Yabuki Yasushi 矢吹悌

… Alternative Names

YABUKI Yasushi 矢吹悌

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Researcher Number	70756121
Other IDs
Affiliation (Current)	2025: 熊本大学, 発生医学研究所, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 熊本大学, 発生医学研究所, 准教授 2019 – 2022: 熊本大学, 発生医学研究所, 助教 2016 – 2018: 東北大学, 薬学研究科, 助教 2015: 東北大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Pharmacology in pharmacy / Basic Section 46010:Neuroscience-general-related / Medium-sized Section 45:Biology at organismal to population levels and anthropology, and related fields / Transformative Research Areas, Section (III) Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Transformative Research Areas, Section (III) / Applied pharmacology
Keywords	Principal Investigator グアニン四重鎖 / α-シヌクレイン / 液－液相分離 / うつ様行動 / T 型カルシウムチャネル / 薬理学 / 神経細胞 / オプトジェネティクス / RNA 相転移 / 細胞間伝播 … More / メタアグリゲート / アミロイド / 核酸高次構造 / 液-液相分離 / 神経変性 / ゾル－ゲル相転移 / α-Synuclein / RNA グアニン四重鎖 / うつ病 / ストレス応答 / うつ / 抑制性神経伝達 / ストレス耐性 / カルシウムチャネル / 神経活動 / ストレス / 脳・神経、脳神経疾患 / 生理学 / 神経薬理学 / 海馬神経新生 / 神経新生 / 神経科学 / 脳神経疾患 / 薬学 / FABP3 / パーキンソン病 … More Except Principal Investigator ストレス顆粒 / mRNA / 神経機能 / RNA高次構造 / 神経疾患 / 神経細胞 / RNA相分離 / グアニン四重鎖 / 女性活躍 / 国際共同研究 / アウトリーチ / 若手支援 / 研究推進 / 薬物治療学 / 脳・神経 / 脳神経疾患 / 薬理学 / シヌクレイノパチー / α－シヌクレイン / 神経薬理学 / FABP3 / アラキドン酸 / αシヌクレイン / FABPリガンド / 脂肪酸結合蛋白質 / パーキンソン病 Less

核内液－液相分離環境破綻による神経細胞死メカニズムの解明Principal Investigator
- Principal Investigator
  
  矢吹悌
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Kumamoto University
The establishment of switching on/off system of a non-canonical nucleic acid structure using optogeneticsPrincipal Investigator
- Principal Investigator
  
  矢吹悌
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 45:Biology at organismal to population levels and anthropology, and related fields
- Research Institution
  Kumamoto University
Supramolecular behavior and dynamic capture of meta-aggregates
- Principal Investigator
  
  村上一馬
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
[Amyloid and nucleic acid structure] The formation and propagation of meta-aggregates by RNA phase transitionPrincipal Investigator
- Principal Investigator
  
  矢吹悌
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kumamoto University
G4RNA相分離による神経機能制御メカニズムの解明
- Principal Investigator
  
  塩田倫史
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kumamoto University
Regulation of alpha-synuclein aggregation and propagation by RNA G-quadruplexes.Principal Investigator
- Principal Investigator
  
  Yabuki Yasushi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kumamoto University
Function of T-type calcium channel in stress-induced depressive-like behaviors in mice.Principal Investigator
- Principal Investigator
  
  Yabuki Yasushi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kumamoto University
Drug discovery and neurochemical researches about T-type calcium channel in neurogenesis.Principal Investigator
- Principal Investigator
  
  Yabuki Yasushi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Tohoku University
Drug development by investigation of a-synucelin aggregation mechanism through FABP
- Principal Investigator
  
  Fukunaga Kohji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University
Development of novel therapeutics for Parkinson disease by FABP3 ligandsPrincipal Investigator
- Principal Investigator
  
  YABUKI Yasushi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with the neurological disorder CANVAS2024
- Author(s)
  Kudo Kenta、Hori Karin、Asamitsu Sefan、Maeda Kohei、Aida Yukari、Hokimoto Mei、Matsuo Kazuya、Yabuki Yasushi、Shioda Norifumi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 4 Pages: 107138-107138
- DOI
  10.1016/j.jbc.2024.107138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06579, KAKENHI-PLANNED-23H03851
[Journal Article] RNA G-quadruplexes and calcium ions synergistically induce Tau phase transition<i>in vitro</i>2024
- Author(s)
  Yabuki Yasushi、Matsuo Kazuya、Komiya Ginji、Kudo Kenta、Hori Karin、Ikenoshita Susumu、Kawata Yasushi、Mizobata Tomohiro、Shioda Norifumi
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2024.03.01.582861
- Open Access
- Data Source
  KAKENHI-PROJECT-22KJ2516, KAKENHI-PROJECT-21K06579, KAKENHI-PLANNED-23H03851
[Journal Article] A cyclic pyrrole-imidazole polyamide reduces pathogenic RNA in CAG/CTG triplet repeat neurological disease models2023
- Author(s)
  Ikenoshita Susumu、Matsuo Kazuya、Yabuki Yasushi、Kawakubo Kosuke、Asamitsu Sefan、Hori Karin、Usuki Shingo、Hirose Yuki、Bando Toshikazu、Araki Kimi、Ueda Mitsuharu、Sugiyama Hiroshi、Shioda Norifumi
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 133 Issue: 22
- DOI
  10.1172/jci164792
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K13857, KAKENHI-PROJECT-22KJ2516, KAKENHI-PROJECT-22K05353, KAKENHI-PROJECT-21K06579, KAKENHI-PROJECT-22K19297, KAKENHI-PROJECT-22KJ1695, KAKENHI-PLANNED-23H03851, KAKENHI-PROJECT-21H04705, KAKENHI-PROJECT-23H00373, KAKENHI-PROJECT-23K24245
[Journal Article] RNA G-quadruplexes forming scaffolds for α-synuclein aggregation lead to progressive neurodegeneration2023
- Author(s)
  Matsuo Kazuya、Asamitsu Sefan、Maeda Kohei、Kawakubo Kosuke、Komiya Ginji、Kudo Kenta、Sakai Yusuke、Hori Karin、Ikenoshita Susumu、Usuki Shingo、Funahashi Shiori、Kawata Yasushi、Mizobata Tomohiro、Shioda Norifumi、Yabuki Yasushi
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2023.07.10.548322
- Open Access
- Data Source
  KAKENHI-PROJECT-22KJ2516, KAKENHI-PROJECT-21K06579, KAKENHI-PLANNED-23H03851
[Journal Article] α‐Synuclein decoy peptide protects mice against α‐synuclein‐induced memory loss2023
- Author(s)
  Guo Qingyun、Kawahata Ichiro、Jia Wenbin、Wang Haoyang、Cheng An、Yabuki Yasushi、Shioda Norifumi、Fukunaga Kohji
- Journal Title
  
  CNS Neuroscience & Therapeutics
  
  Volume: Online ahead of print. Issue: 6 Pages: 1-14
- DOI
  10.1111/cns.14120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06579, KAKENHI-PROJECT-22K06644, KAKENHI-PROJECT-22K19297, KAKENHI-PROJECT-20H03393, KAKENHI-PUBLICLY-21H00207
[Journal Article] The neuropathological mechanism on guanine-rich repeat expansion diseases2023
- Author(s)
  Yabuki Yasushi、Shioda Norifumi
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 158 Issue: 1 Pages: 30-33
- DOI
  10.1254/fpj.22078
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06579
[Journal Article] RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons2023
- Author(s)
  Asamitsu Sefan、Yabuki Yasushi、Matsuo Kazuya、Kawasaki Moe、Hirose Yuki、Kashiwazaki Gengo、Chandran Anandhakumar、Bando Toshikazu、Wang Dan Ohtan、Sugiyama Hiroshi、Shioda Norifumi
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 8
- DOI
  10.1126/sciadv.ade2035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06579, KAKENHI-PROJECT-22K05353, KAKENHI-PROJECT-22K19297, KAKENHI-PROJECT-20H03393, KAKENHI-PROJECT-20J00520, KAKENHI-PROJECT-22KJ1695, KAKENHI-PROJECT-22KJ2516, KAKENHI-PROJECT-20K15417, KAKENHI-PUBLICLY-21H00207, KAKENHI-PLANNED-20H05936, KAKENHI-PROJECT-21H04705, KAKENHI-PROJECT-21H02580
[Journal Article] Cav3.1 t-type calcium channel is critical for cell proliferation and survival in newly generated cells of the adult hippocampus.2021
- Author(s)
  Yabuki Y., Matsuo K., Yu M., Xu J., Sakimura K., Shioda N. & Fukunaga K.
- Journal Title
  
  Acta Physiol (Oxf).
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16369
[Journal Article] Father-to-offspring transmission of extremely long NOTCH2NLC repeat expansions with contractions: genetic and epigenetic profiling with long-read sequencing.2021
- Author(s)
  Fukuda H, Yamaguchi D, Nyquist K, Yabuki Y, Miyatake S, Uchiyama Y, Hamanaka K, Saida K, Koshimizu E, Tsuchida N, Fujita A, Mitsuhashi S, Ohbo K, Satake Y, Sone J, Doi H, Morihara K, Okamoto T, Takahashi Y, Wenger AM, Shioda N, Tanaka F, Matsumoto N, Mizuguchi T.
- Journal Title
  
  Clin Epigenetics.
  
  Volume: 13 Pages: 204-204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06579
[Journal Article] CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome.2021
- Author(s)
  Asamitsu S., Yabuki Y. (equal contribution), Ikenoshita S., Kawakubo K., Kawasaki M., Usuki S., Nakayama Y., Adachi K., Kugoh H., Ishii K., Matsuura T., Nanba E., Sugiyama H., Fukunaga K. & Shioda N.
- Journal Title
  
  Science Advances.
  
  Volume: 7(3)
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16369
[Journal Article] Role of T-type Calcium Channels in Regulating Neuronal Function2020
- Author(s)
  Yabuki Y.
- Journal Title
  
  Yakugaku Zasshi.
  
  Volume: 140(10) Pages: 1207-1212
- NAID
  130007920212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16369
[Journal Article] Identification and immunohistochemical characterization of G-quadruplexes in mouse brain.2020
- Author(s)
  Asamitsu S., Imai Y., Yabuki Y., Ikenoshita S., Takeuchi M., Kashiwagi H., Tanoue Y., Fukuda T. & Shioda N.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 531(1) Pages: 67-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16369
[Journal Article] Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain.2020
- Author(s)
  Yabuki Y., Matsuo K., Kawahata I., Fukui N., Mizobata T., Kawata Y., Owada Y., Shioda N. & Fukunaga K.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 21(6) Pages: 2230-2230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16369
[Journal Article] Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABAA Receptor.2020
- Author(s)
  Yabuki Y., Liu J., Kawahata I., Izumi H., Shinoda Y., Koga K., Ueno S., Shioda N. & Fukunaga K.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 21(15) Pages: 5525-5525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16369
[Journal Article] T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice2019
- Author(s)
  Wang Shuo、Yabuki Yasushi、Matsuo Kazuya、Xu Jing、Izumi Hisanao、Sakimura Kenji、Saito Takashi、Saido Takaomi C.、Fukunaga Kohji
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 1 Pages: e0211590-e0211590
- DOI
  10.1371/journal.pone.0211590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-16J02855, KAKENHI-PROJECT-18J20651
[Journal Article] Combined citicoline and docosahexaenoic acid treatment improves cognitive dysfunction following transient brain ischemia2019
- Author(s)
  Nakazaki Eri、Yabuki Yasushi、Izumi Hisanao、Shinoda Yasuharu、Watanabe Fumiko、Hishida Yukihiro、Kamimura Ayako、Fukunaga Kohji
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: pii: S1347-8613 Issue: 4 Pages: 30023-30024
- DOI
  10.1016/j.jphs.2019.02.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-16J02855
[Journal Article] T-type calcium channel enhancer SAK3 produces anti-depressant-like effects by promoting adult hippocampal neurogenesis in olfactory bulbectomized mice2018
- Author(s)
  Xu Jing、Yabuki Yasushi、Yu Mengze、Fukunaga Kohji
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 137 Issue: 4 Pages: 333-341
- DOI
  10.1016/j.jphs.2018.07.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-17K15456
[Journal Article] T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.2018
- Author(s)
  Wang S, Yabuki Y, Matsuo K, Xu J, Izumi H, Sakimura K, Saito T, Saido TC, Fukunaga K.
- Journal Title
  
  PLoS One
  
  Volume: １３ Issue: 12 Pages: e0206986-e0206986
- DOI
  10.1371/journal.pone.0206986
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15456
[Journal Article] SA4503, A Potent Sigma-1 Receptor Ligand, Ameliorates Synaptic Abnormalities and Cognitive Dysfunction in a Mouse Model of ATR-X Syndrome2018
- Author(s)
  Yamaguchi Kouya、Shioda Norifumi、Yabuki Yasushi、Zhang Chen、Han Feng、Fukunaga Kohji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 9 Pages: 2811-2811
- DOI
  10.3390/ijms19092811
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-16K08265
[Journal Article] Acute Treatment with T-Type Calcium Channel Enhancer SAK3 Reduces Cognitive Impairments Caused by Methimazole-Induced Hypothyroidism Via Activation of Cholinergic Signaling.2018
- Author(s)
  Husain N, Yabuki Y, Shinoda Y, Fukunaga K.
- Journal Title
  
  Pharmacology.
  
  Volume: 101 Issue: 5-6 Pages: 309-321
- DOI
  10.1159/000488083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15456, KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-16K14574
[Journal Article] Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome2018
- Author(s)
  Shioda Norifumi、Yabuki Yasushi、Yamaguchi Kouya、Onozato Misaki、Li Yue、Kurosawa Kenji、Tanabe Hideyuki、Okamoto Nobuhiko、Era Takumi、Sugiyama Hiroshi、Wada Takahito、Fukunaga Kohji
- Journal Title
  
  Nature Medicine
  
  Volume: 24 Issue: 6 Pages: 802-813
- DOI
  10.1038/s41591-018-0018-6
- NAID
  120006488578
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-16K08265, KAKENHI-PROJECT-16H06356
[Journal Article] The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.2018
- Author(s)
  Izumi H, Shinoda Y, Saito T, Saido TC, Sato K, Yabuki Y, Matsumoto Y, Kanemitsu Y, Tomioka Y, Abolhassani N, Nakabeppu Y, Fukunaga K.
- Journal Title
  
  Neuroscience.
  
  Volume: 377 Pages: 87-97
- DOI
  10.1016/j.neuroscience.2018.02.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15456, KAKENHI-PROJECT-17H01391, KAKENHI-PROJECT-16J02855, KAKENHI-PROJECT-16K20909, KAKENHI-PROJECT-16H05219
[Journal Article] Reduced CaM Kinase II and CaM Kinase IV Activities Underlie Cognitive Deficits in NCKX2 Heterozygous Mice.2018
- Author(s)
  Moriguchi S, Kita S, Yabuki Y, Inagaki R, Izumi H, Sasaki Y, Tagashira H, Horie K, Takeda J, Iwamoto T, Fukunaga K.
- Journal Title
  
  Mol Neurobiol.
  
  Volume: 55(5) Pages: 3889-3900
- DOI
  10.1007/s12035-017-0596-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08610, KAKENHI-PROJECT-16K19024, KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-15K08583, KAKENHI-PROJECT-16K14574, KAKENHI-PROJECT-16K08565
[Journal Article] Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2+ channel enhancer.2017
- Author(s)
  Yabuki Y, Matsuo K, Izumi H, Haga H, Yoshida T, Wakamori M, Kakehi A, Sakimura K, Fukuda T, Fukunaga K.
- Journal Title
  
  Neuropharmacology.
  
  Volume: 117 Pages: 1-13
- DOI
  10.1016/j.neuropharm.2017.01.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04650, KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-15H06036, KAKENHI-PROJECT-15K11036, KAKENHI-PROJECT-15K15681, KAKENHI-PROJECT-16K14574
[Journal Article] Combined Memantine and Donepezil Treatment Improves Behavioral and Psychological Symptoms of Dementia-Like Behaviors in Olfactory Bulbectomized Mice.2017
- Author(s)
  Yabuki Y, Matsuo K, Hirano K, Shinoda Y, Moriguchi S, Fukunaga K.
- Journal Title
  
  Pharmacology
  
  Volume: 99 Issue: 3-4 Pages: 160-171
- DOI
  10.1159/000452839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06036, KAKENHI-PROJECT-16K14574, KAKENHI-PROJECT-16H05219
[Journal Article] Novel spiroimidazopyridine derivative SAK3 improves methimazole-induced cognitive deficits in mice.2017
- Author(s)
  Noreen H, Yabuki Y, Fukunaga K.
- Journal Title
  
  Neurochem Int.
  
  Volume: - Pages: 91-99
- DOI
  10.1016/j.neuint.2017.03.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-15H06036, KAKENHI-PROJECT-16K14574
[Journal Article] Combined l-citrulline and glutathione administration prevents neuronal cell death following transient brain ischemia.2017
- Author(s)
  Matsuo K, Yabuki Y, Fukunaga K.
- Journal Title
  
  Brain Res.
  
  Volume: 1663 Pages: 123-131
- DOI
  10.1016/j.brainres.2017.03.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-15H06036, KAKENHI-PROJECT-16K14574
[Journal Article] Trans-fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway.2017
- Author(s)
  Hirata, Y., Takahashi, M., Kudoh, Y., Kano, K., Kawana, H., Makide, K., Shinoda, Y., Yabuki, Y., Fukunaga, K., Aoki, J., Noguchi, T., Matsuzawa, A.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 印刷中 Issue: 20 Pages: 8174-8185
- DOI
  10.1074/jbc.m116.771519
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01168, KAKENHI-PUBLICLY-15H01391, KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-15H06036, KAKENHI-PROJECT-26293011, KAKENHI-PROJECT-15K18856, KAKENHI-PROJECT-16K14574, KAKENHI-PUBLICLY-17H05518, KAKENHI-PROJECT-16K15146
[Journal Article] The T-type calcium channel enhancer SAK3 inhibits neuronal death following transient brain ischemia via nicotinic acetylcholine receptor stimulation.2017
- Author(s)
  Yabuki Y, Jing X, Fukunaga K.
- Journal Title
  
  Neurochem Int.
  
  Volume: 108 Pages: 272-281
- DOI
  10.1016/j.neuint.2017.04.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15456, KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-16K14574
[Journal Article] Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy.2016
- Author(s)
  Moriguchi S, Ishizuka T, Yabuki Y, Shioda N, Sasaki Y, Tagashira H, Yawo H, Yeh JZ, Sakagami H, Narahashi T, Fukunaga K.
- Journal Title
  
  Mol Psychiatry.
  
  Volume: 印刷中 Issue: 2 Pages: 211-221
- DOI
  10.1038/mp.2016.187
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01413, KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-15H06036, KAKENHI-PROJECT-15K15025, KAKENHI-PROJECT-15K08583, KAKENHI-PROJECT-16K14574, KAKENHI-PROJECT-16K19024, KAKENHI-PROJECT-16K08265, KAKENHI-PROJECT-25250001
[Journal Article] Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons.2016
- Author(s)
  Shioda N*, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabe M, Sasahara M, Fukunaga K
- Journal Title
  
  Molecular Psychiatry
  
  Volume: 印刷中 Issue: 8 Pages: 1205-1222
- DOI
  10.1038/mp.2016.200
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06568, KAKENHI-PROJECT-15H04275, KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-15H06036, KAKENHI-PROJECT-25293093, KAKENHI-PROJECT-26290029, KAKENHI-PROJECT-16K14574, KAKENHI-PROJECT-16K14579, KAKENHI-PROJECT-16K08265, KAKENHI-PUBLICLY-16H01606, KAKENHI-PROJECT-16H06276
[Journal Article] ehydroepiandrosterone administration improves memory deficits following transient brain ischemia through sigma-1 receptor stimulation.2015
- Author(s)
  Yabuki Y, Shinoda Y, Izumi H, Ikuno T, Shioda N, Fukunaga K.
- Journal Title
  
  Brain Reｓｅａｒｃｈ
  
  Volume: 1622 Pages: 102-113
- DOI
  10.1016/j.brainres.2015.05.006
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26102704, KAKENHI-PROJECT-15H06036, KAKENHI-PROJECT-25460090, KAKENHI-PROJECT-25293124
[Journal Article] Stimulation of Sigma-1 Receptor Ameliorates Depressive-like Behaviors in CaMKIV Null Mice.2015
- Author(s)
  Moriguchi, S.;Sakagami, H.;Yabuki, Y.;Sasaki, Y.;Izumi, H.;Zhang, C.;Han, F.;Fukunaga, K.
- Journal Title
  
  Mol Neurobiol
  
  Volume: 52 Issue: 3 Pages: 1210-1222
- DOI
  10.1007/s12035-014-8923-2
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PUBLICLY-26102704, KAKENHI-PROJECT-15H04672, KAKENHI-PROJECT-15H06036, KAKENHI-PROJECT-25293124
[Presentation] プリオン性タンパク質凝集機構の解明と創薬応用に関する薬理学的研究2024
- Author(s)
  矢吹　悌
- Organizer
  第144回日本薬理学会近畿部会第39回日本薬理学会学術奨励賞受賞講演
- Invited
- Data Source
  KAKENHI-PLANNED-23H03851
[Presentation] RNA 相分離による α-シヌクレイン凝集が神経変性を誘導する2023
- Author(s)
  矢吹　悌、松尾　和哉、前田　康平、工藤　健太、堀　かりん、塩田　倫史
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNA 相分離を起点としたシヌクレイノパチー発症機序の解明2023
- Author(s)
  矢吹　悌、塩田　倫史
- Organizer
  第17回日本臨床ストレス応答学会大会シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] 多様なアミロイド凝集体による神経変性メカニズムの解明（シンポジウム企画）2023
- Author(s)
  村上一馬、小野賢二郎、矢吹悌、中山隆宏
- Organizer
  第64回日本神経病理学会総会学術研究会／第66回日本神経化学会大会合同大会
- Invited
- Data Source
  KAKENHI-ORGANIZER-23H03849
[Presentation] RNA 相分離を起点としたシヌクレイノパチー発症機序の解明2023
- Author(s)
  矢吹　悌、塩田　倫史
- Organizer
  第17回日本臨床ストレス応答学会大会シンポジウム
- Data Source
  KAKENHI-PLANNED-23H03851
[Presentation] Targeting therapy to expanded DNA using pyrrole-imidazole polyamides in repeat expansion diseases.2023
- Author(s)
  Kenta Kudo, Karin Hori, Kazuya Matsuo, Yasushi Yabuki and Norifumi Shioda
- Organizer
  20th International Workshop on Fragile X & Other Neurodevelopmental Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23H03851
[Presentation] The mechanism of α-Synuclein aggregation induced by RNA phase transition.2023
- Author(s)
  Yasushi Yabuki, Kazuya Matsuo, Norifumi Shioda
- Organizer
  第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会
- Data Source
  KAKENHI-PLANNED-23H03851
[Presentation] RNA 相分離による神経変性メカニズムの解明2023
- Author(s)
  矢吹　悌、塩田　倫史
- Organizer
  第76回日本薬理学会西南部会　次世代薬理学セミナー
- Data Source
  KAKENHI-PLANNED-23H03851
[Presentation] RNA 相転移による α-シヌクレイン凝集メカニズムの解明2023
- Author(s)
  矢吹　悌, 松尾　和哉, 塩田　倫史
- Organizer
  第 2 回ダウン症基礎研究会
- Data Source
  KAKENHI-PLANNED-23H03851
[Presentation] Targeting therapy to expanded DNA using pyrrole-imidazole polyamides in repeat expansion diseases.2023
- Author(s)
  Kenta Kudo, Karin Hori, Kazuya Matsuo, Yasushi Yabuki and Norifumi Shioda
- Organizer
  20th International Workshop on Fragile X & Other Neurodevelopmental Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNA 相転移による α-シヌクレイン凝集メカニズムの解明2023
- Author(s)
  矢吹　悌, 松尾　和哉, 塩田　倫史
- Organizer
  第 2 回ダウン症基礎研究会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNA 相分離による神経変性メカニズムの解明2023
- Author(s)
  矢吹　悌、塩田　倫史
- Organizer
  第76回日本薬理学会西南部会　次世代薬理学セミナー
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] The mechanism of α-Synuclein aggregation induced by RNA phase transition.2023
- Author(s)
  Yasushi Yabuki, Kazuya Matsuo, Norifumi Shioda
- Organizer
  第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] CAG/CTGトリプレットリピート病における環状ピロール-イミダゾールポリアミドを用いた伸長DNA標的治療法の開発2022
- Author(s)
  川久保厚佑、池ノ下侑、松尾和哉、朝光世煌、矢吹悌、杉山弘、塩田倫史
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] Cellular stress-induced formation of RNA G-quadruprexes accelerates α-Synuclein aggregation.2022
- Author(s)
  前田康平、矢吹悌、朝光世煌、松尾和哉、溝端知宏、河田康志、塩田倫史
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNA 相転移による α-シヌクレイン凝集促進機構の検討2022
- Author(s)
  矢吹悌、松尾和哉、前田康平、溝端知宏、川久保厚佑、塩田倫史
- Organizer
  令和4年度日本生化学会九州支部例会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNA phase transition disrupts α-Synuclein proteostasis.2022
- Author(s)
  Yasushi Yabuki, Kazuya Matsuo, Norifumi Shioda
- Organizer
  第17回生命医科学研究所ネットワーク国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNA 相転移によるシヌクレイノパチー病態解明と治療戦略2022
- Author(s)
  矢吹悌、塩田倫史
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNA G-quadruplex promotes phase transition of prion-like proteins.2022
- Author(s)
  Yasushi Yabuki, Kazuya Matsuo, Kohei Maeda, Yusuke Sakai, Tomohiro Mizobata, Norifumi Shioda
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] NA 相転移に着目した神経変性疾患発症メカニズムの解明2022
- Author(s)
  矢吹悌、塩田倫史
- Organizer
  第95回日本生化学大会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNA 相転移による α-シヌクレイン凝集体誘導メカニズム.2022
- Author(s)
  矢吹悌、松尾和哉、酒井勇輔、塩田倫史
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNA相転移によるプリオン性タンパク質凝集機構と創薬研究2022
- Author(s)
  矢吹悌、塩田倫史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNA グアニン四重鎖による α-シヌクレイン相転移促進メカニズム.2022
- Author(s)
  矢吹悌、松尾和哉、酒井勇輔、塩田倫史
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] ARX遺伝子GCGリピート伸長はRNAグアニン四重鎖を介してARXタンパク質の翻訳抑制を引き起こす2021
- Author(s)
  川久保厚佑、朝光世煌、矢吹悌、塩田倫史
- Organizer
  第94回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16369
[Presentation] RNAグアニン四重鎖は α-シヌクレインのゾル-ゲル相転移を誘導する2021
- Author(s)
  前田康平、矢吹悌、朝光世煌、松尾和哉、溝端知宏、河田康志、塩田倫史
- Organizer
  第74回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNAグアニン四重鎖はα-シヌクレインの液-固相転移を促進する2021
- Author(s)
  矢吹悌、前田康平、溝端知宏、河田康志、朝光世煌、塩田倫史
- Organizer
  第94回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16369
[Presentation] RNA グアニン四重鎖はα-シヌクレイン液-固相転移を誘起する2021
- Author(s)
  矢吹悌、朝光世煌、前田康平、松尾和哉、溝端知宏、河田康志、塩田倫史
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] 神経細胞におけるグアニン四重鎖RNA構造の相分離現象への寄与2021
- Author(s)
  朝光世煌、川嵜萌、廣瀬優希、矢吹悌、柏﨑玄伍、Anandhakumar Chandran、板東俊和、杉山弘、塩田倫史
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNA グアニン四重鎖はα-シヌクレインのプロテオスタシス破綻を誘導する2021
- Author(s)
  矢吹悌、朝光世煌、前田康平、松尾和哉、溝端知宏、河田康志、塩田倫史
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] RNAグアニン四重鎖はα-シヌクレイン相転移を誘導する2021
- Author(s)
  矢吹悌、松尾和哉、前田康平、溝端知宏、河田康志、朝光世煌、塩田倫史
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] 新規RNAG4結合タンパク質DNAPTP6の同定及びマウス脳における機能解析2021
- Author(s)
  川嵜萌、朝光世煌、矢吹悌、塩田倫史
- Organizer
  第94回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16369
[Presentation] RNAグアニン四重鎖はα-シヌクレイン相転移を誘導する2021
- Author(s)
  矢吹悌、朝光世煌、前田康平、松尾和哉、溝端知宏、河田康志、塩田倫史
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-21K06579
[Presentation] 神経薬理学的な T 型カルシウムチャネルの脳機能解析2019
- Author(s)
  矢吹　悌、塩田倫史、福永浩司
- Organizer
  次世代薬理セミナー2019 in 那覇
- Invited
- Data Source
  KAKENHI-PROJECT-19K16369
[Presentation] 脳における T 型カルシウムチャネルの役割2019
- Author(s)
  矢吹　悌
- Organizer
  日本薬学会東北支部　第18回生物化学若手研究者セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K16369
[Presentation] Discovery of disease-modifying drug inhibiting alpha-synuclein aggregation in Parkinson's disease model mice2018
- Author(s)
  Kohji Fukunaga, Yasushi Yabuki, Kazuya Matsuo, Hisanao Izumi, Yasuharu Shinoda
- Organizer
  WCP2018 KYOTO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] Preclinical studies of T-type calcium channel enhancer in Alzheimer's disease therapy2018
- Author(s)
  Kohji Fukunaga, Hisanao Izumi, Yasuharu Shinoda, Yasushi Yabuki
- Organizer
  WCP2018 KYOTO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] Mechanism underlying anti-depressive action of novel Alzheimer's disease therapeutic candidate, SAK32018
- Author(s)
  Kohji Fukunaga, Jing Xu, Mengze Yu, Yasushi Yabuki
- Organizer
  WCP2018 KYOTO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] Oxidative damage and mitochondrial dysfunction in valproic acid-exposed autism model rats2018
- Author(s)
  Kazuya Matsuo, Yasushi Yabuki, Kohji Fukunaga
- Organizer
  WCP2018 KYOTO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] Arachidonic acid treatment aggravates alpha-Synuclein aggregation in vitro and in situ2018
- Author(s)
  ○Kohji Fukunaga, Yasushi Yabuki, Kazuya Matsuo, Yasuharu Shinoda
- Organizer
  AD/PD 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] Mitochondrial dysfunction and oxidative stress in rat brain prenatally exposed to valproic acid2017
- Author(s)
  ○Kazuya Matsuo, Yasushi Yabuki, and Kohji Fukunaga
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] T 型カルシウムチャネルの神経薬理学的研究2017
- Author(s)
  矢吹　悌、福永　浩司
- Organizer
  生体機能と創薬シンポジウム2017
- Invited
- Data Source
  KAKENHI-PROJECT-17K15456
[Presentation] T 型カルシウムチャネル活性化薬SAK3は嗅球摘出マウスの海馬神経新生を促進する2017
- Author(s)
  矢吹悌、許晶、福永浩司
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15H06036
[Presentation] FABP3 deficiency impairs fear extinction memory2017
- Author(s)
  ○Yasushi Yabuki, Ibuki Takahata, Kazuya Mastuo, Yuji Owada, Kohji Fukunaga
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] FABP3 deficiency causes impaired fear extinction as PTSD-like behaviors2017
- Author(s)
  ○Yasushi Yabuki, Ibuki Takahata, Yuji Owada, Kohji Fukunaga
- Organizer
  第60回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] Arachidonic acid promotes alpha-synuclein oligomerization through fatty acid-binding proteins.2017
- Author(s)
  Kohji Fukunaga, Yasushi Yabuki, Yasuharu Shinoda, Hisanao Izumi
- Organizer
  The 13th International Conference on Alzheimer’s & Parkinson’s Diseases
- Place of Presentation
  Vienna, Austria
- Year and Date
  2017-03-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] Preclinical studies of T-type Calcium Channel Enhancer in Alzheimer’s Disease Therapy2017
- Author(s)
  Kohji Fukunaga, Hisanao Izumi, Yasuharu Shinoda, Yasushi Yabuki
- Organizer
  The 13th International Conference on Alzheimer’s & Parkinson’s Diseases
- Place of Presentation
  Vienna, Austria
- Year and Date
  2017-03-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] Memantine improves cognitive deficits in APP23 mice via KATP channel inhibition2017
- Author(s)
  ○Shigeki Moriguchi, Yasushi Yabuki, Kohji Fukunaga
- Organizer
  第60回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] T 型カルシウムチャネル活性化薬SAK3は嗅球摘出マウスの海馬神経新生を促進する2017
- Author(s)
  矢吹悌、許晶、福永浩司
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] T 型カルシウムチャネル賦活薬 SAK3 による神経新生促進作用2017
- Author(s)
  于　梦澤、許　晶、矢吹　悌、福永　浩司
- Organizer
  第68回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-17K15456
[Presentation] 脳における T 型カルシウムチャネル機能の解明を目指して2017
- Author(s)
  矢吹　悌、松尾　和哉、若森　実、福永　浩司
- Organizer
  第18回ブレインサイエンス研究会
- Data Source
  KAKENHI-PROJECT-17K15456
[Presentation] 胎生期バルプロ酸曝露による自閉症様行動とオキシトシンによる改2016
- Author(s)
  松尾和哉、矢吹悌、福永浩司
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  仙台
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] 一過性脳虚血発作が誘導する eNOS S-glutathionylation と L-シトルリン・グルタチオン併用投与による脳保護効果2016
- Author(s)
  矢吹悌、福永浩司
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  仙台
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] 胎生期バルプロ酸曝露による自閉症様行動に対するオキシトシンの改善作用2016
- Author(s)
  松尾　和哉、矢吹　悌、福永　浩司
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2016
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] S-glutathionylationn of endothelial nitric oxide synthase following transient brain ischemia.2016
- Author(s)
  Yasushi Yabuki, Kohji Fukunaga
- Organizer
  The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide - The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
- Place of Presentation
  仙台
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06036
[Presentation] MPTP 誘発パーキンソン病様症状に対するミトコドリア保護薬の効果2016
- Author(s)
  芳賀飛高、矢吹悌、福永浩司
- Organizer
  第27回霧島神経薬理フォーラム
- Place of Presentation
  福岡
- Year and Date
  2016-08-19
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] Cognitive improvement by SAK3 through T-type voltage gated Ca2+ channel stimulation2016
- Author(s)
  Yasushi Yabuki and Kohji Fukunaga
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15H06036
[Presentation] 海馬依存性記憶形成におけるT型カルシウムチャネルの関与2016
- Author(s)
  矢吹　悌、松尾　和哉、若森　実、福永　浩司
- Organizer
  第38回日本生物学的精神医学会・第59回日本神経化学会大会　合同年会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] バナジウム有機錯体 VO(OPT) 投与による脳虚血耐性誘導2016
- Author(s)
  高畑伊吹、矢吹悌、福永浩司
- Organizer
  第67回日本薬理学会北部会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] 一過性脳虚血発作が誘導する eNOS S-glutathionylation と L-シトルリン・グルタチオン併用投与による脳保護効果2016
- Author(s)
  矢吹悌、福永浩司
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  仙台
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-15H06036
[Presentation] 脂肪酸結合タンパク質は黒質ドパミン神経細胞におけαシヌクレイン凝集体形成に関与する2016
- Author(s)
  福永浩司、矢吹悌、塩田倫史
- Organizer
  第59回日本脳循環代謝学術集会
- Place of Presentation
  徳島
- Year and Date
  2016-11-11
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] T 型カルシウムチャネル活性化薬 SAK3 の神経保護作用2016
- Author(s)
  矢吹悌、許晶、福永浩司
- Organizer
  第59回日本脳循環代謝学術集会
- Place of Presentation
  徳島
- Year and Date
  2016-11-11
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] T 型 Ca2+ チャネル活性化作用を有する spiroimidazopyridine 化合物の生理活性評価2016
- Author(s)
  矢吹悌、福永浩司
- Organizer
  第68回日本細胞生物学会・第11回日本ケミカルバイオロジー学会合同大会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] アルツハイマー病治療候補薬SAK3の心毒性に関する研究2016
- Author(s)
  田原一樹、篠田康晴、矢吹悌、福永浩司
- Organizer
  第67回日本薬理学会北部会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] Reduced CaM kinase II and CaM kinase IV activities mediate cognitive deficits in NCKX2 heterozygous mice2016
- Author(s)
  森口茂樹、喜多紗斗美、矢吹悌、堀江恭二、竹田潤二、岩本隆宏、福永浩司
- Organizer
  第38回日本生物学的精神医学会・第59回日本神経化学会大会　合同年会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] 経口グルタチオン投与の脳血管性認知症の予防効果2016
- Author(s)
  福永浩司、矢吹悌
- Organizer
  第18回応用薬理シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] MPTP 誘発パーキンソン病様症状に対するピルビン酸エチルの改善作用2016
- Author(s)
  芳賀飛高、矢吹悌、福永浩司
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  仙台
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] T 型カルシウムチャネル活性化薬 SAK3 の神経保護作用2016
- Author(s)
  矢吹悌、許晶、福永浩司
- Organizer
  第59回日本脳循環代謝学術集会
- Place of Presentation
  徳島
- Year and Date
  2016-11-11
- Data Source
  KAKENHI-PROJECT-15H06036
[Presentation] PTSD-like behavior in FABP3 null mice and its improvement by melatonin agonist2016
- Author(s)
  福永浩司、矢吹悌、大和田裕二
- Organizer
  第38回日本生物学的精神医学会・第59回日本神経化学会大会　合同年会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] Preclinical Studies of SAK3, a T-type Calcium Channel Stimulator in APP23 mice and rats.2016
- Author(s)
  Kohji Fukunaga, Hisanao Izumi, Yasuharu Shinoda, Yasushi Yabuki
- Organizer
  CTAD2016 - Clinical Trials on Alzheimer's Disease
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-12-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] オキシトシン投与は胎生期バルプロ酸曝露による自閉症様行動を改善する2016
- Author(s)
  松尾和哉、矢吹悌、福永浩司
- Organizer
  第18回応用薬理シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] 海馬依存性記憶形成におけるT型カルシウムチャネルの関与2016
- Author(s)
  矢吹悌、松尾和哉、若森実、福永浩司
- Organizer
  第38回日本生物学的精神医学会・第59回日本神経化学会大会　合同年会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-15H06036
[Presentation] APP23マウスに対するアルツハイマー病治療候補薬SAK3の薬効と体内動態2016
- Author(s)
  泉久尚、矢吹悌、篠田康晴、福永浩司
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  仙台
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-16H05219
[Presentation] T 型 Ca2+ チャネル活性化作用を有する spiroimidazopyridine 化合物の生理活性評価2016
- Author(s)
  矢吹悌、福永浩司
- Organizer
  第68回日本細胞生物学会・第11回日本ケミカルバイオロジー学会合同大会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-15H06036
[Presentation] Alzheimer disease drug candidate SAK3 stimulates cav3.1 and cav3.3 t-type calcium channels.2015
- Author(s)
  Yasushi Yabuki, Minoru Wakamori, and Kohji Fukunaga
- Organizer
  Neuroscience 2015
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06036
[Presentation] Anxiety and PTSD-like behaviors in FABP3 null mice.2015
- Author(s)
  Yasushi Yabuki, Ibuki Takahata, Ryo Inagaki, Yuji Owada, Kohji Fukunaga
- Organizer
  第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
- Place of Presentation
  東京
- Year and Date
  2015-09-24
- Data Source
  KAKENHI-PROJECT-15H06036
[Presentation] Effect of a novel cognitive enhancer ST101 on decreased CaMKII activity in schizophrenia model rats.2015
- Author(s)
  Yasushi Yabuki and Kohji Fukunaga
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  埼玉
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-15H06036
[Presentation] T-type Ca2+ channel activation by spiroimidazopyridine compound.2015
- Author(s)
  Yasushi Yabuki, Minoru Wakamori, and Kohji Fukunaga
- Organizer
  Pharmaceutical Science Symposium 2015 in Sendai
- Place of Presentation
  仙台
- Year and Date
  2015-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06036

1. Fukunaga Kohji (90136721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 37 results
2. 村上一馬 (80571281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 小野賢二郎 (70377381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 中山隆宏 (00532821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 塩田倫史 (00374950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 松尾和哉 (10912371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Xu Jing

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. HIKIDA Takatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 崎村建司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 八尾寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 朝光世煌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 松沢厚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 森寿

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 青木茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 阪上洋行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 岩本隆宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 田頭秀章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yabuki Yasushi 矢吹 悌

YABUKI Yasushi 矢吹 悌

Research Projects

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核内液－液相分離環境破綻による神経細胞死メカニズムの解明Principal Investigator

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The establishment of switching on/off system of a non-canonical nucleic acid structure using optogeneticsPrincipal Investigator

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Supramolecular behavior and dynamic capture of meta-aggregates

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[Amyloid and nucleic acid structure] The formation and propagation of meta-aggregates by RNA phase transitionPrincipal Investigator

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G4RNA相分離による神経機能制御メカニズムの解明

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Regulation of alpha-synuclein aggregation and propagation by RNA G-quadruplexes.Principal Investigator

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Function of T-type calcium channel in stress-induced depressive-like behaviors in mice.Principal Investigator

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Drug discovery and neurochemical researches about T-type calcium channel in neurogenesis.Principal Investigator

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Drug development by investigation of a-synucelin aggregation mechanism through FABP

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Development of novel therapeutics for Parkinson disease by FABP3 ligandsPrincipal Investigator

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[Journal Article] Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with the neurological disorder CANVAS2024

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[Journal Article] RNA G-quadruplexes and calcium ions synergistically induce Tau phase transition<i>in vitro</i>2024

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[Journal Article] A cyclic pyrrole-imidazole polyamide reduces pathogenic RNA in CAG/CTG triplet repeat neurological disease models2023

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Yabuki Yasushi 矢吹悌

YABUKI Yasushi 矢吹悌