SEINO Yutaka 清野裕

… Alternative Names

清野裕セイノユタカ

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Researcher Number	40030986
Other IDs
External Links
Affiliation (Current)	2023: 株式会社関西メディカルネット(関西電力医学研究所), 関西電力医学研究所, 所長 2023: 京都大学, 医学研究科, 名誉教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 株式会社関西メディカルネット(関西電力医学研究所), 関西電力医学研究所, 所長 2007 – 2011: Kyoto University, 医学研究科, 名誉教授 2004: Kyoto University, Graduate School of Medicine and Faculty of Medicine, emeritus Professor, 医学研究科, 名誉教授 1995 – 2003: Professor, Dept.of Metab.and Clin.Nutr.Kyoto University, School of Medicine,, 医学研究科, 教授 1999 – 2002: 京都大学, 大学院・医学研究科, 教授 … More 1998: 京都大学, 大学院医学研究科, 教授 1997: 京都大学, 大学院・医学研究科, 教授 1995: 京都大学, 医科研究科, 教授 1986 – 1994: 京都大学, 医学部, 助教授 1986: Division of Metabolism and Clinical Nutrition, Kyoto University, Faculty of Medicine, Associate Professor, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / Metabolomics / Metabolomics Except Principal Investigator 内分泌・代謝学 / General surgery / Clinical psychology
Keywords	Principal Investigator 膵β細胞 / 糖尿病 / GIP / 糖輸送担体 / GLUT2 / 転写調節 / PCR-SSCP / ソマトスタチン / cAMP / SSTR2 … More / インクレチン / GLP-1 / ソマトスタチン受容体 / クローニング / グルコース / インスリン / 電位依存性カルシウムチャネル / 細胞内カルシウム濃度 / ルシフェラーゼ・アッセイ / オクトレオチド / MAPキナーゼ / エネルギー / 糖質代謝異常 / ERストレス / β細胞 / アポトーシス / 糖輸送担体(GLUT) / ラ氏島 / 肝 / 筋肉 / ブドウ糖 / Pancreatic beta cell / インスリン分泌 / パッチクランプ法 / pancreatic beta cells / insulin secretion / diabetes mellitus / patch clamp technique / voltage-dependent Ca^<2+> channel / intracellular calcium / oral hypoglycemic agents / CREM / PKA / ATF2 / Tet expression system / 内分泌腫瘍 / 結合特性 / RT-PCR / ソマトスタチンアナログ / シンチグラフィー / がん / 糠輸送担体 / 脳腫瘍 / ソマトスタチンレセプター / 消化器癌 / 甲状腺癌 / インターロイキン / 赤血球型糖輸送担体 / 遺伝子転写調節領域 / HepG2細胞 / ルシフェラーゼアッセイ / GRP / ゲルシフトアッセイ / DNase Iフット・プリント法 / チャネル活性 / 遺伝子構造 / 多型性 / α_1サブユニット / GLUT1 / ゲルシフト・アッセイ / フット・プリント法 / HepG2 / NIDDM / ATP感受性カリウムチャネル / G蛋白質 / SSTR1 / 細胞内情報伝達系 / 細胞増殖抑制 / 細胞増殖 / 再生 / 秋田マウス / CHOP / Bip / XBP-1 / 肥満 / 遺伝子発現 / メッセンジャ-(m)RNA / 高血糖 / 高インスリン血症 / 低インスリン血症 / Diabetes mellitus / obesity / glucose transporter (GLUT) / gene expression / mRNA / islet / liver / nuscle / SSCP / 遺伝子発見 / glucose transporter / diabetes / pancreatic beta cell / insulin / sscp / 肝細胞 / CATアッセイ / GULT2 / 転写制御 / SSTR / Transcription / Hepatocyte / CAT assay / Luciferase assay / Glucose / 経口血糖降下剤 / 電位依存性Ca^<2+>チャネル / バッチクランプ法 / 遺伝子 / 変異 / 電位依存性カルシウム・チャネル / GIP受容体 / PCR-SSCP法 / Diabetes Mellitus / Gene / Mutation / Glucose Transporter / Voltage-dependent Calcium Channel / GIP Receptor / ATP感受性K^+チャネル / スルフォニルウレア受容体 / Pancreatic beta cells / インスリン遺伝子 / グルコース応答性 / CaMKIV / CRE / CRE-BP1 / CBP / p300 / TBP / カルシウムチャネル / calmodulin-dependent protein kinase IV / CRE-BPl / insulin gene / glucose-responsive / CaMK TV / 膵β細胞株 / SAGE法 / 転写因子 / 標的遺伝子 / 分化・増殖 / 膵Β細胞株 / 膵β細胞の発生と機能 / Tet Expression System / pancreatic β-cell line / SAGE / Transcription factor / Target gene / Proliferation and differentiation / 脂肪細胞 / 骨芽細胞 / incretin / adipocyte / osteoblast / 迷走神経 / 交感神経 / 膵 / Somatostatin / Vagus / Cholinergic neuron / Non cholinergic neuron / Obesity … More Except Principal Investigator 糖尿病 / インスリン分泌 / 膵β細胞 / パッチクランプ法 / ATP感受性K^+チャネル / インスリン / 糖輸送担体 / 血圧 / ブドウ糖 / 電位依存性Ca^<2+>チャネル / cyclic AMP / 細胞内カルシウム濃度 / Diabetes mellitus / Patch-clamp technique / ANP / 肝癌 / 膵癌 / 単クロ-ン抗体 / 甲状腺癌 / 成長ホルモン / 膵内分泌腫瘍 / 肝がん / 甲状腺がん / 遺伝子発現 / 成長因子 / インスリン遺伝子 / GLUT / cAMP / insulin gene / 細胞内情報伝達系 / 細胞内カルシウム / Intracellular calcium concentration / insulin / Pancreatic beta-cells / Insulin secretion / ATP-sensitive K^+ channels / 細胞内Ca^<2+>濃度 / diabetes mellitus / SNPs / オピオイドペプチド / ロイモルフィン / バソプレッシン / Leumorphin / BNP / CNP / POMC / GIP / 味覚応答 / 嗅覚応答 / 食欲促進物質 / インスリン受容体 / インスリン様成長因子 / 食品成分 / 嗅覚・味覚 / 摂食 / インスリン作用 / 増殖因子レセプタ- / IGF / 膵がん / ELISA / 免疫組織化学 / モノクロメ-ル抗体 / カゼイン / 脂肪細胞 / ソマトスタチン / 血圧降下作用 / アレルギー / 神経細胞 / 関節リュウマチ / コラーゲン / コレステロール / GLUT5 / IGFI / グルコキメーゼ / ソマスタチン / サポニン / 経口寛容 / アンジオテンシン / I変換酵素 / 細胞内ブドウ糖代謝 / スルフォルニルウレア受容体 / スルフォニルウレア受容体 / EGFレセプター / ブドウ糖輸送担体 / 単クローン抗体 / 味覚 / 食欲 / 膵酵素 / 糖代謝 / 自律神経 / 糖輸送担体(Glut) / Glut 1 / CAT アッセイ / Hep G2 / HeLa / CAT活性 / エンハンサ-領域 / プロモ-タ-領域 / ATP感受K_+チャネル / 電位依存Ca_<2+>チャネル / イオンチャネル / Intracellular signal transduction system / ATP-sensitive K^+ channel / Voltage-dependent Ca^<2+> channel / 転写 / CRE(cyclic AMP response element) / cAMP. / CRE(cyclic AMP response elenent) / CRE(cyclic AMP rospone element) / transcription / CRE (CAMP response element) / CAMP / パッチランプ法 / ATP感受性K^+チャンネル / 電位依存性Ca^<2+>チャンネル / Voltage-dependnet Ca^<2+> channels / Voltage-dependent Ca^<2+> channels / Intracellular Ca^<2+> / SNARE蛋白群 / カルモジュリン / サイクリックAMP / 電位依存性Ca_<2+>チャネル / バッチクランプ法 / 電位依存性CA^<2+>チャネル / insulin secrction / intraccllular calcium / SNARE protcins / calmodulin / ATP-sensitive KィイD1+ィエD1 channel / voltage-dependent calcium channel / 多因子疾患 / 遺伝子解析 / 遺伝子機能 / 遺伝子構造 / 相関解析 / 原因遺伝子解析 / 多遺伝子疾患 / multifactorial disease / genetic analysis / gene function / gene structure / association analysis / 生体膵島移植 / 生体ドナー / 膵島移植分離技術 / 心臓死ドナー / GMP施設 / 1型糖尿病 / 生体膵島移埴 / 膵島分離技術 / インスリン依存状態糖尿病 / 膵島移植 / GMP / ISO9001 / ブタ膵島 / 膵管保護 / 二層法膵保存 / Living donor islet transplantation / Living donor / Islet isolation method / Non-heart-beating donor / GMP facility / Type 1 diabetes / 下垂体ホルモン / 飲水 / 中枢性血圧調節 / プロラクチン / オピオイドペプタイド / ゴナドトロピン / 飲水行動 / 抗利尿ホルモン / 性週期 / Opioid Peptides / Pituitary Hormones / Blood Pressure / Vasopressin / Drinking / 分泌 / ホスホリパーゼC / GTP結合蛋白 / イノシトールリン酸 / Cキナーゼ / Isiet-Activating protein(IAP) / Inosital1,4,5-trisphosphate / 刺激伝達機構 / Insulin Secretion / Pancreatic Islet / GTP-Binding Protein / Phospholipase C / leumorphin / サイトカイン / モチリン / POMC 遺伝子 / ACTH / CRF / 神経内分泌学 / 視床下部 / インターロイキン / Cytokines / Motilin / ①心の健康度測定スケール「BUKK」 / ②ストレス / ③ウエルビーイング / ④ライフサイクル課題と危機 / ⑤心理介入 / ⑥高齢期糖尿病の療養指導教育 / ⑦療養指導教育プログラム / こころの健康度 / ストレス / ウェールビーイング / 中年クライシス / 高年クライシス / ライフタスク / 心理的介入 / 糖尿病患者の心理的特徴 / ライフサイクル / 療養指導 Less

Survey research on psycliological issues of the individuals with diavetes and the construction of an educational medical care program
- Principal Investigator
  
  Higashiyama Hiroko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical psychology
- Research Institution
  株式会社関西メディカルネット(関西電力医学研究所)
Investigation for intracellular mechanisms of pancreatic-cell proliferation and anti-apoptotic effect of incretinPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Effect of incretin on beta cell proliferation and prevention of diabetesPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Gut-peptides regulate metabolism in whole body.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Masaya, 清野裕
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kyoto University
Living donor islet transplantation for the treatment of sever diabetes
- Principal Investigator
  
  MATSUMOTO Shinichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KYOTO UNIVERSITY
Analysis of transcriptional network in pancreatic β-cellsPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  KYOTO UNIVERSITY
Comprehensive Analysis of Genetic Factors in Diabetes Mellitus
- Principal Investigator
  
  SEINO Susumu
- Project Period (FY)
  1998 – 2002
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Chiba University
膵β細胞SUレセプターとATP感受性K+チャネルの機能的連関と糖尿病での異常
- Principal Investigator
  
  石田均
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
ソマトスタチンによる腫瘍増殖抑制機構の解析Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Characterizetion of glucose-induced signal transduction and its impairment in type 2 diabetePrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Molecular physiological and biological studies on the mechanismof impaired glucose-induced insulin secretion in diabetes mellitus
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyorin University
  Kyoto University
膵β細胞ATP感受性K^+チャネルとSUレセプターの機能協関と糖尿病における異常
- Principal Investigator
  
  石田均
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
ソマトスタチンによる抗腫瘍効果の分子機構に関する研究Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Development of new hypoglycemic agents with a novel insulinotropic mechanism and their clinical appkicatiorPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
膵β細胞でのATP感受性K^+チャネルと糖輸送担体の機能協関と糖尿病における異常
- Principal Investigator
  
  石田均
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
糖尿病発症に関与する膵β細胞イオンチャネルの分子生物学的研究Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
A study on the beta-Cell glucose sensors in insulin secretion : The relationship between dysfunction of glucose sensors and development of diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
Physiological and molecular biological studies on the pathogenesis of impaired insulin secretion in diabetes mellitus.
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
食品の生体調節因子の解析と設計
- Principal Investigator
  
  上野川修一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
グルコース飢餓における赤血球型糖輸送担体(GLUT1)発現増強機構の解析Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
カルシウムチャネル活性化に伴う神経細胞死に関する研究Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
高親和性糖輸送担体の発現抑制による細胞増殖抑制作用に関する研究Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Development of new hypoglycemic agents with a novel insulinotropic mechanism and their clinical applicationPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
がんの産生する蛋白の診断への応用に関する研究Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
The analysis of transcriptional regulation in a series of glucose responsive genes.Principal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
Studies on the mechanism of transcription regulation of insulin gene in pancreatic B cell
- Principal Investigator
  
  TSUDA Kinsuke
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
Physiological and molecular biological studies on functional alterations in ion channels of pancreatic beta cells in diabetes mellitus.
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
インスリン分泌における糖輸送の分子機構Principal Investigator
- Principal Investigator
  
  清野裕
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Roles of various types of glucose transporter gene in diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka, 井村裕夫
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto University
Physiological and molecular biological studies on altered function of the intracellular signal transduction system in pancreatic beta cells of diabetes mellitus.
- Principal Investigator
  
  ISHIDA Hitoshi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
がんの産生する蛋白の診断への応用に関する研究
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
がんの産生する蛋白の診断への応用に関する研究
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1990 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Studies on molecular mechanism of etiology of diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Studies on negative regulation of insulin gene expression in non-pancreatic cells
- Principal Investigator
  
  TSUDA Kinsuke
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KYOTO UNIVERSITY
生体における食品成分の受容・応答の機作
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
生体における食品成分の受容・応答の機作
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
生体における食品成分の受容・応答の機作
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Grant-in-Aid for Scientific Research (A)
- Principal Investigator
  
  IMURA H
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
腫瘍におけるホルモンなどの活性物質の産生機構とその診断・治療への応用
- Principal Investigator
  
  IMURA Hiroo
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
腫瘍におけるホルモンなどの活性物質の産生とその診断・治療への応用
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
The Role and Activation Mechanism of Phospholipase C in Insulin Secretion
- Principal Investigator
  
  TAMINATO Tomohiko
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
Physiological and clinical significance of opioids and related peptides
- Principal Investigator
  
  IMURA Hiroo
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University
The role of somatostatin in pathophysiology of obesity and diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  SEINO Yutaka
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Kyoto University

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All Journal Article Presentation

[Journal Article] Beneficial Effects of Exendin-4 on Experimental Polyneuropathy in Diabetic Mice2012
- Author(s)
  Himeno T, Seino Y, et al.
- Journal Title
  
  Diabetes
  
  Volume: 60 Pages: 2397-2406
- DOI
  10.2337/db10-1462
- NAID
  40019261380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132, KAKENHI-PROJECT-21592506, KAKENHI-PROJECT-22590975, KAKENHI-PROJECT-22592322
[Journal Article] Immunoassays for incretin hormones GIP and GLP-12011
- Author(s)
  矢部大介、清野裕
- Journal Title
  
  日本臨床
  
  Volume: 69 Pages: 946-950
- NAID
  40018816647
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice2011
- Author(s)
  Ogawa E, Yamane S, Toyoda K, Seino Y, Inagaki N, et al.
- Journal Title
  
  Biochemical Biophysical Research Communication
  
  Volume: 404 Pages: 115-120
- NAID
  120002737766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] The history of incretin hormones.2011
- Author(s)
  Yabe D, Seino Y
- Journal Title
  
  日本臨床
  
  Volume: 69 Pages: 755-760
- NAID
  40018816616
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Understanding the incretin effect2011
- Author(s)
  Seino Y.
- Journal Title
  
  Journal of Endocrinology and Metabolism
  
  Volume: 96 Pages: 934-935
- DOI
  10.1210/jc.2011-0329
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] The history of incretin hormones2011
- Author(s)
  矢部大介、清野裕
- Journal Title
  
  日本臨床
  
  Volume: 69 Pages: 755-760
- NAID
  40018816616
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] GLP-1 receptor agonist attenuates ER stress-mediated ss-cell damage in Akita mice2011
- Author(s)
  Yamane S, Hamamoto Y, Toyoda K, Seino Y Inagaki N, et al.
- Journal Title
  
  J Diabetes Invest
  
  Volume: 2 Pages: 79-154
- DOI
  10.1111/j.2040-1124.2010.00075.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132, KAKENHI-PROJECT-22590975
[Journal Article] Two incretin hormones GLP-1 and GIP : Comparison of their actions in insulin secretion and β cell preservation2011
- Author(s)
  Yabe D, Seino Y
- Journal Title
  
  Progress in Biophysics and Molecular Biology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Two incretin hormones GLP-1 and GI : comparison of their actions in in sulin and β cell preservation2011
- Author(s)
  Yabe D, Seino Y.
- Journal Title
  
  Progress in Biophysics and Molecular Biology
  
  Volume: 107 Pages: 248-256
- DOI
  10.1016/j.pbiomolbio.2011.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice2011
- Author(s)
  Ogawa E, Yamane S, Toyoda K, Seino Y, Inagaki N, et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 404 Pages: 115-120
- DOI
  10.1016/j.bbrc.2010.11.077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Two incretin hormones GLP-1 and GIP : Comparison of their actions in insulin secretion andβcell preservation2011
- Author(s)
  Yabe D, Seino Y.
- Journal Title
  
  Progress in Biophysics and Molecular Biology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese : Comparison of type 2 diabetes patients and healthy controls2010
- Author(s)
  Yabe D, Kuroe A, Lee S, Watanabe K, Inagaki N, Seino Y, etal.
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 1 Pages: 56-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Improved glycaemic control with minimal hypoglycaemia and no weight change with the once-daily human glucagon-like peptide-1 analogue liraglutide as add-on to sulphonylurea in Japanese patients with type 2 diabetes.2010
- Author(s)
  Kaku K, Rasmussen MF, Clauson P, Seino Y.
- Journal Title
  
  Diabetes, Obesity and Metabolism
  
  Volume: 12 Pages: 341-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Exendin-4 Protects Pancreatic Beta Cells from the Cytotoxic Effect of Rapamycin by Inhibiting JNK and p38 Phosphorylation2010
- Author(s)
  Kawasaki Y, Toyoda K, Yamane S, Seino Y, N. Inagaki et al.
- Journal Title
  
  Horm Metab Horm Metab Res
  
  Volume: 42 Pages: 311-317
- DOI
  10.1055/s-0030-1249035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132, KAKENHI-PROJECT-22590975
[Journal Article] Improved glycaemic control with minimal hypoglycaemia and no weight change with the once-daily human glucagon-like peptide-1 analogue liraglutide as add-on to sulphonylurea in Japanese patients with type 2 diabetes.2010
- Author(s)
  Kaku K, Rasmussen MF, Clauson P, Seino Y.
- Journal Title
  
  Diabetes Obes Metab 12(4)
  
  Pages: 341-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Efficacy and safety of the once-daily human GLP-1 analogue, liraglutide, vsglibenclamide monotherapy in Japanese patients with type 2 diabetes.2010
- Author(s)
  Seino Y, Rasmussen MF, Nishida T, Kaku K.
- Journal Title
  
  Curr Med Res Opin 26(5)
  
  Pages: 1013-1022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] GIP and GLP-1, the two incretin hormones : Similarities and differences2010
- Author(s)
  Seino Y, Fukushima M, Yabe D.
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 1 Pages: 8-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control.2010
- Author(s)
  Widenmaier SB, Kim SJ, Yang GK, De Los Reyes T, Nian C, Asadi A, Seino Y, Kieffer TJ, Kwok YN, McIntosh CH
- Journal Title
  
  PLoS One 5(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms2010
- Author(s)
  Flock G, Holland D, Seino Y, Drucker DJ.
- Journal Title
  
  Endocrinology
  
  Volume: 152 Pages: 374-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Efficacy and safety of the once-daily human GLP-1 analogue, liraglutide, vsglibenclamide monotherapy in Japanese patients with type 2 diabetes.2010
- Author(s)
  Seino Y, Rasmussen MF, Nishida T, Kaku K.
- Journal Title
  
  Current Medical Research and Opinion
  
  Volume: 26 Pages: 1013-1022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Journal Article] Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice Gastroenterology2009
- Author(s)
  Maida A, Seino Y, et al.
- Volume
  137
- Pages
  2146-2157
- DOI
  10.1053/j.gastro.2009.09.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] The effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance2011
- Author(s)
  山根俊介、清野裕, et al
- Organizer
  47^<th> annual meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Lisbon, Portugal
- Year and Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] Clinical Implication of Incretin Treatment in Asian type 2 Diabetes2011
- Author(s)
  清野裕
- Organizer
  3rd AASD Plenary Lecture
- Place of Presentation
  北京、中国
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] The effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance2011
- Author(s)
  山根俊介、原田範雄、豊田健太郎、清野裕、稲垣暢也
- Organizer
  47th annual meeting of the European Association for the Study of Diabetes
- Place of Presentation
  リスボン、ポルトガル
- Year and Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] 糖尿病専門診療のあり方2011
- Author(s)
  清野裕
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] Incretin-Based Drugs ; Potential and Problems in Asian Countries4th Asian Islet Biology and Incretin Study Group(AIBIS) Symposium2011
- Author(s)
  矢部大介、清野裕
- Organizer
  4th Asian Islet Biology and Incretin Study Group(AIBIS) Symposium
- Place of Presentation
  北京、中国
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] Clinical Implication of Incretin Treatment in Asian type 2 Diabetes2011
- Author(s)
  清野裕
- Organizer
  3rd AASD Plenary Lecture
- Place of Presentation
  北京(中国)
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] 日本人2型糖尿病患者にインクレチン関連薬の有用性-日本人のインクレチン分泌と実臨床での効果を踏まえて2011
- Author(s)
  矢部大介、清野裕
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] 糖尿病専門診療のあり方2011
- Author(s)
  清野裕
- Organizer
  日本糖尿病学会年次学術集会Symposium 16
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] GLP-1アナログによるAkitaマウスの小胞体ストレス減少効果2009
- Author(s)
  山根俊介、浜本芳之、原田範雄、豊田健太郎、清野裕、稲垣暢也
- Organizer
  第5回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] LP-1アナログによるAkitaマウスの小胞体ストレス減少効果2009
- Author(s)
  山根俊介、原田範雄、山田千積、豊田健太郎、浜本芳之、清野裕、稲垣暢也
- Organizer
  第5回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-21591132
[Presentation] GLP-1 receptor activation attenuates beta cell damage in Akita mice2008
- Author(s)
  山根俊介、浜本芳之、原田範雄、豊田健太郎、清野裕、稲垣暢也
- Organizer
  第44回欧州糖尿病学会
- Place of Presentation
  ローマ、イタリア
- Year and Date
  2008-09-09
- Data Source
  KAKENHI-PROJECT-19591046
[Presentation] GLP-1シグナルの増強はAkitaマウスの膵β細胞障害を抑制する2008
- Author(s)
  山根俊介、原田範雄、山田千積、豊田健太郎、浜本芳之、清野裕、稲垣暢也
- Organizer
  第51回日本糖尿病学会年次学術集会
- Year and Date
  2008-05-23
- Data Source
  KAKENHI-PROJECT-19591046

1. ISHIDA Hitoshi (80212893)

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2. IMURA Hiroo (10025570)

# of Collaborated Projects: 10 results

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3. TSUDA Kinsuke (10180001)

# of Collaborated Projects: 5 results

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4. YAMADA Yuichiro (60283610)

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5. 福田善弘 (50127130)

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6. 森徹 (40026894)

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7. NAKAI Yoshikatsu (10115892)

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8. SEINO Susumu (80236067)

# of Collaborated Projects: 3 results

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14. HORIKOSHI Hiroyoshi

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15. NAKAO Kazuwa (00172263)

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16. OKA Yoshitomo (70175256)

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17. HAMAMOTO Yoshiyuki (50390787)

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18. TOYODA Kentarou (00447971)

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# of Collaborated Products: 9 results
19. HOSOKAWA Masaya (50343231)

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22. YAMANE Syunsuke

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24. KADAWAKI Takashi (30185889)

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26. TAKEDA Jun (40270855)

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27. MATSUMOTO Shinichi (70359834)

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28. TANAKA Koichi (20115877)

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29. FUJIMOTO Yasuhiro (80335281)

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30. MAEKAWA Taira (80229286)

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31. KATA Yuzuru (90030965)

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32. Higashiyama Hiroko (20071160)

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33. 上野川修一 (50011945)

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34. 菅野道広 (70038181)

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35. 奥山治美 (90080176)

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36. 吉川正明 (50026572)

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37. 杉本悦郎 (50026522)

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38. 筬島豊 (00038184)

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39. 大久保一良 (00005612)

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42. JOHNSON John H

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43. FUJIMOTO Wilfred Y

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44. CHARLES F BU

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45. GRAEME I BEL

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46. BELL Graeme I

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47. BURANT Charles

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48. BURANT Charl

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49. BELL Graeme

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50. NEWGARD Chri

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51. NEWGARD Christopher B

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52. 久保田章

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54. HARADA Norio

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55. 成瀬桂子

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56. 中村二郎

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SEINO Yutaka 清野 裕

清野 裕 セイノ ユタカ

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Investigation for intracellular mechanisms of pancreatic-cell proliferation and anti-apoptotic effect of incretinPrincipal Investigator

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Effect of incretin on beta cell proliferation and prevention of diabetesPrincipal Investigator

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Gut-peptides regulate metabolism in whole body.Principal Investigator

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Analysis of transcriptional network in pancreatic β-cellsPrincipal Investigator

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ソマトスタチンによる腫瘍増殖抑制機構の解析Principal Investigator

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Characterizetion of glucose-induced signal transduction and its impairment in type 2 diabetePrincipal Investigator

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ソマトスタチンによる抗腫瘍効果の分子機構に関する研究Principal Investigator

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Development of new hypoglycemic agents with a novel insulinotropic mechanism and their clinical appkicatiorPrincipal Investigator

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SEINO Yutaka 清野裕

清野裕セイノユタカ