Urata Hidehito 浦田秀仁

… Alternative Names

浦田秀仁ウラタヒデヒト

URATA Hidehito 浦田秀仁

URATA Hidehtio 浦田秀仁

Less

Researcher Number	80211085
Other IDs
Affiliation (Current)	2025: 大阪医科薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2023: 大阪医科薬科大学, 薬学部, 教授 2021: 大阪医科薬科大学, 薬学部, 教授 2019 – 2020: 大阪薬科大学, 薬学部, 教授 2017: 大阪薬科大学, 薬学部, 教授(移行) 2010 – 2016: 大阪薬科大学, 薬学部, 教授 2005 – 2007: 大阪薬科大学, 薬学部, 教授 1994 – 1997: 大阪薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / 医薬分子機能学 / Bio-related chemistry / Chemistry related to living body Except Principal Investigator General pharmacology / Functional materials/Devices / Drug development chemistry
Keywords	Principal Investigator プロドラッグ型RNA / 還元環境応答型 / プロドラッグ型核酸 / siRNA / 銀(I)イオン / プライマー伸長反応 / DNAポリメラーゼ / 金属錯体型塩基対 / アンチセンス / オリゴヌクレオチド … More / 還元環境応答性 / 無臭性チオール / ジスルフィド / 第二世代 / ApoB / 還元環境に応答する / Apolipoprotein B / ホモ接合体家族性高コレステロール血症 / 家族性高コレステロール血症 / 還元環境 / プロドラッグ型 / 核酸医薬 / ５位修飾ピリミジン塩基 / Hg(II)イオン / Ag(I)イオン / 水銀(II)イオン / Carbocyclic Nucleoside / Conformational fixation / L-Nucleoside / Oligonucleotide / Antisense / オリゴヌクレチド / コンホメーション固定 / 炭素環ヌクレオシド / L-ヌクレオシド / Ag(I)-mediated base pair / primer extension / Ag(I) ion / DNA polymerase / metal-mediated base pair / L-ヌクレオチド … More Except Principal Investigator HIF-1α / sex hormone / gender difference / raloxifene / hypoxia / monocrotaline / Pulmonary hypertension / endothelin / モノクロタリンピロル / エンドセリン受容体 / エストラジオール / ラロシフェン / 性ホルモン / 性差 / ラロキシフェン / 低酸素 / モノクロタリン / 肺性高血圧 / エンドセリン / ポリメラーゼ / 除去 / 検出 / DNA合成酵素 / 等温滴定型カロリメトリー / 結晶解析 / NMR / 機能性核酸 / 金属含有DNA / 水銀イオン / 水銀イオン検出 / ナノワイヤー / 多次元多核種NMR法 / 結晶構造解析 / 水銀イオンの検出 / 水銀イオンの除去 / 環境浄化 / 核酸医薬品 / アンチセンス / 核酸医薬 / ヘリックス / 膜透過性ペプチド / Aib Less

Second-generation prodrug-type siRNA responsive to intracellular reducing environmentPrincipal Investigator
- Principal Investigator
  
  浦田秀仁
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Osaka Medical and Pharmaceutical University
Design of siRNA-based prodrug-type therapeutics for familial hypercholesterolemiaPrincipal Investigator
- Principal Investigator
  
  Urata Hidehito
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Osaka Medical and Pharmaceutical University
  Osaka University of Pharmaceutical Sciences
Regulation of DNA polymerase-catalyzed primer extension reaction based on formation of metal-mediated base pairsPrincipal Investigator
- Principal Investigator
  
  Urata Hidehito
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Osaka University of Pharmaceutical Sciences
Development of DNA based heavy metal ions removing membranes and nanowires-structures, properties, applications.
- Principal Investigator
  
  Ono Akira
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional materials/Devices
- Research Institution
  Kanagawa University
Recognition of metal-mediated base pairs by DNA polymerasesPrincipal Investigator
- Principal Investigator
  
  URATA Hidehito
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Osaka University of Pharmaceutical Sciences
Development of membrane-permeable Aib-containing peptide for delivery of oligonucleotide drugs
- Principal Investigator
  
  WADA Shun-ichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University of Pharmaceutical Sciences
Role of endothelin-1 and gender difference in the pathogenesis of pulmonary hypertension
- Principal Investigator
  
  MATSUMURA Yasuo
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University of Pharmaceutical Sciences
Design of Novel Antisense Nucleic Acids with Resistance for Nuclease digestionPrincipal Investigator
- Principal Investigator
  
  URATA Hidehito
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University of Pharmaceutical Sciences
ヌクレアーゼ耐性を有する新規アンチセンスヌクレオチドの分子設計Principal Investigator
- Principal Investigator
  
  浦田秀仁
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University of Pharmaceutical Sciences

All 2022 2021 2020 2019 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] 医薬品におけるDDS技術開発と製剤への応用　第３章第3節核酸医薬における化学修飾核酸の概要と研究開発2021
- Author(s)
  林淳祐、和田俊一、浦田秀仁
- Total Pages
  401
- Publisher
  情報機構
- ISBN
  9784865022278
- Data Source
  KAKENHI-PROJECT-19K05702
[Book] 月刊「化学」2015
- Author(s)
  舩井達也、浦田秀仁
- Total Pages
  2
- Publisher
  化学同人
- Data Source
  KAKENHI-PROJECT-15K05574
[Journal Article] REDUCT-siRNA：細胞内還元環境に応答して活性化するプロドラッグ型RNA創薬2020
- Author(s)
  林　淳祐、和田　俊一、浦田　秀仁
- Journal Title
  
  Medical Science Digest
  
  Volume: 46 Pages: 582-585
- Data Source
  KAKENHI-PROJECT-19K05702
[Journal Article] Influence of lysine residue in amphipathic helical peptides on targeted delivery of RNA into cancer cells2019
- Author(s)
  Wada Shun-ichi、Taniguchi Kohei、Hamazaki Hiroaki、Yamada Azusa、Hayashi Junsuke、Uchiyama Kazuhisa、Urata Hidehito
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Issue: 15 Pages: 1934-1937
- DOI
  10.1016/j.bmcl.2019.05.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08660, KAKENHI-PROJECT-19K05702
[Journal Article] α-Aminoisobutyric Acid-Containing Amphipathic Helical Peptide-Cyclic RGD Conjugation as a Potential Drug Delivery System for MicroRNA Replacement Therapy in Vitro2019
- Author(s)
  Taniguchi Kohei、Wada Shun-ichi、Ito Yuko、Hayashi Junsuke、Inomata Yosuke、Lee Sang-Woong、Tanaka Tomohito、Komura Kazumasa、Akao Yukihiro、Urata Hidehito、Uchiyama Kazuhisa
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 16 Issue: 11 Pages: 4542-4550
- DOI
  10.1021/acs.molpharmaceut.9b00680
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08660, KAKENHI-PROJECT-19K05702
[Journal Article] Structures, physicochemical properties, and applications of T-HgII-T, C-AgI-C, and other metallo-base-pairs.2015
- Author(s)
  Yoshiyuki Tanaka, Jiro Kondo, Vladimir Sychrovsky, Jakub Sebera, Takenori Dairaku, Hisao Saneyoshi, Hidehito Urata, Hidetaka Torigoe and Akira Ono
- Journal Title
  
  Chem. Commun.
  
  Volume: 51 Issue: 98 Pages: 17313-17360
- DOI
  10.1039/c5cc02693h
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05574, KAKENHI-PROJECT-15K13734, KAKENHI-PROJECT-24245037, KAKENHI-PROJECT-14J03684, KAKENHI-PROJECT-24310163, KAKENHI-PROJECT-26288084
[Journal Article] Regulated Incorporation of Two Different Metal Ions into Programmed Sites in a Duplex by DNA Polymerase Catalyzed Primer Extension2014
- Author(s)
  Tatsuya Funai, Junko Nakamura, Yuki Miyazaki, Risa Kiriu, Osamu Nakagawa, Shunichi Wada, Akira Ono, and Hidehito Urata*
- Journal Title
  
  Angew. Chem. Int. Ed
  
  Volume: 53 Issue: 26 Pages: 6624-6627
- DOI
  10.1002/anie.201401152
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24245037
[Journal Article] Regulated Incorporation of Two Different Metal Ions into Programmed Sites in a Duplex by DNA Polymerase Catalyzed Primer Extension2014
- Author(s)
  Tatsuya Funai, Junko Nakamura, Yuki Miyazaki, Risa Kiriu, Osamu Nakagawa, Shunichi Wada, Akira Ono, and Hidehito Urata
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 53 Issue: 26 Pages: 6624-6627
- DOI
  10.1002/anie.201311235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24245037, KAKENHI-PROJECT-24550199
[Journal Article] Cellular Uptake of Covalent Conjugates of Oligonucleotide with Membrane-modifying Peptide, Peptaibol2012
- Author(s)
  Shun-ichi Wada, Yasunari Hitora, Saori Yokoe, Osamu Nakagawa, and Hidehito Urata
- Journal Title
  
  Bioorg. & Med. Chem
  
  Volume: 20 Pages: 3219-3222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590109
[Journal Article] AgI Ion Mediated Formation of a C–A Mispair by DNA Polymerases2012
- Author(s)
  Tatsuya Funai
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 51 Issue: 26 Pages: 6464-6466
- DOI
  10.1002/anie.201109191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24245037, KAKENHI-PROJECT-24550199
[Journal Article] Cellular uptake of Aib-containing amphipathic helix peptide2011
- Author(s)
  和田俊一, 津田浩和, 岡田てる美, 浦田秀仁
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: VOL.21 Issue: 19 Pages: 5688-5691
- DOI
  10.1016/j.bmcl.2011.08.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590109
[Journal Article] Cellular Uptake of Aib-containing Amphi- pathic Helix Peptide2011
- Author(s)
  Shun-ichi Wada, Hirokazu Tsuda, Terumi Okada, and Hidehito Urata
- Journal Title
  
  Bioorg. & Med. Chem. Lett
  
  Volume: 21 Pages: 5688-5691
- URL
  http://dx.doi.org/10.1016/j.bmcl.2011.08.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590109
[Presentation] プロドラッグ型ホスホトリエステル修飾ギャップマー型核酸の合成とその2022
- Author(s)
  杉本紀人、林淳祐、船木涼平、保積慧美、和田郁人、斯波真理子、和田俊一、浦田秀仁
- Organizer
  日本薬学会第143年会（名古屋）
- Data Source
  KAKENHI-PROJECT-19K05702
[Presentation] プロドラッグ型ホスホトリエステル修飾を導入したGapmer核酸の合成とその評価2021
- Author(s)
  杉本紀人、林淳祐、船木涼平、保積恵美、和田郁人、斯波真理子、和田俊一、浦田秀仁
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-19K05702
[Presentation] 細胞内を模倣した還元的環境で活性化するプロドラッグ型核酸創薬2020
- Author(s)
  浦田秀仁
- Organizer
  医工薬連関科学研究発表会
- Data Source
  KAKENHI-PROJECT-19K05702
[Presentation] Syntheses and properties of reducing environment responsive prodrug-type oligonucleotides bearing cyclic and linear disulfide moieties2019
- Author(s)
  J. Hayashi, R. Funaki, N. Sugimoto, Y. Ochi, S. Wada, H. Urata
- Organizer
  Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry（Kobe）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05702
[Presentation] 細胞内還元環境に応答する直鎖ジスルフィド修飾を施したプロドラッグ型リン酸トリエステル(PTE) 核酸の合成2019
- Author(s)
  林淳祐、船木涼平、越智洋輔、和田俊一、浦田秀仁
- Organizer
  日本薬学会第139年会、3月（千葉）
- Data Source
  KAKENHI-PROJECT-19K05702
[Presentation] ペプチド性キャリアMAP(Aib)-cRGD によるmicroRNA-145 の細胞内導入2019
- Author(s)
  和田俊一、谷口高平、林淳祐、内山和久、浦田秀仁
- Organizer
  日本薬学会第139年会、3月（千葉）
- Data Source
  KAKENHI-PROJECT-19K05702
[Presentation] Properties of reducing-environment-responsive prodrug-type phosphate-modified oligonucleotides for development of oligonucleotide therapeutics.2019
- Author(s)
  J. Hayashi, R. Funaki, N. Sugimoto, Y. Ochi, S. Wada, H. Urata
- Organizer
  The 46th International Symposium on Nucleic Acids Chemistry（Tokyo）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05702
[Presentation] 還元環境に応答するプロドラッグ型 RNA の配列拡張を指向した合成研究2019
- Author(s)
  越智洋輔、林淳祐、森田康之、西垣美沙、和田俊一、浦田秀仁
- Organizer
  日本薬学会第139年会、3月（千葉）
- Data Source
  KAKENHI-PROJECT-19K05702
[Presentation] Aib 含有ペプチドによる microRNA-145 の細胞内導入大腸癌細胞増殖抑制効果2019
- Author(s)
  和田俊一、谷口高平、林淳祐、内山和久、浦田秀仁
- Organizer
  第37回メディシナルケミストリーシンポジウム（東京）
- Data Source
  KAKENHI-PROJECT-19K05702
[Presentation] 細胞内還元環境に応答するプロドラッグ型リン酸部修飾DNAの変換効率の比較2019
- Author(s)
  杉本紀人、船木涼平、林淳祐、越智洋輔、和田俊一、浦田秀仁
- Organizer
  日本核酸医薬学会第5回年会、7月（大阪）
- Data Source
  KAKENHI-PROJECT-19K05702
[Presentation] DNA polymerase による金属錯体型塩基対の形成に対する pyrimidine 5 位修飾の影響2017
- Author(s)
  吉村沙奈子、林淳祐、和田俊一、浦田秀仁
- Organizer
  第67回日本薬学会近畿支部総会・大会（兵庫医療大学）
- Data Source
  KAKENHI-PROJECT-15K05574
[Presentation] Influences of Zn(Ⅱ) and Mn(Ⅱ) ions on fidelity of DNA polymerases2016
- Author(s)
  杉町莉世、田中菜摘、舩井達也、宮崎有紀、林淳祐、和田俊一、浦田秀仁
- Organizer
  第43回国際核酸化学シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2016-09-27
- Data Source
  KAKENHI-PROJECT-15K05574
[Presentation] Cu(Ⅰ)の配位による新規C-Cu(Ⅰ)-T 型塩基対の形成2015
- Author(s)
  中田賢、舩井達也、宮崎有紀、林淳祐、和田俊一、浦田秀仁
- Organizer
  第65回日本薬学会近畿支部大会
- Place of Presentation
  大阪大谷大学
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15K05574
[Presentation] Formation of silver(I) ion-mediated C-T mispair by DNA polymerases2013
- Author(s)
  Junko Nakamura, Tatsuya Funai, Osamu Nakagawa, Shun-ichi Wada, Hidehito Urata
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kanagawa University
- Data Source
  KAKENHI-PROJECT-24550199
[Presentation] Formation of consecutive thymine-Hg(II)-thymine base pairs catalyzed by DNA polymerases2013
- Author(s)
  Chizuko Tagawa,　Tatsuya Funai, Osamu Nakagawa, Shun-ichi Wada,　Hidetaka Torigoe, Akira Ono, and Hidehito Urata
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kanagawa University
- Data Source
  KAKENHI-PROJECT-24550199
[Presentation] C-A および C-T ミスマッチ塩基対に及ぼす AgI の影響2013
- Author(s)
  舩井達也、青谷恵美、中川治、和田俊一、浦田　秀仁
- Organizer
  日本薬学会第１３３年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24550199
[Presentation] Formation of consecutive thymine-HgII-thymine base pairs catalyzed by DNA polymerases2013
- Author(s)
  Chizuko Tagawa, Tatsuya Funai, Osamu Nakagawa, Shun-ichi Wada, Hidetaka Torigoe, Akira Ono, and Hidehito Urata,
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  Kanagawa University
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] Aib 含有両親媒性へリックスペプチドを用いたオリゴヌクレオチドの細胞内移送2013
- Author(s)
  橋本佑樹,津田浩和,中川治,和田俊一,浦田秀仁
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PROJECT-22590109
[Presentation] Silver(I) Ion-Mediated Cytosine-Adenine Base Pairs Recognized by DNA polymerases2012
- Author(s)
  Hidehito Urata
- Organizer
  The 39th International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] ミスマッチ塩基対を含む二重鎖DNAの熱安定性に及ぼすAgIイオンの効果2012
- Author(s)
  青谷恵美、中川治、和田俊一、鳥越秀峰、小野晶、浦田秀仁
- Organizer
  第６２回日本薬学会近畿支部大会
- Place of Presentation
  武庫川女子大学
- Data Source
  KAKENHI-PROJECT-24550199
[Presentation] DNA polymeraseによるC-AgI-A錯体型塩基対の形成2012
- Author(s)
  舩井達也、宮崎有紀、青谷恵美、山口瑛理子、中川治、和田俊一、鳥越秀峰、小野晶、浦田秀仁
- Organizer
  第６２回日本薬学会近畿支部大会
- Place of Presentation
  武庫川女子大学
- Data Source
  KAKENHI-PROJECT-24550199
[Presentation] Designed Aib-containing amphipathic helix peptide for oligonucleotide delivery into cells2012
- Author(s)
  和田俊一,橋本侑樹,津田浩和,中川治, 浦田秀仁
- Organizer
  第49回ペプチド討論会
- Place of Presentation
  鹿児島
- Year and Date
  2012-11-08
- Data Source
  KAKENHI-PROJECT-22590109
[Presentation] Silver(I) Ion-Mediated Cytosine-Adenine Base Pairs Recognized by DNA polymerases.2012
- Author(s)
  T. Funai, Y. Miyazaki, M. Aotani, E. Yamaguchi, O. Nakagawa, S. Wada, H. Torigoe, A. Ono, H. Urata
- Organizer
  第39回国際核酸化学シンポジウム
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-24550199
[Presentation] DNAポリメラーゼによるミスマッチ塩基対形成に金属イオンが及ぼす影響の網羅的検討2012
- Author(s)
  宮崎有紀、舩井達也、中川治、和田俊一、浦田秀仁
- Organizer
  第６２回日本薬学会近畿支部大会
- Place of Presentation
  武庫川女子大学
- Data Source
  KAKENHI-PROJECT-24550199
[Presentation] TV-XIIa-オリゴヌクレオチド複合体のアンチセンス効果の検討2012
- Author(s)
  和田俊一,横江沙緒里,人羅康匠,中川治,浦田秀仁
- Organizer
  日本薬学会第132 年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22590109
[Presentation] TV-XIIa-オリゴヌクレオチド複合体のアンチセンス効果の検討2012
- Author(s)
  和田俊一, 横江沙緒里, 人羅康匠, 中川治, 浦田秀仁
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22590109
[Presentation] AgI存在下におけるDNAポリメラーゼによるC-Tミスマッチ塩基対の形成2012
- Author(s)
  中村淳子、舩井達也、宮崎有紀、山口瑛理子、中川治、和田俊一、浦田秀仁
- Organizer
  第６２回日本薬学会近畿支部大会
- Place of Presentation
  武庫川女子大学
- Data Source
  KAKENHI-PROJECT-24550199
[Presentation] Conjugates of antisense oligonucleotides with Aib-containing peptide : effects on cellular uptake and antisense effect2011
- Author(s)
  和田俊一, 人羅康匠, 横江沙緒里, 浦田秀仁
- Organizer
  第48回ペプチド討論会
- Place of Presentation
  札幌コンベンションセンター(札幌)
- Year and Date
  2011-09-28
- Data Source
  KAKENHI-PROJECT-22590109
[Presentation] Aib 含有両親媒性ヘリックスペプチドを用いたオリゴヌクレオチドの細胞膜透過性検討2011
- Author(s)
  津田浩和,岡田てる美,和田俊一,浦田秀仁
- Organizer
  第61回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-22590109
[Presentation] Conjugates of antisense oligonucleotides with2011
- Author(s)
  和田俊一,人羅康匠,横江沙緒里,浦田秀仁
- Organizer
  Aib-containing peptide: effects on cellular uptake and antisense effect
- Place of Presentation
  札幌
- Year and Date
  2011-09-28
- Data Source
  KAKENHI-PROJECT-22590109
[Presentation] Aib 含有両親媒性ヘリックスペプチドの細胞膜透過性2011
- Author(s)
  津田浩和,岡田てる美,和田俊一,浦田秀仁
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-22590109
[Presentation] Aib含有両親媒性ヘリックスペプチドの細胞膜透過性2011
- Author(s)
  津田浩和, 岡田てる美, 和田俊一, 浦田秀仁
- Organizer
  日本薬学会代131年会
- Place of Presentation
  ツインメッセ静岡(静岡県)
- Year and Date
  2011-03-31
- Data Source
  KAKENHI-PROJECT-22590109
[Presentation] Aib含有両親媒性ヘリックスペプチドを用いたオリゴヌクレオチドの細胞膜透過性検討2011
- Author(s)
  津田浩和, 岡田てる美, 和田俊一, 浦田秀仁
- Organizer
  第61回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸学院大学ポートアイランドキャンパス(兵庫)
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-22590109
[Presentation] Recognition of Metal-Mediated Base Pairs by DNA Polymerases
- Author(s)
  Tatsuya Funai, Junko Nakamura, Yuki Miyazaki, Risa Kiriu, Osamu Nakagawa, Shun-ichi Wada, Akira Ono, and Hidehito Urata
- Organizer
  第24回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都薬科大学
- Year and Date
  2014-06-14 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-24550199
[Presentation] DNA polymerase による銀(I) 錯体型塩基対形成の塩基選択性
- Author(s)
  桐生里紗，舩井達也，中村淳子，林淳祐，和田俊一，浦田秀仁
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24550199
[Presentation] DNA polymeraseによるT-Hg(II)-T錯体型塩基対の連続形成反応の検討
- Author(s)
  田川知津子、舩井達也、中川治、和田俊一、鳥越秀峰、小野晶、浦田秀仁
- Organizer
  第63回日本薬学会近畿支部大会
- Place of Presentation
  同志社女子大学
- Data Source
  KAKENHI-PROJECT-24550199
[Presentation] Ag(I)存在下におけるDNAポリメラーゼによるC-Tミスマッチ塩基対の形成
- Author(s)
  中村淳子、舩井達也、中川治、和田俊一、浦田秀仁
- Organizer
  第63回日本薬学会近畿支部大会
- Place of Presentation
  同志社女子大学
- Data Source
  KAKENHI-PROJECT-24550199
[Presentation] Syntheses and characterizations of DNA duplexes having metal ion mediated base pairs
- Author(s)
  Akira Ono, Itaru Okamoto, Hidehito Urata, Hidetake Torigoe, Hisao Saneyoshi, Jiro Kondo, Yoshiyuki Tanaka
- Organizer
  16th Symposium on Chemistry of Nucleic Acid Components
- Place of Presentation
  Cesky Krumlov, Czech Republic
- Year and Date
  2014-06-08 – 2014-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-24245037
[Presentation] yntheses of DNA duplexes containing metal ion mediated base pairs
- Author(s)
  Akira Ono, Itaru Okamoto, Hidehito Urata, Hidetake Torigoe, Hisao Saneyoshi, Jiro Kondo, Yoshiyuki Tanaka
- Organizer
  12th European Biological Inorganic Chemistry Conference
- Place of Presentation
  Zurich, Switzerland
- Year and Date
  2014-08-24 – 2014-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-24245037

1. WADA Shun-ichi (30278593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
2. Ono Akira (10183253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. KONDO Jiro (10546576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. SANEYOSHI Hisao (10564784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. TANAKA Yoshiyuki (70333797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. TORIGOE Hidetake (80227678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. MINAKAWA Noriaki (40209820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUMURA Yasuo (40140230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAKAOKA Masanori (50140231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 岡本到 (40460133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 斯波真理子 (70271575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 林淳祐 (30740295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. UCHIYAMA Kazuhisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 谷口高平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 赤尾幸博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Urata Hidehito 浦田 秀仁

浦田 秀仁 ウラタ ヒデヒト

URATA Hidehito 浦田 秀仁

URATA Hidehtio 浦田 秀仁

Research Projects

Research Products

Co-Researchers

Second-generation prodrug-type siRNA responsive to intracellular reducing environmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Design of siRNA-based prodrug-type therapeutics for familial hypercholesterolemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of DNA polymerase-catalyzed primer extension reaction based on formation of metal-mediated base pairsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of DNA based heavy metal ions removing membranes and nanowires-structures, properties, applications.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Recognition of metal-mediated base pairs by DNA polymerasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of membrane-permeable Aib-containing peptide for delivery of oligonucleotide drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of endothelin-1 and gender difference in the pathogenesis of pulmonary hypertension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design of Novel Antisense Nucleic Acids with Resistance for Nuclease digestionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヌクレアーゼ耐性を有する新規アンチセンスヌクレオチドの分子設計Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 医薬品におけるDDS技術開発と製剤への応用 第３章 第3節 核酸医薬における化学修飾核酸の概要と研究開発2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 月刊「化学」2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] REDUCT-siRNA：細胞内還元環境に応答して活性化するプロドラッグ 型RNA創薬2020

Author(s)

Journal Title

Data Source

[Journal Article] Influence of lysine residue in amphipathic helical peptides on targeted delivery of RNA into cancer cells2019

Author(s)

Journal Title

DOI

Urata Hidehito 浦田秀仁

浦田秀仁ウラタヒデヒト

URATA Hidehito 浦田秀仁

URATA Hidehtio 浦田秀仁

[Book] 医薬品におけるDDS技術開発と製剤への応用　第３章第3節核酸医薬における化学修飾核酸の概要と研究開発2021

[Journal Article] REDUCT-siRNA：細胞内還元環境に応答して活性化するプロドラッグ型RNA創薬2020