yamashita teruhito 山下照仁

… Alternative Names

YAMASHITA Teruhito 山下照仁

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Researcher Number	90302893
Other IDs
External Links
Affiliation (Current)	2023: 松本歯科大学, 総合歯科医学研究所, 准教授
Affiliation (based on the past Project Information) *help	2023: 松本歯科大学, 付置研究所, 准教授 2013 – 2022: 松本歯科大学, 総合歯科医学研究所, 准教授 2015: 松本歯科大学, 総合歯科研究所, 准教授 2014: 松本歯科大学, 付置研究所, 准教授 2005 – 2012: Institute for Oral Science, Assistant Professor, 総合歯科医学研究所, 講師 … More 2009: 総合歯科医学研究所, 講師 2004: 松本歯科大学, 歯学部, 講師 1998 – 2001: 東京医科歯科大学, 難治疾患研究所, 助手 Less
Review Section/Research Field	Principal Investigator Functional basic dentistry / Orthopaedic surgery / Basic Section 57010:Oral biological science-related / Basic Section 57060:Surgical dentistry-related Except Principal Investigator Functional basic dentistry / Orthopaedic surgery / Orthodontic/Pediatric dentistry / Medium-sized Section 57:Oral science and related fields / Orthodontics/Pediatric dentistry / Basic Section 57070:Developmental dentistry-related … More / 矯正・小児・社会系歯学 / Biological Sciences / Biomedical engineering/Biological material science / Applied health science / Surgical dentistry / Basic Section 57040:Regenerative dentistry and dental engineering-related / Basic Section 56020:Orthopedics-related / Basic Section 57020:Oral pathobiological science-related Less
Keywords	Principal Investigator 骨吸収 / 破骨細胞 / MAPキナーゼ / 骨細胞 / 細胞分化 / klotho / OCIF / OPG / 骨大理石病 / ノックアウトマウス … More / 骨形態評価 / μCT / klotho遺伝子変異マウス / OCIF遺伝子破壊マウス / 二重変異マウス / 骨形成 / 骨髄除去 / 天然有機化合物 / 抗癌剤 / 抗がん剤 / 転写因子 / NFATc1 / リン酸化 / 天然化合物 / 質量分析 / 延命 / 酵母ツーハイブリッド / p38 MAPキナーゼ / MKK6 / アデノウイルスベクター / osteoclasts / MAP kinase / bone resorption / survival / Yeast Two Hybrid Screening / 骨芽細胞 / 脂肪細胞 / 細胞老化 / 加齢 … More Except Principal Investigator 破骨細胞 / 骨芽細胞 / 骨吸収 / 骨形成 / RANKL / オステオポンチン / BMP / 転写因子 / 骨粗鬆症 / スクレロスチン / 骨代謝カップリング / ノックアウトマウス / M-CSF / RANK / Wnt / Wnt5a / 骨代謝回転 / 歯周病 / SOD / 軟骨細胞 / 骨細胞 / オステオプロテゲリン / Siglec-15 / CBFA / メカニカルストレス / がん転移 / OPG / 骨誘導因子 / 破骨細胞前駆細胞 / 歯槽骨 / リポ多糖 / 骨 / アネキシンA5 / 金属酵素 / 部位特異的変異 / 金属選択性 / Tob / Osteoclast / Cbfa1 / CIZ / LPS / CD14 / MyD88 / PKC / TRIF / Cre recombinase / 骨代謝 / 骨リモデリング / 機械的刺激 / Smad / 細胞分化 / 歯牙 / 骨転移 / 肺転移 / インテグリン / 動脈性転移 / 静脈性転移 / 膜透過性 / 融合蛋白 / 時間軸 / 融合タンパク / カーボンナノチューブ / NFATc1 / エピタキシー / 破骨細胞前駆細胞(QuOPs) / 破骨細胞前駆(QuOPs) / エピジェネティック解析 / 大理石骨病 / サイトカイン / 歯科矯正学 / 骨芽細胞特異的遺伝子欠損 / 歯の移動 / 加齢 / コンディショナルノックアウト / 口腔粘膜 / Toll-like受容体 / マクロファージ / Annexin a5 / 腱 / 靭帯 / 歯周病原菌 / 酵素 / 遺伝子制御 / klotho / 細胞外基質分子・オステオポンチン / 骨形成因子 / 老化関連遺伝子 / MITF / Osteoporosis / Osteoblast / Gene Regulation / Osteopontin / Klotho / Mechanical Stress / 骨髄除去 / 老化 / エストロゲン / 病態生理学 / osteopontin / knockout mouse / bone resorption / osteoclasts / bone formation / osteoblasts / osteoporosis / bone marrow ablatior / シグナル / 骨髄 / 前駆細胞 / プロモーター / 転写 / 細胞接着 / 骨再生 / 骨髄幹細胞 / Cbfa / プロモーター解析 / osteoblast / osteoclast / signal / bone marrow / progenitor / 活性酸素 / スーパーオキシドジスムターゼ / 酸化還元酵素 / Porphyromonas gingivalis / Reactive oxygen / cambialistic enzyme / Metallo enzyme / Oxidoreductase / Porphyromanas gingivalis / site-directed mutagenesis / EPR spectrum / ヒト破骨細胞 / 歯周疾患 / 破骨細胞分化因子 / ペプチドグリカン / ムラミルジペプチド / Creリコンビナーゼ / 歯周組織 / ノックインマウス / COX2 / BACクローン / 相同組み換え / orthodontics / osteoclast precursors / ドセタキセル / 微小管 / DOCETAXEL / BONE RESORPTION / OSTEOBLAST / OSTEOCLAST / MICROTUBULES / カルシトニン / カモノハシ / オポッサム / アクチンリング / カルシトニン受容体 / Sfrp5 / 骨量 / 骨改造 / Pkn3 / Ｗｎｔ５ａ / Ｓｆｒｐ５ / 歯学 / 遺伝子 / 動物 / 骨誘導因子（BMP) / 異所性骨 / 成長発育 / 石灰化 / 骨カップリング / 骨代謝共役 / 骨代謝―脱共役 / 脱共役因子 / 心肥大 / 高血圧 / アンジオテンシンⅡ / ペリオスチン / 心臓血管疾患 / LIF / 続発性骨粗鬆症 / 造血幹細胞ニッチ / 間葉系幹細胞 / シグナル伝達 / 免疫学 / 糖鎖 / Wntシグナル Less

スクレロスチンによる破骨細胞の骨吸収制御機構の解明と新規骨吸収阻害薬の開発Principal Investigator
- Principal Investigator
  
  山下照仁
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Matsumoto Dental University
Elucidation of the mechanism of action of Siglec-15 antibody drugs in the treatment of secondary osteoporosis during growth and development
- Principal Investigator
  
  中村美どり
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Matsumoto Dental University
スクレロスチンによる造血幹細胞ニッチおよび間葉系幹細胞の調節機構の解明
- Principal Investigator
  
  小出雅則
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Matsumoto Dental University
Anlysis of the RANKL-Siglec-15 signal molecular mechanism for alveolar bone regeneration
- Principal Investigator
  
  宇田川信之
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Matsumoto Dental University
破骨細胞におけるDAP12を介したITAMシグナル経路を制御する分子機構の解明
- Principal Investigator
  
  北川教弘
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Nara Institute of Science and Technology
骨特異的Wntシグナル阻害分子スクレロスチンの臓器選択的がん転移に対する制御機構
- Principal Investigator
  
  平賀徹
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Matsumoto Dental University
Elucidation of unknown network mechanism of osteoprotegerin in bone, cardiovascular and digestive system
- Principal Investigator
  
  宇田川信之
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Matsumoto Dental University
Elucidation of the role of sclerostin in growth and development process of bone
- Principal Investigator
  
  Nakamura Midori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Matsumoto Dental University
Development of new therapeutic agents for bone and periodontal diseases based on the bone metabolism-uncoupling mechanisms
- Principal Investigator
  
  Koide Masanori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Matsumoto Dental University
Does aging of osteocytes adversely affect bone metabolism?Principal Investigator
- Principal Investigator
  
  yamashita teruhito
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Matsumoto Dental University
マウスモデルを用いたブラキシズム発症におけるアネキシンA5の機能解析
- Principal Investigator
  
  島田明美
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tsurumi University
Development of alveolar bone turnover control method based on Wnt signaling network
- Principal Investigator
  
  Kobayashi Yasuhiro
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Matsumoto Dental University
Investigation of factors determining terminal differentiation into osteocytesPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Teruhito
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Matsumoto Dental University
Did calcitonine appear as a central nerve hormone?
- Principal Investigator
  
  Udagawa Nobuyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Matsumoto Dental University
Regulation of bone remodeling by Annexin A5 at tendon/ligament insertion sites
- Principal Investigator
  
  Shimada Akemi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tsurumi University
Development of antibacterial agents of periodontal pathogens : a basic study
- Principal Investigator
  
  HIRAOKA Yukihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied health science
- Research Institution
  Matsumoto Dental University
Development of alveolar bone turnover control method based on Wnt5a
- Principal Investigator
  
  Kobayashi Yasuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Matsumoto Dental University
Novel mechanism of regulating the activity of the transcription factor NFATc1 in bone metabolismPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Teruhito
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Matsumoto Dental University
Analysis of roles of Wnt5a in alveolar bone remodeling, and their application for orthodontic tooth movement.
- Principal Investigator
  
  KOBAYASHI Yasuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Matsumoto Dental University
Elucidation of the novel inhibitory mechanism of anti-tumor drug arctigenin on bone resorptionPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Teruhito
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Matsumoto Dental University
LPSシグナルを用いた口腔粘膜疾患モデルの開発
- Principal Investigator
  
  中村浩志
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Matsumoto Dental University
Analysis of molecular mechanism of carbon nanotube regulating bone metabolism
- Principal Investigator
  
  MIZOGUCHI Toshihide
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Functional basic dentistry
  Biomedical engineering/Biological material science
- Research Institution
  Matsumoto Dental University
破骨細胞が分泌する新規骨形成誘導因子の同定
- Principal Investigator
  
  宇田川信之
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Matsumoto Dental University
Analysis of novel MAP kinase binding factor which regulates osteoclastsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Teruhito
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Matsumoto Dental University
転写因子AP-1やNF-κBと協奏的に働く破骨細胞の分化因子のクローニング
- Principal Investigator
  
  宮沢裕夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Matsumoto Dental University
Application of Cre-loxP system for elucidation of mechanisms in bone remodeling during tooth movement
- Principal Investigator
  
  KOBAYASHI Yasuhiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Matsumoto Dental University
Docetaxel inhibits bone resorption through suppression of osteoclast formation and fuction in different manners
- Principal Investigator
  
  TAKAHASHI Masahiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Matsumoto Dental University
Establishment of periodontitis treatment method by inhibition of RANK-Toll like receptor signal
- Principal Investigator
  
  UDAGAWA Nobuyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Matsumoto Dental University
Analysis of p38 MAP kinase pathway in osteoclastsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Teruhito
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Matsumoto Dental University
A change of the metal-specific active site structure of superoxide dismutase from Porphyromonas gingivalis by the mutation of Gly155Thr.
- Principal Investigator
  
  HIRAOKA B.Yukihiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Matsumoto Dental University
癌転移におけるαvβ3インテグリン・結合分子オステオポンチンの機能解析
- Principal Investigator
  
  野田政樹
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Cbfa1 promoter regulation in bone cells and its application for regeneration
- Principal Investigator
  
  NODA Masaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Dental and Medical University
Klotho遺伝子及びOCIF遺伝子のダブルノックアウトマウスによる骨代謝の研究Principal Investigator
- Principal Investigator
  
  山下照仁
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
オステオポンチン・ノックアウト動物の歯牙の移動によるメカニカルストレスへの応答性
- Principal Investigator
  
  野田政樹
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  矯正・小児・社会系歯学
- Research Institution
  Tokyo Medical and Dental University
機能的刺激によるCBFA遺伝子の制御に関わる骨芽細胞のBMPシグナル伝達機構
- Principal Investigator
  
  NODA Masaki
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Pathophysiological study on Osteoporosis using Osteopontin-Knock out mice
- Principal Investigator
  
  NODA Masaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
Analyses of Molecular Mechanisms Involved in Pathogenesis of 0steoporosis
- Principal Investigator
  
  NODA Masaki
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical Dental University

[Book] 副甲状腺・骨代謝疾患診療マニュアル, 改訂第2版2019
- Author(s)
  山下照仁, 小出雅則，高橋直之 (分担執筆)
- Total Pages
  3
- Publisher
  診断と治療社
- ISBN
- Data Source
  KAKENHI-PROJECT-19K22729
[Book] Identification of osteoclasts in culture2011
- Author(s)
  Udagawa N, Yamashita T, Kobayashi Y, Takahashi N, Nicole I zur Nieden
- Publisher
  Springer Science
- Data Source
  KAKENHI-PROJECT-21390551
[Book] Identification of osteoclasts in culture. In Embryonic Stem Cell Therapy for Osteo-Degenerative Diseases Series Methods in Molecular Biology2011
- Author(s)
  Udagawa N, Yamashita T, Kobayashi Y, Takahashi N, Walker JM, zur Nieden NI
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-21592378
[Journal Article] Evidence for the major contribution of remodeling-based bone formation in sclerostin-deficient mice.2022
- Author(s)
  Koide M, Yamashita T, Nakamura K, Yasuda H, Udagawa N, Kobayashi Y
- Journal Title
  
  Bone
  
  Volume: 160 Pages: 116401-116401
- DOI
  10.1016/j.bone.2022.116401
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21689
[Journal Article] Angiotensin II Induces Aortic Rupture and Dissection in Osteoprotegerin‐Deficient Mice2022
- Author(s)
  Tsuruda T, Yamashita A, Otsu M, Koide M, Nakamichi Y, Sekita-Hatakeyama Y, Hatakeyama K, Funamoto T, Chosa E, Asada Y, Udagawa N, Kato J, Kitamura K
- Journal Title
  
  J Am Heart Assoc
  
  Volume: 11
- DOI
  10.1161/jaha.122.025336
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08521, KAKENHI-PROJECT-20H03872, KAKENHI-PROJECT-19K22728, KAKENHI-PROJECT-20K21689, KAKENHI-PROJECT-19KK0234
[Journal Article] Osteoclast differentiation by RANKL and OPG signaling pathways.2021
- Author(s)
  Udagawa Nobuyuki、Koide Masanori、Nakamura Midori、Nakamichi Yuko、Yamashita Teruhito、Uehara Shunsuke、Kobayashi Yasuhiro、Furuya Yuriko、Yasuda Hisataka、Fukuda Chie、Tsuda Eisuke
- Journal Title
  
  J Bone Miner Metab
  
  Volume: 39 Pages: 19-26
- DOI
  10.1007/s00774-020-01162-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20394, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-17H01584, KAKENHI-PROJECT-19K10050, KAKENHI-PROJECT-19K10395, KAKENHI-PROJECT-19K22729, KAKENHI-PROJECT-20H03872, KAKENHI-PROJECT-21H03125, KAKENHI-PROJECT-19K22728, KAKENHI-PROJECT-20K21689, KAKENHI-PROJECT-19KK0234
[Journal Article] Sclerostin expression in trabecular bone is downregulated by osteoclasts2020
- Author(s)
  Masanori Koide, Teruhito Yamashita, Kohei Murakami, Shunsuke Uehara, Keigo Nakamura, Midori Nakamura, Mai Matsushita, Toshiaki Ara, Hisataka Yasuda, Josef M Penninger, Naoyuki Takahashi, Nobuyuki Udagawa, Yasuhiro Kobayashi
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 13751-13751
- DOI
  10.1038/s41598-020-70817-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10050, KAKENHI-PROJECT-19K10395, KAKENHI-PROJECT-19K22729, KAKENHI-PROJECT-20K21689, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-17H01584, KAKENHI-PROJECT-18H02980, KAKENHI-PROJECT-18K09531, KAKENHI-PROJECT-19K18955
[Journal Article] 新型コロナウイルスの抗体検査を用いた松本歯科大学学生・教職員の疫学調査2020
- Author(s)
  前島信也, 宇田川信之, 中西正人, 中村美どり, 山賀孝之, 山下照仁, 川茂幸, 矢ヶ﨑雅
- Journal Title
  
  医学のあゆみ
  
  Volume: 274 Pages: 393-395
- NAID
  40022289088
- Data Source
  KAKENHI-PROJECT-19K10395
[Journal Article] A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro2017
- Author(s)
  Murakami K, Kobayashi Y, Uehara S, Suzuki T, Koide M, Yamashita T, Nakamura M, Takahashi N, Kato H, Udagawa N and Nakamura Y
- Journal Title
  
  PLoS One
  
  Volume: 12
- DOI
  10.1371/journal.pone.0181126
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11494, KAKENHI-PROJECT-17K16686, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-16H05144, KAKENHI-PROJECT-15K11028, KAKENHI-PROJECT-15K11377, KAKENHI-PROJECT-15K11401
[Journal Article] Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts2017
- Author(s)
  Koide M, Kobayashi Y, Yamashita T, Uehara S, Nakamura M, Hiraoka BY, Ozaki Y, Iimura T, Yasuda H, Takahashi N and Udagawa N
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: 32 Pages: 2074-2086
- DOI
  10.1002/jbmr.3175
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11494, KAKENHI-PROJECT-26293392, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-16H05144, KAKENHI-PROJECT-15K11028, KAKENHI-PROJECT-15K11059, KAKENHI-PROJECT-15K11377, KAKENHI-PROJECT-15K11401, KAKENHI-PROJECT-15K11402
[Journal Article] Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling2017
- Author(s)
  Uehara S, Udagawa N, Mukai H, Ishihara A, Maeda K, Yamashita T, Murakami K, Nishita M, Nakamura T, Kato S, Minami Y, Takahashi N and Kobayashi Y
- Journal Title
  
  Sci. Signaling
  
  Volume: 10
- DOI
  10.1126/scisignal.aan0023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11494, KAKENHI-PROJECT-16K11818, KAKENHI-PROJECT-17K07168, KAKENHI-PROJECT-17K08634, KAKENHI-PROJECT-17K19776, KAKENHI-PROJECT-17K16686, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-16H05144, KAKENHI-PROJECT-16H05152, KAKENHI-PROJECT-16H05508, KAKENHI-PROJECT-15K11059, KAKENHI-PROJECT-15K11377
[Journal Article] Platypus and opossum calcitonins exhibit strong activities, even though they belong to mammals.2017
- Author(s)
  Yamashita T, Udagawa N, Thirukonda GJ, Uehara S, Yamauchi H, Suzuki N, Li F, Kobayashi Y, Takahashi N.
- Journal Title
  
  Gen Comp Endocrinol
  
  Volume: 246 Pages: 270-278
- DOI
  10.1016/j.ygcen.2017.01.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462825, KAKENHI-PROJECT-15K15688, KAKENHI-PROJECT-15K11059, KAKENHI-PROJECT-16K11494, KAKENHI-PROJECT-16K11818, KAKENHI-PROJECT-17K19776, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-16H05144, KAKENHI-PROJECT-16H05508
[Journal Article] The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts2016
- Author(s)
  Thirukonda GJ, Uehara S, Nakayama T, Yamashita T, Nakamura Y, Mizoguchi T, Takahashi N, Yagami K, Udagawa N, Kobayashi Y.
- Journal Title
  
  J Bone Miner Metab
  
  Volume: 34 Pages: 395-405
- DOI
  10.1007/s00774-015-0683-1
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462825, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-16H05144, KAKENHI-PROJECT-26462826, KAKENHI-PROJECT-15K11059, KAKENHI-PROJECT-16K11664
[Journal Article] Luman, an ER membrane-bound transcription factor, is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization.2015
- Author(s)
  Kanemoto S, Kobayashi Y, Yamashita T, Miyamoto T, Cui M, Asada R, Cui X, Hino K, Kaneko M, Takai T, Matsuhisa K, Takahashi N, Imaizumi K.
- Journal Title
  
  Journal of Cell Science
  
  Volume: 128 Pages: 4353-4365
- DOI
  10.1242/jcs.176057
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462825, KAKENHI-PROJECT-15K19516, KAKENHI-PROJECT-15K20001, KAKENHI-PROJECT-25221310, KAKENHI-PROJECT-25251014, KAKENHI-PROJECT-13J00677, KAKENHI-PROJECT-26670814, KAKENHI-PROJECT-15K18377, KAKENHI-PROJECT-15K21706
[Journal Article] High-performance scaffolds on titanium surfaces: osteoblast differentiation and mineralization promoted by a globular fibrinogen layer through cell-autonomous BMP signaling.2015
- Author(s)
  Horasawa N, Yamashita T, Uehara S, Udagawa N
- Journal Title
  
  Mater Sci Eng C Mater Biol
  
  Volume: 46 Pages: 86-96
- DOI
  10.1016/j.msec.2014.10.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11059, KAKENHI-PROJECT-26462825, KAKENHI-PROJECT-15K15688
[Journal Article] Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a2015
- Author(s)
  Kobayashi Y, Thirukonda GJ, Nakamura Y, Koide M, Yamashita T, Uehara S, Kato H, Udagawa N, Takahashi N
- Journal Title
  
  Biochem Biopys Res Commun
  
  Volume: 463 Pages: 1278-1283
- DOI
  10.1016/j.bbrc.2015.06.102
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11059, KAKENHI-PROJECT-15K11401, KAKENHI-PROJECT-26462825, KAKENHI-PROJECT-26462826, KAKENHI-PROJECT-15K15688, KAKENHI-PROJECT-25221310, KAKENHI-PROJECT-25462904, KAKENHI-PROJECT-25462905, KAKENHI-PROJECT-26670814, KAKENHI-PROJECT-25293423
[Journal Article] The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts.2015
- Author(s)
  Thirukonda GJ, Uehara S, Nakayama T, Yamashita T, Nakamura Y, Mizoguchi T, Takahashi N, Yagami K, Udagawa N, Kobayashi Y
- Journal Title
  
  J Bone Miner Metab
  
  Volume: -
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15688
[Journal Article] Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways2014
- Author(s)
  Yamashita T, Uehara S, Udagawa N, Li F, Kadota S, Esumi H, Kobayashi Y, Takahashi N
- Journal Title
  
  PLOS ONE
  
  Volume: 9 Pages: 1-12
- DOI
  10.1371/journal.pone.0085878
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23593054, KAKENHI-PROJECT-24390417, KAKENHI-PROJECT-24592821, KAKENHI-PROJECT-24659833, KAKENHI-PROJECT-25221310, KAKENHI-PROJECT-25293423, KAKENHI-PROJECT-25462904, KAKENHI-PROJECT-25670792, KAKENHI-PROJECT-25670793, KAKENHI-PROJECT-26462825, KAKENHI-PROJECT-26670814
[Journal Article] Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteoblastogenesis.2014
- Author(s)
  Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
- Journal Title
  
  Ｓｃｉ　Ｒｅｐ
  
  Volume: 4 Pages: 137-146
- DOI
  10.1038/srep04493
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23112007, KAKENHI-PROJECT-23593054, KAKENHI-PROJECT-23791668, KAKENHI-PROJECT-24240076, KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-24390080, KAKENHI-PROJECT-24390417, KAKENHI-PROJECT-24592821, KAKENHI-PROJECT-24659833, KAKENHI-PROJECT-25221310, KAKENHI-PROJECT-25293423, KAKENHI-PROJECT-25462385, KAKENHI-PROJECT-25462904, KAKENHI-PROJECT-25462905, KAKENHI-PROJECT-25670792, KAKENHI-PROJECT-25670793, KAKENHI-PROJECT-26462825, KAKENHI-PROJECT-26670814
[Journal Article] New roles of osteoblasts involved in osteoclast differentiation2012
- Author(s)
  Yamashita T, Takahashi N, Udagawa N
- Journal Title
  
  World Journal of Orthopedics
  
  Volume: 3 Pages: 175-181
- DOI
  10.5312/wjo.v3.i11.175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390351, KAKENHI-PROJECT-23593054, KAKENHI-PROJECT-24592821, KAKENHI-PROJECT-24659833
[Journal Article] Polarized osteoclasts put marks of tartrate-resistant acid phosphatase on dentin slices. A simple method for identifying polarized osteoclasts2012
- Author(s)
  Nakayama T, et al
- Journal Title
  
  Bone
  
  Volume: 49 Pages: 1331-1339
- DOI
  10.1016/j.bone.2011.09.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390505, KAKENHI-PROJECT-21592378, KAKENHI-PROJECT-22390351, KAKENHI-PROJECT-22659339, KAKENHI-PROJECT-22791804, KAKENHI-PROJECT-23792134
[Journal Article] Polarized osteoclasts put marks of tartrate-resistant acid phosphatase on dentin slices-a simple method for identifying polarized osteoclasts2011
- Author(s)
  Nakayama T, Mizoguchi T, Uehara S, Yamashita T, Kawahara I, Kobayashi Y, Moriyama Y, Kurihara S, Sahara N, Ozawa H, Udagawa N, Takahashi N
- Journal Title
  
  Bone
  
  Volume: 49 Pages: 1331-1339
- URL
  http://dx.doi.org/10.1016/j.bone.2011.09.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390551
[Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.2009
- Author(s)
  Mizoguchi T, Muto A, Udagawa N, Arai A, Yamashita T, Hosoya A, Ninomiya T, Nakamura H, Yamamoto Y, Kinugawa S, Nakamura M, Nakamichi Y, Kobayashi Y, Nagasawa S, Oda K, Tanaka H, Tagaya M, Penninger JM, Ito M, Takahashi N
- Journal Title
  
  J Cell Biol 184
  
  Pages: 541-554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592163
[Journal Article] Docetaxel inhibits bone resorption through suppression of osteoclast formation and function in different manners.2009
- Author(s)
  Takahashi M, Mizoguchi T, Uehara S, Nakamichi Y, Yang S, Naramoto H, Yamashita T, Kobayashi Y, Yamaoka M, Furusawa K, Udagawa N, Uematsu T, Takahashi N
- Journal Title
  
  J Bone Miner Metab 27
  
  Pages: 24-35
- NAID
  10025336084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592163
[Journal Article] Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling2009
- Author(s)
  Koide M, Kinugawa S, Ninomiya T, Mizoguchi T, Yamashita T, Maeda K, Yasuda H, Kobayashi Y, Nakamura H, Takahashi N, Udagawa N
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: 24(8) Pages: 1469-1480
- DOI
  10.1359/jbmr.090302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592378
[Journal Article] Docetaxel inhibits bone resorption through suppression of osteoclast formation and function different manners.2009
- Author(s)
  Takahashi M, Mizoguchi T, Nakamichi Y, Yamashita T, Udagawa N, Takahashi N
- Journal Title
  
  J. Bone Miner. Metab. 27
  
  Pages: 24-35
- NAID
  10025336084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200019
[Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo2009
- Author(s)
  Mizoguchi T, Muto A, Udagawa N, Arai A, Yamashita T, Hosoya A, Ninomiya T, Nakamura H, Yamamoto Y, Kinugawa S, Nakamura M, Nakamichi Y, Kobayashi Y, Nagasawa S, Oda K, Tanaka H, Tagaya M, Penninger JM, Ito M, Takahashi N.
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 184(4) Pages: 541-54
- DOI
  10.1083/jcb.200806139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390505, KAKENHI-PROJECT-21592378
[Journal Article] Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling.2009
- Author(s)
  Koide M, Nynomiya T, Mizoguchi T, Yamashita T, Nakamura H, Takahashi N, Udagawa N
- Journal Title
  
  J Bone Miner Res. 24
  
  Pages: 1469-1480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200019
[Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.2009
- Author(s)
  Mizoguchi T, Udagawa N, Yamashita T, Hosoya A, Ninomiya T, Nakamichi Y, Takahashi N
- Journal Title
  
  J Cell Biol. 184
  
  Pages: 541-554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200019
[Journal Article] MKK6-p38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts.2008
- Author(s)
  Yamashita T, Kobayashi Y, Mizoguchi T, Yamaki M, Miura T, Tanaka S, Udagawa N, Takahashi N
- Journal Title
  
  Biochem Biophys Res Commun 365
  
  Pages: 252-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592163
[Journal Article] MKK6-p38MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts2008
- Author(s)
  Teruhito Yamashita, et. al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 365
  
  Pages: 252-257
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390557
[Journal Article] MKK6-p38MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts2008
- Author(s)
  Teruhito Yamashita, et. al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 365
  
  Pages: 252-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390557
[Journal Article] MKK6-p38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts.2008
- Author(s)
  Yamashita T, et. al.
- Journal Title
  
  Biochem Biophys Res Commun 365
  
  Pages: 252-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592163
[Journal Article] MKK6-p38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts.2008
- Author(s)
  Yamashita T, et. al.
- Journal Title
  
  Biochem Biophys Res Commun 365
  
  Pages: 252-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659619
[Journal Article] MKK6-p38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts.2008
- Author(s)
  Teruhito Yamashita
- Journal Title
  
  Biochem Biophys Res Commun 365
  
  Pages: 252-257
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390557
[Journal Article] MKK6-P38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts.2008
- Author(s)
  Yamashita T, et al.
- Journal Title
  
  Biochem Biophys Res Commun 365
  
  Pages: 252-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659291
[Journal Article] Signal transduction of lipopolysaccharide- induced osteoclast differentiation.2007
- Author(s)
  Udagawa N, Sato N, Yang S, Nakamura M, Yamashita T, Nakamura H, Noguchi T
- Journal Title
  
  Periodontology 2000 43
  
  Pages: 56-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592163
[Journal Article] NF-{kappa}B p50 and p52 Regulate Receptor Activator of NF-{kappa}B Ligand(RANKL)and Tumor Necrosis Factor-induced Osteoclast Precurs or Differentiation by Activating c-Fos and NFATcl.2007
- Author(s)
  Yamashita T, et. al.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 18245-18253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592163
[Presentation] Macrophages promote bone regeneration through the activation of LepR (+) cells2021
- Author(s)
  何治鋒，溝口　利英，平賀徹，村上康平，中道裕子，山下照仁，小出雅則，宇田川信之，小林泰浩
- Organizer
  第91回松本歯科大学学会
- Data Source
  KAKENHI-PROJECT-19K22729
[Presentation] マクロファージはLepR陽性細胞を活性化し骨再生を促進する2021
- Author(s)
  何治鋒，溝口　利英，平賀徹，村上康平，中道裕子，山下照仁，小出雅則，宇田川信之，小林泰浩
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K22729
[Presentation] マクロファージはLepR(+)細胞を活性化し、骨再生を促進する2021
- Author(s)
  何　治鋒、平賀　徹、石　莉楠、李　若萱、中道裕子、山下照仁、小出正則、宇田川信之、小林泰浩
- Organizer
  第91回松本歯科大学学会
- Data Source
  KAKENHI-PROJECT-21K09863
[Presentation] マクロファージはLepR陽性細胞を活性化し骨再生を促進する2021
- Author(s)
  何治鋒，溝口　利英，平賀徹，村上康平，中道裕子，山下照仁，小出雅則，宇田川信之，小林泰浩
- Organizer
  日本骨代謝学会学術集会（第39回）
- Data Source
  KAKENHI-PROJECT-21H03125
[Presentation] マクロファージはLepR陽性細胞を活性化し骨再生を促進する2021
- Author(s)
  何治鋒，溝口　利英，平賀徹，村上康平，中道裕子，山下照仁，小出雅則，宇田川信之，小林泰浩
- Organizer
  日本骨代謝学会学術集会（第39回）
- Data Source
  KAKENHI-PROJECT-20K21689
[Presentation] マクロファージはLepR陽性細胞を活性化し骨再生を促進する2021
- Author(s)
  何　治鋒、溝口利英、平賀　徹、村上康平、中道裕子、山下照仁、小出雅則、宇田川信之、小林泰浩
- Organizer
  第39回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-21K09863
[Presentation] BMP 誘導性の異所性骨における骨形成抑制因子スクレロスチン陽性細胞の経時的観察2020
- Author(s)
  松下雅衣，小出雅則，芳澤享子，堀部寛治，小林泰浩，山下照仁，中道裕子，上原俊介，宇田川信之
- Organizer
  歯科基礎学会学術大会（第62回）
- Data Source
  KAKENHI-PROJECT-20K21689
[Presentation] BMP 誘導性の異所性骨における骨形成抑制因子スクレロスチン陽性細胞の経時的観察2020
- Author(s)
  松下雅衣，小出雅則，芳澤享子，堀部寛治，小林泰浩，山下照仁，中道裕子，上原俊介，宇田川信之
- Organizer
  第62回歯科基礎学会学術大会
- Data Source
  KAKENHI-PROJECT-19K22729
[Presentation] プロテインキナーゼN3 (Pkn3) 阻害剤は、卵巣切除に伴う骨量減少を骨吸収抑制により軽減する2020
- Author(s)
  上原俊介，山下照仁，村上康平，小出雅則，宇田川信之，小林泰浩
- Organizer
  日本骨代謝学会学術集会（第38回）
- Data Source
  KAKENHI-PROJECT-20K21689
[Presentation] プロテインキナーゼN3 (Pkn3) 阻害剤は、卵巣切除に伴う骨量減少を骨吸収抑制により軽減する2020
- Author(s)
  上原俊介，山下照仁，村上康平，小出雅則，宇田川信之，小林泰浩
- Organizer
  第38回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K22729
[Presentation] BMP 誘導性の異所性骨における骨形成抑制因子スクレロスチン陽性細胞の経時的観察2020
- Author(s)
  松下雅衣，小出雅則，芳澤享子，堀部寛治，小林泰浩，山下照仁，中道裕子，上原俊介，宇田川信之
- Organizer
  歯科基礎学会学術大会（第62回）
- Data Source
  KAKENHI-PROJECT-18K09531
[Presentation] プロテインキナーゼN3 (Pkn3) 阻害剤は、卵巣切除に伴う骨量減少を骨吸収抑制により軽減する2020
- Author(s)
  上原俊介，山下照仁，村上康平，小出雅則，宇田川信之，小林泰浩
- Organizer
  日本骨代謝学会学術集会（第38回）
- Data Source
  KAKENHI-PROJECT-19K10395
[Presentation] Wnt/β-cateninシグナルの制御系をモニターするSost-Greenレポーターマウスの作出2019
- Author(s)
  山下照仁，小出雅則，堀部寛治，上原俊介，宇田川信之，高橋直之，中村浩彰，小林泰浩
- Organizer
  第88回松本歯科大学学会総会
- Data Source
  KAKENHI-PROJECT-18K09531
[Presentation] Sost遺伝子レポーターマウスの骨における解析2019
- Author(s)
  山下照仁
- Organizer
  大阪大学蛋白質研究所セミナー「Wnt研究会2018-2019」
- Data Source
  KAKENHI-PROJECT-18K09531
[Presentation] Siglec-15中和抗体による骨吸収抑制作用と骨芽細胞分化促進作用2019
- Author(s)
  宇田川信之，小出雅則，上原俊介，荒井敦，溝口利英，山下照仁，中村美どり，小林泰浩，高橋直之，熊倉誠一郎，福田千恵，津田英資
- Organizer
  日本再生医療学会総会（第18回）
- Data Source
  KAKENHI-PROJECT-19K10395
[Presentation] The restorative effects of W9 peptide on alveolar bone loss in OPG-deficient mice2019
- Author(s)
  Masanori Koide, Yuki Ozaki, Yuriko Furuya, Hisataka Yasuda, Teruhito Yamashita, Yasuhiro Kobayashi, Naoyuki
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22729
[Presentation] 破骨細胞はLIF発現を亢進して、スクレロスチン発現を抑制する2019
- Author(s)
  小出雅則, 小林泰浩, 山下照仁，上原俊介，村上康平，高橋直之，宇田川信之
- Organizer
  第4回日本骨免疫学会ウインターセミナー
- Data Source
  KAKENHI-PROJECT-19K22729
[Presentation] Osteoclasts promote trabecular bone formation through the suppression of sclerostin expression2019
- Author(s)
  Masanori Koide, Yasuhiro Kobayashi, Teruhito Yamashita, Kohei Murakami, Shunsuke Uehara, Hisataka Yasuda, Naoyuki Takahashi, Nobuyuki Udagawa
- Organizer
  The American Society for Bone and Mineral Research (ASBMR) 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22729
[Presentation] Importance of osteoclasts in osteogenic signals.2019
- Author(s)
  Nobuyuki Udagawa, Masanori Koide, Teruhito Yamashita, Midori Nakamura, Shunsuke Uehara, Yasuhiro Kobayashi, Naoyuki Takahashi
- Organizer
  日本分子生物学会年会（第42回）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10395
[Presentation] Siglec‐15中和抗体による骨吸収抑制作用と骨芽細胞分化促進作用2019
- Author(s)
  宇田川信之,小出雅則,上原俊介,荒井敦,溝口利英,山下照仁,中村美どり,小林泰浩,高橋直之,熊倉誠一郎,福田千恵,津田英資
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-19K22729
[Presentation] Pkn3阻害剤による骨吸収抑制2019
- Author(s)
  上原俊介，村上康平，山下照仁，小出雅則，高橋直之，宇田川信之，小林泰浩
- Organizer
  第4回日本骨免疫学会ウインターセミナー
- Data Source
  KAKENHI-PROJECT-19K22729
[Presentation] Osteoclasts promote trabecular bone formation through the suppression of sclerostin expression.2019
- Author(s)
  Masanori Koide, Yasuhiro Kobayashi, Teruhito Yamashita, Kohei Murakami, Shunsuke Uehara, Hisataka Yasuda, Naoyuki Takahashi, Nobuyuki Udagawa
- Organizer
  The American Society for Bone and Mineral Research (ASBMR) 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10395
[Presentation] Osteoclasts promote trabecular bone formation through the suppression of sclerostin expression2019
- Author(s)
  Masanori Koide, Yasuhiro Kobayashi, Teruhito Yamashita, Kohei Murakami, Shunsuke Uehara, Hisataka Yasuda, Naoyuki Takahashi, Nobuyuki Udagawa
- Organizer
  The American Society for Bone and Mineral Research (ASBMR) 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09531
[Presentation] WntアンタゴニストSfrp5は破骨細胞の分化を抑制し、骨芽細胞の分化を促進する2019
- Author(s)
  村上康平, 宇田川信之, 上原俊介, 小出雅則, 山下照仁, 小林泰浩
- Organizer
  第37回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-19K22729
[Presentation] 有袋類や単孔類のカルシトニンは強力な生物活性を持つ2017
- Author(s)
  山下照仁，宇田川信之，山内広世，鈴木信雄，上原俊介，小林泰浩，高橋直之
- Organizer
  日本骨代謝学会学術集会 (第35回)
- Place of Presentation
  ホテル日航福岡(福岡県)
- Year and Date
  2017-07-27
- Data Source
  KAKENHI-PROJECT-15K15688
[Presentation] Annexin A5 prevents force-mediated bone ridge overgrowth at the enthesis2017
- Author(s)
  Shimada A., Arai Y., Komatsu K., Wada S., Ideno H., Nakashima K., Yamashita T., Ezura Y., Amizuka N., Poumlschl E., Brachvogel B., Nakamura Y., Nifuji A.
- Organizer
  Spring Harbor Lab meeting, Annexins: 9th International Conference on the Annexins
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11655
[Presentation] 腱・靭帯付着部（enthesis）においてAnnexin A5は線維軟骨の分化を負に制御する2017
- Author(s)
  島田明美、新井嘉則、小松浩一郎、和田悟史、出野尚、中島和久、山下照仁、江面陽一、網塚憲生、中村芳樹、二藤彰
- Organizer
  第35回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11655
[Presentation] Annexin a5による腱・靭帯付着部（enthesis）における骨増大の抑制2016
- Author(s)
  島田明美、新井嘉則、和田悟史、出野尚、中島和久、小松浩一郎、山下照仁、江面陽一、中村芳樹、二藤彰
- Organizer
  第2回日本アネキシン研究会年会
- Place of Presentation
  札幌医科大学（北海道、札幌市）
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-26462825
[Presentation] Annexin a5による腱・靭帯付着部（enthesis）における線維軟骨層の石灰化の制御2016
- Author(s)
  島田明美、新井嘉則、和田悟史、出野尚、中島和久、小松浩一郎、山下照仁、江面陽一、網塚憲生、中村芳樹、二藤彰
- Organizer
  第34回日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府、大阪市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26462825
[Presentation] アネキシンA5欠損マウスは歯の咬耗と腱付着部における顎骨の肥大を呈する2015
- Author(s)
  島田明美, 小松浩一郎, 新井嘉則, 大貫芳樹, 中島和久, 山下照仁, 奥村敏, 二藤彰
- Organizer
  第57回歯科基礎医学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県、新潟市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26462825
[Presentation] A RANKL-binding peptide W9 inhibits human osteoclast differentiation and stimulates human osteoblast differentiation2015
- Author(s)
  Nakamura M, Nakamichi Y, Yamashita T, Furuya Y, Yasuda H, Udagawa N
- Organizer
  米国骨代謝学会（ASBMR）
- Place of Presentation
  ワシントンステートコンベンションセンター（米国ワシントン州）
- Year and Date
  2015-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15688
[Presentation] nnexin a5による腱・靭帯付着部（enthesis）における骨形成の調節2015
- Author(s)
  島田明美、新井嘉則、和田悟史、出野尚、上運天太一、中島和久、小松浩一郎、山下照仁、江面陽一、網塚憲生、中村芳樹、二藤彰
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  京王プラザホテル（東京都、新宿区）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-26462825
[Presentation] Rho-Pkn3 Pathway Regulates the Bone-resorbing Activity of Osteoclasts under Wnt5a-Ror22015
- Author(s)
  Uehara S, Mukai H, Yamashita T, Nakamura T, Kato S, Kikuchi A, Nishita M, Minami Y, Udagawa N, Takahashi N, Kobayashi Y
- Organizer
  米国骨代謝学会（ASBMR）
- Place of Presentation
  ワシントンステートコンベンションセンター（米国ワシントン州）
- Year and Date
  2015-10-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15688
[Presentation] Annexin A5 inhibits bony outgrowth at tendon/ligament insertion sites.2015
- Author(s)
  Shimada A, Arai Y, Wada S, Ideno H, Kamiunten T, Nakashima K, Komatsu K, Yamashita T, Ezura Y, Amizuka N, Pöschl E, Brachvogel B, Nakamura Y, Nifuji A
- Organizer
  ASBMR 2015 annual meeting
- Place of Presentation
  Washington State Convention Center （USA, WA, Seattle）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-26462825
[Presentation] アルクチゲニンの破骨細胞分化抑制メカニズム2014
- Author(s)
  山下照仁，小林泰浩，上原俊介，宇田川信之，李峰，門田重利，江角浩安，高橋直之
- Organizer
  第56回歯科基礎医学会学術大会・総会
- Place of Presentation
  福岡国際会議場（福岡市）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-24592821
[Presentation] 抗炎症作用を持つアルクチゲニンの破骨細胞抑制メカニズム2014
- Author(s)
  山下照仁，小林泰浩，上原俊介，宇田川信之，李峰，門田重利，江角浩安，高橋直之
- Organizer
  第1回日本骨免疫会議
- Place of Presentation
  万国津梁館（名護市）
- Year and Date
  2014-07-04
- Data Source
  KAKENHI-PROJECT-24592821
[Presentation] Arctigenin Inhibits Osteoclastogenesis by Suppressing Both Calcineurin-Dependent and Osteoblastic Cell-Dependent NFATc1 Pathways2014
- Author(s)
  Yamashita T，Uehara S，Udagawa N，Li F，Kadota S，Esumi H，Kobayashi Y，Takahashi N
- Organizer
  ASBMR 2014 Annual Meeting
- Place of Presentation
  George R. Brown Convention Center （Houston, USA）
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-24592821
[Presentation] Wnt5a enhances Wnt/beta-catenin signaling through the up-regulation of Lrp5/6 during osteogenesis2013
- Author(s)
  Okamoto M, UdagawaN, Yamashita T, Uehara S, Kato H, Saito N, Minami Y, Takahashi N, Kobayashi Y
- Organizer
  2013　米国骨代謝学会
- Place of Presentation
  Baltimore　Convention Center, USA
- Data Source
  KAKENHI-PROJECT-25293423
[Presentation] アルクチゲニンはNFATc1の核移行を促進するが転写活性を抑制する2011
- Author(s)
  山下照仁
- Organizer
  日本骨代謝学会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2011-07-30
- Data Source
  KAKENHI-PROJECT-21592378
[Presentation] 漢方牛蒡子由来のアルクチゲニンは破骨細胞の分化と機能を抑制する2010
- Author(s)
  山下照仁
- Organizer
  日本骨代謝学会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2010-07-21
- Data Source
  KAKENHI-PROJECT-21592378
[Presentation] 漢方牛蒡子由来のアルクチゲニンは破骨細胞の機能と分化を抑制する2010
- Author(s)
  山下照仁、上原俊介、小林泰浩、宇田川信之、高橋直之
- Organizer
  第28回日本骨代謝学会学術大会
- Place of Presentation
  東京
- Year and Date
  2010-07-21
- Data Source
  KAKENHI-PROJECT-21390551
[Presentation] In vivoにおいて細胞周期の停止した破骨細胞前駆細胞(pOCP)は5-FU非感受性である2007
- Author(s)
  溝口利英、武藤昭紀、細矢明宏、中道裕子、山下照仁、小林泰浩、宇田川信之、伊藤充雄、高橋直之
- Organizer
  日本骨代謝学会
- Place of Presentation
  大阪市大阪国際会議場
- Year and Date
  2007-07-21
- Data Source
  KAKENHI-PROJECT-19592163
[Presentation] 破骨細胞のMAPキナーゼp38経路を制御する因子Alixの同定2007
- Author(s)
  山下照仁, 他
- Organizer
  日本骨代謝学会
- Place of Presentation
  大阪市大阪国際会議場
- Year and Date
  2007-07-21
- Data Source
  KAKENHI-PROJECT-19592163
[Presentation] 破骨細胞のMAPキナーゼp38経路を制御する因子Alixの同定2007
- Author(s)
  山下照仁、溝口利英、小林泰浩、二宮禎、宇田川信之、高橋直之
- Organizer
  日本骨代謝学会
- Place of Presentation
  大阪市大阪国際会議場
- Year and Date
  2007-07-21
- Data Source
  KAKENHI-PROJECT-19592163
[Presentation] Arctigenin Inhibits Transcriptional Activity of NFATc1 by Its Nuclear Translocation- Independent Mechanism
- Author(s)
  Yamashita T，Uehara S，Udagawa N，Kobayashi Y，Takahashi N
- Organizer
  国際骨代謝学会および日本骨代謝学会
- Place of Presentation
  ポートピアホテル（神戸市）
- Data Source
  KAKENHI-PROJECT-24592821
[Presentation] 破骨細胞の分化に必須な因子NFATc1の転写活性を抑制するアルクチゲニンの作用メカニズム
- Author(s)
  山下照仁，李峰，上原俊介，小林泰浩，宇田川信之，門田重利，高橋直之
- Organizer
  松本歯科大学学会
- Place of Presentation
  松本歯科大学（塩尻市）
- Data Source
  KAKENHI-PROJECT-24592821

1. UDAGAWA Nobuyuki (70245801)

# of Collaborated Projects: 12 results

# of Collaborated Products: 31 results
2. TAKAHASHI Naoyuki (90119222)

# of Collaborated Projects: 11 results

# of Collaborated Products: 39 results
3. KOIDE Masanori (10367617)

# of Collaborated Projects: 9 results

# of Collaborated Products: 25 results
4. NAKAMICHI Yuko (20350829)

# of Collaborated Projects: 9 results

# of Collaborated Products: 8 results
5. KOBAYASHI Yasuhiro (20264252)

# of Collaborated Projects: 9 results

# of Collaborated Products: 33 results
6. NIFUJI Akira (00240747)

# of Collaborated Projects: 8 results

# of Collaborated Products: 7 results
7. NAKAMURA Midori (90278177)

# of Collaborated Projects: 7 results

# of Collaborated Products: 9 results
8. NINOMIYA Tadashi (00360222)

# of Collaborated Projects: 7 results

# of Collaborated Products: 5 results
9. NODA Masaki (50231725)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
10. MIZOGUCHI Toshihide (90329475)

# of Collaborated Projects: 6 results

# of Collaborated Products: 11 results
11. 上原俊介 (90434480)

# of Collaborated Projects: 6 results

# of Collaborated Products: 21 results
12. HIRAGA Tohru (70322170)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
13. 中村浩志 (00278178)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
14. HIRAOKA Yukihiro (20097512)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. NAKAMURA Hiroaki (50227930)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
16. Shimada Akemi (00339813)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
17. 宮沢裕夫 (90147637)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. 大須賀直人 (80247535)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. HOSOYA Akihiro (70350824)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. OZAWA Hidehiro (60018413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. TSUJI Kunikazu (20323694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TAKAHASHI Masahiro (90340059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. UEMATSU Takashi (40203476)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 和田悟史 (20581119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
25. 田村正人 (30236757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 川口奈奈子 (10200700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 奥村茂樹 (80350825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 小松浩一郎 (60153665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
29. 堀部寛治 (70733509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
30. 村上康平 (60791837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
31. 尾崎友輝 (10802902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
32. 岩本莉奈 (20907216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 北川教弘 (30294284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 岡千緒 (30263445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 別所康全 (70261253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. KADOTA Shigetoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
37. KIKUCHI Takanobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. ARAI Yoshinori

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
39. YAMAUCHI Hirose

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
40. OKABE Koji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. THIRUKONDA Gnanasagar

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
42. DENHARDT Dav

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. NAKAMURA Maki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
44. NISHITA MICHIRU

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. MAEDA Kazuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. HARA Kazuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. OKAMOTO Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. KOBAYASHI Shinsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 荒敏昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
50. 浅田梨絵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 金本聡自

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 今泉和則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 金子雅幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 飯村忠浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. 向井秀幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 南康博

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
57. 畠山金太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 山下篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. 鶴田敏博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
60. 斎藤直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
61. 加藤博之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
62. 安孫子宜光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

yamashita teruhito 山下 照仁

YAMASHITA Teruhito 山下 照仁

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スクレロスチンによる破骨細胞の骨吸収制御機構の解明と新規骨吸収阻害薬の開発Principal Investigator

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Does aging of osteocytes adversely affect bone metabolism?Principal Investigator

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Investigation of factors determining terminal differentiation into osteocytesPrincipal Investigator

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yamashita teruhito 山下照仁

YAMASHITA Teruhito 山下照仁