Kimura Tomoatsu 木村友厚

… Alternative Names

木村友厚キムラトモアツ

KIMURA Tomoatsu 木村友厚

TOMOATSU Kimura 木村友厚

KIMURA Tomoatu 木村友厚

Less

Researcher Number	80167379
Other IDs
External Links
Affiliation (Current)	2025: 四條畷学園大学, リハビリテーション学部, 教授
Affiliation (based on the past Project Information) *help	2018: 富山大学, 大学院医学薬学研究部(医学), 教授 2012 – 2016: 富山大学, 大学院医学薬学研究部(医学), 教授 2010: 富山大学, 大学院・医学薬学研究部(医学), 教授 2009 – 2010: University of Toyama, 大学院・医学薬学研究部, 教授 2008: University of Toyama, 大学院・医学薬学研究部(医学), 教授 … More 2007: University of Toyama, Dept. of Orthopaedic Surgery, Professor 2006: 富山大学, 大学院医学薬学研究部, 教授 2005: 富山大学, 医学部, 教授 1999 – 2004: 富山医科薬科大学, 医学部, 教授 1995: Medical School, Orthopaedic Surgery, Assistant Professor, 医学部, 助手 1992 – 1995: MD,Osaka University Medical School Department of Orthopedics, Lecturer, 医学部, 講師 1992: 大阪大学, 医学部整形外科, 講師 1988 – 1991: 大阪大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Orthopaedic surgery / Functional basic dentistry
Keywords	Principal Investigator 軟骨 / cartilage / コラーゲン / 遺伝子 / 修復 / collagen / repair / 変形性関節症 / 関節軟骨 / 間葉系細胞 … More / gene / トランスジェニックマウス / コラ-ゲン / 変性 / 椎間板 / 関節病学 / 異方性 / 細胞系譜 / 表層細胞 / 軟骨再生 / 再生 / 分化 / 起源 / 軟骨変性 / 軟骨細胞 / chondrocyte / differentiation / 滑膜 / 分化制御 / mesenchymal cell / 転写因子 / chondro dysplasia / transgenic mice / gene defect / 軟骨形成異常症 / 遺伝子異常 / osteoarthritis / transgenic mouse / 転写阻害 / 関節 / 環境因子 / 疾患感受性遺伝子 / 感受性遺伝子 … More Except Principal Investigator 慢性関節リウマチ / 軟骨 / 糖鎖抗原 / cbfal / CTGF / Rheumatoid Arthritis / cartilage / サイトカイン / 骨 / Rheumatoid arthritis / 関節破壊 / IL-6,-8 / 骨髄球系細胞 / 感作療法 / テロメラーゼ / テロメア / development / mutant animal / tooth / hone / ecogenin / パールカン / アクチン / 骨折治癒 / トランスジェニックマウス / 成長 / cbfa1 / 変異動物 / 歯 / エコジェニン / Matrix Metalloproteinase / Humanized Antibody / Monocronal Antibody / Cartilage / Synovium / SCID-HuRAg mouse / Apoptosis / 治療 / モノクローナル抗体 / SCIDマウス / T細胞 / リンパ球 / 破骨細胞 / 慢性間接リウマチ / マトリックスメタロプロテアーゼ / ヒト化抗体 / モノクロナール抗体 / 関節リウマチ / 滑膜 / SCID-HuRAgマウス / アポトーシス / Tissue repair / Joint destruction / Liposome / Sendai virus / Gene therapy / ヒト血小板由来増殖因子 / 修復靱帯 / 関節軟骨 / Hemagglutinating virus of Japan / 遺伝子導入 / リポゾーム / 滑膜細胞 / Hemagglutinating virus of Japan (HVJ) / おとり型核酸医薬(デコイ) / NFkB / Hemagglutinating virus of Japan(HVJ) / 創修復 / おとり型核酸医薬 / 転写因子 / 肝細胞増殖因子 / 組織修復 / リポソーム / センダイウイルス / 遺伝子治療 / Cytokine / Polymorphonuclear Cell / Nurse Cell / Stromal Cell / Myeloid Lineage Cell / Difucosylated Type 2 Chain / Bone Marrow / 悪性腫瘍 / 多型核白血球 / ナ-ス細胞 / 間葉系細胞 / 悪性腫瘍特異糖鎖膜抗原 / 骨髄 / Inhibitor / Citotoxity / Serum / Reumatoid arthritis / 細胞傷害性因子 / 組織傷害 / インヒビター / 細胞傷害 / 血清 / cytokines / differentiation / bone / periosteum / 分化 / 骨膜細胞 / Sensitization / Carbohydrate / Oncofetal membrane marker / 癌 / activated CD8(+) T cells / myeloid cells / epiphyseal bone marrow / iliac bone marrow / rheumatoid arthritis / ILー1 / 組織破壊活性 / MY4(+) / 特異な骨髄球系カスケ-ド / GMCSF / MY4抗原 / 重症病型 / 活性型T細胞 / 罹患関節部骨髄 / 腸骨骨髄 / Glycoprotein Derivative (TCA) / Di-fucosylated Type 2 Chain / Sensitization Therapy / Carbohydrate Structure / Oncofetal Markers / Myeloid Cell / RA Patient / 骨髄球系カスケ-ド / 悪性腫瘍特異抗原 / 皮内注射 / 糖鎖化合物 / 自己MLR / 骨髄球 / 癌特異抗原 / 糖鎖膜抗原 / 軟骨細胞 / 骨芽細胞 / 細胞寿命 / 細胞老化 / 再生医学 Less

軟骨表層細胞の分化誘導と異方性を有する軟骨再生Principal Investigator
- Principal Investigator
  
  木村友厚
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  University of Toyama
Analysis of zonal lineage of articular chondrocyte for cartilage regenerationPrincipal Investigator
- Principal Investigator
  
  KIMURA Tomoatsu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  University of Toyama
Development of therapeutic strategy targeting common pathway of cartilage degenerationPrincipal Investigator
- Principal Investigator
  
  KIMURA Tomoatsu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  University of Toyama
Strategic approach for cartilage degeneration based on functional analysis of susceptibility genePrincipal Investigator
- Principal Investigator
  
  TOMOATSU Kimura
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  University of Toyama
Regulation of mesenchymal cell differentiation and biological cartilage repair using cell supplementationPrincipal Investigator
- Principal Investigator
  
  KIMURA Tomoatsu
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  University of Toyama
Genes associated with cartilage differentiation and their application to cartilage repairPrincipal Investigator
- Principal Investigator
  
  KIMURA Tomoatsu
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
骨関節組織の老化変性の発生機序と、細胞寿命・老化の克服による関節再生修復法の開発
- Principal Investigator
  
  YUDOH Kazuo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Toyama Medical and Pharmaceutical University
Functional analysis of the cartilage-derived multifunctional growth factor ecogenin/CTGF by using mutant animals
- Principal Investigator
  
  TAKIGAWA Masaharu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
Regulation of cartilage destruction using tissue-specific expression systemPrincipal Investigator
- Principal Investigator
  
  KIMURA Tomoatsu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Novel humanized anti-Fas Mab provide a new treatment for Rheumatoid Arthiritis
- Principal Investigator
  
  MATSUNO Hiroaki
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Establishment of in vivo direct gene transfer system into joint using HVJ-liposome
- Principal Investigator
  
  OCHI Takahiro
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
Abnormality of Cartilage development by gene defectsin cartilage collagensPrincipal Investigator
- Principal Investigator
  
  HAYASHIDA Kenji, 木村友厚
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
Abnormal Myeloid Lineage Cells Expressing the Difucosyl or Trifucosyl Type 2 Chain in Bone Marrow Cells of Patinets with Severe Rheumatoid Arthritis.
- Principal Investigator
  
  OCHI Takahiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
Development of Intradermal Sensitization Therapy to Ra Patients Using Oncofetal Carbohydrate Membrane Structure
- Principal Investigator
  
  OCHI Takahiro
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
癌細胞特異糖鎖抗原による慢性関節リウマチ患者に対する感作療法
- Principal Investigator
  
  OCHI Takahiro
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
Elucidation of genetic disorders in skeletal dysplasias.
- Principal Investigator
  
  NAKAHARA Haruhiko
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
Serum Cytotoxic Factor and its' Inhibitorin Rheumatoid Arthritis.
- Principal Investigator
  
  OCHI Takahiro, 東文造
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
Analysis of chondrodysplasias using transgenic mouse model.Principal Investigator
- Principal Investigator
  
  KIMURA Tomoatsu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
Myeloid cell cascade bearing onco-fetal membrane structure found in the involved epiphyseal bone marrow in patients with severe active rheumatoid arthritis
- Principal Investigator
  
  OCHI Takahiro
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
軟骨形成異常疾患の病因の解明ーコラ-ゲン遺伝子異常の解析ーPrincipal Investigator
- Principal Investigator
  
  木村友厚
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University

All 2018 2016 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] リウマチ性疾患. 「NEWエッセンシャル整形外科学」2012
- Author(s)
  木村友厚
- Total Pages
  578
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-24390350
[Journal Article] A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell.2018
- Author(s)
  Hashiramoto A, Konishi Y, Murayama K, Kawasaki H, Yoshida K, Tsumiyama K, Tanaka K, Mizuhara M, Shiotsuki T, Kitamura H, Komai K, Kimura T, Yagita H, Shiozawa K, Shiozawa S.
- Journal Title
  
  J Biol Chem
  
  Volume: 293 Issue: 6 Pages: 1933-43
- DOI
  10.1074/jbc.m117.798884
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08408, KAKENHI-PROJECT-18K09099
[Journal Article] A selective c-Fos/AP-1 inhibitor prevents cartilage destruction and subsequent osteophyte formation2018
- Author(s)
  Motomura Hiraku、Seki Shoji、Shiozawa Shunichi、Aikawa Yukihiko、Nogami Makiko、Kimura Tomoatsu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 497 Issue: 2 Pages: 756-761
- DOI
  10.1016/j.bbrc.2018.02.147
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10895, KAKENHI-PROJECT-16K10816, KAKENHI-PROJECT-18K09099
[Journal Article] Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.2016
- Author(s)
  Yahara Y, Takemori H, Okada M, Kosai A, Yamashita A, Kobayashi T, Fujita K, Itoh Y, Nakamura M, Fuchino H, Kawahara N, Fukui N, Watanabe A, Kimura T, Tsumaki N.
- Journal Title
  
  Nat Commun
  
  Volume: 7 Issue: 1 Pages: 10959-10959
- DOI
  10.1038/ncomms10959
- NAID
  120005741112
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861716, KAKENHI-PROJECT-15H02561, KAKENHI-PROJECT-15K15546
[Journal Article] A human amnion-derived extracellular matrix-coated cell-free scaffold for cartilage repair: in vitro and in vivo studies.2016
- Author(s)
  Nogami M, Kimura T, et al.
- Journal Title
  
  Tissue Engineering
  
  Volume: 22 Issue: 7-8 Pages: 680-688
- DOI
  10.1089/ten.tea.2015.0285
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15546, KAKENHI-PROJECT-15H04980, KAKENHI-PROJECT-16K10816, KAKENHI-PROJECT-16K10895, KAKENHI-PROJECT-16K08905
[Journal Article] Inhibitory effect of tacrolimus on progression of joint damage in patients with rheumatoid arthritis.2014
- Author(s)
  Motomura H, Matsushita I, Seki E, Mine H, Kimura T.
- Journal Title
  
  Int J Rheum Dis
  
  Volume: 17 Pages: 749-754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390350
[Journal Article] Cartilage intermediate layer protein promotes lumbar disc degeneration．2014
- Author(s)
  Seki S, Tsumaki N, Motomura H, Nogami M, Kawaguchi Y, Hori, T Suzuki K, Yahara Y, Higashimoto M, Oya T, Ikegawa S, Kimura T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 446 Issue: 4 Pages: 876-881
- DOI
  10.1016/j.bbrc.2014.03.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390350, KAKENHI-PROJECT-24390354, KAKENHI-PROJECT-25462289
[Journal Article] Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant.2013
- Author(s)
  You-Qiang Song, Tatsuki Karasugi, Kenneth M.C. Cheung, Kazuhiro Chiba, Daniel W.H. Ho, Atsushi Miyake, Patrick Y.P. Kao, Kit Ling Sze, Anita Yee, Atsushi Takahashi, Yoshiharu Kawaguchi, Yasuo Mikami, Morio Matsumoto, Daisuke Togawa, Masahiro Kanayama, Dongquan Shi, Jin Dai, Qing Jiang, Tomoatsu Kimura, et al.
- Journal Title
  
  J Clin Invest.
  
  Volume: 123 Pages: 4909-4917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390350
[Journal Article] Anatomic mapping of short external rotators shows the limit of their preservation during total hip arthroplasty.2012
- Author(s)
  Yoshiaki Ito, Isao Matsushita, Tomoatsu Kimura
- Journal Title
  
  Clin. Orthop. Relat. Res.
  
  Volume: 470 Issue: 6 Pages: 1690-1695
- DOI
  10.1007/s11999-012-2266-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390350
[Journal Article] Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells.2012
- Author(s)
  Kayo Suzuki, Yoshito Matsui mail, Mami Higashimoto, Yoshiharu Kawaguchi, Shoji Seki, Hiraku Motomura, Takeshi Hori, Yasuhito Yahara, Masahiko Kanamori, Tomoatsu Kimura
- Journal Title
  
  PLoS One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390350
[Journal Article] Isolation and characterization of human amniotic mesenchymal stem cells and their chondrogenic differentiation2012
- Author(s)
  Nogami M., Tsuno H., Koike C., Okabe M.,Yoshida T., Seki S., Matsui Y., Kimura T.,Nikaido T
- Journal Title
  
  Transplantation
  
  Volume: 93(12) Issue: 12 Pages: 1221-8
- DOI
  10.1097/tp.0b013e3182529b76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590498, KAKENHI-PROJECT-22791365, KAKENHI-PROJECT-24390350
[Journal Article] Myxoid liposarcoma with EWS-CHOP type I fusion gene2010
- Author(s)
  Suzuki K, Matsui Y, Endo K, Kubo T, Hasegawa T, Kimura T, Ohtani O, Yasui N.
- Journal Title
  
  Anticancer Res
  
  Volume: 30 Pages: 4679-4683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] Differential expression of Tenomodulin and Chondromodulin-1 at the insertion site of the tendon reflects a phenotypic transition of the resident cells2010
- Author(s)
  Yukata K, Matsui Y, Shukunami C, Takimoto A, Hirohashi N, Ohtani O, Kimura, T. Hiraki Y, Yasui N.
- Journal Title
  
  Tissue Cell
  
  Volume: 42 Pages: 116-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] Specificity of fusion genes in adipocytic tumors2010
- Author(s)
  Kubo T, Matsui Y, Naka N, Araki N, Myoui A, Endo K, Yasui N, Ohtani O, Suzuki K, Kimura T, Yoshikawa H, Ueda T.
- Journal Title
  
  Anticancer Res
  
  Volume: 30 Pages: 661-664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)-induced apoptosis through up-regulations of death receptor 4(DR4) and death receptor 5(DR5) in human osteosarcoma cells2010
- Author(s)
  Hori T, Kondo T, Kanamori M, Tabuchi Y, Ogawa R, Zhao QL, Ahmed K, Yasuda T, Seki S, Suzuki K, Kimura T.
- Journal Title
  
  J Orthop Res
  
  Volume: 28 Pages: 739-745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)-induced apoptosis through up-regulation of death receptor 5(DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells2010
- Author(s)
  Hori T, Kondo T, Kanamori M, Tabuchi Y, Ogawa R, Zhao QL, Ahmed K, Yasuda T, Seki S, Suzuki K, Kimura T.
- Journal Title
  
  Cancer Lett
  
  Volume: 287 Pages: 98-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] Establishment of a new human osteosarcoma cell line, UTOS-1 : cytogenetic characterization by array comparative genomic hybridization2009
- Author(s)
  Yasuda T, Kanamori M, Nogami S, Hori T, Oya T, Suzuki K, Kimura T.
- Journal Title
  
  J Exp Clin Cancer Res
  
  Volume: 28 Pages: 26-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] Radiographic progression in weight-bearing joints of patients with rheumatoid arthritis after TNF-blocking therapies2009
- Author(s)
  Seki E, Matsushita I, Sugiyama E, Taki H, Shinoda K, Honoki H, Motomura H, Kimura T.
- Journal Title
  
  Clin Rheumatol
  
  Volume: 28 Pages: 453-460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] Association of the tag SNPs in the human SKT gene(KIAA1217) with lumbar disc herniation2009
- Author(s)
  Karasugi T, Semba K, Hirose Y, Kawaguchi Y, Kimura T, Ikageka S, et al.
- Journal Title
  
  J Bone Miner Res
  
  Volume: 24 Pages: 1537-1543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] Effect of small interference RNA(siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model2009
- Author(s)
  Seki S, Asanuma-Abe Y, Masuda K, Kawaguchi Y, Asanuma K, Muehleman C, Iwai A, Kimura T.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] Molecular mechanism of apoptosis and gene expressions in human lymphoma U937 cells treated with anisomycin.2008
- Author(s)
  Hori T, Kondo T, Tabuchi Y, Takasaki I, Zhao Q, Kanamori M, Yasuda T, Kimura T
- Journal Title
  
  Chem -Biol Interac 172
  
  Pages: 125-140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390415
[Journal Article] Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells2008
- Author(s)
  Nakamura C, Matsushita I, Kosaka E, Kondo T, Kimura T.
- Journal Title
  
  Rheumatology
  
  Volume: 47 Pages: 418-424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] PDGF receptor β is a potent regulator of mesenchymal stromal cell function.2008
- Author(s)
  Tokunaga A, Oya T, Ishii Y, Motomura H, Nakamura C, Ishizawa S, Fujimori T, Nabeshima Y, Umezawa A, Kanamori M, Kimura T, Sasahara M
- Journal Title
  
  J Bone Miner Res 23
  
  Pages: 1519-1528
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390415
[Journal Article] Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and lowintensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells.2008
- Author(s)
  Nakamura C, Matsushita I, Kosaka E, Kondo T, Kimura T
- Journal Title
  
  Rheumatology 47
  
  Pages: 418-424
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390415
[Journal Article] A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation2008
- Author(s)
  Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S.
- Journal Title
  
  Am J Hum Genet
  
  Volume: 82 Pages: 1122-1129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] PDGF receptorβis a potent regulator of mesenchymal stromal cell function2008
- Author(s)
  Tokunaga A, Oya T, Ishii Y, Motomura H, Nakamura C, Ishizawa S, Fujimori T, Nabeshima Y, Umezawa A, Kanamori M, Kimura T, Sasahara M.
- Journal Title
  
  J Bone Miner Res
  
  Volume: 23 Pages: 1519-1528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] Molecular mechanism of apoptosis and gene expressions in human lymphoma U937 cells treated with anisomycin2008
- Author(s)
  Hori T, Kondo T, Tabuchi Y, Takasaki I, Zhao Q, Kanamori M, Yasuda T, Kimura T.
- Journal Title
  
  Chem Biol Int
  
  Volume: 172 Pages: 125-140
- Data Source
  KAKENHI-PROJECT-20390395
[Journal Article] Splicing factor 3b subunit 4 binds BMPR-IA and inhibits osteochondral cell differentiation.2007
- Author(s)
  Watanabe H, Shionyu M, Kimura T, Kimata K, Watanabe H
- Journal Title
  
  J Biol Chem 28
  
  Pages: 20728-20738
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390415
[Journal Article] Gas6, a new regulator of chondrogenic differentiation from mesenchymal cells.2007
- Author(s)
  Motomura H, Niimi H, Sugimori K, Ohtsuka T, Kimura T, Kitajima I
- Journal Title
  
  Biochem Biophys Res Commun 357
  
  Pages: 997-1003
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390415
[Journal Article] Association study of COL9A2 with lumbar disc disease in the Japanese population.2006
- Author(s)
  Seki S, Kawaguchi Y, Mori M, Mio F, Chiba K, Mikami Y, Tsunoda T, Kubo T, Toyama Y, Kimura T, Ikegawa S
- Journal Title
  
  J Hum Genet 51
  
  Pages: 1063-1067
- NAID
  10018641536
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390415
[Presentation] 骨代謝と軟骨代謝の接点. SIK3をターゲットとした変形性関節症の治療2016
- Author(s)
  箭原康人, 竹森洋, 岡田稔, 高才東, 山下晃弘, 小林与人, 藤田香里, 伊東裕美, 中村正裕, 渕野裕之, 川原信夫, 福井尚志, 渡辺亮, 木村友厚, 妻木範行
- Organizer
  第34回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K15546
[Presentation] 軟骨細胞特異的なSik3の欠失は関節軟骨の厚みを増大させる2016
- Author(s)
  箭原康人, 竹森洋, 岡田稔, 高才東, 山下晃弘, 小林与人, 藤田香里, 伊東裕美, 中村正裕, 渕野裕之, 川原信夫, 福井尚志, 渡辺亮, 木村友厚, 妻木範行
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K15546
[Presentation] SIK経路阻害剤は変形性関節症の進行を抑制する2016
- Author(s)
  箭原康人、竹森洋、木村友厚、妻木範行
- Organizer
  第29回日本軟骨代謝学会
- Place of Presentation
  広島
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-15K15546
[Presentation] 変形性関節症治療のupdate2013
- Author(s)
  木村友厚
- Organizer
  第57回日本リウマチ学会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Data Source
  KAKENHI-PROJECT-24390350
[Presentation] ラット椎間板変形性関節症の病態と治療 -ターゲットは痛みか骨か軟骨か-2013
- Author(s)
  木村友厚
- Organizer
  第41回日本関節病学会
- Place of Presentation
  愛知県産業労働センターウインクあいち（愛知県名古屋市）
- Data Source
  KAKENHI-PROJECT-24390350
[Presentation] c-FOS/AP-1阻害は変形性関節症モデルの軟骨破壊を抑制する2011
- Author(s)
  元村拓、松井好人、関庄二、塩沢俊一、木村友厚
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  前橋
- Data Source
  KAKENHI-PROJECT-20390395
[Presentation] Polymorphisms in genes encoding extracellular matrix proteins are associated with susceptibility to lumbar disc herniation2010
- Author(s)
  K, Mio F, Hirose Y, Kawaguchi Y, Mikami Y, Kimura T, Kubo T, Toyama Y, Ikegawa S.
- Organizer
  ISSLS Annual Meeting
- Place of Presentation
  Newzeland
- Data Source
  KAKENHI-PROJECT-20390395
[Presentation] Small interference RNA(siRNA) of ADAMTS4 and ADAMTS5 in nucleus pulposus cells in vitro and effects of ADAMTS5 siRNA in the rabbit anular needle puncture model2010
- Author(s)
  Seki S, Abe Y, Kawaguchi Y, Asanuma K, Masuda K, Kimura T.
- Organizer
  37^<th> Annual Meeting International Society for the Study of the Lumbar Spine
- Place of Presentation
  AucklandChiba
- Data Source
  KAKENHI-PROJECT-20390395
[Presentation] Czech dysplasia occurring in a Japanese Family2010
- Author(s)
  Matsui Y, Michigami T, Kawabata H, Kimura T, Ohtani O, Nishimura G.
- Organizer
  第83回日本整形外科学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390395
[Presentation] CILP, cartilage intermediate layer protein, promotes lumbar disc degeneration2010
- Author(s)
  Seki S, Tsumaki N, Kawaguchi Y, Abe Y, Suzuki K, Iwai A, Oya T, Ikegawa S, Kimura T.
- Organizer
  56^<th> Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-20390395
[Presentation] Small interference RNA(siRNA) of ADAMTS4 and ADAMTS5 in NP cells in vitro and effect of ADAMTS5 siRNA in the rabbit anular needle puncture model2009
- Author(s)
  Seki S, Abe Y, Kawaguchi Y, Asanuma K, Masuda K, Kimura T.
- Organizer
  36rd Annual Meeting of the International Society for the Study of the Lumber Spine
- Place of Presentation
  Miami
- Data Source
  KAKENHI-PROJECT-20390395
[Presentation] Osteoarthritis and cartilage degeneration : Where are we?2009
- Author(s)
  Kimura T.
- Organizer
  First Indonesia Japan Rheumatology Forum
- Place of Presentation
  Bali
- Data Source
  KAKENHI-PROJECT-20390395
[Presentation] A functional polymorphism in COL11A1 is associated with susceptibility to lumbar disc herniation2009
- Author(s)
  Mio F, Chiba K, Kawaguchi Y, Mikami Y, Seki S, Mori M, Hirose Y, Kubo T, Kimura T, Toyama Y, Ikegawa S.
- Organizer
  5^<th> Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  Las Vegas
- Data Source
  KAKENHI-PROJECT-20390395
[Presentation] 骨関節と細胞外マトリックス2009
- Author(s)
  木村友厚
- Organizer
  第114回日本解剖学会総会全国学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20390395
[Presentation] Splicing factor 3b subunit 4 binds BMPR-IA and inhibits osteochondral cell differentiation.2007
- Author(s)
  Watanabe H, Shionyu M, Kimura T, Kimata K, Watanabe H
- Organizer
  53rd Annual Meeting of ORS
- Place of Presentation
  San Diego.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390415
[Presentation] Ultra sound-induced enhancement of histone deacetylase inhibition on rheumatoid synovial cells.2007
- Author(s)
  Nakamura C, Matsusita I, Kosaka E, Kondoh T, Kimura T
- Organizer
  53rd Annual Meeting of ORS
- Place of Presentation
  San Diego.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390415
[Presentation] Gas6, a new regulator of chondrogenic differentiation in mesenchymal cells.2007
- Author(s)
  Motomura H, Niimi H, Sugimori K, Ohtsuka T, Kimura T, Kitajima I
- Organizer
  53rd Annual Meeting of ORS
- Place of Presentation
  San Diego.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390415
[Presentation] BMP2 activates PI3K/Akt-NF-kappaB signal transduction pathway in chondrogenesis.2006
- Author(s)
  Sugimori K, Motomura H, Matsui K, Kitajima I, Kimura T
- Organizer
  52nd Annual Meeting of ORS
- Place of Presentation
  Chicago.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390415
[Presentation] The prominent form of splice variants of vascular endotherial growth factor, VEGF121, was upregulated by interleukin-1β in human intervertebral disc cells.2006
- Author(s)
  Abe Y, Pichika R, Aoki Y, An HS, Muehleman C, Kimura T, Masuda K
- Organizer
  52nd Annual Meeting of ORS
- Place of Presentation
  Chicago.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390415
[Presentation] Cell-based therapy for articular cartilage repair.2005
- Author(s)
  Kimura T
- Organizer
  6th Pan Pacific Connective Tissue Societies Symposium
- Place of Presentation
  Hawaii.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390415
[Presentation] Lumbar disc degeneration progression in young adults in their 20’s.
- Author(s)
  4) Makino H, Kawaguchi Y, Nakano M, Yasuda T, Seki S, Suzuki K, Kimura T.
- Organizer
  41st Annual Meeting of the International Society for the Study of the Lumbar Spine
- Place of Presentation
  Seoul
- Year and Date
  2014-06-03 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-24390350
[Presentation] Effect of a selective inhibitor of c-Fos/activator protein-1 on intervertebral disc degeneration induced by needle puncture in rats.
- Author(s)
  Makino H, Seki S, Motomura H, Yahara Y, Nogami M, Shiozawa S, Kimura T.
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  Las Vegas
- Year and Date
  2015-03-28 – 2015-03-30
- Data Source
  KAKENHI-PROJECT-24390350

1. OCHI Takahiro (80112035)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. ONO Keiro (70028330)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. YUDOH Kazuo (60272928)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. MATSUNO Hiroaki (00219461)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. SEKI Shoji (00432112)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
6. OWAKI Hajime (60223872)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. KAWAGUCHI Yoshiharu (00262527)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
8. HAYASHIDA Kenji (50273686)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. WAKITANI Shigeyuki (70243243)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 野上真紀子 (30750202)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. NAKAHARA Haruhiko (10198179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YASUI Natsuo (00157984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SHIMAOKA Yasunori (00260638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TOMITA Tetsuya (30283766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KANEDA Yasufumi (10177537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YONEHARA Shin (00124503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKIGAWA Masaharu (20112063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. NAKANISHI Tohru (30243463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KUBOTA Satoshi (90221936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YAMAAI Tomoichirou (00158057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KOMORI Toshifumi (00252677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. MORITA Yuji (30313604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MATSUSHITA Isao (80345587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. GEJO Ryu-ichi (00359712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 長田龍介 (40293310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 東文造 (50231915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. HASHIRAMOTO Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. YAMASHITA Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. OKABE Motonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. KOIKE Cika

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 吉田淑子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 二階堂敏雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kimura Tomoatsu 木村 友厚

木村 友厚 キムラ トモアツ

KIMURA Tomoatsu 木村 友厚

TOMOATSU Kimura 木村 友厚

KIMURA Tomoatu 木村 友厚

Research Projects

Research Products

Co-Researchers

軟骨表層細胞の分化誘導と異方性を有する軟骨再生Principal Investigator

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Analysis of zonal lineage of articular chondrocyte for cartilage regenerationPrincipal Investigator

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Development of therapeutic strategy targeting common pathway of cartilage degenerationPrincipal Investigator

Principal Investigator

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Strategic approach for cartilage degeneration based on functional analysis of susceptibility genePrincipal Investigator

Principal Investigator

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Regulation of mesenchymal cell differentiation and biological cartilage repair using cell supplementationPrincipal Investigator

Principal Investigator

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Genes associated with cartilage differentiation and their application to cartilage repairPrincipal Investigator

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Principal Investigator

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Principal Investigator

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Regulation of cartilage destruction using tissue-specific expression systemPrincipal Investigator

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Principal Investigator

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Abnormality of Cartilage development by gene defectsin cartilage collagensPrincipal Investigator

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Principal Investigator

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Kimura Tomoatsu 木村友厚

木村友厚キムラトモアツ

KIMURA Tomoatsu 木村友厚

TOMOATSU Kimura 木村友厚

KIMURA Tomoatu 木村友厚