FUJIWARA Kenji 藤原研司

Researcher Number	80101088
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Affiliation (based on the past Project Information) *help	1994 – 2004: 埼玉医科大学, 医学部, 教授 1998: Saitama Medical School, Faculty of Medicine, Professor and Chairman, 医学部, 教授 1995: Saitama medical school : professor, 附属病院, 教授 1992 – 1993: 東京大学, 医学部(病), 講師 1990: University of Tokyo, Faculty of Medicine, Lecturer., 医学部・附属病院, 講師 … More 1987 – 1989: 東京大学, 医学部(病), 講師 1988: 東京大学, 医学部, 講師 1986: Tokyo University, Faculty of Medicine,, 医学部, 講師 1986: University of Tokyo, Faculty of Medicine, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator Osteopontin / 肝再生 / 劇症肝炎 / Cytokine / SNP / VEGF / 肝類洞内皮細胞 / 肝移植 / 類洞内皮細胞 / クッパー細胞 … More / liver regeneration / 肝細胞膜 / Superoxide / Macrophage / Collagen / Hepatic fibrosis / アラビアゴム / 超酸化物イオン / マクロファージ / コラゲン / 線維肝 / Hepatitis activity / Interferon / Auto immune hepatitis / Chronic hepatitis C / Th1 immune reaction / サイトカイン / オステオポンチン / 肝炎活動性 / インターフェロン / 自己免疫性肝炎 / C型慢性肝炎 / Th1免疫応答 / Transgenic mouse / Stellate cell / Kupffer cell / Sinusoidal endothelial cell / Microcirculatory disturbance / Liver transplantation / プロテオグリカン / ヘパリン / 微小循環 / pericyte / 肝移植後肝不全 / TIE受容体 / Angiopoietin / osteopontin / Tie受容体 / angiopoiein / 肝星細胞 / トランスジェニックマウス / オステオポチン / 星細胞 / 微小循環障害 / sinusoidal endothetial cells / Kupffer cells / sinusoidal fibrin doposition / acute liver failure / fulminant hepatitie / 肝マクロファージ / 組織因子 / トロンボモジュリン / primary graft nonfunction / 肝類洞内凝固 / 急性肝不全 / TGFbeta / Putrescine / Hepatocyte growth factor / Hepatocyte plasma membrane / TGFβ / プトレスシン / 肝細胞増殖因子 / polyamine / cultured hepatocyte / plasma membrane / ornithine decarboxylase / macrophage / intravascular coagulation / fulminant hepatitis / 肝再生促進因子 / 分子生物学 / オルニシン脱炭酵素 / ポリアミン代謝 / 培養肝細胞 / 内皮細胞 / オルニシン脱炭酸酵素 / マクロファ-ジ / 血管内凝固 … More Except Principal Investigator VEGF / COX-2 / 肝再生 / 上皮成長因子 / prostaglandin / PPAR / プロスタグランジン / マクロファージ / NFκB / TNF / Liver Regeneration / flk-1 / KDR / PDGF / PCPE / 肝星細胞 / TFPI / 肝類洞内皮細胞 / 肝細胞 / Platelet / Growth Factor / Epidermal Growth Factor / イムノアッセイ / 血小板 / 増殖因子 / Ornithine decarboxylase / Insulin / Glucagon / Exchange transfusion / Cytoprotection / Liver regeneration / Acute liver failure / インスリン・グルカゴン療法 / アンチトロンビン【III】 / 血管内凝固 / 交換輸血 / 肝障害 / プロスタグランヂン誘導体 / オルニチンデカルボキシラーゼ / 抗トロンビン【III】 / 血漿交換 / グルカゴン・インスリン療法 / 急性肝不全 / carcinogenesis / angiogenesis / cDNA microarray / Helicobacter pylori / gastric adenoma / gastric hyperplastic polyp / 胃癌 / 癌化 / 血管新生 / cDNAマイクロアレイ / ヘリコバクター・ピロリ / 胃腺腫 / 胃過形成性ポリープ / CIX-2 / colon cancer / PPARγ / 血管内皮増殖因子 / 受容体 / 大腸腺腫 / 大腸癌 / macrophage / hepatocyte / IAP (inhibitor of apoptosis protein) / apoptosis / 肝壊死 / エンドトキシン / D-galactosamine / IAP(inhibitor of apoptosis) / アポトーシス / ft-1 / Sinusoidal Endothelial Cells / Fulminant Hepatic Failure / fet-1 / flt-1 / 劇症肝炎 / Smooth Muscle α Actin / RNA-binding Protein / Hepatic Stellate Cell / TGFβ / bFGF / コラゲン / 平滑筋αアクチン / RNA結合蛋白 / Thrombomodulin / Sinusoidal endothelial cell / Liver failure / Liver transplantation / 類洞内皮細胞 / トロンボモジュリン / 肝不全 / 肝移植 / cell growth / plasma membrane / hepatocytes / 蛋白 / 肝細胞増殖 / 細胞増殖 / 肝細胞膜 Less

Genetic Polymorphisms in Promoter Regions of Osteopontin Gene as Host Factors to Determine Th1 Immune Reactions against Hepatitis Virus.Principal Investigator
- Principal Investigator
  
  FUJIWARA Kenji
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical School
Role of COX-2 in the development of gastric tumor by Helicobacter Pylori
- Principal Investigator
  
  ARAI Shin
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical School
Roles of cell surface membrane and nuclear prostaglandin receptors in growth factor production during colon carcinogenesis
- Principal Investigator
  
  OTA Shinichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical School
Study on Strategies for Non-Heart Beating LiverPrincipal Investigator
- Principal Investigator
  
  FUJIWARA Kenji
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical School
Mechanisms of Development of Massive Necrosis and Regeneration after Liver Injury Regulated by Activated Sinusoidal Macrophages
- Principal Investigator
  
  NAGOSHI Sumiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical School
The Mechanisms of Hepatic Stellate Cell Activation : Possible Contribution of Type I Procollagen C-Proteinase Enhancer Protein.
- Principal Investigator
  
  MATSUI Atsushi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical School
The Mechanisms of Impaired Liver Regeneration in Fulminant Hepatic Failure : The Significance of Sinusoidal Endothelial Cell Proliferation.
- Principal Investigator
  
  MOCHIDA Satoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical School
Anticoagulant Targeting the Hepatic Sinusoids for Liver Injury Following Orthotopic Liver Transplantation
- Principal Investigator
  
  MOCHIDA Satoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical School
New devices in anticoagulant therapy for massive hepatic necrosis through sinusoidal fibrin depositionPrincipal Investigator
- Principal Investigator
  
  FUJIWARA Kenji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical School
purification of growth stimulatory factor in rat liver plasma membrane
- Principal Investigator
  
  HIRATA Keiichi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
Purification of hepatocyte comitogenic factor in plasma membrane and its action site (s) in hepatocyte proliferation.Principal Investigator
- Principal Investigator
  
  FUJIWARA Kenji
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
Factors Associated with Insufficient Liver Regeneration in Fulminant Hepatic FailurePrincipal Investigator
- Principal Investigator
  
  FUJIWARA Kenji
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
Platelet Epidermal Growth Factor and Liver Regeneration
- Principal Investigator
  
  IKEDA Hitoshi, 岡裕爾
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
ROLE OF SUPEROXIDE FROM MACROPHAGES IN HEPATIC FIBROSISPrincipal Investigator
- Principal Investigator
  
  FUJIWARA Kenji
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tokyo
TREATMENT OF ACUTE LIVER FAILURE BY STIMULATION OF LIVER REGENERATION AND CYTOPROTECTION
- Principal Investigator
  
  OKA Hiroshi
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo University

All 2004 2003 Other

All Journal Article Patent

[Journal Article] Plasma Osteopontin Levels in Patients with Fulminant Hepatitis2004
- Author(s)
  Matsui A, Mochida S, Ohno A, Nagoshi S, Hirose T, Fujiwara K
- Journal Title
  
  Hepatology Res 22
  
  Pages: 202-206
- NAID
  10018024812
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370191
[Journal Article] Genetic Polymorphisms in Promoter Region of Osteopontin Gene May be a Marker Reflecting Hepatitis Activity in Chronic Hepatitis C Patients2004
- Author(s)
  Mochida S, Hashimoto M, Matsui A, Naito M, Inao M, Nagoshi S, Egashira T, Mishiro S, Fujiwara K
- Journal Title
  
  Biochem Biophys Res Commun 313
  
  Pages: 1079-1085
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370191
[Journal Article] Transgenic Mice Expressing Osteopontin in Hepatocytes as a Model of Autoimmune Hepatitis2004
- Author(s)
  Mochida S, Yamamoto T, Mimura S, Matsui A, Ohno A, Koh H, Saitoh E, Nagoshi S, Fujiwara K
- Journal Title
  
  Biochem Biophys Res Commun 317
  
  Pages: 114-120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370191
[Journal Article] Extrahepatic manifestation in Transgenic Mice of Osteopontin in Hepatocytes : A Clue to Advent of Pathological State in Various Organs of Chronic Hepatitis C Patients
- Author(s)
  Saitoh E, Matsui A, Inao M, Mimura S, Koh H, Ohno A, Nagoshi S, Kayano H, Yoshimoto T, Mochida S, Fujiwara K
- Journal Title
  
  Hepatol Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370191
[Journal Article] SNPs in the Promoter Region of Osteopontin Gene as a Marker Predicting the Efficacy of Interferon-Based Therapies in Chronic Hepatitis C
- Author(s)
  Naito M, Matsui A, Inao M, Nagoshi S, Nagano M, Ito N, Egashira T, Hashimoto M, Mishiro S, Mochida S, Fujiwara K
- Journal Title
  
  J Gastroenterol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370191
[Journal Article] Increased Cytoprotective Function in the Liver of Transgenic Mice Expressing Osteopontin in Hepatocytes
- Author(s)
  Koh H, Matsui A, Mimura S, Inao M, Saitoh E, Ohno A, Nagoshi S, Yoshimoto T, Mochida S, Fujiwara K
- Journal Title
  
  Hepatol Res (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370191
[Patent] 感染による病変の程度を予測するためのデータを収集する方法2003
- Inventor(s)
  持田智, 藤原研司, 三代俊治, 他
- Industrial Property Rights Holder
  株式会社東芝
- Filing Date
  2003-09-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370191
[Patent] 感染による病変の程度を予測するためのデータを収集する方法2003
- Inventor(s)
  持田智, 藤原研司, 三代俊治, 他
- Industrial Property Rights Holder
  株式会社東芝
- Filing Date
  2003-09-24
- Data Source
  KAKENHI-PROJECT-14370191

1. MOCHIDA Satoshi (20219968)

# of Collaborated Projects: 7 results

# of Collaborated Products: 6 results
2. NAGOSHI Sumiko (50306271)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
3. INAO Mie (70286037)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
4. MATSUI Atsushi (40260484)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
5. OGATA Itsuo (80169169)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. TOMIYA Tomoaki (90227637)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. HIRATA Keiichi (50199064)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. OTA Shinichi (30185269)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. ARAI Shin (20306294)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. OKA Yuji (20160658)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. OHTA Yasuhiko (60124666)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. IKEDA Hitoshi (80202422)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. YAMANOBE Fumio (90286097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. OKA Hiroshi (10010258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 佐藤譲

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SATO Yuzuru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

FUJIWARA Kenji 藤原 研司

Research Projects

Research Products

Co-Researchers

Genetic Polymorphisms in Promoter Regions of Osteopontin Gene as Host Factors to Determine Th1 Immune Reactions against Hepatitis Virus.Principal Investigator

Principal Investigator

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Research Institution

Principal Investigator

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Principal Investigator

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Study on Strategies for Non-Heart Beating LiverPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

New devices in anticoagulant therapy for massive hepatic necrosis through sinusoidal fibrin depositionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Purification of hepatocyte comitogenic factor in plasma membrane and its action site (s) in hepatocyte proliferation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Factors Associated with Insufficient Liver Regeneration in Fulminant Hepatic FailurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ROLE OF SUPEROXIDE FROM MACROPHAGES IN HEPATIC FIBROSISPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

FUJIWARA Kenji 藤原研司