KUBOTA Hiroshi 久保田浩司

… Alternative Names

久保田浩司クボタヒロシ

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Researcher Number	80263094
Other IDs
Affiliation (Current)	2025: 北里大学, 獣医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 北里大学, 獣医学部, 教授 2012 – 2014: 北里大学, 獣医学部, 教授 2008 – 2011: Kitasato University, 獣医学部, 准教授 1995: Kyoto University, Faculty of Medicine Asistant, 医学研究科, 助手 1994: 京都大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Applied animal science / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Integrative animal science Except Principal Investigator Basic Section 42040:Laboratory animal science-related / Immunology
Keywords	Principal Investigator 精原幹細胞 / 精子形成 / バイオテクノロジー / 生殖 / 分化・発生 / 幹細胞 / 生殖幹細胞 / ウシ / 機能発現クローニング / 異種移植 … More / 人工幹細胞 / 初期化 / 自己複製 / 増殖因子 … More Except Principal Investigator Rap1 / がん抑制遺伝子 / ロイシンジッパー / 低分子G蛋白 / GTPase活性化蛋白 / 核内蛋白 / ブタ / トランスジェニックマウス / 精細管内移植アッセイ / セルトリ細胞 / KITL / ブタ精原幹細胞 / 精子形成 / 異種移植 / 精原幹細胞 / chusmosomal mapping / proliferation / baculovirus / cell cycle / GTPase activating protein / small G protein / lymphocutes / 細胞同期 / 細胞分裂 / リンパ球活性化 / サイトカイン / シグナル伝達 / がん遺伝子 / G蛋白活性化蛋白 / 染色体マッピング / 細胞増殖 / バキュロウイルス / 細胞周期 / 低分子量G蛋白 / リンパ球 / leucine zipper motif / PEST / RCC-1 system / Ran / cell cycle progression / processing / nuclear protein / Ran binding / 第19染色体 / PEST配列 / プロセッシング / T細部亜群 / 個体発生 / 主要組織適合抗原 / T細胞レセプター / 胎生造血 / 髄外造血 / 4F2抗原 / 胎生癌細胞 / 胎児性抗原 / T細胞抗原レセプター Less

機能的スクリーニングによる種特異的精子形成誘導因子の同定Principal Investigator
- Principal Investigator
  
  久保田浩司
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Kitasato University
Development of spermatogonial stem cell xenotransplantation method using transgenic nude mice
- Principal Investigator
  
  Kakiuchi Kazue
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Kitasato University
Generation of induced spermatogonial stem cells by direct reprogrammingPrincipal Investigator
- Principal Investigator
  
  Kubota Hiroshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Integrative animal science
- Research Institution
  Kitasato University
Identification of regulatory molecules governing self-renewal versus differentiation of spermatogonial stem cellsPrincipal Investigator
- Principal Investigator
  
  Kubota Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  Kitasato University
Unraveling the molecular mechanisms of spermatogenesis using differentiation-deficient spermatogonial stem cellsPrincipal Investigator
- Principal Investigator
  
  KUBOTA Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied animal science
- Research Institution
  Kitasato University
MHC非拘束性T細胞の抗原レセプターと認識抗原の研究
- Principal Investigator
  
  湊長博
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Nuclear small G protein system involved in cell cycle.
- Principal Investigator
  
  MINATO Nagahiro
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
Molecular mechanisms for cell cycle control in the immune system
- Principal Investigator
  
  MINATO Nagahiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  KYOTO UNIVERSITY
造血組織に局在する新しいT細胞亜群の認識レパートリーの研究
- Principal Investigator
  
  MINATO Nagahiro
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University

All 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Cell-Surface DEAD-Box Polypeptide 4-Immunoreactive Cells and Gonocytes Are Two Distinct Populations in Postnatal Porcine Testes2014
- Author(s)
  Kakiuchi K, Tsuda A, Goto Y, Shimada T, Taniguchi K, Takagishi K, Kubota H
- Journal Title
  
  Biology of Reproduction
  
  Volume: 90 Issue: 4 Pages: 1-11
- DOI
  10.1095/biolreprod.113.114405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25660255, KAKENHI-PROJECT-23380168
[Journal Article] Cell-Surface DEAD-Box Polypeptide 4-Immunoreactive Cells and Gonocytes Are Two Distinct Populations in Postnatal Porcine Testes2014
- Author(s)
  Kazue Kakiuchi, Ayaka Tsuda, Yuki Goto, Takanori Shimada, Kazumi Taniguchi, Kiyohiko Takagishi, Hiroshi Kubota
- Journal Title
  
  Biology of Reproduction
  
  Volume: 90 Pages: 82-82
- Data Source
  KAKENHI-PROJECT-23380168
[Journal Article] Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties2011
- Author(s)
  Hiroshi Kubota, Xin Wu, Shaun M Goodyear, Mary R Avarbock, Ralph L Brinster
- Journal Title
  
  FASEB Journal
  
  Volume: 25 Pages: 2604-2614
- Data Source
  KAKENHI-PROJECT-23380168
[Journal Article] Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties2010
- Author(s)
  Kubota H, Wu X, Goodyear SM, Avarbock MR, Brinster RL
- Journal Title
  
  FASEB Journal in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580313
[Journal Article] In vivo and in vitro aging is detrimental to mouse spermatogonial stem cell function.2010
- Author(s)
  Schmidt JA, Abramowitz LK, Kubota H, Wu X, Niu Z, Avarbock MR, Tobias JW, Bartolomei MS, Brinster RL
- Journal Title
  
  Biology of Reproduction vol.84
  
  Pages: 698-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580313
[Journal Article] Involvement of a membrane skeletal protein, 4.1G, for Sertoli/germ cell interaction.2010
- Author(s)
  Terada N, Ohno N, Saitoh S, Saitoh Y, Komada M, Kubota H, Ohno S
- Journal Title
  
  Reproduction
  
  Volume: 139 Pages: 883-892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580313
[Journal Article] Involvement of a membrane skeletal protein, 4.1G, for Sertoli/germ cell interaction.2010
- Author(s)
  Terada N, Ohno N, Saitoh S, Saitoh Y, Komada M, Kubota H, Ohno S
- Journal Title
  
  Reproduction vol.139
  
  Pages: 883-892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580313
[Journal Article] Spermatogonial stem cells derived from infertile Wv/Wv mice self-renew in vitro and generate progeny following transplantation.2009
- Author(s)
  Kubota H, Avarbock MR, Schmidt JA, Brinster RL
- Journal Title
  
  Biology of Reproduction vol.81
  
  Pages: 293-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580313
[Journal Article] Spermatogonial stem cells derived from infertile Wv/Wv mice self-renew in vitro and generate progeny following transplantation.2009
- Author(s)
  Kubota H, Avarbock MR, Schmidt JA, Brinster RL
- Journal Title
  
  Biology of Reproduction 81
  
  Pages: 293-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580313
[Journal Article] Culture of Rodent Spermatogonial Stem Cells, Male Germline Stem Cells of the Postnatal Animal.2008
- Author(s)
  Kubota H, Brinster RL
- Journal Title
  
  Methods in Cell Biology vol.86
  
  Pages: 59-84
- Data Source
  KAKENHI-PROJECT-20580313
[Journal Article] Hepatic stem cells and hepatoblasts : identification isolation, and ex vivo maintenance.2008
- Author(s)
  Wauthier E, Schmelzer E, Turner W, Zhang L, Lecluyse E, Ruiz J, Turner R, Furth ME, Kubota H, Lozoya O, Barbier C, McClelland R, Yao HL, Moss N, Bruce A, Ludlow J, Reid LM
- Journal Title
  
  Methods in Cell Biology vol.86
  
  Pages: 137-225
- Data Source
  KAKENHI-PROJECT-20580313
[Journal Article] Culture of rodent spermatogonial stem cells male, gernmline stem cells of the postnatal animal.2008
- Author(s)
  Kubota H., et al.
- Journal Title
  
  Methods in Cell Biology 86
  
  Pages: 59-84
- Data Source
  KAKENHI-PROJECT-20580313
[Presentation] Proteomic profiling of nuclear proteins in mouse spermatogonial stem cells undergoing differentiation2013
- Author(s)
  Kazue Kakiuchi, Kiyohiko Takagishi, Hiroshi Kubota
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸ポートアイランド(兵庫)
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-23380168
[Presentation] Comparative nuclear proteomic analysis of stem spermatogonia and differentiating spermatogonia induced by retinoic acid2013
- Author(s)
  Kakiuchi K, Takagishi K, Kubota H.
- Organizer
  12th Human Proteome Organisation World Congress (HUPO 2013)
- Place of Presentation
  神奈川県　パシフィコ横浜
- Year and Date
  2013-09-14
- Data Source
  KAKENHI-PROJECT-23380168
[Presentation] Proteomic profiling of nuclear proteins in mouse spermatogonial stem cells undergoing differentiation2013
- Author(s)
  Kakiuchi K, Takagishi K, Kubota H.
- Organizer
  第36回　日本分子生物学会
- Place of Presentation
  兵庫県　神戸ポートアイランド
- Year and Date
  2013-12-03
- Data Source
  KAKENHI-PROJECT-23380168
[Presentation] Proteomic profiling of nuclear proteins in mouse spermatogonial stem cells undergoing differentiation2013
- Author(s)
  Kakiuchi K, Takagishi K, Kubota H
- Organizer
  第36回　日本分子生物学会
- Place of Presentation
  兵庫県　神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25660255
[Presentation] Comparative nuclear proteomic analysis of stem spermatogonia and differentiating spermatogonia induced by retinoic acid2013
- Author(s)
  Kazue Kakiuchi, Kiyohiko Takagishi, Hiroshi Kubota
- Organizer
  12th Human Proteome Organization World Congress (HUPO2013)
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2013-09-16
- Data Source
  KAKENHI-PROJECT-23380168
[Presentation] Comparative nuclear proteomic analysis of stem spermatogonia and differentiating spermatogonia induced by retinoic acid2013
- Author(s)
  Kakiuchi K, Takagishi K, Kubota H
- Organizer
  12th Human Proteome Organization World Congress (HUPO 2013)
- Place of Presentation
  神奈川県　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25660255
[Presentation] マウス精原幹細胞における核タンパク質のプロテオーム解析2012
- Author(s)
  垣内一恵, 高岸聖彦, 久保田浩司
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  マリンメッセ福岡(福岡)
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-23380168
[Presentation] 成熟培地への糖基質の添加がブタ卵丘細胞のヒアルロン酸合成に及ぼす影響2012
- Author(s)
  高岸聖彦, 小林君任, 垣内一恵, 久保田浩司
- Organizer
  第30回日本受精着床学会総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2012-08-30
- Data Source
  KAKENHI-PROJECT-23380168
[Presentation] 非齧歯類哺乳動物の精原幹細胞培養系2011
- Author(s)
  久保田浩司
- Organizer
  第104日本繁殖生物学会
- Place of Presentation
  いわて県民情報交流センター・アイーナ (岩手)
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-23380168
[Presentation] 分化不全精原幹細胞の自己複製と分化誘導2010
- Author(s)
  久保田浩司
- Organizer
  第51回日本哺乳動物卵子学会
- Place of Presentation
  朱鷺メッセ(新潟)
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-20580313
[Presentation] 分化不全精原幹細胞の自己複製と分化誘導2010
- Author(s)
  久保田浩司
- Organizer
  第51回日本哺乳動物卵子学会
- Place of Presentation
  朱鷺メッセ(新潟県)
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-20580313
[Presentation] 精原幹細胞の自己複製と分化の制御2009
- Author(s)
  久保田浩司
- Organizer
  第33回阿蘇シンポジウム～生命科学のフロントランナー
- Place of Presentation
  阿蘇リゾートグランヴィリオホテル(熊本)
- Year and Date
  2009-07-31
- Data Source
  KAKENHI-PROJECT-20580313
[Presentation] グリア細胞株由来神経栄養因子GDNF発現系の構築2009
- Author(s)
  垣内一恵、久保田浩司
- Organizer
  北里大学獣医学部ハイテクリサーチセンタープロジェクト研究中間報告会
- Place of Presentation
  北里大学獣医学部(十和田)
- Year and Date
  2009-07-25
- Data Source
  KAKENHI-PROJECT-20580313
[Presentation] 精原幹細胞の自己複製と分化の制御2009
- Author(s)
  久保田浩司
- Organizer
  第33回阿蘇シンポジウム
- Place of Presentation
  熊本(阿蘇)
- Year and Date
  2009-07-31
- Data Source
  KAKENHI-PROJECT-20580313
[Presentation] 精原幹細胞研究の展望2008
- Author(s)
  久保田浩司
- Organizer
  日本実験動物科学技術2008(第55回日本実験動物学会総会、第42回日本実験動物技術者協会総会)
- Place of Presentation
  仙台国際センター(仙台)
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-20580313
[Presentation] 精原幹細胞研究の展望2008
- Author(s)
  久保田浩司
- Organizer
  日本実験動物利・学技術2008(第55回日本実験動物学会総会、第42回日本実験動物技術者協会総会)
- Place of Presentation
  仙台
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-20580313
[Presentation] 動物の精原幹細胞工学2008
- Author(s)
  久保田浩司
- Organizer
  第22回動物生殖工学研究会
- Place of Presentation
  北里大学(東京)
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-20580313
[Presentation] 哺乳動物精原幹細胞の共通性と多様性
- Author(s)
  久保田浩司
- Organizer
  京都大学霊長類研究所研究会「霊長類への展開に向けた幹細胞・生殖細胞・エピゲノム研究」
- Place of Presentation
  愛知県　京都大学霊長類研究所
- Year and Date
  2014-08-26 – 2014-08-27
- Invited
- Data Source
  KAKENHI-PROJECT-25660255
[Presentation] 精巣における細胞表面DDX4陽性細胞は生殖幹細胞か？
- Author(s)
  米澤(垣内) 一恵, 久保田浩司
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県　パシフィコ横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25660255

1. MINATO Nagahiro (40137716)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. HATTORI Masakazu (40211479)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KAKIUCHI Kazue (90509184)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
4. IWAI Kazuhiro (60252459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 高岸聖彦 (20216633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MARUTA Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUBOTA Hiroshi 久保田 浩司

久保田 浩司 クボタ ヒロシ

Research Projects

Research Products

Co-Researchers

機能的スクリーニングによる種特異的精子形成誘導因子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of spermatogonial stem cell xenotransplantation method using transgenic nude mice

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation of induced spermatogonial stem cells by direct reprogrammingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of regulatory molecules governing self-renewal versus differentiation of spermatogonial stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Unraveling the molecular mechanisms of spermatogenesis using differentiation-deficient spermatogonial stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MHC非拘束性T細胞の抗原レセプターと認識抗原の研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Nuclear small G protein system involved in cell cycle.

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Molecular mechanisms for cell cycle control in the immune system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

造血組織に局在する新しいT細胞亜群の認識レパートリーの研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Cell-Surface DEAD-Box Polypeptide 4-Immunoreactive Cells and Gonocytes Are Two Distinct Populations in Postnatal Porcine Testes2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell-Surface DEAD-Box Polypeptide 4-Immunoreactive Cells and Gonocytes Are Two Distinct Populations in Postnatal Porcine Testes2014

Author(s)

Journal Title

Data Source

[Journal Article] Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties2011

Author(s)

Journal Title

Data Source

[Journal Article] Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties2010

Author(s)

Journal Title

Data Source

[Journal Article] In vivo and in vitro aging is detrimental to mouse spermatogonial stem cell function.2010

Author(s)

Journal Title

Data Source

[Journal Article] Involvement of a membrane skeletal protein, 4.1G, for Sertoli/germ cell interaction.2010

Author(s)

Journal Title

KUBOTA Hiroshi 久保田浩司

久保田浩司クボタヒロシ