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Yamamoto Kazuhiko  山本 一彦

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YAMAMOTO Kazuhiko  山本 一彦

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Researcher Number 80191394
Other IDs
External Links
Affiliation (Current) 2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームディレクター
Affiliation (based on the past Project Information) *help 2020 – 2022: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー
2019: 東京大学, 医学部附属病院, 教授
2018 – 2019: 国立研究開発法人理化学研究所, 生命医科学研究センター, 副センター長
2001 – 2016: 東京大学, 医学部附属病院, 教授
2009: The University of Tokyo, 医学部・附属病院, 教授 … More
2007: the University of Tokyo, Faculty of Medicine, Professor
2007: 東大, 医学部附属病院, 教授
2006: University of Tokyo, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授
2005: 東京大学, 大学院医学研究科, 教授
2004: 国立大学法人東京大学, 大学院・医学系研究科, 教授
2003: 東京大学, 医学部・附属病院, 教授
1999 – 2001: University of Tokyo, Faculty of Medicine, Professor, 医学部・附属病院, 教授
2000: University of Tokyo, Hospital, Professor, 医学部付属病院, 教授
1999: 東京大学, 大学院・医学系研究科・医学部, 教授
1998: 東京大学, 医学部, 教授
1998: 東京大学, 医学部・附属病院・内科, 教授
1998: 東京大学, 医学部附属病院, 教授
1995 – 1997: Medical Institute of Bioregulation, Department of Clinical Immunology, Profesor, 生体防御医学研究所, 教授
1996: Medical Institute of Bioregulation Kyushu Univ.Professor & Chairman, 臨床免疫学, 教授
1996: Department of Internal Medicine, The University of Tokyo, Professor, 医学部・付属病院・内科, 教授
1995: 九州大学, 生体防御医学研究所・臨床免疫学, 教授
1993 – 1994: 聖マリアンナ医科大学, 難病治療研究センター, 助教授
1992: 東京大学, 医学部(病)物療内科, 講師
1991 – 1992: 東京大学, 医学部, 講師
1991: 東京大学, 医学部・(病)物療内科, 講師
1990: 東京大学, 保健管理センター・内科, 助手
1990: 東京大学, 医学部, 助手
1989: 東京大学, 保健管理センター, 助手 Less
Review Section/Research Field
Principal Investigator
内科学一般 / 膠原病・アレルギー・感染症内科学 / Biological Sciences / Broad Section I / Immunology
Except Principal Investigator
Biological Sciences / Respiratory organ internal medicine / Laboratory medicine / Immunology / Circulatory organs internal medicine / Respiratory organ internal medicine / Dermatology / 内科学一般
Keywords
Principal Investigator
T細胞レセプター / T細胞 / PCR / SSCP / T細胞クローン / ゲノム / T cell receptor / 免疫学 / 慢性関節リウマチ / T cells … More / rheumatoid arthritis / 関節リウマチ / 内科 / レトロウイルス / HIV / クロノタイプ / 自己抗体 / IL-10 / 免疫疾患 / T Cell / T Cell Receptor / 全身性エリテマトーデス / T cell clone / シトルリン / 遺伝子 / 生体分子 / 遺伝学 / 遺伝子治療 / リコンビナント抗原 / 自己抗原 / エピト-プ / cDNA / 自己免疫疾患 / エピゲノム解析 / オミックス / ホールトランスクリプトーム解析 / 一塩基多型 / 多因子性疾患 / クロマチンステイタス解析 / クロマチン構造解析 / eQTL解析 / マルチオミクス解析 / 遺伝子多型 / シングルセル解析 / オープンクロマチン解析 / エンハンサー / プロモーター / 遺伝子発現量 / エピゲノム / プロモーターエンハンサー解析 / 遺伝子発現量解析 / 疾患関連遺伝子多型 / 免疫細胞分画 / QTL解析 / 量的形質遺伝子座 / 疾患感受性遺伝子変異 / ゲノムワイド関連解析 / ヒト免疫 / 多因子疾患 / internal medicine / genetics / Immunology / エルゴチオネイン / サイトカイン / SLC22A4 / 有機カチオントランスポーター / 疾患関連遺伝子 / PAD4 / anti-citrullinated peptide antibody / citrulline / PAD4遺伝子 / 抗シトルリン抗体 / pathogenic T cell / epitope / autommune disease / 病態形成性T細胞 / エピトープ / 自己免疫 / gene transfer / T cell receptor clonality / Cytotoxic T cells / dendritic cells / Peyer's patch / Oral tolerance / 樹状細胞 / パイエル板 / 経口トレランス / cell therapy / gene transduction / antigen-specific immunotherapy / Immune diseases / レトロウィルス / リンパ球 / 免疫細胞療法 / 遺伝子導入 / 抗原特異的免疫療法 / systemic lupus erythematosus / antigen-specific T cells / Autoimmune diseases / 皮膚筋炎・多発筋炎 / 全身エリテマトーデス / 標的抗原 / 抗原特異的T細胞 / 全身性自己免疫疾患 / Collagen induced arthritis / コラーゲン誘導関節炎 / Systemic Lupus Erythematosus / Rheumatoid Arthritis / T cell / PADI4 / Bip / 細胞・組織 / 組織・細胞 / 臨床 / 病理学 / レトロウィルスベクター / 免疫制御 / NKT細胞 / SNP / 遺伝子不活化 / 脱メチル化 / メチル化 / 腫瘍免疫 / RCP / 遊走機能分子 / 好中球 / 分子生物学 … More
Except Principal Investigator
MMP / がん / T-cell receptor / dilated cardiomyopathy / myocarditis / 自己免疫疾患 / 自然免疫 / 気管支喘息 / ブレオマイシン / 肝細胞増殖因子 / ligand superfamily / TNF receptor / costimulatory molecule / immunotherapy / Takayasu Arteritis / MMP-9 / MMP-2 / 胃癌 / TIMP / 細胞外マトリックス / SSCP / RT-PCR / genomic transfer / colony formation / HTLV-I associated arthropathy / 炎症 / 自己免疫病 / 免疫制御 / T細胞 / アナジー / cell-mediated immunity / シグナル伝達 / 免疫病 / 炎症・がん / DAMP / 免疫原性核酸 / HMGB1 / 自然免疫受容体 / 恒常性維持 / 免疫シグナル伝達 / mouse model / hydroxyproline / airway remodeling / interleukin 10 / bronchial asthma / 遺伝子治療 / 樹状細胞 / 肺胞マクロファージ / TGF-β / 肺線維化 / ハイドロキシプロン / リモデリング / マウスモデル / ハイドロキシプロリン / 気道リモデリング / インターロイキン10 / regeneration, / autoimmune diseases / signal transduction / memory / recognition and diversity / thymus, bone marrow, lymph nodes / spatio-temporal regulation / immune surveillance / アレルギー / 感染症 / 免疫系の修復と強化 / 免疫監視システム / 免疫組織の修復と強化 / ワクチン / 免疫シグナル / 認識の多様性 / 免疫監視機構 / 危険シグナル / 胸腺、骨髄、リンパ組織 / 再生、修復 / 免疫記憶 / 抗原認識、多様性 / 胸腺、骨髄・二次リンパ節 / 時空間的制御 / 免疫監視 / Repair factor / Hepatocyte growth factor / Bronchial asthma / 肝細胞増殖因子(MGF) / 気道炎症 / 気管支上皮細胞 / 気道過敏性 / 動物モデル / 修復因子 / Repair / Pulmonary Fibrosis / Bleomycin / Transforming Growth Factor β-1 / Hepatocyte Growth Factor / 再生因子 / インターフェロンガンマ / TGEβ-1 / 修復 / 肺線維症 / TGFβ-1 / auto-antigen / arteritis / dilated cardimyopathy / Clinical Samples / Clinical Status / Merosin / Collagen / Telomelase / ECM / 筋ジストロフィー症 / 癌 / ODC / VEGF / エンドスタチン / 大腸癌 / 胆汁 / 臨床サンプル / 臨床病態 / メロシン / コラーゲン / テロメラーゼ / prognosis / gastric cancer / hepatocellular carcinoma / tumor marker / laminin / extracellular matrix / 予後因子 / 肝臓癌 / 腫瘍マーカー / ラミニン / Dermatophagoides pteronyssinus (Dp) / T cell receptor / T cell clone / atopic dermatitis / T細胞クロナリティー / アトピー性皮膚炎 / rheumatoid arthritis / retrovirus / loss of contact inhibition / proto oncogene / synovial hyperplasia / HTLVーI遺伝子導入マウス / tax遺伝子 / P40X / polymerase chain reaction / HAAP / HTLVーI / ATL / 滑膜病変 / HTLVー1 associated arthropathy / 足場非依存性増殖 / contact in hition loss / protooncogene / 滑膜増殖 / 自己免疫 / G蛋白 / 白血病 / 免疫老化 / 獲得免疫 / がん免疫 / 免疫組織 / 自己寛容 / 免疫病態 / 自己識別 / 免疫系自己 / 胸腺 / 自己認識 / 生体恒常性 / 免疫応答 / 生体防御 / メチル化 / 細胞増殖停止 / 抑制信号 / 増殖停止信号 / ras / 共刺激 / 細胞内信号伝達 / 制御刺激 / 制御機構 / 細胞周期遅延 / 免疫寛容 / 細胞周期 / 低反応性 / Btk / 自己抗原 / ケモカイン / 自己免疫症患 / 免疫不全症 / 免疫病の修復 / 粘膜免疫 / チロシンキナーゼ / サイトカイン / 免疫寛容の破綻 / 原発性免疫不全症 / 慢性炎症 Less
  • Research Projects

    (42 results)
  • Research Products

    (159 results)
  • Co-Researchers

    (73 People)
  •  Establishment of a novel strategy for pathological analysis of multifactorial diseases using genetic risk variantsPrincipal Investigator

    • Principal Investigator
      Yamamoto Kazuhiko
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section I
    • Research Institution
      Institute of Physical and Chemical Research
  •  Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders

    • Principal Investigator
      Taniguchi Tadatsugu
    • Project Period (FY)
      2015 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  Development of rheumatoid arthritis-directed human immunologyPrincipal Investigator

    • Principal Investigator
      YAMAMOTO KAZUHIKO
    • Project Period (FY)
      2011 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      The University of Tokyo
  •  関節リウマチにおける自己抗原とそれに対する免疫応答制御Principal Investigator

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      The University of Tokyo
  •  Pathological roles of a citrullinating enzyme PADI4 in rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      The University of Tokyo
  •  Mechanisms and their regulation of autoimmune disordersPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      2007 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Immunological Self Recognition and its Disorders

    • Principal Investigator
      MINATO Nagahiro
    • Project Period (FY)
      2007 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  生体防御と免疫病制御の統合的パラダイム

    • Principal Investigator
      MINATO Nagahiro
    • Project Period (FY)
      2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Kyoto University
  •  Analyses of a cation transporters during immune and inflammatory responsesPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      The University of Tokyo
  •  An experimental research on new therapy of bronchial asthma through modulation of dendritic cell functions by IL-10

    • Principal Investigator
      DOHI Makoto
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      The University of Tokyo
  •  Analyses on functional relationship of rheumatoid arthritis associated PADI4 gene and the pathogenesis.Principal Investigator

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      The University of Tokyo
  •  Immune Surveillance, Its cellular and molecular basis, regulation and maintenance

    • Principal Investigator
      WATANABE Takeshi
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      RIKEN
      Kyushu University
  •  Establishment of HIV-specific cytotoxic T cells via TCR gene cloning and gene transfer using in vivo informationPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tokyo
  •  Evidence against epitope spreading of T cells in autoimmune diseases.Principal Investigator

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  アナジー誘導反復抗原刺激における抗原受容体を介するT細胞増殖停止信号伝達機構

    • Principal Investigator
      三崎 義堅
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  免疫担当細胞を用いた免疫疾患特異的なゲノム上での転写活性化領域マッピングの試み

    • Principal Investigator
      SAWADA Tetsuji
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  生体内の情報に基づいたHIVウイルス特異的T細胞の試験管内再構築法の確立Principal Investigator

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  An experimental study on the control of bronchial asthma by a regenerating factor of bronchial epithelial cells

    • Principal Investigator
      DOHI Makoto
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      The University of Tokyo
  •  免疫担当細胞を用いた免疫疾患特異的なゲノム上での転写活性化領域マッピングの試みPrincipal Investigator

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  抗原特異的T細胞レセプターを導入したNKT細胞による抗原特異的免疫制御の可能性Principal Investigator

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  Establishment of antigen-specific regulatory T cell lines induced by oral tolerance and the application to immunotherapyPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  EXPERMENTEAL STUDY ON THE CDNTROL OF PULMONARY FIBROSIS BY ENHANCING HGF/c-MET SYSTEM

    • Principal Investigator
      TANAKA Ryoichi
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  免疫病とその修復

    • Principal Investigator
      高津 聖志
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  拡張型心筋症(慢性心筋炎)のモデル動物の作成と治療法開発への応用

    • Principal Investigator
      SEKO Yoshinori
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Establishment of antigen-specific immunotherapy with artificial lymphocytes genetically engineered by antigen specific receptor and functional genes.Principal Investigator

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  Development of the Specific Immunotherapy for Myocarditis, Dilated Cardiomyopathy(Chronic Myocarditis), and Takayasu Arteritis.

    • Principal Investigator
      SEKO Yoshinori
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Tokyo
  •  Establishment of Quantitative Method for Measurement of MMPs in Blood and Bile, and Its Clinical Application

    • Principal Investigator
      KUBOTA Shunichiro
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Laboratory medicine
    • Research Institution
      University of Tokyo
  •  Analyses of antigen-specific T cells in systemic types of autoimmune disorders.Principal Investigator

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  固形癌局所に浸潤、集積しているT細胞の抗原レセプター機能の試験管内再構築Principal Investigator

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  Establishment of laboratory method using the expression of extracellular matrix components as markers for diagnosis and prognosis of cancer and inflammatory diseases

    • Principal Investigator
      KUBOTA Shunichiro
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Laboratory medicine
    • Research Institution
      University of Tokyo
  •  Novel method to detect T clonality and the antigen specificityPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      KYUSHU UNIVERSITY
  •  免疫応答におけるT細胞レセプター・クロノタイプ検出システムの確立と免疫病への応用Principal Investigator

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  The accumulotion of T cell clonotypes in inooloed skin lesions of pationsts with atopic dermatitis

    • Principal Investigator
      MIZOGUCHI Masako
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      St.Marianna University School of Medicine
  •  Development of a laboratory examination system for T cell clonality analysis.Principal Investigator

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内科学一般
    • Research Institution
      KYUSHU UNIVERSITY
  •  Analyzes of accumulating T cell clonotypes in different joint lesions of rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Kazuhiko
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      Kyushu University
      St. Marianna University School of Medicine
  •  免疫応答におけるT細胞レセプター・クロノタイプ検出システムの確立と免疫病への応用Principal Investigator

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      St. Marianna University School of Medicine
  •  免疫応答におけるT細胞レセプター・クロノタイプ検出システムの確立と免疫病への応用Principal Investigator

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      St. Marianna University School of Medicine
  •  好中球遊走機能分子TM316の蛋白一次構造の決定と機能ドメインの検索Principal Investigator

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  自己免疫疾患における自己抗原反応性T細胞の分子生物学的解析Principal Investigator

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  自己抗体産生機序におけるエピト-プ・プログレッション現象の分子生物学的解析Principal Investigator

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  HTLV-I infection and immune disorders : A role of HTLV-I tax gene for mesenchymal cell transformation.

    • Principal Investigator
      NISHIOKA Kusuki
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      Rheumatology Division, Institute of Medical Science, St Marianna University
      Tokyo Women's Medical University
  •  自己抗体で認識される自己抗原分子上のエピト-プ領域の分子生物学的解析Principal Investigator

    • Principal Investigator
      山本 一彦
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Patent Other

  • [Journal Article] Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci2022

    • Author(s)
      Yamaguchi Kensuke、Ishigaki Kazuyoshi、Suzuki Akari、Tsuchida Yumi、Tsuchiya Haruka、Sumitomo Shuji、Nagafuchi Yasuo、Miya Fuyuki、Tsunoda Tatsuhiko、Shoda Hirofumi、Fujio Keishi、Yamamoto Kazuhiko、Kochi Yuta
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 4659-4659

    • DOI

      10.1038/s41467-022-32358-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-20K08800, KAKENHI-PROJECT-21K19501, KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K23860, KAKENHI-PROJECT-23K24373
  • [Journal Article] Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus2022

    • Author(s)
      Takeshima Yusuke、Iwasaki Yukiko、Nakano Masahiro、Narushima Yuta、Ota Mineto、Nagafuchi Yasuo、Sumitomo Shuji、Okamura Tomohisa、Elkon Keith、Ishigaki Kazuyoshi、Suzuki Akari、Kochi Yuta、Yamamoto Kazuhiko、Fujio Keishi
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: - Issue: 6 Pages: 845-853

    • DOI

      10.1136/annrheumdis-2021-221464

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02849, KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-21K19501
  • [Journal Article] Functional genomics of autoimmune diseases2021

    • Author(s)
      Suzuki Akari、Guerrini Matteo Maurizio、Yamamoto Kazuhiko
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 無 Issue: 6 Pages: 689-697

    • DOI

      10.1136/annrheumdis-2019-216794

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Journal Article] Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases2020

    • Author(s)
      Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Yamaji T, et al
    • Journal Title

      Nature Genetics

      Volume: 52 Issue: 7 Pages: 669-679

    • DOI

      10.1038/s41588-020-0640-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K10655, KAKENHI-PROJECT-20K07709, KAKENHI-PROJECT-20K08288, KAKENHI-PROJECT-16H02468, KAKENHI-PROJECT-18H02894, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-18H04053, KAKENHI-PROJECT-20H00543, KAKENHI-PROJECT-18H02688, KAKENHI-PROJECT-18H02931, KAKENHI-PROJECT-18H02932, KAKENHI-PROJECT-19H03559, KAKENHI-PROJECT-19H03881, KAKENHI-PROJECT-19K22525, KAKENHI-PROJECT-19K17962, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20H03695, KAKENHI-PROJECT-20H03943, KAKENHI-PROJECT-18H02940
  • [Journal Article] Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis2020

    • Author(s)
      Tsuchiya Haruka、Ota Mineto、Sumitomo Shuji、Ishigaki Kazuyoshi、Suzuki Akari、Sakata Toyonori、Tsuchida Yumi、Inui Hiroshi、Hirose Jun、Kochi Yuta、Kadono Yuho、Shirahige Katsuhiko、Tanaka Sakae、Yamamoto Kazuhiko、Fujio Keishi
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 80 Issue: 4 Pages: 440-450

    • DOI

      10.1136/annrheumdis-2020-218189

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K16275, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-18H02846
  • [Journal Article] Chromosomal alterations among age-related haematopoietic clones in Japan2020

    • Author(s)
      Terao Chikashi、Suzuki Akari、Momozawa Yukihide、Akiyama Masato、Ishigaki Kazuyoshi、Yamamoto Kazuhiko、Matsuda Koichi、Murakami Yoshinori、McCarroll Steven A.、Kubo Michiaki、Loh Po-Ru、Kamatani Yoichiro
    • Journal Title

      Nature

      Volume: 584 Issue: 7819 Pages: 130-135

    • DOI

      10.1038/s41586-020-2426-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-16H02676
  • [Journal Article] Linking of genetic risk variants to disease-specific gene expression via multi-omics studies in rheumatoid arthritis2019

    • Author(s)
      Suzuki Akari、Terao Chikashi、Yamamoto Kazuhiko
    • Journal Title

      Seminars in Arthritis and Rheumatism

      Volume: 49 Issue: 3 Pages: S49-S53

    • DOI

      10.1016/j.semarthrit.2019.09.007

    • Open Access
    • Data Source
      KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-16K08634
  • [Journal Article] Shared genetic factors and their causality in autoimmune diseases2019

    • Author(s)
      Yamamoto Kazuhiko、Okada Yukinori
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 78 Issue: 11 Pages: 1449-1451

    • DOI

      10.1136/annrheumdis-2019-215099

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Journal Article] Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis.2019

    • Author(s)
      Sakurai K, Dainichi T, Garcet S, Tsuchiya S, Yamamoto Y, Kitoh A, Honda T, Nomura T, Egawa G, Otsuka A, Nakajima S, Matsumoto R, Nakano Y, Otsuka M, Iwakura Y, Grinberg-Bleyer Y, Ghosh S, Sugimoto Y, Guttman-Yassky E, Krueger JG, Kabashima K.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 144(4) Issue: 4 Pages: 1036-1049

    • DOI

      10.1016/j.jaci.2019.06.019

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08748, KAKENHI-PROJECT-19K22503, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05905, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-17H03990, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-17K19655, KAKENHI-PROJECT-15H05790, KAKENHI-PROJECT-18K08295
  • [Journal Article] PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes2019

    • Author(s)
      Akizuki S, Ishigaki K, Kochi Y, Law SM, Matsuo K, Ohmura K, Suzuki A, Nakayama M, Iizuka Y, Koseki H, Ohara O, Hirata J, Kamatani Y, Matsuda F, Sumida T, Yamamoto K, Okada Y, Mimori T, Terao C.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 78 Issue: 4 Pages: 509-518

    • DOI

      10.1136/annrheumdis-2018-214116

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09966, KAKENHI-PROJECT-16K09891, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-18H02849
  • [Journal Article] Metabolism as a key regulator in the pathogenesis of systemic lupus erythematosus2019

    • Author(s)
      Takeshima Yusuke、Iwasaki Yukiko、Fujio Keishi、Yamamoto Kazuhiko
    • Journal Title

      Seminars in Arthritis and Rheumatism

      Volume: 48 Issue: 6 Pages: 1142-1145

    • DOI

      10.1016/j.semarthrit.2019.04.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H05787
  • [Journal Article] Identification of rare coding variants in TYK2 protective for rheumatoid arthritis in the Japanese population and their effects on cytokine signalling2019

    • Author(s)
      Motegi Tomoki、Kochi Yuta、Matsuda Koichi、Kubo Michiaki、Yamamoto Kazuhiko、Momozawa Yukihide
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 78 Issue: 8 Pages: 1062-1069

    • DOI

      10.1136/annrheumdis-2019-215062

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-18H02849
  • [Journal Article] CD4+CD25+LAG3+ T Cells With a Feature of Th17 Cells Associated With Systemic Lupus Erythematosus Disease Activity2019

    • Author(s)
      Kato Rika、Sumitomo Shuji、Tsuchida Yumi、Tsuchiya Haruka、Nakachi Shinichiro、Sakurai Keiichi、Hanata Norio、Nagafuchi Yasuo、Kubo Kanae、Tateishi Shoko、Kanda Hiroko、Okamura Tomohisa、Yamamoto Kazuhiko、Fujio Keishi
    • Journal Title

      Frontiers in Immunology

      Volume: 10 Pages: 1619-1619

    • DOI

      10.3389/fimmu.2019.01619

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-19H03697
  • [Journal Article] Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.2019

    • Author(s)
      Negishi H, Endo N, Nakajima Y, Nishiyama T, Tabunoki Y, Nishio J, Koshiba R, Matsuda A, Matsuki K, Okamura T, Negishi-Koga T, Ichinohe T, Takemura S, Ishiwata H, Iemura SI, Natsume T, Abe T, Kiyonari H, Doi T, Hangai S, Yanai H, Fujio K, Yamamoto K, Taniguchi T.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 116 Issue: 47 Pages: 23653-23661

    • DOI

      10.1073/pnas.1915326116

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07166, KAKENHI-PROJECT-18K07167, KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-17H04050
  • [Journal Article] IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors2019

    • Author(s)
      Amariuta Tiffany、Luo Yang、Gazal Steven、Davenport Emma E.、van de Geijn Bryce、Ishigaki Kazuyoshi、Westra Harm-Jan、Teslovich Nikola、Okada Yukinori、Yamamoto Kazuhiko、Price Alkes L.、Raychaudhuri Soumya
    • Journal Title

      The American Journal of Human Genetics

      Volume: 104 Issue: 5 Pages: 879-895

    • DOI

      10.1016/j.ajhg.2019.03.012

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Journal Article] NK Cells Control Tumor-Promoting Function of Neutrophils in Mice2018

    • Author(s)
      Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y
    • Journal Title

      Cancer Immunol Res

      Volume: 印刷中 Issue: 3 Pages: 348-357

    • DOI

      10.1158/2326-6066.cir-17-0204

    • NAID

      120006402039

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15K08902, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045
  • [Journal Article] A gene module associated with dysregulated TCR signaling pathways in CD4 + T cell subsets in rheumatoid arthritis2018

    • Author(s)
      Sumitomo Shuji、Nagafuchi Yasuo、Tsuchida Yumi、Tsuchiya Haruka、Ota Mineto、Ishigaki Kazuyoshi、Nakachi Shinichiro、Kato Rika、Sakurai Keiichi、Hanata Norio、Tateishi Shoko、Kanda Hiroko、Suzuki Akari、Kochi Yuta、Fujio Keishi、Yamamoto Kazuhiko
    • Journal Title

      Journal of Autoimmunity

      Volume: 89 Pages: 21-29

    • DOI

      10.1016/j.jaut.2017.11.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09972, KAKENHI-PROJECT-18H05285
  • [Journal Article] Genetics of rheumatoid arthritis: 2018 status2018

    • Author(s)
      Okada Yukinori、Eyre Stephen、Suzuki Akari、Kochi Yuta、Yamamoto Kazuhiko
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 78 Issue: 4 Pages: 446-453

    • DOI

      10.1136/annrheumdis-2018-213678

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08634, KAKENHI-PROJECT-18H05285
  • [Journal Article] Reduction of CD83 Expression on B Cells and the Genetic Basis for Rheumatoid Arthritis: Comment on the Article by Thalayasingam et al2018

    • Author(s)
      Tsuchida Yumi、Sumitomo Shuji、Ota Mineto、Tsuchiya Haruka、Nagafuchi Yasuo、Shoda Hirofumi、Fujio Keishi、Ishigaki Kazuyoshi、Yamaguchi Kensuke、Suzuki Akari、Kochi Yuta、Yamamoto Kazuhiko
    • Journal Title

      Arthritis & Rheumatology

      Volume: 70 Issue: 10 Pages: 1695-1696

    • DOI

      10.1002/art.40652

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09972, KAKENHI-PROJECT-18K16140, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H05285
  • [Journal Article] Overview of LAG-3-Expressing, IL-10-Producing Regulatory T Cells2017

    • Author(s)
      Fujio Keishi、Yamamoto Kazuhiko、Okamura Tomohisa
    • Journal Title

      Curr Top Microbiol Immunol

      Volume: 410 Pages: 29-45

    • DOI

      10.1007/82_2017_59

    • ISBN
      9783319689289, 9783319689296
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09918, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-16K15510
  • [Journal Article] Transforming Growth Factor-β3 Inhibits Antibody Production by Human B Cells.2017

    • Author(s)
      Tsuchida Y, Sumitomo S, Ishigaki K, Suzuki A, Kochi Y, Okamura T, Yamamoto K, Fujio K.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 1 Pages: 1-16

    • DOI

      10.1371/journal.pone.0169646

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-16K15510, KAKENHI-PROJECT-15H05787
  • [Journal Article] Identification of tonsillar CD4±CD25=LAG3± T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue.2017

    • Author(s)
      Sumitomo S, Nakachi S, Okamura T, Tsuchida Y, Kato R, Shoda H, Furukawa A, Kitahara N, Kondo K, Yamasoba T, Yamamoto K, Fujio K.
    • Journal Title

      Journal of autoimmunity.

      Volume: 76 Pages: 75-84

    • DOI

      10.1016/j.jaut.2016.09.005

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-16K15510
  • [Journal Article] Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis2017

    • Author(s)
      Nakachi Shinichiro、Sumitomo Shuji、Tsuchida Yumi、Tsuchiya Haruka、Kono Masanori、Kato Rika、Sakurai Keiichi、Hanata Norio、Nagafuchi Yasuo、Tateishi Shoko、Kanda Hiroko、Okamura Tomohisa、Yamamoto Kazuhiko、Fujio Keishi
    • Journal Title

      Arthritis Research & Therapy

      Volume: 19 Issue: 1 Pages: 1-11

    • DOI

      10.1186/s13075-017-1309-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09918, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-16K15510
  • [Journal Article] Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis2017

    • Author(s)
      Ishigaki Kazuyoshi、Kochi Yuta、Suzuki Akari、Tsuchida Yumi、Tsuchiya Haruka、Sumitomo Shuji、Yamaguchi Kensuke、Nagafuchi Yasuo、Nakachi Shinichiro、Kato Rika、Sakurai Keiichi、Shoda Hirofumi、Ikari Katsunori、Taniguchi Atsuo、Yamanaka Hisashi、Miya Fuyuki、Tsunoda Tatsuhiko、et al.、Yamamoto Kazuhiko
    • Journal Title

      Nature Genetics

      Volume: 49 Issue: 7 Pages: 1120-1125

    • DOI

      10.1038/ng.3885

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07211, KAKENHI-PROJECT-17K09972, KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15H04965, KAKENHI-PROJECT-15H05670
  • [Journal Article] Increased serum concentrations of IL-1 beta, IL-21 and Th17 cells in overweight patients with rheumatoid arthritis.2017

    • Author(s)
      Shoda, H., Nagafuchi, Y., Tsuchida, Y., Sakurai, K., Sumitomo, S., Fujio, K., and Yamamoto, K.
    • Journal Title

      Arthritis Res Ther.

      Volume: 19 Issue: 1 Pages: 111-111

    • DOI

      10.1186/s13075-017-1308-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05787
  • [Journal Article] Therapeutic potential of regulatory cytokines that target B cells.2016

    • Author(s)
      Fujio Keishi, Okamura Tomohisa, Sumitomo Shuji, Yamamoto Kazuhiko
    • Journal Title

      Internal Immunology

      Volume: 28 Issue: 4 Pages: 189-195

    • DOI

      10.1093/intimm/dxv069

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-16K15510
  • [Journal Article] 1.Immune responses to Mycobacterium heat shock protein 70 accompany self-reactivity to human BiP in rheumatoid arthritis2016

    • Author(s)
      Shoda H, Hanata N, Sumitomo S, Okamura T, Fujio K, Yamamoto K
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 22486-22486

    • DOI

      10.1038/srep22486

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461462, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-25461493
  • [Journal Article] Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells.2016

    • Author(s)
      Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N.
    • Journal Title

      J Biol Chem.

      Volume: 291 Issue: 34 Pages: 17629-38

    • DOI

      10.1074/jbc.m116.741256

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-16K15271
  • [Journal Article] Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.2016

    • Author(s)
      Morita K, Okamura T, Inoue M, Komai T, Teruya S, Iwasaki Y, Sumitomo S, Shoda H, Yamamoto K, Fujio K.
    • Journal Title

      Proc. Natl. Acad. Sci. U S A.

      Volume: 113 Issue: 50 Pages: 8131-8140

    • DOI

      10.1073/pnas.1611286114

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-16K09918
  • [Journal Article] Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity.2016

    • Author(s)
      Ban T., Sato G.R., Nishiyama A., Akiyama A., Takasuna M., Umehara M., Suzuki S., Ichino M., Matsunaga S., Kimura A., Kimura Y., Yanai H., Miyashita S., Kuromitsu J., Tsukahara K., Yoshimatsu K., Endo I., Yamamoto T., Hirano H., Ryo A., Taniguchi T., Tamura T.
    • Journal Title

      Immunity

      Volume: 45 Issue: 2 Pages: 319-332

    • DOI

      10.1016/j.immuni.2016.07.015

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-16H07105, KAKENHI-PROJECT-26460373, KAKENHI-PROJECT-15K19028, KAKENHI-PROJECT-16K19161, KAKENHI-PROJECT-16H05230, KAKENHI-PLANNED-24118002, KAKENHI-PROJECT-15H04860
  • [Journal Article] A new T-cell activation mode for suboptimal doses of antigen under the full activation of T cells with different specificity.2015

    • Author(s)
      Shibuya M, Fujio K, Shoda H, Okamura T, Okamoto A, Sumitomo S, Yamamoto K.
    • Journal Title

      Europian Journal of Immunology

      Volume: in press Issue: 6 Pages: 1643-53

    • DOI

      10.1002/eji.201444965

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-23229007
  • [Journal Article] Autoantigen BiP-derived HLA-DR4 epitopes differentially recognized by effector and regulatory T cells in rheumatoid arthritis.2015

    • Author(s)
      Shoda H, Fujio K, Sakurai K, Ishigaki K, Nagafuchi Y, Shibuya M, Sumitomo S, Okamura T, Yamamoto K
    • Journal Title

      Arthritis and Rheumatology

      Volume: in press Issue: 5 Pages: 1171-81

    • DOI

      10.1002/art.39054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-26461462
  • [Journal Article] Role of TGF-β3 in the regulation of immune responses2015

    • Author(s)
      Okamura T, Morita K, Iwasaki Y, Inoue M, Komai T, Fujio K, Yamamoto K
    • Journal Title

      Clin Exp Rheumatol

      Volume: 33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Journal Article] Interleukin-27 in T cell immunity.2015

    • Author(s)
      Iwasaki Y, Fujio K, Okamura T, Yamamoto K
    • Journal Title

      Int J Mol Sci

      Volume: 16 Issue: 2 Pages: 2851-63

    • DOI

      10.3390/ijms16022851

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25860803
  • [Journal Article] Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model2015

    • Author(s)
      Seri Y, Shoda H, Suzuki A, Matsumoto I, Sumida T, Fujio K, Yamamoto K
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 13041-13041

    • DOI

      10.1038/srep13041

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Journal Article] Genetics of rheumatoid arthritis in Asia-present and future.2015

    • Author(s)
      Yamamoto K, Okada Y, Suzuki A, Kochi Y.
    • Journal Title

      Nat Rev Rheumatol

      Volume: AOP Issue: 6 Pages: 375-379

    • DOI

      10.1038/nrrheum.2015.7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293225, KAKENHI-PROJECT-15H05787
  • [Journal Article] TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses2015

    • Author(s)
      Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K.
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 1-14

    • DOI

      10.1038/ncomms7329

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-13J04186, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25860803, KAKENHI-PROJECT-25860804, KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-15H05787
  • [Journal Article] Genetics of rheumatoid arthritis contributes to biology and drug discovery.2014

    • Author(s)
      Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, (省略), GARNET consortium, (以下省略).
    • Journal Title

      Nature

      Volume: 506 Issue: 7488 Pages: 376-381

    • DOI

      10.1038/nature12873

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22133008, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390360, KAKENHI-PROJECT-24592285, KAKENHI-PROJECT-25293225, KAKENHI-PROJECT-26460649, KAKENHI-PROJECT-221S0001
  • [Journal Article] The power Doppler twinkling artefact associated with periarticular calcification induced by intra-articular corticosteroid injection in patients with rheumatoid arthritis.2013

    • Author(s)
      Nagafuchi Y, Sumitomo S, Soroida Y, Kanzaki T, Iwasaki Y, Michishita K, Iwai T, Ikeda H, Fujio K, Yamamoto K.
    • Journal Title

      Ann Rheum Dis

      Volume: 72 Issue: 7 Pages: 1267-9

    • DOI

      10.1136/annrheumdis-2012-202897

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Journal Article] Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells2013

    • Author(s)
      Iwasaki, Y.
    • Journal Title

      Eur J Immunol

      Volume: undefined Issue: 4 Pages: 1063-73

    • DOI

      10.1002/eji.201242942

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590435, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23590343, KAKENHI-PROJECT-23659492, KAKENHI-PROJECT-23791106, KAKENHI-PLANNED-24118002, KAKENHI-PROJECT-24390246, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-24790990, KAKENHI-PROJECT-25460594, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25670459, KAKENHI-PROJECT-25860803
  • [Journal Article] Alendronate attenuates eosinophilic airway inflammation associated with suppression of Th2 cytokines, Th17 cytokines, and eotaxin-2.2013

    • Author(s)
      Oh Sasaki, Mitsuru Imamura, Yusuke Yamazumi, Hiroaki Harada, Taku Matsumoto, Katsuhide Okunishi, Kazuyuki Nakagome, Ryoichi Tanaka, Tetsu Akiyama, Kazuhiko Yamamoto and Makoto Dohi
    • Journal Title

      J. Immunol

      Volume: 191 Issue: 6 Pages: 2879-2889

    • DOI

      10.4049/jimmunol.1300460

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24890035, KAKENHI-PROJECT-25670138
  • [Journal Article] Transcription factor early growth response 3 is associated with the TGF-β1 expression and the regulatory activity of CD4-positive T cells in vivo.2013

    • Author(s)
      Sumitomo S, Fujio K, Okamura T, Morita K, Ishigaki K, Suzukawa K, Kanaya K, Kondo K, Yamasoba T, Furukawa A, Kitahara N, Shoda H, Shibuya M, Okamoto A, Yamamoto K.
    • Journal Title

      J Immunol

      Volume: 191 Issue: 5 Pages: 2351-9

    • DOI

      10.4049/jimmunol.1202106

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-24790990, KAKENHI-PROJECT-25461470, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25670459, KAKENHI-PROJECT-25860804
  • [Journal Article] PAD4 regulates proliferation of multipotent hematopoietic cells by controlling c-myc expression.2013

    • Author(s)
      Nakashima K, Arai1 S, Suzuki A, Nariai Y, Urano T, Nakayama M, Ohara O, Yamamura K, Yamamoto K, Miyazaki T.
    • Journal Title

      Nature Communications.

      Volume: 4 Issue: 1 Pages: 1836-1836

    • DOI

      10.1038/ncomms2862

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23791107, KAKENHI-PROJECT-25461494, KAKENHI-PROJECT-221S0001
  • [Journal Article] An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes.2013

    • Author(s)
      Shimane K, Kochi Y, Suzuki A, Okada Y, Ishii T, Horita T, Saito K, Okamoto A, Nishimoto N, Myouzen K, Kubo M, Hirakata M, Sumida T, Takasaki Y, Yamada R, Nakamura Y, Kamatani N, Yamamoto K.
    • Journal Title

      Rheumatology (Oxford)

      Volume: 52 Issue: 7 Pages: 1172-82

    • DOI

      10.1093/rheumatology/kes427

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24591436, KAKENHI-PROJECT-25461470
  • [Journal Article] Regulatory cell subsets in the control of autoantibody production related to systemic autoimmunity.2013

    • Author(s)
      Fujio K, Okamura T, Sumitomo S, Yamamoto K.
    • Journal Title

      Ann Rheum Dis

      Volume: 72 Pages: 1-8

    • DOI

      10.1136/annrheumdis-2012-202341

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23791106, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25670459
  • [Journal Article] Egr2 and Egr3 are the unique regulators for systemic autoimmunity.2013

    • Author(s)
      Sumitomo S, Fujio K, Okamura T, Yamamoto K.
    • Journal Title

      JAKSTAT

      Volume: 2 Issue: 2 Pages: e23952-e23952

    • DOI

      10.4161/jkst.23952

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25670459, KAKENHI-PROJECT-25860804
  • [Journal Article] A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese2012

    • Author(s)
      岡田随象
    • Journal Title

      PLoS Genetics

      Volume: (掲載確定) Issue: 1 Pages: 1002455-1002455

    • DOI

      10.1371/journal.pgen.1002455

    • NAID

      120005906866

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J00226, KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-20689029, KAKENHI-PROJECT-21390299, KAKENHI-PROJECT-21591258, KAKENHI-PROJECT-21591277, KAKENHI-PLANNED-22021023, KAKENHI-PLANNED-22116010, KAKENHI-PROJECT-22591074, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23590379, KAKENHI-PROJECT-23689051, KAKENHI-PROJECT-24591436
  • [Journal Article] Regulation of histone modification and chromatin structure by the p53-PADI4 pathway2012

    • Author(s)
      Tanikawa C, Espinosa M, Suzuki A, Masuda K, Yamamoto K, Tsuchiya E, Ueda K, Daigo Y, Nakamura Y, Matsuda K.
    • Journal Title

      Nat Commun.

      Volume: 3 Issue: 1 Pages: 676-676

    • DOI

      10.1038/ncomms1676

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-22300335, KAKENHI-PROJECT-22680064, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23650624, KAKENHI-PROJECT-23710316, KAKENHI-PROJECT-221S0001
  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.
    • Journal Title

      Nat Genet.

      Volume: (in press) Issue: 5 Pages: 511-6

    • DOI

      10.1038/ng.2231

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-20689029, KAKENHI-PROJECT-21591264, KAKENHI-PLANNED-22133008, KAKENHI-PROJECT-22710191, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23689051, KAKENHI-PROJECT-24390360, KAKENHI-PROJECT-24591679, KAKENHI-PROJECT-24592285, KAKENHI-PROJECT-24659274, KAKENHI-PROJECT-221S0002, KAKENHI-PLANNED-22116010, KAKENHI-ORGANIZER-22133001
  • [Journal Article] PADI4 polymorphism predisposes male smokers to rheumatoid arthritis.2011

    • Author(s)
      Kochi Y, Thabet MM, Suzuki A, Okada Y, Daha NA, Toes REM, Huizinga TWJ, Myouzen K, Kubo M, Yamada R, Nakamura Y, Yamamoto K.
    • Journal Title

      Ann Rheum Dis 70

      Pages: 512-515

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] PAD14 polymorphism predisposes male smokers to rheumatoid arthrilis.2011

    • Author(s)
      Kochi Y, Thabet MM, Suzuki A, Okada Y, Daha NA, Toes REM, Huizinga TWJ, Myouzen K, Kubo M, Yamada R, Nakamura Y, Yamamoto K
    • Journal Title

      Ann Rheum Dis

      Volume: 70 Pages: 512-515

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.2011

    • Author(s)
      Yukinori Okada, Tomomitsu Hirota, Yoichiro Kamatani, Atsushi Takahashi, Koichi Matsuda, Tatsuhiko Tsunoda, Toshihiro Tanaka, Michiaki Kubo, Yusuke Nakamura, Mayumi Tamari, Kazuhiko Yamamoto, Naoyuki Kamatani.
    • Journal Title

      PLos Genetics. in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] PADI4 polymorphism predisposes male smokers to rheumatoid arthritis.2011

    • Author(s)
      Kochi Y, Thabet MM, Suzuki A, Okada Y, Daha NA, Toes REM, Huizinga TWJ, Myouzen K, Kubo M, Yamada R, Nakamura Y, Yamamoto K.
    • Journal Title

      Ann Rheum Dis

      Volume: 70 Pages: 512-515

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] PADI4 polymorphism predisposes male smokers to rheumatoid arthritis2011

    • Author(s)
      Kochi Y, Thabet MM, Suzuki A, Okada Y, Daha NA, Toes REM, Huizinga TWJ, Myouzen K, Kubo M, Yamada R, Nakamura Y, Yamamoto K.
    • Journal Title

      Ann Rheum Dis

      Volume: 70 Issue: 3 Pages: 512-5

    • DOI

      10.1136/ard.2010.130526

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-23229007
  • [Journal Article] Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis.2011

    • Author(s)
      Shoda H, Fujio K, Shibuya M, Okamura T, Sumitomo S, Okamoto A, Sawada T, Yamamoto K.
    • Journal Title

      Arthritis Res Ther.

      Volume: 13

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-19059009
  • [Journal Article] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.2010

    • Author(s)
      Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N, Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K.
    • Journal Title

      Nat Genet.

      Volume: 42 Pages: 515-519

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Ethnogenetic heterogeneity of rheumatoid arthritis-implications for pathogenesis.2010

    • Author(s)
      Kochi Y, Suzuki A, Yamada R, Yamamoto K.
    • Journal Title

      Nat Rev Rheumatol. 6

      Pages: 290-295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.2010

    • Author(s)
      Kochi Y, Okada Y, Suzuki A, Ikari K, Taco C, Takahashi A, Yamazeld K, Hosono N, Myouzen K, Tsunoda T, Kama tani N, Funrichi T, Ikegawa S, Ohmura K, Munori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamum Y, Yamamoto K
    • Journal Title

      Nat Genet

      Volume: 42 Pages: 515-519

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] The family of IL-10 secreting CD4+ T cells.2010

    • Author(s)
      Fujio K, Okamura T, Yamamoto K
    • Journal Title

      Advances in Immunology.

      Volume: 105 Pages: 99-130

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] The family of IL-10 secreting CD4+T cells.2010

    • Author(s)
      Fujio K, Okamura T, Yamamoto K.
    • Journal Title

      Advances in Immunology. 105

      Pages: 99-130

    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population2010

    • Author(s)
      Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K.
    • Journal Title

      Arthritis Rheum.

      Volume: 62 Issue: 2 Pages: 574-9

    • DOI

      10.1002/art.27190

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility2010

    • Author(s)
      Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N, Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K.
    • Journal Title

      Nat Genet.

      Volume: 42 Issue: 6 Pages: 515-9

    • DOI

      10.1038/ng.583

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] The family of IL-10 secreting CD4+ T cells2010

    • Author(s)
      Fujio K, Okamura T, Yamamoto K.
    • Journal Title

      Advances in Immunology

      Volume: 05 Pages: 99-130

    • DOI

      10.1016/s0065-2776(10)05004-2

    • ISBN
      9780123813022
    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] The family of IL-10 secreting CD4+ T cells.2010

    • Author(s)
      Fujio K, Okamura T, Yamamoto K.
    • Journal Title

      Advances in Immunology.

      Volume: 105 Pages: 99-130

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population.2010

    • Author(s)
      Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K.
    • Journal Title

      Arthritis Rheum. 62

      Pages: 574-579

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus.2010

    • Author(s)
      Myouzen K, Kochi Y, Shimane K, Fujio K, Okamura T, Okada Y, Suzuki A, Atsumi T, Ito S, Takada K, Mimori A, Ikegawa S, Yamada R, Nakamura Y, Yamamoto K.
    • Journal Title

      Hum Mol Genet. 19

      Pages: 2313-2320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.2010

    • Author(s)
      Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A, Yamazaki K, Hosono N, Myouzen K, Tsunoda T, Kamatani N, Furuichi T, Ikegawa S, Ohmura K, Mimori T, Matsuda F, Iwamoto T, Momohara S, Yamanaka H, Yamada R, Kubo M, Nakamura Y, Yamamoto K.
    • Journal Title

      Nat Genet. 42

      Pages: 515-519

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] HLA-DRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in Japanese patients with rheumatoid arthritis.2010

    • Author(s)
      Okada Y, Suzuki A, Yamada R, Kochi Y, Shimane K, Myouzen K, Kubo M, Nakamura Y, Yamamoto K.
    • Journal Title

      Ann Rheum Dis. 69

      Pages: 1569-1570

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population.2010

    • Author(s)
      Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K.
    • Journal Title

      Arthritis Rheum. 62

      Pages: 574-579

    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count.2010

    • Author(s)
      Okada Y, Kamatani Y, Takahashi A, Matsuda K, Hosono N, Ohmiya H, Daigo Y, Yamamoto K, Kubo M, Nakamura Y, Kamatani N.
    • Journal Title

      Hum Mol Genet. 19

      Pages: 2079-2085

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAI P3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population2010

    • Author(s)
      Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K.
    • Journal Title

      Arthritis Rheum 62

      Pages: 574-79

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.2009

    • Author(s)
      Kochi Y, Myouzen K, Yamada R, Suzuki A, Kurosaki T, Nakamura Y, Yamamoto K.
    • Journal Title

      J Immunol. 183

      Pages: 5502-10

    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1.2009

    • Author(s)
      Okada Y, Yamada R, Suzuki A, Kochi Y, Shimane K, Myouzen K, Kubo M, Nakamura Y, Yamamoto K.
    • Journal Title

      Arthritis Rheum. 60

      Pages: 3582-3590

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population.2009

    • Author(s)
      Shimane K, Kochi Y, Yamada R, Okada Y, Suzuki A, Miyatake A, Kubo M, Nakamura Y, Yamamoto K.
    • Journal Title

      Ann Rheum Dis. 68

      Pages: 377-83

    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Genetics of rheumatoid arthritis: underlying evidence of ethnic differences.2009

    • Author(s)
      Kochi Y, Suzuki A, Yamada R, Yamamoto K.
    • Journal Title

      J Autoimmun. 32

      Pages: 158-162

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population2009

    • Author(s)
      Shimane K, Kochi Y, Yamada R, Okada Y, Suzuki A, Miyatake A, Kubo M, Nakamura Y, Yamamoto K.
    • Journal Title

      Ann Rheum Dis.

      Volume: 68 Issue: 3 Pages: 377-83

    • DOI

      10.1136/ard.2007.085704

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.2009

    • Author(s)
      Kochi Y, Myouzen K, Yamada R, Suzuki A, Kurosaki T, Nakamura Y, Yamamoto K.
    • Journal Title

      J Immunol. 183

      Pages: 5502-5510

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2.2009

    • Author(s)
      Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K.
    • Journal Title

      Proc Natl Acad Sci USA. 106

      Pages: 13974-79

    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1.2009

    • Author(s)
      Okada Y, Yamada R, Suzuki A, Kochi Y, Shimane K, Myouzen K, Kubo M, Nakamura Y, Yamamoto K.
    • Journal Title

      Arthritis Rheum. 60

      Pages: 3582-3590

    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2.2009

    • Author(s)
      Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K.
    • Journal Title

      Proc Natl Acad Sci USA. 106

      Pages: 13974-13979

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population2009

    • Author(s)
      Shimane K, Kochi Y, Yamada R, Okada Y, Suzuki A, Miyatake A, Kubo M, Nakamura Y, Yamamoto K.
    • Journal Title

      Ann Rheum Dis 68

      Pages: 377-83

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population.2009

    • Author(s)
      Shimane K, Kochi Y, Yamada R, Okada Y, Suzuki A, Miyatake A, Kubo M, Nakamura Y, Yamamoto K.
    • Journal Title

      Ann Rheum Dis. 68

      Pages: 377-383

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] Functional SNPs in CD244 gene increase the risk of rheumatoid arthritis in a Japanese population2008

    • Author(s)
      Suzuki A,Yamada R, Kochi Y, Sawada T, Okada Y, Matsuda K, Kamatani Y, Mori M, Shimane K, Takahashi A, Tsunoda T, Miyatake A, Kubo M, Kamatani N, Nakamura Y, Yamamoto K
    • Journal Title

      Nat Genet.

      Volume: 40 Pages: 1224-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] SLC22A4 polymorphism and rheumatoid arthritis susceptibility : a replication study in a Japanese population and a metaanalysis.2008

    • Author(s)
      Okada Y, Mori M, Yamada R, Suzuki A, Kobayashi K, Kubo M, Nakamura Y, Yamamoto K.
    • Journal Title

      J Rheumatol. 35

      Pages: 1723-1728

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice.2008

    • Author(s)
      Okamoto A, Fujio K, van Rooijen N, Tsuno NH, Takahashi K, Tsurui H, Hirose S, Elkon KB, Yamamoto K.
    • Journal Title

      J Immunol. 181

      Pages: 5264-5271

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] Functional SNPs in CD244 gene increase the risk of rheumatoid arthritis in a Japanese population.2008

    • Author(s)
      Suzuki A, Yamada R, Kochi Y, Sawada T, Okada Y, Matsuda K, Kamatani Y, Mori M, Shimane K, Takahashi A, Tsunoda T, Miyatake A, Kubo M, Kamatani N, Nakamura Y, Yamamoto K.
    • Journal Title

      Nat Genet. 40

      Pages: 1224-1229

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice.2008

    • Author(s)
      Okamoto A, Fujio K, van Rooijen N, Tsuno NH, Takahashi K, Tsurui H, Hirose S, Elkon KB, Yamamoto K.
    • Journal Title

      J Immunol. 181

      Pages: 5264-71

    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Functional SNPs in CD244 gene increase the risk of rheumatoid arthritis in a Japanese population.2008

    • Author(s)
      Suzuki A, Yamada R, Kochi Y, Sawada T, Okada Y, Matsuda K, Kamatani Y, Mori M, Shimane K, Takahashi A, Tsunoda T, Miyatake A, Kubo M, Kamatani N, Nakamura Y, Yamamoto K
    • Journal Title

      Nat Genet. 40

      Pages: 1224-9

    • Data Source
      KAKENHI-PROJECT-20390280
  • [Journal Article] Functional SNPs in CD244 gene increase the risk of rheumatoid arthritis in a Japanese population.2008

    • Author(s)
      Suzuki A, Yamada R, Kochi Y, Sawada T, Okada Y, Matsuda K, Kamatani Y, Mori M, Shimane K, Takahashi A, Tsunoda T, Miyatake A, Kubo M, Kamatani N, Nakamura Y, Yamamoto K
    • Journal Title

      Nat Genet. 40

      Pages: 1224-9

    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Lessons from a Genomewide Association Study of Rheumatoid Arthritis2007

    • Author(s)
      Yamamoto K, Yamada R.
    • Journal Title

      N. Engl. J. Med 357

      Pages: 1250-1251

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Lessons from a Genomewide Association Study of Rheumatoid Arthritis.2007

    • Author(s)
      Yamamoto K, Yamada R.
    • Journal Title

      N.Engl J.Med 357

      Pages: 1250-1251

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Interleukin-17B and interleukin-17C are associated with TNF-alpha Production and contribute to the exacerbation of inflammatory arthritis.2007

    • Author(s)
      Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Yamamoto K., 他2名
    • Journal Title

      J Immunol 179

      Pages: 7128-7136

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice.2007

    • Author(s)
      Okunishi K, Dohi M, Fujio K, Nakagome K, Yamamoto K., 他7名
    • Journal Title

      J. Immunol. 179

      Pages: 5504-5513

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Antigen-specific immunotherapy for autoimmune diseases.2007

    • Author(s)
      Yamamoto K.
    • Journal Title

      Expert Opin Biol Ther. 7

      Pages: 359-367

    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice2007

    • Author(s)
      Okunishi K, Dohi M, Fuiio K, Nakagome K, Tabata Y, Okasora T, Seki M, Shibuya M, Imamura M, Harada H, Tanaka R, Yamamoto K.
    • Journal Title

      J Immunol. 179

      Pages: 5504-5513

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Interleukin-17B and interleukin-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis2007

    • Author(s)
      Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Tsuno NH, Takahashi K, Yamamoto K.
    • Journal Title

      J Immunol. 179

      Pages: 128-136

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Interleukin-17B and interleukin-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis2007

    • Author(s)
      Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Yamamoto K., 他2名
    • Journal Title

      J Immunol 179

      Pages: 7128-7136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Hepatocyte growth factor significantly suppresses collagen-induced Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice arthritis in mice.2007

    • Author(s)
      Okunishi K, Dohi M, Fujio K, Nakagome K, Yamamoto K, 他7名
    • Journal Title

      J Immunol. 179

      Pages: 5504-5513

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Lessons from a Genomewide Association Study of Rheumatoid Arthritis.2007

    • Author(s)
      Yamamoto K, Yamada R.
    • Journal Title

      N. Engl. J. Med. 357

      Pages: 1250-1251

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Lessons from a Genomewide Association Study of Rheumatoid Arthritis.2007

    • Author(s)
      Yamamoto K, Yamada R.
    • Journal Title

      N. Engl. J. Med. 357

      Pages: 1250-1251

    • Data Source
      KAKENHI-PLANNED-19059005
  • [Journal Article] Antigen-specific immunotherapy for autoimmune diseases2007

    • Author(s)
      Yamamoto K, Okamoto A, Fuiio K.
    • Journal Title

      Expert Opin Biol Ther. 7

      Pages: 359-367

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice2007

    • Author(s)
      Okunjshi K, Dohi M, Fujio K, Nakagome K, Yamamoto K., 他7名
    • Journal Title

      J Immunol 179

      Pages: 5504-5513

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice2007

    • Author(s)
      Okunishi K, Dohi M, Fujio K, Nakagone K, Tabata Y, Okasora T, seki M, Shibuya M, Imamura M, Harada H, Tanaka R, Yamamoto K.
    • Journal Title

      J Immunol 179

      Pages: 5504-5513

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590782
  • [Journal Article] Prolonged allergen challenge in murine nasal allergic rhinitis : nasal airway remodeling and adaptation of nasal airway responsiveness2007

    • Author(s)
      Nakaya M, Dohi M, Okunishi K, Nakagome K, Tanaka R, Imamura M, Yamamoto K, Kaga K.
    • Journal Title

      Laryngoscope 117

      Pages: 881-885

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590782
  • [Journal Article] Lessons from a Genomewide Association Study of Rheumatoid Arthritis2007

    • Author(s)
      Yamamoto K, Yamada R.
    • Journal Title

      N. Engl. J. Med. 357

      Pages: 1250-1251

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Interleukin-17B and interleukin-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis.2007

    • Author(s)
      Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Yamamoto K., 他2名
    • Journal Title

      J. Immunol. 179

      Pages: 7128-7136

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] IL-5-induced hypereosinophilia suppresses the antigen-inudced immune response via a TGF-beta-dependent mechanism2007

    • Author(s)
      Nakagome K, Dohi M, Okunishi K, Tanaka R, Kouro R, Kano MR, Miyazono K, Miyazaki J, Takatsu K, Yamamoto K.
    • Journal Title

      J Immunol 179

      Pages: 284-294

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590782
  • [Journal Article] Idetification of citrullinated eukaryotic translation initiation factor 4G1 as novel autoantigen in rheumatoid in rheumatoid arthritis2006

    • Author(s)
      Okazaki Y, Suzuki A, Sawada T, Ohtake-Yamanaka M, Inoue T, Hasebe T, Yamada R, Yamamoto K.
    • Journal Title

      Biochem Biophys Res Commun 341

      Pages: 94-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Splenic dendritic cells induced by oral antigen administration are important for the transfer of oral tolerance in an experimental model of asthma2006

    • Author(s)
      Nagatani K, Dohi M, To Y, Tanaka R, Okunichi K, Nakagome K, Sagawa K. Tanno Y, Komagata Y, Yamamoto K.
    • Journal Title

      J Immunol. 176

      Pages: 1481-1489

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] The genetics of systemic lupus erythematosus : differences across ethnicities2006

    • Author(s)
      Kochi Y, Shimane K, Yamamoto K.
    • Journal Title

      APLAR J Rheumatology 9

      Pages: 353-358

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Antigen sensitized CD4^+CD62L^<low> memory/effector T helper 2 cells can induce airway hyperresponsiveness in an antigen free setting2006

    • Author(s)
      Nakagome K, Dohi M, Okunishi K, To Y, Sato A, Komagata Y, Nagatani K, Tanaka R, Yamamoto K.
    • Journal Title

      Respir Res. 28

      Pages: 6-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Idetification of citrullinated eukaryotic translation initiation factor 4G1 as novel autoantigen in rheumatoid in rheumatoid arthritis.2006

    • Author(s)
      Okazaki Y, Suzuki A, Sawada T, Ohtake-Yamanaka M, Inoue T, Hasebe T, Yamada R, Yamamoto K.
    • Journal Title

      Biochem Biophys Res Commun. 341

      Pages: 94-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390285
  • [Journal Article] In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-β in the lung2006

    • Author(s)
      Nakagome K, Dohi M, Okunishi K, Tanaka R, Miyazaki J, Yamamoto K.
    • Journal Title

      Thorax 61

      Pages: 886-894

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590782
  • [Journal Article] Noninvasive system for evaluating allergen-induced nasal hypersensitivity in murine allergic rhinitis2006

    • Author(s)
      Nakaya M, Dohi M, Okunishi K, Nakagome K, Tanaka R, Imamura M, Baba S, Takeuchi N, Yamamoto K, and Kimitaka K.
    • Journal Title

      Lab Invest 86

      Pages: 917-926

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590782
  • [Journal Article] Gene therapy of arthritis with TCR isolated from the inflamed paw2006

    • Author(s)
      Fuiio K, Okamoto A, Araki Y, Shoda H, Tahara, Tsuno NH, Takahashi K, Kitamura T, Yamamoto K.
    • Journal Title

      J Immunol. 177

      Pages: 8140-8147

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390287
  • [Journal Article] Splenic dendritic cells induced by oral antigen administration are important for the transfer of oral tolerance in an experimental model of asthma2006

    • Author(s)
      Nagatani K, Dohi M, Nakagone K, Tanaka R, To Y, Okunishi K, Komagata N, Yamamoto K.
    • Journal Title

      J Immunol 176

      Pages: 1401-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590782
  • [Journal Article] Anti-citrullinated collagen type I antibody is a target of autoimmunity in rheumatoid arthritis.2005

    • Author(s)
      Suzuki A, Yamada R, Ohtake-Yamanaka M, Okazaki Y, Sawada T, Yamamoto K.
    • Journal Title

      Biochem Biophys Res Commun. 333

      Pages: 418-426

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390285
  • [Journal Article] Localization of peptidylarginine deiminase 4(PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis.2005

    • Author(s)
      Chang X, Yamada R, Suzuki A, Sawada T, Yoshino S, Tokuhiro S, Yamamoto K.
    • Journal Title

      Rheumatology. 44

      Pages: 40-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390285
  • [Journal Article] A novel role of hepatocyte growth factor as an immune-regulator through suppressing dendritic cell functions2005

    • Author(s)
      Okunishi K, Dohi M, Nakagome K, Tanaka R, Mizuno S, Matsumoto K, Nakamura T, Miyazaki J, Yamamoto K.
    • Journal Title

      J Immunol 175

      Pages: 4745-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590782
  • [Journal Article] Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.2005

    • Author(s)
      Mori M, Yamada R, Kobayashi K, Kawaida R, Yamamoto K.
    • Journal Title

      J Hum Genet. 50

      Pages: 264-266

    • NAID

      10016131600

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390285
  • [Journal Article] Genome-wide single nucleotide polymorphism analyses of rheumatoid arthritis.2005

    • Author(s)
      Yamamoto K
    • Journal Title

      J Autoimmun. 25

      Pages: 12-15

    • Data Source
      KAKENHI-PROJECT-16390285
  • [Journal Article] Antigen-sensitized CD4+CD62+Llow memory/effector T helper 2 cells can induce airway hyperresponsiveness in an antigen-free setting2005

    • Author(s)
      Nakagome K, Dohi M, Okunishi K, To Y, Sato A, Komagata Y, Nagatani K, Tanaka R, Yamamoto K.
    • Journal Title

      Respir Res 28 ; 6(1)

      Pages: 46-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590782
  • [Journal Article] A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.2005

    • Author(s)
      Kochi Y, Yamada R, Suzuki A, Harley JB, Shirasawa S, Sawada T, Bae SC, Tokuhiro S, Chang X, Sekine A, Takahashi A, Tsunoda T, Ohnishi Y, Kaufman KM, Kang CP, Kang C, Otsubo S, Yumura W, Mimori A, Koike T, Nakamura Y, Sasazuki T, Yamamoto K.
    • Journal Title

      Nature Genet. 37

      Pages: 478-485

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390285
  • [Journal Article] A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.2005

    • Author(s)
      Kochi Y, Yamamoto K.他21名
    • Journal Title

      Nature Genetics 37

      Pages: 652-660

    • Data Source
      KAKENHI-PROJECT-15078101
  • [Journal Article] Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease.2004

    • Author(s)
      Fujio K, Okamoto A, Tahara H, Abe M, Jiang Y, Kitamura T, Hirose S, Yamamoto K.
    • Journal Title

      J Immunol. 173

      Pages: 2118-2125

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390285
  • [Journal Article] Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease2004

    • Author(s)
      Fujio K, Yamamoto K 他7名
    • Journal Title

      J Immunol 173

      Pages: 2118-2125

    • Data Source
      KAKENHI-PROJECT-15078101
  • [Patent] B細胞活性化の抑制剤及び自己免疫疾患の治療剤2014

    • Inventor(s)
      山本一彦ほか5名
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-11-28
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] Evaluation of human immune function for vaccine development2022

    • Author(s)
      Yamamoto K.
    • Organizer
      McGill-RIKEN Symposium (Montreal, Canada ) September
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Presentation] Data-driven functional analysis of human lymphocytes2022

    • Author(s)
      Yamamoto K.
    • Organizer
      Tsinghua RIKEN Joint workshop (on line) November
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Presentation] Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis2022

    • Author(s)
      Yamamoto K. Ishigaki K.
    • Organizer
      International Forum of Rheumatoid Arthritis 2022 (Beijing, China , on line), September
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Presentation] Human immune diversity for infection and vaccine development2022

    • Author(s)
      Yamamoto K.
    • Organizer
      RIKEN-KI-SciLifeLab Symposium (Stockholm, Sweden) October
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Presentation] Immunogenetics of rheumatoid arthritis & way forward2022

    • Author(s)
      Yamamoto K.
    • Organizer
      24th Asia-Pacific League of Associations for Rheumatology (Hong Kong, China), December
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Presentation] Dynamic Landscape of immune cell-specific gene regulation.2021

    • Author(s)
      山本一彦
    • Organizer
      The 13th International Forum on Rheumatoid Arthritis (IFRA2021)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Presentation] 統合オミックス解析による関節リウマチ関連遺伝子の同定2019

    • Author(s)
      鈴木亜香里、高地雄太、石垣和慶、山本一彦
    • Organizer
      第34回日本整形外科学会基礎学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Presentation] Integration of genetic information to immune functions2019

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      11th International Forum on Rheumatoid Arthritis. September 25-27, September 2019, Washington DC, USA
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Presentation] Mapping genes to immune cells2019

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      EULAR (European League Against Rheumatism) 12-15, June 2019 Madrid, Spain
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Presentation] Integration of Genetic information to immune functions2019

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      Advanced Target Therapies. 27-31 March 2019 Palma, Spain
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Presentation] Genetics of Human Immune System2018

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      McGill RIKEN symposium, 12-13rd
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Presentation] Genetics of rheumatic diseases2016

    • Author(s)
      山本 一彦
    • Organizer
      IRA - APLAR COURSE ON RHEUMATOLOGY
    • Place of Presentation
      Jakarta, Indonesia
    • Year and Date
      2016-02-24
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] Diagnosis and treatment of rheumatoid arthritis2016

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      21st Hong Kong Medical Forum
    • Place of Presentation
      Hong Kong
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05787
  • [Presentation] NOVEL THERAPEUTIC TARGETS IN AUTOIMMUNITY - TGF-beta3 AS A NOVEL TARGET OF IMMUNOTHERAPY2016

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      10th International Congress on Autoimmunity
    • Place of Presentation
      Germany
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05787
  • [Presentation] Genetics of Rheumatoid Arthritis2016

    • Author(s)
      山本 一彦
    • Organizer
      18th Conference on Advances in Targeted Therapies(ATT)
    • Place of Presentation
      Palma ,Spain
    • Year and Date
      2016-03-18
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] Genomics and functional genomics of rheumatoid arthritis2016

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      the 18th Asia Pacific League of Associations for Rheumatology Congress (APLAR )
    • Place of Presentation
      Shanghai, China
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05787
  • [Presentation] Regulatory T cells in human diseases2015

    • Author(s)
      山本 一彦
    • Organizer
      11th International Congress on Systemic Lupus Erythematosus
    • Place of Presentation
      Vienna,Austria
    • Year and Date
      2015-09-01
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] A novel regulatory T cell subset controlling B cell functions: a combination of therapeutic cytokines2015

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      7th International Forum on Rheumatoid Arthritis (IFRA)
    • Place of Presentation
      Beijing, China
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05787
  • [Presentation] Regulatory T cells in human diseases2015

    • Author(s)
      Kazuhiko Yamamoto
    • Organizer
      11th International Congress on Systemic Lupus Erythematosus
    • Place of Presentation
      Vienna, Austria
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05787
  • [Presentation] A novel regulatory T cell subset controlling B cell functions: a combination of therapeutic cytokines2015

    • Author(s)
      山本 一彦
    • Organizer
      7th International Forum on Rheumatoid Arthritis (IFRA)
    • Place of Presentation
      北京,中国
    • Year and Date
      2015-08-29
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] Genetics and Epigenetics of Rheumatoid Arthritis2015

    • Author(s)
      山本 一彦
    • Organizer
      The 17th Asia Pacific League of Associations for Rheumatology Congress
    • Place of Presentation
      Chenna,iIndia
    • Year and Date
      2015-09-06
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] CD4+CD25-LAG3+ Regulatory T Cells Control B Cell Responses2014

    • Author(s)
      山本一彦
    • Organizer
      The Immune system in health and disease
    • Place of Presentation
      ハイデルベルグ(ドイツ)
    • Year and Date
      2014-12-08
    • Invited
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] A brief history of GWAS and next generation genetics of RA2014

    • Author(s)
      山本一彦
    • Organizer
      Rheumatoid arthritis genetics meeting
    • Place of Presentation
      ボストン(米国)
    • Year and Date
      2014-11-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] TGF-beta3-Producing CD4+CD25-LAG3+ Regulatory T Cells Control B Cell Responses

    • Author(s)
      山本一彦
    • Organizer
      Cold Spring Habor Asia 2014
    • Place of Presentation
      上海(中国)
    • Year and Date
      2014-09-02 – 2014-09-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] Current and future genetics of rheumatoid arthritis in Asia

    • Author(s)
      山本一彦
    • Organizer
      The 59th Annual Meeting of the Japan Society of Human Genetics
    • Place of Presentation
      東京(日本)
    • Year and Date
      2014-11-19 – 2014-11-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] Novel Regulatory T cells controlling autoantibody production

    • Author(s)
      山本一彦
    • Organizer
      ACA香港(招待講演)
    • Place of Presentation
      香港
    • Invited
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] From Genetics to Functional Insights into the Pathogenesis of Rheumatoid arthritis

    • Author(s)
      山本一彦
    • Organizer
      APLAR(招待講演)
    • Place of Presentation
      バリ
    • Invited
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] Genetics is a fundamental of epigenetics in autoimmune diseases

    • Author(s)
      山本一彦
    • Organizer
      The 58th Annual Meeting of Japan College of Rheumatology
    • Place of Presentation
      東京(日本)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] From Genetics to Functional Insights of Autoimmune Diseases

    • Author(s)
      山本一彦
    • Organizer
      Taiwan Rheumatology Forum(招待講演)
    • Place of Presentation
      台湾
    • Invited
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] Genetics of Rheumatoid Arthritis:Functional insights into the pathogenesis

    • Author(s)
      山本一彦
    • Organizer
      Karolinska大学(招待講演)
    • Place of Presentation
      スウェーデン
    • Invited
    • Data Source
      KAKENHI-PROJECT-23229007
  • [Presentation] From Genetics to Functional Insights into the Pathogenesis of Rheumatoid Arthritis

    • Author(s)
      山本一彦
    • Organizer
      Advances in Targeted Therapies(招待講演)
    • Place of Presentation
      ニース
    • Invited
    • Data Source
      KAKENHI-PROJECT-23229007
  • []

  • 1.  MISAKI Yoshiikata (60219615)
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  • 73.  宮 冬樹
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