-PROJECT-16H05325
[Journal Article] E46K mutantα-synuclein is more degradation resistant and exhibits greater toxic effects than wild-typeα-synuclein in Drosophila models of Parkinson's disease.2019
- Author(s)
  R. Sakai, M. Suzuki, M. Ueyama, T. Takeuchi, E. N. Minakawa, H. Hayakawa, K. Baba, H. Mochizuki, Y. Nagai
- Journal Title
  
  PLoS ONE
  
  Volume: 14 Issue: 6 Pages: e0218261-e0218261
- DOI
  10.1371/journal.pone.0218261
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07823, KAKENHI-PROJECT-19K07987, KAKENHI-PROJECT-17K19658, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325
[Journal Article] Cytosolic Antibody Delivery by Lipid-sensitive Endosomolytic Peptide2017
- Author(s)
  Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nakase, Tomoka Takatani-Nakase, Fatemeh Madani, Astrid Graslund, Shiroh Futaki
- Journal Title
  
  Nature Chemistry
  
  Volume: in press Issue: 8 Pages: 751-761
- DOI
  10.1038/nchem.2779
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01145, KAKENHI-PROJECT-26713030, KAKENHI-PROJECT-15H02497, KAKENHI-PROJECT-16H02612, KAKENHI-PROJECT-16J09206, KAKENHI-PROJECT-15K07955, KAKENHI-PROJECT-17H00856
[Journal Article] Protein Misfolding and Aggregation as a Therapeutic Target for Polyglutamine Diseases2017
- Author(s)
  Takeuchi Toshihide、Nagai Yoshitaka
- Journal Title
  
  Brain Sci.
  
  Volume: 7 Issue: 10 Pages: 128-128
- DOI
  10.3390/brainsci7100128
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16H05325, KAKENHI-PROJECT-26713030
[Journal Article] Calmodulin EF-hand peptides as Ca2+ -switchable recognition tags2017
- Author(s)
  Oku A, Imanishi M, Noshiro D, Murayama T, Takeuchi T, Nakase I, Futaki S.
- Journal Title
  
  Biopolymers
  
  Volume: in press Issue: 1
- DOI
  10.1002/bip.22937
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H00763, KAKENHI-PROJECT-16H02612, KAKENHI-PROJECT-26713030
[Journal Article] エクソソームによる生体内のタンパク質恒常性の維持2016
- Author(s)
  武内敏秀、永井義隆
- Journal Title
  
  細胞
  
  Volume: 48 Pages: 5-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05325
[Journal Article] エクソソームを介したプロテオスターシス維持機構と神経変性疾患2016
- Author(s)
  武内敏秀、永井義隆
- Journal Title
  
  Dementia Japan
  
  Volume: 30 Pages: 368-376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05325
[Journal Article] Syndecan-4 Is a Receptor for Clathrin-Mediated Endocytosis of Arginine-Rich Cell-Penetrating Peptides2016
- Author(s)
  Yoshimasa Kawaguchi, Toshihide Takeuchi, Keiko Kuwata, Junya Chiba, Yasumaru Hatanaka, Ikuhiko Nakase, Shiroh Futaki
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 印刷中 Issue: 4 Pages: 1119-1130
- DOI
  10.1021/acs.bioconjchem.6b00082
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J05215, KAKENHI-PROJECT-16H02612, KAKENHI-PROJECT-26713030
[Journal Article] Current Understanding of Direct Translocation of Arginine-Rich Cell-Penetrating Peptides and Its Internalization Mechanisms2016
- Author(s)
  Takeuchi T, Futaki S.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 64 Issue: 10 Pages: 1431-1437
- DOI
  10.1248/cpb.c16-00505
- NAID
  130005598028
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26713030
[Journal Article] Relating Structure and Internalization for ROMP-Based Protein Mimics.2016
- Author(s)
  Backlund CM, Takeuchi T, Futaki S, Tew GN.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1858 Issue: 7 Pages: 1443-1450
- DOI
  10.1016/j.bbamem.2016.03.024
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713030
[Journal Article] Cell Penetrating Peptides for Chemical Biological Studies.2015
- Author(s)
  Nakase I., Takeuchi T., and Futaki S.
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1324 Pages: 387-396
- DOI
  10.1007/978-1-4939-2806-4_26
- ISBN
  9781493928057, 9781493928064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26713030
[Journal Article] Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.2015
- Author(s)
  Suzuki M, Fujikake N, Takeuchi T, Kohyama-Koganeya A, Nakajima K, Hirabayashi Y, Wada K, Nagai Y.
- Journal Title
  
  Hum Mol Genet. 2015 Dec 1;24(23):6675-86
  
  Volume: 24 Issue: 23 Pages: 6675-6686
- DOI
  10.1093/hmg/ddv372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19016, KAKENHI-PROJECT-15K19502, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-26713030
[Journal Article] Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level.2015
- Author(s)
  Takeuchi T, Suzuki M, Fujikake N, Popiel HA, Kikuchi H, Futaki S, Wada K, Nagai Y
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: in press Issue: 19
- DOI
  10.1073/pnas.1412651112
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-15K19502, KAKENHI-PROJECT-24591287, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-26713030
[Journal Article] Peptide-based therapeutic approaches for treatment of the polyglutamine diseases2014
- Author(s)
  Takeuchi T., Popiel H.A., Futaki S., Wada K., Nagai Y
- Journal Title
  
  Curr. Med. Chem
  
  Volume: (in press) Issue: 23 Pages: 2575-2582
- DOI
  10.2174/0929867321666140217124038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390237, KAKENHI-PROJECT-24659438, KAKENHI-PUBLICLY-25110741, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-26713030
[Patent] TDP-43の発現量を調節するアンチセンスオリゴヌクレオチド及びその用途2017
- Inventor(s)
  永井義隆、前田和宏、武内敏秀、祖父江元、石垣診祐、佐橋健太郎、他
- Industrial Property Rights Holder
  永井義隆、前田和宏、武内敏秀、祖父江元、石垣診祐、佐橋健太郎、他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-134890
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-26713030
[Patent] 血液脳関門透過性ペプチド2016
- Inventor(s)
  武内敏秀、永井義隆、中川慎介、丹羽正美、道具伸也、他2名
- Industrial Property Rights Holder
  武内敏秀、永井義隆、中川慎介、丹羽正美、道具伸也、他2名
- Industrial Property Rights Type
  特許
- Filing Date
  2016-03-16
- Overseas
- Data Source
  KAKENHI-PROJECT-26713030
[Patent] 血液脳関門透過性ペプチド2015
- Inventor(s)
  武内敏秀、永井義隆、中川慎介、丹羽正美、道具伸也、他２名
- Industrial Property Rights Holder
  武内敏秀、永井義隆、中川慎介、丹羽正美、道具伸也、他２名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-052967
- Filing Date
  2015-03-17
- Data Source
  KAKENHI-PROJECT-26713030
[Patent] 細胞質送達ペプチド2015
- Inventor(s)
  二木史朗、秋柴美沙穂、川口祥正、武内敏秀
- Industrial Property Rights Holder
  二木史朗、秋柴美沙穂、川口祥正、武内敏秀
- Industrial Property Rights Type
  特許
- Filing Date
  2015-09-28
- Overseas
- Data Source
  KAKENHI-PROJECT-26713030
[Patent] 細胞質送達ペプチド2015
- Inventor(s)
  二木史朗、秋柴美沙穂、川口祥正、武内敏秀
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015-09-28
- Overseas
- Data Source
  KAKENHI-PROJECT-15H02497
[Patent] 細胞質送達ペプチド2014
- Inventor(s)
  二木史朗、秋柴美沙穂、川口祥正、武内敏秀
- Industrial Property Rights Holder
  二木史朗、秋柴美沙穂、川口祥正、武内敏秀
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-198741
- Filing Date
  2014-09-29
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] 細胞外小胞を介した凝集性タンパク質のクリアランス2021
- Author(s)
  武内敏秀
- Organizer
  第44回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02585
[Presentation] Extracellular vesicles as blood-based biomarkers for polyglutamine diseases2021
- Author(s)
  武内敏秀、皆川栄子、植田幸嗣、齊藤勇二、高橋祐二、関和彦、永井義隆
- Organizer
  第62回日本神経学会
- Data Source
  KAKENHI-PROJECT-18H02585
[Presentation] Secretion of extracellular vesicles as a cellular response to stress2021
- Author(s)
  Takeuchi T
- Organizer
  Pacifichem 2021
- Invited
- Data Source
  KAKENHI-PROJECT-18H02585
[Presentation] タンパク質の品質管理とエクソソーム2021
- Author(s)
  武内敏秀
- Organizer
  第15回日本臨床ストレス応答学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02585
[Presentation] 神経変性疾患ポリグルタミン病に対するタンパク質凝集阻害薬QAI1の同定とその治療効果2020
- Author(s)
  永井義隆、皆川栄子、ポピエルヘレナ明子、山根宏志、他田正義、高橋俊昭、武内敏秀、望月秀樹、戸田達史、和田圭司、小野寺理
- Organizer
  第93回日本薬理学会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] 国立精神・神経医療研究センターにおけるトランスジェニックマーモセット研究の現状2020
- Author(s)
  中谷輝実、小杉亮人、小泉昌司、小島潮子、川野邊哲代、野上尚武、尾張健介、沼澤秀美、皆川栄子、武内敏秀、富岡郁夫、齊藤祐子、花川隆、永井義隆、和田圭司、関和彦
- Organizer
  第9回日本マーモセット研究会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] 運動は血漿由来エクソソーム分泌を亢進させる2019
- Author(s)
  武田明子、武内敏秀、皆川栄子、永井義隆
- Organizer
  第42回分子生物学会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] Monitoring repeat-associated non-AUG (RAN) translation toward drug screening for ALS/FTD.2019
- Author(s)
  橋本茜、武内敏秀、上山盛夫、森康治、池田学、永井義隆
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] In vitroにおけるalpha-synuclein細胞外分泌機構の検討2019
- Author(s)
  早川英規、馬場孝輔、Choong Chi-Jing、池中建介、武内敏秀、永井義隆、望月秀樹
- Organizer
  第42回日本神経科学会・第62回日本神経化学会合同大会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] Evidence for prion-like conformational transmission of a polyglutamine protein monomer.2019
- Author(s)
  Nagai Y., Ozawa D., Takeuchi T.
- Organizer
  10th Gordon Research Conference on CAG Triplet Repeat Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] E46K α-synuclein mutation confers degradation resistance in Parkinson’s disease model flies.2019
- Author(s)
  堺竜介、鈴木マリ、上山盛夫、武内敏秀、望月秀樹、永井義隆
- Organizer
  第13回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] Prion-like conformational transmission of polyglutamine protein.2019
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] Prion-like conformational transmission between polyglutamine protein monomers.2019
- Author(s)
  Ozawa D., Takeuchi T., Nagai Y.
- Organizer
  Asia Pacific Prion Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] Comparison of serum and plasma as a source of blood extracellular vesicles reveals possible contamination of serum with platelet-derived particles produced during coagulation.2019
- Author(s)
  Zhang X., Takeuchi T., Nagai Y.
- Organizer
  Annual Meeting of International Society for Extracellular Vesicles (ISEV2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] Dysfunction in an autophagy-lysosome degradation pathway promotes secretion of ubiquitinated proteins via extracellular vesicles.2019
- Author(s)
  Takeuchi T, Sakai S, Ando H, Nagai Y.
- Organizer
  International Society of Extracellular Vesicles Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02585
[Presentation] E46K α-synuclein mutation gains resistance to degradation, leading to enhanced toxicity in PD flies.2019
- Author(s)
  堺竜介、鈴木マリ、上山盛夫、武内敏秀、望月秀樹、永井義隆
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] Hsp70を介したエクソソーム分泌制御2019
- Author(s)
  武内敏秀
- Organizer
  第42回日本分子生物学会年会ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-18H02585
[Presentation] Conformational transmission between polyglutamine protein monomers.2019
- Author(s)
  Ozawa D., Takeuchi T., Nagai Y.
- Organizer
  The JSPS Core-toCore Program Seminar; Towards a cure for amyloid diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] ポリグルタミン蛋白質によるプリオン様異常構造伝播2019
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Organizer
  第7回日本アミロイドーシス研究会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] ポリグルタミン蛋白質によるプリオン様異常構造伝播2019
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Organizer
  第14回日本臨床ストレス応答学会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] ペプチドを用いた細胞内送達と脳移行性キャリアの開発2019
- Author(s)
  武内敏秀
- Organizer
  日本薬物動態学会第34回年会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02585
[Presentation] Inhibition of autophagy promotes secretion of autophagy-related proteins via extracellular vesicles.2018
- Author(s)
  Takeuchi T., Sakai S., Nagai Y.
- Organizer
  Keystone Symposia on Selective Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] 不要タンパク質の蓄積ストレス下における細胞外小胞分泌2018
- Author(s)
  武内敏秀、坂井聖子、永井義隆
- Organizer
  第13回臨床ストレス応答学会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] オートファジー機能障害による細胞外小胞分泌2018
- Author(s)
  武内敏秀、永井義隆
- Organizer
  第91回日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] The roles of extracellular vesicles in regulation of protein homeostasis2018
- Author(s)
  Toshihide Takeuchi
- Organizer
  HFSP meeting 2018 in Osaka
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02585
[Presentation] 不要タンパク質の蓄積ストレス下における細胞外小胞分泌2018
- Author(s)
  武内敏秀、坂井聖子、永井義隆
- Organizer
  第13回臨床ストレス応答学会
- Data Source
  KAKENHI-PROJECT-18H02585
[Presentation] Inhibition of autophagy promotes secretion of autophagy-related proteins via extracellular vesicles2018
- Author(s)
  武内敏秀
- Organizer
  Keystone Symposia on Selective Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02585
[Presentation] オートファジー機能障害による細胞外小胞分泌2018
- Author(s)
  武内敏秀、永井義隆
- Organizer
  第91回日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02585
[Presentation] ポリグルタミン蛋白質による異常構造伝播機構の解明2018
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Organizer
  第18回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] 細胞非自律的な細胞機能制御機構の解明2017
- Author(s)
  ○武内敏秀
- Organizer
  日本薬学会　第137年会　受賞講演
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Invited
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] 細胞外小胞の分泌・伝播を介した生体内プロテオスタシス制御2017
- Author(s)
  武内敏秀、永井義隆
- Organizer
  第40回日本分子生物学会・第90回日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] 細胞外小胞の分泌・伝播を介した生体内プロテオスタシス制御2017
- Author(s)
  武内敏秀、永井義隆
- Organizer
  ConBio2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] In vitro assessment of extracellular α-synuclein secretion.2017
- Author(s)
  Hayakawa H., Baba K., Takeuchi T., Choong C.J., Nagano S., Nagai Y., Hagihara K., Mochizuki H.
- Organizer
  The 23rd World Congress of Neurology (WCN 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] ペプチドタグを用いた膜タンパク質のヘテロ二量体形成制御2017
- Author(s)
  飯野真丈、○武内敏秀、渡辺健介、坂井聖子、河野健一、中瀬生彦、二木史朗
- Organizer
  日本薬学会　第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] Induction of exosome secretion and its proteomic changes in the polyglutamine disease models2017
- Author(s)
  Toshihide Takeuchi, Masahiro Kanai, Kohji Ueda, Kazuaki Takafuji, Satoko Sakai, Yoshitaka Nagai
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] Induction of exosome secretion and its proteomic changes in the polyglutamine disease models.2017
- Author(s)
  Takeuchi T., Kanai M., Ueda K., Takafuji K., Sakai S., Nagai Y.
- Organizer
  The 23rd World Congress of Neurology (WCN 2017) (
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] GBA機能喪失はα-シヌクレインの異常構造変化を促進して神経変性を悪化させる2017
- Author(s)
  鈴木マリ、藤掛伸宏、武内敏秀、香山(古金谷)綾子、中嶋和紀、平林義雄、和田圭司、三五一憲、永井義隆
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] グルコセレブロシダーゼ機能欠失はαシヌクレインの異常構造変化を促進して神経変性を増悪する2016
- Author(s)
  鈴木マリ、藤掛伸宏、武内敏秀、香山(古金谷)綾子、中嶋和紀、平林義雄、和田圭司、永井義隆
- Organizer
  第10回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] Hsp70の機能欠損体が示す細胞非自律的な変性抑制2016
- Author(s)
  武内敏秀、鈴木マリ、坂井聖子、二木史朗、和田圭司、永井義隆
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] パーキンソン病リスク遺伝子GBAの機能喪失はα-シヌクレインの異常構造変化を促進して神経変性を悪化させる2016
- Author(s)
  鈴木マリ、藤掛伸宏、武内敏秀、香山(古金谷)綾子、中嶋和紀、平林義雄、和田圭司、永井義隆
- Organizer
  第26回病態生理学会大会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] エクソソームを介した細胞非自律的タンパク質恒常性維持機構2016
- Author(s)
  ○武内敏秀、永井義隆
- Organizer
  第14回神経科学研究会
- Place of Presentation
  東京
- Year and Date
  2016-10-01
- Invited
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] シャペロンのエクソソーム分泌による細胞非自律的プロテオスタシス調節機構2016
- Author(s)
  武内敏秀、永井義隆
- Organizer
  第89回日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] 神経変性疾患における血中エクソソームを利用したバイオマーカーの探索2016
- Author(s)
  金井雅裕、武内敏秀、鈴木マリ、藤田寛美、植田幸嗣、永井義隆
- Organizer
  第8回日本RNAi研究会/第3回日本細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] Syndecan-4 as a Possible Octaarginine Receptor for its Clathrin-Mediated Endocytic Uptake.2016
- Author(s)
  Takeuchi T., Kawaguchi, Y., Kuwata, K., Futaki, S.
- Organizer
  統合物質創製化学推進事業　第５回国際シンポジウム
- Place of Presentation
  名古屋（名古屋大学）
- Year and Date
  2016-01-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] Non-cell autonomous therapeutic effects on polyQ disease models by exosomal chaperone transmission2016
- Author(s)
  ○Takeuchi T, Suzuki M, Fujikake N, Popiel HA, Kikuchi H, Futaki S, Wada K, Nagai Y.
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] Hsp70の機能欠損体が示す細胞非自律的な変性抑制効果2016
- Author(s)
  ○武内敏秀、鈴木マリ、坂井聖子、二木史朗、和田圭司、永井義隆
- Organizer
  第8回日本RNAi研究会
- Place of Presentation
  広島
- Year and Date
  2016-08-30
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] Hsp70の機能欠損体が示す細胞非自律的な変性抑制効果2016
- Author(s)
  武内敏秀、鈴木マリ、坂井聖子、二木史朗、和田圭司、永井義隆
- Organizer
  第8回日本RNAi研究会/第3回日本細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] Non-cell autonomous therapeutic effects on polyQ disease models by exosomal chaperone transmission.2016
- Author(s)
  武内敏秀、鈴木マリ、藤掛伸宏、ポピエル明子、菊地寿枝、二木史朗、和田圭司、永井義隆
- Organizer
  第57回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] Intercellular transmission of molecular chaperones via exosomes contributes to maintenance of organismal protein homeostasis2016
- Author(s)
  ○Takeuchi T, Suzuki M, Fujikake N, Popiel HA, Kikuchi H, Sakai S, Futaki S, Wada K, Nagai Y.
- Organizer
  Cold Spring Harbor Asia Meeting
- Place of Presentation
  上海（中国）
- Year and Date
  2016-12-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] エクソソームを介した細胞非自律的タンパク質恒常性維持機構2016
- Author(s)
  武内敏秀、永井義隆
- Organizer
  第14回神経科学研究会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] Intercellular transmission of molecular chaperones via exosomes contributes to maintenance of organismal protein homeostasis.2016
- Author(s)
  Takeuchi T., Suzuki M., Fujikake N., Popiel H.A., Kikuchi H., Sakai S., Futaki S., Wada K., Nagai Y.
- Organizer
  2016 CSH Asia meeting: Biology & Function of Extracellular Vesicles: Exosomes, Microvesicles & Beyond
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] シャペロンのエクソソーム分泌による細胞非自律的プロテオスタシス調節機構2016
- Author(s)
  ○武内敏秀、永井義隆
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] GBA deficiency accelerates α-synuclein prion-like conversion and promotes its neurotoxicity.2016
- Author(s)
  鈴木マリ、藤掛伸宏、武内敏秀、香山(古金谷)綾子、中嶋和紀、平林義雄、和田圭司、永井義隆
- Organizer
  第57回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05325
[Presentation] 抗体の細胞内送達を実現する天然毒素ペプチドの配列改変2015
- Author(s)
  武内敏秀、秋柴美沙穂、川口祥正、二木史朗
- Organizer
  日本ケミカルバイオロジー学会　第１０回年会
- Place of Presentation
  仙台（東北大学）
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] Intercellular chaperone transmission via exosomes contributes to non-cell autonomous therapeutic effects on polyglutamine disease models2015
- Author(s)
  武内敏秀、鈴木マリ、藤掛伸宏、ポピエル明子、菊地寿枝、二木史朗、和田圭司、永井義隆
- Organizer
  第３８回日本神経科学大会
- Place of Presentation
  神戸（神戸コンベンションセンター）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] 分子シャペロンはエクソソーム細胞間伝播により細胞非自律的な治療効果を発揮する2015
- Author(s)
  武内敏秀、永井義隆
- Organizer
  第３４回日本認知症学会学術集会
- Place of Presentation
  青森（リンクステーションホール青森ほか）
- Year and Date
  2015-10-02
- Invited
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] 分子シャペロンはエクソソームを介した細胞間伝播により個体レベルのプロテオスターシス維持に寄与している2015
- Author(s)
  武内敏秀、鈴木マリ、藤掛伸宏、ポピエル明子、菊地寿枝、二木史朗、和田圭司、永井義隆
- Organizer
  第７回日本RNAi研究会・第２回日本細胞外小胞学会
- Place of Presentation
  広島（グランドプリンスホテル広島）
- Year and Date
  2015-08-26
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] 分子シャペロンのエクソソームを介した細胞間伝播による細胞非自律的なタンパク質の恒常性維持機構2015
- Author(s)
  武内敏秀、鈴木マリ、藤掛伸宏、ポピエル明子、菊地寿枝、二木史朗、和田圭司、永井義隆
- Organizer
  第１０回臨床ストレス応答学会大会
- Place of Presentation
  東京（東京農工大学）
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] Counterion-mediated translocation of polyions: from CPP to DNA
- Author(s)
  Toshihide Takeuchi
- Organizer
  4th Asia-Pacific International Peptide Symposium
- Place of Presentation
  大阪（ホテル阪急エキスポ）
- Data Source
  KAKENHI-PROJECT-25882021
[Presentation] Exosomal transmission of Hsp40 contributes to maintenance of organismal protein homeostasis
- Author(s)
  Toshihide Takeuchi
- Organizer
  国際ミニシンポジウム -Protein Folding and Disease-
- Place of Presentation
  秋田（秋田ビューホテル）
- Data Source
  KAKENHI-PROJECT-25882021
[Presentation] リポソーム型高感度センサー系の開発と応用
- Author(s)
  武内敏秀
- Organizer
  第７回バイオ関連化学シンポジウム
- Place of Presentation
  名古屋（名古屋クラウンホテル）
- Data Source
  KAKENHI-PROJECT-25882021
[Presentation] Hsp40の細胞間伝播を介したタンパク質恒常性維持機構
- Author(s)
  武内敏秀
- Organizer
  第１３４回日本薬学会年会
- Place of Presentation
  熊本（ホテル日航熊本ほか）
- Data Source
  KAKENHI-PROJECT-25882021
[Presentation] シャペロン伝播による細胞非自律的なタンパク質恒常性維持機構
- Author(s)
  武内敏秀、鈴木マリ、藤掛伸宏、ポピエル明子、菊地寿枝、和田圭司、永井義隆
- Organizer
  日本薬学会　第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] Hsp40の細胞間伝播によるタンパク質恒常性（プロテオスターシス）の維持機構
- Author(s)
  武内敏秀
- Organizer
  第８回臨床ストレス応答学会
- Place of Presentation
  松本（信州大）
- Data Source
  KAKENHI-PROJECT-25882021
[Presentation] Maintenance of organismal proteostasis by intercellular transmission of Hsp40 through exosomes.
- Author(s)
  Takeuchi T., Fijikake N., Suzuki M., Popiel H. A., Kikuchi H., Wada K., and Nagai Y.
- Organizer
  第11回日本ショウジョウバエ研究会
- Place of Presentation
  金沢
- Year and Date
  2014-06-04 – 2014-06-06
- Data Source
  KAKENHI-PROJECT-26713030
[Presentation] Hsp40はエクソソーム依存的な細胞間伝播により個体レベルのタンパク質恒常性維持に寄与している
- Author(s)
  武内敏秀
- Organizer
  第３６回日本分子生物学会
- Place of Presentation
  神戸（神戸国際会議場ほか）
- Data Source
  KAKENHI-PROJECT-25882021
[]

1. Nagai Yoshitaka (60335354)

# of Collaborated Projects: 2 results

# of Collaborated Products: 41 results
2. 皆川栄子 (20726252)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. Futaki Shiroh (50199402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KAWANO Kenichi (70732874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAKAJIMA Kazuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 二木史郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 上山盛夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 森康治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 平林義雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeuchi Toshihide 武内 敏秀

武内 敏秀 タケウチ トシヒデ

Research Projects

Research Products

Co-Researchers

ストレス応答の回復過程におけるストレス顆粒クリアランス機構の解明と病的意義Principal Investigator

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Elucidation of pathomechanisms and development of preventive therapies targeting protein LLPS for neurodegenerative diseases

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エクソソームによるタンパク質クリアランス機構の解明と病的意義Principal Investigator

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Review Section

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Development of diagnostic biomarkers for neurodegenerative diseases by comprehensive analysis of disease-associated alterations in organismal proteostasisPrincipal Investigator

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Review Section

Research Institution

Investigation of the role of exosome-mediated maintenance of proteostasis in neurodegenerative diseases.

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New strategy for intracellular delivery of biomacropharmaceuticals

Principal Investigator

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Development of molecular therapy for polyglutamine diseases by reverse structure-based drug designPrincipal Investigator

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細胞膜タンパク質のオリゴマー形成制御法の開発とシンデカンの機能解析Principal Investigator

Principal Investigator

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Research Institution

逆ドラッグデザインアプローチによる合理的なポリグルタミン病分子治療薬の開発Principal Investigator

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[Book] タンパク質のアモルファス凝集と溶解性―基礎研究からバイオ産業・創薬研究への応用まで－2019

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[Book] パラダイムシフトをもたらすエクソソーム機能研究最前線2017

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[Book] パラダイムシフトをもたらすエクソソーム機能研究最前線2017

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[Book] Heat Shock Factor2016

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Takeuchi Toshihide 武内敏秀

武内敏秀タケウチトシヒデ