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HAZEKI Osamu  櫨木 修

ORCIDConnect your ORCID iD *help
… Alternative Names

櫨樹 修  ハゼキ オサム

枦木 修  ハゼキ オサム

櫨木 修  ハゼキ オサム

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Researcher Number 80142751
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2013: 広島大学, 医歯薬保健学研究科, 教授
2013: 広島大学, 医歯薬保健学研究院, 教授
2012: 広島大学, 医歯薬保健学研究院(薬), 教授
2011: 広島大学, 医歯(薬)学総合研究科, 教授
2010: 広島大学, 医歯薬学総合研究科, 教授 … More
2009 – 2010: Hiroshima University, 大学院・医歯薬学総合研究科, 教授
2008: Hiroshima University, 医歯薬学総合研究科, 教授
2002 – 2005: HIROSHIMA UNIVERSITY, GRADUATE SCHOOL OF BIOMEDICALSC1ENCES, PROFESSOR, 大学院・医歯薬学総合研究科, 教授
1998 – 2001: Hiroshima University Faculty of Medicine Professor, 医学部, 教授
1998: 広島大学, 医学部・総合薬学学科, 教授
1997: 東京大学, 大学院・薬学系研究所, 助教授
1997: University of Tokyo, Graduate School of Pharmaceutical Sciences, Associate Professor, 大学院・薬学系研究科, 助教授
1996: Faculty of Pharmaceutical Sciences, University of Tokyo, 薬学部, 助教授
1995: The University of Tokyo, Faculty of Pharmaceutical Sciences, Dept.of Physiol.Che, 薬学部, 講師
1992 – 1994: 東京大学, 薬学部, 助手
1989 – 1990: 東京大学, 薬学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological pharmacy / Biological pharmacy / 代謝生物化学 / Functional biochemistry
Except Principal Investigator
Biological pharmacy / Functional biochemistry / 代謝生物化学 / Physical pharmacy / Chemical pharmacy / 応用薬理学・医療系薬学 / Virology
Keywords
Principal Investigator
ワ-トマニン / イノシトールリン脂質3-キナーゼ / G蛋白質 / イノシトールリン脂質3キナーゼ / チロシンリン酸化 / SYNERGISM / TYROSINE KINASE / チロシンキナーゼ / G-PROTEINS / PI 3-KINASE … More / WORTMANNIN / GTP結合タンパク質 / NEUTROPHILS / 好中球 / ザイモザン / イノシトールリン脂質 / p110β / SHIP-1 / phagocytosis / RAW264.7 / PTEN / shRNA / インスリン受容体 / プロテインキナーゼB / シグナル伝達 / PC12細胞 / PI3キナーゼ / ADENOSINE / BETAGAMMA SUBUNITS / INSULIN / PHOSPHOINOSITIDE 3-KINASE / 三量体型G蛋白質 / トランスアクティベーション / アデノシン / 相乗的活性化 / Gβγ / インスリン / METASTASIS / PROTEIN KINASE B / 阻害薬 / 癌転移 / 相乗効果 / ワートマニン / GLUCOSE UPTAKE / MEMBRANE RUFFLING / CELL SIGNALING / CHEMOATTRACTANT RECPTOR / INSULIN RECEPTOR / TYROSINE-PHOSPHORYLATION / 糖代謝 / 膜ラッフリング / 細胞内シグナル / 化学遊走因子受容体 / betagammaSUBUNITS / CTP -BINDING PROTEIN / PI3-KINASE / βγサブユニット / LIPOPOLYSACCHARIDE / GTP-BINDING PROTEIN / ADP-RIBOSYLATION / PERTUSSIS TOXIN / モノADアリボシル化 / モノADPリボシル化 / リポポリサッカライド / GTP結合蛋白質 / ADPリボシル化 / 百日咳毒素 / SHIP-2 / SHIP / 72-5ptase / 貪食 / macrophages / 5'-phosphatase / 4'-phosphatase / 3'-phosphatase / phosphoinositide / p110α / Class I PI3K / PI3K-CIIα / PIKFYVE / VPS34 / eGFP-FYVE / PtdIns(3)P / ファゴソーム / ファゴサイトーシス / RAW264.7細胞 / イノシトールリン脂質代謝 / 脂肪細胞 / セラミド / スフィンゴミエリナーゼ … More
Except Principal Investigator
CD38 / NAD / シグナル伝達 / signal transduction / 環状ADPリボース / 情報伝達 / Signal transduction / NADアーゼ / ADPリボシル化 / 百日咳毒素 / NADase / Membrane receptors / GTP-binding proteins / 細胞膜受容体 / GTP結合タンパク質 / エクト型酵素 / リンパ球 / G蛋白質 / イオンチャネル / ecto-enzyme / cyclic ADP-ribose / ヒトリンパ球表面抗原CD38 / ADP-ribosylation / チロシンリン酸化 / ワ-トマニン / GTP結合蛋白質 / CD9 / SHP-1 / retinoic acid / レチノイン酸 / NADアーゼ反応 / radioimmunoassay / ラジオイムノアッセイ / ADP-ribosyl cyclase / NAD-cleavage enzyme / カルシウムイオン / ADPリボース環化酵素 / NAD代謝酵素 / Adenylyl cyclase / アデニル酸シクラーゼ / Pertussis toxin / ホスホジエステラーゼ / PC-1 / アストロ細胞 / 化学遊走因子受容体 / イノシトールリン脂質3キナーゼ / 共役機構 / 低分子量GTP結合蛋白質 / imaging / molecular dynamics of cells / single molecular imagine / video-mass-scope / mass spectrometry / video-microscope / 1分子質量検出 / 1分子検出 / 画像解析 / 1細胞分析 / 1細胞質量分析 / イメージング / 細胞分子動態 / 1分子イメージング / ビデオマススコープ / 質量分析 / ビデオ顕微鏡 / HPLC / zinc complexes / polymer / molecularly imprinting / phosphorylated protein / kinase / intracellular signal transduction / 亜鉛鎖体 / リン酸化蛋白質 / 高速液体クロマトグラフィー / 亜鉛錯体 / ポリマー / モレキュラーインプリンティング / リン酸化タンパク質 / キナーゼ / 細胞内シグナル伝達 / mitochondria / ATP production / glucose oxidation / energy consumption / blood glucose level / senescence-accelerated prone mouse (SAMP8) / insulin signal transduction / aging / チロシンリン酸化タンパク質 / PI3-キナーゼ / SAMP8 / 老化促進モデルマウス / ミトコンドリア / ATP産生 / グルコース代謝 / エネルギー消費 / 血糖値 / 老化促進モデルマウス(SAMP8) / インスリンシグナル伝達系 / 老化 / Human obesity / 3T3-L1 adipocytes / Rat adipocytes / Leptin / Obese gene / TNF-α / 脂肪細胞 / インスリン分泌 / レプチン分泌 / 肥満 / ヒト肥満 / 3T3-L1脂肪細胞 / ラット脂肪細胞 / レプチン / 肥満抑制因子 / immune suppression / moesin / α3 β1 integrin / human CD46 / measles virus / 補体 / ホスファターゼ / IL-12 / 抗原提示細胞 / innate immunity(基本免疫) / 麻疹ウィルス / α_3β_1インテグリン / 免疫抑制 / Moesin / α3β1インテグリン / シグナル伝達分子 / ヒトCD46 / 麻疹ウイルス / cyclin ADP-ribose / 細胞内陥入 / nuclear receptor / cyclic DP-ribose / ADPリボース環化反応 / 核内受容体 / Tyrosine phosphorylation / G proteins / Cyclic ADP-ribose / リンパ球表面抗原CD38 / 環状チADPボ-ス / Wortmannin / Phosphatidyl inositol 3-kinase / イノシトール脂質3キナーゼ / calcium ion / Ion channels / Mastoparan / GTPase / 抗鬱薬 / ハチ毒 / GTPアーゼ / Nuclear transport / コレラ毒素 / 核内輸送 / adrenergic receptor / pertussis toxin / protein tyrosine phosphorylation / PI 3-kinase / wortmannin / cell adhesion / cell differentiation / heterotrimeric G proteins / 3T3細胞 / HL-60細胞 / 細胞分化 / 肝蔵細胞 / Caチャネル / Gq / Gs / alpha_1アドレナリン受容体 / betaアドレナリン受容体 / 肝臓初代培養 / 3量体G蛋白質 / 細胞接着 / チロシンキナーゼ / PI-3-キナーゼ / 細胞増殖 / 食細胞 / 肝臓細胞 / 細胞内シグナル / インスリン受容体 / イノシトールリン脂質3-キナーゼ / RT6 / NDPキナ-ゼ / 受容性 / トランスメンブランコントロ-ル / NDPキナーゼ / 受容体 / トランスメンブランコントロール Less
  • Research Projects

    (34 results)
  • Research Products

    (47 results)
  • Co-Researchers

    (35 People)
  •  Vesicle trafficking in phosphoinositide phosphatase-knockdown cellsPrincipal Investigator

    • Principal Investigator
      HAZEKI Osamu
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hiroshima University
  •  Construction of a Bank of the Cells Lacking Phosphoinositide-Metabolizing EnzymesPrincipal Investigator

    • Principal Investigator
      HAZEKI Osamu
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hiroshima University
  •  Develapment of Single Molecular Mass Spectrometry and Imaging Method

    • Principal Investigator
      MASUJIMA Thutomu
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      Hiroshima University
  •  Development of Solid-State Polymer for Selective Recognition of Phosphorylated Intracellular Signalling Enzymes

    • Principal Investigator
      AOKI Shln
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  SYNERGISTIC REGULATION OF PHOSPHOINOSITIDE 3-KINASEPrincipal Investigator

    • Principal Investigator
      HAZEKI Osamu
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Role of Insulin Signal Transduction on the Regulation of Senescence

    • Principal Investigator
      KUROKAWA Tomonori
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Mechanism of immune suppression induced by measles virus

    • Principal Investigator
      SEYA Tsukasa
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Virology
    • Research Institution
      OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES
  •  Importance of obese gene product, leptin in physiological significance and application of therapeutics

    • Principal Investigator
      TOKUMITSU Yukiko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  細胞の増殖・分化におけるイノシトールリン脂質3キナーゼの役割

    • Principal Investigator
      堅田 利明
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  神経細胞の分化調節におけるリン脂質代謝酵素の役割Principal Investigator

    • Principal Investigator
      櫨木 修
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  プロテインキナーゼカスケードにおけるワ-トマニン感受性標的分子の探索Principal Investigator

    • Principal Investigator
      櫨木 修
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  細胞外シグナルを制御する新しいプリンヌクレオチド代謝酵素

    • Principal Investigator
      堅田 利明
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  インスリンに対する細胞応答を増強するG蛋白質の作用機構の解析Principal Investigator

    • Principal Investigator
      櫨木 修
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokyo
  •  Physiological functions of the cell surface antigen CD38

    • Principal Investigator
      KATADA Toshiaki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokyo (Graduate School of Pharmaceutical Sciences)
  •  Physiological functions of a novel family of nucleotide-metabolizing enzymes

    • Principal Investigator
      KATADA Toshiaki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokyo
  •  Use of Wortmannin and its Derivatives for the Study on Phosphoinositide 3-KinasePrincipal Investigator

    • Principal Investigator
      HIZEKI Osamu
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
      The University of Tokyo
  •  細胞の増殖・分化におけるイノシトールリン脂質3キナーゼの役割

    • Principal Investigator
      堅田 利明
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  神経細胞の分化調節におけるリン脂質代謝の役割Principal Investigator

    • Principal Investigator
      櫨木 修
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  成熟リンパ球に発現するADPリボシル化酵素RT6の生理的役割の解明

    • Principal Investigator
      堅田 利明
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  Study on the Regulation and Function of Phosphoinositide 3-KinasesPrincipal Investigator

    • Principal Investigator
      HAZEKI Osamu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      University of Tokyo
  •  Analysis of New NAD-cleavage Enzymes Involved in Signal Transduction System

    • Principal Investigator
      KATADA Toshiaki
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokyo (Faculty of Pharmaceutical Sciences)
  •  Assay of Cyclic ADP-ribose and Analysis of Its Target Molecules

    • Principal Investigator
      KATADA Toshiaki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo(Faculty of Pharmaceutical Sciences)
  •  神経細胞の分化調節における細胞膜リン脂質代謝変化の役割Principal Investigator

    • Principal Investigator
      櫨木 修
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Regulation of adenylyl cyclase by GTP-binding Proteins

    • Principal Investigator
      KATADA Toshiaki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      University of Tokyo
  •  Analysis of NAD-cleavage Enzymes Involved in Signal Transduction System

    • Principal Investigator
      KATADA Toshiaki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokyo (Faculty of Pharmaceutical Sciences)
  •  Development of Assay Methods for a Novel Intracellular Messenger, Cyclic ADP-ribose

    • Principal Investigator
      KATADA Toshiaki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo (Faculty of Pharmaceutical Sciences)
  •  A Study on an Intracellular Signaling Molecule, Phosphinositide 3-KinasePrincipal Investigator

    • Principal Investigator
      HAZEKI Osamu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      University of Tokyo
  •  Regulation of ion channels by GTP-binding Proteins

    • Principal Investigator
      KATADA Toshiaki
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      University of Tokyo
  •  Signal Transduction Systems for Cell Proliferation, Differentiation and Adhesion with Emphasis upon the Role of GTP-binding Proteins

    • Principal Investigator
      UI Michio
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      代謝生物化学
    • Research Institution
      The Institute of Physical and Chemical Chemical Research (RIKEN)
      The University of Tokyo
  •  Regulation of the Functions of GTP-binding Proteins

    • Principal Investigator
      KATADA Toshiaki
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      代謝生物化学
    • Research Institution
      The University of Tokyo (Faculty of Phamaceutical Sciences)
      Tokyo Institute of Technology
  •  Development of Drug Screening Methods Using the Activities of GTP-binding Proteins

    • Principal Investigator
      KATADA Toshiaki
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo (Faculty of Pharmaceutical Sciences)
      Tokyo Institute of Technology
  •  A search with Pertussis Toxin for Cellular Factors Affecting the Properties of GTP-Binding ProteinPrincipal Investigator

    • Principal Investigator
      HAZEKI Osamu
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      代謝生物化学
    • Research Institution
      University of Tokyo
  •  トランスメンブランコントロ-ルにおけるGTP結合蛋白質の役割

    • Principal Investigator
      野村 靖幸
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  トランスメンブランコントロールにおけるGTP結合蛋白質の役割

    • Principal Investigator
      野村 靖幸
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University

All 2013 2012 2011 2010 2009 2008 2005 Other

All Journal Article Presentation

  • [Journal Article] PIKfyve regulates the endosomal localization of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responses2013

    • Author(s)
      Hazeki K, Uehara M, Nigorikawa K, Hazeki O
    • Journal Title

      PLoS One

      Volume: 8 Issue: 9 Pages: e73894-e73894

    • DOI

      10.1371/journal.pone.0073894

    • Data Source
      KAKENHI-PROJECT-23590078
  • [Journal Article] PIKfyve regulates the endosomal locali- zation of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responses2013

    • Author(s)
      Hazeki K, Uehara M, Nigorikawa K, Hazeki O
    • Journal Title

      PLoS One

      Volume: 8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Journal Article] Class-IA Phosphoinositide 3-Kinase p110<I>&beta;</I> Triggers GPCR-Induced Superoxide Production in p110<I>&gamma;</I>-Deficient Murine Neutrophils2012

    • Author(s)
      Nigorikawa K
    • Journal Title

      J Pharmacol Sci

      Volume: 120 Issue: 4 Pages: 270-279

    • DOI

      10.1254/jphs.12134FP

    • NAID

      10031147575

    • ISSN
      1347-8613, 1347-8648
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590065, KAKENHI-PROJECT-23590078
  • [Journal Article] Class-IA phospho- inositide 3-kinase p110βtriggers GPCR- induced superoxide production in p110γ-deficient murine neutrophils2012

    • Author(s)
      Nigorikawa K, Hazeki K, Kumazawa T, Itoh Y, Hoshi M, Hazeki O
    • Journal Title

      J Pharmacol Sci

      Volume: 120 Pages: 270-279

    • NAID

      10031147575

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Journal Article] Essential roles of PIKfyve and PTEN on phagosomal phosphati- dylinositol 3-phosphate dynamics2012

    • Author(s)
      Hazeki K, Nigorikawa K, Takaba Y, Segawa T, Nukuda A, Masuda A, Ishikawa Y, Kubota K, Takasuga S, Hazeki O
    • Journal Title

      FEBS Lett

      Volume: 586 Pages: 4010-4015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Journal Article] Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics2012

    • Author(s)
      Hazeki K.
    • Journal Title

      FEBS Lett

      Volume: 586 Issue: 22 Pages: 4010-4015

    • DOI

      10.1016/j.febslet.2012.09.043

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590065, KAKENHI-PROJECT-23590078, KAKENHI-PROJECT-24659124
  • [Journal Article] C5a controls TLR-induced IL-10 and IL-12 production independent of phosphatidyllinositol 3-kinase2011

    • Author(s)
      Okazaki N, Hazeki K, Izumi T, Nigorikawa K, Hazeki O
    • Journal Title

      J Biochem 149

      Pages: 265-274

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Journal Article] Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages2011

    • Author(s)
      Hazeki, K., Kametani, Y., et al, (11名中7番目)
    • Journal Title

      PLoS One.

      Volume: 6 Issue: 10 Pages: e26836-e26836

    • DOI

      10.1371/journal.pone.0026836

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200075, KAKENHI-PROJECT-21200079, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-22590065, KAKENHI-PROJECT-22790055, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590078, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24659214
  • [Journal Article] Phosphoinositide 3-kinaseγcontrols the intracellular localization of CpG to limit DNA-PKcsdependent IL-10 production in macrophages2011

    • Author(s)
      Hazeki K, Kametani Y, Murakami H, Uehara M, Ishikawa Y, Nigorikawa K, Takasuga S, Sasaki T, Seya T, Matsumoto M, Hazeki O
    • Journal Title

      PLoS ONE

      Volume: 6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Journal Article] Acute effect of melatonin and its time of administration on core body temperature and heart rate in cynomolgus monkeys2010

    • Author(s)
      Inui Y, Hazeki O
    • Journal Title

      J Toxicol Sci 35

      Pages: 383-391

    • NAID

      10026469845

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Journal Article] Acute effect of melatonin and its time of administration on core body temperature and heart rate in cynomolgus monkeys2010

    • Author(s)
      Inui Y, Hazeki O
    • Journal Title

      J Toxicol Sci

      Volume: 35 Pages: 383-391

    • NAID

      10026469845

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Journal Article] Specific role of phosphoinositide 3-kinase p110{alpha} in the regulation of phagocytosis and pinocytosis in macrophages2009

    • Author(s)
      Tamura N, Hazeki K, Okazaki N, Kametani Y, Murakami H, Takaba Y, Ishikawa Y, Nigorikawa K, Hazeki O
    • Journal Title

      Biochem J 423

      Pages: 99-108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Journal Article] Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effects in mouse sepsis model2009

    • Author(s)
      Takashima K, Matsunaga N, Yoshimatsu M, Hazeki K, Kaisho T, Uekata M, Hazeki O, Akira S, Iizawa Y, Ii M
    • Journal Title

      Br J Pharmacol 157

      Pages: 1250-1262

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Journal Article] Negative regulation of class IA phosphoinositide 3-kinase by protein kinase C{delto}l limits Fc{gamma} receptor-mediated phagocytosis in macrophages2009

    • Author(s)
      Hazeki K, et al.
    • Journal Title

      J Biochem 145

      Pages: 87-94

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Journal Article] Specific role for p85/p110β in GTP-binding protein-mediated activation of Akt2005

    • Author(s)
      H.Kubo, O.Hazeki他
    • Journal Title

      Biochem. J. 392

      Pages: 607-614

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15209001
  • [Journal Article] Specific role for p85/p110β in GTP-binding-protein-mediated activation of Akt2005

    • Author(s)
      H.Kubo, K.Hazeki, S.Takasuga, O.Hazeki
    • Journal Title

      Biochem. J. 392

      Pages: 607-614

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15209001
  • [Presentation] マクロファージの食胞におけるイノシトールリン脂質の挙動は貪食を受けた粒子のオプソニン化によって変化する2013

    • Author(s)
      温田晃子、櫨木薫、濁川清美、櫨木修
    • Organizer
      第52回日本薬学会
    • Place of Presentation
      中国四国支部学術大会(松山)
    • Year and Date
      2013-10-26
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] イノシトールリン脂質4位脱リン酸化酵素Inpp4aはマクロファージの機能を抑制的に制御する2013

    • Author(s)
      三宅美喜子、濁川清美、櫨木薫、瀬川智裕、温田晃子、大森弓緒、櫨木修
    • Organizer
      第52回日本薬学会
    • Place of Presentation
      中国四国支部学術大会(松山)
    • Year and Date
      2013-10-26
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] イノシトールリン脂質5位脱リン酸化酵素Inpp5eはマクロファージのFcγ受容体を介した貪食を抑制的に制御する2013

    • Author(s)
      瀬川智裕、櫨木薫、濁川清美、櫨木修
    • Organizer
      第52回日本薬学会
    • Place of Presentation
      中国四国支部学術大会(松山)
    • Year and Date
      2013-10-26
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] 食胞のホスファチジルイノシトール3-リン酸は主にPTENとPIKfyveによって除去される2012

    • Author(s)
      温田晃子、櫨木薫、濁川清美、益田彩加、櫨木修
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] PIKfyveによる非メチル化CpGの局在調節を介したTLR9シグナルの制御2012

    • Author(s)
      上原政文、櫨木薫、濁川清美、櫨木修
    • Organizer
      第51回日本薬学会中国四国支部学術大会
    • Place of Presentation
      松江
    • Year and Date
      2012-11-10
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] マクロファージによる感作赤血球の貪食におけるイノシトールリン脂質脱リン酸化酵素の役割の違い2012

    • Author(s)
      瀬川智裕、櫨木薫、濁川清美、林美里、三宅美喜子、櫨木修
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] マスト細胞の機能制御におけるクラス2型PI3Kの役割2012

    • Author(s)
      岡崎智子、濁川清美、櫨木薫、郭瑩、櫨木修
    • Organizer
      第51回日本薬学会中国四国支部学術大会
    • Place of Presentation
      松江
    • Year and Date
      2012-11-11
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] PI3Kγによる非メチル化CpGの細胞内局在とIL10産生の制御2011

    • Author(s)
      上原政文,櫨木薫,濁川清美,櫨木修
    • Organizer
      第50回日本薬学会中国四国支部学術大会
    • Place of Presentation
      高松
    • Year and Date
      2011-11-13
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] マクロファージの貪食機能に対するPI3Kサブタイプ特異的阻害薬の作用2011

    • Author(s)
      石川由紀、櫨木薫,濁川清美,櫨木修
    • Organizer
      第50回日本薬学会中国四国支部学術大会
    • Place of Presentation
      高松
    • Year and Date
      2011-11-13
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] マクロファージの貪食機能に対する PI3K サブタイプ特異的阻害薬の作用2011

    • Author(s)
      石川由紀、櫨木薫,濁川清美,櫨木修
    • Organizer
      第50回日本薬学会中国四国支部学術大会
    • Place of Presentation
      高松
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] PI3Kγによる非メチル化 CpG の細胞内局在と IL10 産生の制御2011

    • Author(s)
      上原政文,櫨木薫,濁川清美,櫨木修
    • Organizer
      第50回日本薬学会中国四国支部学術大会
    • Place of Presentation
      高松
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] マクロファージの貪食におけるイノシトールリン脂質の動態の解明2010

    • Author(s)
      高場雄貴、櫨木薫、櫨木修
    • Organizer
      第51回日本生化学会中国・四国支部例会
    • Place of Presentation
      山口
    • Year and Date
      2010-05-15
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] 好中球の活性酸素産生を制御するPI3-キナーゼサブタイプの解明2010

    • Author(s)
      熊澤崇, 濁川清美, 櫨木薫, 櫨木修
    • Organizer
      第51回日本生化学会中国・四国支部例会
    • Place of Presentation
      山口
    • Year and Date
      2010-05-15
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] マスト細胞のアレルギー反応におけるイノシトールリン脂質3キナーゼ(PI3K)の関与2009

    • Author(s)
      原里奈, 濁川清美, 櫨木薫, 櫨木修
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] Toll様受容体を介するIL-12産生におけるイノシトールリン脂質3キナーゼ(PI3K)のサブタイプ特異的な役割の解明2009

    • Author(s)
      泉達宏, 小縣旬, 亀谷由紀子, 濁川清美, 櫨木薫, 櫨木修
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] イノシトールリン脂質3キナーゼ(PI3K)γのCpG-DNA刺激に特異的な役割-IL-10産生の増強とIL-12産生の抑制2009

    • Author(s)
      亀谷由紀子, 泉達宏, 小縣旬, 濁川清美, 櫨木薫, 櫨木修
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] 好中球の活性酸素産生を制御するイノシトールリン脂質3キナーゼ(PI3K)アイソフォームの解明2009

    • Author(s)
      伊藤裕太、濁川清美、櫨木薫、櫨木修
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] 抗体依存性食作用に関与するイノシトールリン脂質3キナーゼのサブタイプの解明2009

    • Author(s)
      小縣旬, 濁川清美, 櫨木薫, 櫨木修
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] 好中球の活性酸素産生に関わるPI3-キナーゼのサブタイプの解明2009

    • Author(s)
      伊藤裕太、濁川清美、櫨木薫、櫨木修
    • Organizer
      第8回生命科学研究会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-26
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] マクロファージのエンドサイトーシスの制御における PI3K各サブタイプの役割2008

    • Author(s)
      田村奈美子、櫨木薫、濁川清美、櫨木修
    • Organizer
      第7回生命科学研究会
    • Place of Presentation
      別府
    • Year and Date
      2008-05-29
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] C5a inhibits LPS-induced IL-12 production by activation of phosphoinositide 3-kinase other than p110{gamma}2008

    • Author(s)
      岡崎夏実、櫨木薫、櫨木修
    • Organizer
      第38回日本免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-02
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] Differential regulation of phagocytosis, macropinocytosis and micropinocytosis by phosphoinositide 3-kinase p110{alpha} in macrophages2008

    • Author(s)
      田村奈美子、櫨木薫、櫨木修
    • Organizer
      第38回日本免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-03
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] (招待講演)Class IA型PI3-kinaseのサブタイプ特異的な機能2008

    • Author(s)
      櫨木修
    • Organizer
      千葉大学大学院薬学研究院特別講演
    • Place of Presentation
      千葉
    • Year and Date
      2008-07-24
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] (招待講演)ナフトキノン化合物のインスリンシグナル経路活性化作用2008

    • Author(s)
      櫨木修
    • Organizer
      生体キノン研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-26
    • Data Source
      KAKENHI-PROJECT-20590060
  • [Presentation] マクロファージの食胞におけるイノシトールリン脂質の挙動は貪食を受けた粒子のオプソニン化によって変化する

    • Author(s)
      温田晃子、櫨木薫、濁川清美、櫨木修
    • Organizer
      第52回日本薬学会中国四国支部学術大会
    • Place of Presentation
      松山
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] イノシトールリン脂質4位脱リン酸化酵素 Inpp4a はマクロファージの機能を抑制的に制御する

    • Author(s)
      三宅美喜子、濁川清美、櫨木薫、瀬川智裕、温田晃子、大森弓緒、櫨木修
    • Organizer
      第52回日本薬学会中国四国支部学術大会
    • Place of Presentation
      松山
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] イノシトールリン脂質5位脱リン酸化酵素 Inpp5e はマクロファージの Fcγ受容体を介した貪食を抑制的に制御する

    • Author(s)
      瀬川智裕、櫨木薫、濁川清美、櫨木修
    • Organizer
      第52回日本薬学会中国四国支部学術大会
    • Place of Presentation
      松山
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] マスト細胞の機能制御におけるクラス2型PI3Kの役割

    • Author(s)
      岡崎智子、濁川清美、櫨木薫、郭瑩、櫨木修
    • Organizer
      第51回日本薬学会中国四国支部学術大会
    • Place of Presentation
      松江
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] 食胞のホスファチジルイノシトール3-リン酸は主にPTENとPIKfyveによって除去される

    • Author(s)
      温田晃子、櫨木薫、濁川清美、益田彩加、櫨木修
    • Organizer
      日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] マクロファージによる感作赤血球の貪食におけるイノシトールリン脂質脱リン酸化酵素の役割の違い

    • Author(s)
      瀬川智裕、櫨木薫、濁川清美、林美里、三宅美喜子、櫨木修
    • Organizer
      日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23590078
  • [Presentation] PIKfyve による非メチル化 CpG の局在調節を介した TLR9 シグナルの制御

    • Author(s)
      上原政文、櫨木薫、 濁川清美、櫨木修
    • Organizer
      第51回日本薬学会中国四国支部学術大会
    • Place of Presentation
      松江
    • Data Source
      KAKENHI-PROJECT-23590078
  • 1.  HOSHINO Shin-ichi (40219168)
    # of Collaborated Projects: 22 results
    # of Collaborated Products: 0 results
  • 2.  KATADA Toshiaki (10088859)
    # of Collaborated Projects: 22 results
    # of Collaborated Products: 0 results
  • 3.  NISHINA Hiroshi (60212122)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 0 results
  • 4.  KUROKAWA Tomonori (00124793)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  KURACHI Yoshihisa (30142011)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  TAKAHASHI Katsunobu (40183850)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  OKAMURA Naoki (30144827)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  野村 靖幸 (00034041)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  高井 義美 (60093514)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  浅野 富子 (70100154)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  麻川 武雄 (50028362)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  多田 周右 (00216970)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  榎本 武美 (80107383)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  ISHIKAWA Yoshihiro
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  UI Michio (50001037)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  HAZEKI Kaoru (50146007)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  SEYA Tsukasa (10301805)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  TOKUMITSU Yukiko (60001046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  MURAKAMI Takeshi (50271656)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  MATSUOKA Ichiro (40157269)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  OKAJIMA Fumikazu (30142748)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  AOKI Shln (00222472)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  MASUJIMA Thutomu (10136054)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  HIRAKAWA Yasuyuki (80238344)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  SUGIYAMA Masanori (30106801)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  HASEGAWA Tomomi (10379886)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  柴崎 正勝 (30112767)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  木村 榮一 (30034010)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  新垣 知輝 (80314748)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  石井 孝司
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  KAPIL Mehta
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  FABIO Malava
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  MALAVASI Fabio
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  MEHTA Kapil
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  松本 美佐子
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

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