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Kanji Horibe  堀部 寛治

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Horibe Kanji  堀部 寛治

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Researcher Number 70733509
Other IDs
Affiliation (Current) 2025: 松本歯科大学, 歯学部, 講師
Affiliation (based on the past Project Information) *help 2022 – 2024: 松本歯科大学, 歯学部, 講師
2014 – 2021: 松本歯科大学, 歯学部, 助教
2018: 松本歯科大学, 助教
Review Section/Research Field
Principal Investigator
Basic Section 57030:Conservative dentistry-related / Morphological basic dentistry / Basic Section 57040:Regenerative dentistry and dental engineering-related
Except Principal Investigator
Basic Section 57020:Oral pathobiological science-related / Basic Section 57040:Regenerative dentistry and dental engineering-related / Medium-sized Section 57:Oral science and related fields / Dental engineering/Regenerative dentistry / Basic Section 57060:Surgical dentistry-related / Functional basic dentistry / Basic Section 57010:Oral biological science-related
Keywords
Principal Investigator
歯科 / 骨再生 / 歯周組織 / 歯槽骨 / 歯周病 / 免疫学 / 細胞・組織 / 歯学 / IL-34 / 副甲状腺ホルモン関連タンパク … More / 歯周炎 / 組織再生 / 幹細胞 / 細胞系譜解析 / シグナル伝達 / サイトカイン / 免疫細胞 / 組織学 / 自然免疫 / 生体分子 … More
Except Principal Investigator
骨芽細胞 / Wnt / プロテオゲノミクス / 骨細胞 / 歯槽骨再生 / 抜歯窩治癒 / VDR / Ryk / マクロファージ / 歯髄組織 / 免疫組織化学 / Wntシグナル / 修復象牙質 / 歯髄 / M2マクロファージ / 骨吸収 / スクレロスチン / 破骨細胞 / マイクロCT / ビスホスホネート / 副甲状腺ホルモン関連タンパク / 副甲状腺ホルモン / 高ビタミンD症 / 慢性腎臓病 / 石灰化パラドクス / ビタミンD受容体 / IgG4関連疾患 / 分子擬態 / 細菌抗原 / 腫瘍免疫 / 骨髄 / 骨転移 / がん / 慢性腎臓病モデル / Ca・P代謝異常 / フレイル様病態 / 活性型ビタミンD / ゲノム編集スクリーニング / 骨再生制御因子 / ビタミンD / サイトカイン / 骨原生細胞 / RNAscope / TGF-b / 骨原性細胞 / 高感度レポーターシステム / Wnt活性レポーター / Crispr-A / リン酸化質量分析 / 骨形成 / 歯髄細胞 / プロテオミクス / 骨ミネラル代謝 / 加齢 / 細胞分化 / 細胞老化 / デンティンブリッジ / 組織幹細胞 / 歯髄再生療法 Less
  • Research Projects

    (19 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (24 People)
  •  Identification of factors responsible for Ca and P metabolic disease-associated frail-like phenotypes regulated by VDR in osteoblasts

    • Principal Investigator
      中道 裕子
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57020:Oral pathobiological science-related
    • Research Institution
      Matsumoto Dental University
  •  がん骨転移を制御する骨髄抗腫瘍免疫システムの解明

    • Principal Investigator
      平賀 徹
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57020:Oral pathobiological science-related
    • Research Institution
      Matsumoto Dental University
  •  Role of CSF-1R Ligand IL-34 in Immune Defense and Healing in Periodontal TissuePrincipal Investigator

    • Principal Investigator
      堀部 寛治
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Matsumoto Dental University
  •  Mechanism of IgG4-related disease pathogenesis caused by molecular mimicry of bacterial antigens.

    • Principal Investigator
      吉田 明弘
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57020:Oral pathobiological science-related
    • Research Institution
      Matsumoto Dental University
  •  Identification of a calcium paradox factor through transcriptomic and secretomic analysis of osteoblasts

    • Principal Investigator
      中道 裕子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 57:Oral science and related fields
    • Research Institution
      Matsumoto Dental University
  •  歯槽骨再生を促進する副甲状腺ホルモン・ビスホスホネート併用療法の開発

    • Principal Investigator
      中村 浩彰
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57040:Regenerative dentistry and dental engineering-related
    • Research Institution
      Matsumoto Dental University
  •  スクレロスチンによる破骨細胞の骨吸収制御機構の解明と新規骨吸収阻害薬の開発

    • Principal Investigator
      山下 照仁
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Matsumoto Dental University
  •  Elucidation of the role of PTHrP in alveolar bone regeneration and its application to regenerative dentistryPrincipal Investigator

    • Principal Investigator
      Horibe Kanji
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57040:Regenerative dentistry and dental engineering-related
    • Research Institution
      Matsumoto Dental University
  •  Identification of macrophage-derived bone regeneration factor and its application to alveolar bone regeneration

    • Principal Investigator
      Nakamura Hiroaki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57040:Regenerative dentistry and dental engineering-related
    • Research Institution
      Matsumoto Dental University
  •  Identification of regulators of bone regeneration using multiple modes of CRISPR-Cas9 genetic screens

    • Principal Investigator
      Nakamichi Yuko
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57040:Regenerative dentistry and dental engineering-related
    • Research Institution
      Matsumoto Dental University
  •  Development of bone anabolic drugs via evaluation of Wnt activity

    • Principal Investigator
      Nakamichi Yuko
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 57:Oral science and related fields
    • Research Institution
      Matsumoto Dental University
  •  Elucidation of the tissue stem cells that contribute to alveolar bone regeneration in micePrincipal Investigator

    • Principal Investigator
      Horibe Kanji
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Matsumoto Dental University
  •  Exploration of druggable targets for metabolic bone diseases using sensitive reporter systems and integrative proteogenomic approaches

    • Principal Investigator
      中道 裕子
    • Project Period (FY)
      2019 – 2024
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 57:Oral science and related fields
    • Research Institution
      Matsumoto Dental University
  •  Does aging of osteocytes adversely affect bone metabolism?

    • Principal Investigator
      yamashita teruhito
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57010:Oral biological science-related
    • Research Institution
      Matsumoto Dental University
  •  Tissue-resident macrophages in dental pulp regulate the microenvironment for reparative dentine formation

    • Principal Investigator
      Nakamura Hiroaki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dental engineering/Regenerative dentistry
    • Research Institution
      Matsumoto Dental University
  •  Research on mechanism of periodontitis exacerbation via regulation of T cell differentiation by hypoxia signalPrincipal Investigator

    • Principal Investigator
      Horibe Kanji
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Matsumoto Dental University
  •  Roles of an atypical Wnt receptor, Ryk, for bone formation and mineral metabolism

    • Principal Investigator
      Nakamichi Yuko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Matsumoto Dental University
  •  Role of M2 macrophages in reparative dentin formation and development of new endodontic regerative treatment

    • Principal Investigator
      NAKAMURA Hiroaki
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Dental engineering/Regenerative dentistry
    • Research Institution
      Matsumoto Dental University
  •  Analyse the effects of antimicrobe peptide Cathelicidin on dental pulp repair.Principal Investigator

    • Principal Investigator
      Horibe Kanji
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Matsumoto Dental University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

  • [Journal Article] RANKL/OPG ratio regulates odontoclastogenesis in damaged dental pulp2021

    • Author(s)
      Daisuke Nishida , Atsushi Arai , Lijuan Zhao , Mengyu Yang , Yuko Nakamichi , Kanji Horibe , Akihiro Hosoya , Yasuhiro Kobayashi , Nobuyuki Udagawa , Toshihide Mizoguchi
    • Journal Title

      Scientific reports

      Volume: 11(1) Issue: 1 Pages: 4575-4575

    • DOI

      10.1038/s41598-021-84354-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K24156, KAKENHI-PROJECT-19K10171, KAKENHI-PROJECT-19K22727, KAKENHI-PROJECT-20H03853, KAKENHI-PROJECT-20H03872, KAKENHI-PROJECT-20K20394, KAKENHI-PROJECT-19K22728, KAKENHI-PROJECT-20K21689, KAKENHI-PROJECT-21K19615, KAKENHI-PROJECT-19KK0234, KAKENHI-PROJECT-23K21488
  • [Journal Article] The Vitamin D Receptor in Osteoblast-Lineage Cells Is Essential for the Proresorptive Activity of 1α,25(OH)2D3 In Vivo2020

    • Author(s)
      Tomoki Mori, Kanji Horibe, Masanori Koide, Shunsuke Uehara, Yoko Yamamoto, Shigeaki Kato, Hisataka Yasuda, Naoyuki Takahashi, Nobuyuki Udagawa, Yuko Nakamichi
    • Journal Title

      Endocrinology .

      Volume: 161 Issue: 11 Pages: 1-14

    • DOI

      10.1210/endocr/bqaa178

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10050, KAKENHI-PROJECT-19K22728, KAKENHI-PROJECT-19K22729, KAKENHI-PROJECT-20K21689, KAKENHI-PROJECT-19KK0234, KAKENHI-PROJECT-18H02980, KAKENHI-PROJECT-20H03872
  • [Journal Article] VDR in osteoblast-lineage cells primarily mediates vitamin D treatment-iInduced increase in bone mass by suppressing bone resorption.2017

    • Author(s)
      Nakamichi Y, Udagawa N, Horibe K, Mizoguchi T, Yamamoto Y, Nakamura T, Hosoya A, Kato S, Suda T, Takahashi N
    • Journal Title

      J Bone Miner Res

      Volume: 32 Issue: 6 Pages: 1297-1308

    • DOI

      10.1002/jbmr.3096

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05144, KAKENHI-PROJECT-26462826, KAKENHI-PROJECT-16K11493, KAKENHI-PROJECT-16K11664, KAKENHI-PROJECT-16K11818, KAKENHI-PROJECT-17K19776, KAKENHI-PROJECT-15KK0356, KAKENHI-PROJECT-16H05508, KAKENHI-PROJECT-17H04374, KAKENHI-PROJECT-15K11093
  • [Presentation] 歯周炎後のマウス歯周組織へのPTHrP 局所投与の効果2023

    • Author(s)
      堀部寛治、西田大輔、中村浩彰
    • Organizer
      第65回歯科基礎医学会学術大会
    • Data Source
      KAKENHI-PROJECT-23K09241
  • [Presentation] 歯周炎後のマウス歯周組織への PTHrP局所投与の効果2023

    • Author(s)
      堀部寛治、西田大輔、中村浩彰
    • Organizer
      第65回歯科基礎医学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K09965
  • [Presentation] 歯周組織治癒過程における PTHrP および PTH1 受容体の遺伝子発現2022

    • Author(s)
      堀部寛治、西田大輔、中村浩彰
    • Organizer
      第64回歯科基礎医学会学術大会
    • Data Source
      KAKENHI-PROJECT-20K10022
  • [Presentation] 歯周組織治癒過程における PTHrP および PTH1 受容体の遺伝子発現2022

    • Author(s)
      堀部 寛治、西田 大輔、中村 浩彰
    • Organizer
      第64回歯科基礎医学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K09965
  • [Presentation] マウスの抜歯後治癒におけるマクロファージ枯渇の影響2021

    • Author(s)
      堀部寛治、西田大輔、中村浩彰
    • Organizer
      第63回歯科基礎医学会学術大会
    • Data Source
      KAKENHI-PROJECT-20K10022
  • [Presentation] RANKL/OPG比は損傷した歯髄における破歯細胞形成を調節する2021

    • Author(s)
      西田大輔,荒井敦,堀部寛治,中道裕子,細矢明宏,中村浩彰,小林泰浩,宇田川信之,溝口利英
    • Organizer
      第39回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-19KK0234
  • [Presentation] RANKL/OPG比は損傷した歯髄における破歯細胞形成を調節する2021

    • Author(s)
      西田大輔,荒井敦,堀部寛治,中道裕子,細矢明宏,中村浩彰,小林泰浩,宇田川信之,溝口利英
    • Organizer
      第39回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K22728
  • [Presentation] RANKL/OPG比は損傷した歯髄における破歯細胞形成を調節する2021

    • Author(s)
      西田大輔,荒井敦,堀部寛治,中道裕子,細矢明宏,中村浩彰,小林泰浩,宇田川信之,溝口利英
    • Organizer
      第39回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H03872
  • [Presentation] 抜歯窩治癒過程における M2 様マクロファージ浸潤と TGF-b分泌2020

    • Author(s)
      堀部 寛治 ,原 弥勒力 ,中村 浩彰
    • Organizer
      第62回歯科基礎医学会学術大会
    • Data Source
      KAKENHI-PROJECT-20K10022
  • [Presentation] BMP 誘導性の異所性骨における骨形成抑制因子スクレロスチン陽性細胞の経時的観察2020

    • Author(s)
      松下雅衣,小出雅則,芳澤享子,堀部寛治,小林泰浩,山下照仁,中道裕子, 上原俊介,宇田川信之
    • Organizer
      第62回歯科基礎学会学術大会
    • Data Source
      KAKENHI-PROJECT-20H03872
  • [Presentation] 活性型ビタミンD3のin vivo大量投与による骨吸収促進と血清Ca値上昇作用は、骨芽細胞のVDRを介する2020

    • Author(s)
      森 智紀,堀部寛治,小出雅則,高橋直之,宇田川信之,中道裕子
    • Organizer
      第5回 日本骨免疫学会ウインタースクール
    • Data Source
      KAKENHI-PROJECT-19KK0234
  • [Presentation] BMP 誘導性の異所性骨における骨形成抑制因子スクレロスチン陽性細胞の経時的観察2020

    • Author(s)
      松下雅衣,小出雅則,芳澤享子,堀部寛治,小林泰浩,山下照仁,中道裕子, 上原俊介,宇田川信之
    • Organizer
      第38回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-19KK0234
  • [Presentation] 活性型ビタミンD3のin vivo大量投与による骨吸収促進と血清Ca値上昇作用は、骨芽細胞のVDRを介する2020

    • Author(s)
      森 智紀,堀部寛治,小出雅則,高橋直之,宇田川信之,中道裕子
    • Organizer
      第5回 日本骨免疫学会ウインタースクール
    • Data Source
      KAKENHI-PROJECT-19K22728
  • [Presentation] BMP 誘導性の異所性骨における骨形成抑制因子スクレロスチン陽性細胞の経時的観察2020

    • Author(s)
      松下雅衣,小出雅則,芳澤享子,堀部寛治,小林泰浩,山下照仁,中道裕子, 上原俊介,宇田川信之
    • Organizer
      歯科基礎学会学術大会 (第62回)
    • Data Source
      KAKENHI-PROJECT-18K09531
  • [Presentation] BMP 誘導性の異所性骨における骨形成抑制因子スクレロスチン陽性細胞の経時的観察2020

    • Author(s)
      松下雅衣,小出雅則,芳澤享子,堀部寛治,小林泰浩,山下照仁,中道裕子, 上原俊介,宇田川信之
    • Organizer
      第62回歯科基礎学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K22728
  • [Presentation] Wnt/β-cateninシグナルの制御系をモニターするSost-Greenレポーターマウスの作出2019

    • Author(s)
      山下照仁,小出雅則,堀部寛治,上原俊介,宇田川信之,高橋直之,中村浩彰,小林泰浩
    • Organizer
      第88回松本歯科大学学会総会
    • Data Source
      KAKENHI-PROJECT-18K09531
  • [Presentation] 修復象牙質形成過程における古典的Wntシグナル組織学的検討2019

    • Author(s)
      原弥革力、堀部寛治、平賀徹、中村浩彰
    • Organizer
      第88回松本歯科大学学会
    • Data Source
      KAKENHI-PROJECT-17H04400
  • [Presentation] 古典的Wntシグナルによるデンティンブリッジ形成過程の解析2019

    • Author(s)
      原弥革力、堀部寛治、平賀徹、中村浩彰
    • Organizer
      第61回歯科基礎医学会学術大会
    • Data Source
      KAKENHI-PROJECT-17H04400
  • [Presentation] 修復象牙質形成過程における古典的Wntシグナルの関与2018

    • Author(s)
      原弥革力、堀部寛治、平賀徹、中村浩彰
    • Organizer
      オーラルサイエンス研究会
    • Data Source
      KAKENHI-PROJECT-17H04400
  • [Presentation] デンティンブリッジ形成過程における古典的Wntシグナルの役割2018

    • Author(s)
      原弥革力、堀部寛治、平賀徹、中村浩彰
    • Organizer
      歯科基礎医学会
    • Data Source
      KAKENHI-PROJECT-17H04400
  • [Presentation] VDR in osteoblast-lineage cells primarily mediates a 1a,25(OH)2D3 derivative-induced increase in bone mass by suppressing bone resorption.2017

    • Author(s)
      Nakamichi Y, Udagawa N, Horibe K, Mizoguchi T, Yamamoto Y, Nakamura T, Hosoya A, Kato S, Suda T, and Takahashi N.
    • Organizer
      第20回ビタミンDワークショップ
    • Place of Presentation
      Rosen Centre (米国フロリダ州オランド)
    • Year and Date
      2017-03-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11493
  • [Presentation] ビタミンDの骨量増加の薬理作用は、破骨細胞ではなく骨芽細胞のVDRを介する2016

    • Author(s)
      中道裕子,溝口利英, 山本陽子, 中村貴、細矢明宏, 堀部寛治, 原田卓, 斎藤一史, 加藤茂明, 須田立雄, 宇田川信之, 高橋直之
    • Organizer
      第34回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-07-20
    • Data Source
      KAKENHI-PROJECT-16K11493
  • [Presentation] 抗微生物ペプチドcathelicidinの象牙質修復に対する促進的関与2015

    • Author(s)
      堀部寛治,細矢明宏,平賀 徹,中村浩彰
    • Organizer
      第57回 歯科基礎医学会学術大会
    • Place of Presentation
      〒950-0078 新潟県新潟市中央区万代島6-1 朱鷺メッセ 新潟コンベンションセンター
    • Year and Date
      2015-09-11
    • Data Source
      KAKENHI-PROJECT-26893301
  • [Presentation] 抗微生物ペプチドcathelicidinの象牙質修復に対する促進的関与2015

    • Author(s)
      堀部寛治,細矢明宏,平賀 徹,中村浩彰
    • Organizer
      第33回 日本骨代謝学会学術集会
    • Place of Presentation
      〒160-8330 東京都新宿区西新宿2-2-1 京王プラザホテル
    • Year and Date
      2015-07-23
    • Data Source
      KAKENHI-PROJECT-26893301
  • [Presentation] ラット歯・歯周組織におけるformyl peptide receptor 2(Fpr2)の局在

    • Author(s)
      堀部寛治、細矢明宏、平賀徹、中村浩彰
    • Organizer
      第56回 歯科基礎医学会学術大会
    • Place of Presentation
      福岡国際会議場(〒812-0032 福岡県福岡市博多区石城町2-1)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26893301
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