ISHIDA Hitoshi 石田均

Researcher Number	80212893
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2007 – 2019: Kyorin University, 医学部, 教授 1998 – 2005: 杏林大学, 医学部, 教授 1996 – 1997: Graduate School of Medicine, Kyoto Univ., 医学研究科, 助教授 1996: Kyoto University School of MedicineDepartment to Metabolism and clinixal Nutriti, 医学部・医学研究科, 助教授 1996: 京都大学医学部, 医学研究科, 助教授 … More
Review Section/Research Field	Principal Investigator Metabolomics / 内分泌・代謝学 / Metabolomics Except Principal Investigator 内分泌・代謝学 / Pathological medical chemistry / Applied health science / Eating habits / Endocrinology
Keywords	Principal Investigator 膵β細胞 / インスリン分泌 / ATP感受性K^+チャネル / 糖尿病 / パッチクランプ法 / ブドウ糖 / 2型糖尿病 / 細胞内カルシウム濃度 / 電位依存性Ca^<2+>チャネル / PPARγ … More Except Principal Investigator 糖尿病 / 膵β細胞 / インスリン / インスリン分泌 / 転写調節 / GFP / ブドウ糖 / diabetes mellitus / intracellular calcium / 細胞内カルシウム濃度 / ルシフェラーゼ・アッセイ / インスリン抵抗性 / 糖輸送担体 / Insulin / Glucose / Diabetes Mellitus / GIP / GLUT2 / SSTR2 / β細胞 / Pancreatic beta cell / パッチクランプ法 / insulin secretion / patch clamp technique / voltage-dependent Ca^<2+> channel / oral hypoglycemic agents / Pancreatic beta cells / Fusion / 赤血球型糖輸送担体 / 遺伝子転写調節領域 / グルコース / HepG2細胞 / ルシフェラーゼアッセイ / GRP / ゲルシフトアッセイ / DNase Iフット・プリント法 / 電位依存性カルシウムチャネル / クローニング / チャネル活性 / 遺伝子構造 / 多型性 / α_1サブユニット / GLUT1 / ゲルシフト・アッセイ / フット・プリント法 / HepG2 / 脂肪細胞 / 再生医療 / GLUT4 / アデノウイルス / アデノウィルス / 糖質制限食 / 肥満 / FGF21 / SCD1 / SSCP / 糖輸送担体(GLUT) / 筋肉 / 肝 / ラ氏島 / 遺伝子発見 / glucose transporter / diabetes / pancreatic beta cell / insulin / sscp / カルシウム / 膵ランゲルハンス島 / Calcium / Islet of Langerhans / 肝細胞 / CATアッセイ / GULT2 / 転写制御 / SSTR / Transcription / Hepatocyte / CAT assay / Luciferase assay / 経口血糖降下剤 / 電位依存性Ca^<2+>チャネル / バッチクランプ法 / pancreatic beta cells / 遺伝子 / 変異 / 電位依存性カルシウム・チャネル / GIP受容体 / PCR-SSCP法 / Gene / Mutation / Glucose Transporter / Voltage-dependent Calcium Channel / GIP Receptor / PCR-SSCP / 細胞内カルシウム / 細胞間結合 / intercellular gap junction / ATP感受性K^+チャネル / スルフォニルウレア受容体 / 共焦点レーザー顕微鏡 / エヴァネッセント / 分泌顆粒 / fusion / Exocytosis / SNARE / Ca^<2+> / confocal microscoov / evanescent / secretory granule / 骨代謝 / 糖尿病骨代謝異常 / 温熱処理 / 糖尿病性骨代謝異常 / 骨芽細胞 / VEGF / 乳酸 / GPT / 肝機能障害 / GOT / ビリルビン / 脂肪肝 / アディポカイン / 代謝学 / グルココルチコイド / グルココルチコイド受容体 GR / Proprotein Converse PC / non-genomic / 慢性炎症 / 炎症性サイトカイン / proprotein converts PC / non-genomic effect / プロインスリン / 構成性分泌経路 / 調節性分泌経路 / グルコルチコイド受容体 / 内科 / ストレス Less

The investigation on the pathological significance for lactate in insulin resistance.
- Principal Investigator
  
  HOSAKA TOSHIO
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  University of Shizuoka
  Kyorin University
Newly identified molecular mechanisms of insulin secretion from pancreatic beta-cells in response to extracellular stress
- Principal Investigator
  
  Kondo Takuma
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kyorin University
The elucidation of underlying mechanism and the establishment of therapeutic strategy on the abnormal bone metabolism of diabetes
- Principal Investigator
  
  Takahashi Kazuto
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Kyorin University
糖質制限食に対する生体反応～糖尿病モデルマウスを用いた遺伝子学的検索～
- Principal Investigator
  
  犬飼浩一
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Kyorin University
Elucidation of molecular mechanisms on macrophage infiltration into pancreatic islets in type 2 diabetes and challenging trial to establish its preventive strategy.Principal Investigator
- Principal Investigator
  
  Ishida Hitoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyorin University
Elucidation of involved mechanisms for macrophage infiltration into pancreatic islets and of its role on the occurrence of type 2 diabetes.Principal Investigator
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyorin University
Elucidation of involved mechanisms impaired for insulin secretion due to oxidative stress and macrophages in pancreatic islets of type 2 diabetes.Principal Investigator
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyorin University
New strategy for treatment of type 2 diabetes by utilizing the regeneration of pancreatic β cell functionPrincipal Investigator
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyorin University
脂肪細胞を利用したインスリン分泌機構の再構成
- Principal Investigator
  
  NAGAMATSU Shinya
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyorin University
Molecular physiological and biological studies on the effect of free fatty acids on pancreatic β cell functionPrincipal Investigator
- Principal Investigator
  
  ISHIDA Hitoshi, 古川尚志
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyorin University
Elucidation of the mechanism of impaired insulin release in diabetes mellitus by the molecular cell biological techniques
- Principal Investigator
  
  NAGAMATSU Shinya
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyorin University
膵β細胞SUレセプターとATP感受性K+チャネルの機能的連関と糖尿病での異常Principal Investigator
- Principal Investigator
  
  石田均
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Molecular physiological and biological studies on the mechanismof impaired glucose-induced insulin secretion in diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyorin University
  Kyoto University
膵β細胞ATP感受性K^+チャネルとSUレセプターの機能協関と糖尿病における異常Principal Investigator
- Principal Investigator
  
  石田均
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Development of new hypoglycemic agents with a novel insulinotropic mechanism and their clinical appkicatior
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
膵β細胞でのATP感受性K^+チャネルと糖輸送担体の機能協関と糖尿病における異常Principal Investigator
- Principal Investigator
  
  石田均
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
A study on the beta-Cell glucose sensors in insulin secretion : The relationship between dysfunction of glucose sensors and development of diabetes mellitus
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
Physiological and molecular biological studies on the pathogenesis of impaired insulin secretion in diabetes mellitus.Principal Investigator
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
a study concerning the pathway of calcium waves within the clusters of pancreatic beta cells
- Principal Investigator
  
  TSUJI Kazuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  TAZUKE KOFUKAI MEDICAL RESEARCH INSTITUTE.
グルコース飢餓における赤血球型糖輸送担体(GLUT1)発現増強機構の解析
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
カルシウムチャネル活性化に伴う神経細胞死に関する研究
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
高親和性糖輸送担体の発現抑制による細胞増殖抑制作用に関する研究
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Development of new hypoglycemic agents with a novel insulinotropic mechanism and their clinical application
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
The analysis of transcriptional regulation in a series of glucose responsive genes.
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
Physiological and molecular biological studies on functional alterations in ion channels of pancreatic beta cells in diabetes mellitus.Principal Investigator
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
Molecular Biological Studies of Calcium Signaling in Insulin Secretion ; their implication for the development of diabetes mellitus
- Principal Investigator
  
  SEINO Susumu
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Chiba University
Roles of various types of glucose transporter gene in diabetes mellitus
- Principal Investigator
  
  SEINO Yutaka, 井村裕夫
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto University
Physiological and molecular biological studies on altered function of the intracellular signal transduction system in pancreatic beta cells of diabetes mellitus.Principal Investigator
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY

[Book] 人体の構造と機能及び疾病の成り立ち22016
- Author(s)
  志村二三夫、石田　均
- Total Pages
  204
- Publisher
  建帛社
- Data Source
  KAKENHI-PROJECT-25461363
[Book] 人体の構造と機能及び2015
- Author(s)
  志村二三夫、石田　均
- Total Pages
  283
- Publisher
  建帛社
- Data Source
  KAKENHI-PROJECT-25461363
[Book] 人体の構造と機能及び疫病の成り立ち　各論．改訂第2版2013
- Author(s)
  香川靖雄、近藤和雄、石田均、門脇孝
- Total Pages
  591
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25461363
[Book] 人体の構造と機能及び疫病の成り立ち　総論．改訂第2版2013
- Author(s)
  香川靖雄、近藤和雄、石田均、門脇孝
- Total Pages
  341
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25461363
[Book] 膵臓移植. 出月康夫、野澤眞澄監修2009
- Author(s)
  西田進, 石田均ら(分担執筆)
- Total Pages
  474
- Publisher
  シュプリンガー・ジャパン
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Serum lactate levels are associated with serum alanine aminotransferase and total bilirubin levels in patients with type 2 diabetes mellitus: A cross-sectional study2019
- Author(s)
  Ishitobi Minori、Hosaka Toshio、Morita Naru、Kondo Ken、Murashima Toshitaka、Kitahara Atsuko、Takahashi Kazuto、Sumitani Yoshikazu、Tanaka Toshiaki、Yokoyama Toshihiko、Kondo Takuma、Ishida Hitoshi
- Journal Title
  
  Diabetes Research and Clinical Practice
  
  Volume: 149 Pages: 1-8
- DOI
  10.1016/j.diabres.2019.01.028
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00868
[Journal Article] Novel mechanisms modulating palmitate-induced inflammatory factors in hypertrophied 3T3-L1 adipocytes by AMPK.2018
- Author(s)
  Morita N, Hosaka T, Kitahara A, MurashimaT, Onuma H, Sumitani Y, Takahashi K, Tanaka T, Kondo T, Ishida H
- Journal Title
  
  Journal of Diabetes Research
  
  Volume: なし
- DOI
  10.1155/2018/9256482
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00868
[Journal Article] Metabolic Effects of Tofogliflozin are Efficiently Enhanced with Appropriate Dietary Carbohydrate Ratio and are Distinct from Carbohydrate Restriction.2018
- Author(s)
  Ito S, Hosaka T, Yano W, Itou T, Yasumura M, Shimizu Y, Kobayashi H, Nakagawa T, Inoue K, Tanabe S, Kondo T, Ishida H
- Journal Title
  
  physiological Reports
  
  Volume: なし
- DOI
  10.14814/phy2.13642
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00868
[Journal Article] Habitual exercise training acts as a physiological stimulator for constant activation of lipolytic enzymes in primary white adipocytes.2015
- Author(s)
  J.Ogasawara, T.Izawa, T.Sakurai, K.Shirota, Y.Ishibashi, Y.Ohira, H.Ishida, H.Ohno, and T.Kizaki.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 464 Pages: 348-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461363
[Journal Article] Comparisons of microRNA expression profiles in vitreous humor between eyes with macular hole and eyes with proliferative diabetic retinopathy.2015
- Author(s)
  K. Hirota, H. Keino, M. Inoue, H. Ishida, and A. Hirakata
- Journal Title
  
  Graefes Arch Clin Exp Ophthalmol
  
  Volume: 253 Pages: 335-342
- DOI
  10.1007/s00417-014-2692-5
- Data Source
  KAKENHI-PROJECT-25461363
[Journal Article] The association between impaired proinsulin processing and type 2 diabetes mellitus in non-obese Japanese individuals2015
- Author(s)
  H.Katsuta, S.Ozawa, K.Suzuki, K.Takahashi, T.Tanaka, Y.Sumitani, S.Nishida, T.Kondo, T.Hosaka, and H.Ishida.
- Journal Title
  
  Endocrine Journal
  
  Volume: 62(6) Issue: 6 Pages: 485-492
- DOI
  10.1507/endocrj.ej14-0611
  10.1507/endocrj.EJ14-0611
- NAID
  130005085772
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461363
[Journal Article] Ghrelin augments the expressions and secretions of proinflammatory adipokines, VEGF120 and MCP-1, in differentiated 3T3-L1 adipocytes2015
- Author(s)
  A. Kitahara, K. Takahashi, R. Moriya, H. Onuma, K. Handa, Y. Sumitani, T. Tanaka, H. Katsuta, S. Nishida, T. Sakurai, K. Inukai, H. Ohno, and H. Ishida.
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: 230 Pages: 199-209
- DOI
  10.1002/jcp.24699
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461363, KAKENHI-PROJECT-15K01626
[Journal Article] Effects of long-term monotherapy with glimepiride vs glibenclamide on glycemic control and macrovascular events in Japanese type 2 diabetic patients.2014
- Author(s)
  H.Onuma, K.Inukai, M.Watanabe, Y.Sumitani, T.Hosaka, and H.Ishida.
- Journal Title
  
  J Diabetes Mellitus
  
  Volume: 4(1) Pages: 33-37
- DOI
  10.4236/jdm.2014.41006
- Data Source
  KAKENHI-PROJECT-25461363
[Journal Article] Possible involvement of PI3K-dependent pathways in the increased VEGF120 release from osteoblastic cells preloaded with palmitate.2014
- Author(s)
  R. Moriya, K. Takahashi, A. Kitahara, H. Onuma, K. Handa, Y. Sumitani, T. Tanaka, H.Katsuta, S. Nishida, E. Itagaki, K. Inukai, and H. Ishida.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 445 Pages: 275-281
- DOI
  10.1016/j.bbrc.2014.01.120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461363
[Journal Article] Estimated proinsulin processing activity of prohormone convertase (PC) 1/3 rather than PC2 is decreased in pancreatic β-cells of type 2 diabetic patients.2014
- Author(s)
  S.Ozawa*, H.Katsuta*, K.Suzuki, K.Takahashi, T.Tanaka, Y.Sumitani, S.Nishida, K.Yoshimoto, and H.Ishida. (*equally contributed)
- Journal Title
  
  Endocr J
  
  Volume: 61(6) Pages: 607-614
- NAID
  130004770451
- Data Source
  KAKENHI-PROJECT-25461363
[Journal Article] Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.2014
- Author(s)
  Handa K, Inukai K, Onuma H, Kudo A, Nakagawa F, Tsuruga K, Kitahara A, Moriya R, Takahashi K, Sumitani Y, Hosaka T, Kawakami H, Oyadomari S, Ishida H
- Journal Title
  
  PLoS One.
  
  Volume: 9 Pages: 104948-104948
- DOI
  10.1371/journal.pone.0104948
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25350898, KAKENHI-PROJECT-25461363, KAKENHI-PROJECT-26670270
[Journal Article] Enzyme-treated asparagus officinalis extract shows neuroprotective effects and attenuates cognitive impairment in senescence-accelerated mice.2014
- Author(s)
  T. Sakurai, T. Ito, K.Wakame, K. Kitadate, T.Arai, J. Ogasawara, T. Kizaki, S.Sato, Y.Ishibashi,T.Fujiwara, K.Akagawa H. Ishida, and H. Ohno.
- Journal Title
  
  Natural Product Commun
  
  Volume: 9(1) Pages: 101-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461363
[Journal Article] Endogenous oxidative stress, but not ER stress, induces hypoxia-independent VEGF120 release through PI3K-dependent pathways in 3T3-L1 adipocytes2013
- Author(s)
  Takahashi, K., et al.
- Journal Title
  
  Obesity
  
  Volume: 21 Pages: 1615-1624
- DOI
  10.1002/oby.20206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300223, KAKENHI-PROJECT-25461363, KAKENHI-PROJECT-25560340
[Journal Article] Higher levels of ATGL are associated with exercise-induced enhancement of lipolysis in rat epididymal adipocytes2012
- Author(s)
  J. Ogasawara, T. Sakurai, T. Kizaki, Y. Ishibashi, T. Izawa, Y. Sumitani, H. Ishida, Z. Radak, S. Haga, and H. Ohno
- Journal Title
  
  PLoS ONE
  
  Volume: 7(7)
- Data Source
  KAKENHI-PROJECT-22590993
[Journal Article] Induction of mitochondrial uncoupling enhances VEGF (120) but reduces MCP-1 release in mature 3T3-L1 adipocytes : Possible regulatory mechanism through endogenous ER stress and AMPK-related pathways2012
- Author(s)
  Miyokawa-Gorin, K., Takahashi, K., Handa, K., Kitahara, A., Sumitani, Y., Katsuta, H., Tanaka, T., Nishida, S., Yoshimoto, K., Ohno, H. & Ishida, H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 419 Pages: 200205-200205
- DOI
  10.1016/j.bbrc.2012.01.145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300237, KAKENHI-PROJECT-22590993, KAKENHI-PROJECT-22650154
[Journal Article] Induction of mitochondrial uncoupling enhances VEGF120 but reduces MCP-1 release in mature 3T3-L1 adipocytes: possible regulatory mechanism through endogenous ER stress and AMPK-related pathways.2012
- Author(s)
  K. Miyokawa-Gorin *, K. Takahashi *, K. Handa, A. Kitahara, Y. Sumitani, H. Katsuta, T. Tanaka, S. Nishida, K. Yoshimoto, H. Ohno, and H. Ishida.(*equally contributed)
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 419 Pages: 200-205
- Data Source
  KAKENHI-PROJECT-22590993
[Journal Article] Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in co-culture of adipocytes and macrophages.2010
- Author(s)
  T.Sakurai, H.Ishida, et al.
- Journal Title
  
  J Nutr Biochem 23
  
  Pages: 1626-1633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Hormone-sensitive lipase is critical mediators of acute exercise-induced regulation of lipolysis in rat adipocytes2010
- Author(s)
  J. Ogasawara, S. Nomura, N. Rahman, T. Sakurai, T. Kizaki, T. Izawa, H. Ishida, S. Haga and H. Ohno.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 400 Pages: 134-139
- Data Source
  KAKENHI-PROJECT-22590993
[Journal Article] Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/Raf-1/MEK 112 cascade independent of the IL-6 signaling pathway in rat primary adipocytes.2010
- Author(s)
  J.Ogasawara, H.Ishida, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 402 Pages: 554-559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590993
[Journal Article] Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in co-culture of adipocytes and macrophages.2010
- Author(s)
  T.Sakurai, H.Ishida, et al.
- Journal Title
  
  J Nutr Biochem
  
  Volume: 23 Pages: 1626-1633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590993
[Journal Article] Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in co-culture of adipocytes and macrophages.2010
- Author(s)
  T. Sakurai, K. Kitadate, H. Nishioka, H. Fujii, T. Kizaki, Y. Kondoh, T. Izawa, H. Ishida, Z. Radak, H. Ohno
- Journal Title
  
  J Nutr Biochem 23
  
  Pages: 1626-1633
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Effect of exercise training on adipogenesis of stromal-vascular fraction cells in rat epididymal white adipose tissue2010
- Author(s)
  T. Sakurai, S. Endo, D. Hatano, J. Ogasawara, T. Kizaki, S. Oh-ishi, T. Izawa, H. Ishida, and H. Ohno
- Journal Title
  
  Acta Physiol
  
  Volume: 200 Pages: 325-338
- Data Source
  KAKENHI-PROJECT-22590993
[Journal Article] Effect of exercise training on adipogenesis of stromal-vascular fraction cells in rat epididymal white adipose tissue.2010
- Author(s)
  T.Sakurai, H.Ishida, et al.
- Journal Title
  
  Acta Physiol
  
  Volume: 200 Pages: 325-338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590993
[Journal Article] Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/Raf-1/MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes.2010
- Author(s)
  J. Ogasawara, K. Kitadate, H. Nishioka, H. Fujii, T. Sakurai, T. Kizaki, T. Izawa, H. Ishida, H. Tanno, and H. Ohno
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 402 Pages: 554-559
- Data Source
  KAKENHI-PROJECT-22590993
[Journal Article] Enhanced release of monocyte chemoattractant protein-1 (MCP-1) by high glucose and free fatty acid and its underlying mechanism in MIN6 Bcells.2009
- Author(s)
  H. Seki, H. Ishida, et al.
- Journal Title
  
  J Kyorin Med Soc (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway.2009
- Author(s)
  J.Ogasawara, H.Ishida, et al.
- Journal Title
  
  Phytotherapy Res 21
  
  Pages: 47-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue.2009
- Author(s)
  T. Sakurai, H. Ishida, et al.
- Journal Title
  
  Biochem Biophys Res Commun 379
  
  Pages: 605-609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue.2009
- Author(s)
  T.Sakurai, H.Ishida, et al.
- Journal Title
  
  Biochem Biophys Res Commun 379
  
  Pages: 605-609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue.2009
- Author(s)
  T. Sakurai, T. Izawa, T. Kizaki, J. Ogasawara, K. Shirato, K. Imaizumi, K. Takahashi, H. Ishida, H. Ohno
- Journal Title
  
  Biochem Biophys Res Commun 379
  
  Pages: 605-609
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway.2009
- Author(s)
  J. Ogasawara, K. Kitadate, H. Nishioka, H. Fujii, T. Sakurai, T. Kizaki, T. Izawa, H. Ishida, H. Ohno
- Journal Title
  
  Phytotherapy Res 21
  
  Pages: 47-54
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition.2008
- Author(s)
  T. Kishino, K. Watanabe, T. Urata, M. Takano, T. Uemura, K. Nishikawa, Y. Mine, M. Matsumoto, K. Ohtsuka, H. Ohnishi, H. Mori, S. Takahashi, H. Ishida, T. Watanabe
- Journal Title
  
  Clin Chim Acta 398
  
  Pages: 57-62
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] JNK-and IκB-dependent pathways regulate MCP-1, but not adiponectin, release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro.2008
- Author(s)
  K. Takahashi, S. Yamaguchi, T. Shimoyama, H. Seki, K. Miyokawa, H. Katsuta, T. Tanaka, K. Yoshimoto, H. Ohno, S. Nagamatsu, H. Ishida
- Journal Title
  
  Am J Physiol 294
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Enhanced release of monocyte chemoattractant protein-1 (MCP-1) by high glucose and free fatty acid and its underlying mechanism in MIN6βcells.2008
- Author(s)
  H. Seki, K. Takahashi, K. Miyokawa, K. Handa, H. Katsuta, S. Yamaguchi, K. Yoshimoto, E. Itagaki, S. Nagamatsu, H. Ishida
- Journal Title
  
  J Kyorin Med Soc 39
  
  Pages: 31-36
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Increased bone resorption may play a crucial role in the occurrence of osteopenia in patients with type 2 diabetes: possible involvement of accelerated polyol pathway in its pathogenesis.2008
- Author(s)
  M. Takizawa, K. Suzuki, T. Matsubayashi, M. Kikuyama, H. Suzuki, K. Takahashi, H. Katsuta, J. Mitsuhashi, S. Nishida, S. Yamaguchi, K. Yoshimoto, E. Itagaki, H. Ishida
- Journal Title
  
  Diabetes Res Clin Pract 82
  
  Pages: 119-126
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] JNK-and IκB-dependent pathways regulate MCP-1,but not adiponectin,release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro.2008
- Author(s)
  K.Takahashi, H.Ishida, et. al.
- Journal Title
  
  Am J Physiol 294(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] JNK- and IkB-dependent pathways regulate MCP-1, but not adiponectin, release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro.2008
- Author(s)
  T. Takahashi, H. Ishida, et al.
- Journal Title
  
  Am J Physiol 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells.2007
- Author(s)
  T.Uehara, H.Ishida, et. al.
- Journal Title
  
  Int J Mol Med 19
  
  Pages: 895-900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Gliclazide inhibits proliferation but stimulates differentiation of white and brown adipocytes.2007
- Author(s)
  N.Nakano, H.Ishida, et. al.
- Journal Title
  
  J Biochem 142
  
  Pages: 639-645
- NAID
  10020095721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591065
[Journal Article] Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation.2006
- Author(s)
  T.Shimoyama, H.Ishida, et al.
- Journal Title
  
  Metabolism 55
  
  Pages: 722-730
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation.2006
- Author(s)
  T.Shimoyama, H.Ishida, et al.
- Journal Title
  
  Metabolism (in press)
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] Osteoclastic function is accelerated in male patients with type 2 diabetes mellitus : the preventive role of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG) on the decrease of bone mineral density.2005
- Author(s)
  K.Suzuki, H.Ishida et al.
- Journal Title
  
  Diabetes Res Clin Pract 68
  
  Pages: 117-125
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] Gliclazide protects 3TLI adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation.2005
- Author(s)
  T.Shimoyama, H.Ishida et al.
- Journal Title
  
  Metabolism 55
  
  Pages: 722-730
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] Osteoclastic function is accelerated in male patients with type 2 diabetes mellitus : the preventive role of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG) on the decrease of bone density.2005
- Author(s)
  K.Suzuki, H.Ishida, et al.
- Journal Title
  
  Diabetes Res Clin Pract 68
  
  Pages: 117-125
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3TLI adipocytes2005
- Author(s)
  S.Yamaguchi, H.Ishida et al.
- Journal Title
  
  Am J Physiol 289
  
  Pages: 5643-5649
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3L1 adipocytes.2005
- Author(s)
  S.Yamaguchi, H.Ishida, et al.
- Journal Title
  
  Am J Physiol 289
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] PPAR-γ overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 protein.2004
- Author(s)
  H.Ito, H.Ishida, et al.
- Journal Title
  
  Biochem Biophys Res Commun 324
  
  Pages: 810-814
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] Pioglitazone improves insulin secretory capacity and prevents the loss of βcell mass in obese diabetic db/db mice : possible protection of βcells from oxidative stress.2004
- Author(s)
  H.Ishida, M.Takizawa, et al.
- Journal Title
  
  Metabolism 53
  
  Pages: 488-494
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] PPAR-gamma over expression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 protein.2004
- Author(s)
  H.Ito, H.Ishida et al.
- Journal Title
  
  Biochem Biophys Res Commun 324
  
  Pages: 810-814
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] Pioglitazone improves insulin secretory capacity and prevents the loss of beta-cell mass in obese diabetic db/db mice : possible protection of beta cells from oxidative stress.2004
- Author(s)
  H.Ishida, M.Takizawa et al.
- Journal Title
  
  Metabolism 53
  
  Pages: 488-494
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] PPAR-γ overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UPC-2 protein.2004
- Author(s)
  H.Ito, H.Ishida, et al.
- Journal Title
  
  Biochem Biophys Res Commun 324
  
  Pages: 810-814
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] Insulinotropic action of glutamate is dependent on the inhibition of ATP-sensitive potassium channel activities in MIN6 βcells.2003
- Author(s)
  H.Katsuta, H.Ishida, et al.
- Journal Title
  
  Biochem Biophys Res Commun 311
  
  Pages: 660-664
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] Insulinotropic action of glutamate is dependent on the inhibition of ATP-sensitive potassium channel activities in MIN 6 beta cells.2003
- Author(s)
  H.Katsuta, H.Ishida et al.
- Journal Title
  
  Biochem Biophys Res Commun 311
  
  Pages: 660-664
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] PPAR-γ overexpression suppresses glucose-induced proinsulin biosynthesis and insulin release synergistically with pioglitazone in MIN6 cells.2003
- Author(s)
  Y.Nakamichi, H.Ishida, et al.
- Journal Title
  
  Biochem Biophys Res Commun 306
  
  Pages: 832-836
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] Gliclazide protects pancreatic beta-cells from damage by hydrogen peroxide.2003
- Author(s)
  K.Kimoto, H.Ishida, et al.
- Journal Title
  
  Biochem Biophys Res Commun 303
  
  Pages: 112-119
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] An insulin-related peptide expressed in 3T3L1 adipocytes is localized in GLUT4 vesicles and secreted in response to exogenous insulin, which augments the insulin-stimulated glucose uptake.2003
- Author(s)
  Y.Nakamichi, H.Ishida, et al.
- Journal Title
  
  J Cell Sci 116
  
  Pages: 73-79
- Data Source
  KAKENHI-PROJECT-15590955
[Journal Article] Endogenous oxidative stress, but not ER stress, induces hypoxia-independent VEGF120 release through PI3K-dependent pathways in 3T3-L1 adipocytes.
- Author(s)
  K. Takahashi, K. Miyokawa-Gorin, K. Handa, A. Kitahara, R. Moriya, H. Onuma, Y. Sumitani, T. Tanaka, H. Katsuta, S. Nishida, K. Yoshimoto, H. Ohno and H. Ishida.
- Journal Title
  
  Obesity
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22590993
[Presentation] 膵β―細胞におけるパルミチン酸誘導性炎症反応へのアスタキサンチンの効果とオートファジー機構の関与2020
- Author(s)
  北原敦子、高橋和人、村嶋俊隆、近藤健、石飛実紀、保坂利男、近藤琢磨、石田均、安田和基
- Organizer
  第23回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] High-dose glucocorticoid reduces insulin secretion by suppressing Prohormone Convertase 1/3 through non-genomic pathway.2019
- Author(s)
  Toshitaka Murashima, Takuma Kondo, Hitoshi Ishida
- Organizer
  American Diabetes Association 79rd scientific sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09811
[Presentation] アシル化グレリンは脂肪細胞を介してインスリン抵抗性を惹起する.2019
- Author(s)
  北原敦子, 高橋和人, 森田奈瑠, 近藤健, 石飛実紀, 村嶋俊隆, 近藤琢磨, 保坂利男, 石田均
- Organizer
  第22回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 血清の肝脂肪非侵襲マーカーの可能性;糖尿病患者において空腹時乳酸値と肝脂肪化マーカーとが関連する.2018
- Author(s)
  石飛実紀,保坂利男,森田奈瑠,近藤健,村嶋俊隆,高橋和人,炭谷由計,田中利明,近藤琢磨,石田均
- Organizer
  第33回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 糖尿病患者における血清乳酸値増加の意義―インスリン抵抗性非侵襲代謝マーカーとしての可能性.2018
- Author(s)
  石飛実紀，保坂利男，森田奈瑠，村嶋俊隆，小沼裕寿，高橋和人，炭谷由計，田中利明，近藤琢磨，石田均
- Organizer
  第61回日本糖尿病学会学術総会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 糖尿病患者における血清乳酸値増加の意義-インスリン抵抗性非侵襲代謝マーカーとしての可能性-.2018
- Author(s)
  石飛実紀,保坂利男,森田奈瑠,近藤健,村嶋俊隆,高橋和人,炭谷由計,田中利明,近藤琢磨,石田均
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 肥大化3T3-L1脂肪細胞でのパルミチン酸誘導炎症性サイトカイン発現に対するAMPKの影響とその細胞内機構の検討.2018
- Author(s)
  森田奈瑠，保坂利男，北原敦子，村嶋俊隆，小沼裕寿，炭谷由計，田中利明，近藤琢磨，石田均
- Organizer
  第61回日本糖尿病学会学術総会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 2型糖尿病における骨代謝異常進展に関与する機序の解明，ならびにそれに対する温熱処理の影響の検討2018
- Author(s)
  高橋　和人、北原　敦子、森田　奈瑠、村嶋　俊隆、炭谷　由計、田中　利明、近藤　琢磨、保坂　利男、石田　均
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K01725
[Presentation] 糖尿病患者における血清乳酸値増加の意義-インスリン抵抗性非侵襲タイヤマーカーとしての可能性-2018
- Author(s)
  石飛実紀、保坂利男、石本麻衣、近藤健、森田奈瑠、村嶋俊隆、小沼裕寿、炭谷由計、近藤琢磨、石田均
- Organizer
  第21回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 膵β細胞への糖質コルチコイドの慢性大量投与が及ぼす核外でのnon-genomic effectとその病態生理学的意義について2018
- Author(s)
  村嶋俊隆、近藤琢磨、石田均
- Organizer
  第61回　日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09811
[Presentation] 糖尿病患者における血清乳酸値増加の意義-インスリン抵抗性非侵襲代謝マーカーとしての可能性-.2018
- Author(s)
  石飛実紀、保坂利男、森田奈瑠、村嶋俊隆、小沼裕寿、炭谷由計、田中利明、近藤琢磨、石田均
- Organizer
  第115回日本内科学会総会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] The Effect of AMPK Activation on Inflammatory Cytokine in Mature Hypertrophied 3T3-L1 Adipocyte2017
- Author(s)
  Morita N, Hosaka T, Kitahara A, Murashima T, Onuma H, Sumitani Y, Takahashi K, Tanaka T, Kondo T, Ishida H.
- Organizer
  American Diabetes Association 77rd scientific sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 肥大化脂肪細胞での炎症性サイトカイン発現に対するAMPK活性化の影響とメトフォルミンの効果について2017
- Author(s)
  森田奈瑠、保坂利男、北原敦子、村嶋俊隆、五林可織、小沼裕寿、炭谷由計、高橋和人、田中利明、近藤琢磨、石田均
- Organizer
  第60回日本糖尿病学会学術集会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 糖質コルチコイドが及ぼす膵β細胞機能への慢性効果とその分子メカニズムに関する検討2017
- Author(s)
  村嶋俊隆、近藤琢磨、石田均
- Organizer
  第60回　日本糖尿病学会年次学術集会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2017-05-18
- Data Source
  KAKENHI-PROJECT-16K09811
[Presentation] 肥大化脂肪細胞でのAMPK活性化が及ぼす炎症性サイトカイン発現に対する影響とその細胞内機構の検討2017
- Author(s)
  森田奈瑠、保坂利男、北原敦子、村嶋俊隆、小沼裕寿、五林可織、炭谷由計、高橋和人、田中利明、近藤琢磨、石田均
- Organizer
  第32回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 肥大化脂肪細胞での炎症性サイトカイン発現に対するAMPK活性化の影響とその生理的役割について2017
- Author(s)
  森田奈瑠、保坂利男、北原敦子、高橋和人、近藤琢磨、石田均
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 肥大化脂肪細胞でのサイトカイン発現におけるAMPK活性化の影響とその生理的役割について2016
- Author(s)
  森田奈瑠、保坂利男、北原敦子、村嶋俊隆、小沼裕寿、五林可織、高橋和人，炭谷由計，西田進，近藤琢磨，石田均
- Organizer
  第59回日本糖尿病学会学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K00868
[Presentation] 2型糖尿病における骨代謝異常の増悪・進展機構の解明とそれに対する温熱処理の影響の解析．2015
- Author(s)
  高橋和人，森谷理恵，北原敦子，半田桂子，小沼裕寿，炭谷由計，田中利明，勝田秀紀，西田進，近藤琢磨，保坂利男，犬飼浩一，石田均
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] 日本人のための糖尿病食事療法．2015
- Author(s)
  石田均
- Organizer
  第12回日本内科学会総会
- Place of Presentation
  京都
- Year and Date
  2015-04-10
- Invited
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] パルミチン酸負荷による骨芽細胞からのVEGF120分泌増大にはPI3K依存性の経路が関与している可能性がある．2015
- Author(s)
  森谷理恵，高橋和人，北原敦子，炭谷由計，小沼裕寿，田中利明，勝田秀紀，西田進，近藤琢磨，保坂利男，犬飼浩一，石田均
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] 2型糖尿病における骨代謝異常増悪・進展に関与する分子機構の解明ならびにそれに対する温熱処理の影響の検討．2015
- Author(s)
  高橋和人，北原敦子，森田奈瑠，村嶋俊隆，小沼裕寿，炭谷由計，田中利明，西田進，近藤琢磨，保坂利男，石田均
- Organizer
  第30回日本糖尿病合併症学会総会・第21回日本糖尿病眼学会総会
- Place of Presentation
  愛知県産業労働センター・ウインクあいち（愛知県名古屋市）
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-15K01725
[Presentation] 膵β細胞の酸化ストレス下におけるオートファジー機構の意義とアスタキサンチンの保護作用の検討．2015
- Author(s)
  北原敦子，近藤琢磨，高橋和人，村嶋俊隆，森田奈瑠，小沼裕寿，炭谷由計，田中利明，勝田秀紀，保坂利男，犬飼浩一，石田均
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] 2型糖尿病における骨代謝異常の増悪・進展機構の解明とそれに対する温熱処理の影響の解析．2015
- Author(s)
  高橋和人，森谷理恵，北原敦子，半田桂子，小沼裕寿，炭谷由計，田中利明，勝田秀紀，西田進，近藤琢磨，保坂利男，犬飼浩一，石田均
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関グランドホテル（山口県下関市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K01725
[Presentation] 2型糖尿病治療別にみるプロインスリンプロセシング機構の回復．2015
- Author(s)
  勝田秀紀，近藤琢磨，石本麻衣，森田奈瑠，村嶋俊隆，小沼裕寿，森谷理恵，高橋和人，田中利明，鈴木清，保坂利男，犬飼浩一，石田均
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] 肥大化脂肪細胞からの完全分泌型VEGF120の低酸素非依存的分泌制御機構の解明2013
- Author(s)
  高橋和人，北原敦子，森谷理恵，五林可織，半田桂子，小沼裕寿，炭谷由計，田中利明，勝田秀紀，西田進，犬飼浩一，石田均
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] 日本人の糖尿病食事療法に求められるもの2013
- Author(s)
  石田均
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] 飽和脂肪酸が及ぼす骨芽細胞機能への影響とその分子機構の解析2013
- Author(s)
  森谷理恵，高橋和人，北原敦子，五林可織，半田桂子，小沼裕寿，炭谷由計，田中利明，勝田秀紀，西田進，板垣英二，犬飼浩一，石田均
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] グレリンによる脂肪細胞からのアディポカイン分泌制御機構―MCP-1ならびにVEGF120分泌の促進作用とその分子機構の解明―2013
- Author(s)
  北原敦子，高橋和人，五林可織，半田桂子，森谷理恵，小沼裕寿，炭谷由計，田中利明，勝田秀紀，西田進，板垣英二，犬飼浩一，石田均
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] 温熱処理によるHSP72発現の増強と脂肪細胞由来炎症関連アディポカインの分泌動態の変化について2012
- Author(s)
  高橋和人,北原敦子,五林可織,半田桂子,森谷理恵,小沼裕寿,炭谷由計,田中利明,勝田秀紀,西田進,吉元勝彦,石田均
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590993
[Presentation] 脂肪細胞からの炎症関連アディポカイン分泌における温熱処理の影響とその意義.2012
- Author(s)
  高橋和人,北原敦子,森谷理恵,五林可織,半田桂子,小沼裕寿,炭谷由計,田中利明,勝田秀紀,西田進,犬飼浩一,石田均
- Organizer
  第33回日本肥満学会
- Place of Presentation
  京都
- Year and Date
  2012-10-11
- Data Source
  KAKENHI-PROJECT-22590993
[Presentation] 脂肪細胞からのアディポネクチン分泌に及ぼすmitochondrial uncoupling の影響とその制御機構に関わる細胞内情報伝達系の検討2011
- Author(s)
  五林可織,高橋和人,半田桂子,北原敦子,炭谷由計,田中利明,勝田秀紀,西田進,吉元勝彦,板垣英二,石田均
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590993
[Presentation] Hypoxia- independent VEGF120 secretion is stimulated by increase of endogenous oxidative stress through PI3K-dependent pathways in artificially hypertrophied 3T3-L1 adipocytes: The regulation by distinct mechanism from MCP-1 via JNK and p38 MAPK pathways2010
- Author(s)
  K. Takahashi, S. Yamaguchi, T. Shimoyama, T. Tanaka, K. Miyokawa, K. Handa, H. Katsuta, S. Nishida, K. Yoshimoto, H. Ishida
- Organizer
  14th International Congress of Endocrinology
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19591065
[Presentation] 脂肪細胞のミトコンドリア内でのmetabolic couplingが細胞機能に果たす役割について2010
- Author(s)
  三代川可織,高橋和人,半田桂子,黒川三知子,森谷理恵,下山達宏,田中利明,勝田秀紀,山口真哉,吉元勝彦,石田均
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22590993
[Presentation] 肥大化脂肪細胞におけるVEGF120分泌の制御機構について-MCP-1分泌機構との相違-2009
- Author(s)
  高橋和人, 山口真哉, 下山達宏, 田中利明, 三代川可織, 半田桂子, 勝田秀紀, 西田進, 吉元勝彦, 永松信哉, 石田均
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19591065
[Presentation] Glucolipotoxicityによる膵β細胞からのMCP-1分泌の増加と細胞内情報伝達系の関与2008
- Author(s)
  関博之, 高橋和人, 三代川可織, 半田桂子, 勝田秀紀, 下山達宏, 田中利明, 山口真哉, 吉元勝彦, 板垣英二, 永松信哉, 石田均
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591065
[Presentation] Glucolipotoxicityによる膵β細胞からのMCP-1分泌の増加と細胞内情報伝達系の関与.2008
- Author(s)
  関博之, 石田均ら
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591065
[Presentation] 膵β細胞からのMCP-1分泌に及ぼす高濃度グルコースおよび脂肪酸の影響について.2007
- Author(s)
  関博之, 石田均, ら
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591065
[Presentation] 膵β細胞からのMCP-1分泌に及ぼす高濃度グルコースおよび脂肪酸の影響について2007
- Author(s)
  関博之, 高橋和人, 伊藤英介, 勝田秀紀, 田中利明, 下山達宏, 山口真哉, 吉元勝彦, 永松信哉, 石田均
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591065
[Presentation] 糖尿病での骨代謝異常における基盤病態の解明とそれに対する温熱処理の影響の検討．
- Author(s)
  高橋和人，森田理恵，北原敦子，半田桂子，小沼裕寿，村嶋俊隆，炭谷由計，田中利明，勝田秀紀，西田進，犬飼浩一，石田均
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] 膵β細胞保護効果に対するアスタキサンチンの細胞内作用機構に関する検討―ケモカインのMCP-1の分泌動態への影響―．
- Author(s)
  北原敦子，高橋和人，森谷理恵，小沼裕寿，半田桂子，森田奈瑠，石本麻衣，炭谷由計，田中利明，勝田秀紀，西田進，犬飼浩一，石田均
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] Direct action of ghrelin enhance the secretions of proinflammatory adipokines from mature 3T3-L1 adipcocytes in vitro.
- Author(s)
  Kitahara A, Takahashi K, Moriya R, Onuma H, Handa K, Sumitani Y, Tanaka T, Katsuta H, Nishida S, Sakurai T, Inukai K, Ohno H, Ishida H
- Organizer
  The American Diabetes Association's 73nd Scientific Sessions,
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-06-13 – 2014-06-17
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] VEGF120 secretion from palmitate-preloaded osteoblastic cells is enhanced through the activation of PI3K-dependent pathways.
- Author(s)
  Moriya R, Takahashi K, Kitahara A, Onuma H, Handa K, Sumitani Y, Tanaka T, Katsuta H, Nishida S, Itagaki E, Inukai K, Ishida H
- Organizer
  The American Diabetes Association's 73nd Scientific Sessions,
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-06-13 – 2014-06-17
- Data Source
  KAKENHI-PROJECT-25461363
[Presentation] 糖尿病モデルマウスにおける長期糖質制限食投与の影響に関する遺伝子学的検討
- Author(s)
  犬飼浩一、半田桂子、小沼裕寿、炭谷由計、保坂利男、北原敦子、森谷理恵、高橋和人、田中利明、勝田秀紀、西田進、板垣英二、石田均
- Organizer
  第57回日本糖尿病学会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-25350898
[Presentation] 骨芽細胞からのサイトカイン分泌に及ぼす飽和脂肪酸の影響とその細胞内シグナル伝達経路に関する検討
- Author(s)
  森田理恵，高橋和人，北原敦子，小沼裕寿，半田桂子，炭谷由計，田中利明，勝田秀紀，西田進，板垣英二，犬飼浩一，石田均
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461363

1. SEINO Yutaka (40030986)

# of Collaborated Projects: 15 results

# of Collaborated Products: 0 results
2. NAGAMATSU Shinya (80231489)

# of Collaborated Projects: 7 results

# of Collaborated Products: 5 results
3. INUKAI Kouichi (20333007)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
4. SEINO Susumu (80236067)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. TSUDA Kinsuke (10180001)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. HORIKOSHI Hiroyoshi

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. KATAHIRA Hitoshi (20327472)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YOSHIMOTO Katsuhiko (20271257)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
9. GONOI Tohru (30134365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMADA Yuichiro (60283610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TSUJI Kazuo (30250070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. WATANABE Takashi (00191768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Takahashi Kazuto (80508292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. HOSAKA TOSHIO (60403698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
15. Kondo Takuma (60431368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 今泉美佳 (40201941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 古川尚志 (90322445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. JOHNSON John H

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. FUJIMOTO Wilfred Y

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 井村裕夫

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. CHARLES F BU

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. GRAEME I BEL

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. BELL Graeme I

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. BURANT Charles

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. BURANT Charl

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. BELL Graeme

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. NEWGARD Chri

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. NEWGARD Christopher B

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. OYADOMARI Seiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 大野秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. 櫻井拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIDA Hitoshi 石田 均

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Elucidation of molecular mechanisms on macrophage infiltration into pancreatic islets in type 2 diabetes and challenging trial to establish its preventive strategy.Principal Investigator

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Elucidation of involved mechanisms for macrophage infiltration into pancreatic islets and of its role on the occurrence of type 2 diabetes.Principal Investigator

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Elucidation of involved mechanisms impaired for insulin secretion due to oxidative stress and macrophages in pancreatic islets of type 2 diabetes.Principal Investigator

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New strategy for treatment of type 2 diabetes by utilizing the regeneration of pancreatic β cell functionPrincipal Investigator

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Molecular physiological and biological studies on the effect of free fatty acids on pancreatic β cell functionPrincipal Investigator

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膵β細胞SUレセプターとATP感受性K+チャネルの機能的連関と糖尿病での異常Principal Investigator

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Molecular physiological and biological studies on the mechanismof impaired glucose-induced insulin secretion in diabetes mellitusPrincipal Investigator

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膵β細胞ATP感受性K^+チャネルとSUレセプターの機能協関と糖尿病における異常Principal Investigator

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ISHIDA Hitoshi 石田均