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Yamagami Jun  山上 淳

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YAMAGAMI Jun  山上 淳

山上 淳  ヤマガミ ジュン

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Researcher Number 80327618
Other IDs
Affiliation (Current) 2025: 東京女子医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2025: 東京女子医科大学, 医学部, 准教授
2021 – 2023: 東京女子医科大学, 医学部, 准教授
2022: 慶應義塾大学, 医学部(信濃町), 講師
2016 – 2020: 慶應義塾大学, 医学部(信濃町), 講師
2013 – 2016: 慶應義塾大学, 医学部, 講師
2011 – 2014: 慶應義塾大学, 医学部, 助教
2005 – 2006: 慶應義塾大学, 医学部, 嘱託(非常勤)
Review Section/Research Field
Principal Investigator
Basic Section 53050:Dermatology-related / Dermatology
Except Principal Investigator
Dermatology / Medium-sized Section 53:Organ-based internal medicine and related fields / Surgical dentistry
Keywords
Principal Investigator
自己反応性B細胞 / 天疱瘡 / 自己抗体 / 自己免疫疾患 / 自己免疫 / 単一細胞解析 / B細胞 / 濾胞ヘルパーT細胞 / 脱毛 / デスモゾーム … More / 免疫学 / 細胞・組織 / ノックアウトマウス / カドヘリン / モデルマウス / デスモグレイン4 / 脱毛症 … More
Except Principal Investigator
天疱瘡 / 免疫寛容 / デスモグレイン3 / 癌 / 免疫学 / ドラッグデリバリーシステム / 細胞内シグナル / 脂質ラフト / デスモゾーム / 尋常性天疱瘡 / デスモグレイン / 自己免疫 / 免疫制御機構 / 腫瘍免疫 / コレステロール代謝 / がん免疫療法 / 免疫寛容機構 / 自己免疫疾患 / T細胞 / 免疫制御 / 蛋白質 / EGFR / デスモグレイン3 / 口腔癌 / エンドサイトーシス / マウスモデル / 抗体 / アトランタ / 米国 / 国際情報交換 / 経皮免疫 / ランゲルハンス細胞 / 樹状細胞 / 皮膚免疫 Less
  • Research Projects

    (13 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (11 People)
  •  単一細胞解析を統合した新たな天疱瘡の病勢評価法と治療標的の開発Principal Investigator

    • Principal Investigator
      山上 淳
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Tokyo Women's Medical University
  •  Elucidation of mechanism of autoantibody production in pemphigus in conjunction with information from single cell analysisPrincipal Investigator

    • Principal Investigator
      山上 淳
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Tokyo Women's Medical University
  •  Analysis on a new immunoregulatory mechanism to control pathogenic T cell repertoires

    • Principal Investigator
      TAKAHASHI Hayato
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Keio University
  •  Elucidating pathophysiology of pemphigus by single cell analysis of auto-reactive B cellsPrincipal Investigator

    • Principal Investigator
      Yamagami Jun
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Tokyo Women's Medical University
      Keio University
  •  Oral cancer treatment by targeted drug delivery system with an anti-desmoglein monoclonal antiboby

    • Principal Investigator
      Kouno Michiyoshi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Tokyo Dental College
  •  Elucidation of the role of lipid rafts in the pathophysiology of pemphigus vulgaris

    • Principal Investigator
      Saito Masataka
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Clarification of peripheral tolerance mechanism involved in the onset of autoimmune skin diseases

    • Principal Investigator
      Amagai Masayuki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Analysis of the activation mechanism of autoreactive B cells in pemphigusPrincipal Investigator

    • Principal Investigator
      Yamagami Jun
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Development of the skin-targeted drug delivery system by using non-pathogenic pemphigus antibody

    • Principal Investigator
      Kouno Michiyoshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Tokyo Dental College
  •  ランゲルハンス細胞が誘導する経皮液性免応答の制御機構

    • Principal Investigator
      永尾 圭介
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Elucidation of the mechanism by which pemphigus vulgaris autoantibodies cause cellular signaling in human keratinocytes

    • Principal Investigator
      SAITO Masataka
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  Analysis of autoantibodies in pemphigus using phage displayPrincipal Investigator

    • Principal Investigator
      YAMAGAMI Jun
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University
  •  モデルマウスを用いた毛包分化におけるデスモグレイン4の機能解析Principal Investigator

    • Principal Investigator
      山上 淳
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Dermatology
    • Research Institution
      Keio University

All 2023 2022 2021 2020 2019 2017 2016 2015 2014 2013 2012

All Journal Article Presentation Book

  • [Book] Immunology of the Skin2016

    • Author(s)
      Yamagami J, Takahashi H, Amagai M.
    • Total Pages
      504
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-26253065
  • [Journal Article] Desmoglein-Specific B-Cell-Targeted Single-Cell Analysis Revealing Unique Gene Regulation in Patients with Pemphigus2023

    • Author(s)
      Egami Shohei、Watanabe Takashi、Fukushima-Nomura Ayano、Nomura Hisashi、Takahashi Hayato、Yamagami Jun、Ohara Osamu、Amagai Masayuki
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 143 Issue: 10 Pages: 1919-1928

    • DOI

      10.1016/j.jid.2023.03.1661

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K08416
  • [Journal Article] Clinical Severity scores as a guide for prediction of initial treatment responses in pemphigus and pemphigoid patients.2023

    • Author(s)
      Tanaka R, Kurihara Y, Egami S, Saito Y, Ouchi T, Funakoshi T, Takahashi H, Umegaki-Arao N, Kubo A, Tanikawa A, Amagai M, Yamagami J.
    • Journal Title

      J Dermatol.

      Volume: 50 Issue: 2 Pages: 203-211

    • DOI

      10.1111/1346-8138.16532

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K08416
  • [Journal Article] Rituximab therapy for intractable pemphigus: A multicenter, open-label, single-arm, prospective study of 20 Japanese patients.2023

    • Author(s)
      Yamagami J, Kurihara Y, Funakoshi T, Saito Y, Tanaka R, Takahashi H, Ujiie H, Iwata H, Hirai Y, Iwatsuki K, Ishii N, Sakurai J, Abe T, Takemura R, Mashino N, Abe M, Amagai M.
    • Journal Title

      J Dermatol.

      Volume: 50 Issue: 2 Pages: 175-182

    • DOI

      10.1111/1346-8138.16597

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08416, KAKENHI-PROJECT-22K08419, KAKENHI-PROJECT-21K18227
  • [Journal Article] IgM to IgG Class Switching Is a Necessary Step for Pemphigus Phenotype Induction in Desmoglein 3?Specific B Cell Receptor Knock-in Mouse2022

    • Author(s)
      Nomura Hisashi、Wada Naoko、Takahashi Hayato、Kase Yuko、Yamagami Jun、Egami Shohei、Iriki Hisato、Mukai Miho、Kamata Aki、Ito Hiromi、Fujii Hideki、Ishikura Tomoyuki、Koseki Haruhiko、Watanabe Takashi、Yamada Taketo、Ohara Osamu、Koyasu Shigeo、Amagai Masayuki
    • Journal Title

      The Journal of Immunology

      Volume: 208 Issue: 3 Pages: 582-593

    • DOI

      10.4049/jimmunol.2100781

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01051, KAKENHI-PROJECT-19H03519
  • [Journal Article] Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus2021

    • Author(s)
      Iriki H, et al.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 118 Issue: 49

    • DOI

      10.1073/pnas.2026763118

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22526, KAKENHI-PROJECT-18H04025, KAKENHI-PROJECT-19H01051, KAKENHI-PROJECT-21H04801
  • [Journal Article] Neonatal Linear IgA Bullous Dermatosis Mediated by Breast Milk-Borne Maternal IgA2021

    • Author(s)
      Egami S, Suzuki C, Kurihara Y, Yamagami J, Kubo A, Funakoshi T, Nishie W, Matsumura K, Matsushima T, Kawaida M, Sakamoto M, Amagai M
    • Journal Title

      JAMA Dermatol.

      Volume: 157 Issue: 9 Pages: 1107-1111

    • DOI

      10.1001/jamadermatol.2021.2392

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03683
  • [Journal Article] Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell?mediated inflammation in the skin2021

    • Author(s)
      Takahashi H.、Nomura H.、Iriki H.、Kubo A.、Isami K.、Mikami Y.、Mukai M.、Sasaki T.、Yamagami J.、Kudoh J.、Ito H.、Kamata A.、Kurebayashi Y.、Yoshida H.、Yoshimura A.、Sun H. W.、Suematsu M.、O’Shea J. J.、Kanno Y.、Amagai M.
    • Journal Title

      Science Immunology

      Volume: 6 Issue: 64

    • DOI

      10.1126/sciimmunol.abb6444

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07627, KAKENHI-PROJECT-21H05044, KAKENHI-PROJECT-19H01051, KAKENHI-PROJECT-20H03666
  • [Journal Article] Analysis of clinical characteristics, prognosis and antibody pathogenicity of pemphigus patients positive for anti‐desmoglein IgG autoantibodies in remission: a retrospective cohort study2021

    • Author(s)
      Zhao W.L.、Ishii K.、Egami S.、Xu Z.、Funakoshi T.、Takahashi H.、Tanikawa A.、Ishiko A.、Amagai M.、Yamagami J.
    • Journal Title

      Journal of the European Academy of Dermatology and Venereology

      Volume: 36 Issue: 2 Pages: 271-278

    • DOI

      10.1111/jdv.17770

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01051, KAKENHI-PROJECT-19H03683
  • [Journal Article] Autoimmune bullous skin diseases, pemphigus and pemphigoid.2020

    • Author(s)
      Shohei Egami, Jun Yamagami, Masayuki Amagai
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 145 Issue: 4 Pages: 1031-1047

    • DOI

      10.1016/j.jaci.2020.02.013

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03683
  • [Journal Article] Pemphigus2017

    • Author(s)
      Kasperkiewicz M, Ellebrecht CT, Takahashi H, Yamagami J, Zillikens D, Payne AS, Amagai M
    • Journal Title

      Nature Reviews Disease Primers

      Volume: 印刷中

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253065
  • [Journal Article] Validation of chemiluminescent enzyme immunoassay in detection of autoantibodies in pemphigus and pemphigoid.2017

    • Author(s)
      Fujio Y, Kojima K, Hashiguchi M, Wakui M, Murata M, Amagai M, Yamagami J.
    • Journal Title

      J Dermatol Sci

      Volume: 85 Issue: 3 Pages: 208-215

    • DOI

      10.1016/j.jdermsci.2016.12.007

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26253065
  • [Journal Article] Evaluation of pharyngo-oesophageal involvement in pemphigus vulgaris and its correlation with disease activity2017

    • Author(s)
      Okamura A, Nakamura R, Yamagami J, Ishii K, Kawakubo H, Omori T, Takeuchi H, Amagai M, Kitagawa Y.
    • Journal Title

      Br J Dermatol

      Volume: 176 Issue: 1 Pages: 224-226

    • DOI

      10.1111/bjd.14725

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26253065
  • [Journal Article] Low pathogenicity of anti-desmoglein 3 immunoglobulin G autoantibodies contributes to the atypical clinical phenotypes in pemphigus2015

    • Author(s)
      Saleh MA, Hashimoto R, Kase Y, Amagai M, Yamagami J
    • Journal Title

      J Dermatol

      Volume: 42 Issue: 7 Pages: 685-689

    • DOI

      10.1111/1346-8138.12888

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253065
  • [Journal Article] 天疱瘡:抗デスモグレイン抗体2014

    • Author(s)
      山上淳, 天谷雅行
    • Journal Title

      分子リウマチ治療

      Volume: 7 Pages: 113-116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26253065
  • [Journal Article] Autoimmune reactivity against precursor form of desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus2013

    • Author(s)
      Toumi A, Saleh MA, Yamagami J, Abida O, Kallel M, Masmoudi A, Makni S, Turki H, Hachiya T, Kuroda K, Stanley JR, Masmoudi H, Amagai M
    • Journal Title

      J Dermatol Sci

      Volume: 70(1) Issue: 1 Pages: 19-25

    • DOI

      10.1016/j.jdermsci.2013.02.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229014, KAKENHI-PROJECT-23791291
  • [Journal Article] Pathogenic anti-desmoglein 3 mAbs cloned from a paraneoplastic pemphigus patient by phage display2012

    • Author(s)
      Saleh MA, Ishii K, Yamagami J, Shirakata Y, Hashimoto K, Amagai M
    • Journal Title

      J Invest Dermatol

      Volume: 132(4) Issue: 4 Pages: 1141-1148

    • DOI

      10.1038/jid.2011.449

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229014, KAKENHI-PROJECT-23591628, KAKENHI-PROJECT-23791291
  • [Presentation] Autoantigen-specific B cells targeted single-cell RNA-seq reveals the functional heterogeneity in pemphigus patients2021

    • Author(s)
      Shohei Egami, Takashi Watanabe, Ayano Nomura-Fukushima, Hisashi Nomura, Hayato Takahashi, Jun Yamagami, John R Stanley, Osamu Ohara, Masayuki Amagai
    • Organizer
      The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01051
  • [Presentation] 天疱瘡モデルマウスの抗デスモグレイン3抗体産生においてIL-27p28は重要な役割を果たす2020

    • Author(s)
      鎌田亜紀, 高橋勇人, 吉田裕樹, 伊藤宏美, 山上淳, 天谷雅行
    • Organizer
      第41回日本炎症・再生医学会
    • Data Source
      KAKENHI-PROJECT-19H01051
  • [Presentation] IL-27 plays an important role in anti-desmoglein 3 antibody production in pemphigus vulgaris mouse model.2020

    • Author(s)
      Aki Kamata, Hayato Takahashi, Hiroki Yoshida, Jun Yamagami, Masayuki Amagai
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H01051
  • [Presentation] Single-cell RNA-seq reveals the transcriptional landscape and heterogeneity of auto reactive B cells in pemphigus patients2019

    • Author(s)
      Shohei Egami, Takashi Watanabe, Hisashi Nomura, Hayato Takahashi, Jun Yamagami, Osamu Ohara, Masayuki Amagai
    • Organizer
      44th JSID annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03683
  • [Presentation] FcgRllb is critical to establish clonal ignorance and suppress pemphigus phenotype in pathogenic anti-desmoglein 3 antibody knock-in mice2016

    • Author(s)
      Nomura H, Kase Y, Yamagami J, Wada N, Koyasu S, Takahashi H, Amagai M
    • Organizer
      41st Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      仙台国際センター(宮城県仙台市青葉区)
    • Year and Date
      2016-12-09
    • Data Source
      KAKENHI-PROJECT-26253065
  • [Presentation] Intravenous immunoglobulin regulates anti-desmoglein 3 autoantibody production in B220- antibody-producing cells in mice with pemphigus vulgaris2015

    • Author(s)
      Kase Y, Yamagami J, Wada N, Takahashi H, Koyasu S, Amagai M
    • Organizer
      45th Annual Meeting of the European Society for Dermatological Research
    • Place of Presentation
      Rotterdam (The Netherlands)
    • Year and Date
      2015-09-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253065
  • [Presentation] Characterization of the population like follicular helper T cells in the peripheral blood in patients with pemphigus2015

    • Author(s)
      Yamagami J, Kamata A, Amagai M
    • Organizer
      The 40th Annual Meeting of Japanese Society for Investigative Dermatology
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2015-12-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461710
  • [Presentation] Antibodies against desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus are mostly against the precursor molecule.2012

    • Author(s)
      Toumi A, Saleh MA, Yamagami J, Abida O, Kallel M, Masmoudi A, Marki S, Turki H, Hachiya T, Kuroda K, Stanley JR, Masmoudi H, Amagai M
    • Organizer
      The 75th Annual meeting of Society for Investigative Dermatology
    • Place of Presentation
      ノースカロライナ州ローリー,米国)
    • Year and Date
      2012-05-09
    • Data Source
      KAKENHI-PROJECT-23791291
  • [Presentation] 風土病型落葉状天疱瘡の発症前におけるデスモグレイン1前駆体に対する抗体2012

    • Author(s)
      山上淳, Toumi A, Saleh MA, 蜂矢隆久, 黒田慶子, Stanley JR, Masmoudi H, 天谷雅行
    • Organizer
      第19回分子皮膚科学フォーラム
    • Place of Presentation
      青森
    • Year and Date
      2012-04-13
    • Data Source
      KAKENHI-PROJECT-23791291
  • [Presentation] Antibodies against desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus are mostly against the precursor molecule2012

    • Author(s)
      Jun Yamagami
    • Organizer
      2012 Society for Investigative Dermatology annual Meeting
    • Place of Presentation
      Raleigh, North Carolina, USA
    • Data Source
      KAKENHI-PROJECT-23791291
  • 1.  TAKAHASHI HAYATO (40398615)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 13 results
  • 2.  AMAGAI Masayuki (90212563)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 11 results
  • 3.  SAITO Masataka (30306774)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  Kouno Michiyoshi (30403182)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  舩越 建 (80365353)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  KOWALCZYK AP
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  永尾 圭介 (40286521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  久保 亮治 (70335256)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  谷口 智憲 (40424163)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  渡辺 貴志 (50406815)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  吉田 裕樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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