Hirai Syu-ichi 平井秀一

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HIRAI Syu-ichi 平井秀一

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Researcher Number	80228759
External Links
Affiliation (Current)	2025: 和歌山県立医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2014 – 2022: 和歌山県立医科大学, 医学部, 教授 2012: 和歌山県立医科大学, 医学部, 教授 2006 – 2011: 横浜市立大学, 医学研究科, 准教授 2006: Yokohama City thiiversity Graduate School of Medical Science, Department of Molecular Biology, Associate Professor, 医学研究科, 準教授 2005: 横浜市立大学, 大学院・医学研究科, 準教授 … More 2003 – 2005: Yokohama City University, School of Medicine, Associate Professor, 大学院・医学研究科, 助教授 2004: 横浜市立大学, 医学研究科, 助教授 1998 – 2002: Yokohama City University School of Medicine, Department of Molecular Biology, As, 医学部, 助教授 1994 – 1997: YCU Sch.Med.Dept.Mol.Bio.lecturer, 医学部, 講師 1992 – 1994: YCU Sch. Med. Dept. Mol. Bio. Assistant Professor, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Molecular biology / Molecular biology / Biological Sciences Except Principal Investigator General medical chemistry / Functional biochemistry / General medical chemistry / Basic Section 56060:Ophthalmology-related / Pathological medical chemistry / Cell biology
Keywords	Principal Investigator JNK / シグナル伝達 / MLK / MAPキナーゼ / AP1 / MUK / MAP kinase / signal transduction / 神経 / 大脳皮質 … More / 微小管 / DLK / PKC / Jun / 細胞移動 / neurogenesis / MBIP / molecular biology / 神経軸索 / キネシン / JIP / 輸送 / VHL / プロテインキナーゼC / axon / cell migration / brain / 発生 / 軸索形成 / 脳・神経 / 生体分子 / neuron / migration / cortex / 神経細胞 / 細胞極性 / ノックアウトマウス / cerebral cortex / leucine zipper / Two-hybrid / 神経分化 / ロイシンジッパー / MJK / リン酸化酵素 / 分子生物学 / transcription factor / protein kinase C / 転写因子 / 変性 / 再生 / 中枢神経 / 軸索再生 / 軸索 / Kinesin / 細胞内輸送 / Kinesin-1 / JIP1 / 機能 / 生体高分子構造 / contact inhibition / 腎がん / がん抑制遺伝子 / 細胞増殖 / プロテアソーム / ユビキチン / 転写制御 / TRE / Ras / ras / jun … More Except Principal Investigator ジアシルグリセロール / 転写活性化 / ホルボールエステル / PKC関連酵素 / プロテインキナーゼC / ATPase / mRNA surveillance / mRNA degradation / ATPアーゼ / リン脂質キナーゼ / mRNA分離 / RNAヘリカーゼ / プロテインキナーゼ / p53 / mRNAサーベイランス / ナンセンス変異 / JNK / ストレス応答 / RNA helicase / PIK remated protein kinase / protein kinase / P53 / nonsense mutation / PAR-6 / PAR-3 / ASIP / aPKC / キナーゼ / マップキナーゼ / 神経麻痺生角膜症 / TRPチャネル / 角膜上皮創傷治癒 / マトリセルラー蛋白質 / 角膜創傷治癒 / テネイシンX / nonsense mutaion / RNA helices / PIK remitted protein kinas / protein kinas / NMD / ADPアーゼ / リン脂質類似キナーゼ / mRNA分解 / epithelia / polarity / asymmetric cell division / C.elegans / 上皮 / 極性 / 非対称分裂 / 線虫 / stabilization / binding protein / mRNA induction / MAP kinase / stress response / 安定化 / 結合タンパク質 / mRNA誘導 / TPA-response element / TPA / PKC binding proteins / PKC substrates / tumor promoters / diacylglyverol / phospholipids / protein kinase C / Diacylglycerol / Kinase / Transcriptional Activation / Phorbol esters / PKC-related enzymes / Protein kinase C / 上皮組織 / キナ-ゼ / ホルボ-ルエステル / プロテインキナ-ゼC / 発生・文化 / 発生・分化 / 細胞・組織 / 分化 / 発生 / シグナル伝達 / 組織 / 細胞 / 再生医学 / 癌 / rac / PAK / SEK / SAPK / DNA合成 / 血清飢餓 / プロテインキナーゼC結合タンパク質 / ホスホリパーゼC / PI3キナーゼ / メタロプロティナーゼ / NFkB / S6キナーゼ / ブロテアーゼ / 転写因子 / カルパイン Less

Establishment of a Novel Therapeutic Strategy for Neurotrophic Keratopathy by Targeting the Tenesin X-TRP Channel System
- Principal Investigator
  
  Sumioka Takayoshi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Wakayama Medical University
Degeneration- and regeneration-inducing mechanism in neuronal axonPrincipal Investigator
- Principal Investigator
  
  Hirai Syu-ichi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Wakayama Medical University
Molecular mechanisms of the polarity-regulating signaling
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cell biology
- Research Institution
  Yokohama City University
Regulatory mechanism for intracellular transport depending on the DLK-JNK signaling pathwayPrincipal Investigator
- Principal Investigator
  
  HIRAI Syu-ichi
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Wakayama Medical University
  Yokohama City University
Regulatory mechanism of intracellular transport by DLK-JNK complexPrincipal Investigator
- Principal Investigator
  
  HIRAI Syu-ichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
Molecular mechanism of mammalian mRNA surveillance
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Yokohama City University
Molecular mechanism of intracellular trafficking by MUK-JNK pathwayPrincipal Investigator
- Principal Investigator
  
  HIRAI Syu-ichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
Molecular mechanism of mammalian mRNA surveillance
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Yokohama City University Graduate School of Medical Science
Regulation mechanism of a signal transduction by MUK-JNK pathway.Principal Investigator
- Principal Investigator
  
  HIRAI Syu-ichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
細胞接着による増殖抑制におけるVHL癌抑制遺伝子産物の機能Principal Investigator
- Principal Investigator
  
  平井秀一
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Molecular mechanism of mammalian mRNA surveillance
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Yokohama City University
がん抑制遺伝子VHLによるシグナル伝達調節機構Principal Investigator
- Principal Investigator
  
  平井秀一
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Analyses of the universal molecular machinary involved in cell polarization
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Functional biochemistry
- Research Institution
  Yokohama City University School of Medicine
The regulation of signal transduction by JNK activators, MUK and MST.Principal Investigator
- Principal Investigator
  
  HIRAI Syu-ichi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
Intra-cellular signaling cascades involved in cellular stress responses
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Yokohama City University School of Medicine
Regulation mechanism of a JNK/SAPK-activating protein kinase MST,a memher of MLK family.Principal Investigator
- Principal Investigator
  
  HIRAI Syu-ichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
細胞接着と細胞増殖におけるC-キナーゼの役割
- Principal Investigator
  
  大野茂男
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
新規キナーゼMUK1,MUK3の関与するキナーゼカスケードの解明
- Principal Investigator
  
  長田真一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
Identification of PKC substrate involved in the activatoin of AP1/JunPrincipal Investigator
- Principal Investigator
  
  HIRAI Syu-ichi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
転写因子AP1の活性化に関与するプロテインキナーゼCの基質の同定Principal Investigator
- Principal Investigator
  
  平井秀一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
細胞増殖におけるプロテインキナーゼC群の機能の分子生物学的解析
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
転写因子APIの活性化に関与するプロテインキナーゼCの基質の固定Principal Investigator
- Principal Investigator
  
  平井秀一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University
Action mechanisms of dominant negative protein kinase C ; identification of PKC binding proteins
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Yokohama City University
転写因子の代謝と転写制御
- Principal Investigator
  
  鈴木紘一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
Identification and Functional Analysis of Protein Kinase C-Related Gene
- Principal Investigator
  
  OHNO Shigeo
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  YOKOHAMA CITY UNIVERSITY SCHOOL OF MEDICINE

[Journal Article] Sensory nerve supports epithelial stem cell function in healing of corneal epithelium in mice: the role of trigeminal nerve transient receptor potential vanilloid 4.2019
- Author(s)
  Okada Y, Sumioka T, Ichikawa K, Sano H, Nambu A, Kobayashi K, Uchida K, Suzuki Y, Tominaga M, Reinach PS, Hirai SI, Jester JV, Miyajima M, Shirai K, Iwanishi H, Kao WW, Liu CY, Saika S.
- Journal Title
  
  Lab Invest.
  
  Volume: 99(2) Issue: 2 Pages: 210-230
- DOI
  10.1038/s41374-018-0118-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11464, KAKENHI-PROJECT-18K09419, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-ORGANIZER-15H05871, KAKENHI-PUBLICLY-17H05590, KAKENHI-PROJECT-26250009, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-15K10878, KAKENHI-PROJECT-16K01968, KAKENHI-PLANNED-15H05873
[Journal Article] A role for DLK in microtubule reorganization to the cell periphery and in the maintenance of desmosomal and tight junction integrity.2017
- Author(s)
  Simard-Bisson C, Bidoggia J, Larouche D, Guerin SL, Blouin R, Hirai S, Germain L.
- Journal Title
  
  J Invest Dermatol
  
  Volume: 137 Issue: 1 Pages: 132-141
- DOI
  10.1016/j.jid.2016.07.035
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440008
[Journal Article] EphA4 Regulates the Balance between Self-Renewal and Differentiation of Radial Glial Cells and Intermediate Neuronal Precursors in Cooperation with FGF Signaling2015
- Author(s)
  Chen Q, Arai D, Kawakami K, Sawada T, Xuefeng Jing (京　雪楓), Miyajima M, Hirai S, Sakaguchi K
- Journal Title
  
  PLoS One
  
  Volume: 1 Issue: 5 Pages: 1-24
- DOI
  10.1371/journal.pone.0126942
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461394, KAKENHI-PROJECT-26440008
[Journal Article] The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain.2013
- Author(s)
  Satake T, et al.
- Journal Title
  
  BMC Cell Biol
  
  Volume: 14 Issue: 1 Pages: 12-12
- DOI
  10.1186/1471-2121-14-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570184, KAKENHI-PROJECT-22247030, KAKENHI-PLANNED-23112003
[Journal Article] Functional genomic screening identifies dual leucine zipper kinase as a key2013
- Author(s)
  D.S.Welsbie,Z.Yang,Y.Ge,K.L.Mitchell,X.Zhou,S.E.Martin,C.A.Berlinicke,L.HacklerJr,J.Fuller,J.Fu,L.H.Cao,B.Han,D.Auld,T.Xue,S.Hirai,L.Germain,C.SimardBisson,R.Blouin,J.V.Nguyen,C.H.Davis,R.A.Enke,S.L.Boye,S.L.Merbs,N.Marsh-Armstrong,W.W.Hauswirth,A.Diantonio,R.W.Nickells,J.Inglese,J.Hanes,K.W.Yau,H.A.Quigley,D.J.Zack
- Journal Title
  
  mediator of retinal ganglion cell death
  
  Volume: 110 Pages: 4045-4050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570184
[Journal Article] the interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain2013
- Author(s)
  T.Satake,K.Ohtsuki,Y.Banba,J.Suenaga,H.Hirano,Y.Yamanaka,S.Ohno,S.Hirai
- Journal Title
  
  BMC Cell Biol
  
  Volume: 14 Pages: 12-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570184
[Journal Article] 軸索形成に必要なDLK-JNK経路と微小管制御2012
- Author(s)
  平井秀一
- Journal Title
  
  生体の科学
  
  Volume: 63 Pages: 183-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570184
[Journal Article] Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the DLK-JNK pathway2011
- Author(s)
  Hirai S-I, Banba Y, Satake T and Ohno S:
- Journal Title
  
  J. Neuroscience
  
  Volume: 3 Issue: 17 Pages: 6468-6480
- DOI
  10.1523/jneurosci.5038-10.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247030
[Journal Article] Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth2011
- Author(s)
  K.Hayashi,A.Suzuki,S.Hirai,Y.Kurihara,C.C.Hoogenraad,S.
- Journal Title
  
  J。Neurosci
  
  Volume: 31 Pages: 12094-12103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570184
[Journal Article] Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the Dual Leucine zipper Kinase-c-Jun N-terminal Kinase pathway2011
- Author(s)
  S.Hirai,Y.Banba,T.Satake,S.Ohno
- Journal Title
  
  J.Neurosci
  
  Volume: 31 Pages: 6468-6480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570184
[Journal Article] Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth.2011
- Author(s)
  Hayashi K, Suzuki A, Hirai S, Kurihara Y, Hoogenraad CC, Ohno S
- Journal Title
  
  J Neurosci
  
  Volume: 31(34) Pages: 12094-12103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247030
[Journal Article] Axon Formation in Neocortical Neurons Depends on Stage-Specific Regulation of Microtubule Stability by the Dual Leucine Zipper Kinase-c-Jun N-terminal Kinase Pathway.2011
- Author(s)
  Hirai S, Banba Y, Satake T, Ohno S
- Journal Title
  
  J Neuroscience
  
  Volume: 31(17) Pages: 6468-6480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247030
[Journal Article] Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth2011
- Author(s)
  Hayashi K, Suzuki A, Hirai S, Kurihara Y, Hoogenraad CC, Ohno S
- Journal Title
  
  J. Neurosci.
  
  Volume: 31 Issue: 34 Pages: 12094-12103
- DOI
  10.1523/jneurosci.0751-11.2011
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116004, KAKENHI-PROJECT-21570184, KAKENHI-PROJECT-22247030
[Journal Article] Axon Formation in Neocortical Neurons Depends on Stage-Specific Regulation of Microtubule Stability by the Dual Leucine Zipper Kinase-c-Jun N-Terminal Kinase Pathway.2011
- Author(s)
  Syu-ichi Hirai, et al.
- Journal Title
  
  J.Neurosci.
  
  Volume: 31 Pages: 6468-6480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570184
[Journal Article] Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the DLK-JNK pathway.2011
- Author(s)
  Hirai S-I, Banba Y, Satake T, Ohno S
- Journal Title
  
  J. Neuroscience
  
  Volume: 31(17) Pages: 6468-6480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247030
[Journal Article] JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration2010
- Author(s)
  J.Jin,H.Suzuki,S.Hirai,K.Mikoshiba,T.Ohshima
- Journal Title
  
  Dev.Neurobiol
  
  Volume: 70 Pages: 929-942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570184
[Journal Article] Dominant-negative mutations in a-II spectrin cause West syndrome with severe cerebral hypomyelination2010
- Author(s)
  H.Saitsu,J.Tohyama,T.Kumada,K.Egawa,K.Hamada,I.Okada,T.Mizuguchi,H.Osaka,shR.Miyata,T.Furukawa,K.Haginoya,H.Hoshino,T.Goto,Y.Hachiya,T.Yamagata,S.Saitoh,T.Nagai,K.Niiyama,A.Nishimura,N.Miyake.M.Komada,K.Hayashi,S.Hirai,K.Ogata,M.Kato,A.Fukuda,N.Matsumoto
- Journal Title
  
  spastic quadriplegia, and developmental delay
  
  Volume: 86 Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570184
[Journal Article] がん細胞を知る -分子レベルで見た正常細胞との違い-2010
- Author(s)
  平井秀一
- Journal Title
  
  Medical Technology 38
  
  Pages: 503-506
- Data Source
  KAKENHI-PROJECT-21570184
[Journal Article] がん細胞を知る-分子レベルでみた正常細胞との違い-2010
- Author(s)
  平井秀一
- Journal Title
  
  Medical Technology
  
  Volume: 38 Pages: 503-506
- Data Source
  KAKENHI-PROJECT-21570184
[Journal Article] EMTにおける細胞極性の転換2008
- Author(s)
  平井秀一、大野茂男
- Journal Title
  
  細胞工学 27
  
  Pages: 326-331
- Data Source
  KAKENHI-PROJECT-19570167
[Journal Article] EMTにおける細胞極性の転換2008
- Author(s)
  平井秀一, 大野茂男
- Journal Title
  
  細胞工学 27
  
  Pages: 326-331
- Data Source
  KAKENHI-PROJECT-19570167
[Journal Article] De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy2008
- Author(s)
  H. Saitsu, M. Kato, T. Mizuguchi, K. Hamada, H. Osaka, J. Tohyama, K. Uruno, S. Kumada, K. Nishiyama, A. Nishimura, I. Okada, Y. Yoshimura, S.-i. Hirai, T. Kumada, K. Hayasaka, A. Fukuda, K. Ogata, N. Matsumoto
- Journal Title
  
  Nat. Genet. 40
  
  Pages: 782-788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570167
[Journal Article] Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages2007
- Author(s)
  W. Zhao, T. Hirose, M. Ishikawa, Y. Oshima, S.-i. Hirai, S. Ohno, H. Taniguchi
- Journal Title
  
  Biochem Biophys Res Commun. 352
  
  Pages: 84-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570167
[Journal Article] Developmental changes in the expression pattern of the JNK activator kinase MUK/DLK/ZPK and active JNK in the mouse cerebellum.2006
- Author(s)
  J.Suenaga, D.F.Cui, I.Yamamoto, S.Ohno, S.-i.Hirai.
- Journal Title
  
  Cell Tissue Res. 325
  
  Pages: 189-195
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570146
[Journal Article] Inactivation of aPKCl results in a loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex.2006
- Author(s)
  F.Imai, S.-i.Hirai, K.Akimoto, H.Koyama, T.Miyata, M.Ogawa, S.Noguchi, T.Sasaoka, T.Noda, S.Ohno.
- Journal Title
  
  Development 133
  
  Pages: 1735-1744
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570146
[Journal Article] The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex.2006
- Author(s)
  Hirai, S. et al.
- Journal Title
  
  J. Neurosci. 26
  
  Pages: 11992-12002
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570146
[Journal Article] The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex.2006
- Author(s)
  S.-i.Hirai, D.F.Cui, T.Miyata, M.Ogawa, H.Kiyonari, Y.Suda, S.Aizawa, Y.Banba, S.Ohno.
- Journal Title
  
  J.Neurosci. 26
  
  Pages: 11992-12002
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570146
[Journal Article] Expression of MUK/DLK/ ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo.2005
- Author(s)
  S.-i.Hirai, A.Kawaguchi, J.Suenaga, M.Ono, D.F.Cui, S.Ohno.
- Journal Title
  
  Gene Expr.Patterns 5
  
  Pages: 517-523
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570146
[Journal Article] Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo.2005
- Author(s)
  Hirai, S. et al.
- Journal Title
  
  Gene Expression Patterns 5
  
  Pages: 517-523
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570146
[Journal Article] Expression of MUK/DLK/ZPK, and activator of the JNK pathway, in the nervous systems of the developing mouse embryo.2005
- Author(s)
  Hirai S. et al.
- Journal Title
  
  Gene Expression Patterns 5
  
  Pages: 517-523
- Data Source
  KAKENHI-PROJECT-17570146
[Journal Article] Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease2004
- Author(s)
  Usuki, F., Yamashita, A., Higuchi, I., Ohnishi, T., Shiraishi, T., Osame, M., Ohno, S.
- Journal Title
  
  Annals of Neurology 55
  
  Pages: 740-744
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209013
[Journal Article] Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease.2004
- Author(s)
  Usuki F, Yamashita A, Higuchi I, Ohnishi T, Shiraishi T, Osame M, Ohno S.
- Journal Title
  
  Ann Neurol. 55(5)
  
  Pages: 740-744
- Data Source
  KAKENHI-PROJECT-15209013
[Journal Article] Inhibition of nonsense-mediated mRNA decay rescues the phenotype in Ullrich's disease.2004
- Author(s)
  Usuki F, Yamashita A, Higuchi I, Ohnishi T, Shiraishi T, Osame M, Ohno S
- Journal Title
  
  Ann.Neurol. 55(5)
  
  Pages: 740-744
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209013
[Journal Article] Loss of von Hippel-Lindau protein causes cell density-dependent deregulation of CyclinD1 expression through Hypoxia-inducible factor.2003
- Author(s)
  Baba M, Hirai S-I, Yamada-Okabe H, Hamada K, Tabuchi H, Kobayashi K, Kondo K, Yoshida M, Yamashita A, Kishida T, Nakaigawa N, Nagashima Y, Kubota Y, Yao M, Ohno S
- Journal Title
  
  Oncogene 22(18)
  
  Pages: 2728-2738
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209013
[Journal Article] Loss of von Hippel-Lindau protein causes cell density-dependent deregulation of CyclinD1 expression through Hypoxia-inducible factor2003
- Author(s)
  Baba, M., Hirai, S-I., Yamada-Okabe, H., Hamada, K., Tabuchi, H., Kobayashi, K., Kondo, K., Yoshida, M., Yamashita, A., Kishida, T., Nakaigawa, N., Nagashima, Y., Kubota, Y., Yao, M., Ohno, S.
- Journal Title
  
  Oncogene 22
  
  Pages: 2728-2739
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209013
[Presentation] DLK and JNK regulate the protein level of SCG10/stathmin-2 in cortical neurons.2017
- Author(s)
  Hisashi Yamasaki, Masayasu Miyajima, Shigeo Ohno, Syu-ichi Hirai
- Organizer
  2017年度生命科学系学会合同年次大会 ConBio2017
- Data Source
  KAKENHI-PROJECT-26440008
[Presentation] DLK-dependent JNK activation facilitates the axon formation in cortical neurons.2017
- Author(s)
  平井秀一
- Organizer
  第60回日本神経化学回大会
- Invited
- Data Source
  KAKENHI-PROJECT-26440008
[Presentation] 軸索と樹状突起はその伸長過程において異なる量の微小管制御因子SCG10を要求する2016
- Author(s)
  山﨑尚、宮嶋正康、大野茂男、平井秀一
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26440008
[Presentation] DLK-JNK pathway regulates the timing for axon formation and dendrite outgrowth2015
- Author(s)
  Yamasaki H, Miyajima M, Ohno S, Hirai S
- Organizer
  BMB2015
- Place of Presentation
  Kobe, Japan
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26440008
[Presentation] マウスでのDLK-JNK経路に依存した軸索形成2014
- Author(s)
  平井秀一
- Organizer
  第５回　神経科学と構造生物学の融合研究会
- Place of Presentation
  大阪大学蛋白質研究所（大阪府吹田市）
- Year and Date
  2014-12-05
- Invited
- Data Source
  KAKENHI-PROJECT-26440008
[Presentation] JNK reduces SCG10 protein level to regulate axon formation.2012
- Author(s)
  Hirai S, Ohno S
- Organizer
  2012 Annual Meeting of The American Society for Cell Biology
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-21570184
[Presentation] JNK facilitates the formation of epithelial cell sheet2012
- Author(s)
  Furukawa K, Ohno S, Hirai S
- Organizer
  第33回日本分子生物学会年会、第83回日本生化学会合同大会
- Place of Presentation
  福岡
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-21570184
[Presentation] JNK reduces SCG10 protein level to regulate axon formation2012
- Author(s)
  Hirai S,Ohno
- Organizer
  2012 Annual Meeting of The American Society for Cell Biology
- Place of Presentation
  San Francisco, USA
- Year and Date
  2012-12-19
- Data Source
  KAKENHI-PROJECT-21570184
[Presentation] Molecular mechanism supporting transitions in cell polarity during neuronal development2011
- Author(s)
  Hirai S
- Organizer
  The 34thAnnual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Yokohama
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-21570184
[Presentation] Molecular mechanism supporting transitions in cell polarity during Neuronal development2011
- Author(s)
  Syu-ichi Hirai
- Organizer
  The 34^<th> Annual Meeting of the Molecular Biology Society of Japan (3S3pI-5)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-21570184
[Presentation] Axon formation in neocortical neurons depends on the stage-specific stabilization of microtubules by DLK-JNK pathway.2010
- Author(s)
  Hirai S-I, Banba Y, Satake T, Ohno S
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22247030
[Presentation] Regulatory mechanism of kinesin-1 motor activity through JIP1.2010
- Author(s)
  Satake T, Hirano H, Yamanaka Y, Ohno S, Hirai S-I
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22247030
[Presentation] egulatory mechanism for Kinesin-1 motor activity through JIP12010
- Author(s)
  Satake T, Banba Y, Ohno S, Hirai S
- Organizer
  第33回日本分子生物学会年会、第83回日本生化学会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21570184
[Presentation] Axon formation in neocortical neurons depends on the stage-specific stabilization of microtubules by DLK-JNK pathway2010
- Author(s)
  Hirai S, Banba Y, Satake T, Ohno S
- Organizer
  第33回日本分子生物学会年会,第83回日本生化学会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21570184
[Presentation] 細胞極性によるHippo経路の抑制がマウス着床前胚における位置依存的な細胞分化をつかさどる2010
- Author(s)
  平手良和, 平原志乃, 井上健一, 中尾和貴, 鈴木厚, 秋本和憲, 大野茂男, 平井孝明, 千田和広, Marikawa Y, Vernadeth A, 佐々木洋
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(ポスター発表)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22247030
[Presentation] 細胞極性によるHippo経路の抑制がマウス着床前胚における位置依存的な細胞分化をつかさどる2010
- Author(s)
  平手良和, 平原志乃, 井上健一, 中尾和貴, 鈴木厚, 秋本和憲, 大野茂男, 平井孝明, 千田和広, Marikawa Y, Vernadeth A, 佐々木洋
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(口頭発表)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22247030
[Presentation] Axon formation in neocortical neurons depends on the stage-specific stabilization of microtubules by DLK-JNK pathway.2010
- Author(s)
  Syu-ichi Hirai, et.al.
- Organizer
  第33回日本分子生物学会年会、第83回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21570184
[Presentation] egulatory mechanism for Kinesin-1 motor activity through JIP12009
- Author(s)
  Satake T, Banba Y, Ohno S, Hirai S
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会合同大会
- Place of Presentation
  横浜
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21570184
[Presentation] JNK as a coordinator of microtubule modulation facilitating axon formation2009
- Author(s)
  Syu-ichi Hirai, 他3名
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会合同大会
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21570184
[Presentation] 大脳皮質神経発生に関わる二つのJNKシグナル経路2008
- Author(s)
  平井秀一、番場由美、佐竹智子、大野茂男
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570167
[Presentation] Kinesin-1とJIP1の結合制御機構2008
- Author(s)
  佐竹智子, 大野茂男, 平井秀一
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会合同大会
- Place of Presentation
  神戸ポートピア
- Data Source
  KAKENHI-PROJECT-19570167
[Presentation] 大脳皮質神経発生に関わる二つのJNKシグナル経路2008
- Author(s)
  平井秀一, 番場由美, 佐竹智子, 大野茂男
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会合同大会
- Place of Presentation
  神戸ポートピア
- Data Source
  KAKENHI-PROJECT-19570167
[Presentation] Kinesin-1とJIP1の結合制御機構2008
- Author(s)
  佐竹智子、大野茂男、平井秀一
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570167
[Presentation] DLK、JNKによる神経細胞軸索形成の制御2007
- Author(s)
  平井秀一, 他
- Organizer
  第30回日本分子生物学会年会第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19570167
[Presentation] リン酸化により活性化されたJNKが選択的にJIP-1と結合する2007
- Author(s)
  大槻香林, 大野茂男, 平井秀一
- Organizer
  第30回日本分子生物学会年会第80回日本生化学会大会合同大会(BMB2007)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570167
[Presentation] DLK、JNKによる神経細胞軸索形成の制御2007
- Author(s)
  平井秀一, 番場由美, 大槻香林、佐竹智子、大野茂男
- Organizer
  第30回日本分子生物学会年会第80回日本生化学会大会合同大会(BMB2007)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570167
[Presentation] JNK依存的軸索形成における微小管制御因子SCG10の役割
- Author(s)
  山﨑尚、大野茂男、平井秀一
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26440008
[Presentation] Maintenance of Dendritic Spine Morphology by PAR1b through Regulation of Microtubule Dynamics.
- Author(s)
  林健二, 鈴木厚, 平井秀一, 栗原靖之, Casper C Hoogenraad, 大野茂男
- Organizer
  第63回日本細胞生物学会大会
- Place of Presentation
  北海道大学　クラーク会館、学術交流会館(北海道)
- Data Source
  KAKENHI-PROJECT-22247030
[Presentation] JNK Facilitates the Formation of Epithelial Cell Sheet.
- Author(s)
  Furukawa K, Ohno S, Hirai S-I
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡（福岡県）
- Data Source
  KAKENHI-PROJECT-22247030

1. OHNO Shigeo (10142027)

# of Collaborated Projects: 10 results

# of Collaborated Products: 15 results
2. MIZUNO Keiko (90221803)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. SUZUKI Atsushi (00264606)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
4. AKIMOTO Kazunori (70285104)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
5. OSADA Shinichi (00244484)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. 執印太郎 (80179019)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YAMASHITA Akio (20405020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HIROSE Tomonori (20381668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKAYA Masa-aki (70422095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SASAKI Kazunori (50438131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. YAMASAKI Hisashi (20212285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. Sumioka Takayoshi (40433362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 鈴木紘一 (80011948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 反町洋之 (10211327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 富岡茂雄 (90159054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 秋田朗子 (40124432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 雑賀司珠也 (40254544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 岡田由香 (50264891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 山中修 (50254545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 松本健一 (30202328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 小出隆規 (70322253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. MIYAJIMA Masayasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. SAWADA Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 坂口和成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 荊雪楓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 新井大貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirai Syu-ichi 平井 秀一

HIRAI Syu-ichi 平井 秀一

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Degeneration- and regeneration-inducing mechanism in neuronal axonPrincipal Investigator

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Regulatory mechanism for intracellular transport depending on the DLK-JNK signaling pathwayPrincipal Investigator

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Regulatory mechanism of intracellular transport by DLK-JNK complexPrincipal Investigator

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Molecular mechanism of intracellular trafficking by MUK-JNK pathwayPrincipal Investigator

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Regulation mechanism of a signal transduction by MUK-JNK pathway.Principal Investigator

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細胞接着による増殖抑制におけるVHL癌抑制遺伝子産物の機能Principal Investigator

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がん抑制遺伝子VHLによるシグナル伝達調節機構Principal Investigator

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The regulation of signal transduction by JNK activators, MUK and MST.Principal Investigator

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Hirai Syu-ichi 平井秀一

HIRAI Syu-ichi 平井秀一