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SAITO Hidetsugu  齋藤 英胤

ORCIDConnect your ORCID iD *help
… Alternative Names

齋藤 英胤  サイトウ ヒデツグ

斎藤 英胤  サイトウ ヒデツグ

SAITO hidetsugu  齋藤 英胤

SAITO Hidekazu  斎藤 英胤

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Researcher Number 80186949
Other IDs
Affiliation (based on the past Project Information) *help 2016 – 2017: 慶應義塾大学, 薬学部(芝共立), 教授
2012 – 2015: 慶應義塾大学, 薬学部, 教授
2008: Keio University, 医学部, 准教授
2007: Keio University, 医学部, 講師
2004: Keio University, Department of Medicine, Assistant Professor, 医学部, 講師 … More
2003: 慶應義塾大学, 医学部, 専任講師
2001 – 2002: 慶應義塾大学, 医学部, 講師
1999: Keio University, Internal Medicine, Assistant Professor, 医学部, 講師
1998: 慶應義塾大学, 医学部, 専任講師
1995 – 1996: 慶應義塾大学, 医学部・内科, 講師
1994: Keio Univ., School of Med., Assist.Prof., 医学部, 講師
1993: Internal Medicine Ass.Professor, 医学部・内科, 講師
1991 – 1993: 慶應義塾大学, 医学部, 専任講師
1990: 慶應義塾大学, 医学部・消化器内科, 助手 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology
Except Principal Investigator
Gastroenterology / Virology
Keywords
Principal Investigator
肝細胞癌 / promoter activity / interferon regulatory factor-1 / プロモーター活性 / インターフェロン / 肝癌細胞 / lymphokine activated killer / sodium butyrate / miR-122 / HCV … More / EZH2 / Nrf2 / 脂肪性肝炎 / brusatol / 胆汁酸 / 腸内細菌 / 長鎖飽和脂肪酸 / 高脂肪食STHD-01 / NASH / 高脂肪食摂餌 / microRNA-122 / Nrf-2 / mTOR / エピジェネティック変化 / 肝発癌 / response to the therapy / T helper function / IRF-1 gene polymorphisms / interferon therapy / hepatitis C virus infection / chronic hepatitis C / 免疫反応 / 遺伝子多型 / IRF-1 / Th2細胞 / Th1 / C型ウイルス感染 / 生化学的治療反応 / 治療反応性 / Tヘルパー細胞機能 / C型肝炎ウイルス感染 / インターフェロン治療 / 治療反応 / Tヘルパー活性 / IRF-1遺伝子多型 / ウイルス感染 / C型慢性肝炎 / cell cycle / signal transduction / single nucleotide polymorphisms / sensitivity to drugs / liver cancer cells / interferon / catenin / cadherin / ヒト肝癌細胞株 / 発癌抑制 / インターフェロンα / 細胞周期 / シグナル伝達 / SNP / 薬剤感受性 / nude mouse / laminin / liver-specific antigen / differentiation / hepatoma / LAK感受性 / 細胞骨格蛋白 / 細胞接着分子 / 分化誘導剤 / 分化 / ヌードマウス / ラミニン / 肝特異抗原 / 分化誘導 / 肝癌 / トリコマイシンA / スベロイルアニリドヒドロキサム酸 / apolipoprotein-A1 / osteopontin / レプリコン細胞 / マイクロRNA / エピジェネティクス / ヒストン修飾 / 培養細胞株 / C型肝炎ウイルス / microRNA / ヒストン脱アセチル化酵素阻害薬 / エピゲノム変化 / 肝線維化 / 健康寿命 / 発がん / SOD1ノックアウトマウス / SOD K / 多方向性分化細胞 / 胆管細胞癌 / 四塩化炭素 / DEN / レスベラトロール / 高カロリー(高脂肪)食 / 酸化ストレス / Oマウス / SODK … More
Except Principal Investigator
活性酸素 / nitric oxide / NO / propidium iodide / ischemia-reperfusion / dichlorofluorescin / 共焦点レーザー顕微鏡 / 虚血性肝障害 / Kupffer細胞 / 酸素ストレス / 微小循環 / hepatic differentiation induction method / collagen gel sandwich configuration / stem cell autotransplantation / side population cell / 幹細胞 / コラーゲンゲル / 初代培養肝細胞 / 肝不全 / 肝硬変 / 移植医療 / 細胞融合 / 肝再生 / 自家細胞移植 / 脾臓 / 肝細胞分化 / 肝細胞分化誘導法 / コラーゲンゲルサインドイッチ法 / 幹細胞自家移植療法 / SP細胞 / Laser scanning confocal microscope / Apoptosis / Adhesion molecules / NF-kappaB / TNF-alpha / Kupffer cell / Hepatoma cell / アポトーシス / ミトコンドリア / Nitric Oxide (NO) / apoptosis / 接着因子 / NF-κB / TNF-α / 肝癌 / rhodamine 123 / active oxygen / confocal laser microscopy / microcirculation / ミトコンドリア機能 / 肝移植 / 癌細胞肝転移 / NADH / Propidium iodide / rhodamine123 / metabolome / hepatocellular carcinoma / Hepatitis C virus / 脂質代謝 / 代謝 / ペントースリン酸系 / 持続感染 / C型肝炎ウイルス / 脂肪滴 / メタボローム / Nrf2 / 脂肪酸 / コレステロール / ペントースリン酸経路 / C型肝炎ウイルス / NADH自家蛍光 / ヒト肝癌細胞株 / クッパ-細胞 / 臓器微小循環 / デジタル画像解析 / 細胞障害性 / redox state / 肝障害 / 脂質過酸化反応 / デジタル生体顕微鏡 / 好中球 / 細胞障害活性 / 癌細胞 Less
  • Research Projects

    (11 results)
  • Research Products

    (117 results)
  • Co-Researchers

    (33 People)
  •  Analysis of epigenetic changes via histone modification in liver cancer and development of new therapeutic strategyPrincipal Investigator

    • Principal Investigator
      SAITO Hidetsugu
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Analysis of epigenetic changes in hepatocellular carcinoma and an investigation for a new therapeutic modality targeting histone acetylationPrincipal Investigator

    • Principal Investigator
      SAITO Hidetsugu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Metabolic Analysis of the Cultured Hepatic Cell Persistently Infected with Hepatitis C Virus

    • Principal Investigator
      SUGIYAMA Kazuo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Keio University
  •  The role of anti-oxidative enzyme SOD1 on the development of hepatocellular carcinoma from steatohepatitisPrincipal Investigator

    • Principal Investigator
      SAITO Hidetsugu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Experimental research for treatment of liver failure with hepatic tissue stem cell (SP cell)

    • Principal Investigator
      HORIE Yoshinori, 石井 裕正
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Studies on genomic polymorphisms determining host immune reactions against viral infection and interferon therapyPrincipal Investigator

    • Principal Investigator
      SAITO Hidetsugu
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  STUDY FOR THE CELLULAR MECHANISMS OF INHIBITORY EFFECT OF THE TYPE I INTERFERON ON HEPATOCARCINOGENESIS AND CLINICAL APPLICATIONSPrincipal Investigator

    • Principal Investigator
      SAITO hidetsugu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Mechanism through which Kupffer cell-derived active oxidants mediate hepatoma cell injury

    • Principal Investigator
      KUROSE Iwao
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Analysis of active oxygen metabolism in organ microcirculation using confocal laser microscopy

    • Principal Investigator
      TSUCHIYA Masaharu
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      KEIO University
  •  Regulation of cell growth of hepatoma cells by differentiation inducers and basic investigations for its clinical applicationPrincipal Investigator

    • Principal Investigator
      SAITO Hidetsugu
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  多機能デジタル生体顕微鏡による臓器微小循環障害における酸素ストレスの動的解析

    • Principal Investigator
      TSUCHIYA Masaharu
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University

All 2018 2017 2016 2015 2014 2013 2012 2011 2009 2008 2007

All Journal Article Presentation Book

  • [Book] 成人看護[1] 第14版2018

    • Author(s)
      井関 治和、小澤秀樹、柿崎徹、加行淳子、釼持功、齋藤英胤、佐藤まゆみ、高島尚美、高橋正光、中村威、成毛聖夫、西尾和三、橋本千佳、南川雅子、宮澤光男、棟久恭子、森田南美恵、山口千恵子
    • Total Pages
      427
    • Publisher
      医学書院
    • ISBN
      9784260031806
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Book] やさしい臨床医学テキスト 第4版2018

    • Author(s)
      星 恵子、青山 峰芳、齋藤 英胤、増子 佳世、三木 知博、水谷 顕洋、武藤 章弘、山下 直美
    • Total Pages
      540
    • Publisher
      薬事日報社
    • ISBN
      9784840814232
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Book] アンチエイジング医学の基礎と臨床2008

    • Author(s)
      坪田一男, 木下茂, 斎藤一郎 齋藤英胤, 白澤卓二
    • Total Pages
      455
    • Publisher
      メジカルビュー社
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Book] アンチエイジング・ヘルスフードー抗加齢・疾病予防・健康長寿延長への応用-2007

    • Author(s)
      斉藤 英胤, 水島 裕, 監修
    • Publisher
      サイエンスフォーラム
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice.2018

    • Author(s)
      Yamada S, Takashina Y, Watanabe M, Nagamine R, Saito Y, Kamada N, Saito H.
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 11 Pages: 9925-9939

    • DOI

      10.18632/oncotarget.24066

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03592, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051
  • [Journal Article] Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system2018

    • Author(s)
      Saito Yoshimasa、Nakaoka Toshiaki、Muramatsu Toshihide、Ojima Hidenori、Sukeda Aoi、Sugiyama Yuko、Uchida Ryoei、Furukawa Ryo、Kitahara Aya、Sato Toshiro、Kanai Yae、Saito Hidetsugu
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2821-2821

    • DOI

      10.1038/s41598-018-21121-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26115007, KAKENHI-PROJECT-17H06176, KAKENHI-PROJECT-17H03592, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051, KAKENHI-PROJECT-16H02472
  • [Journal Article] Nrf2-mediated anti-oxidant effects contribute to suppression of non-alcoholic steatohepatitis associated hepatocellular carcinoma in murine model2018

    • Author(s)
      Yamada S、Kimura M、Saito Y、Saito H
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: in press

    • NAID

      130007480019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Journal Article] Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling2017

    • Author(s)
      Teratani Toshiaki、Tomita Kengo、Suzuki Takahiro、Furuhashi Hirotaka、Irie Rie、Hida Shigeaki、Okada Yoshikiyo、Kurihara Chie、Ebinuma Hirotoshi、Nakamoto Nobuhiro、Saito Hidetsugu、Hibi Toshifumi、Miura Soichiro、Hokari Ryota、Kanai Takanori
    • Journal Title

      Journal of Hepatology

      Volume: 67 Issue: 4 Pages: 780-790

    • DOI

      10.1016/j.jhep.2017.05.020

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08756, KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-15K19348, KAKENHI-PROJECT-15K09031
  • [Journal Article] Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids.2017

    • Author(s)
      Nakaoka T, Saito Y, Shimamoto Y, Muramatsu T, Kimura M, Kanai Y, Saito H.
    • Journal Title

      Cancer Sci,

      Volume: 108 Issue: 4 Pages: 678-684

    • DOI

      10.1111/cas.13165

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02472, KAKENHI-PROJECT-26290049, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051, KAKENHI-PROJECT-17H03592
  • [Journal Article] Detection of bacterial DNA by in situ hybridization in patients with decompensated liver cirrhosis2017

    • Author(s)
      Usui S、Ebinuma H、Chu P-S、Nakamoto N、Yamagishi Y、Saito H、Kanai T
    • Journal Title

      BMC Gastroenterology

      Volume: 17 Issue: 1 Pages: 106-106

    • DOI

      10.1186/s12876-017-0664-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Journal Article] On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon-free therapy for chronic hepatitis C2017

    • Author(s)
      Chu Po-sung、Nakamoto Nobuhiro、Taniki Nobuhito、Ojiro Keisuke、Amiya Takeru、Makita Yuko、Murata Hiroko、Yamaguchi Akihiro、Shiba Shunsuke、Miyake Rei、Katayama Tadashi、Ugamura Aya、Ikura Akihiko、Takeda Karin、Ebinuma Hirotoshi、Saito Hidetsugu、Kanai Takanori
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 6 Pages: e0179096-e0179096

    • DOI

      10.1371/journal.pone.0179096

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09373, KAKENHI-PROJECT-15K09021
  • [Journal Article] Commensal Lactobacillus controls immune tolerance during acute liver injury in mice2017

    • Author(s)
      Nakamoto N, Amiya T, Aoki R, Taniki N, Koda Y, Miyamoto K, Teratani T, Suzuki T, Chiba S, Chu PS, Hayashi A, Yamaguchi A, Shiba S, Miyake R, Katayama T, Suda W, Mikami Y, Kamada N, Ebinuma H, Saito H, Hattori M, Kanai T
    • Journal Title

      Cell Reports

      Volume: 5 Issue: 5 Pages: 1215-1226

    • DOI

      10.1016/j.celrep.2017.10.022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15K09021
  • [Journal Article] Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis.2017

    • Author(s)
      Yamada S, Kamada N, Amiya T, Nakamoto N, Nakaoka T, Kimura M, Saito Y, Ejima C, Kanai T, Saito H.
    • Journal Title

      BMC Gastroenterology

      Volume: 17 Issue: 1 Pages: 136-136

    • DOI

      10.1186/s12876-017-0689-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03592, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051
  • [Journal Article] Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma.2017

    • Author(s)
      Nakaoka T, Saito Y, Saito H.
    • Journal Title

      International Journal of Molecular Science

      Volume: 18 Issue: 6 Pages: 1111-1111

    • DOI

      10.3390/ijms18061111

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H03592, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051
  • [Journal Article] Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response.2016

    • Author(s)
      Saito Y, Nakaoka T, Sakai K, Muramatsu T, Toshimitsu K, Kimura M, Kanai T, Sato T, Saito H
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 25311-25311

    • DOI

      10.1038/srep25311

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26290049, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051
  • [Journal Article] microRNA-mediated resistance to hypoglycemia in the HepG2 human hepatoma cell line.2016

    • Author(s)
      Ueki S, Murakami Y, Yamada S, Kimura M, Saito Y, Saito H
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 732-732

    • DOI

      10.1186/s12885-016-2762-7

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26290049, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-16K13051
  • [Journal Article] マイクロ RNA の発現異常は肝発癌にどのようにかかわっているのか?2015

    • Author(s)
      齋藤義正、齋藤英胤、金井弥栄.
    • Journal Title

      分子消化器病

      Volume: 12 Pages: 540-541

    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Journal Article] Genotype-associated differential NKG2D expression on CD56+CD3+lymphocytes predicts response to pegylated-Interferon/ribavirin therapy in chronic hepatitis C.2015

    • Author(s)
      Chu P S, Ebinuma H, Nakamoto N, Sugiyama K, Usui S, Wakayama Y, Taniki N, Yamaguchi A, Shiba S, Yamagishi Y, Wakita T, Hibi T, Saito H, Kanai T.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 5 Pages: e0125664-e0125664

    • DOI

      10.1371/journal.pone.0125664

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Journal Article] microRNA-34a as a therapeutic agent against human cancer.2015

    • Author(s)
      Saito Y, Nakaoka T, Saito H.
    • Journal Title

      J Clin Med

      Volume: 4 Issue: 11 Pages: 1951-1959

    • DOI

      10.3390/jcm4111951

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-26290049
  • [Journal Article] Inhibitors of enhancer of zeste homolog 2 (EZH2) activate tumor-suppressor microRNAs in human cancer cells2014

    • Author(s)
      Hibino S, Saito Y, Muramatsu T, Otani A, Kasai Y, Kimura M, Saito H
    • Journal Title

      Oncogenesis

      Volume: 3 Issue: 5 Pages: e104-e104

    • DOI

      10.1038/oncsis.2014.17

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24590993
  • [Journal Article] Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells.2014

    • Author(s)
      Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, Usui S, Furuhashi H, Kimura A, Nishiyama K, Maejima T, Okada Y, Kurihara C, Shimamura K, Ebinuma H, Saito H, Yokoyama H, Watanabe C, Komoto S, Nagao S, Sugiyama K, Aosasa S, Hatsuse K, Yamamoto J, Hibi T, Miura S, Hokari R, Kanai T.
    • Journal Title

      Journal of Hepatology

      Volume: 印刷中 Issue: 1 Pages: 98-106

    • DOI

      10.1016/j.jhep.2014.03.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591001, KAKENHI-PROJECT-24590993, KAKENHI-PROJECT-24790719
  • [Journal Article] Alterations of epigenetics and microRNA in hepatocellular carcinoma2014

    • Author(s)
      Saito Y, Hibino S, Saito H
    • Journal Title

      Hepatol Res

      Volume: 44(1) Issue: 1 Pages: 31-42

    • DOI

      10.1111/hepr.12147

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24590993
  • [Journal Article] Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus2014

    • Author(s)
      Sugiyama, K. Ebinuma, H. Nakamoto, N. Sakasegawa, N. Murakami, Y. Chu, P. S. Usui, S. Ishibashi, Y. Wakayama, Y. Taniki, N. Murata, H. Saito, Y. Fukasawa, M. Saito, K. Yamagishi, Y. Wakita, T. Takaku, H. Hibi, T. Saito, H. Kanai, T.
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 4 Pages: 849-854

    • DOI

      10.1371/journal.pone.0094460

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-24590557, KAKENHI-PROJECT-24590993
  • [Journal Article] Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice2014

    • Author(s)
      Tomita, K. Teratani, T. Suzuki, T. Shimizu, M. Sato, H. Narimatsu, K. Okada, Y. Kurihara, C. Irie, R. Yokoyama, H. Shimamura, K. Usui, S. Ebinuma, H. Saito, H. Watanabe, C. Komoto, S. Kawaguchi, A. Nagao, S. Sugiyama, K. Hokari, R. Kanai, T. Miura, S. Hibi, T.
    • Journal Title

      Hepatology

      Volume: 59 Issue: 1 Pages: 154-169

    • DOI

      10.1002/hep.26604

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-23591001, KAKENHI-PROJECT-24249046, KAKENHI-PROJECT-24390190, KAKENHI-PROJECT-24590993, KAKENHI-PROJECT-24790719
  • [Journal Article] Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis.2014

    • Author(s)
      Takaki Y, Saito Y, Takasugi A, Toshimitsu K, Yamada S, Muramatsu T, Kimura M, Sugiyama K, Suzuki H, Arai E, Ojima H, Kanai Y, Saito H.
    • Journal Title

      Cancer Sci.

      Volume: 105 Issue: 10 Pages: 1254-1260

    • DOI

      10.1111/cas.12498

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590993, KAKENHI-PROJECT-25460487, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26290049, KAKENHI-PROJECT-221S0001
  • [Journal Article] Epigenetic Alterations and MicroRNA Misexpression in Cancer and Autoimmune Diseases : a Critical Review2013

    • Author(s)
      Saito Y, Saito H, Liang G, Friedman JM
    • Journal Title

      Clin Rev Allergy Immunol

      Volume: 47 Issue: 2 Pages: 128-135

    • DOI

      10.1007/s12016-013-8401-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24590993
  • [Journal Article] Suppressive Effect of the Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), on Hepatitis C Virus Replication via Epigenetic Changes in Host Cells2013

    • Author(s)
      Sato, A., Saito, Y., Sugiyama, K., Sakasegawa, N., Muramatsu, T., Fukuda, S., Yoneya, M., Kimura, M., Ebinuma, H., Hibi, T., Saito, H
    • Journal Title

      J Cell Biochem

      Volume: 印刷中 Issue: 9 Pages: 1987-1996

    • DOI

      10.1002/jcb.24541

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24590993, KAKENHI-PROJECT-25293110
  • [Journal Article] C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice.2013

    • Author(s)
      Chu PS, Nakamoto N, Ebinuma H, Usui S, Saeki K, Matsumoto A, Mikami Y, Sugiyama K, Tomita K, Kanai T, Saito H, Hibi T.
    • Journal Title

      Hepatology

      Volume: 58 Issue: 1 Pages: 337-350

    • DOI

      10.1002/hep.26351

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J05920, KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-23591001, KAKENHI-PROJECT-24249046
  • [Journal Article] A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells2012

    • Author(s)
      Teratani T, Tomita K, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Tominaga S, Hiroi S, Irie R, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Kanai T, Miura S, Hibi T
    • Journal Title

      Gastroenterology

      Volume: 142 Issue: 1 Pages: 152-164

    • DOI

      10.1053/j.gastro.2011.09.049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-23591001
  • [Journal Article] Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules.2012

    • Author(s)
      Dua H, Yoshimura K, Kobayashi N, Sugiyama K, Sawada JI, Saito Y, Morisseau C, Hammock BD, Akatsuka T
    • Journal Title

      Toxicol. Appl. Pharmacol

      Volume: 260 Pages: 17-26

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Journal Article] Role of CTCF in the regulation of microRNA expression2012

    • Author(s)
      Saito Y, Saito H
    • Journal Title

      Front Genet

      Volume: 3 Pages: 186-186

    • DOI

      10.3389/fgene.2012.00186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24590993
  • [Journal Article] A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells.2012

    • Author(s)
      Teratani T, Tomita K, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Tominaga S, Hiroi S, Irie R, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Kanai T, Miura S, Hibi T.
    • Journal Title

      Gastroenterology

      Volume: 142

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Journal Article] p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.2012

    • Author(s)
      Tomita K, Teratani T, Shimamura K, Nishiyama N, Mataki R, Irie T, Minamino Y, Okada C, Kurihara H, Sugiyama K, et al
    • Journal Title

      J Hepatol

      Volume: 57 Issue: 4 Pages: 837-843

    • DOI

      10.1016/j.jhep.2012.05.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-23591001, KAKENHI-PROJECT-24790719
  • [Journal Article] Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules.2012

    • Author(s)
      Duan H, Yoshimura K, Kobayashi N, Sugiyama K, Sawada JI, Saito Y, Morisseau C, Hammock BD, Akatsuka T
    • Journal Title

      Toxicol.

      Volume: 260 Issue: 1 Pages: 17-26

    • DOI

      10.1016/j.taap.2012.01.023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Journal Article] MicroRNAs in cancers and neurodegenerative disorders2012

    • Author(s)
      Saito Y, Saito H
    • Journal Title

      Front Genet

      Volume: 3 Pages: 194-194

    • DOI

      10.3389/fgene.2012.00194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24590993
  • [Journal Article] Treatment of hepatitis C virus with peg-interferon and ribavirin combination therapy significantly affects lipid metabolism2009

    • Author(s)
      S. Tada, H. Saito, H. Ebinuma, K. Ojiro, Y. Yamagishi, N. Kumagai, Y. Inagaki, T. Masuda, J. Nishida, M. Takahashi, H. Nagata, T. hibi
    • Journal Title

      Hepatol. Res 39(2)

      Pages: 195-199

    • NAID

      10025324600

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] New mechanism of transforming growth factor-beta signaling in hepatoma : Dramatic up-regulation of tumor initiating cells and epidermal growt hfactor receptor expression2009

    • Author(s)
      T. Nishimura, T. Azuma, A. Yokoyama, H. Ochiai, H. Saito, T. Hibi
    • Journal Title

      Hepatol. Res 39

      Pages: 501-509

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Treatment of hepatitis C virus with peg-interferon and ribavir in combination therapy significantly affects lipid metabolism2009

    • Author(s)
      S. Tada, H. Saito, H. Ebinum a, et al.
    • Journal Title

      Hepatol. Res. 39

      Pages: 195-199

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Transmission of hepatitis B virus (HBV) genotypes among Japanese immigrants and natives in Bolivia2008

    • Author(s)
      A. Khan, Y. Tanaka, H. Saito, H. Ebinuma, H. Sekiguchi, H. Iwama, G. Wakabayashi, T. Kamiya, F. Kurbanov, A. Elkady, M. Mizokami
    • Journal Title

      Virus Res 132(1-2)

      Pages: 174-180

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Hypofractionated stereotactic radiotherapy with and without transarterial chemo-embolizationfor small hepatocellular carcinoma not eligible for other ablation therapies : Preliminary results for efficacy and toxicity2008

    • Author(s)
      A. Takeda, M. Takahashi, E. Kunieda, T. Takeda, N. Sanuki, Y. Koike, K. Atsukawa, T. Ohashi, H. Saito, N. Shigematsu, A. Kubo
    • Journal Title

      Hepatol. Res 38(1)

      Pages: 60-68

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Reactivation of hepatitis B in a patient with Crohn's disease treated using infliximab2008

    • Author(s)
      K. Ojiro, M. Naganuma, H. Ebinuma, H. Kunimoto, S. Tada, H. Ogata, Y. Iwao, H. Saito, T. Hibi
    • Journal Title

      J. Gastroenterol 43(5)

      Pages: 397-401

    • NAID

      10021268818

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Advances in henomic research on hepatitis C virus with a useful tool2008

    • Author(s)
      M. Nakamura, H. Saito, T. Hibi
    • Journal Title

      replicon system. Keio J. Med 57(2)

      Pages: 75-83

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] 肝発癌のケモプリベンション:理論と実際2008

    • Author(s)
      斉藤 英胤
    • Journal Title

      日本内科学会雑誌 98

      Pages: 92-98

    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Possible molecular mechanism of the relationship between NS5B polymorphisms and early clearance of hepatitis C virus during interferon plus ribavirin treatment2008

    • Author(s)
      M. Nakamura, H. Saito, M. Ikeda, S. Tada, N. Kumagai, N. Kato, K. Shimotohno, T. Hibi
    • Journal Title

      J. Med. Virol 80(4)

      Pages: 632-663

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Possible molecular mechanism of the relationship between NS5B polym orphisms and early clearance of hepatitis C virus during interferon plus ribavirin treatment.2008

    • Author(s)
      M. Nakamura, H. Saito, M. Ikeda, et al.
    • Journal Title

      J. Med. Virol. 80

      Pages: 632-663

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Complexity of the HVR-1 quasispecies and disease activity in patients with hepatitis C2007

    • Author(s)
      N. Kumagai, F. Kaneko, S. Tsunematsu, K. Tsuchimoto, S. Tada, H. Saito, T. Hibi
    • Journal Title

      Eur. J. Clin. Invest 37

      Pages: 566-572

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis2007

    • Author(s)
      K. Kitamura, S. Tada, N. Nakamoto, K. Toda, H. Horikawa, S. Kurita, S. Tsunematsu, N. Kumagai, H. Ishii, H. Saito, T. Hibi
    • Journal Title

      J. Gastroenterol. Hepatol 22

      Pages: 2022-2033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Possible Inhibitory Effect of Oral Zinc Supplementation on Hepatic Fibrosis Through Downregulation of TIMP-1:A Pilot Study2007

    • Author(s)
      M. Takahashi, H. Saito, et. al.
    • Journal Title

      Hepatology Research 37

      Pages: 405-409

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Journal Article] Possible Inhibitory Effect of Oral Zinc Supplementation on Hepatic Fibrosis Through Downregulation of TIMP-1 : A Pilot Study2007

    • Author(s)
      M. Takahashi, H. Saito, M. Higashimoto, T. Hibi
    • Journal Title

      Hepatol. Res 37

      Pages: 405-409

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Presentation] Integrated collaboration of intestinal microbiota induces bacterial translocation and Th17 immune response in primary sclerosis cholangitis2017

    • Author(s)
      Nakamoto N, Aoki R, Sasaki N, Taniki N, Chu P-S, Yamaguchi A, Shiba S, Saito H, Sato T, Kanai, T.
    • Organizer
      AASLD The Liver Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] 脂肪細胞における老化関連遺伝子の発言変化と高脂肪食摂取およびDNAメチル化阻害薬の影響2017

    • Author(s)
      木村真規、井出晴香、白井栄里奈、内田諒英、齋藤義正、齋藤 英胤
    • Organizer
      日本抗加齢医学会総会
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] 胆管がんオルガノイドにおける糖欠乏下での幹細胞性の増強2017

    • Author(s)
      吉川直、齋藤義正、齋藤 英胤
    • Organizer
      日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] 急性肝不全を呈する急性肝炎様自己免疫性肝炎の予後予測因子についての解析2017

    • Author(s)
      尾城啓輔、中本伸宏、Chu P-S、宇賀村文、武田果林、三宅麗、志波俊輔、山口晃弘、谷木信仁、海老沼浩利、齋藤英胤、金井隆典.
    • Organizer
      日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] Ferritin as a biomarker for detecting early recurrence of HCC after IFN-free DAAs: an observational study2017

    • Author(s)
      Yamaguchi A, Chu P-S, Nakamoto N, Ugamura A, Shiba S, Miyake R, Taniki N, Ebinuma H, Saito H, Kanai T.
    • Organizer
      AASLD The Liver Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] Modification of the MELD score with serological fibrosis markers reflecting extracellular matrix remodeling improves prediction of outcomes in non-acetaminophen-associated acute liver failure2017

    • Author(s)
      Ugamura A, Chu P-S, Nakamoto N, Taniki N, Takeda K, Ebinuma H, Saito H, Kanai T.
    • Organizer
      AASLD The Liver Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] Decrease of platelet count predicts de novo hepatocellular carcinoma in chronic hepatitis B patients who achieved sustained virological effect under long-term nucleus(t)ide analogues.2017

    • Author(s)
      Miyake R, Chu P-S, Ikura A, Takeda K, Ugamura A, Shiba S, Yamaguchi A, Taniki N, Nakamoto N, Saito H, Kanai T.
    • Organizer
      AASLD The Liver Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] DNAメチル化阻害による抗ウイルス免疫応答の活性化を介した胆管がんオルガノイドの増殖抑制2017

    • Author(s)
      古川遼、齋藤義正、齋藤 英胤
    • Organizer
      日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] 高脂肪食負荷NASH-HCCモデルにおける腸内細菌叢代謝物と肝内免疫細胞の検討2017

    • Author(s)
      山田翔士、長峯僚吾、木村真規、齋藤義正、齋藤英胤
    • Organizer
      日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] Nicotinamide N-methyltransferase regulates hepatic immunity via gut-liver axis2017

    • Author(s)
      Taniki N, Nakamoto N, Mikami Y, Chu P-S, Ugamura A, Shiba S, Miyake R, Yamaguchi A, Amiya T, Ebinuma H, Saito H, Kanai T.
    • Organizer
      AASLD The Liver Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] HCV関連肝細胞癌既往のある症例におけるDAA治療後早期再発因子の検討2017

    • Author(s)
      山口晃弘、Chu P-S、武田果林、宇賀村文、三宅麗、志波俊輔、谷木信仁、尾城啓輔、中本伸宏、海老沼浩利、齋藤英胤、金井隆典.
    • Organizer
      日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] NASHを背景とした肝発癌におけるケモカイン受容体CCR9の治療標的としての可能性2017

    • Author(s)
      三宅麗、中本伸宏、網谷猛、武田果林、伊倉顕彦、瀧本洋一、宇賀村文、片山正、志波俊輔、山口晃弘、谷木信仁、Chu P-S、齋藤 英胤、金井隆典
    • Organizer
      日本消化器免役学会総会
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] 腸管上皮オルガノイドにおけるエピゲノム変化に着目したステムセルエイジングの解明2017

    • Author(s)
      齋藤義正、内田諒英、村松俊英、木村真規、齋藤 英胤
    • Organizer
      日本抗加齢医学会総会
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] Gut microbiota-mediated changes in liver bile acids composition elicit mTOR signaling.2017

    • Author(s)
      Yamada S, Watanabe M, Saito H
    • Organizer
      AASLD The Liver Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] かん(肝)細胞とかん(幹)細胞2017

    • Author(s)
      齋藤英胤
    • Organizer
      日本抗加齢医学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] 肥満細胞における老化関連遺伝子の発現変化とDNAメチル化阻害薬投与の影響2017

    • Author(s)
      木村真規、井出晴香、白井栄里奈、内田諒英、齋藤義正、Whitehead JP、齋藤 英胤
    • Organizer
      日本肥満学会
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response.2016

    • Author(s)
      Saito Y, Sakai K, Toshimitsu K, Muramatsu T, Nakaoka T, Kimura M, Saito H.
    • Organizer
      Annual Meeting of American Association for Cancer Research (AACR)
    • Place of Presentation
      ニューオリンズ(アメリカ)
    • Year and Date
      2016-04-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] 高脂肪食・抗生物質によるマウス脂肪性肝疾患の病態変化に伴う肝内免疫細胞の検討.2016

    • Author(s)
      山田翔士、中本伸宏、金井隆典、齋藤英胤
    • Organizer
      第53回日本消化器免疫学会総会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2016-07-14
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] 高脂肪食摂取時の脂肪組織における老化マーカー遺伝子の発現変化とDNAメチル化阻害薬の効果.2016

    • Author(s)
      木村真規、井手晴香、白井栄里奈、内田諒英、齋藤義正、齋藤英胤.
    • Organizer
      第16回 日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-06-10
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] Relationship between changing of gut microbiota and the pathogenesis of bile and fatty acids in a mouse model of non alcoholic steatohepatitis.2016

    • Author(s)
      Yamada S, Watanabe M, Saito H.
    • Organizer
      EASL International Liver Congress
    • Place of Presentation
      バルセロナ(スペイン)
    • Year and Date
      2016-04-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] 肝臓内免疫応答・免疫寛容病態への腸管相関を介した疾患特異的腸内細菌の関与.2016

    • Author(s)
      中本伸宏、谷木信仁、網谷猛、青木亮、海老沼浩、楮柏松、山口晃弘、志波俊輔、三宅麗、片山正、齋藤英胤、金井隆典.
    • Organizer
      第53回日本消化器免疫学会総会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2016-07-14
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] The gut-liver axis plays a crucial role in murine immune tolerance in the liver.2015

    • Author(s)
      Nakamoto N, Ebinuma H, Chu-P-S, Taniki N, Amiya T, Yamaguchi A, Shiba S, Saito H, Kanai T.
    • Organizer
      66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] 高脂肪食による腸内細菌叢と胆汁酸および関連トランスポーター発現の変化.2015

    • Author(s)
      山田翔士、渡辺光博、齋藤英胤.
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本県・熊本市
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] 高コレステロール食マウス肝病態と胆汁酸・腸内細菌動態の検討.2015

    • Author(s)
      齋藤英胤、山田翔士、渡辺光博.
    • Organizer
      第57回日本消化器病学会大会
    • Place of Presentation
      東京都・品川区
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] EZH2 阻害薬によるがん抑制マイクロRNA の活性化と肝発がん抑制.2015

    • Author(s)
      齋藤義正,日比野沙奈,村松俊英,木村真規,杉山和夫,海老沼浩利,金井隆典,齋藤英胤.
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本県・熊本市
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] マウスNASH様モデルの病態形成における腸内細菌叢と代謝物変化に基づく新たな治療標的.2015

    • Author(s)
      山田翔士、江島智子、齋藤英胤.
    • Organizer
      第101回日本消化器病学会総会
    • Place of Presentation
      宮城県・仙台市
    • Year and Date
      2015-04-23
    • Data Source
      KAKENHI-PROJECT-15K09021
  • [Presentation] メタボローム・トランスクリプトーム統合的解析によるC型肝炎肝脂肪蓄積の機構解明.2013

    • Author(s)
      杉山和夫、齋藤英胤、日比紀文.
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24590993
  • [Presentation] HCV持続感染細胞における転写因子Nrf2に制御される遺伝子群の発現解析2013

    • Author(s)
      酒瀬川典子、杉山和夫、海老沼浩利、中本伸宏、村上優子、齋藤英胤、金井隆典
    • Organizer
      第61回日本ウイルス学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] ヒストン修飾制御薬によるマイクロRNAを介した抗がん作用の検討.2013

    • Author(s)
      日比野沙奈、齋藤義正、村松俊英、大谷亜希、笠井雄佑、植木里美、山田翔士、木村真規、齋藤英胤.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24590993
  • [Presentation] HCV感染細胞における転写因子Nrf2によって制御される遺伝子群の発現解析.2013

    • Author(s)
      酒瀬川典子、杉山和夫、海老沼浩利、中本伸宏、村上優子、齋藤英胤、金井隆典.
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24590993
  • [Presentation] Epigenetic作用薬を用いたC型肝炎ウイルスの制御:ヒストン脱アセチル化阻害薬の有用性.2013

    • Author(s)
      齋藤英胤、齋藤義正、杉山和夫.
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24590993
  • [Presentation] Nrf2/sMaf転写因子複合体はHCVによる肝細胞脂肪蓄積に関与する.2013

    • Author(s)
      杉山和夫、海老沼浩利、酒瀬川典子、齋藤義正、金井隆典、日比紀文、齋藤英胤.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24590993
  • [Presentation] Nrf2/sMaf転写因子複合体はHCVによる肝細胞脂肪蓄積に関与する2013

    • Author(s)
      杉山和夫、海老沼浩利、酒瀬川典子、齋藤義正、金井隆典、日比紀文、齋藤英胤
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] メタボローム・トランスクリプトーム統合的解析によるC型肝炎肝脂肪蓄積の機構解明2013

    • Author(s)
      杉山和夫、齋藤英胤,日比紀文
    • Organizer
      第16回日本肝臓学会大会(JDDW 2013)
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] Epigenetics作用薬を用いたC型肝炎ウイルスの制御 ヒストン脱アセチル化阻害薬の有用性2013

    • Author(s)
      齋藤 英胤、齋藤 義正、杉山 和夫
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] MiR-1246 and miR-302 are novel target of epigenetic therapy with DZNep and SAHA in human cancer cells.2013

    • Author(s)
      Hibino S, Saito Y, Muramatsu T, Otani A, Kasai Y, Kimura M, Saito H.
    • Organizer
      Digestive Disease Week 2013
    • Place of Presentation
      Orlando, USA
    • Data Source
      KAKENHI-PROJECT-24590993
  • [Presentation] Usefulness of a long-term (over 2 years) cultured cell clone persistently and productively infected with chimeric HCV2012

    • Author(s)
      Sugiyama, K, Saito H, Ebinuma H, Sakasegawa N, Murakami Y, Nakamoto N, Usui S, Ishibashi Y, Chu P, Wakayama Y, Saito Y, Kanai T, Hibi T
    • Organizer
      The 63rd annual meeting of the American association for the study of liver diseases
    • Place of Presentation
      Boston USA
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] 長期間の持続感染培養肝細胞におけるHCVゲノムの自然発生的遺伝子変異の解析2012

    • Author(s)
      酒瀬川典子, 杉山和夫, 齋藤英胤, 海老沼浩利, 村上優子, 中本伸宏, 金井隆典, 日比紀文
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] 新たなHCV研究ツールとしてのHCV持続感染培養肝細胞およびその治癒細胞の樹立2012

    • Author(s)
      杉山和夫, 齋藤英胤, 酒瀬川典子, 村上優子, 海老沼浩利, 中本伸宏, 梅田瑠美子, 碓井真吾, 石橋由佳, 楮柏松, 若山遊子, 齋藤義正, 日比紀文
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] C型肝炎ウイルス持続感染における肝発癌と免疫異常:高発癌リスク因子を中心とした検討2012

    • Author(s)
      楮柏松, 海老沼浩利, 中本伸宏, 碓井真吾, 梅田瑠美子, 石橋由佳, 若山遊子, 菊池真大, 山岸由幸, 杉山和夫, 金井隆典, 齋藤英胤, 日比紀文
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] Usefulness of long-term (over 2 years) cultured cell clone persistently and productively infected with chimeric HCV.2012

    • Author(s)
      Sugiyama K, Saito H, Ebinuma H, Sakasegawa N, Murakami Y, Nakamoto N, Usui S, Ishibashi Y, Chu P-S, Wakayama Y, Saito Y, Kanai T, Hibi T.
    • Organizer
      63th Annual Meeting of American Association for the Study of Liver Diseases (AASLD)
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-24590993
  • [Presentation] コレステロール多量摂取は、肝星細胞の遊離コレステロール蓄積を介して、肝臓繊維化進展を引き起こす2012

    • Author(s)
      冨田謙吾, 寺谷俊昭, 鈴木貴博, 横山裕一, 岡田義清, 栗原千枝, 海老沼浩利, 齋藤英胤, 渡辺知佳子, 高本俊介, 穂刈量太, 川口淳, 永尾重昭, 杉山和夫, 金井隆典, 日比紀文, 三浦総一郎
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] HCV研究私の研究とSerendipity、C型肝炎ウイルス持続感染培養肝細胞の樹立と応用2012

    • Author(s)
      杉山和夫、齋藤英胤,日比紀文
    • Organizer
      第39回日本肝臓学会東部会
    • Place of Presentation
      東京(シンポジウム)
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] Recruited CCR9+ macrophages promote murine liver fibrosis through induction of TGF-β in hepatic stellate cells.2012

    • Author(s)
      Chu P, Nakamoto N, Ebinuma H, Usui S, Sugiyama K, Kanai T, Saito H, Hibi T
    • Organizer
      The 63rd annual meeting of the American association for the study of liver diseases
    • Place of Presentation
      Boston USA
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] New Insights on Hepatic Inflammatory Pseudotumor by Gd-EOB-DTPA MR Imaging2012

    • Author(s)
      Usui S, Chu P, Wakayama Y, Ishibashi Y, Nakamoto N, Yamagishi Y, Masugi Y, Ebinuma H, Sugiyama K, Tanimoto A, Kanai T, Saito H, Hibi T
    • Organizer
      ACG 2012 Annual Scientific Meeting
    • Place of Presentation
      Las Vegas, USA
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] 当院における免疫抑制剤投与中のHBV感染の現状2012

    • Author(s)
      碓井真吾, 海老沼浩利, 若山遊子, 楮柏松, 石橋由佳, 中本伸宏, 山岸由幸, 杉山和夫, 金井隆典, 齋藤英胤, 日比紀文
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] Peginterferon (PEG)/ Rivabirin (RBV)併用療法の治療成績からみた高齢者とりわけ高齢女性にたいする今後の治療展望2012

    • Author(s)
      海老沼浩利, 齋藤英胤, 中本伸宏, 山岸由幸, 碓井真吾, 梅田瑠美子, 楮柏松, 石橋由佳, 若山遊子, 杉山和夫, 金井隆典, 日比紀文
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] 1b型HCVレプリコン複製細胞内のレプリコンRNAを効率よく感染性粒子としてtranspackagingする方法2012

    • Author(s)
      村上優子, 杉山和夫, 齋藤英胤, 海老沼浩利, 中本伸宏, 酒瀬川典子, 斉藤聡, 金井隆典, 日比紀文, 高久洋
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] Usefulness of A Long-term (Over 2 years) Cultured Cell Clone Persistently and Productively Infected with HCV2012

    • Author(s)
      Sugiyama K, Saito H, Sakasegawa N, Murakami Y, Ebinuma H, Nakamoto N, Usui S, Ishibashi Y, Chu P, Wakayama Y, Saito Y, Kanai T, Hibi T
    • Organizer
      The 63rd Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] ヒストン脱アセチル化酵素阻害剤suberoylanilide hydroxamic acid (SAHA)によるC型肝炎ウイルス(HCV)の増殖抑制効果2012

    • Author(s)
      佐藤郁美, 齋藤義正, 永見早耶花, 酒瀬川典子, 福田真也, 木村真規, 杉山和夫, 海老沼浩利, 齋藤英胤
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] 新たなHCV研究ツールとしてのHCV持続感染培養肝細胞およびその治癒細胞の樹立2012

    • Author(s)
      杉山和夫、齋藤英胤、酒瀬川典子、村上優子、海老沼浩利、中本伸宏、梅田瑠美子、碓井真吾、石橋由佳、ちょ柏松、若山遊子、齋藤義正、日比紀文
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢(ワークショップ)
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] ヒストン脱アセチル化酵素阻害薬suberoylanilide hydroxamic acid (SAHA)によるC型肝炎ウイルス(HCV)の増殖抑制効果.2012

    • Author(s)
      佐藤郁美、齋藤義正、永見早耶花、酒瀬川典子、福田真也、木村真規、杉山和夫、海老沼浩利、齋藤英胤.
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-24590993
  • [Presentation] C型肝炎ウイルス持続感染培養肝細胞の樹立と応用.2012

    • Author(s)
      杉山和夫、齋藤英胤、日比紀文.
    • Organizer
      第39回日本肝臓学会東部会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24590993
  • [Presentation] キメラHCV(1b/2a)持続感染細胞のメタボローム解析(Metabolome analysis of the cultured hepatocytes persistently infected with Chimeric HCV (1b/2a)2011

    • Author(s)
      杉山和夫、齋藤英胤、海老沼浩利、高久洋、日比紀文
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] Infectious hepatitis C virus bearing genotype-1b subgenomic replicon by trans-encapsidation with the structural regions of genotype 1b.2011

    • Author(s)
      Sugiyama, K, Murakami Y, Hishiki T, Shimizu Y, Funami K, Ujino S, Saito H, Saito S, Kato N, Hibi T, Takaku H
    • Organizer
      The 18th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Seattle USA
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] Metabolome analysis of the cultured hepatocytes persistently infected with Chimeric HCV (1b/2a).2011

    • Author(s)
      Sugiyama, K. , Saito, H., Ebinuma, H., Takaku, H., Hibi, T.
    • Organizer
      70th Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] Infectious hepatitis C virus bearing genotype-1b subgenomic replicon by trans-encapsidation with the structural regions of genotype 1b.2011

    • Author(s)
      Sugiyama, K., Murakami, Y., Hishiki, T., Shimizu, Y., Funami, K., Ujino, S., Saito, H., Saito, S., Kato, N., Hibi, T., Takaku, H.
    • Organizer
      18th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      シアトル、アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] Age and the liver stiffness measured by Fibroscan are significant predictive values for hepatoma development in chronic liver diseases2011

    • Author(s)
      Ishibashi Y, Ebinuma H, Sugiyama K, Nakamoto N, Yamagishi Y, Usui S, Cho HS, Umeda R, Wakayama Y, Takaishi H, Kanai T, Sakamoto M, Saito H, Hibi T
    • Organizer
      62nd Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco, USA
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] Metabolome analysis of the cultured hepatocytes persistently infected with Chimeric HCV (1b/2a).2011

    • Author(s)
      Sugiyama, K, Saito H, Ebinuma H, Takaku H, Hibi T
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] Nrf2/sMaf転写因子複合体はHCVによる肝細胞脂肪蓄積に関与する2011

    • Author(s)
      杉山和夫、海老沼浩利、酒瀬川典子、齋藤義正、金井隆典、日比紀文、齋藤英胤
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] Significant and continuous elevation of serum total cholesterol levels in patients with chronic hepatitis C who achieved sustained virological response by peginterferon and rivabirin treatment2011

    • Author(s)
      Ebinuma H, Saito H, Sugiyama K, Nakamoto N, Yamagishi Y, Usui S, Cho HS, Umeda R, Ishibashi Y, Wakayama Y, Kanai T, Hibi T
    • Organizer
      62nd Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco, USA
    • Data Source
      KAKENHI-PROJECT-23590551
  • [Presentation] ^<90m>Tc-フチン酸シンチグラフィー検査を用いたNASH診断の有用性に関する検討2009

    • Author(s)
      菊池真大、富田謙吾、中原理紀、北村直人、寺谷俊昭、押川哲也、鈴木貴博、齋藤英胤、日比紀文
    • Organizer
      第95回日本消化器病学会総会(口演)
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-07
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Presentation] 非B非Cアルコール性肝疾患における過形成性結節と肝細胞癌の鑑別2008

    • Author(s)
      菊池真大、山岸由幸、尾城啓輔、海老沼浩利、多田慎一郎、堀江義則、齋藤英胤、加藤真三、日比紀文
    • Organizer
      第37回日本肝臓学会東部会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Presentation] アルコール性肝硬変の進展に関与する因子の検討2008

    • Author(s)
      堀江義則、山岸由幸、菊池真大、齋藤英胤、加藤真三、石井裕正、日比紀文
    • Organizer
      第28回日本アルコール医学生物学研究会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Presentation] 体成分分析装置によるHCC治療前後での入院患者の体成分パラメータ分析. ワークショップ「肝疾患と栄養(NASHを含めて)」2008

    • Author(s)
      尾城啓輔、齋藤英胤、日比紀文
    • Organizer
      第37回日本肝臓学会東部会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Presentation] 肝線維化の定量的測定におけるElastometerの有用性2008

    • Author(s)
      菊池真大、海老沼浩利、山岸由幸、尾城啓輔、金森英彬、富田謙吾、多田慎一郎、堀江義則、齋藤英胤、加藤真三、日比紀文
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Presentation] 肝癌幹細胞におけるTGF-betaシグナルの二面性-細胞動態・遺伝子プロフィールの観点から2008

    • Author(s)
      西村健、東俊文、齋藤英胤、日比紀文
    • Organizer
      第44回日本肝臓学会総会
    • Place of Presentation
      愛媛
    • Data Source
      KAKENHI-PROJECT-19590790
  • [Presentation] マウスNASHモデルにおける亜鉛の抗線維化作用に関する検討2007

    • Author(s)
      熊谷直樹、杉野陽子、渡辺紗希子、戸田京子、金子文彦、常松令、土本寛二、齋藤英胤、日比紀文
    • Organizer
      第11回日本肝臓学会大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19590790
  • 1.  MIURA Soichiro (50138012)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  KUROSE Iwao (50234604)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  KATO Shinzo (30177448)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  TSUCHIYA Masaharu (60051124)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  MASHINO Tadahiko (90165697)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  SAITO Yoshimasa (90360114)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 33 results
  • 7.  HORIE Yoshinori (70229227)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  SAKAMOTO Michiie (40221270)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  TSUBOTA Kazuo (40163878)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  SUGIYAMA Kazuo (10242520)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 34 results
  • 11.  TSUNEMATSU Satoshi (80217356)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TOMITA Kengo (50317129)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  INOKUCHI Sayaka (00383711)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  OKANO Hideyuki (60160694)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  末松 誠 (00206385)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  鈴木 雅之 (70236008)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  高木 珠子 (90286469)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  石井 裕正 (20051500)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  東 俊文 (00222612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  TAKANO Kakuko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KAMADA Nobuhiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KIMURA Masaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 23.  YAMADA Shoji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 24.  NAKAOKA Toshiaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 25.  ITO Hidemi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  斎藤 義正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 20 results
  • 27.  柴田 理恵
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  佐藤 俊朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 29.  金井 弥栄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 30.  チョ ハクショウ
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  尾城 啓輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  海老沼 浩利
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  金井 隆典
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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