Matsushita Yosuke 松下洋輔

… Alternative Names

MATSUSHITA Yosuke 松下洋輔

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Researcher Number	70634450
Other IDs
Affiliation (Current)	2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所創薬デザイン研究センター, 研究員 2025: 徳島大学, 先端酵素学研究所, 助教
Affiliation (based on the past Project Information) *help	2023 – 2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所創薬デザイン研究センター, 研究員 2023: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所, 研究員 2021 – 2022: 徳島大学, 先端酵素学研究所, 助教 2018 – 2020: 徳島大学, 先端酵素学研究所(プロテオ), 助教 2016: 徳島大学, 先端酵素学研究所(プロテオ), 助教 2015: 徳島大学, 疾患プロテオゲノム研究センター, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Biological pharmacy Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Tumor biology and related fields / Pathological medical chemistry
Keywords	Principal Investigator 乳がん / 次世代シーケンサー / VUS / 家族性乳がん / 乳癌 / TNBC / トリプルネガティブ乳癌 / PD-1/PD-L1 / 腫瘍免疫 / 免疫チェックポイント阻害剤 / 化合物スクリーニング … More Except Principal Investigator … More 乳癌 / tumor suppressor / breast cancer / 薬剤耐性 / ドラッグデリバリーシステム / 脂質メディエーター / スフィンゴシン-1-リン酸 / 癌移植マウスモデル / 患者由来癌異種移植片 / 薬剤感受性 / 患者由来癌オルガノイド / 薬物療法 / 治療効果予測 / 治療開発 / サイトカイン / 癌微小環境 / バイオマーカー / エリブリン / 創薬 / HER2 / がん特異的発現亢進因子 / がん抑制因子 / ミトコンドリア / 乳がん / タンパク相互作用阻害 / multistep carcinogenesis / drug discovery / プロテオーム / タンパク質 / 生体機能利用 / ゲノム / 癌 / mitochondrial regulation / oncogenic signaling / dephosphorylation / phosphorylation / estrogen signaling Less

脂質メディエーター分子機構の癌特異的阻害による乳癌新治療の実現へ向けた前臨床研究
- Principal Investigator
  
  永橋昌幸
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hyogo Medical University
TNBCにおける膜内在型セリンプロテアーゼRHBDL2の役割解明Principal Investigator
- Principal Investigator
  
  松下洋輔
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
乳癌患者由来オルガノイド・動物モデルの臨床的有用性の検証と新規治療開発への応用
- Principal Investigator
  
  樋口智子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hyogo Medical University
Development of biomarkers and new treatments for metastatic breast cancer by eribulin
- Principal Investigator
  
  三好康雄
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Hyogo Medical University
Identification of novel susceptibility genes and establishment of VUS risk assessment approach in Japanese familial breast cancerPrincipal Investigator
- Principal Investigator
  
  Matsushita Yosuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
  The University of Tokushima
Identification of recurrent genetic and epigenetic alterations of SALL3 in TNBC by comprehensive genomic analysisPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Yosuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokushima
Drug discovery in breast cancer utilizing reactivation of tumor suppressors
- Principal Investigator
  
  KATAGIRI Toyomasa
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  The University of Tokushima
Clarification of novel pathophysiological roles of BIG3 in breast cancer cells
- Principal Investigator
  
  KATAGIRI Toyomasa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
Screening of small molecule compounds that inhibits interaction between PD-1 and PD-L1Principal Investigator
- Principal Investigator
  
  MATSUSHITA Yosuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokushima

All 2022 2021 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] A DDX31/mutant-p53/EGFR axis promotes multistep progression of muscle invasive bladder cancer2018
- Author(s)
  Daizumoto Kei、Yoshimaru Tetsuro、Matsushita Yosuke、Fukawa Tomoya、Uehara Hisaori、Ono Masaya、Komatsu Masato、Kanayama Hiro-omi、Katagiri Toyomasa
- Journal Title
  
  Cancer Research
  
  Volume: － Issue: 9 Pages: 2528-2528
- DOI
  10.1158/0008-5472.can-17-2528
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01575, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-16H05153, KAKENHI-PROJECT-17K10551, KAKENHI-PROJECT-18K09136, KAKENHI-PROJECT-17K19601
[Journal Article] Frequent downregulation of LRRC26 by epigenetic alterations is involved in the malignant progression of triple-negative breast cancer2018
- Author(s)
  Miyagawa Yoshimasa、Matsushita Yosuke、Suzuki Hiromu、Komatsu Masato、Yoshimaru Tetsuro、Kimura Ryuichiro、Yanai Ayako、Honda Junko、Tangoku Akira、Sasa Mitsunori、Miyoshi Yasuo、Katagiri Toyomasa
- Journal Title
  
  International Journal of Oncology
  
  Volume: － Pages: 4301-4301
- DOI
  10.3892/ijo.2018.4301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01575, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-16H05153, KAKENHI-PROJECT-16K19052, KAKENHI-PROJECT-17K10551, KAKENHI-PROJECT-17K19601
[Journal Article] 包括的ゲノム解析を通じた乳癌の発症・進展機構解明の現状と展望2017
- Author(s)
  松下洋輔　吉丸哲郎　片桐豊雅
- Journal Title
  
  乳癌学-最新の診断と治療-
  
  Volume: 75巻増刊号3 Pages: 155-160
- Data Source
  KAKENHI-PROJECT-15K21235
[Journal Article] Stapled BIG3 helical peptide ERAP potentiates antitumour activity for breast cancer therapeutics.2017
- Author(s)
  Yoshimaru T, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中 Issue: 1 Pages: 1821-1821
- DOI
  10.1038/s41598-017-01951-6
- NAID
  120006535017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-17K19492, KAKENHI-PUBLICLY-16H01575, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16H05153
[Journal Article] Stapled BIG3 helical peptide ERAP extends potent antitumor activity for breast cancer therapeutics2017
- Author(s)
  Yoshimaru T, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K21235
[Journal Article] Stapled BIG3 helical peptide ERAP extends potent antitumor activity for breast cancer therapeutics2017
- Author(s)
  Yoshimaru T*, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T*
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] Whole-exome sequencing for the identification of Japanese familial breast cancer susceptibility genes2022
- Author(s)
  Abdullah S. Ili, Yosuke Matsushita, Yasuko Takahashi, Masato Komatsu, Kazuma Kiyotani, Yasuo Miyoshi, Junko Honda, Shozo Ohsumi, Mitsunori Sasa and Toyomasa Katagiri
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07125
[Presentation] Identification and characterization of novel susceptibility genes in hereditary Japanese familial breast cancer2021
- Author(s)
  Ili Syazwana Abdullah, Yosuke Matsushita, Yasuko Takahashi, Masato Komatsu, Kazuma Kiyotani, Yasuo Miyoshi, Junko Honda, Shozo Ohsumi, Mitsunori Sasa, Toyomasa Katagiri
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07125
[Presentation] 日本人家族性乳癌家系の新規感受性遺伝子の解析2021
- Author(s)
  松下洋輔・Ili Syazwana Abdullah・高橋定子・小松正人・清谷一馬・吉丸哲郎・三好康雄・本田純子・紺谷桂一・大住省三・笹三徳・片桐豊雅
- Organizer
  日本人類遺伝学会第66回大会
- Data Source
  KAKENHI-PROJECT-21K07125
[Presentation] Frequent downregulation of SALL3 by genetic and epigenetic alterations is involved in progression and chemoresistance of triple negative breast cancers2019
- Author(s)
  Yosuke Matsushita, Masato Komatsu, Kazuma Kiyotani, Tetsuro Yoshimaru, Hiromu Suzuki, Yasuo Miyoshi, Mitsunori Sasa, Toyomasa Katagiri
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07200
[Presentation] トリプルネガティブ乳癌におけるがん抑制因子SALL3の不活化機構の解明2019
- Author(s)
  松下洋輔、小松正人、吉丸哲郎、井本逸勢、鈴木拓、片桐豊雅
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07200
[Presentation] The regulation of glutaminolysis via RHBDL2 is associated with malignant and chemoresistance in TNBC2019
- Author(s)
  Yosuke Matsushita, Kazumasa Okumura, Masato Komatsu, Ryuichiro Kimura, Tetsuro Yoshimaru, Masaya Ono, Junko Honda, Akira Tangoku, Yasuo Miyoshi, Mitsunori Sasa, Toyomasa Katagiri
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07200
[Presentation] The exploration of novel susceptibility genes associated with Japanese familial breast cancer by whole exome sequencing2019
- Author(s)
  松下洋輔・高橋定子・小松正人・清谷一馬・吉丸哲郎・三好康雄・本田純子・紺谷　桂一・大住省三・笹三徳・片桐豊雅
- Organizer
  日本人類遺伝学会第64回大会
- Data Source
  KAKENHI-PROJECT-18K07200
[Presentation] DDX31 cooperates with mutant p53 and EGFR to promote the multistep progression of invasive bladder cancer2018
- Author(s)
  Toyomasa Katagiri, Kei Daizumoto, Tetsuro Yoshimaru, Yosuke Matsushita, Tomoya Fukawa, Ono Masaya and Hiro-omi Kanayama
- Organizer
  American Association For Cancer Research ANNUAL MEETING 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19601
[Presentation] Overcoming trastuzumab resistance in HER2-overexpressing breast cancer by utilizing PHB2, a tumor suppressor of multiple resistance pathways2018
- Author(s)
  Tetsuro Yoshimaru, Yosuke Matsushita, Sasa Mitsunori, Miyoshi Yasuo and Toyomasa Katagiri
- Organizer
  American Association for Cancer Research ANNUAL MEETING 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] 新規Aキナーゼアンカータンパク質BIG3による抑制因子PHB2の制御はHER2乳癌細胞増殖に必須である2018
- Author(s)
  吉丸哲郎，松下洋輔，片桐豊雅
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K19601
[Presentation] DDX31 cooperates with mutant p53 and EGFR to promote the multistep progression of invasive bladder cancer2018
- Author(s)
  Toyomasa Katagiri, Kei Daizumoto, Tetsuro Yoshimaru, Yosuke Matsushita, Tomoya Fukawa, Ono Masaya and Hiro-omi Kanayama
- Organizer
  American Association For Cancer Research ANNUAL MEETING 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] BIG3-PKA-PP1Cα複合体による癌抑制因子PHB2不活性化を介したトラスツズマブ耐性乳癌増殖機構と新規治療法開発2018
- Author(s)
  吉丸哲郎, 松下洋輔, 笹三徳, 三好康雄, 片桐豊雅
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] 新規Aキナーゼアンカータンパク質BIG3による抑制因子PHB2の制御はHER2乳癌細胞増殖に必須である2018
- Author(s)
  吉丸哲郎，松下洋輔，片桐豊雅
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] Frequent downregulation of SALL3 by recurrent genetic and epigenetic alterations is involved in triple negative breast cancers2018
- Author(s)
  Yosuke Matsushita, Masato Komatsu, Kazuma Kiyotani, Tetsuro Yoshimaru, Hiromu Suzuki, Yasuo Miyoshi, Mitsunori Sasa and Toyomasa Katagiri
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07200
[Presentation] BIG3-PKA-PP1Cα複合体による癌抑制因子PHB2不活性化を介したトラスツズマブ耐性乳癌増殖機構と新規治療法開発2018
- Author(s)
  吉丸哲郎, 松下洋輔, 笹三徳, 三好康雄, 片桐豊雅
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K19601
[Presentation] トリプルネガティブ乳がんの包括的ゲノム解析2018
- Author(s)
  松下洋輔, 片桐豊雅
- Organizer
  第２回質量分析インフォマティクスハッカソンシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K07200
[Presentation] Downregulation of SALL3 by recurrent genetic and epigenetic alterations is involved in triple negative breast cancers2018
- Author(s)
  Yosuke Matsushita, Masato Komatsu, Kazuma Kiyotani, Tetsuro Yoshimaru, Takeshi Niinuma, Hiromu Suzuki, Junko Honda, Issei Imoto, Akira Tangoku, Yasuo Miyoshi, Mitsunori Sasa and Toyomasa Katagiri
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07200
[Presentation] Overcoming trastuzumab resistance in HER2-overexpressing breast cancer by utilizing PHB2, a tumor suppressor of multiple resistance pathways2018
- Author(s)
  Tetsuro Yoshimaru, Yosuke Matsushita, Sasa Mitsunori, Miyoshi Yasuo and Toyomasa Katagir
- Organizer
  American Association for Cancer Research ANNUAL MEETING 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19601
[Presentation] 内分泌療法耐性乳がんに対するBIG3-PHB2相互作用阻害ペプチドの開発2016
- Author(s)
  吉丸哲郎, 松下洋輔, 小松正人, 岡崎泰昌, 豊國伸哉, 笹三徳, 三好康雄, 片桐豊雅
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜　神奈川県横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] BIG3-PHB2相互作用を標的とした前立腺がん治療法の開発の可能性2016
- Author(s)
  瀧亮祐, 吉丸哲郎, 大豆本圭, 松下洋輔, 木村竜一朗, 尾野雅哉, 片桐豊雅
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜　神奈川県横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05153

1. KATAGIRI Toyomasa (60291895)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
2. 永橋昌幸 (30743918)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 凌一葦 (70804540)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. YOSHIMARU Tetsuro (80424729)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
5. ONO Masaya (00270900)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. MUZUGUCHI Kenji (50450896)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OTAKA Akira (20201973)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 三好康雄 (50283784)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 盛本浩二 (00599996)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. PRADIPTA AMBARA (90631648)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 文亜也子 (60936079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 樋口智子 (50786407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 阿部学 (10334674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 下田雅史 (30644455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Matsushita Yosuke 松下 洋輔

MATSUSHITA Yosuke 松下 洋輔

Research Projects

Research Products

Co-Researchers

脂質メディエーター分子機構の癌特異的阻害による乳癌新治療の実現へ向けた前臨床研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

TNBCにおける膜内在型セリンプロテアーゼRHBDL2の役割解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

乳癌患者由来オルガノイド・動物モデルの臨床的有用性の検証と新規治療開発への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of biomarkers and new treatments for metastatic breast cancer by eribulin

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel susceptibility genes and establishment of VUS risk assessment approach in Japanese familial breast cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of recurrent genetic and epigenetic alterations of SALL3 in TNBC by comprehensive genomic analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery in breast cancer utilizing reactivation of tumor suppressors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of novel pathophysiological roles of BIG3 in breast cancer cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening of small molecule compounds that inhibits interaction between PD-1 and PD-L1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A DDX31/mutant-p53/EGFR axis promotes multistep progression of muscle invasive bladder cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frequent downregulation of LRRC26 by epigenetic alterations is involved in the malignant progression of triple-negative breast cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 包括的ゲノム解析を通じた乳癌の発症・進展機構解明の現状と展望2017

Author(s)

Journal Title

Data Source

[Journal Article] Stapled BIG3 helical peptide ERAP potentiates antitumour activity for breast cancer therapeutics.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Stapled BIG3 helical peptide ERAP extends potent antitumor activity for breast cancer therapeutics2017

Matsushita Yosuke 松下洋輔

MATSUSHITA Yosuke 松下洋輔