MUKOUYAMA JUNKO 向山順子

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MUKOHYAMA JUNKO 向山順子

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Researcher Number	70734987
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 国際医療福祉大学, 国際医療福祉大学三田病院, 講師 2017 – 2023: 神戸大学, 医学研究科, 医学研究員
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 大腸癌 / 発癌機構 / 細胞系譜 / 内分泌細胞 / 最適化治療 / QKI5 / シークエンス解析 / 癌幹細胞 / QKI / RNA結合蛋白 / miR-221 / マイクロRNA … More Except Principal Investigator … More フリーラジカル / 超音波 / 肝癌 / 肝動注療法 / 免疫不全ブタ / 肝癌大動物モデル / 消化器癌 / 腫瘍微小環境 / 抗体薬剤複合体 / B細胞 / 抗体取得 / 三次リンパ構造 / 胃癌 / 骨髄由来抑制性細胞 / miRNA / 肺転移 / 臓器指向性 / 肝転移 / 原発巣切除 / microRNA / micro RNA / 転移ニッチ / 涙 / 早期再発検出 / 術後サーベイランス / エクソソーム / 大腸癌 Less

scTranscriptome解析による難治性右側大腸癌の発癌機構の解明Principal Investigator
- Principal Investigator
  
  向山順子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  International University of Health and Welfare
ヒト肝癌移植Il2rg-KOブタを用いた酸化チタンナノ粒子超音波併用肝動注療法
- Principal Investigator
  
  板野理
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  International University of Health and Welfare
Development and application of an early detection method for postoperative recurrence of colorectal cancer using tears
- Principal Investigator
  
  Matsuda Takeru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kobe University
Development of novel therapies for endocrine cell originated colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Mukohyama Jyunko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kobe University
Elucidation of the mechanism of maturation of tertiary lymph structure in gastric cancer tumor immune microenvironment and identification of the therapeutic antibodies
- Principal Investigator
  
  Kakeji Yoshihiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kobe University
The regulation of colon cancer stem cell by QKI5Principal Investigator
- Principal Investigator
  
  MUKOHYAMA JUNKO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kobe University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] CDX2 Is a Prognostic Biomarker for Unresectable Metastatic Colorectal Cancer2023
- Author(s)
  MUKOHYAMA JUNKO、AGAWA KYOSUKE、YAMASHITA KIMIHIRO、MATSUDA TAKERU、SHINODA MASAHIRO、ITANO OSAMU、KAKEJI YOSHIHIRO
- Journal Title
  
  Anticancer Research
  
  Volume: 43 Issue: 8 Pages: 3763-3767
- DOI
  10.21873/anticanres.16561
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07062, KAKENHI-PROJECT-21K08778, KAKENHI-PROJECT-20K17687
[Journal Article] Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells.2022
- Author(s)
  Shigeo Hisamori, *, Junko Mukohyama*, 6yt5Koul Sanjay, Takanori Hayashi, Michael E. Rothenberg, Masao Maeda, Taichi Isobe, Luis E. Valencia Salazar, Xin Qian, Darius M. Johnston, Dalong Qian, Kaiqin Lao, Naoya Asai,, Yoshihiro Kakeji, Vincenzo A. Gennarino, Debashis Sahoo Piero Dalerba, Yohei Shimono
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: in print
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17687
[Journal Article] Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells2022
- Author(s)
  Hisamori Shigeo、Mukohyama Junko、Koul Sanjay、Hayashi Takanori、Rothenberg Michael Evan、Maeda Masao、Isobe Taichi、Valencia Salazar Luis Enrique、Qian Xin、Johnston Darius Michael、Qian Dalong、Lao Kaiqin、Asai Naoya、Kakeji Yoshihiro、Gennarino Vincenzo Alessandro、Sahoo Debashis、Dalerba Piero、Shimono Yohei
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: Online ahead of print Issue: 6 Pages: 407-422
- DOI
  10.1007/s00535-022-01865-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09076, KAKENHI-PROJECT-21K07152, KAKENHI-PROJECT-22K07010, KAKENHI-PROJECT-20K17687, KAKENHI-PROJECT-23K21387
[Journal Article] Structural basis of cytokine-mediated activation of ALK family receptors2021
- Author(s)
  De Munck Steven、Provost Mathias、Kurikawa Michiko、Omori Ikuko、Mukohyama Junko、Felix Jan、Bloch Yehudi、Abdel-Wahab Omar、Bazan J. Fernando、Yoshimi Akihide、Savvides Savvas N.
- Journal Title
  
  Nature
  
  Volume: 600 Issue: 7887 Pages: 143-147
- DOI
  10.1038/s41586-021-03959-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04828, KAKENHI-PROJECT-20K17687
[Journal Article] Simple Cancer Stem Cell Markers Predict Neoadjuvant Chemotherapy Resistance of Esophageal Squamous Cell Carcinoma2021
- Author(s)
  AGAWA KYOSUKE、YAMASHITA KIMIHIRO、NAKAGAWA AKIO、YAMADA KOUTA、WATANABE AKIHIRO、MUKOHYAMA JUNKO、SAITO MASAFUMI、FUJITA MITSUGU、TAKIGUCHI GOSUKE、URAKAWA NAOKI、HASEGAWA HIROSHI、KANAJI SHINGO、MATSUDA TAKERU、OSHIKIRI TARO、NAKAMURA TETSU、SUZUKI SATOSHI、KAKEJI YOSHIHIRO
- Journal Title
  
  Anticancer Research
  
  Volume: 41 Issue: 8 Pages: 4117-4126
- DOI
  10.21873/anticanres.15214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08135, KAKENHI-PROJECT-19K09147, KAKENHI-PROJECT-20K17651, KAKENHI-PROJECT-20K09008, KAKENHI-PROJECT-20K09378, KAKENHI-PROJECT-21K09167, KAKENHI-PROJECT-20K16331, KAKENHI-PROJECT-20K17686, KAKENHI-PROJECT-20K17687
[Journal Article] miR-221 Targets QKI to Enhance the Tumorigenic Capacity of Human Colorectal Cancer Stem Cells.2019
- Author(s)
  Mukohyama J, Isobe T, Hu Q, Hayashi T, Watanabe T, Maeda M, Yanagi H, Qian X, Yamashita K, Minami H, Mimori K, Sahoo D, Kakeji Y, Suzuki A, Dalerba P, Shimono Y.
- Journal Title
  
  Cancer Research
  
  Volume: 79 Issue: 20 Pages: 5151-5158
- DOI
  10.1158/0008-5472.can-18-3544
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07231, KAKENHI-PROJECT-19K17831, KAKENHI-PROJECT-16H05415, KAKENHI-PROJECT-17K16172, KAKENHI-PROJECT-17K16555
[Journal Article] Recent advances of neoadjuvant chemoradiotherapy in rectal cancer: Future treatment perspectives2018
- Author(s)
  Yamashita Kimihiro、Matsuda Takeru、Hasegawa Hiroshi、Mukohyama Junko、Arimoto Akira、Tanaka Tomoko、Yamamoto Masashi、Matsuda Yoshiko、Kanaji Shingo、Nakamura Tetsu、Sumi Yasuo、Suzuki Satoshi、Kakeji Yoshihiro
- Journal Title
  
  Annals of Gastroenterological Surgery
  
  Volume: 3 Issue: 1 Pages: 24-33
- DOI
  10.1002/ags3.12213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16555, KAKENHI-PROJECT-16H05415
[Journal Article] Discordance of MCM7 mRNA and Its Intronic MicroRNA Levels under Hypoxia2017
- Author(s)
  Hiroki Kondo, Yohei Shimono, Junko Mukohyama, Yasuteru Tanaka, Naoki Shibuya, Hironobu Minami, Yoshihiro Kakeji, Akira Suzuki
- Journal Title
  
  Anticancer Research
  
  Volume: 37 Pages: 3885-3890
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16555
[Journal Article] Roles of microRNAs and RNA-binding proteins in the regulation of colorectal cancer stem cells.2017
- Author(s)
  Mukohyama J, Shimono Y, Minami H, Kakeji Y, Suzuki A.
- Journal Title
  
  CANCER
  
  Volume: 9(10) Issue: 10 Pages: 143-143
- DOI
  10.3390/cancers9100143
- NAID
  120006373809
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-16H05415, KAKENHI-PROJECT-17K16555
[Journal Article] MicroRNA Regulation of Cancer Stem Cells at the Primary and Metastatic Sites2017
- Author(s)
  下野洋平, 渋谷尚樹, 向山順子, 西村建徳, 後藤典子, 南博信, 掛地吉弘, 鈴木聡
- Journal Title
  
  Cytometry Research
  
  Volume: 27 Issue: 1 Pages: 33-39
- DOI
  10.18947/cytometryresearch.27.1_33
- NAID
  130006832441
- ISSN
  0916-6920, 2424-0664
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16555
[Presentation] 三刀流ママ外科医、Surgeon-scientistとして「外科的治療だけでは治癒が難しい癌」を研究する2024
- Author(s)
  向山順子、篠田昌宏、掛地吉弘、板野理
- Organizer
  日本外科学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K17687
[Presentation] 大腸癌手術前後における腸内細菌と代謝物の変化についての検討2023
- Author(s)
  向山　知佑
- Organizer
  第34回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-21K08778
[Presentation] miR-221 targets QKI5 and enhances functional behaviors of cancer stem cells in human colon cancers.2021
- Author(s)
  Junko Mukohyama, Osamu Itano, Yoshihiro Kakej, Yohei Shimono.
- Organizer
  International Colorectal Research Summit (ICRS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17687
[Presentation] DX2低発現大腸癌に対する最適化治療の確立に向けた研究2021
- Author(s)
  向山順子, Piero Dalerba
- Organizer
  第121回日本外科学会定期学術集会, 外科学再興シンポジウム13
- Invited
- Data Source
  KAKENHI-PROJECT-20K17687
[Presentation] CDX2 as a prognostic and predictive biomarker in colon cancer.2020
- Author(s)
  Junko Mukohyama, Piero Dalerba
- Organizer
  第79回日本癌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K17687
[Presentation] miR-221 enhances functional behaviors of cancer stem cells in human colorectal cancers2019
- Author(s)
  Junko Mukohyama, Yohei Shimono, Piero Dalerba, Taichi Isobe, Qingjiang Hu, Debashis Sahoo, Hironobu Minami, Koshi Mimori, Yoshihiro Kakeji, Akira Suzuki
- Organizer
  11th AACR-JCA joint conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16555
[Presentation] miR-221 enhances functional behaviors of cancer stem cells in human colorectal cancers.2019
- Author(s)
  unko Mukohyama, Yohei Shimono, Taichi Isobe, Qingjiang Hu, Debashis Sahoo, Hironobu Minami, Koshi Mimori, Piero Dalerba, Yoshihiro Kakeji, Akira Suzuki.
- Organizer
  11th AACR-JCA joint conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16555
[Presentation] Epigenetic regulation of colorectal cancer stem cells by the miR-221/QKI5 axis2018
- Author(s)
  Junko Mukohyama, Yohei Shimono, Piero Dalerba, Taichi Isobe, Qingjiang Hu, Debashis Sahoo, Naoki Shibuya, Hironobu Minami, Koshi Mimori, Yoshihiro Kakeji, Akira Suzuki.
- Organizer
  AACR Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16555
[Presentation] Epigenetic regulation of colorectal cancer stem cells by the miR-221/QKI5 axis2018
- Author(s)
  Junko Mukohyama, Yohei Shimono, Piero Dalerba, Taichi Isobe, Qingjiang Hu, Debashis Sahoo, Naoki Shibuya, Hironobu Minami, Koshi Mimori, Yoshihiro Kakeji, Akira Suzuki
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16555
[Presentation] miR-221-QKI5 axis regulates tumorigenicity of human colorectal cancer stem cells2017
- Author(s)
  Junko Mukohyama, Yohei Shimono, Taichi Isobe, Qingjiang Hu, Naoki Shibuya, Kimihiro Yamashita, Koshi Mimori, Hironobu Minami, Yoshihiro Kakeji, Akira Suzuki
- Organizer
  The 76th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-17K16555
[Presentation] MicroRNA-mediated upregulation of the WNT signaling activities in human breast cancer stem cells2017
- Author(s)
  Yohei Shimono, Taichi Isobe, Andrei Turtoi, Junko Mukohyama, Toru Mukohara, Akira Suzuki, Vincent Castronovo, Hironobu Minami
- Organizer
  ACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16555
[Presentation] Detection of EBV BamHI W region in surgical cancer specimen is a useful method to evaluate the risk of lymphomagenesis in patient-derived tumor xenografts2017
- Author(s)
  Junko Mukohyama, Dai Iwakiri, Yoh Zen, Toru Mukohara, Hironobu Minami, Yoshihiro Kakeji, Yohei Shimono
- Organizer
  ACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16555

1. Kakeji Yoshihiro (80284488)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 山下公大 (80535427)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 中野秀雄 (00237348)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 藤田貢 (40609997)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. Matsuda Takeru (30782734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 竹内俊文 (70179612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 谷野裕一 (50285392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 犬伏祥子 (60585959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 青井貴之 (00546997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 岡田誠治 (50282455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 高村史記 (90528564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 吉見昭秀 (80609016)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 板野理 (90265827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 淵本大一郎 (10343998)

# of Collaborated Projects: 1 results

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15. 赤羽正章 (30282528)

# of Collaborated Projects: 1 results

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16. 井上政則 (30338157)

# of Collaborated Projects: 1 results

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17. 大西彰 (30414890)

# of Collaborated Projects: 1 results

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18. 小無田美菜 (30441653)

# of Collaborated Projects: 1 results

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19. 李ヨキン (30599048)

# of Collaborated Projects: 1 results

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20. 久森重夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 下野洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 鈴木聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MUKOUYAMA JUNKO 向山 順子

MUKOHYAMA JUNKO 向山 順子

Research Projects

Research Products

Co-Researchers

scTranscriptome解析による難治性右側大腸癌の発癌機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト肝癌移植Il2rg-KOブタを用いた酸化チタンナノ粒子超音波併用肝動注療法

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development and application of an early detection method for postoperative recurrence of colorectal cancer using tears

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapies for endocrine cell originated colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of maturation of tertiary lymph structure in gastric cancer tumor immune microenvironment and identification of the therapeutic antibodies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The regulation of colon cancer stem cell by QKI5Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CDX2 Is a Prognostic Biomarker for Unresectable Metastatic Colorectal Cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells.2022

Author(s)

Journal Title

Data Source

[Journal Article] Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis of cytokine-mediated activation of ALK family receptors2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simple Cancer Stem Cell Markers Predict Neoadjuvant Chemotherapy Resistance of Esophageal Squamous Cell Carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miR-221 Targets QKI to Enhance the Tumorigenic Capacity of Human Colorectal Cancer Stem Cells.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recent advances of neoadjuvant chemoradiotherapy in rectal cancer: Future treatment perspectives2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discordance of MCM7 mRNA and Its Intronic MicroRNA Levels under Hypoxia2017

Author(s)

Journal Title

Data Source

[Journal Article] Roles of microRNAs and RNA-binding proteins in the regulation of colorectal cancer stem cells.2017

MUKOUYAMA JUNKO 向山順子

MUKOHYAMA JUNKO 向山順子