Hara Eiji 原英二

… Alternative Names

HARA Eiji 原英二

原英二ハラエイジ

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Researcher Number	80263268
Other IDs	https://orcid.org/0000-0001-7821-3960
External Links
Affiliation (Current)	2025: 大阪大学, 微生物病研究所, 教授
Affiliation (based on the past Project Information) *help	2019 – 2025: 大阪大学, 微生物病研究所, 教授 2015 – 2016: 大阪大学, 微生物病研究所, 教授 2014: 公益財団法人がん研究会, がん研究所, 部長 2012 – 2014: 公益財団法人がん研究会, がん研究所がん生物部, 部長 2011: 公益財団法人がん研究会, がん研究所・がん生物部, 部長 … More 2011: 公益財団法人がん研究会, がん研究所・がん生物部, 部長 2009 – 2010: Japanese Foundation For Cancer Research, 癌研究所がん生物部, 部長 2008 – 2010: Japanese Foundation For Cancer Research, 癌研究所がん生物部, 部長 2008: Japanese Foundation For Cancer Research, がん生物部, 部長 2004 – 2007: 徳島大学, ゲノム機能研究センター, 教授 1994: 大阪大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Pathological medical chemistry / Tumor biology / Broad Section I / Medium-sized Section 50:Oncology and related fields / Cell biology / Tumor biology / Biological Sciences Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Dermatology / Structural biochemistry / Biological Sciences
Keywords	Principal Investigator 癌 / シグナル伝達 / 細胞老化 / 発癌 / 発がん / 遺伝子 / 発現制御 / 老化 / 癌抑制 / 細胞周期 … More / ROS / ゲノム / イメージング / p53 / PKCδ / pRB / p16 / 腸内細菌 / ストレス / 加齢 / p16^<INK4a> / Tumor suppression / Cytokinesis / Cellular Senescence / 不死化 / PI3キナーゼ / 細胞質分裂 / 微生物 / 肥満 / 国際情報交換 / アポトーシス / 活性酸素種 / 液性因子 / がん微小環境 / インビボ・イメージング / 転写調節 / ルシフェラーゼ / p14^<ARF> / 可視化 / P16^<INK4a> / 発癌ストレス / 染色体 / ARF遺伝子座 / INK4A / CDK / Fbxo7 / 増殖刺激 / CDK6 / サイクリンD1 / CRM1 / LMP1 / EBウイルス / RB … More Except Principal Investigator c-Met / HGF / インジュリン / c-met / 血管新生 / 器官再生 / 次世代シーケンス / リスク診断 / NGS / 大腸フローラ / 口腔細菌叢 / 大腸マイクロバイオーム / 大腸癌 / 口腔 / 便 / 唾液 / 口腔常在菌 / 真菌叢 / 細菌叢 / 大腸がん / Solobacterium moorei / Peptostreptococcus / 歯周病菌 / 口腔マイクロバイオーム / 16S rRNA / 次世代シーケンサー / Fusobacterium nucleatum / マイクロバイオーム / skin cancer / bioluminescence in vivo imaging / p16^<INK4a> gene / BAC / 可視化 / p16^<Ink4a>遺伝子 / 皮膚癌 / イメージング / p16^<INK4a>遺伝子 / growth factor / injurin / organ regeneration / organogenesis / MET / 腎再生 / 肝再生 / hepatocyte growth factor / FGF / PDGF / カルシノーマ / IL-1 / 増殖因子 / 器官形成 / ゲノム医学 / リンパ管新生 / 転移 / がん浸潤 / がん微小環境 / ゲノム科学 / 生体イメージング / 生体材料 / シグナル伝達 / 微小環境 / c-sea / 肺線維症 / Ron / HLP / 上皮-間葉相互作用 / Met / Fas / 浸潤・転移 / 形態形成 / Sky / 劇症肝炎 / 遺伝子治療 / 心筋梗塞 / 脂肪肝 / 腫瘍血管新生 / LIMキナーゼ / HGFアンタゴニスト / 浸潤・転移阻止 / 慢性腎不全 / 肝硬変 Less

加齢性発癌の制御に向けた細胞老化の発癌促進作用の解明Principal Investigator
- Principal Investigator
  
  原英二
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  The University of Osaka
Studies on the role of gut bacteria and cellular senescence in age-related carcinogenesis and its controlPrincipal Investigator
- Principal Investigator
  
  原英二
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Osaka University
Creation of colorectal cancer risk diagnosis and prevention concept by oral and colonic microbiome analysis
- Principal Investigator
  
  Goto Yuichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kagoshima University
Study of obesity-associated carcinogenesis and its application to cancer preventionPrincipal Investigator
- Principal Investigator
  
  Hara Eiji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor biology
- Research Institution
  Osaka University
  Japanese Foundation for Cancer Research
Understanding of the anti-apoptotic mechanisms in senescent cellsPrincipal Investigator
- Principal Investigator
  
  HARA Eiji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation for Cancer Research
Roles and mechanisms of cellular senescence in cancer microenvironmentPrincipal Investigator
- Principal Investigator
  
  HARA Eiji
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation for Cancer Research
Study on senescence-associated tumor promotionPrincipal Investigator
- Principal Investigator
  
  HARA Eiji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation for Cancer Research
細胞老化の不可逆性を規定する分子機構の解明Principal Investigator
- Principal Investigator
  
  原英二
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
Integrative Research on Cancer Microenvironment Network
- Principal Investigator
  
  MIYAZONO Kohei
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
細胞老化の発癌制御に関する2面性とその調節に関する研究Principal Investigator
- Principal Investigator
  
  原英二
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Japanese Foundation For Cancer Research
Visualizing the dynamics of senescence response in vivoPrincipal Investigator
- Principal Investigator
  
  HARA Eiji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Japanese Foundation For Cancer Research
分子イメージングを用いた新しい発癌リスク評価システムの開発Principal Investigator
- Principal Investigator
  
  原英二
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Japanese Foundation For Cancer Research
Studies on the irreversibility of cellular senescence and its role in vivoPrincipal Investigator
- Principal Investigator
  
  HARA Eiji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  The University of Tokushima
Regulation of INK4a/ARF gene locus and its role in cellular senescencePrincipal Investigator
- Principal Investigator
  
  HARA Eiji
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
  The University of Tokushima
EBウイルスLMP1癌蛋白によるp16^<INK4a>/RB経路阻害機構の解明Principal Investigator
- Principal Investigator
  
  原英二
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
増殖刺激によるサイクリンD1キナーゼ活性化機構の解明Principal Investigator
- Principal Investigator
  
  原英二
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Induction of p16^<INK4a> gene expression by oncogenic stress is involved in the tumor suppression mechanism of skin cancer
- Principal Investigator
  
  OHTANI Naoko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  University of Tokushima
HGFならびにLIMキナーゼによる高次細胞機能の調節とがん特性の研究
- Principal Investigator
  
  NAKAMURA Toshikazu
- Project Period (FY)
  1994 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
Molecular mechanisms of organ regeneration and homeoslasis by injurin/HGF system.
- Principal Investigator
  
  NAKAMURA Toshikazu
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University

[Book] 細胞周期アッセイ法がん分子標的治療研究マニュアル2009
- Author(s)
  高橋暁子、原英二
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-17013064
[Book] がん分子標的治療研究マニュアル(鶴尾隆/曽根三郎編)(細胞周期アッセイ法)2009
- Author(s)
  高橋暁子、原英二
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-20390094
[Journal Article] Crosstalk between gut microbiota and cellular senescence: a vicious cycle leading to aging gut2024
- Author(s)
  Kawamoto Shimpei、Hara Eiji
- Journal Title
  
  Trends in Cell Biology
  
  Volume: 13 Issue: 8 Pages: 626-635
- DOI
  10.1016/j.tcb.2023.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H00457
[Journal Article] Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype2023
- Author(s)
  Matsudaira Tatsuyuki、Nakano Sosuke、Konishi Yusuke、Kawamoto Shimpei、Uemura Ken、Kondo Tamae、Sakurai Koki、Ozawa Takaaki、Hikida Takatoshi、Komine Okiru、Yamanaka Koji、Fujita Yuki、Yamashita Toshihide、Matsumoto Tomonori、Hara Eiji
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 665-665
- DOI
  10.1038/s42003-023-05027-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06481, KAKENHI-PROJECT-21K18557, KAKENHI-PROJECT-22KJ2043, KAKENHI-PROJECT-22H00457, KAKENHI-PROJECT-23K22376, KAKENHI-PROJECT-23K24205
[Journal Article] Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota2023
- Author(s)
  Kawamoto Shimpei、Uemura Ken、Hori Nozomi、Takayasu Lena、Konishi Yusuke、Katoh Kazutaka、Matsumoto Tomonori、Suzuki Masae、Sakai Yusuke、Matsudaira Tatsuyuki、Adachi Takahiro、Ohtani Naoko、Standley Daron M.、Suda Wataru、Fukuda Shinji、Hara Eiji
- Journal Title
  
  Nature Cell Biology
  
  Volume: 25 Issue: 6 Pages: 865-876
- DOI
  10.1038/s41556-023-01145-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06481, KAKENHI-PROJECT-22H00457, KAKENHI-PROJECT-21H03369, KAKENHI-PROJECT-23K24798
[Journal Article] Are intratumoral microbiota involved in the progression of intraductal papillary mucinous neoplasms of the pancreas?2023
- Author(s)
  Hozaka Yuto、Oi Hideyuki、Satake Souichi、Uchino Yoshinori、Goto Yuichi、Idichi Tetsuya、Tanoue Kiyonori、Yamasaki Yoichi、Kawasaki Yota、Mataki Yuko、Kurahara Hiroshi、Nakajo Akihiro、Higashi Michiyo、Tanimoto Akihide、Sugiura Tsuyoshi、Ohtsuka Takao
- Journal Title
  
  Surgery
  
  Volume: 173 Issue: 2 Pages: 503-510
- DOI
  10.1016/j.surg.2022.10.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10224, KAKENHI-PROJECT-22K19567, KAKENHI-PROJECT-22K16514, KAKENHI-PROJECT-20H03753, KAKENHI-PROJECT-19K10361, KAKENHI-PROJECT-21K16453, KAKENHI-PROJECT-21K06889
[Journal Article] RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells2022
- Author(s)
  Sugawara S, Okada R, Loo TM, Tanaka H, Miyata K, Chiba M, Kawasaki H, Katoh K, Kaji S, Maezawa Y, Yokote K, Nakayama M, Oshima M, Nagao K, Obuse C, Nagayama S, Takubo K, Nakanishi A, Kanemaki MT, Hara E, Takahashi A.
- Journal Title
  
  Commun Biol
  
  Volume: 5 Issue: 1 Pages: 1420-1420
- DOI
  10.1038/s42003-022-04369-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22H00457, KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-22KJ3105, KAKENHI-PROJECT-21K19419, KAKENHI-PROJECT-20K16344, KAKENHI-PROJECT-19H03156, KAKENHI-PLANNED-18H05532, KAKENHI-PLANNED-17H06426, KAKENHI-PUBLICLY-22H05599, KAKENHI-PROJECT-23K23810
[Journal Article] Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common?A Metagenomic Comparison with Healthy Subjects2021
- Author(s)
  Uchino Yoshinori、Goto Yuichi、Konishi Yusuke、Tanabe Kan、Toda Hiroko、Wada Masumi、Kita Yoshiaki、Beppu Mahiro、Mori Shinichiro、Hijioka Hiroshi、Otsuka Takao、Natsugoe Shoji、Hara Eiji、Sugiura Tsuyoshi
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 13 Pages: 3332-3332
- DOI
  10.3390/cancers13133332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10361, KAKENHI-PROJECT-21K08783
[Journal Article] Oral ulcers suspected to be caused by improper administration of bisphosphonate2019
- Author(s)
  新田哲也, 坂元亮一, 平原成浩, 松村吉晃, 中村康大, 後藤雄一
- Journal Title
  
  Japanese Journal of Oral and Maxillofacial Surgery
  
  Volume: 65 Issue: 9 Pages: 599-604
- DOI
  10.5794/jjoms.65.599
- NAID
  130007748571
- ISSN
  0021-5163, 2186-1579
- Year and Date
  2019-09-20
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10361
[Journal Article] Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity.2017
- Author(s)
  Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.
- Journal Title
  
  Cancer Discov
  
  Volume: in press Issue: 5 Pages: 522-538
- DOI
  10.1158/2159-8290.cd-16-0932
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05898, KAKENHI-PLANNED-15H05905, KAKENHI-PROJECT-26250028, KAKENHI-PROJECT-14J06998, KAKENHI-PROJECT-15K12709, KAKENHI-PROJECT-15K19032, KAKENHI-PROJECT-26670030, KAKENHI-PROJECT-15K19031, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-15H04648, KAKENHI-PROJECT-17H03990, KAKENHI-PROJECT-26460565, KAKENHI-PROJECT-16H04699
[Journal Article] Exosomes maintain cellular homeostasis by excreting harmful DNA from cells2017
- Author(s)
  Takahashi, A., Okada, R., Nagao, K., Kawamata, Y., Hanyu, A., Yoshimoto, S., Takasugi, M., Watanabe, S., Kanemaki, M.T., Obuse, C. & Hara, E.
- Journal Title
  
  Nature Communications
  
  Volume: - Issue: 1 Pages: 15287-15287
- DOI
  10.1038/ncomms15287
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26250028, KAKENHI-PROJECT-17K19618, KAKENHI-PUBLICLY-17H05628, KAKENHI-PLANNED-17H06426, KAKENHI-PLANNED-25116004, KAKENHI-PROJECT-16H04700, KAKENHI-PROJECT-16H04739, KAKENHI-PROJECT-15K06942, KAKENHI-PROJECT-16K15095
[Journal Article] The impact of SASP and its potential as a therapeutic target for senescence-associated diseases.2017
- Author(s)
  Watabnabe, S., Kawamoto, S., Ohtani, N., & Hara, E.
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 4 Pages: 563-569
- DOI
  10.1111/cas.13184
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26250028, KAKENHI-PROJECT-26430116, KAKENHI-PROJECT-16H04699
[Journal Article] Mechanisms of action of bone morphogenetic proteins in cancer2016
- Author(s)
  Davis H, Raja E, Miyazono K, Tsubakihara Y, Moustakas A.
- Journal Title
  
  Cytokine Growth Factor Rev.
  
  Volume: 27 Pages: 81-92
- DOI
  10.1016/j.cytogfr.2015.11.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-22112001, KAKENHI-PROJECT-24390070, KAKENHI-PROJECT-15H05774
[Journal Article] In vivo imaging models of bone and brain metastases and pleural carcinomatosis with a novel human EML4-ALK lung cancer cell line.2015
- Author(s)
  Nanjo S, Yano S, et al.
- Journal Title
  
  Cancer Sci
  
  Volume: 106 Issue: 3 Pages: 244-52
- DOI
  10.1111/cas.12600
- NAID
  120005830611
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22112010, KAKENHI-PLANNED-23112101, KAKENHI-PROJECT-24390209, KAKENHI-PROJECT-24650625, KAKENHI-PROJECT-24659403, KAKENHI-PROJECT-25860640, KAKENHI-PROJECT-26250028, KAKENHI-PROJECT-26293322, KAKENHI-PROJECT-25462190, KAKENHI-PROJECT-25462202
[Journal Article] Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice2015
- Author(s)
  Seidai Sato, Yuka Kawamata, Akiko Takahashi, Yoshinori Imai, Aki Hanyu, Atsushi Okuma, Masaki Takasugi, Kimi Yamakoshi, Hiroyuki Sorimachi, Hiroaki Kanda, Yuichi Ishikawa, Saburo Sone, Yasuhiko Nishioka, Naoko Ohtani and Eiji Hara
- Journal Title
  
  Nature communications
  
  Volume: 6 Issue: 1 Pages: 7035-7035
- DOI
  10.1038/ncomms8035
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J06532, KAKENHI-PROJECT-14J10280, KAKENHI-PROJECT-14J10710, KAKENHI-PROJECT-24650625, KAKENHI-PROJECT-26250028, KAKENHI-PROJECT-26670418, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15K19421, KAKENHI-PROJECT-25290046
[Journal Article] Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice.2015
- Author(s)
  Sato, S., Kawamata, Y., Takahashi, A., Imai, Y., Hanyu, A., Okuma, A., Takasugi, M., Yamakoshi, K.,　Sorimachi, H., Kanda, H., Ishikawa, Y., Sone, S., Nishioka, Y., Ohtani, N., Hara, E.
- Journal Title
  
  Nature Communications
  
  Volume: 6:7035 Pages: 1-10
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23112101
[Journal Article] Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence.2015
- Author(s)
  Brookes S, Gagrica S, Sanij E, Rowe J, Gregory FJ, Hara E, and *Peters G.
- Journal Title
  
  Cell Cycle
  
  Volume: 14 Issue: 8 Pages: 1164-1173
- DOI
  10.1080/15384101.2015.1010866
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23112101, KAKENHI-PROJECT-24650625, KAKENHI-PROJECT-26250028
[Journal Article] Dysregulation of the Bmi-1/p16Ink4a pathway provokes an aging-associated decline of submandibular gland function.2015
- Author(s)
  Yamakoshi K, Katano S, Iida M, Kimura H, Okuma A, Ikemoto-Uezumi M, Ohtani N, Hara E, Maruyama M.
- Journal Title
  
  Aging Cell
  
  Volume: - Issue: 4 Pages: 1-9
- DOI
  10.1111/acel.12337
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J10280, KAKENHI-PLANNED-23112101, KAKENHI-PROJECT-24650625, KAKENHI-PROJECT-26250028, KAKENHI-PROJECT-15K12709, KAKENHI-PROJECT-25861349
[Journal Article] Crosstalk between the RB-pathway and AKT signalling forms a Quiescence-Senescence switch.2014
- Author(s)
  Imai, Y., Takahashi, A., Hanyuu, A., Hori, S., Sato, S., Naka, K., Hirao, A., Ohtani, N., Hara, E.
- Journal Title
  
  Cell Reports
  
  Volume: 7 Issue: 1 Pages: 194-207
- DOI
  10.1016/j.celrep.2014.03.006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23112101, KAKENHI-PROJECT-23300343, KAKENHI-PROJECT-23300352, KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24650625, KAKENHI-PUBLICLY-25130705, KAKENHI-PROJECT-25290046, KAKENHI-PROJECT-26250028
[Journal Article] Crosstalk between the Rb pathway and AKT signaling forms a quiescence-senescence switch2014
- Author(s)
  Imai, Y., Takahashi, A., Hanyu, A., Sato, S., Naka, K., Hirao, A., Ohtani, N., Hara, E
- Journal Title
  
  Cell Reports
  
  Volume: 7 Pages: 194-1207
- Data Source
  KAKENHI-PROJECT-23300352
[Journal Article] Obesity and cancer : gut microbial connection2014
- Author(s)
  Ohtani, N., Yoshimoto, S., Hara, E
- Journal Title
  
  Cancer Research
  
  Volume: 74 Pages: 1885-1889
- Data Source
  KAKENHI-PROJECT-23300352
[Journal Article] Necessary and sufficient role for a mitosis skip in senescence induction.2014
- Author(s)
  Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, Takahashi S, Nakanishi M.
- Journal Title
  
  Mol.Cell
  
  Volume: 55 Issue: 1 Pages: 73-84
- DOI
  10.1016/j.molcel.2014.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22118003, KAKENHI-PLANNED-23112101, KAKENHI-PROJECT-24590369, KAKENHI-PROJECT-24650625, KAKENHI-PROJECT-26250027, KAKENHI-PROJECT-26250028, KAKENHI-PROJECT-26860195
[Journal Article] An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.2014
- Author(s)
  Demaria, M., Ohtani, N., Youssef, S.A., Rodier, F., Toussaint, W., Mitchell, J.R., Laberge, R.M., Vijg, J., Van Steeg, H., Dollé, M.E.T., Hoeijmakers, J.H.J., de Bruin, A., Hara, E.., Campisi, J.
- Journal Title
  
  Developmental Cell
  
  Volume: 31 Issue: 6 Pages: 722-733
- DOI
  10.1016/j.devcel.2014.11.012
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23112101, KAKENHI-PROJECT-24650625, KAKENHI-PROJECT-26250028
[Journal Article] Obesity and Cancer: a gut microbial connection2014
- Author(s)
  Ohtani, N.
- Journal Title
  
  Cancer Research
  
  Volume: 74 Issue: 7 Pages: 1885-11889
- DOI
  10.1158/0008-5472.can-13-3501
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23112101, KAKENHI-PROJECT-24650625
[Journal Article] Expression of Aggrus/podoplanin in bladder cancer and its role in pulmonary metastasis2014
- Author(s)
  Takagi S, Oh-hara T, Sato S, Gong B, Takami M, Fujita N.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 134 Issue: 11 Pages: 2605-2614
- DOI
  10.1002/ijc.28602
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112008, KAKENHI-PROJECT-25830125
[Journal Article] Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome2013
- Author(s)
  Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., Ishikawa, Y., Hara, E., Ohtani, N
- Journal Title
  
  Nature
  
  Volume: 499 Pages: 97-101
- Data Source
  KAKENHI-PROJECT-23300352
[Journal Article] Roles and mechanisms of cellular senescence in regulation of tissue homeostasis2013
- Author(s)
  Ohtani, N., Hara, E
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Pages: 525-530
- Data Source
  KAKENHI-PROJECT-23300352
[Journal Article] DNA damage signaling triggers degradation of histone methyltransferases through APC/C^<Cdh1> in senescent cells2012
- Author(s)
  Takahashi, A., Imai, Y., Yamakoshi, K., Kuninaka, S., Ohtani, N., Yoshimoto, S., Hori, S., Tachibana, M., Anderton, E., Takeuchi, T., Shinkai, Y., Peters, G., Saya, H. and Hara E
- Journal Title
  
  Mol. Cell
  
  Volume: 45 Pages: 123-131
- Data Source
  KAKENHI-PROJECT-23300352
[Journal Article] DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells2012
- Author(s)
  Akiko Takahashi
- Journal Title
  
  Molecular Cell
  
  Volume: 45 Issue: 1 Pages: 123-131
- DOI
  10.1016/j.molcel.2011.10.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J10697, KAKENHI-PLANNED-19057011, KAKENHI-PUBLICLY-22019043, KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-23112101, KAKENHI-PROJECT-23300352, KAKENHI-PROJECT-24590360, KAKENHI-PROJECT-24657155
[Journal Article] Protein kinase A determines timing of early differentiation through epigenetic regulation with G9a2012
- Author(s)
  Yamamizu, K., Fujihara, M., Tachibana, M., Katayama, S., Takahashi, A., Hara, E., Imai, H., Shinkai, Y., and Yamashita, J. K
- Journal Title
  
  Cell Stem Cell
  
  Volume: 10 Pages: 759-770
- Data Source
  KAKENHI-PROJECT-23300352
[Journal Article] Cellular senescence : a double-edged sword in the fight against cancer2012
- Author(s)
  Ohtani, N., Takahashi, A. Mann, D.J. and Hara, E
- Journal Title
  
  Exp. Dermatol
  
  Volume: 21
- Data Source
  KAKENHI-PROJECT-23300352
[Journal Article] Development of mice without Cip/Kip CDK inhibitors2012
- Author(s)
  Tateishi, Y., Matsumoto. A., Kanie, T., Hara, E., Nakayama, K., Nakayama, K.I
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 427 Pages: 285-292
- Data Source
  KAKENHI-PROJECT-23300352
[Journal Article] Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interferes with epidermal growth factor receptor (EGFR) signaling.2011
- Author(s)
  Kitajima S., Miki T., Takegami Y., Kido Y., Noda M., Hara E., Shamma A., Takahashi C.
- Journal Title
  
  Oncogene 30
  
  Pages: 737-750
- Data Source
  KAKENHI-PROJECT-20390094
[Journal Article] E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability2011
- Author(s)
  Fukuyo, Y., Takahashi, A., Hara, E., Horikoshi, N., Pandita, T. K., Nakajima, T
- Journal Title
  
  Int J Oral Sci
  
  Volume: 3 Pages: 200-208
- Data Source
  KAKENHI-PROJECT-23300352
[Journal Article] Enhancement of ectopic osteoid formation following the dual release of bone morphogenetic protein-2 and Wnt1 inducible signaling pathway protein 1 from gelatin sponges2011
- Author(s)
  Kohara, H., Tabata, Y.
- Journal Title
  
  Biomaterials
  
  Volume: 32 Issue: 24 Pages: 5726-5732
- DOI
  10.1016/j.biomaterials.2011.04.035
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112002
[Journal Article] TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition.2011
- Author(s)
  Shirakihara T, Miyazono K, et al.
- Journal Title
  
  EMBO Journal
  
  Volume: 30 Pages: 783-795
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22112001
[Journal Article] Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator seil.2010
- Author(s)
  Fernandez-Marcos P.J., Pantoja C., Gonzalez-Rodriguez A., Martin N., Flores J.M., Valverde A.M., Hara E., Serrano M.
- Journal Title
  
  PLoS One. 18
- Data Source
  KAKENHI-PROJECT-20390094
[Journal Article] Intrinsic cooperation between p16^<INK4a> and p21^<Waf1/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010
- Author(s)
  Takeuchi S., Takahashi A., Motoi N., Yoshimoto S., Tajima T., Yamakoshi K., Hirao A., Yanagi S., Fukami K., Ishikawa Y., Sone S., Hara E., Ohtani N.
- Journal Title
  
  Cancer Res. 70
  
  Pages: 9381-9390
- Data Source
  KAKENHI-PROJECT-20390094
[Journal Article] Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation2009
- Author(s)
  Inomata, K., Aoto, T., Binh, N.T., Okamoto, N., Tanimura, S., Wakayama, T., Iseki, S., Hara, E., Masunaga, T., Shimizu, H., Nishimura, E.K.
- Journal Title
  
  Cell 137
  
  Pages: 1088-1099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013064
[Journal Article] Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.2009
- Author(s)
  Inomata K., Aoto T., Binh N.T., Okamoto N., Tanimura S., Wakayama T., Iseki S., Hara E., Masunaga T., Shimizu H., Nishimura E.K.
- Journal Title
  
  Cell 137
  
  Pages: 1088-1099
- Data Source
  KAKENHI-PROJECT-20390094
[Journal Article] Real-time in vivo imaging of p16Ink4a reveals cross-talk with p52009
- Author(s)
  Yamakoshi, K., Takahashi, A., Hirota, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, D.J., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto, M., Ohtani, N., Hara, E.
- Journal Title
  
  J. Cell Biol. 186
  
  Pages: 393-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013064
[Journal Article] Real-time in vivo imaging of p16^<Ink4a> reveals cross-talk with p53.2009
- Author(s)
  Yamakoshi K., Takahashi A., Hirota F., Nakayama R., Ishimaru N., Kubo Y., Mann D.J., Ohmura M., Hirao A., Saya H., Arase S., Hayashi Y., Nakao K., Matsumoto M., Ohtani N., Hara E.
- Journal Title
  
  J. Cell Biol. 186
  
  Pages: 393-407
- Data Source
  KAKENHI-PROJECT-20390094
[Journal Article] Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals2007
- Author(s)
  Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., Mann, D.J., Saya, H., Hayashi, Y., Arase, S., Matsumoto, M., Nakao, K., Hara, E.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 104
  
  Pages: 15034-15039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013064
[Journal Article] Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence2006
- Author(s)
  Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., Saya, H., Hara, E.
- Journal Title
  
  Nature Cell Biol. 8
  
  Pages: 1291-1297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013064
[Journal Article] Epigenetic abnormalities in cutaneous squamous cell carcinomas : Frequent inactivation of the RBI/p16 and p53 pathways.2006
- Author(s)
  Murao, K., Kubo, Y., Ohtani, N., Hara, E., Arase S
- Journal Title
  
  British Journal of Dermatology 155
  
  Pages: 999-1005
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] and Arase S Epigenetic abnormalities in cutaneous squamous cell carcinomas : Frequent inactivation of the RB1/p16 and p53 pathways.2006
- Author(s)
  Murao, K., Kubo, Y., Ohtani, N., Hara, E.
- Journal Title
  
  British Journal of Dermatology 155
  
  Pages: 999-1005
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence2006
- Author(s)
  Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., Saya, H., Hara, E.
- Journal Title
  
  Nature Cell Biology 8
  
  Pages: 1291-1297
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence.2006
- Author(s)
  Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., Saya, H., Hara, E.
- Journal Title
  
  Nature Cell Biology 8
  
  Pages: 1291-1297
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence.2006
- Author(s)
  Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H., Nakayama, K., Nakayama, K.I., Ide, T., H., Saya, H., Hara, E.
- Journal Title
  
  Nature Cell Biology 8
  
  Pages: 1291-1297
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Epigenetic abnormalities in cutaneous squamous cell carcinomas : Frequent inactivation of the RB1/p16 and p53 pathways.2006
- Author(s)
  Murao, K., Kubo, Y., Ohtani, N., Hara, E., Arase S
- Journal Title
  
  British Journal of Dermatology 155
  
  Pages: 999-1005
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53.2005
- Author(s)
  Maehara K, Yamakoshi K, Ohtani N, Kubo Y, Takahashi A, Arase S, Jones N, Hara E
- Journal Title
  
  Journal of Cell Biology 168
  
  Pages: 552-560
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390318
[Journal Article] Transforming activity of Fbxo7 is mediated specifically through regulation of cyclinD/cdk62005
- Author(s)
  Laman, H., Funes, J., Ye, H., Henderson, S., Galinanes-Garcia, L., Hara, E., Knowles, P., McDonald, N., Boshoff, C.
- Journal Title
  
  EMBO J. 24
  
  Pages: 3104-3116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013064
[Journal Article] Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p532005
- Author(s)
  Kayoko Maehara
- Journal Title
  
  The Journal of Cell Biology 168
  
  Pages: 553-560
- Data Source
  KAKENHI-PROJECT-16026231
[Journal Article] Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p532005
- Author(s)
  Kayoko Maehara
- Journal Title
  
  The Journal of Cell Biology 168
  
  Pages: 553-560
- Data Source
  KAKENHI-PROJECT-17013064
[Journal Article] Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p532005
- Author(s)
  Kayoko Maehara
- Journal Title
  
  The Journal of Cell Biology 168
  
  Pages: 553-560
- Data Source
  KAKENHI-PROJECT-16021242
[Journal Article] Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p532005
- Author(s)
  Maehara, K., Yamakoshi, K., Ohtani, N., Kubo, Y., Takahashi, A., Arase, S., Jones, N., Hara, E.
- Journal Title
  
  J. Cell Biol. 167
  
  Pages: 553-560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013064
[Presentation] 細胞老化のメカニズムと役割ー細胞老化研究の光と影ー2023
- Author(s)
  原英二
- Organizer
  CVMW2023 KOBE
- Invited
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] Toward the identification and control of the causes of cellular senescence induction in vivo2023
- Author(s)
  Eiji Hara
- Organizer
  Seno-Therapeutics Summit
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] Cellular senescence and cancer: relevance to microorganisms2023
- Author(s)
  原英二
- Organizer
  日本生理学会
- Invited
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] Role of cellular senescence in aging and cancer: Relationship with microorganisms2023
- Author(s)
  Eiji Hara
- Organizer
  8th International Cell Senescence Association Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] Cellular senescence : relevance to microorganisms2023
- Author(s)
  Eiji Hara
- Organizer
  Wiggers-Bernard Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] Induction of cellular senescence by viral infection and its effects on the host2023
- Author(s)
  Eiji Hara
- Organizer
  日本分子生物学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] The role of cellular senescence in aging and cancer: Molecular analysis of host-microbial relationships2023
- Author(s)
  Eiji Hara
- Organizer
  IAGG/Asia Oceania Regional Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] Role of cellular senescence in aging and cancer: Relationship with microorganisms2023
- Author(s)
  Eiji Hara
- Organizer
  Australian Cell Cycle, DNA Repair and Telomere Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] The Role of Cellular Senescence in Cancer and Aging: Relevance to Microorganisms2022
- Author(s)
  Eiji Hara
- Organizer
  EMBO Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] 細胞老化による発癌制御：微生物の関与について2022
- Author(s)
  原英二
- Organizer
  日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] Cellular Snescence and Cancer: A Gut Microbial Connection2022
- Author(s)
  Eiji Hara
- Organizer
  14th International Congress of Cell Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] Cellular senescence and cancer : a gut microbial connection2022
- Author(s)
  原英二
- Organizer
  日本免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] Cellular senescence and cancer: relevance to microorganisms2022
- Author(s)
  原英二
- Organizer
  日本癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-22H00457
[Presentation] Involvement of oral flora in the colonic flora of colorecral cancer2020
- Author(s)
  Uchino Yoshinori, Goto Yuichi, Kita Yoshiaki, Hara Eiji, Sugiura Tsuyoshi
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-19K10361
[Presentation] Obesity and cancer : a gut microbial connection2016
- Author(s)
  Eiji Hara
- Organizer
  日本癌学会
- Place of Presentation
  横浜市
- Year and Date
  2016-10-06
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] Obesity, the gut microbiome and liver cancer2016
- Author(s)
  Eiji Hara
- Organizer
  EASL The International Liver Congress
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2016-04-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] Cellular senescence and liver cancer : a gut microbial connection2016
- Author(s)
  Eiji Hara
- Organizer
  FASEB Conference, Liver Biology
- Place of Presentation
  West palm beach, FL, USA
- Year and Date
  2016-06-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] 腸内細菌による発がん制御2016
- Author(s)
  原　英二
- Organizer
  日本臨床栄養学会
- Place of Presentation
  大阪市
- Year and Date
  2016-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] 細胞老化の発がん制御における役割2015
- Author(s)
  原　英二
- Organizer
  ヒューマンサイエンス総合研究セミナー
- Place of Presentation
  東京
- Year and Date
  2015-01-13
- Invited
- Data Source
  KAKENHI-PROJECT-24650625
[Presentation] Obesity and cellular senescence: a gut microbial connection2015
- Author(s)
  Eiji Hara
- Organizer
  International Cell Senescence Association Conference
- Place of Presentation
  Santiago de Compostela, Spain
- Year and Date
  2015-07-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] 細胞老化の発癌制御における役割2015
- Author(s)
  原英二
- Organizer
  ヒューマンサイエンス総合研究セミナー
- Place of Presentation
  東京
- Year and Date
  2015-01-13
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Obesity and Cellular Senescence: a gut microbial connection2015
- Author(s)
  Eiji Hara
- Organizer
  EMBO Workshop Developmental Circuits in Aging
- Place of Presentation
  Crete, Greece
- Year and Date
  2015-05-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] 肥満と肝がん：腸内細菌の関与について2015
- Author(s)
  原英二
- Organizer
  泌尿器科分子細胞研究会
- Place of Presentation
  東京
- Year and Date
  2015-02-27
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretom.2014
- Author(s)
  Eiji Hara
- Organizer
  US-Japan Joint Meeting on Biomarkers for Early Cancer Detection.
- Place of Presentation
  Gaithersburg (USA)
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] 細胞老化と発がん2014
- Author(s)
  原英二
- Organizer
  日本臨床分子医学会
- Place of Presentation
  東京
- Year and Date
  2014-04-12
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretom2014
- Author(s)
  Hara, E
- Organizer
  US-Japan Joint Meeting on Biomarkers for Early Cancer Detection
- Place of Presentation
  Gaithersburg (USA)
- Data Source
  KAKENHI-PROJECT-23300352
[Presentation] 細胞老化による発がん制御2014
- Author(s)
  原　英二
- Organizer
  肺リモデリング研究会
- Place of Presentation
  東京
- Year and Date
  2014-11-08
- Invited
- Data Source
  KAKENHI-PROJECT-24650625
[Presentation] DNA damage response and cellular senescence in cancer2013
- Author(s)
  Eiji Hara
- Organizer
  9th AACR-JCA joint conference
- Place of Presentation
  Hyatt Regency Maui (米国、ハワイ）
- Year and Date
  2013-02-21
- Invited
- Data Source
  KAKENHI-ORGANIZER-22112001
[Presentation] Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome2013
- Author(s)
  Hara, E.
- Organizer
  17th International Symposium on Cell of the Hepatic Sinusoid.
- Place of Presentation
  大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-24650625
[Presentation] DNA damage response and cellular senescence in cancer and aging.2013
- Author(s)
  Eiji Hara
- Organizer
  International Conference of the Korean Society for Molecular and Cellular Biology
- Place of Presentation
  Seoul (South Korea)
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretom2013
- Author(s)
  Hara, E
- Organizer
  17th International Symposium on Cell of the Hepatic Sinusoid
- Place of Presentation
  Osaka (Japan)
- Data Source
  KAKENHI-PROJECT-23300352
[Presentation] 細胞老化のがん化と老化における役割2013
- Author(s)
  原英二
- Organizer
  日本生化学会シンポジウム
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23300352
[Presentation] DNA damage response and cellular senescence in cancer2013
- Author(s)
  Hara, E.
- Organizer
  9th AACR-JCA joint conference
- Place of Presentation
  Maui, HI, (U.S.A.)
- Year and Date
  2013-02-21
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] 細胞老化のがんと老化における役割2013
- Author(s)
  原　英二
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-23300352
[Presentation] Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome2013
- Author(s)
  Eiji Hara
- Organizer
  17th International Symposium on Cells of the Hepatic Sinusoid
- Place of Presentation
  大阪国際会議場（大阪）
- Invited
- Data Source
  KAKENHI-ORGANIZER-22112001
[Presentation] DNA damage response and cellular senescence in cancer and aging2013
- Author(s)
  Hara, E
- Organizer
  International Conference of the Korean Society for Molecular and Cellular Biology
- Place of Presentation
  Seoul, (South Korea)
- Data Source
  KAKENHI-PROJECT-23300352
[Presentation] 細胞老化のがん化と廊下における役割2013
- Author(s)
  原　英二
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Cellular senescence : a double-edged sword in the fight against cancer2012
- Author(s)
  Hara, E
- Organizer
  International Symposium on Clinical & Translational Cancer Research
- Place of Presentation
  Kaoshun (Taiwan)
- Data Source
  KAKENHI-PROJECT-23300352
[Presentation] 細胞老化とがん2012
- Author(s)
  原　英二
- Organizer
  日本女性医学会
- Place of Presentation
  山形市
- Invited
- Data Source
  KAKENHI-PROJECT-23300352
[Presentation] Cellular senescence: a double-edged sword in the fight against cancer2012
- Author(s)
  Hara, E.
- Organizer
  International Symposium on Clinical Translational Cancer Research
- Place of Presentation
  高雄市（台湾）
- Year and Date
  2012-05-17
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] The roles of cellular senescence in cancer and aging.2012
- Author(s)
  Hara, E.
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡市
- Year and Date
  2012-12-11
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] 細胞老化とがん2012
- Author(s)
  原英二
- Organizer
  日本女性医学会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-23300352
[Presentation] 細胞老化の分子メカニズムとその生体内機能2012
- Author(s)
  原　英二
- Organizer
  日本生化学会関東支部会シンポジウム
- Place of Presentation
  前橋市
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] The roles of cellular senescence in cancer and aging2012
- Author(s)
  原　英二
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡市
- Invited
- Data Source
  KAKENHI-PROJECT-23300352
[Presentation] The roles and mechanisms regulating cellular2012
- Author(s)
  Hara, E.
- Organizer
  日本癌学会
- Place of Presentation
  札幌市
- Year and Date
  2012-09-19
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Cellular senescence: a double-edged sword in the fight against cancer.2012
- Author(s)
  Hara, E.
- Organizer
  International Symposium on Clinical & Translational Cancer Research
- Place of Presentation
  高雄市（台湾）
- Invited
- Data Source
  KAKENHI-PROJECT-23300352
[Presentation] The roles of cellular senescence in cancer and aging.2012
- Author(s)
  原　英二
- Organizer
  日本分子生物学会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-24650625
[Presentation] 細胞老化の分子機構とその役割2011
- Author(s)
  原英二
- Organizer
  日本血管生物医学会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PUBLICLY-22019043
[Presentation] 細胞老化の分子機構とその役割2011
- Author(s)
  原英二
- Organizer
  日本血管生物医学会
- Place of Presentation
  東京
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-23300352
[Presentation] The roles and mechanisms regulating cellular senescence in aging and cancer2011
- Author(s)
  Eiji Hara
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-23300352
[Presentation] The roles and mechanisms regulating cellular senescence in aging and cancer2011
- Author(s)
  Eiji Hara
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] The roles and mechanisms regulating cellular senescence in aging and cancer2011
- Author(s)
  Eiji Hara
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PUBLICLY-22019043
[Presentation] 細胞老化の分子機構とその役割2011
- Author(s)
  原英二
- Organizer
  日本血管生物医学会
- Place of Presentation
  東京
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Intrinsic cooperation between p16^<INK4a> and p21^<Waf1/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010
- Author(s)
  Takeuchi S., Takahashi A., Motoi N., Yoshimoto S., Tajima T., Yamakoshi K., Ishikawa Y., Sone S., Hara E., Ohtani N.
- Organizer
  Cold Spring Harbor Laboratory Meeting : Molecular Genetics of Aging
- Place of Presentation
  New York, U.S.A.
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] Real-time in vivo imaging of p16^<Ink4a> reveals cross-talk with p53.2010
- Author(s)
  原英二
- Organizer
  IMCB symposium on cell cycle regulation and tumorigenesis.
- Place of Presentation
  Singapore, Singapore
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] DNA damage dependent degradation of histone methyltransferase in cellular senescence.2010
- Author(s)
  Takahashi A., Yamakoshi K., Imai Y., Ohtani N., Hara E
- Organizer
  Cold Spring Harbor Laboratory Meeting : Molecular Genetics of Aging
- Place of Presentation
  New York, U.S.A.
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] Backup tumor suppressor role for p16^<INK4a> in the event of p53 inactivation2010
- Author(s)
  Takahashi A., Yamakoshi K., Ohtani N., Hara E
- Organizer
  日本分子生物学会・日本生化学会合同年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] 蛍光・発光融合プローブを用いたOct4遺伝子イメージングシステムの開発2010
- Author(s)
  田島丈子、杉田千鶴、近江谷克祐、中尾和貴、柳茂、深見希代子、原英二、大谷直子
- Organizer
  日本分子生物学会・日本生化学会合同年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] Cellular senescence: its role in tumor suppression and aging2010
- Author(s)
  原英二
- Organizer
  Asian aging core for longevity research
- Place of Presentation
  Jeju, Korea
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] 癌増殖における線維素溶解系因子の役割と新規治療法の開発2010
- Author(s)
  石原誠人、Beate Heissig, ほか
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際コンベンションセンター(大阪府大阪市)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-ORGANIZER-22112001
[Presentation] Cellular senescence : its role in tumor suppression and aging2010
- Author(s)
  Eiji Hara
- Organizer
  Asian aging core for longevity research
- Place of Presentation
  Jeju, South Korea
- Year and Date
  2010-08-22
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] 細胞老化において発癌を促進する因子の探索2010
- Author(s)
  今井良紀、高橋暁子、八尾良司、大谷直子、広田亨、田原栄俊、井出利憲、野田哲生、原英二
- Organizer
  日本癌学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] 細胞老化の分子メカニズムとその役割2010
- Author(s)
  原英二
- Organizer
  日本炎症・再生医学会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2010-08-05
- Data Source
  KAKENHI-PROJECT-21659083
[Presentation] 細胞老化の分子メカニズムとその役割2010
- Author(s)
  原英二
- Organizer
  日本炎症・再生医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] Real-time in vivo imaging of p16^<Ink4a> unveils a cross talk between p53 and p16^<Ink4a>2009
- Author(s)
  Eiji Hara
- Organizer
  IMCB Symposium on Cell Cycle Regulation & Tumorigenesis
- Place of Presentation
  シンガポールシンガポール市
- Data Source
  KAKENHI-PROJECT-21659083
[Presentation] Real-time in vivo imaging of p16Ink4a unveils a cross talk between p53 and p16Ink4a2009
- Author(s)
  Eiji Hara
- Organizer
  IMCB Symposium on Cell Cycle Regulation & Tumorigenesis
- Place of Presentation
  シンガポール
- Data Source
  KAKENHI-PROJECT-17013064
[Presentation] Real-time in vivo imaging of p16^<Ink4a> unveils a cross talk between p53 and p16^<Ink4a>2009
- Author(s)
  Eiji Hara
- Organizer
  IMCB Symposium on Cell Cycle Regulation & Tumorigenesis
- Place of Presentation
  シンガポールシンガポール市
- Data Source
  KAKENHI-PROJECT-17013064
[Presentation] Visualizing the dynamics of oncogenic stress response in living mice.2009
- Author(s)
  Ohtani N., Yamakoshi K., Takahashi A., Hara E
- Organizer
  AACR Conference on Mouse model of Cancer
- Place of Presentation
  San Francisco, U.S.A.
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] Real-time in vivo imaging of p16Ink4a unveils a cross talk between p53 and p16Ink4a2009
- Author(s)
  Kimi Yamakoshi, Akiko Takahashi, Naoko Ohtani, Eiji Hara
- Organizer
  The Salk Institute Meeting on Maechanisms and Models of Cancer
- Place of Presentation
  ラホヤ、アメリカ
- Data Source
  KAKENHI-PROJECT-17013064
[Presentation] Real-time in vivo imaging of p16^<Ink4a> expression unveils a cross-talk between p53 and p16^<Ink4a>2009
- Author(s)
  Yamakoshi K., Takahashi A., Ohtani N., Hara E
- Organizer
  The Salk Institute Meeting /Mechanisms & Models of Cancer
- Place of Presentation
  La Jolla, U.S.A.
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] Real-time in vivo imaging of p16^<Ink4a> unveils a cross talk between p53 and p16^<Ink4a>2009
- Author(s)
  Eiji Hara
- Organizer
  IMCB Symposium on Cell Cycle Regulation & Tumorigenesis
- Place of Presentation
  シンガポールシンガポール市
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] Real-time imaging of p16^<INK4a> expression visualizes the dynamics of senescence signaling in living mice2008
- Author(s)
  Eiji Hara
- Organizer
  日本分子生物学会・日本生化学会合同大会
- Place of Presentation
  神戸市ポートアイランド
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20659049
[Presentation] Real-time imaging of p16^<1NK4a> expression visualizes the dynamics of senescence slgnaling in living mice.2008
- Author(s)
  Eiji Hara
- Organizer
  日本分子生物学会・日本生化学会合同大会
- Place of Presentation
  神戸市ポートアイランド
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-17013064
[Presentation] Real-time imaging of p16^<INK4a> expression visualizes the dynamics of senescence signaling in living mice2008
- Author(s)
  Eiji Hara
- Organizer
  日本分子生物学会・日本生化学会合同大会
- Place of Presentation
  神戸市ポートアイランド
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] Real-time imaging of p16^<INK4a> expression visualizes the dynamics of senescence signalling in living animals.2008
- Author(s)
  Yamakoshi K., Takahashi A., Ohtani N., Hara E
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20390094
[Presentation] Real-time in vivo imaging of p16 tumor suppressor gene expression2007
- Author(s)
  原英二
- Organizer
  日本癌学会
- Place of Presentation
  横浜市
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-17013064
[Presentation] The role of p16Ink4a CDK inhibitor in cell cycle control and cellular senescence.2007
- Author(s)
  Eiji Hara
- Organizer
  Gene & Cancer Meeting
- Place of Presentation
  ウォーリック、イギリス
- Data Source
  KAKENHI-PROJECT-17013064
[Presentation] Mitogenic signaling and p16/Rb-pathway cooperate to enforce irreversible cellular senescence through activating ROS/PKC-δ signaling pathway2007
- Author(s)
  Akiko Takahashi, Naoko Ohtani, Kimi Yamakoshi, Eiji Hara
- Organizer
  Keystone Symposium
- Place of Presentation
  ウィスラー、カナダ
- Data Source
  KAKENHI-PROJECT-17013064
[Presentation] The role of p16 CDK inhibitor in cell cycle control and senescence2007
- Author(s)
  Eiji Hara
- Organizer
  Genes&Cancer 24^<th> Meeting
- Place of Presentation
  イギリス・Warwick市
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-18370080
[Presentation] The role of p16 CDK inhibitor in cell cycle control and senescence.2007
- Author(s)
  Eiji Hara
- Organizer
  Genes&Cancer 24th Meeting
- Place of Presentation
  イギリス・Warwick市
- Year and Date
  2007-12-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370080
[Presentation] The role of p16 CDK inhibitor in cell cycle control and senescence2007
- Author(s)
  Eiji, Hara
- Organizer
  Genes & Cancer 24th Meeting, December 12th
- Place of Presentation
  Warwick, UK
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370080
[Presentation] 細胞老化反応の生体内イメージング
- Author(s)
  大熊敦史、大谷直子、山越貴水、原　英二
- Organizer
  日本生化学会
- Place of Presentation
  京都市
- Year and Date
  2014-10-15 – 2014-10-17
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] Relationship between obesity, gut microbiome and HCC development
- Author(s)
  Eiji Hara
- Organizer
  Falk Gastro-Conference
- Place of Presentation
  Freiburg, Germany
- Year and Date
  2014-10-08 – 2014-10-11
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Obesity and cancer: a gut microbial connection
- Author(s)
  Eiji Hara
- Organizer
  日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] 細胞老化と発がん：腸内細菌の関与について
- Author(s)
  原英二
- Organizer
  日本肥満学会
- Place of Presentation
  宮崎
- Year and Date
  2014-10-23 – 2014-10-24
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Gut microbiota and fatty liver disease
- Author(s)
  Eiji Hara
- Organizer
  Gut microbiota for health world summit 2015
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-03-14 – 2015-03-15
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Obesity-induced gut microbial metabolite promotes liver cancer via senescence secretome
- Author(s)
  Eiji Hara
- Organizer
  Cold Spring Harbor Asia Conference
- Place of Presentation
  Suzhou, China
- Year and Date
  2014-05-19 – 2014-05-23
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] The roles and mechanisms of cellular senescence
- Author(s)
  Eiji Hara
- Organizer
  日本基礎老化学会
- Place of Presentation
  大府
- Year and Date
  2014-06-26 – 2014-06-27
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Cross-talk between the Rb^pathway and AKT signaling forms a quiescence-senescence switch
- Author(s)
  Eiji Hara
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Cellular senescence and cancer: a gut microbial connection
- Author(s)
  Eiji Hara
- Organizer
  Joint international symposium on TGF-b family and cancer signal network in tumor microenvironment
- Place of Presentation
  つくば
- Year and Date
  2015-01-12 – 2015-01-13
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] 細胞老化と炎症
- Author(s)
  原　英二
- Organizer
  日本炎症・再生医学会
- Place of Presentation
  沖縄県名護市
- Year and Date
  2014-07-01 – 2014-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] TGF-β signaling inhibitor eradicates chronic myelogenous leukemia stem cells
- Author(s)
  仲　一仁、石原薫理、定免由枝
- Organizer
  がん研究分野の特性等を踏まえた支援活動・公開シンポジウム
- Place of Presentation
  学術総合センター（東京都千代田区）
- Year and Date
  2015-01-27 – 2015-01-28
- Data Source
  KAKENHI-ORGANIZER-22112001
[Presentation] 細胞老化と炎症
- Author(s)
  原　英二
- Organizer
  日本動脈硬化学会
- Place of Presentation
  東京
- Year and Date
  2014-07-10 – 2014-07-12
- Invited
- Data Source
  KAKENHI-PROJECT-24650625
[Presentation] 細胞老化反応の生体内イメージング
- Author(s)
  大熊敦史、大谷直子、山越貴水、原　英二
- Organizer
  日本生化学会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-17
- Invited
- Data Source
  KAKENHI-PROJECT-24650625
[Presentation] 細胞老化と炎症
- Author(s)
  原英二
- Organizer
  日本動脈硬化学会
- Place of Presentation
  東京
- Year and Date
  2014-07-10 – 2014-07-11
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] Gut microbiota and fatty liver disease
- Author(s)
  Eiji Hara
- Organizer
  Gut microbiota for health world summit 2015
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2015-03-14 – 2015-03-15
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] 細胞老化と発癌：腸内細菌の関与について
- Author(s)
  原英二
- Organizer
  日本肥満学会
- Place of Presentation
  宮崎市
- Year and Date
  2014-10-23 – 2014-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] Relationship between obesity, gut microbiome and HCC development
- Author(s)
  Eiji Hara
- Organizer
  Falk Gastro-Conference
- Place of Presentation
  Freiburg, Germany
- Year and Date
  2014-10-08 – 2014-10-11
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] Obesity and cancer: a gut microbial connection
- Author(s)
  Eiji Hara
- Organizer
  日本免疫学会
- Place of Presentation
  京都市
- Year and Date
  2014-12-10 – 2014-12-12
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] 肥満と肝がん：腸内細菌の関与について
- Author(s)
  原英二
- Organizer
  酸化ストレスと肝研究会
- Place of Presentation
  福岡
- Year and Date
  2015-02-14 – 2015-02-15
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] The roles of cellular senescence in aging and cancer
- Author(s)
  Akiko Takahashi, Eiji Hara
- Organizer
  日本分子生物学会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-11-25 – 2014-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] Obesity-induced gut microbial metabolite promotes liver cancer via senescence secretome
- Author(s)
  Eiji Hara
- Organizer
  Cold Spring Harbor Asia Conference
- Place of Presentation
  Suzhou, China
- Year and Date
  2014-05-19 – 2014-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] The roles and mechanisms of cellular senescence
- Author(s)
  Eiji Hara
- Organizer
  日本基礎老化学会国際シンポジウム
- Place of Presentation
  愛知県大府市
- Year and Date
  2014-06-26 – 2014-06-27
- Invited
- Data Source
  KAKENHI-PROJECT-24650625
[Presentation] 細胞老化と炎症
- Author(s)
  原　英二
- Organizer
  日本動脈硬化学会
- Place of Presentation
  東京
- Year and Date
  2014-07-11 – 2014-07-12
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] 細胞老化と発癌
- Author(s)
  原　英二
- Organizer
  日本臨床分子医学会
- Place of Presentation
  東京
- Year and Date
  2014-04-12 – 2014-04-13
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] The roles of cellular senescence in aging and cancer
- Author(s)
  Akiko Takahashi & Eiji Hara
- Organizer
  日本分子生物学会シンポジウム
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-11-25 – 2014-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-24650625
[Presentation] 細胞老化と炎症
- Author(s)
  原　英二
- Organizer
  炎症・再生医学会シンポジウム
- Place of Presentation
  沖縄県名護市
- Year and Date
  2014-07-01 – 2014-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-24650625
[Presentation] 細胞老化と炎症
- Author(s)
  原英二
- Organizer
  日本炎症再生医学会
- Place of Presentation
  名護
- Year and Date
  2014-07-01 – 2014-07-03
- Invited
- Data Source
  KAKENHI-PLANNED-23112101
[Presentation] 細胞老化と発癌
- Author(s)
  原　英二
- Organizer
  日本臨床分子医学会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-04-12 – 2014-04-13
- Invited
- Data Source
  KAKENHI-PROJECT-24650625
[Presentation] 細胞老化と癌：細胞老化の功罪
- Author(s)
  原　英二
- Organizer
  高遠・分子細胞生物学シンポジウム
- Place of Presentation
  長野県伊那市
- Year and Date
  2014-08-28 – 2014-08-29
- Invited
- Data Source
  KAKENHI-PROJECT-24650625
[Presentation] Crosstalk between the Rb-pathway and AKT signaling forms a Quiescence- Senescence switch
- Author(s)
  Eiji Hara
- Organizer
  日本癌学会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] The roles and mechanisms of cellular senescence
- Author(s)
  Eiji Hara
- Organizer
  日本基礎老化学会国際シンポジウム
- Place of Presentation
  愛知県大府市
- Year and Date
  2014-06-26 – 2014-06-27
- Invited
- Data Source
  KAKENHI-PROJECT-26250028
[Presentation] Crosstalk between the Rb-pathway and AKT signaling forms a Quiescence- Senescence switch
- Author(s)
  Eiji Hara
- Organizer
  日本癌学会コアシンポジウム
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-24650625
[]

1. NAKAMURA Toshikazu (00049397)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KOSHIMIZU Uichi (50281126)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MATSUMOTO Kunio (90201780)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NEMOTO Yasuo (30250088)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OHTANI Naoko (50275195)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MIYAZONO Kohei (90209908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. AKIYAMA Tetsu (70150745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUJITA Naoya (20280951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. TAKAKURA Nobuyuki (80291954)

# of Collaborated Projects: 1 results

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10. SATO Yasufumi (50178779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. YANO Seiji (30294672)

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# of Collaborated Products: 1 results
12. KONDOH Shinae (40314182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MINAMI Takashi (00345141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HEISSIG Beate (30372931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. TABATA Yasuhiko (50211371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. ABURATANI Hiroyuki (10202657)

# of Collaborated Projects: 1 results

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17. MANO Hiroyuki (90240704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. NAKA Kazuhito (70372688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. KUBO Yoshiaki (10260069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
20. Goto Yuichi (00637902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. 船越洋 (40273685)

# of Collaborated Projects: 1 results

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22. 宮本一政 (60273679)

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23. 水野健作 (70128396)

# of Collaborated Projects: 1 results

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24. 盛真一郎 (00620519)

# of Collaborated Projects: 1 results

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25. 井戸章雄 (30291545)

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26. 喜多芳昭 (30570692)

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27. 杉浦剛 (40322292)

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28. 佐々木文郷 (40735297)

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29. 田辺寛 (40814306)

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30. 夏越祥次 (70237577)

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31. 比地岡浩志 (70305150)

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32. 大塚隆生 (20372766)

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33. TAKUBO Keiyo

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34. 河本新平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
35. 藤田直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
36. 中西真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 有田誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 有田正規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 杉本幸彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Eiji 原 英二

HARA Eiji 原 英二

原 英二 ハラ エイジ

Research Projects

Research Products

Co-Researchers

加齢性発癌の制御に向けた細胞老化の発癌促進作用の解明Principal Investigator

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Studies on the role of gut bacteria and cellular senescence in age-related carcinogenesis and its controlPrincipal Investigator

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Creation of colorectal cancer risk diagnosis and prevention concept by oral and colonic microbiome analysis

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Study of obesity-associated carcinogenesis and its application to cancer preventionPrincipal Investigator

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Understanding of the anti-apoptotic mechanisms in senescent cellsPrincipal Investigator

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Roles and mechanisms of cellular senescence in cancer microenvironmentPrincipal Investigator

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Study on senescence-associated tumor promotionPrincipal Investigator

Principal Investigator

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細胞老化の不可逆性を規定する分子機構の解明Principal Investigator

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Integrative Research on Cancer Microenvironment Network

Principal Investigator

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細胞老化の発癌制御に関する2面性とその調節に関する研究Principal Investigator

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Visualizing the dynamics of senescence response in vivoPrincipal Investigator

Principal Investigator

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分子イメージングを用いた新しい発癌リスク評価システムの開発Principal Investigator

Principal Investigator

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Research Institution

Studies on the irreversibility of cellular senescence and its role in vivoPrincipal Investigator

Principal Investigator

Hara Eiji 原英二

HARA Eiji 原英二

原英二ハラエイジ