SHIRAI Ryuichi 白井隆一

… Alternative Names

SIRAI Ryuiti

白井隆一

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Researcher Number	80183838
Other IDs
External Links
Affiliation (Current)	2025: 同志社女子大学, 薬学部, 特任教授
Affiliation (based on the past Project Information) *help	2006 – 2008: 同志社女子大学, 薬学部, 教授 1999 – 2004: 奈良先端科学技術大学院大学, 物質科学教育研究センター, 助教授 1999: 奈良先端大学, 大学院・物質科学教育研究センター, 助教授 1993 – 1998: 東京大学, 分子細胞生物学研究所, 助手 1993: 東大, 分子細胞生物学研究所, 助手 1990: Kitasato Univ., Pharm. Sci., Assistant 1988: 北里大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Chemical pharmacy / Chemical pharmacy / 医薬分子機能学 Except Principal Investigator Chemical pharmacy / 医薬分子機能学
Keywords	Principal Investigator 全合成 / 不斉合成 / チューブリン / CJP2 / stereoselective synthesis / total synthesis / asymmetric synthesis / PI 3,5-P2 / 立体選択的合成 / cdc25A … More / dysidiolide / 微小管 / キュラシンA / 構造活性相関 / 有糸分裂阻害剤 / ceramide / inositol / sialic acid / ganglioside / セラミド / イノシトール / シアル酸 / ガングリオシド / glucose / intracellular signal transduction / second messenger / phosphatidylinositol / PI3, 5-P2 / グルコース / 細胞内情報伝達 / セカンドメッセンジャー / フォスファチジルイノシトール / PI3,5-P2 / structure-activity relationship / Diels-Alder reaction / asymmetric totalsynthesis / cell cycle / dual phosphatase / sesterterpene / セスタテルペン / Diels-Alder反応 / 不斉全合成 / 細胞周期 / dualフォスファターゼ / セスタテルjペン / TOTAL SYNTHESIS / ASYMMETRIC SYNTHESIS / ANTIMITOTIC AGENT / MICROTUBULES / TUBULIN / USTILOXIN / CURACIN / ウスチロキシンD / ウスチロキシン / キュラシン / 1,3-ジオール / 1,2-ジオール / 不斉非対称化 / ピペラジン / プロテアソーム / Salinosporamide A / チアゾリン / シクロプロパン / 有毛分裂阻害剤 / 稲こうじ / 環状ペプチド / 酸化白金 / ウスチロキシンA / フォモプシンA / 光環化反応 / 分子認識 / インターカレーター / DNA / アントラキノン / ダイネミシン … More Except Principal Investigator 分子設計 / 分子認識 / チューブリン / KDN / molecular design / thalidomide / 医薬品化学 / サリドマイド / フタルイミド / レチノイド / tubulin / キュラシンA / 有糸分裂阻害剤 / ウスチロキシン / 情報伝達 / 微小管機能制御物質 / Koenigs-Knorr / stereochemistry / glycosylation / N-acetylneuraminic acid / 立体化学 / X線解析 / 3-デオキシ-D-ノヌロン酸 / 1,7-ラクトン誘導体 / N-アセチル-2,3-デヒドロ-2-デオキシノイラミン酸 / N-アセチルノイラミン酸 / 神経細胞増生 / 立体配置 / Neu5Ac / N__ーーアセチルノイラミン酸 / 神経突起伸展 / グリコシド / G_<M3>アナログ / マイトマイシン / シアル酸 / Nーアセチルノイラミン酸 / Bidentate Achiral Amine / Tetradentate Chiral Amine / Catalytic Asymmetric Protonation / Catalytic Asymmetric Alkylation / Catalytic Asymmetric Deprotonation / 反応加速 / 配位子交換 / リチウムエノラート / 含フッ素不斉四級炭素 / 不斉四級炭素 / 不斉三級炭素 / 不斉アシル化 / 不斉アルキル化 / リチウムエイラート / 二座配位子型アキラルアミン / 四座配位子型キラルアミン / 触媒的不斉プロトン化 / 触媒的不斉アルキル化 / 触媒的不斉脱プロトン化 / ligand / enzyme inhibitors / structural development / androgen / retioids / nuclear receptor / 情報伝達物質 / 阻害剤 / シナージスト / ホモフタルイミド / アンタゴニスト / アンドロジェン / ヘシン / 構造活性相関 / リガンド / 酵素阻害剤 / 構造展開 / アンドロゲン / 核内レセプター / phosphatidylinositol 3-phosphate / FAB MS / matrix / phosphatidylinositol 3-kinase / phosphatidylinositol / 質量分析 / PI3 5-ホスファターゼ / PI3キナーゼ / 脂肪酸側鎖 / ホスファチジルイノシトール 3-リン酸 / 負イオンFABMS / ホスファチジルイノシトール 3-キナーゼ / ホスファチジルイノシトール3-リン酸 / マトリックス / 負イオンFAB MS / ホスファチジルイノシトール3-キナーゼ / ホスファチジルイノシトール / arenastatin A / curacin A / ustiloxins / action mechanism / antimitotic agent / アレナスタチンA / 作用機作 / biological response modifier / enantio-dependence / bidirectional regulation / cell type / cytokine / phthalimide / tumor necrosis factor / 生物応答調節剤 / 光学異性体 / 2方向性調節 / 光学活性依存性 / 生物学的応答調節剤 / 細胞種 / サイトカイン / 腫瘍壊死因子 / tumor promoter / receptor / nucleic acid / affinity labeling / porphyrin / retinoid / intercalator / dextran / ヘミン / 水溶性ポリマー / 塩基選択性 / ジヌクレオチド / インターカレーション / 発癌プロモーター / 受容体 / 核酸 / アフィニティーラベル / ポルフィリン / インターカレーター / デキストラン / curacin / aza-combretastatin / ustiloxin / molecular recognition / microtubules / フォモプシン / リゾキシン / 分子確認 / キュラシン / アザコンプレタスタチン / 分子機能 / 微小管機能 / 転移 / 発癌 / 細胞応答 / Gタンパク質 / キナーゼ / がん / ホスホリパーゼ / MAPキナーゼ / イノシトールリン脂質 / アダプター / 分化 / 組織応答 / ホシファテシジルイノシトールキナーゼ / リン脂質 / 新規抗がん剤 / アザコンブレタスタチン Less

Total synthesis of Salinosporamide A, a potent proteasome inhibitorPrincipal Investigator
- Principal Investigator
  
  SHIRAI Ryuichi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Doshisha Women's College of Liberal Arts
Synthetic study of novel inositol phosphoceramide CJP2Principal Investigator
- Principal Investigator
  
  SHIRAI Ryuichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
Total synthesis of phosphatidylinositol 3,5-bisphosphatePrincipal Investigator
- Principal Investigator
  
  SHIRAI Ryuichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
Catalytic Asymmetric Alkylation and Protonation of Lithium Enolates
- Principal Investigator
  
  KOGA Kenji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Nara Institute of Science and Technology
がんの発生、発達に関する情報伝達の解析
- Principal Investigator
  
  福井泰久
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Structural development of bio-active compounds affecting nuclear receptor function
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
Asymmetric synthesis of proteinphosphatase inhibitor dysidiolode and its potent analogsPrincipal Investigator
- Principal Investigator
  
  SHIRAI Ryuichi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
  The University of Tokyo
Mass spectrometry of phosphatidylinositols with various fatty acid side chain
- Principal Investigator
  
  MORISAKI Naoko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The Universityu of Tokyo
STUDIES ON THE ANTIMITOTIC AGENTS-TUBULIN INTERACTION AND DRUG DESIGN
- Principal Investigator
  
  IWASAKI Shigeo
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES,THE UNIVERSITY OF TOKYO
SYNTHESIS OF ANTIMITOTIC NATURAL PRODUCTSPrincipal Investigator
- Principal Investigator
  
  SHIRAI Ryuichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  UNIVERSITY OF TOKYO
有糸分裂阻害剤キュラシンAの不斉全合成Principal Investigator
- Principal Investigator
  
  白井隆一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
Development of Phthalimide-type Novel Tumor Necrosis Factor (TNF) Production-regulators
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  THE UNIVERSITY OF TOKYO
フォモプシン、ウスチロキシンをリ-ド化合物とする新規有糸分裂阻害剤の設計と合成Principal Investigator
- Principal Investigator
  
  白井隆一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
Preparation of Functional Polylipid Biofactors
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  THE UNIVERSITY OF TOKYO
リガンド分子設計によるチューブリンの薬物認識機構の解析
- Principal Investigator
  
  IWASAKI Shigeo
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
ダイネミシン型アミノアントラキノン類の合成およびDNAとの相互作用の研究Principal Investigator
- Principal Investigator
  
  白井隆一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
Regulators of Microtubule Assembly : Molecular Recognition Mechanism and Developement of New Regulators.
- Principal Investigator
  
  IWASAKI Shigeo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Institute of Molecular and Cellular Biosciences The University of Tokyo
Stereochemical Studies on Sialic Acid Derivatives
- Principal Investigator
  
  OGURA Haruo
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University

All 2009 2008 2007

All Journal Article Presentation

[Journal Article] Palladium-Catalyzed 1,2-Addition of Potassium Aryl- and Alkenyltrifluoro borates to Aldehydes using Thioether-Imidazolinium Carbene Ligands2008
- Author(s)
  Masami Kuriyama, Rumiko Shimazawa, Terumichi Enomoto, Ryuichi Shirai
- Journal Title
  
  Journal of Organic Chemistry 73
  
  Pages: 6939-6942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590023
[Journal Article] Direct asymmetric aldol reactions catalyzed by lproline-2,4,6-trinitroanilide2008
- Author(s)
  Kosuke Sato, Masami Kuriyama, Rumiko Shimazawa, Tsumoru Morimoto, Kiyomi Kakiuchi, Ryuichi Shirai
- Journal Title
  
  Tetrahedron Letters 49
  
  Pages: 2402-2406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590023
[Journal Article] Anacid-catalyzed ring-switch reaction of lactums to lactones : concise synthesis of 2,4-dialkyl-3-hydroxybutanolides2008
- Author(s)
  Chiaki Yamauchi, Masami Kuriyama, Rumiko Shimazawa, Tsumoru Morimoto, Kiyomi Kakiuchi, Ryuichi Shirai
- Journal Title
  
  Tetrahedron 64
  
  Pages: 3133-3140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590023
[Journal Article] Design and Synthesis of Novel C2-Symmetric Chiral Piperadines and an Application to Asymmetric Acylation of σ-Symmetric 1,2-Diols2008
- Author(s)
  Daisuke Nakamura, Kiyomi Kakiuchi, Kenji Koga, Ryuichi Shirai
- Journal Title
  
  Organic Letters 8
  
  Pages: 6139-6142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590023
[Journal Article] Efficient 1,2-Addition of Aryl- and Alkenylboronic Acids to Aldehydes Catalyzed by the Palladium/Thioether-Imidazolinium Chloride System2008
- Author(s)
  Masami Kuriyama, Rumiko Shimazawa, Ryuichi Shirai
- Journal Title
  
  Journal of Organic Chemistry 73
  
  Pages: 1597-1600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590023
[Presentation] C-S二座配位子-パラジウム触媒による有機ホウ酸試薬のキラルアルデヒドへのジアステレオ選択的1,2-付加反応2009
- Author(s)
  榎本光伯, 栗山正巳, 白井隆一
- Organizer
  日本薬学会129年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-18590023
[Presentation] C-S二座配位子-パラジウム触媒による有機ホウ酸試薬のキラルアルデヒドへのジアステレオ選択的1,2-付加反応2008
- Author(s)
  榎本光伯, 栗山正巳, 白井隆一
- Organizer
  第58回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸薬科大学
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-18590023
[Presentation] 複素環カルベンを基盤とするC-S二座配位子-パラジウム触媒による有機ホウ素試薬を用いたアルデヒドへの付加反応2008
- Author(s)
  栗山正巳, 嶋澤るみ子, 白井隆一
- Organizer
  日本薬学会128年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-18590023
[Presentation] C-S二座配位子-パラジウム触媒を用いた有機三フッ化ホウ素塩のアルデヒドへの付加反応2008
- Author(s)
  栗山正巳, 嶋澤るみ子, 榎本光伯, 白井隆一
- Place of Presentation
  神戸薬科大学
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-18590023
[Presentation] C-S二座配位子-パラジウム触媒を用いた有機三フッ化ホウ素塩のアルデヒドへの付加反応2008
- Author(s)
  栗山正巳, 石山夏希, 榎本光伯, 嶋澤るみ子, 白井隆一, 尾野村治
- Organizer
  反応と合成の進歩シンポジウム
- Place of Presentation
  京都テルサ
- Year and Date
  2008-11-04
- Data Source
  KAKENHI-PROJECT-18590023
[Presentation] 複素環カルベンを基盤とするC-S二座配位子-パラジウム触媒による有機ホウ素試薬を用いたアルデヒドへの付加反応2007
- Author(s)
  栗山正巳, 嶋澤るみ子, 白井隆一
- Organizer
  第57回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-18590023

1. IWASAKI Shigeo (00013326)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. HASHIMOTO Yuichi (90164798)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MORISAKI Naoko (00092354)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. SHIMAZAWA Rumiko (00411083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. KURIYAMA Masami (40411087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
6. KOBAYASHI Hisayoshi (80225531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KOISO Yuikiko (50092200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KOGA Kenji (10012600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OGURA Haruo (90050335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMASAKI Toshiko (60230380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAI Toshitugu (30224322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FURUHATA Kimio (60050605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKAYANAGI Hiroaki (00050477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAKEDA Kazuyoshi (10050684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 福井泰久 (00181248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 黒崎知博 (50178125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 稲垣昌樹 (30183007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 一條秀憲 (00242206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 田村真理 (20124604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIRAI Ryuichi 白井 隆一

SIRAI Ryuiti

白井 隆一

Research Projects

Research Products

Co-Researchers

Total synthesis of Salinosporamide A, a potent proteasome inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

Synthetic study of novel inositol phosphoceramide CJP2Principal Investigator

Principal Investigator

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Total synthesis of phosphatidylinositol 3,5-bisphosphatePrincipal Investigator

Principal Investigator

Project Period (FY)

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Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Principal Investigator

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Principal Investigator

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Asymmetric synthesis of proteinphosphatase inhibitor dysidiolode and its potent analogsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

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SYNTHESIS OF ANTIMITOTIC NATURAL PRODUCTSPrincipal Investigator

Principal Investigator

Project Period (FY)

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有糸分裂阻害剤キュラシンAの不斉全合成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

フォモプシン、ウスチロキシンをリ-ド化合物とする新規有糸分裂阻害剤の設計と合成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

SHIRAI Ryuichi 白井隆一

白井隆一