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Nagata Kiyoshi  永田 清

ORCIDConnect your ORCID iD *help
… Alternative Names

永田 清  ナガタ キヨシ

NAGATA Kiyoshi  永田 清

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Researcher Number 80189133
Other IDs
External Links
Affiliation (Current) 2025: 名古屋市立大学, 大学院薬学研究科, 教授
2025: 東北医科薬科大学, 薬学部, 名誉教授
Affiliation (based on the past Project Information) *help 2016 – 2019: 東北医科薬科大学, 薬学部, 教授
2013 – 2015: 東北薬科大学, 薬学部, 教授
2009 – 2011: Tohoku Pharmaceutical University, 薬学部, 教授
2006: Tohoku University Grad. sch. Pharm. Sci., Asscciate Professor, 大学院薬学研究科, 助教授
1999 – 2005: 東北大学, 大学院・薬学研究科, 助教授 … More
2000: 東北大学, 薬学研究科, 助教授
1998: Tohoku Univ., Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授
1994 – 1997: Tohoku Univ., Fac.of Pharm.Sci., Assistant, 薬学部, 助手
1989 – 1994: 慶應義塾大学, 医学部, 助手
1986 – 1987: Assistant prof., School of Medicine, Keio University, 医学部, 助手
1986: Assistant prof., School of Medicine, Keio University, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
応用薬理学・医療系薬学 / Medical pharmacy
Except Principal Investigator
Medical pharmacy / 応用薬理学・医療系薬学 / General pharmacology / Biological pharmacy / 医薬分子機能学
Keywords
Principal Investigator
CYP3A4 / cis-element / in vivo / human / Adenovirus / Induction / P450 / 酵素誘導 / Nuclear Receptor / rat … More / nuclear receptor / PXR / CYP3A1 / Nuclear receptor / sis-element / エンハンサー / シス-エレメント / レポーター / 核内レセプター / 転写因子 / MRP3 / 発現抑制 / マウス / RNAi / アンチセンスRNA / 脳特異的発現 / アデノウイルスベクター / スルホトランスフェラーゼ / 抑制的な調節 / HNF-4 / テストステロン6β-水酸化 / 肝特異的発現 / チトクロームP450 … More
Except Principal Investigator
薬物代謝 / 薬物代謝酵素 / CYP3A / チトクロームP450 / 成長ホルモン / PXR / CYP3A4 / growth hormone / estrogen / androgen / sex-specific cytochrome P-450 / アンドロジェン / エストロジェン / 性特異性チトクロムP-450 / PCN / lithocholic acid / hepatotoxicity / グレープフルーツジュース / 薬物相互作用 / Cytochrome P450 / ヒト薬物代謝 / 個人差 / Gene expression / チトクロムP-450 / Cytochrome P-450 / 酵素誘導 / チトクロームP-450 / フェノバルビタール / 肝細胞 / iPS細胞 / Bile acid / Induction / 硫酸転移酵素 / アリルアミン / 分子記述子 / P450 / DILI評価系 / cytochrome P450 / インビトロDILI 評価系 / インビトロ評価系 / DILI / 薬剤性肝障害 / steroid hormone hydroxylases / ステロイド水酸化酵素 / testosterone hydroxylation / アミノ酸セクエンス / 脳下垂体 / 雌雄固有 / テストステロン水酸化 / P-450-female / P-450-male / phospholipid / cholestasis / microarray / lipid metabolism / リン脂質 / マイクロアレイ / probucol / 胆汁鬱滞 / 肝障害 / 脂質代謝 / induction / nuclear receptor / Lithocholic acid / FXR / Liver toxicity / 誘導 / 核内受容体 / 肝毒性 / human drug metabolism / stable expression / enzyme induction / cyt.P450 / in vivo / スクリーニング / レポーターアッセイ / 安定発現株 / 誘導評価系 / インダクション / 安定発現 / enzyme inhibition / drug metabolism / drug interaction / grapefruit juice / 酵素相互 / グループフルーツジュース / Knock-out mice / Epoxide hydrolase / Teratogenicity / Embryo fibroblast / Thalidomide / 細胞増殖 / 遺伝子欠損マウス / ノックアウトマウス / ノックマウトマウス / エポキシドヒドロラーゼ / 催奇形性 / 胎児線維芽細胞 / サリドマイド / Omeprazole / Gut / Grapefruit juice / Drug interaction / Drug metabolism / 薬物の安全性 / グレープフルーツ / オメプラゾール / 消化管 / Stable Expression / Heterologous expression / Drug Metabolism / cDNA発現 / ミクロソーム / P450還元酵素 / S.Pombe / CYP2C19 / CYP2C18 / CYP2C9 / 遺伝子発現系 / 酵母 / 異種細胞発現 / Sulfotransferase / Acetyltransferase / Metabolic activation / Drug metabolizing enzymes / Carcinogenicity / Mutagenicity / Ames test / ベンチジン / サルモネラ菌 / N,O‐アセチル転移反応 / 異所遺伝子発現 / アセチル化酵素遺伝子 / アセチル化酵素 / Anes試験 / 異種細胞内発現 / アセチル転移酵素 / 代謝活性化 / 発癌性 / 変異原性 / Ames試験 / Diagnosis by gene analysis / Mephenytoin, / Cytochrome P450, / Pharmacogenetics, / Racial difference, / Interindividual differnce, / Drug metabolism, / Drug response, / チトクロムP450 / 遺伝子診断 / メフェニトイン / テトクロームP450 / 薬理遺伝学 / 人種差 / 薬物反応性 / P-450 mixture / Human drug metabolism / ヒト薬物代謝能 / 異所的発現 / チトクロームb_5 / 酵母内遺伝子発現 / ヒト肝 / Dexamethasone / HNF-4 / GRE / Growth hormone / Thyroid hormone / Hepatocyte / Phenobarbital / 初代培養肝細胞 / 単離肝細胞 / チトクロ-ムPー450 / トリヨードチロニン / フェノバルビタール誘導 / 肝核因子-4 / 遺伝子発現 / グルココルチコイド反応性エレメント / 甲状腺ホルモン / 調節因子 / 肝臓チトクロームP-450 / スクラーゼ・イソマルターゼ / 低分子化合物 / トランスポーター / 人工多能性幹細胞 / 薬物動態学 / 分化 / 薬学 / デバイス / 経口バイオアベイラビリティ / 薬物動態 / 薬物トランスポーター / 初回通過効果 / 腸管上皮細胞 / 分化誘導 / ヒトiPS細胞 / 薬物代謝学 / レポーター遺伝子 / EST / ヒト遺伝子 / STICI / RT-PCR / 遺伝子構造 / 分子多型 / 癌原性アリルアミン / 代謝的活性化 / 分子クローニング / スルホトランスフェラーゼ / クロ-ニング / 電子伝達 / チトクロ-ムb_5 Less
  • Research Projects

    (25 results)
  • Research Products

    (107 results)
  • Co-Researchers

    (29 People)
  •  Development of evaluation methods for drug-induced liver injury based on both chemical structure/biological reactivity of drugs and individual factors

    • Principal Investigator
      Sasaki Takamitsu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      University of Shizuoka
  •  Differentiation of human iPS cells into hepatocytes and enterocytes: Development of first pass effect assessment model

    • Principal Investigator
      Matsunaga Tamihide
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Nagoya City University
  •  Development of a model for the monitoring ontogenic expression of CYP3A by used of secreted reporter-expressing iPS cells

    • Principal Investigator
      Sasaki Takamitsu
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      University of Shizuoka
      Tohoku Pharmaceutical University
  •  A new study of enzyme induction involved in pharmacokinetic : Identification of molecular mechanism for a novel enzyme inductionPrincipal Investigator

    • Principal Investigator
      NAGATA Kiyoshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku Pharmaceutical University
  •  Novel protective mechanisms for cholestatic hepatotoxicity-application to drug improving hepatic function

    • Principal Investigator
      MIYATA Masaaki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  直接的なPXR活性化のみがCYP3Aタイプ酵素誘導の機序ではない

    • Principal Investigator
      山添 康
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  Bile acids, key compounds for the mechanistic analyses of hepatotoxicity, and nuclear receptor interaction

    • Principal Investigator
      YAMAZOE Yasushi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tohoku University
  •  脳特異的発現新規スルホトランスフェラーゼのアンチセンスmRNA法を用いた機能解析Principal Investigator

    • Principal Investigator
      永田 清
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University
  •  Human characteristic mechanism of enzyme induction and the prediction

    • Principal Investigator
      YAMAZOE Yasushi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University
  •  Grapefruit juice-drug interaction and the prediction

    • Principal Investigator
      YAMAZOE Yasushi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University
  •  In vivo Molecular Mechanism of Human CYP3A Induction Involved in Drug InteractionPrincipal Investigator

    • Principal Investigator
      NAGATA Kiyoshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University
  •  Analysis of mechanism for thalidomide-induced teratogenicity using knock-out mice

    • Principal Investigator
      MIYATA Masaaki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      Tohoku University
  •  Role of intestinal oxidative metabolism on first pass effect

    • Principal Investigator
      YAMAZOE Yasushi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tohoku University
  •  ヒト発がん感受性に関するアリルアミン硫酸転移酵素の遺伝子の単離と多型性解析

    • Principal Investigator
      山添 康
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
  •  薬物によって誘導される肝特異的P450の遺伝子活性化機構の解析Principal Investigator

    • Principal Investigator
      永田 清
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tohoku University
  •  Development of as table expression system for human drug metabolizing enzymes

    • Principal Investigator
      YAMAZOE Yasushi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tohoku University
  •  癌原物質の活性化を行うヒト肝スルホトランスフェラーゼの構造と遺伝的多型の解析

    • Principal Investigator
      山添 康
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Keio University
  •  Analysis of human interindividual and racial differeness of drug response and metabolism : Approach by the method of diagnosis by gene analysis

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Keio University
  •  Establishment of high sensitive Salmonella tester strains expressing mammalian acetvltransferase and sulfotransferase

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Keio University
  •  Assessment of human drug metabolism by expression of cytochrome P-450 in yeasts.

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Keio University
  •  Regulation of expression of cytochrome P-450 by hormonal factor in primary cultured rat hepatocytes.

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Keio University
  •  薬物代謝に関与するチトクロ-ムb_5のクロ-ニングと発現

    • Principal Investigator
      YAMAZOE Yasushi
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Keio University
  •  下垂体因子による常在型および薬物被誘導型チトクロームP-450の発現とその調節

    • Principal Investigator
      山添 康
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Institution
      Keio University
  •  Molecular mechanism of development and regulation of sex-specific cytochrome P-450 in rat liver

    • Principal Investigator
      KATO Ryuichi
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      School of Medicine, Keio University
  •  Analysis of mechanism of neonatal imprinting of drug-metabolizing enzymes of rat liver

    • Principal Investigator
      YAMAZOE Yasushi, 鎌滝 哲也
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      School of Medicine, Keio University

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2006 2005 2003 Other

All Journal Article Presentation Book

  • [Book] エンドトキシン・自然免疫研究 172014

    • Author(s)
      坂口修平、永田 清
    • Total Pages
      105
    • Publisher
      医学図書出版
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Book] 敗血症の診断・治療の実情と病態・メカニズムをふまえた開発戦略2013

    • Author(s)
      坂口修平、永田 清
    • Total Pages
      12
    • Publisher
      技術情報協会
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Book] 化学物質の代謝・代謝的活性化2011

    • Author(s)
      永田清
    • Publisher
      広川書店
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Book] 薬物代謝酵素の個人変動の要因2010

    • Author(s)
      永田清
    • Publisher
      広川書店
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Book] 医薬品安全性学(医薬品の毒性に影響する要因)(第2版)2010

    • Author(s)
      永田清
    • Total Pages
      19
    • Publisher
      広川書店
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Book] 医薬品の毒性に影響する要因、医薬品安全性学2010

    • Author(s)
      永田清
    • Publisher
      広川書店
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Book] 予防医学としての衛生化学-健康と環境-(薬物代謝酵素の個人変動の要因)2010

    • Author(s)
      永田清
    • Total Pages
      11
    • Publisher
      広川書店
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Book] 酵素誘導、薬物代謝学 第3版2010

    • Author(s)
      永田清
    • Total Pages
      13
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Book] 薬物代謝学、酵素誘導2010

    • Author(s)
      永田清
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Journal Article] CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element2017

    • Author(s)
      Yusuke Aratsu、Reo Odagiri、Rie Shoji、Kouki Watanabe、Takeshi Kumagai、Sawako Shindo、Takamitsu Sasaki、Kiyoshi Nagata
    • Journal Title

      Fundamental Toxicological Sciences

      Volume: 4 Issue: 5 Pages: 229-239

    • DOI

      10.2131/fts.4.229

    • NAID

      130006144718

    • ISSN
      2189-115X
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08419
  • [Journal Article] Effect of health foods on cytochrome P450-mediated drug metabolism2017

    • Author(s)
      Sasaki Takamitsu、Sato Yu、Kumagai Takeshi、Yoshinari Kouichi、Nagata Kiyoshi
    • Journal Title

      Journal of Pharmaceutical Health Care and Sciences

      Volume: 3 Issue: 1 Pages: 14-14

    • DOI

      10.1186/s40780-017-0083-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08419
  • [Journal Article] Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor2016

    • Author(s)
      Kumagai T, Aratsu Y, Sugawara R, Sasaki T, Miyairi S, Nagata K
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 31 Issue: 2 Pages: 139-145

    • DOI

      10.1016/j.dmpk.2016.01.002

    • NAID

      50014431254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Journal Article] Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance-Associated Protein 3 Activation through a Novel Transcriptional Element2016

    • Author(s)
      Sasaki T, Inami K, Numata Y, Funakoshi K, Yoshida M, Kumagai T, Kanno S, Matsui S, Toriyabe T, Yamazoe Y, Yoshinari K, Nagata K
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 31 Issue: 1 Pages: 102-109

    • DOI

      10.1124/jpet.115.231589

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Journal Article] レポーター遺伝子導入培養細胞を用いた健康食品によるCYP1A1/1A2誘導の網羅的評価2016

    • Author(s)
      熊谷 健, 佐々木崇光, 永田 清
    • Journal Title

      医療薬学

      Volume: 42 Pages: 701-708

    • NAID

      130006163861

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Journal Article] Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines.2015

    • Author(s)
      Sato Y, Sasaki T, Takahashi S, Kumagai T, Nagata K
    • Journal Title

      J Pharm Pharm Sci

      Volume: 18 Issue: 4 Pages: 316-327

    • DOI

      10.18433/j3vk5g

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Journal Article] Simultaneous evaluation of human CYP3A4 and ABCB1 induction by reporter assay in LS174T cells, stably expressing their reporter genes2015

    • Author(s)
      Inami K, Sasaki T, Kumagai T, Nagata K
    • Journal Title

      Biopharm Drug Dispos.

      Volume: 36 Issue: 3 Pages: 139-147

    • DOI

      10.1002/bdd.1927

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Journal Article] Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region.2015

    • Author(s)
      Miyauchi Y, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H, Ishii Y
    • Journal Title

      Mol Pharmacol

      Volume: 88 Issue: 4 Pages: 800-812

    • DOI

      10.1124/mol.115.098582

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-25293039
  • [Journal Article] 培養細胞を用いた健康食品と医薬品との薬物相互作用の薬物相互作用の網羅的調査2015

    • Author(s)
      熊谷 健、佐々木崇光、佐藤 裕、髙橋昌悟、細川正清、頭金正博、松永民秀、大森 栄、永田 清
    • Journal Title

      東京都病院薬剤師会雑誌

      Volume: 64 Pages: 15-22

    • Data Source
      KAKENHI-PROJECT-25460195
  • [Journal Article] Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells.2014

    • Author(s)
      Kondo Y, Iwao T, Yoshihashi S, Mimori K, Ogihara R, Nagata K, Kurose K, Saito M, Niwa T, Suzuki T, Miyata N, Ohmori S, Nakamura K, Matsunaga T.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 8 Pages: 1-11

    • DOI

      10.1371/journal.pone.0104010

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25460193, KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-26293036
  • [Journal Article] An Efficient Method for Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-like Cells Retaining Drug Metabolizing Activity2014

    • Author(s)
      Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 29 Issue: 3 Pages: 237-243

    • DOI

      10.2133/dmpk.DMPK-13-RG-104

    • NAID

      130004463382

    • ISSN
      1347-4367, 1880-0920
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390036, KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-25860120
  • [Journal Article] An efficient method for differentiation of human induced pluripotent stem cells into hepatocyte-like cells retaining drug metabolizing activity.2014

    • Author(s)
      Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 29 Pages: 237-243

    • NAID

      130004463382

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293036
  • [Journal Article] Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants2014

    • Author(s)
      Ishii Y, Koba H, Kinoshita K, Oizaki T, Iwamoto Y, Takeda S, Miyauchi Y, Nishimura Y, Egoshi N, Taura F, Morimoto S, Ikushiro S, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H
    • Journal Title

      Drug Metabolism and Disposition

      Volume: 42 Issue: 2 Pages: 229-238

    • DOI

      10.1124/dmd.113.054833

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293039, KAKENHI-PROJECT-25460195
  • [Journal Article] 調剤薬局来局者を対象とした健康食品の使用実態調査とその情報に基づいたCYP2D6活性阻害評価2014

    • Author(s)
      佐々木崇光, 熊谷 健, 佐々木瞳, 稲見敬太, 佐藤 裕, 髙橋昌悟, 松永民秀, 頭金正博, 細川正清, 大森 栄, 永田 清
    • Journal Title

      医療薬学

      Volume: 40 Pages: 488-499

    • NAID

      130005098367

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Journal Article] Differentiation of human induced pluripotent stem cells into functional enterocyte-like cells using a simple method.2014

    • Author(s)
      Iwao T, Toyota M, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A, Nagata K, Matsunaga T
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 29 Pages: 44-51

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293036
  • [Journal Article] Differentiation of Human Induced Pluripotent Stem Cells into Functional Enterocyte-like Cells Using a Simple Method2014

    • Author(s)
      Iwao T et al.
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 29 Issue: 1 Pages: 44-51

    • DOI

      10.2133/dmpk.DMPK-13-RG-005

    • NAID

      130004463343

    • ISSN
      1347-4367, 1880-0920
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390036, KAKENHI-PROJECT-25460195, KAKENHI-PROJECT-25860120
  • [Journal Article] 健康食品と医薬品の併用は薬物相互作用をおこす?2014

    • Author(s)
      永田 清、熊谷 健、 佐々木崇光
    • Journal Title

      医薬品相互作用研究

      Volume: 38 Pages: 23-30

    • Data Source
      KAKENHI-PROJECT-25460195
  • [Journal Article] Polycyclic Aromatic Hydrocarbons Activate CYP3A4 Gene Transcription through Human Pregnane X Receptor2012

    • Author(s)
      Kumagai T, Suzuki H, Sasaki T, Sakaguchi S, Miyairi S, Yamazoe Y, Nagata K
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 27 Issue: 2 Pages: 200-206

    • DOI

      10.2133/dmpk.DMPK-11-RG-094

    • NAID

      130004463240

    • ISSN
      1347-4367, 1880-0920
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590173, KAKENHI-PROJECT-23790193
  • [Journal Article] Polycyclic aromatic hydrocarbons activate CYP3A4 gene transcription through human pregnane X receptor2012

    • Author(s)
      Kumagai T, Suzuki H, Sasaki T, Sakaguchi S, Miyari S, Yamazoe Y, Nagata K
    • Journal Title

      Drug Metab Pharmacokinet.

      Volume: 27 Pages: 200-206

    • URL

      https://www.jstage.jst.go.jp/article/dmpk/27/2/27_DMPK-11-RG-094/_article

    • Data Source
      KAKENHI-PROJECT-21590173
  • [Journal Article] Tumor Necrosis Factor-Alpha-Nuclear Factor-Kappa B-Signaling Enhances St2b2 Expression during 12-O-Tetradecanoylphorbol-13-acetate-Induced Epidermal Hyperplasia2011

    • Author(s)
      T.Matsuda, M.Shimada, A.Sato, T.Akase, K.Yoshinari, K.Nagata, Y.Yamazoe
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 34 Issue: 2 Pages: 183-190

    • DOI

      10.1248/bpb.34.183

    • NAID

      130000402187

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Journal Article] Progression of Alcoholic and Non-alcoholic Steatohepatitis : Common Metabolic Aspects of Innate Immune System and Oxidative Stress2011

    • Author(s)
      Sakaguchi S, Takahashi S, Sasaki T, Kumagai T, Nagata K
    • Journal Title

      Drug Metab Pharmacokinet.

      Volume: 226 Pages: 30-46

    • URL

      https://www.jstage.jst.go.jp/article/dmpk/26/1/26_DMPK-10-RV-087/_article

    • Data Source
      KAKENHI-PROJECT-21590173
  • [Journal Article] Progression of Alcoholic and Non-alcoholic Steatohepatitis: Common Metabolic Aspects of Innate Immune System and Oxidative Stress2011

    • Author(s)
      Sakaguchi S, Takahashi S, Sasaki T, Kumagai T, Nagata K
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 26 Issue: 1 Pages: 30-46

    • DOI

      10.2133/dmpk.DMPK-10-RV-087

    • NAID

      130004463160

    • ISSN
      1347-4367, 1880-0920
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590173, KAKENHI-PROJECT-23790193
  • [Journal Article] Tumor necrosis factor-alpha-nuclear factor-kappa B-signaling enhances St2b2 expression during_12-O-tetradecanoylphorbol-13-acetate-ind uced epidermal hyperplasia2011

    • Author(s)
      Matsuda T, Shimada M, Sato A, Akase T, Yoshinari K, Nagata K, Yamazoe Y
    • Journal Title

      Biol Pharm Bull

      Volume: 34 Pages: 183-90

    • URL

      https://www.jstage.jst.go.jp/article/bpb/34/2/34_2_183/_article

    • Data Source
      KAKENHI-PROJECT-21590173
  • [Journal Article] Construction of a system that simultaneously evaluates CYP1A1 and CYP1A2 induction in a stable human-derived cell line using a dual reporter plasmid2010

    • Author(s)
      Sato W, Suzuki H, Sasaki T, Kumagai T, Sakaguchi S, Mizugaki M, Miyairi S, Yamazoe Y, Nagata K
    • Journal Title

      Drug Metab Pharmacokinet.

      Volume: 25 Pages: 180-189

    • URL

      https://www.jstage.jst.go.jp/article/dmpk/25/2/25_2_180/_article

    • Data Source
      KAKENHI-PROJECT-21590173
  • [Journal Article] Malondialdehyde-modified low density lipoprotein(MDA-LDL)-induced cell growth was suppressed by polycyclic aromatic hydrocarbons(PAHs)2010

    • Author(s)
      Suzuki H, Sasaki T, Kumagai T, Sakaguchi S, Nagata K
    • Journal Title

      J Toxicol Sci.

      Volume: 35 Pages: 137-147

    • URL

      https://www.jstage.jst.go.jp/article/jts/35/2/35_2_137/_article

    • Data Source
      KAKENHI-PROJECT-21590173
  • [Journal Article] Simultaneous expression of plural forms of human cytochrome P450 at desired ratios in HepG2 cells : adenovirus-mediated tool for cytochrome P450 reconstitution2009

    • Author(s)
      Aoyama K, Yoshinari K, Kim HJ, Nagata K, Yamazoe Y
    • Journal Title

      Drug Metab Pharmacokinet.

      Volume: 24 Pages: 209-217

    • URL

      https://www.jstage.jst.go.jp/article/dmpk/24/3/24_3_209/_article

    • Data Source
      KAKENHI-PROJECT-21590173
  • [Journal Article] Involvement of Vitamin D receptor in the intestinal induction of human ABCB12009

    • Author(s)
      Tachibana S, Yoshinari K, Chikada T, Toriyabe T, Nagata K, Yamazoe Y
    • Journal Title

      Drug Metab Dispos.

      Volume: 7 Pages: 1604-1610

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/19460946

    • Data Source
      KAKENHI-PROJECT-21590173
  • [Journal Article] Drug Metabolism Catalyzed by Cytochrome P4502009

    • Author(s)
      Nagata, K
    • Journal Title

      Folia Pharmacol. Jpn.

      Volume: 134 Pages: 146-148

    • NAID

      10025741531

    • URL

      https://www.jstage.jst.go.jp/article/fpj/134/3/134_3_146/_article

    • Data Source
      KAKENHI-PROJECT-21590173
  • [Journal Article] Unveiling a new essential cis-element for the transactivation of the CYP3A4 gene by xenobiotics2009

    • Author(s)
      Toriyabe T. Takada T. Aratsu Y. Matsubara T. Yoshinari Y. Nagata K. Yamazoe Y
    • Journal Title

      Mol Pharmacol.

      Volume: 75 Pages: 677-684

    • URL

      http://molpharm.aspetjournals.org/content/75/3/677.lon

    • Data Source
      KAKENHI-PROJECT-21590173
  • [Journal Article] Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7 : evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction2009

    • Author(s)
      Takeda S, Ishii Y, Iwanaga M, Nurrochmad A, Ito Y, Mackenzie PI, Nagata K, Yamazoe Y, Oguri K, Yamada H
    • Journal Title

      Mol Pharmacol

      Volume: 75 Pages: 956-964

    • URL

      http://molpharm.aspetjournals.org/content/75/4/956.long

    • Data Source
      KAKENHI-PROJECT-21590173
  • [Journal Article] Chenodeoxycholic acid-mediated activation of the famesoid X receptor negatively regulates hydroxysteroid sulfotransferase2006

    • Author(s)
      M.Miyata, Y.Matsuda, H.Tsuchiya, H.Kitada, T.Akase, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe
    • Journal Title

      Drug Metab Pharmacokin. 21

      Pages: 322-330

    • Data Source
      KAKENHI-PROJECT-17590114
  • [Journal Article] Role for enhanced fecal excretion of bile acid, in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity2006

    • Author(s)
      M.Miyata, H.Watase, W.Hori, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe
    • Journal Title

      Xenobiotica 36

      Pages: 631-644

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590114
  • [Journal Article] Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.2006

    • Author(s)
      M.Miyata, Y.Matsuda, H.Tsuchiya, H.Kitada, T.Akase, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe.
    • Journal Title

      Drug Metab. Pharmacokin 21

      Pages: 322-330

    • NAID

      10018042954

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590114
  • [Journal Article] Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase2006

    • Author(s)
      M.Miyata, Y.Matsuda, H.Tsuchiya, H.Kitada, T.Akase, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe
    • Journal Title

      Drug Metab. Pharmacokin 21

      Pages: 322-330

    • NAID

      10018042954

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590114
  • [Journal Article] Role for enhanced fecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity2006

    • Author(s)
      M.Miyata, H.Watase, W.Hori, M.Shimada, K.Nagata, F.J.Gonzalez, Y.Yamazoe
    • Journal Title

      Xenobiotica 36

      Pages: 631-644

    • Data Source
      KAKENHI-PROJECT-17590114
  • [Journal Article] Yamazoe Role for enhanced fecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity2006

    • Author(s)
      M.Miyata, H.Watase, W.Hori, M.Shimada, K.Nagata, F.J.Gonzalez, Y.
    • Journal Title

      Xenobiotica 36

      Pages: 631-644

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590114
  • [Journal Article] Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids : a mechanism for protection against cholic acid-induced liver toxicity.2005

    • Author(s)
      M.Miyata, A.Tozawa, H.Otsuka, T.Nakamura, K.Nagata, F.J.Gonzalez, Y.Yamazoe
    • Journal Title

      J.Pharmacol.Exp.Ther. 312

      Pages: 759-766

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390043
  • [Journal Article] Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity.2003

    • Author(s)
      H.Kitada, M.Miyata, T.Nakamura, A.Tozawa, W.Honma, M.Shimada, K.Nagata, C.J.Sinai, G.L.Guo, F.J.Gonzalez, Y.Yamazoe
    • Journal Title

      J.Biol.Chem. 278

      Pages: 17838-17844

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390043
  • [Presentation] CYP26A1遺伝子レポーターを用いたアゾール系化合物によるレチノイン酸の濃度変動の測定2017

    • Author(s)
      進藤佐和子、塩谷安奈里、渡辺美智子、佐々木崇光、熊谷健、永田清
    • Organizer
      第44回日本毒性学会学術年会(横浜)
    • Data Source
      KAKENHI-PROJECT-17K08419
  • [Presentation] CYP3A4遺伝子の新規転写活性化について2017

    • Author(s)
      渡辺考樹、小田桐玲王、荒津祐輔、佐々木崇光、進藤佐和子、熊谷健、永田清
    • Organizer
      フォーラム2017衛生薬学・環境トキシコロジー(仙台)
    • Data Source
      KAKENHI-PROJECT-17K08419
  • [Presentation] レチノイン酸の低濃度測定可能なCYP26A1遺伝子レポーターアッセイ系の構築2017

    • Author(s)
      森謙太、鈴木裕之、塩谷安奈里、佐々木崇光、進藤佐和子、熊谷健、永田清
    • Organizer
      フォーラム2017衛生薬学・環境トキシコロジー(仙台)
    • Data Source
      KAKENHI-PROJECT-17K08419
  • [Presentation] CYP遺伝子発現作用に及ぼす健康食品の影響2017

    • Author(s)
      渡邉夢実、熊谷健、佐々木崇光、永田清
    • Organizer
      フォーラム2017衛生薬学・環境トキシコロジー(仙台)
    • Data Source
      KAKENHI-PROJECT-17K08419
  • [Presentation] CYP3A4遺伝子の基本的転写活性化に関わる新規シスエレメントの探索2016

    • Author(s)
      小田桐玲生、佐々木崇光、熊谷健、永田清
    • Organizer
      平成28年度内外環境応答・代謝酵素研究会
    • Place of Presentation
      静岡
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] 健康食品による薬物代謝P450活性阻害の網羅的評価2016

    • Author(s)
      永田清、佐藤裕、熊谷健、佐々木崇光
    • Organizer
      フォーラム2016衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京
    • Year and Date
      2016-09-10
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] ヒト肝P450発現模倣細胞を利用した薬物代謝活性評価系の確立2016

    • Author(s)
      佐々木 崇光、佐藤 裕、熊谷 健、吉成 浩一、永田 清
    • Organizer
      第23回HAB研究機構学術年会
    • Place of Presentation
      つくば
    • Year and Date
      2016-06-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] CYP26A1レポーター遺伝子発現ウイルスを用いた低濃度下におけるレチノイン酸合成・代謝酵素活性阻害評価系の検討2016

    • Author(s)
      塩谷安奈里、渡邊美智子、渡辺郁実、角田駿哉、若生俊也、佐々木崇光、熊谷健、永田清
    • Organizer
      平成28年度内外環境応答・代謝酵素研究会
    • Place of Presentation
      静岡
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] 多環芳香族炭化水素によるCYP2D6発現誘導機構の解析2016

    • Author(s)
      稲見敬太、佐々木崇光、熊谷健、吉成浩一、永田清
    • Organizer
      平成28年度内外環境応答・代謝酵素研究会
    • Place of Presentation
      静岡
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] Activation of p38 MAPK by clotrimazole enhances the transctiption of human MRP3 through a novel transcriptional element2016

    • Author(s)
      Takamitsu Sasaki, Keita Inami, Takeshi Kumagai, Kouichi Yoshinari, Kiyoshi Nagata
    • Organizer
      11th International ISSX Meeting
    • Place of Presentation
      Busan
    • Year and Date
      2016-06-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] レチノイン酸代謝酵素CYP26の活性阻害評価系構築2015

    • Author(s)
      新井 悠、佐々木崇光、稲見敬太、佐藤 裕、熊谷 健、吉成浩一、永田 清
    • Organizer
      第54回日本薬学会東北支部大会
    • Place of Presentation
      岩手
    • Year and Date
      2015-09-26
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] Profiles of immune cells and reproduction of immune-mediated drug-induced injury2015

    • Author(s)
      Fujisaka Y, Kondo Y, Sasaki T, Kogure T, Inoue J, Nakagome Y, Wakui Y, Iwata T, Morosawa T, Umetu T, Suzuki H, Yamaguchi H, Mano N, Nagata K, Shimosegawa T
    • Organizer
      American College of Gastroenterology 2015 annual scientific meeting
    • Place of Presentation
      Honolulu
    • Year and Date
      2015-10-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] Construction of cell evaluation systems that mimic the P450 activity in human hepatocytes2015

    • Author(s)
      Sato Y, Sasaki T, Arai Y, Kumagai T, Nagata K
    • Organizer
      30 th, JSSX annual meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] レポーター遺伝子導入細胞株を用いた健康食品によるCYP1A1/1A2誘導の網羅的評価2015

    • Author(s)
      永田 清、佐々木崇光、熊谷 健
    • Organizer
      フォーラム2015 衛生薬学・環境トキシコロジー
    • Place of Presentation
      神戸
    • Year and Date
      2015-09-17
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] Profiles of immune in peripheral blood and reproduction of immune-mediated drug-induced injury in vitro2015

    • Author(s)
      Fujisaka Y, Kondo Y, Kogure T, Inoue J, Nakagome Y, Iwata T, Morosawa T, Umetu T, Suzuki H, Yamaguchi H, Sasaki T, Mano N, Nagata K, Shimosegawa T
    • Organizer
      第19回日本肝臓学会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] Protein-protein interaction of cytochrom P450 (CYP) 3A4 and UDP-glucuronosyltransferase (UGT) 1A7 in living cells: functional interaction and fluorescent resonance energy transfer (FRET) analysis2015

    • Author(s)
      Egoshi N, Kinoshita K, Koba H, Ikushiro S, Nagata K, Yamazoe Y, Peter IM, Yamada H, Ishii Y
    • Organizer
      30 th, JSSX annual meeting
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] 薬物代謝酵素発現細胞及び誘導評価細胞を用いた薬物性肝障害研究について2015

    • Author(s)
      佐々木崇光、熊谷 健、永田 清
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      金沢
    • Year and Date
      2015-06-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] サイクリン依存性キナーゼ1(Cdk1)がCYP2D6及びCYP3A4遺伝子発現に及ぼす影響の解析2015

    • Author(s)
      稲見敬太、佐々木崇光、中島菜月、小野 緑、熊谷 健、永田 清
    • Organizer
      平成27年度内外環境応答・代謝酵素研究会
    • Place of Presentation
      旭川
    • Year and Date
      2015-07-18
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] 板藍根含有成分のCYP1A1/1A2遺伝子発現誘導に及ぼすPXRの影響2014

    • Author(s)
      熊谷 健、清松孝行、佐々木崇光、永田 清
    • Organizer
      創薬研究センターシンポジウム
    • Place of Presentation
      東北薬科大学(宮城県仙台市)
    • Year and Date
      2014-06-14
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] AhRを介さない多環芳香族炭化水素によるCYP誘導機構の解明2014

    • Author(s)
      稲見敬太、佐々木崇光、菅野秀一、熊谷 健、永田 清
    • Organizer
      創薬研究センターシンポジウム
    • Place of Presentation
      東北薬科大学(宮城県仙台市)
    • Year and Date
      2014-06-14
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] アデノウイルスを用いた新規CYP3A4活性阻害実験系の開発と健康食品による薬物代謝活性阻害評価2014

    • Author(s)
      佐藤 裕、髙橋昌悟、佐々木崇光、熊谷 健、永田 清
    • Organizer
      創薬研究センターシンポジウム
    • Place of Presentation
      東北薬科大学(宮城県仙台市)
    • Year and Date
      2014-06-14
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] 多環芳香族炭化水素によるCYP2D6およびCYP3A4の発現調節機構の解析2013

    • Author(s)
      稲見敬太、佐々木崇光、熊谷 健、菅野秀一、永田 清
    • Organizer
      2013年度P450、UGT、SULT研究会
    • Place of Presentation
      宮崎
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] MRP3遺伝子発現誘導に関与するMAPK経路の解析2013

    • Author(s)
      稲見敬太、、佐々木崇光、沼田喜弘、船越広大、新井 悠、菅野秀一、熊谷 健、永田 清
    • Organizer
      創薬研究センターシンポジウム
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] CYP3A4遺伝子発現誘導に及ぼす健康食品の影響2013

    • Author(s)
      熊谷 健、中澤洋一、工藤裕太、齋藤雄大、竹屋里恵、笠原 彩、佐々木崇光、永田 清
    • Organizer
      フォーラム2013衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] Pharmacokinetic function of hepatocyte-like cells differentiated from human iPS cells2013

    • Author(s)
      Kondo Y, Iwao T, Ogihara R, Sasaki T, Nagata K, Kurose K, Horikawa T, Niwa T, Yamaori S, Ohmori S, Nakamura K, Matsunaga T
    • Organizer
      28th JSSX annual meeting
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] Cytochrome P450 3A4 restores the catalytic property of udp-glucuronosyltransferase 1A1*6, one of the allelic variants which are concerned for causing gilbert syndrome2013

    • Author(s)
      Kinoshita K, Oizaki T, Iwamoto Y, Nishimura Y, Miyauchi Y, Ikushiro S, Yamazoe Y, Nagata K, Mackenzie P, Yamada H, Ishii Y
    • Organizer
      28th JSSX annual meeting
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] CYP2D6活性阻害評価系の構築と健康食品の使用実態調査に基づいた薬物相互作用の解析2013

    • Author(s)
      佐々木瞳、佐々木崇光、稲見敬太、熊谷 健、永田 清
    • Organizer
      第23回日本医療薬学会年会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] Suppression of cytochrome p450 3A4 activity By UDP-glucuronosyltransferase 2B7: crucial role of the length of UGT2B7 cytosolic tail in the suppression2013

    • Author(s)
      Miyauchi Y, Nagata K, Yamazoe Y, Mackenzie P, Yamada H, Ishii Y
    • Organizer
      28th JSSX annual meeting
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] 肝分化iPS細胞へのLETF同時導入によるCYP3A4発現影響2013

    • Author(s)
      佐藤 裕、高橋昌悟、佐々木崇光、松永民秀、永田 清
    • Organizer
      2013年度P450、UGT、SULT研究会
    • Place of Presentation
      宮崎
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] Introduction of a N-glycosylation site to UDP-glucurosyltransferase 2B3 alters the sensitivity to cytochrome P450 3A1-dependent modulation2013

    • Author(s)
      Nakamura T, Miyauchi Y, Takeda T, Yamazoe Y, Nagata K, Mackenzie P, Yamada H, Ishii Y
    • Organizer
      28th JSSX annual meeting
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] ヒトiPS細胞由来肝細胞を用いた薬物代謝酵素誘導評価2013

    • Author(s)
      松永民秀、近藤祐樹、荻原留理、岩尾岳洋、永田 清、黒瀬光一、堀川隆司、丹波卓朗、山折 大、大森 栄、中村克徳
    • Organizer
      フォーラム2013衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] 健康食品である板藍根のCYP3A4発現誘導に及ぼす影響2013

    • Author(s)
      熊谷 健、菅原亮輔、三浦真知、佐々木崇光、宮入伸一、永田 清
    • Organizer
      創薬研究センターシンポジウム
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] 新規P450活性阻害実験系の開発と健康食品による薬物代謝活性阻害評価2013

    • Author(s)
      佐藤 裕、髙橋昌悟、石橋幸奈、根本あゆみ、齋藤詩奈子、角間元美、榊 聡美、伏見 彩、佐々木崇光、熊谷 健、永田 清
    • Organizer
      フォーラム2013衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] In vitroでの酸化ストレスモデルとしての鉄存在下actinomycin DによるTNF-α誘導肝細胞障害の構築とNOの影響2012

    • Author(s)
      Sakaguchi S, Miura A, Takahashi S, Sasaki T, Kumagai T, Nagata K
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-28
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] Identification of a novel transactivation region of the MRP3 gene2012

    • Author(s)
      Sasaki T, Numata Y, Narita M, Matsui S, Toriyabe T, Yamazoe Y, Nagata K
    • Organizer
      International Symposium on PPF Molecular Pharmacokinetics
    • Place of Presentation
      一橋記念講堂(東京都)
    • Year and Date
      2012-01-17
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] Tamihide Matsunaga : Effect of quercetin on differentiation into hepatocyte-like cells from human induced pluripotent stem cells2011

    • Author(s)
      Yuki Kondo, Takahiro Iwao, Masayoshi Saito, Takuro Niwa, Koichi Kurose, Kiyoshi Nagata
    • Organizer
      26^<th> JSSX Annual Meeting
    • Place of Presentation
      広島
    • Year and Date
      2011-11-29
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] Hepatocyte nuclear factor-6 enhances expression of CYP3A4 in HepG2 cells and hepatocyte-like cells differentiated from human induced pluripotent stem cells2011

    • Author(s)
      Takamitsu Sasaki, Yutaka Tanaka, Shogo Takahashi, Takeshi Kumagai, Shuhei Sakaguchi, Tamihide Matsunaga, Kiyoshi Nagata
    • Organizer
      26th JSSX Annual Meeting
    • Place of Presentation
      広島
    • Year and Date
      2011-11-28
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] iPS細胞を用いた肝分化誘導法の検討2011

    • Author(s)
      山田健太、佐々木崇光、高橋昌悟、松永民秀、永田清
    • Organizer
      第50回記念日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-29
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through human pregnane X receptor2011

    • Author(s)
      Kumagai T, Sugawara R, Miura M, Sasaki T, Miyairi S, Nagata K
    • Organizer
      第26回日本薬物動態学会年会
    • Place of Presentation
      広島
    • Year and Date
      2011-11-22
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] iPS細胞を用いた肝分化誘導法の検討2011

    • Author(s)
      山田健太、佐々木崇光、高橋昌悟、松永民秀、永田清
    • Organizer
      第50回日本薬学会東北支部大会
    • Place of Presentation
      東北薬科大学(仙台市)
    • Year and Date
      2011-10-30
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] 板藍根によるCYP3A4活性誘導の検討2011

    • Author(s)
      菅原亮輔、熊谷健、三浦真知、高橋昌悟、佐々木崇光、坂口修平、宮入伸一、永田清
    • Organizer
      第50回日本薬学会東北支部大会
    • Place of Presentation
      東北薬科大学(仙台市)
    • Year and Date
      2011-10-30
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] Hepatocyte nuclear factor-6 enhances expression of CYP3A4 in HepG2 cells and hepatooyte-like cells differentiated from human induced pluripotent stem cells2011

    • Author(s)
      Sasaki T, Tanaka Y, Takahashi S, Kumagai T, Sakaguchi S, Matsunaga T, Nagata K
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2011-11-16
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] 板藍根によるCYP3A4活性誘導の検討2011

    • Author(s)
      Sugawara R, Kumagai T, Miura M, Takahashi S, Sasaki T, Sakaguchi S, Miyairi S, Nagata K
    • Organizer
      第50回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-29
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] Indirubin, a compornent of Ban-Lan-Gen, activates CYP3A4 gene transcription through human pregnane X receptor2011

    • Author(s)
      Kumagai T, Sugawara R, Miura M, Sasaki T, Miyairi S, Nagata K
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2011-11-16
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] 凍結P450発現アデノウイルス感染細胞を用いた薬物代謝評価系の構築2011

    • Author(s)
      安藤寛美、佐藤裕、高橋昌悟、佐々木崇光、永田清
    • Organizer
      第50回日本薬学会東北支部大会
    • Place of Presentation
      東北薬科大学(仙台市)
    • Year and Date
      2011-10-30
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] Hapatocyte nuclear factor-6 enhances expression of CYP3A4 in HepG2 cells and hepatocyte-like cells differentiated from human induced pluripotent stem cells2011

    • Author(s)
      Sasaki T, Tanaka Y, Takahashi S, Kumagai T, Sakaguchi S, Matsunaga T, Nagata K
    • Organizer
      第26回日本薬物動態学会年会
    • Place of Presentation
      広島
    • Year and Date
      2011-11-22
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] Comparison of Catalytic Properties between UDP-Glucuonocyltransferase 1A7* 3, an Allelic Variant, and Its Wild-type 1A7* 12010

    • Author(s)
      Kobe H, Ishii Y, Nurrochmad A, Ikushiro S, Yamazoe Y, Nagata K, Mackenzie IP, Yamada H
    • Organizer
      25^<th> JSSX Annual Meeting In Tokyo
    • Place of Presentation
      Omiya
    • Year and Date
      2010-10-18
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] CYP3A4転写活性に影響を与えるFBS中誠分の同定2010

    • Author(s)
      福士素子、熊谷健、佐々木崇光、永田清
    • Organizer
      第49回日本薬学会東北支部大会
    • Place of Presentation
      福島
    • Year and Date
      2010-10-09
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] Protein-protein Association of cytochrome P450 and UDP-Glucuonocyltransferase : Its Relevance to Enzyme Function2010

    • Author(s)
      Ishii Y, Miyauchi Y, Koba H, Takeda S, Nagata K, Mackenzie IP, Yamazoe Y, Yamada H
    • Organizer
      25^<th> JSSX Annual Meeting In Tokyo
    • Place of Presentation
      Omiya
    • Year and Date
      2010-10-17
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] MRP3における新規転写誘導機構の解明2010

    • Author(s)
      沼田善弘、佐々木崇光、佐藤渉、松井怜美、鳥谷部貴洋, 山添康、永田清
    • Organizer
      第49回日本薬学会東北支部大会
    • Place of Presentation
      福島
    • Year and Date
      2010-10-09
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] HepG2細胞を用いたTNF-α誘導肝障害モデルの構築2009

    • Author(s)
      坂口修平, 鈴木祐之, 高橋昌悟, 高橋尚子, 永田清
    • Organizer
      日本築学会129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-29
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] Novel Transcriptional Activation of the CYP3A4 gene2009

    • Author(s)
      Kiyoshi Nagata
    • Organizer
      The 3^<rd> Asian Pacific Regional ISSX Meeting
    • Place of Presentation
      Bangkok. Thailand
    • Year and Date
      2009-05-10
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] Suppression Mechanism by Polycyclic Aromatic Carbons in Malondialdehyde-modilied Low-Density Lipoprotein-induced Cell Growth2009

    • Author(s)
      Hiroyuki Suzuki, Takeshi Kumagai, Kiyoshi Nagata
    • Organizer
      The 3^<rd> Asian Pacific Regional ISSX Meeting
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2009-05-10
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] CYP1A1, CYP1A2誘導スクリーニングのためのin vitro同時評価系の構築2009

    • Author(s)
      佐藤渉, 田中大, 佐々木崇光, 熊谷健, 宮入伸ー, 永田清
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] 多環芳香族炭化水素類によるCYP3A4転写活性化分子機構の解析2009

    • Author(s)
      庄司理恵, 熊谷健, 佐々木崇光, 鳥谷部貴祥, 山添康, 永田清
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] アデノウイルスベクターを用いた薬物代謝・毒性評価系の確立2009

    • Author(s)
      高僑昌悟, 福士栄子, 鈴木椅之, 佐々木崇光, 熊谷健, 山添康, 永田清
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21590173
  • [Presentation] A novel evaluation system for inhibition of CYP3A4 activity by dietary supplements.

    • Author(s)
      Sato Y, Takahashi S, Sasaki T, Kumagai T, Nagata K
    • Organizer
      19th North American ISSX Meeting and 29th JSSX Meeting
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2014-10-19 – 2014-10-23
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] Cyclin-dependent kinase 1 involved in regulation of CYP2D6 expression.

    • Author(s)
      Inami K, Sasaki T, Kanno S, Kumagai T, Nagata K
    • Organizer
      19th North American ISSX Meeting and 29th JSSX Meeting
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2014-10-19 – 2014-10-23
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] Effect of Ban-Lan-Gen on transactivation of the CYP1A1 and CYP1A2 genes A novel evaluation system for inhibition of CYP3A4 activity by dietary supplements

    • Author(s)
      Kumagai T, Kiyomatsu T , Sasaki T, Nagata K
    • Organizer
      19th North American ISSX Meeting and 29th JSSX Meeting
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2014-10-19 – 2014-10-23
    • Data Source
      KAKENHI-PROJECT-25460195
  • [Presentation] Suppression of cytochrome P450 3A4 actiivity by UDP-glucuronosyltaransferase (UGT) 2B7: The role of charged residue(s) in the cytosolic tail of UGT2B7

    • Author(s)
      Miyauchia Y, Ishiia Y, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H
    • Organizer
      19th North American ISSX Meeting and 29th JSSX Meeting
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2014-10-19 – 2014-10-23
    • Data Source
      KAKENHI-PROJECT-25460195
  • 1.  YAMAZOE Yasushi (00112699)
    # of Collaborated Projects: 14 results
    # of Collaborated Products: 2 results
  • 2.  KATO Ryuichi (40112685)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  MIYATA Masaaki (90239418)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 8 results
  • 4.  YAZUMORI Toshio (70182350)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  NAGATA Miki (10196488)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  OZAWA Shogo (20185581)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  DEGAWA Masakuni (50134002)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  Sasaki Takamitsu (20382674)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 40 results
  • 9.  MURAYAMA Norie (90219949)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  FURUKAWA Masayuki
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  Matsunaga Tamihide (40209581)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 12.  SUZUKI Shinya (40196829)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  YOSHIDA Makoto (90201011)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  OHASHI Kyoichi (20137714)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KAWANO Sumie (20175293)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  大森 栄 (70169069)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 17.  吉成 浩一 (60343399)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 18.  保坂 卓臣 (30611579)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  志津 怜太 (50803912)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  MIYADO Shinji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  FUJITA Masataka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KUMAGAI Hiromichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  TAINAKA Hitoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  FUKUDA Katsuyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  甲斐 文夫
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  鎌滝 哲也
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  中村 克徳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  山田 英之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  石井 祐次
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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