Akita HIdetaka 秋田英万

… Alternative Names

Akita Hidetaka 秋田英万

AKITA Hidetaka 秋田英万

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Researcher Number	80344472
Other IDs
External Links
Affiliation (Current)	2025: 東北大学, 薬学研究科, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 東北大学, 薬学研究科, 教授 2016 – 2021: 千葉大学, 大学院薬学研究院, 教授 2015: 北海道大学, 薬学研究科(研究院), 准教授 2012: 北海道大学, 大学院・薬学研究院, 准教授 2011: 北海道大学, 大学院薬学研究院, 准教授 … More 2011: Hokkaido University, 薬学研究科(研究院), 助教 2009 – 2010: 北海道大学, 大学院・薬学研究院, 准教授 2007 – 2009: Hokkaido University, Fac Pharm. Sci, Associate Professor 2006: 北海道大学, 大学院薬学研究院, 助手 2006: 北海道大学, 大学院薬学研究院, 助手 2003 – 2005: 北海道大学, 大学院・薬学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields / Physical pharmacy / Biomedical engineering/Biological material science / Science and Engineering / Medical pharmacy / Pharmaceutical Sciences and related fields / Biomedical engineering/Biomaterial science and engineering Except Principal Investigator Biomedical engineering/Biological material science / Drug development chemistry / Biological Sciences … More / Medical pharmacy / Pharmaceutical Sciences and related fields / Plastic surgery / Biomedical engineering/Biomaterial science and engineering / Respiratory organ internal medicine / Physical pharmacy Less
Keywords	Principal Investigator 細胞内動態 / 癌治療 / DDS / 癌免疫 / ナノ粒子 / 細胞内動態制御 / 遺伝子デリバリー / 脂質様材料 / 癌免役 / ナノマシン … More / ナノバイオ / ワクチン / ナノ材料 / トランスサイトーシス / リアルタイムイメージング / アデノウイルス / 人工ベクター / 遺伝子治療 / RNA創剤 / RNA創薬 / 標的化 / がん抗原 / RNA / 脂質ナノ粒子 / ネオ抗原 / 凍結乾燥 / ＲＮＡワクチン / RNAワクチン / 炎症 / 体内動態 / 核酸 / エンドソーム脱出 / プロドラッグ / ＤＤＳ / 脾臓 / 抗炎症薬 / 脂質 / リガンド / 癌 / ドラッグデリバリーシステム / ＤＮＡ / 薬学 / 遺伝子 / DNA / 環境応答性材料 / 自己組織化 / 遺伝子・核酸デリバリー / 肺 / リポソーム / 極性細胞 / heterogeneity / mRNA検出 / 定量化 / 核膜透過 / 核膜誘過 / エンドサイトーシス脱出 … More Except Principal Investigator 遺伝子治療 / MEND / siRNA / オクタアルギニン / ミトコンドリア / 核酸医薬 / 非ウイルスベクター / 人工遺伝子デリバリーシステム / KALA / 細胞内動態制御 / 核内動態制御 / 核内動態 / 外来DNA / 非ウィルスベクター / アジュバント / 抗腫瘍効果 / ワクチン / ハイドロダイナミクス法 / 多機能性エンベロープ型ナノ構造体 / 遺伝子デリバリー / がん / 転写リプログラミング / がんドラッグデリバリーシステム / がん型OATP1B3 / がん分子標的治療 / ドラッグデリバリー / がん分子標的 / ナノ粒子 / drug delivery system / 定量評価 / リンパ管細静脈吻合 / リンパ菅 / リンパ節 / DDS / リンパ外科 / リンパ管静脈吻合 / カニュレーション / 超音波 / リンパ管 / リンパ浮腫 / 薬物送達システム / Nrf2 / 多機能性エンベロープナノ構造体 / transgene expression / intranuclear disposition / gene therapy / exogenous DNA / nonviral vector / 発現効率 / programmed packaging / octaarginin / endocytosis / gene delivery system / 定量的評価 / アデノウイルス / 細胞内動態 / ソーティング素子 / 細胞内シグナル / スイツチ / スイッチ / ウイルスベクター / 樹状細胞 / DNAワクチン / スイッチ機能 / 機能性核酸 / 核送達 / パッケージング / バイセル / 自己活性化システム / ミトコンドリア送達 / 還元環境応答性 / pH-感受性カチオニック脂質 / ナノパッケージング / マイクロ流路 / ナノマシン / 抗原提示 / MHCクラス-I / 細胞透過性ペプチド / 細胞性免疫 / ナノ構造体 / トポロジー / エンドソーム脱出 / PPD / デリバリーシステム / R8-NEND / カベオラ / IRO / GALA / 遺伝子デリバリーシステム / 遺伝子診断 / 網羅的解析 / 2型糖尿病 / 血管透過 / トランスサイトーシス / エンドサイトーシス / PPD-MEND / がん治療 / MMP / 遺伝子導入 / 細胞内ターゲティング / 多重型 / オルガネラターゲティング / MTS Less

Innovation of On-demand DDS platform of RNA therapeutics based on endothelial ATLASPrincipal Investigator
- Principal Investigator
  
  秋田英万
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Tohoku University
Ready-tp-Use RNA-drug discovery for the acceleration of personalized cancer vaccinePrincipal Investigator
- Principal Investigator
  
  秋田英万
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Tohoku University
  Chiba University
Development of self-assembly prodrug: Application to the cancer therapy by reset of immune-cyclePrincipal Investigator
- Principal Investigator
  
  Akita Hidetaka
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Tohoku University
  Chiba University
Development of nanoDDS for cancer therapy without anti-cancer drug: Proposal of RISET therapy and its therapeutic functionPrincipal Investigator
- Principal Investigator
  
  Akita Hidetaka
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Chiba University
Development of the nanoDDS platform for the penetrarion or intracellular delivery: Develioment of the rapid ligand-identification system and in vivo control of intracellular traffickingPrincipal Investigator
- Principal Investigator
  
  Akita Hidetaka
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  Chiba University
Percutaneous Access to the Lymphatic System Using Ultrasonography and Translymphatic DDS Using Nanoparticles
- Principal Investigator
  
  Akita Shinsuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Chiba University
Development of cancer suicide gene therapy using RNA trans-splicing technology
- Principal Investigator
  
  Furihata Tomomi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  Chiba University
Debelopment of nano satelite-organized archetecture as a technology to control an intracellular traffickingPrincipal Investigator
- Principal Investigator
  
  Akita Hidetaka
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
  Hokkaido University
Innovation of multi-Drug delivery platform based on the ssPalm: Immune-engineering and cancer therapyPrincipal Investigator
- Principal Investigator
  
  Hidetaka Akita
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Chiba University
  Hokkaido University
Challenge for treatment of refractory lung diseases using a multifunctional envelope-type nanodevice that targets the lung endothelium
- Principal Investigator
  
  Nishimura Masaharu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Development of nanomachine for mitochondrial gene therapy targeted to cells derived from mitochondrial disease patients
- Principal Investigator
  
  YAMADA Yuma
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Hokkaido University
MENDで拓く遺伝子治療への道：遺伝子の運び屋からナノマシンへ
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Novel gene delivery system with switch function
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
肺血管標的及び透過型DDSを目的としたナノ粒子のインビボ細胞内動態制御法の確立Principal Investigator
- Principal Investigator
  
  秋田英万
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Hokkaido University
Control of intranuclear disposition of DNA for gene therapy
- Principal Investigator
  
  KAMIYA Hiroyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Ehime University
Multifunctional Envelope-type Nano Device as non-viral gene delivery system for cancer therapy
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
細胞内動態の精密制御に基づいたナノキャリアのトランスサイトーシス輸送制御の新戦略Principal Investigator
- Principal Investigator
  
  秋田英万
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Hokkaido University
抗原提示バランスとアジュバントの制御に基づいたオーダーメイド癌ワクチン
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
DNA・mRNAの細胞内高感度可視化情報に基づく高性能人工遺伝子べクターの創製Principal Investigator
- Principal Investigator
  
  秋田英万
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
Development of new-generation gene vectors by a control of intracellular trafficking and dispersion based in a real-time imaging of DNAPrincipal Investigator
- Principal Investigator
  
  AKITA Hidetaka
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Hokkaido University
がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
1分子イメージングに基づく細胞内動態・解離制御型デリバリーシステムの創製Principal Investigator
- Principal Investigator
  
  秋田英万
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
Development of in vivo gene delivery system for siRNA and genome wide screening of type-two diabetes related genes in mice and rats
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Hokkaido University
Novel DNAs for efficient and durable transgene expression
- Principal Investigator
  
  KAMIYA Hiroyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
ミトコンドリアを標的とする多重型・多機能性エンベロープ型ナノ構造体の開発
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
ウイルスの細胞内動態定量化情報に基づいた人工遺伝子ベクター開発の新規アプローチPrincipal Investigator
- Principal Investigator
  
  秋田英万
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
核膜透過過程の新規定量化システムの構築と核膜輸送の基質認識性、機能多様性の解析Principal Investigator
- Principal Investigator
  
  秋田英万
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
Development of Multifunctional Envelope type Nano Device based on Programmed Packaging
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  HOKKAIDO UNIVERSITY

[Book] ドラッグキャリア設計入門～DDSからナノマシンまで～2018
- Author(s)
  秋田　英万
- Total Pages
  21
- Publisher
  丸善出版
- Data Source
  KAKENHI-PROJECT-17K19473
[Book] Nonviral Vectors for Gene Therapy (Vol. 88): Lipid- and Polymer-based Gene Transfer2014
- Author(s)
  Yusuke Sato, Takashi Nakamura, Yuma Yamada, Hidetaka Akita, Hideyoshi Harashima
- Total Pages
  428
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26282131
[Book] Delivery of Nucleic Acids and Gene Delivery2011
- Author(s)
  H.Akita, H.Hatakeyama, I.A.Khalil, Y.Yamada, H.Harashima
- Total Pages
  34
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-22229001
[Book] バイオテクノロジーシリーズ蛍光イメージング/MRIプローブの開発2011
- Author(s)
  秋田英万、山田勇磨,中村孝司、畠山浩人、林泰弘、梶本和昭、原島秀吉
- Total Pages
  10
- Publisher
  CMC出版
- Data Source
  KAKENHI-PROJECT-22229001
[Book] A Novel Nonviral Gene Delivery System : Multifunctional Envelope-type Nano Device2010
- Author(s)
  H.Hatakeyama, H.Akita, et al
- Total Pages
  33
- Publisher
  T.Scheper, Volume Editors I.Endo and T.Nagamune, Springer
- Data Source
  KAKENHI-PROJECT-22659006
[Book] Adv Biochem Eng Biotechnol(A Novel Nonviral Gene Delivery System: Multifunctional Envelope-Type Nano Device.)2009
- Author(s)
  H.Hatakeyama, H.Akita, K.Kogure, H.Harashima
- Data Source
  KAKENHI-PROJECT-20015003
[Book] Contrib Nephrol (Nonviral gene delivery)2008
- Author(s)
  Akita H, Harashima H.
- Total Pages
  19
- Publisher
  KARGER
- Data Source
  KAKENHI-PROJECT-18200032
[Book] 分子薬物動態学(第17章高分子・遺伝子の体内動態の制御(細胞内動態を中心に))2008
- Author(s)
  秋田英万、原島秀吉
- Total Pages
  19
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-18200032
[Book] 1Pharmacokinetics of Gene Delivery in Cells. In Non-viral Gene Therapy: Gene Design and Delivery Edit. by Kazunari Taira, Kazunori Kataoka,2005
- Author(s)
  H.Akita, I.A Khalil, K.Kogure, H.Harashima.
- Total Pages
  19
- Publisher
  Springer-Verlag Tokyo, Inc.
- Data Source
  KAKENHI-PROJECT-17659039
[Book] "New Drug Delivery System and Application to Gene Therapy" Knaeblein, Muller Eds. Modern Biopharmaceuticals.2005
- Author(s)
  K.Kogure, H.Akita, H.Kamiya, H.Harashima.
- Total Pages
  15
- Publisher
  Wiley-VCH
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] The Effect of Cholesterol Content on the Adjuvant Activity of Nucleic-Acid-Free Lipid Nanoparticles2024
- Author(s)
  Anindita Jessica、Tanaka Hiroki、Yamakawa Takuma、Sato Yuka、Matsumoto Chika、Ishizaki Kota、Oyama Taiji、Suzuki Satoko、Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu、Sasaki Kasumi、Ogura Yumika、Yonemochi Etsuo、Sakurai Yu、Hatakeyama Hiroto、Akita Hidetaka
- Journal Title
  
  Pharmaceutics
  
  Volume: 16 Issue: 2 Pages: 181-181
- DOI
  10.3390/pharmaceutics16020181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18320, KAKENHI-PROJECT-21K18035
[Journal Article] 国産の核酸・RNA創薬への挑戦：細胞内・生体内・そして地球内の動態を制御するDDS開発をめざして2023
- Author(s)
  秋田英万
- Journal Title
  
  製剤機械技術学会
  
  Volume: 32(2) Pages: 87-94
- Data Source
  KAKENHI-PROJECT-21K18320
[Journal Article] An Ionizable Lipid Material with a Vitamin E Scaffold as an mRNA Vaccine Platform for Efficient Cytotoxic T Cell Responses2023
- Author(s)
  Oyama Ryotaro、Ishigame Harumichi、Tanaka Hiroki、Tateshita Naho、Itazawa Moeko、Imai Ryosuke、Nishiumi Naomasa、Kishikawa Jun-ichi、Kato Takayuki、Anindita Jessica、Nishikawa Yoshifumi、Maeki Masatoshi、Tokeshi Manabu、Tange Kota、Nakai Yuta、Sakurai Yu、Okada Takaharu、Akita Hidetaka
- Journal Title
  
  ACS Nano
  
  Volume: 17 Issue: 19 Pages: 18758-18774
- DOI
  10.1021/acsnano.3c02251
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18320, KAKENHI-PROJECT-20KK0152, KAKENHI-PROJECT-21K18035
[Journal Article] Reactivation of Anticancer Immunity by Resetting Interorgan Crosstalk in Immune-Suppressive Cells with a Nanoparticulated Anti-Inflammatory Drug2023
- Author(s)
  Doi M, Tanaka H, Ohoto T, Miura N, Sakurai Y, Hatakeyama H, Akita H
- Journal Title
  
  Small
  
  Volume: - Issue: 16
- DOI
  10.1002/smll.202205131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18320, KAKENHI-PROJECT-21K18035
[Journal Article] Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA2023
- Author(s)
  Tanaka Hiroki、Hagiwara Shinya、Shirane Daiki、Yamakawa Takuma、Sato Yuka、Matsumoto Chika、Ishizaki Kota、Hishinuma Miho、Chida Katsuyuki、Sasaki Kasumi、Yonemochi Etsuo、Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu、Tadokoro Takashi、Maenaka Katsumi、Taneichi Sakura、et al.
- Journal Title
  
  ACS Nano
  
  Volume: 17 Issue: 3 Pages: 2588-2601
- DOI
  10.1021/acsnano.2c10501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06545, KAKENHI-PROJECT-21K18320, KAKENHI-PROJECT-21K18035
[Journal Article] siRNA delivery to lymphatic endothelial cells via ApoE-mediated uptake by lipid nanoparticles2023
- Author(s)
  Sakurai Y, Yoshikawa K, Arai K, Kazaoka A, Aoki S, Ito K, Nakai Y, Tange K, Furihata T, Tanaka H, Akita H
- Journal Title
  
  J Control Release
  
  Volume: 353 Pages: 122-135
- DOI
  10.1016/j.jconrel.2022.11.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18320
[Journal Article] Development of a Ready-to-Use-Type RNA Vaccine Carrier Based on an Intracellular Environment-Responsive Lipid-like Material with Immune-Activating Vitamin E Scaffolds2023
- Author(s)
  Anindita Jessica、Tanaka Hiroki、Oyama Ryotaro、Hagiwara Shinya、Shirane Daiki、Taneichi Sakura、Nakai Yuta、Tange Kota、Hatakeyama Hiroto、Sakurai Yu、Akita Hidetaka
- Journal Title
  
  Pharmaceutics
  
  Volume: 15 Issue: 12 Pages: 2702-2702
- DOI
  10.3390/pharmaceutics15122702
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18320, KAKENHI-PROJECT-21K18035
[Journal Article] Delivering mRNA to Secondary Lymphoid Tissues by Phosphatidylserine‐Loaded Lipid Nanoparticles2022
- Author(s)
  Masaki Gomi, Yu Sakurai, Minami Sato, Hiroki Tanaka, Yumi Miyatake, Koichi Fujiwara, Mizuki Watanabe, Satoshi Shuto, Yuta Nakai, Kota Tange, Hiroto Hatakeyama, Hidetaka Akita
- Journal Title
  
  Advanced Healthcare Materials
  
  Volume: 12 Issue: 9 Pages: 2202528-2202528
- DOI
  10.1002/adhm.202202528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06494, KAKENHI-PROJECT-21K18320, KAKENHI-PROJECT-19K06965, KAKENHI-PROJECT-22KJ0465
[Journal Article] Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material2021
- Author(s)
  Tanaka Hiroki、Takata Nae、Sakurai Yu、Yoshida Tokuyuki、Inoue Takao、Tamagawa Shinya、Nakai Yuta、Tange Kota、Yoshioka Hiroki、Maeki Masatoshi、Tokeshi Manabu、Akita Hidetaka
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 4 Pages: 544-544
- DOI
  10.3390/pharmaceutics13040544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06811, KAKENHI-PROJECT-20K20195, KAKENHI-PROJECT-20H00657, KAKENHI-PROJECT-20K12726, KAKENHI-PROJECT-21K06468
[Journal Article] Improvement of mRNA Delivery Efficiency to a T Cell Line by Modulating PEG-Lipid Content and Phospholipid Components of Lipid Nanoparticles2021
- Author(s)
  Tanaka Hiroki、Miyama Ryo、Sakurai Yu、Tamagawa Shinya、Nakai Yuta、Tange Kota、Yoshioka Hiroki、Akita Hidetaka
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 12 Pages: 2097-2097
- DOI
  10.3390/pharmaceutics13122097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20195, KAKENHI-PROJECT-20H00657, KAKENHI-PROJECT-21K18035
[Journal Article] Toxoplasma gondii GRA15 DNA Vaccine with a Liposomal Nanocarrier Composed of an SS-Cleavable and pH-Activated Lipid-like Material Induces Protective Immunity against Toxoplasmosis in Mice2021
- Author(s)
  Hasan T, Kawanishi R, Akita H, Nishikawa Y
- Journal Title
  
  Vaccines
  
  Volume: 10 Issue: 1 Pages: 21-21
- DOI
  10.3390/vaccines10010021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18320, KAKENHI-PROJECT-20K21359, KAKENHI-PROJECT-20KK0152
[Journal Article] Self‐Degradable Lipid‐Like Materials Based on “Hydrolysis accelerated by the intra‐Particle Enrichment of Reactant (HyPER)” for Messenger RNA Delivery2020
- Author(s)
  Tanaka Hiroki、...Sakurai Yu、Ueda Keisuke、Higashi Kenjirou、Moribe Kunikazu、Shinsho Eiji、Nishida Ruka、Fukuzawa Kaori、Yonemochi Etsuo、Okuwaki Koji、Mochizuki Yuji、Nakai Yuta、Tange Kota、Yoshioka Hiroki、Tamagawa Shinya、Akita Hidetaka
- Journal Title
  
  Advanced Functional Materials
  
  Volume: 30 Issue: 34 Pages: 1910575-1910575
- DOI
  10.1002/adfm.201910575
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20195, KAKENHI-PROJECT-18K18377, KAKENHI-PROJECT-20H00657
[Journal Article] Vitamin E Scaffolds of pH-Responsive Lipid Nanoparticles as DNA Vaccines in Cancer and Protozoan Infection.2020
- Author(s)
  Maeta M, Miura N, Tanaka H, Nakamura T, Kawanishi R, Nishikawa Y, Asano K, Tanaka M, Tamagawa S, Nakai Y, Tange K, Yoshioka H, Harashima H, Akita H.
- Journal Title
  
  Mol Pharm.
  
  Volume: 17 Issue: 4 Pages: 1237-1247
- DOI
  10.1021/acs.molpharmaceut.9b01262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21359, KAKENHI-PROJECT-20KK0152, KAKENHI-PROJECT-18K18377, KAKENHI-PROJECT-20H00657, KAKENHI-PROJECT-20H03473
[Journal Article] Silencing of VEGFR2 by RGD-Modified Lipid Nanoparticles Enhanced the Efficacy of Anti-PD-1 Antibody by Accelerating Vascular Normalization and Infiltration of T Cells in Tumors2020
- Author(s)
  Cho Riki、Sakurai Yu、Jones Haleigh Sakura、Akita Hidetaka、Hisaka Akihiro、Hatakeyama Hiroto
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 12 Pages: 3630-3630
- DOI
  10.3390/cancers12123630
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20195, KAKENHI-PROJECT-19H03387, KAKENHI-PROJECT-20H00657
[Journal Article] Intraoperative Detection of Efferent Lymphatic Vessels Emerging from Lymph Node during Lymphatic Microsurgery2019
- Author(s)
  Yamaji Yoshihisa、Kuriyama Motone、Tokumoto Hideki、Ishigaki Tatsuya、Tezuka Takafumi、Ogata Hideyuki、Kubota Yoshitaka、Mitsukawa Nobuyuki、Akita Shinsuke
- Journal Title
  
  Journal of Reconstructive Microsurgery
  
  Volume: Epub ahead of print Issue: 05 Pages: 372-378
- DOI
  10.1055/s-0038-1677039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11529
[Journal Article] Development of a mouse model for the visual and quantitative assessment of lymphatic trafficking and function by in vivo imaging2018
- Author(s)
  Yamaji Yoshihisa、Akita Shinsuke、Akita Hidetaka、Miura Naoya、Gomi Masaki、Manabe Ichiro、Kubota Yoshitaka、Mitsukawa Nobuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1
- DOI
  10.1038/s41598-018-23693-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11529, KAKENHI-PROJECT-16K20351
[Journal Article] The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds.2018
- Author(s)
  Tanaka H, Watanabe A, Konishi M, Nakai Y, Yoshioka H, Ohkawara T, Takeda H, Harashima H, Akita H.
- Journal Title
  
  Heliyon
  
  Volume: 4 Issue: 12 Pages: e00959-e00959
- DOI
  10.1016/j.heliyon.2018.e00959
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05500, KAKENHI-PROJECT-18K18377, KAKENHI-PROJECT-17K19473
[Journal Article] In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular Administration.2018
- Author(s)
  Tanaka H, Nakatani T, Frihata T, Tange K, Nakai Y, Yoshioka H, Harashima H, Akita H.
- Journal Title
  
  Mol Pharm
  
  Volume: 15 Issue: 5 Pages: 2060-2067
- DOI
  10.1021/acs.molpharmaceut.7b01084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18377, KAKENHI-PROJECT-17K19473
[Journal Article] Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology.2018
- Author(s)
  Sun Y, Pinon Hofbauer J, Harada M, Woss K, Koller U, Morio H, Stierschneider A, Kitamura K, Hashimoto M, Chiba K, Akita H, Anzai N, Reichelt J, Bauer JW, Guttmann-Gruber C, Furihata T.
- Journal Title
  
  Cancer Letters
  
  Volume: 433 Pages: 107-116
- DOI
  10.1016/j.canlet.2018.06.032
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19475
[Journal Article] A hepatic pDNA delivery system based on an intracellular environment sensitive vitamin E-scaffold lipid-like material with the aid of an anti-inflammatory drug.2018
- Author(s)
  Togashi R, Tanaka H, Nakamura S, Yokota H, Tange K, Nakai Y, Yoshioka H, Harashima H, Akita H
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 279 Pages: 262-270
- DOI
  10.1016/j.jconrel.2018.04.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18377, KAKENHI-PROJECT-17K19473
[Journal Article] Innovative technologies in Nanomedicines: from passive targeting to active targeting/from controlled pharmacokinetics to controlled intracellular pharmacokinetics.2017
- Author(s)
  Sato Y, Sakurai Y, Kajimoto K, Nakamura T, Yamada Y, Akita H, Harashima H.
- Journal Title
  
  Macromolecular Bioscience
  
  Volume: 17 Issue: 1 Pages: 1-16
- DOI
  10.1002/mabi.201600179
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26282132, KAKENHI-PROJECT-26713002, KAKENHI-PROJECT-26670741, KAKENHI-PROJECT-15K20831, KAKENHI-PROJECT-16K11180
[Journal Article] Modifying Antigen-Encapsulating Liposomes with KALA Facilitates MHC Class I Antigen Presentation and Enhances Anti-tumor Effects.2017
- Author(s)
  Miura N, Akita H, Tateshita N, Nakamura T, Harashima H.
- Journal Title
  
  Mol Ther
  
  Volume: 印刷中 Issue: 4 Pages: 1003-1013
- DOI
  10.1016/j.ymthe.2017.01.020
- NAID
  120006425607
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H01806, KAKENHI-PROJECT-15J01221
[Journal Article] Temperature and pH sensitivity of a stabilized self-nanoemulsion formed using an ionizable lipid-like material via an oil-to-surfactant transition.2017
- Author(s)
  Tanaka H, Oasa S, Kinjo M, Tange K, Nakai Y, Harashima H, Akita H
- Journal Title
  
  Colloids Surf B Biointerfaces
  
  Volume: 151 Pages: 95-101
- DOI
  10.1016/j.colsurfb.2016.11.020
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H01806, KAKENHI-PROJECT-14J02588, KAKENHI-PROJECT-15K14934
[Journal Article] Identification of a Nucleoporin358-Specific RNA Aptamer for Use as a Nucleus-Targeting Liposomal Delivery System.2016
- Author(s)
  Shrivastava G, Hyodo M, Yoshimura SH, Akita H, Harashima H
- Journal Title
  
  Nucleic Acid Ther
  
  Volume: 26（５） Pages: 286-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H01806
[Journal Article] Transcytosis-Targeting Peptide: A Conductor of Liposomal Nanoparticles through the Endothelial Cell Barrier.2016
- Author(s)
  Akita H, Fujiwara T, Santiwarangkool S, Hossen N, Kajimoto K, El-Sayed A, Tabata Y, Harashima H.
- Journal Title
  
  Small
  
  Volume: 12 Issue: 9 Pages: 1212-1221
- DOI
  10.1002/smll.201500909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H01806, KAKENHI-PROJECT-26282132
[Journal Article] Cellular environment-responsive nanomaterials for use in gene and siRNA delivery: molecular design for biomembrane destabilization and intracellular collapse.2016
- Author(s)
  Tanaka H, Sato Y, Harashima H, Akita H.
- Journal Title
  
  Expert Opin Drug Deliv.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14934
[Journal Article] Effect of particle size on their accumulation in an inflammatory lesion in a dextran sulfate sodium (DSS)-induced colitis model.2016
- Author(s)
  Watanabe A, Tanaka H, Sakurai Y, Tange K, Nakai Y, Ohkawara T, Takeda H, Harashima H, Akita H.
- Journal Title
  
  Int J Pharm
  
  Volume: 509(1-2) Issue: 1-2 Pages: 118-122
- DOI
  10.1016/j.ijpharm.2016.05.043
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H01806, KAKENHI-PROJECT-14J02588, KAKENHI-PROJECT-15K14934
[Journal Article] Cellular environment-responsive nanomaterials for use in gene and siRNA delivery: molecular design for biomembrane destabilization and intracellular collapse2016
- Author(s)
  Tanaka H, Sato Y, Harashima H, Akita H
- Journal Title
  
  Expert Opin Drug Deliv.
  
  Volume: 13(7) Issue: 7 Pages: 1015-1027
- DOI
  10.1517/17425247.2016.1154531
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H01806, KAKENHI-PROJECT-15K14934
[Journal Article] Cellular environment-responsive nanomaterials for use in gene and siRNA delivery: molecular design for biomembrane destabilization and intracellular collapse.2016
- Author(s)
  Tanaka H, Sato Y, Harashima H, Akita H.
- Journal Title
  
  Expert Opin Drug Deliv
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H01806
[Journal Article] Molecular tuning of a vitamin E-scaffold pH-sensitive and reductive cleavable lipid-like material for accelerated in vivo hepatic siRNA delivery2015
- Author(s)
  Akita, H. Noguchi Y, Hatakeyama H, Tange K, Nakai Y, Harashima H
- Journal Title
  
  ACS Biomater Sci Eng.
  
  Volume: 1 Issue: 9 Pages: 834-844
- DOI
  10.1021/acsbiomaterials.5b00203
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14934, KAKENHI-PROJECT-15H01806
[Journal Article] Effect of hydrophobic scaffold on the cellular uptake and gene transfection activities of DNA-encapsulating liposomal nanoparticles via intracerebroventricular administration.2015
- Author(s)
  Akita H, Nakatani T, Kuroki K, Maenaka K, Tange K, Nakai Y, Harashima H.
- Journal Title
  
  Int J Pharm
  
  Volume: 490 Issue: 1-2 Pages: 142-145
- DOI
  10.1016/j.ijpharm.2015.05.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H01806
[Journal Article] Effect of the Compaction and the Size of DNA on the Nuclear Transfer Efficiency after Microinjection in Synchronized Cells2015
- Author(s)
  Akita H, Kurihara D, Schmeer M, Schleef M, Harashima H.
- Journal Title
  
  Pharmaceutics
  
  Volume: 7 Issue: 2 Pages: 64-73
- DOI
  10.3390/pharmaceutics7020064
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01806
[Journal Article] Particle tracking analysis for the intracellular trafficking of nanoparticles modified with African swine fever virus protein p54-derived peptide2013
- Author(s)
  Akita H, Enoto K, Tanaka H, Harashima H
- Journal Title
  
  Molecular Therapy
  
  Volume: 21(2) Issue: 2 Pages: 309-317
- DOI
  10.1038/mt.2012.235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Stearylated INF7 peptide enhances endosomal escape and gene expression of PEGylated nanoparticles both in vitro and in vivo2012
- Author(s)
  El-Sayed A, Masuda T, Akita H, Harashima H
- Journal Title
  
  J Pharm Sci.
  
  Volume: 101(2) Issue: 2 Pages: 879-882
- DOI
  10.1002/jps.22807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00421, KAKENHI-PROJECT-22229001
[Journal Article] A Multifunctional Envelope-type Nanodevice for Use in Nanomedicine: Concept and Applications2012
- Author(s)
  Nakamura T, Akita H, Yamada Y, Hatakeyama H, Harashima H
- Journal Title
  
  Acc Chem Res
  
  Volume: 45(7) Issue: 7 Pages: 1113-1121
- DOI
  10.1021/ar200254s
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PUBLICLY-24107502
[Journal Article] Effect of the Anchor in Polyethylene Glycol-Lipids on the Transfection Activity of PEGylated Cationic Liposomes Encapsulating DNA2012
- Author(s)
  Kusumoto K, Akita H, El-Sayed A, Harashima H
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 35 Issue: 4 Pages: 445-448
- DOI
  10.1248/bpb.35.445
- NAID
  130001872189
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10F00421, KAKENHI-PROJECT-22229001
[Journal Article] Improving in vivo hepatic transfection activity by controlling intracellular trafficking : the function of GALA and maltotriose2011
- Author(s)
  Akita H, Masuda T, Nishio T, Niikura K, Ijiro K, Harashima H
- Journal Title
  
  Mol Pharm
  
  Volume: 8(4) Issue: 4 Pages: 1436-1442
- DOI
  10.1021/mp200189s
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-22350076, KAKENHI-PROJECT-22655050, KAKENHI-PROJECT-22655059
[Journal Article] KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine2011
- Author(s)
  Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yamashita A, Katoono R, Yui N, Harashima H
- Journal Title
  
  Biomaterials
  
  Volume: 32(26) Issue: 26 Pages: 6342-6350
- DOI
  10.1016/j.biomaterials.2011.05.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-22659006
[Journal Article] Dual imaging of mRNA and protein production : an investigation of the mechanism of heterogeneity in cationic lipid-mediated transgene expression2011
- Author(s)
  Akita H, Umetsu Y, Kurihara D, Harashima H
- Journal Title
  
  Int J Pharm
  
  Volume: 415(1-2) Issue: 1-2 Pages: 218-220
- DOI
  10.1016/j.ijpharm.2011.05.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Quantitative analysis of condensation/decondensation status of pDNA in the nuclear sub-domains by QD-FRET.2011
- Author(s)
  Shaheen SM, Akita H, et al
- Journal Title
  
  H.Nucleic Acids Res.
  
  Volume: (印刷中)
- NAID
  120002989236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659006
[Journal Article] Functional improvement of an I.RQ-PEG-MEND for delivering genes to the lung2011
- Author(s)
  Ishitsuka T, Akita H, Harashima H
- Journal Title
  
  J Control Release
  
  Volume: 154(1) Issue: 1 Pages: 77-83
- DOI
  10.1016/j.jconrel.2011.05.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] KALA-modified multi-layered nano- particles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine2011
- Author(s)
  Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yamashita A, Katoono R, Yui N, Harashima H
- Journal Title
  
  Biomaterials
  
  Volume: 32(26) Pages: 6342-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659006
[Journal Article] Cell penetrating peptide-mediated systemic siRNA delivery to the liver2011
- Author(s)
  Hayashi Y, Yamauchi J, Khalil IA, Kajimoto K, Akita H, Harashima H
- Journal Title
  
  Int J Pharm
  
  Volume: 419(1-2) Issue: 1-2 Pages: 308-313
- DOI
  10.1016/j.ijpharm.2011.07.038
- NAID
  120003504743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23790038
[Journal Article] A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response2011
- Author(s)
  Hatakeyama H, Ito E, Yamamoto M, Akita H, Hayashi Y, Kajimoto K, Kaji N, Baba Y, Harashima H
- Journal Title
  
  Mol Ther
  
  Volume: 19(8) Pages: 1487-98
- NAID
  120003762627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659006
[Journal Article] Leptin-derived peptide, a targeting ligand for mouse brain-derived endothelial cells via macropinocytosis.2010
- Author(s)
  Tamaru M, Akita H, Fujiwara T, Kajimoto K, Harashima H.
- Journal Title
  
  Biochem Biophys Res Commun. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650072
[Journal Article] Particle Tracking of Intracellular Trafficking of Octaarginine-modified Liposomes : A Comparative Study With Adenovirus2010
- Author(s)
  Akita H, Enoto K, Masuda T, Mizuguchi H, Tani T, Harashima H.
- Journal Title
  
  Mol Ther (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Intracellular fate of octaarginine-modified liposomes in polarized MDCK cells2010
- Author(s)
  Fujiwara T, Akita H, Harashima H.
- Journal Title
  
  Int J Pharm 386
  
  Pages: 122-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Particle Tracking of Intracellular Trafficking of Octaarginine-modified Liposomes : A Comparative Study With Adenovirus.2010
- Author(s)
  Akita H, Enoto K, Masuda T, Tani T, Mizuguchi H, Harashima H
- Journal Title
  
  Mol Ther
  
  Volume: 18(5) Pages: 955-964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689002
[Journal Article] Intracellular fate of octaarginine-modified liposomes in polarized MDCK cells.2010
- Author(s)
  Fujiwara T, Akita H, Harashima H.
- Journal Title
  
  Int J Pharm 386
  
  Pages: 122-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650072
[Journal Article] Intracellular fate of octaarginine- modified liposomes in polarized MDCK cells.2010
- Author(s)
  T.Fujiwara, H.Akita, H.Harashima
- Journal Title
  
  Int J Pharm 386
  
  Pages: 122-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines : Programmed endosomal escape and dissociation2010
- Author(s)
  Akita H, Kogure K, Moriguchi R, Nakamura Y, Higashi T, Nakamura T, Serada S, Fujimoto M, Naka T, Futaki S, Harashima H.
- Journal Title
  
  J Control Release. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Leptin-derived peptide, a targeting ligand for mouse brain-derived endothelial cells via macropinocytosis.2010
- Author(s)
  Tamaru M, Akita H, Fujiwara T, Kajimoto K, Harashima H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 394(3) Pages: 311-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22689002
[Journal Article] Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines : Programmed endosomal escape and dissociation2010
- Author(s)
  Akita H, et al.
- Journal Title
  
  J.Cont.Rel. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancervaccines : Programmed endosomal escape and dissociation.2010
- Author(s)
  Akita H, Kogure K, et al
- Journal Title
  
  J Control Release.
  
  Volume: 143 Pages: 311-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Novel Lipidated Sorbitol-based Molecular Transporters for Non-viral Gene Delivery2009
- Author(s)
  Higashi T, Khalil IA, Maiti KK, Lee WS, Akita H, Harashima H, Chung SK.
- Journal Title
  
  J Control Release (in press)
- NAID
  120001390961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a steo-wise membrane fusion process.2009
- Author(s)
  H.Akita, A.Kudo, A.Minoura, M.Yamaguchi, IA.Khalil, R.Moriguchi, T.Masuda, R.Danev, K.Nagayama, K.Kogure, H.Harashima
- Journal Title
  
  Biomaterials 30
  
  Pages: 2940-2949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Multilayered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process2009
- Author(s)
  H. Akita, A. Kudo, A. Minoura, M. Ya maguchi, I. A Khalil, R. Moriguchi, T. Masuda, R. Danev, K. Nagayama, K. Ko gure and H. Harashima.
- Journal Title
  
  Biomaterials (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process.2009
- Author(s)
  H.Akita, et al.
- Journal Title
  
  Biomaterials 30(15)
  
  Pages: 2940-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription2009
- Author(s)
  Masuda, T., Akita, H., Niikura, K., Nishio, T., Ukawa, M., Enoto, K., Danev, R., Nagayama, K., Ijiro, K., Harashima, H
- Journal Title
  
  Biomaterials 30
  
  Pages: 4806-4814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Efficient siRNA delivery to tumor cells using the combination of octaarginine, GALA and tumor-specific, cleavable PEG system.2009
- Author(s)
  Y.Sakurai, H.Hatakeyama, H.Akita, M.Oishi, Y.Nagasaki, S.Futaki, H.Harashima
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 928-932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription.2009
- Author(s)
  T.Masuda, H.Akita, K.Niikura, T.Nishio, M.Ukawa, K.Enoto, R.Danev, K.Nagayama, K.Ijiro, H.Harashima
- Journal Title
  
  Biomaterials 30
  
  Pages: 4806-4814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process2009
- Author(s)
  H. Akita, A. Kudo, A. Minoura, M. Yamaguchi, I. A. Khalil, R. Moriguchi, T. Masuda, R. Danev, K. Nagayama, K. Kogure and H. Harashima.
- Journal Title
  
  Biomaterials 30(15)
  
  Pages: 2940-9
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process.2009
- Author(s)
  H. Akita, A. Kudo, A. Minoura, M. Yamaguchi, I. A Khalil, R. Moriguchi, T. Masuda, R. Danev, K. Nagayama, K. Kogure, H. Harashima
- Journal Title
  
  Biomaterials 30(15)
  
  Pages: 2940-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.2009
- Author(s)
  H.Hatakeyama, E.Ito, H.Akita, M.Oishi, Y.Nagasaki, S.Futaki, H.Harashima
- Journal Title
  
  J.Control.Release 139
  
  Pages: 127-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process.2009
- Author(s)
  H.Akita, A.Kudo, A.Minoura, M.Yamaguchi, I.A Khalil, R.Moriguchi, T.Masuda, R.Danev, K.Nagayama, K.Kogure, H.Harashima
- Journal Title
  
  Biomaterials 30
  
  Pages: 2940-2949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape.2009
- Author(s)
  El-Sayed A, Masuda T, Khalil I, Akita H, Harashima H.
- Journal Title
  
  J Control Release. 138(2)
  
  Pages: 160-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Envelope-type lipid nanoparticles incorporating a short PEG-lipid conjugate for improved control of intracellular trafficking and transgene transcription.2009
- Author(s)
  Masuda T, Akita H, Niikura K, Nishio T, Ukawa M, Enoto K, Danev R, Nagayama K, Ijiro K, Harashima H.
- Journal Title
  
  Biomaterials 30(27)
  
  Pages: 4806-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Development of lipid particles targeted via sugar-lipid conjugates as novel nuclear gene delivery system2008
- Author(s)
  T. Masuda, H. Akita, T. Nishio, K. Niikura, K. Kogure, K. Ijiro, H. Harashima.
- Journal Title
  
  Biomaterials 29
  
  Pages: 709-723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway2008
- Author(s)
  Diky Mudhakir, H. Akita, E. Tan, H. Harashima.
- Journal Title
  
  J Controlled Rel 125
  
  Pages: 164-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Photosensitized breakage and damage of DNA by CdSe-ZnS quantum dots2008
- Author(s)
  Anas A, Akita H, Harashima H, Itoh T, Ishikawa M, Biju. V.
- Journal Title
  
  J Phys Chem B 112
  
  Pages: 10005-10011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021003
[Journal Article] A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway2008
- Author(s)
  D.Mudhakir, H.Akita, E.Tan, H.Harashima
- Journal Title
  
  J Controlled Rel. 125(2)
  
  Pages: 164-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Advances in non-viral gene delivery : using multifunctional envelope-type nano device2008
- Author(s)
  H. Akita and H. Harashima.
- Journal Title
  
  Expert Opinion on Drue Delivery 5
  
  Pages: 847-859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650072
[Journal Article] Oligosaccharide-Mediated Nuclear Transport of Nanoparticles2008
- Author(s)
  K. Niikura, S. Sekiguchi, T. Nishio, T. Masuda, H. Akita, Y. Matsuo, K.Kogure, H. Harashima. K. Iiiro
- Journal Title
  
  Chembiochem 9
  
  Pages: 2623-2627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Supramolecular control of polyplex dissociation and cell transfection : efficacy of amino groups and threading cyclodextrins in biocleavable polyrotaxanes2008
- Author(s)
  Yamashita A, Kinda D, Katoono R, Yui N, Ooya T, Maruyama A, Akita H, Kogure K, Harashima H.
- Journal Title
  
  J Control Release 131
  
  Pages: 137-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021003
[Journal Article] Development of lipid particles targeted via sugar-lipid conjugates as novel nuclear gene delivery system.2008
- Author(s)
  T.Masuda, H.Akita, T.Nishio, K.Niikura, A.Kudo, K.Kogure, K.Ijiro, H.Harashima
- Journal Title
  
  Biomaterials 29
  
  Pages: 709-723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] MITO-Porter: a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion2008
- Author(s)
  Y. Yamada, H. Akita, H. Kamiya, K. Kogure, T. Yamamoto, Y. Shinohara, K. Yamashita, H. Kobayashi, H. Kikuchi, and H. Harashima
- Journal Title
  
  Biochim. Biophys. Acra (In press)
- NAID
  120000952609
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390034
[Journal Article] MITO-Porter: a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion.2008
- Author(s)
  Y. Yamada, H. Akita, H. Kamiya, K. Kogure, T. Yamamoto, Y. Shinohara, K. Yamashita, H. Kobayashi, H. Kikuchi, and H. Harashima
- Journal Title
  
  Biochim. Biophys. Acta. (In press)
- NAID
  120000952609
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390034
[Journal Article] A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway.2008
- Author(s)
  D. Mudhakir, H. Akita, E. Tan, H. Harashima
- Journal Title
  
  J Control Release 125(2)
  
  Pages: 164-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex.2007
- Author(s)
  S.Hama, H.Akita, S.Iida, H.Mizuguchi, H.Harashima
- Journal Title
  
  Nucleic Acids Res. 35
  
  Pages: 1533-1543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Cell-cycle dependent transcription, a determinant factor of heterogeneity in cationic lipid-mediated transgene expression2007
- Author(s)
  H.Akita, R.Ito, H.Kamiya, K.Kogure, H.Harashima
- Journal Title
  
  J. Gene Med. (in press)
- NAID
  120000973870
- Data Source
  KAKENHI-PROJECT-18390034
[Journal Article] Cell cycle- dependent transcription, a determinant factor of heterogeneity in cationic lipid-mediated transgene expression.2007
- Author(s)
  H. Akita, R. Ito, H. Kamiya, K. Kogure, and H. Harashima
- Journal Title
  
  J. Gene Med. 9
  
  Pages: 197-207
- NAID
  120000973870
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390034
[Journal Article] Octaarginine-modified envelope-type nanoparticles for gene delivery. Gene Therapy nanoparticles for gene delivery2007
- Author(s)
  I. A. Khalil, K. Kogure, S. Futaki, S. Hama, H. Akita, K. Kataoka, and H. Harashima
- Journal Title
  
  Gene Therapy 14(8)
  
  Pages: 682-9
- Data Source
  KAKENHI-PROJECT-18200032
[Journal Article] Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex2007
- Author(s)
  S. Hama, H. Akita, S. Iida, H. Mizuguchi and H. Harashima
- Journal Title
  
  Nucl. Acids Res. 35
  
  Pages: 1533-1543
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390034
[Journal Article] Cell-cycle dependent transcription, a determinant factor of heterogeneity in cationic lipid-mediated transgene expression2007
- Author(s)
  H. Akita, R. Ito, H. Kamiya, K. Kogure, and H. Harashima:
- Journal Title
  
  J. Gene Med 9
  
  Pages: 197-207
- NAID
  120000973870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021003
[Journal Article] Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex.2007
- Author(s)
  S. Hama, H. Akita, S. Iida, H. Mizuguchi and H. Harashima
- Journal Title
  
  Nucl. Acids Res. 35
  
  Pages: 1533-1543
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390034
[Journal Article] Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex.2007
- Author(s)
  Hama S, Akita H, Mizuguchi H, Hayakawa Y, Harashima H
- Journal Title
  
  Nucleic Acids Res (In press)
- Data Source
  KAKENHI-PROJECT-17790110
[Journal Article] Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex.2007
- Author(s)
  Hama S, Akita H, Mizuguchi H, Hayakawa Y, Harashima H
- Journal Title
  
  Nucleic Acids Res (In press)
- Data Source
  KAKENHI-PROJECT-18038001
[Journal Article] Cell cycle dependent transcription, a determinant factor of heterogeneity in cationic lipid-mediated transgene expression2007
- Author(s)
  H. Akita, R. Ito, H. Kamiya, K. Kogure, and H. Harashima
- Journal Title
  
  J. Gene Med. 9
  
  Pages: 197-207
- NAID
  120000973870
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390034
[Journal Article] Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems.2006
- Author(s)
  Hama S, Akita H, Mizuguchi H, Hayakawa Y, Harashima H
- Journal Title
  
  Mol Ther 13(4)
  
  Pages: 786-794
- Data Source
  KAKENHI-PROJECT-17790110
[Journal Article] Evaluation of the nuclear delivery and intra-nuclear transcription of the plasmid DNA condensed with m (mu) and NLS-m by cytoplasmic and nuclear microinjection : comparative study with poly L-lysine.2006
- Author(s)
  H.Akita
- Journal Title
  
  J. Gen.Med. 8・2
  
  Pages: 198-206
- Data Source
  KAKENHI-PROJECT-18015004
[Journal Article] Pharmacokinetic analysis of the tissue distribution of octaarginine modified liposomes in mice2005
- Author(s)
  D.Mudhakir, H.Akita, I.A.Khalil, S.Futaki, H.Harashima
- Journal Title
  
  Drug Metab Pharmacokinet 20
  
  Pages: 275-281
- NAID
  130004933331
- Data Source
  KAKENHI-PROJECT-17790110
[Journal Article] Evaluation of nuclear transfer and transcription of plasmid DNA condensed with protamine by microinjection : the use of a nuclear transfer score.2005
- Author(s)
  T.Masuda, H.Akita, H.Harashima
- Journal Title
  
  FEBS Lett 579
  
  Pages: 2143-2148
- Data Source
  KAKENHI-PROJECT-17790110
[Journal Article] A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids2005
- Author(s)
  R.Moriguchi, K.Kogure, H.Akita, S.Futaki, M.Miyagishi, K.Taira, H.Harashima
- Journal Title
  
  Int J Pharm 301
  
  Pages: 277-285
- Data Source
  KAKENHI-PROJECT-17790110
[Journal Article] Development of an efficient method for packaging oligodeoxynucleotides in a condensed nano particle with a lipid-envelope structure.2005
- Author(s)
  Y.Yamada, K.Kogure, Y.Nakamura, K.Inoue, H.Akita, F.Ngatsugi, S.Sasaki, T.Suhara, H.Harashima.
- Journal Title
  
  Biol. Pharm. Bull. 28・10
  
  Pages: 1939-1942
- Data Source
  KAKENHI-PROJECT-17659039
[Journal Article] Development of efficient packaging method of oligodeoxynucleotides by a condensed nano particle in lipid envelope structure.2005
- Author(s)
  Y.Yamada, K.Kogure, Y.Nakamura, K.Inoue, H.Akita, F.Nagatsugi, S.Sasaki, T.Suhara, H.Harashima
- Journal Title
  
  Biol Pharm Bull 28
  
  Pages: 1939-1942
- NAID
  110003666368
- Data Source
  KAKENHI-PROJECT-17790110
[Journal Article] Sunflower-shaped cyclodextrin-conjugated poly(epsilon-lysine) polyplex as a controlled intracellular trafficking device.2005
- Author(s)
  H.S.Choi, A.Yamashita, T.Ooya, N.Yui, H.Akita, K.Kogure, R.Ito, H.Harashima.
- Journal Title
  
  Chembiochem 6
  
  Pages: 1986-1990
- Data Source
  KAKENHI-PROJECT-17790110
[Journal Article] Quantitative three-dimesional analysis of the intracellular trafficking of plasmid DNA transfected by non-viral gene delivery system using confocal laser scanning microscopy.2004
- Author(s)
  H.Akita
- Journal Title
  
  Mol.Ther. 9
  
  Pages: 443-451
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300151
[Journal Article] Quantitative three-dimesional analysis of the intracellular trafficking of plasmid DNA transfected by non-viral gene delivery system using con focal laser scanning microscopy.2004
- Author(s)
  H.Akita
- Journal Title
  
  Mol.Ther. 9
  
  Pages: 443-451
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300151
[Journal Article] Quantitative three dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivary system using confocal laser scanning microscopy2004
- Author(s)
  Akita H, Ito R, Khalil I, Futaki S, Harashima H
- Journal Title
  
  Mol Ther 9(3)
  
  Pages: 443-450
- Data Source
  KAKENHI-PROJECT-15790084
[Journal Article] Pharmacokinetic and pharmacodynamic considerations in gene therapy2003
- Author(s)
  Kamiya H, Akita H, Harashima H
- Journal Title
  
  Drug Discovery Today 18(21)
  
  Pages: 990-996
- Data Source
  KAKENHI-PROJECT-15790084
[Journal Article]
- Author(s)
  H.Akita, K.Kogure, R.Moriguchi, Y.Nakamura, T.Higashi, T.Nakamura, S.Serada, M.Fujimoto, T.Naka, S.Futaki, H.Harashima
- Journal Title
  
  J.Control.Release (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015003
[Journal Article] Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines
- Author(s)
  H.Akita, K.Kogure, R.Moriguchi, Y.Nakamura, T.Higashi, T.Nakamura, S.Serada, M.Fujimoto, T.Naka, S.Futaki, H.Harashima
- Journal Title
  
  Programmed endosomal escape and dissociation (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Particle Tracking of Intracellular Trafficking of Octaarginine-modified Liposomes: A Comparative Study With Adenovirus.
- Author(s)
  H.Akita, K.Enoto, T, Masuda, H.Mizuguchi, T.Tani, H.Harashima
- Journal Title
  
  Mol Ther. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680025
[Journal Article] Multi-layered nano particles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process
- Author(s)
  H. Akita
- Journal Title
  
  Biomaterials (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] 細胞内動態を改善した新規カチオン性脂質2018
- Inventor(s)
  秋田英万、田中浩揮、高田奈依、高橋達也、小西真奈美
- Industrial Property Rights Holder
  秋田英万、田中浩揮、高田奈依、高橋達也、小西真奈美
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-17K19473
[Patent] 組換え発現ベクター及び当該ベクターを封入した脂質膜構造体2016
- Inventor(s)
  原島秀吉, 山田勇磨, 石川卓哉, 秋田英万
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2016-11-28
- Overseas
- Data Source
  KAKENHI-PROJECT-26282131
[Patent] Ｏ／Ｗ型エマルション2015
- Inventor(s)
  原島秀吉、秋田英万、田中浩揮、渡邊綾香など７名
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-200148
- Filing Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K14934
[Patent] Ｏ／Ｗ型エマルション2015
- Inventor(s)
  原島秀吉、秋田英万、田中浩揮など
- Industrial Property Rights Holder
  原島秀吉、秋田英万、田中浩揮など
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-200148
- Filing Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15H01806
[Patent] 組換え発現ベクター及び当該ベクターを封入した脂質膜構造体2015
- Inventor(s)
  原島秀吉、山田勇磨、石川卓哉、秋田英万
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-230498
- Filing Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26282131
[Patent] 結合剤およびその利用2012
- Inventor(s)
  原島秀吉、林泰弘、秋田英万、鳥谷部尚之、富樫亮平
- Industrial Property Rights Holder
  原島秀吉、林泰弘、秋田英万、鳥谷部尚之、富樫亮平
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-174272
- Filing Date
  2012-08-06
- Data Source
  KAKENHI-PROJECT-22229001
[Patent] 肺送達のためのベクター、導入剤及び使用2011
- Inventor(s)
  秋田英万、楠本憲司、原島秀吉、畠山浩人、石塚太一
- Industrial Property Rights Holder
  大鵬薬品工業株式会社
- Industrial Property Number
  2011-055765
- Filing Date
  2011-03-14
- Data Source
  KAKENHI-PROJECT-22689002
[Patent] 核移行性を有する脂質膜構造体2011
- Inventor(s)
  原島秀吉、秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2011-04-10
- Overseas
- Data Source
  KAKENHI-PROJECT-22659006
[Patent] 核内移行性を有する脂質膜構造体2011
- Inventor(s)
  原島秀吉, 秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗
- Industrial Property Rights Holder
  原島秀吉,秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗
- Filing Date
  2011-04-20
- Overseas
- Data Source
  KAKENHI-PROJECT-22229001
[Patent] 細胞内動態を改善したカチオン性脂質2011
- Inventor(s)
  丹下耕太、新井将也、久保和弘、秋田英万、原島秀吉、畠山浩人、石破諒平、鵜川真実
- Industrial Property Rights Holder
  丹下耕太、新井将也、久保和弘、秋田英万、原島秀吉、畠山浩人、石破諒平、鵜川真実
- Industrial Property Number
  2011-252309
- Filing Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-22229001
[Patent] 核内移行性を有する脂質膜構造体2011
- Inventor(s)
  原島秀吉,秋田英万、シャリフモハメドシャヒーン、中村孝司、石井聡一郎、二木史朗、権利者
- Filing Date
  2011-04-20
- Overseas
- Data Source
  KAKENHI-PROJECT-22659006
[Patent] 機能性ポリペプチド及び当該ポリペプチドで修飾された脂質膜構造体2010
- Inventor(s)
  原島秀吉, 秋田英万, 畠山浩人, 他
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Number
  2010-039667
- Filing Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-20015003
[Patent] 機能性ポリペプチド及び当該ポリペプチドで修飾された脂質膜構造体2010
- Inventor(s)
  原島秀吉、秋田英万、榎戸薫、畠山浩人、櫻井遊
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2010-039667
- Filing Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-19680025
[Patent] 機能性ポリペプチドお呼び当該ポリペプチドで就職された脂質膜構造体2010
- Inventor(s)
  原島秀吉, 秋田英万、榎戸薫、畠山浩人、桜井遊
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-20015003
[Patent] 脂質膜構造体に細胞透過能を付与するペプチドと結合した脂質を構成脂質として含む、細胞透過能を有する脂質膜構造体.2009
- Inventor(s)
  原島秀吉, 秋田英万、藤原孝博
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2009-12-14
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] 脂質膜構造体に細胞透過能を付与するペプチド、およびそれらペプチドと結合した脂質を構成脂質として含む、細胞透過能を有する脂質膜構造体2009
- Inventor(s)
  秋田英万、藤原孝博、原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2009-283091
- Filing Date
  2009-12-14
- Data Source
  KAKENHI-PROJECT-20650072
[Patent] 脂質膜構造体に細胞透過能を付与するペプチド、およびそれらペプチドと結合した脂質を構成脂質として含む、細胞透過能を有する脂質膜構造体2009
- Inventor(s)
  秋田英万、藤原孝博、原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2009-283091
- Filing Date
  2009-12-14
- Data Source
  KAKENHI-PROJECT-19680025
[Patent] 脂質膜構造体2009
- Inventor(s)
  原島秀吉, 秋田英万、アイマンエルサイド、増田智也
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-20659020
[Patent] 核輸送性脂質膜構造体2009
- Inventor(s)
  原島秀吉, 秋田英万, 増田智也, 新倉謙一, 西尾崇, 居城邦治
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2009-069438
- Filing Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-19680025
[Patent] 生体内で機能する核輸送性脂質膜構造体2009
- Inventor(s)
  秋田英万、増田智也、西尾崇、新倉謙一、居城邦治、原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2009-069438
- Filing Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-19680025
[Patent] 高分子化合物またはその複合体の細胞透過性評価装置およびその細胞透過性評価方法2009
- Inventor(s)
  秋田英万、藤原孝博、田畑泰彦、原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2009-275877
- Filing Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20650072
[Patent] 脂質膜構造体2009
- Inventor(s)
  原島秀吉, 秋田英万、アイマンエルサイド、増田智也
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-20015003
[Patent] 高分子化合物またはその複合体の細胞透過性評価装置およびその細胞透過性評価方法2009
- Inventor(s)
  秋田英万、藤原孝博、田畑泰彦、原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2009-275877
- Filing Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-19680025
[Patent] 核輸送性脂質膜構造体2009
- Inventor(s)
  原島秀吉, 増田智也、秋田英万、西尾崇、新倉謙一、居城邦治
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-20659020
[Patent] オリゴアルキレングリコール修飾された脂質膜構造体2009
- Inventor(s)
  秋田英万、増田智也、居城邦治、新倉謙一、西尾崇、原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-19680025
[Patent] 高分子化合物またはその複合体の細胞透過性評価装置及びその細胞透過性評価方法.2009
- Inventor(s)
  原島秀吉, 秋田英万、藤原孝博、田畑泰彦
- Industrial Property Rights Holder
  北海道大学、京都大学
- Filing Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] 脂質膜構造体2009
- Inventor(s)
  原島秀吉, 秋田英万、アイマンエルサイド、増田智也
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] オリゴアルキレングリコール修飾された脂質膜構造体2008
- Inventor(s)
  原島秀吉,増田智也、秋田英万、居城邦治、新倉謙一、西尾崇
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2008-04-25
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] リポソーム用生体成分抵抗性増強剤及びこれにより修飾されたリポソーム2008
- Inventor(s)
  小暮健太朗、秋田英万、岩朝亮忠、中村宜夫、二木史朗、原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2008-02-27
- Data Source
  KAKENHI-PROJECT-19680025
[Patent] 腫瘍組織で選択的に分解性を示す血中滞留性素子2008
- Inventor(s)
  秋田英万, 畠山浩人, 原島秀吉
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Filing Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20015003
[Patent] オリゴアルキレングリコール修飾された脂質膜構造体2008
- Inventor(s)
  秋田英万、増田智也、居城邦治、新倉謙一、西尾崇、原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2008-115388
- Filing Date
  2008-04-25
- Data Source
  KAKENHI-PROJECT-19680025
[Patent] 脂質膜構造体2008
- Inventor(s)
  原島秀吉,増田智也、秋田英万、石原一彦、金野智浩
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-18200032
[Patent] 腫瘍選択的分解性を示す血中滞留性素子2007
- Inventor(s)
  秋田英万・畠山浩人・長崎幸夫・大石基・菊池寛・小林英夫・原島秀吉
- Industrial Property Rights Holder
  北海道大学、筑波大学、塩野義製薬株式会社
- Filing Date
  2007-07-25
- Overseas
- Data Source
  KAKENHI-PROJECT-18015004
[Patent] リポソーム用生体成分抵抗性増強剤及びこれにより修飾されたリポソーム2007
- Inventor(s)
  小暮健太朗、秋田英万、岩朝亮忠、中村宜夫、二木史朗、原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2007-085628
- Filing Date
  2007-02-28
- Data Source
  KAKENHI-PROJECT-19680025
[Patent] 目的物質をミトコンドリア内に送達可能な脂質膜構造体2006
- Inventor(s)
  山田勇磨, 秋田英万, 小暮健太朗, 紙谷浩之, 原島秀吉, 菊池寛, 小林英夫
- Industrial Property Rights Holder
  北海道大学, 第一製薬株式会社
- Filing Date
  2006-03-09
- Data Source
  KAKENHI-PROJECT-17659039
[Patent] 目的物質をミトコンドリア内に送達可能な脂質膜構造体.2005
- Inventor(s)
  山田勇磨, 秋田英万, 小暮健太朗, 紙谷浩之, 原島秀吉, 菊池寛, 小林英夫
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2005-066385
- Filing Date
  2005-03-09
- Data Source
  KAKENHI-PROJECT-17659039
[Patent] 細胞に導入した核酸の標的オルガネラにおける局在量を定量する方法2003
- Inventor(s)
  原島秀吉, 秋田英万
- Industrial Property Rights Holder
  科学技術振興機構
- Industrial Property Number
  2003-193038
- Filing Date
  2003
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15300151
[Presentation] RNA/核酸創薬を加速する環境応答性脂質様材料ssPalmの開発2024
- Author(s)
  秋田英万
- Organizer
  第454回CBI学会研究講演会
- Invited
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] Contribution of lipid composition and morphology of lipid nanoparticle to its immunostimulatory properties2024
- Author(s)
  essica Anindita, 田中浩揮、山川拓真、佐藤裕果、石崎弘汰、松本千佳、植田圭祐、東顕二郎、森部久仁一、佐々木香純、米持悦生、櫻井遊、秋田英万
- Organizer
  日本薬剤学会　第38年会
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] 次世代送達技術としてのＬＮＰ製剤：肝臓以外の送達に向けた期待と課題2024
- Author(s)
  秋田英万
- Organizer
  日経バイオテク・プロフェッショナルセミナー:次世代の薬物送達技術を俯瞰する
- Invited
- Data Source
  KAKENHI-PROJECT-23H00542
[Presentation] ビタミンE足場型pH応答性脂質様材料を用いたRNAワクチンによる細胞性免疫の活性化2024
- Author(s)
  大山遼太朗、石亀晴道、田中浩揮、西川義文、岡田峰陽、秋田英万
- Organizer
  第22回遺伝子・デリバリー研究会シンポジウム
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] 次世代送達技術としてのＬＮＰ製剤：肝臓以外の送達に向けた期待と課題2024
- Author(s)
  秋田英万
- Organizer
  日経バイオテク・プロフェッショナルセミナー:次世代の薬物送達技術を俯瞰する
- Invited
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] Lipid composition and morphology of lipid nanoparticle contributed to its immuostimulatory properties2024
- Author(s)
  Jessica Anindita, 田中浩揮、植田圭祐、東顕二郎、森部久仁一、佐々木香純、米持悦生、櫻井遊、秋田英万
- Organizer
  日本DDS学会　第39年会
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] RNA創薬を加速するLNP技術2024
- Author(s)
  秋田英万
- Organizer
  医療産業イノベーションフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-23H00542
[Presentation] RNA創薬を加速する環境応答性脂質様材料（ssPalm）2024
- Author(s)
  秋田　英万
- Organizer
  第45回日本バイオマテリアル学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] RNA創薬を加速する環境応答性脂質様材料(ssPalm)2024
- Author(s)
  秋田英万
- Organizer
  Nano Tech2024
- Invited
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] RNA創薬を加速するLNP技術2024
- Author(s)
  秋田英万
- Organizer
  医療産業イノベーションフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] 2本鎖アンチセンスオリゴ核酸内封 Ready-to-Use型脂質ナノ粒子の開発2024
- Author(s)
  松本千佳、田中浩揮、佐藤裕果、中井悠太、丹下耕太、櫻井遊、秋田英万
- Organizer
  第44回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] RNA/核酸創薬を加速する環境応答性脂質様材料ssPalmの開発2024
- Author(s)
  秋田英万
- Organizer
  第454回CBI学会研究講演会
- Invited
- Data Source
  KAKENHI-PROJECT-23H00542
[Presentation] RNA創薬を加速する環境応答性脂質様材料(ssPalm)2024
- Author(s)
  秋田英万
- Organizer
  Nano Tech2024
- Invited
- Data Source
  KAKENHI-PROJECT-23H00542
[Presentation] 脂質ナノ粒子を用いた血液脳関門を構成する脳毛細血管内皮細胞への核酸送達システムの開発2024
- Author(s)
  渡邉妃香、櫻井遊、西尾一真、橋本耕平、原田純希、大山遼太朗、中井裕太、丹下耕太、田中浩揮、秋田英万
- Organizer
  日本DDS学会　第39年会
- Data Source
  KAKENHI-PROJECT-23H00542
[Presentation] LNPの取り込み機構および物性制御を基盤としたnon-hepatic targeting2024
- Author(s)
  秋田　英万
- Organizer
  日本薬剤学会　第38年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] Development of lipid nanoparticles for the control of in vivo immunity: Application in cancer treatment.2024
- Author(s)
  Hidetaka Akita
- Organizer
  The 82nd Annual Meeting of the Japanese Cancer Association
- Invited
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] リンパ球指向性を有する脂質ナノ粒子の開発2022
- Author(s)
  岩崎光希、櫻井遊、丹下耕太、中井悠太、田中浩揮、秋田英万
- Organizer
  第38回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] アニオン性脂質ナノ粒子による脾臓標的化mRNA送達技術の開発2022
- Author(s)
  堀瑞歩、櫻井遊、五味昌樹、中井悠太、丹下耕太、田中浩揮、秋田英万
- Organizer
  第7回日本核酸医薬学会年会
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] 環境応答性脂質様材料ssPalmを基盤とした核酸・RNAデリバリー2022
- Author(s)
  秋田　英万
- Organizer
  北大学金属材料研究所共同研究ワークショップ/日本バイオマテリアル学会東北ブロック講演会
- Invited
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] Development of intracellular environment-responsive lipid-like material: ssPalm for the acceleration of nucleic acid/RNA-based medication2022
- Author(s)
  Hidetaka Akita
- Organizer
  NIMS WEEK2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] mRNA医薬のDDS技術としてのLNP2022
- Author(s)
  秋田　英万
- Organizer
  日経バイオテク・プロフェッショナルセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] Ready-to-Use型LNP製剤の開発2022
- Author(s)
  田中浩揮、萩原伸哉、山川拓真、白根大貴、高田奈依、櫻井遊、福田翔、福澤薫、米持悦生、玉川晋也、中井悠太、丹下耕太、秋田英万
- Organizer
  第7回日本核酸医薬学会年会
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] Ready-to-Use型mRNA内封脂質ナノ粒子製剤の物性評価2022
- Author(s)
  山川拓真、田中浩揮、萩原伸哉、櫻井遊、佐々木香純、米持悦生、福澤薫、中井悠太、丹下耕太、秋田英万
- Organizer
  遺伝子・デリバリー研究会　第21回シンポジウム・第20回夏季セミナー
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] 一工程で使用可能なmRNA内封脂質ナノ粒子Ready-to-Use液体製剤の開発2022
- Author(s)
  佐藤裕果、田中浩揮、萩原伸哉、山川拓真、櫻井遊、中井悠太、丹下耕太、秋田英万
- Organizer
  第43回生体膜と薬物相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] Development of intracellular environment-responsive lipid-like material: ssPalm towards RNA-based medication2022
- Author(s)
  Hidetaka Akita
- Organizer
  2022 Fall International Convention of PSK
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] mRNA delivery to Secondary Lymphoid Tissues by Lipid Nanoparticles Loading Phosphatidylserine2022
- Author(s)
  Gomi M, Sakurai Y, Tanaka H, Sato M, Miyatake Y, Fujiwara K, Watanabe M, Shuto S, Nakai Y, Tange K, Akita H
- Organizer
  NIMS WEEK2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] Ready-to-Use’ ssPalmE-Phe lipid nanoparticle as a platform for RNA-based cancer vaccine delivery2021
- Author(s)
  Jessica Anindita、田中浩揮、大山遼太郎、萩原伸哉、白根大貴、玉川晋也、中井悠太、丹下耕太、吉岡宏樹、秋田英万
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] Ready-to-Use’-type ssPalmE-Phe lipid nanoparticle as a platform for RNA-based vaccine2021
- Author(s)
  Jessica Anindita、田中浩揮、大山遼太郎、萩原伸哉、白根大貴、玉川晋也、中井悠太、丹下耕太、吉岡宏樹、秋田英万
- Organizer
  日本核酸医薬学会第６回年会
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] 使用者の利便性を限りなく追求したmRNA内封脂質ナノ粒子Ready-to-Use製剤の創生2021
- Author(s)
  萩原伸哉、田中浩揮、白根大貴、山川拓真、櫻井遊、玉川晋也、中井悠太、丹下耕太、秋田英万
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] pH応答性脂質を基盤としたT細胞へのmRNA送達技術の開発2021
- Author(s)
  三山亮、田中浩揮、中井悠太、櫻井遊、玉川晋也、丹下耕太、秋田英万
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] 細胞内環境応答性脂質様材料ssPalmを基盤とするマルチ創剤基盤第29回ＤＤＳカンファレンス2021
- Author(s)
  秋田　英万
- Organizer
  第29回静岡ＤＤＳカンファレンス
- Invited
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] 細胞内環境応答性脂質様材料ssPalmの開発2021
- Author(s)
  秋田　英万
- Organizer
  Chem-Station V
- Invited
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] 細胞内環境に応答する脂質様材料を基盤としたRNA・核酸創剤2021
- Author(s)
  秋田　英万
- Organizer
  薬学会北陸支部会例会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] 使用者の利便性を限りなく追求したmRNA内封脂質ナノ粒子Ready-to-Use製剤の創生2021
- Author(s)
  萩原伸哉、田中浩揮、白根大貴、山川拓真、櫻井遊、玉川晋也、中井悠太、丹下耕太、秋田英万
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] 細胞内環境応答性脂質様材料ssPalmの開発2021
- Author(s)
  秋田　英万
- Organizer
  Chem-Station V
- Invited
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] An intracellular responsive lipid like material (ssPalm) as a nucleic acid delivery platform.2021
- Author(s)
  Akita H
- Organizer
  PACIFICHEM 2021.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] An intracellular responsive lipid like material (ssPalm) as a nucleic acid delivery platform.2021
- Author(s)
  Akita H
- Organizer
  PACIFICHEM 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] 水和の一工程のみで使用可能なmRNA内封脂質ナノ粒子Ready-to-Use製剤の創生2021
- Author(s)
  萩原伸哉、田中浩揮、白根大貴、山川拓真、櫻井遊、玉川晋也、中井悠太、丹下耕太、秋田英万
- Organizer
  日本核酸医薬学会第６回年会
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] Ready-to-Use' ssPalmE-Phe lipid nanoparticle as a platform for RNA-based cancer vaccine delivery2021
- Author(s)
  31.Jessica Anindita、田中浩揮、大山遼太郎、萩原伸哉、白根大貴、玉川晋也、中井悠太、丹下耕太、吉岡宏樹、秋田英万
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-21K18320
[Presentation] 組織間のクロストークを標的とした新規がん治療戦略の提唱2021
- Author(s)
  土井瑞貴、大東昂良、田中浩揮、三浦尚也、櫻井遊、秋田英万
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] 抗腫瘍免疫の正常化を介したRISET療法の作用機序解析と応用展開2021
- Author(s)
  土井瑞貴、大東昂良、田中浩揮、三浦尚也、櫻井遊、秋田英万
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] 抗腫瘍免疫の正常化を目的とした脾臓の炎症環境の改善：RISET療法の提唱2020
- Author(s)
  土井瑞貴、大東昂良、田中浩揮、三浦尚也、櫻井遊、秋田英万
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] エマルション型ナノ粒子製剤における薬物の疎水性が血中動態に及ぼす影響2020
- Author(s)
  土井瑞貴、田中浩揮、櫻井遊、秋田英万
- Organizer
  第36回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] 抗炎症薬搭載ナノ粒子による脾臓を標的とした新規がん治療戦略の開発2020
- Author(s)
  土井　瑞貴、大東　昂良、田中　浩揮、三浦　尚也、櫻井　　遊、秋田　英万
- Organizer
  日本薬剤学会　第35年会
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] 細胞内環境に応答する脂質様材料ssPalmが拓くマルチ創剤基盤～低分子デリバリーからRNA創薬まで～2020
- Author(s)
  秋田　英万
- Organizer
  薬物動態談話会第43年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] ssPalmが拓くRNA創剤基盤2020
- Author(s)
  秋田　英万
- Organizer
  JBA“未来へのバイオ技術”勉強会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] 脾臓に対する抗炎症薬送達(RISET療法)の動態およびメカニズム解析2020
- Author(s)
  4.土井瑞貴、大東昂良、田中浩揮、三浦尚也、櫻井遊、秋田英万
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-19K22948
[Presentation] Lymphatic microsurgeryにおけるリンパ節のドレナージ路の確保2020
- Author(s)
  秋田新介三川信之
- Organizer
  第25回日本形成外科手術手技学会
- Data Source
  KAKENHI-PROJECT-17K11529
[Presentation] 環境応答性脂質様材料を基盤としたmRNA導入技術の開発2020
- Author(s)
  秋田　英万、田中浩揮
- Organizer
  日本薬剤学会　第35年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] 遺伝子・核酸創薬を加速する環境応答性脂質様材料ssPalmの開発2020
- Author(s)
  秋田　英万
- Organizer
  第36回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] 細胞内環境に応答性を示す脂質様材料を基盤としたRNA創剤2020
- Author(s)
  秋田　英万
- Organizer
  量子ナノ医療研究センターシンポジウム「コロナウイルス感染症とナノメディシン」
- Invited
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] 人工mRNAベクターを基盤とするT細胞エンジニアリング技術の開発2020
- Author(s)
  三山　　亮、田中　浩揮、中井　悠太、櫻井　　遊、玉川　晋也、丹下　耕太、秋田　英万
- Organizer
  日本薬剤学会　第35年会
- Data Source
  KAKENHI-PROJECT-20H00657
[Presentation] 抗腫瘍免疫の正常化を目的とした脾臓および腫瘍組織における炎症環境の同時改善：RISET療法の提唱2019
- Author(s)
  土井瑞貴、大東昂良、田中浩揮、三浦尚也、丹下耕太、中井悠太、吉岡宏樹、櫻井遊、秋田英万
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19K22948
[Presentation] RISET-therapy: a strategy for resetting tumor micro environment by the delivery of anti-inflammatory drugs to tumor and spleen2019
- Author(s)
  9.Doi M, Ohto T, Tanaka H, Miura N, Sakurai Y, Tange K, Nakai Y, Yoshioka H, Akita H.
- Organizer
  19th Symposium for Gene, Design and Delivery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22948
[Presentation] How to maximize the effect of surgical treatment of lymphoedema2019
- Author(s)
  Shinsuke Akita, Yoshihisa Yamaji, Nobuyuki Mitsukawa
- Organizer
  第10回国際マイクロサージャリー学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11529
[Presentation] How to maximize the effect of surgical treatment of lymphoedema2019
- Author(s)
  Akita S, Mitsukawa N
- Organizer
  10th Congress of World Society for Reconstructive MIcrosurgery
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11529
[Presentation] Development of DNA/RNA vaccine platform based on the intracellular environment-responsive lipid-like material2018
- Author(s)
  Hidetaka Akita
- Organizer
  第77回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19473
[Presentation] Development of mRNA nanocarriers based on environment- responsive materials for the application to cancer vaccines2018
- Author(s)
  Naho Tateshita, Hidetaka Akita
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K19473
[Presentation] 凍結乾燥ワンポット法を用いたsiRNA搭載ナノ粒子の開発2018
- Author(s)
  白根大貴、田中浩揮、櫻井遊、丹下耕太、中井悠太、吉岡宏樹、秋田英万
- Organizer
  日本薬学会　第139年会
- Data Source
  KAKENHI-PROJECT-17K19473
[Presentation] 還元環境依存的な粒子内分解機構を搭載した自己崩壊型RNA送達システムの開発2018
- Author(s)
  高田奈依、田中浩揮、高橋達成、小西真奈美、中井悠太、丹下耕太、吉岡宏樹、玉川晋也、秋田英万
- Organizer
  日本核酸医薬学会第4回年会
- Data Source
  KAKENHI-PROJECT-17K19473
[Presentation] Development of self-hydrolyzable lipid-like material equipped with environment sensing motifs2018
- Author(s)
  Hiroki Tanaka, Manami Konishi, Nae Takata, Tatunari, Takahashi, Yuta Nakai, Hiroki Yoshioka, Hidetaka Akita
- Organizer
  18th Symposium for Gene, Design and Delivery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19473
[Presentation] 細胞内環境応答性材料ssPalmを基盤とした遺伝子・核酸デリバリーとイムノエンジニアリングへの応用2018
- Author(s)
  秋田英万
- Organizer
  第27回　日本癌転移学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19473
[Presentation] Cytoplasmic delivery of exogenous IVT-mRNA using self-degradable lipid-like material.2018
- Author(s)
  Hiroki Tanaka, Manami Konishi, Nae Takada, Tatsunari Takahashi, Yuta Nakai, Kota Tange, Hiroki Yoshioka, Shinya Tamagawa, Hidetaka Akita
- Organizer
  第20回武田科学振興財団生命科学シンポジウム　RNAネオバイオロジー
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19473
[Presentation] Intracellular environment-responsive material (ssPalm), as a technology for the DNA/RNA-based immune-engineering2018
- Author(s)
  Hidetaka Akita
- Organizer
  THE 12th SUGIYAMA LABORATORY (RIKEN) OPEN SYMPOSIUM
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19473
[Presentation] Cancer-type organic anion transporting polypeptide 1B3 is a promising target for spliceosome-mediated RNA trans-splicing based suicide gene therapy2018
- Author(s)
  Hanae Morio, Yuchen Sun, Manami Harada, Ulrich Koller, Anna Stierschneider, Josefina Pinon Hofbauer, Christina Gruber, Hidetaka Akita, Naohiko Anzai, Kan Chiba, Tomomi Furihata.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19475
[Presentation] 細胞内環境応答性脂質様材料を基盤とするin vivoメッセンジャーRNA送達システムの開発2018
- Author(s)
  小西真奈美、田中浩揮、高橋達也、高田奈依、中井悠太、丹下耕太、吉岡宏樹、玉川晋也、秋田英万
- Organizer
  第12回　次世代を担う若手医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K19473
[Presentation] 凍結乾燥ワンポット法によるsiRNA 搭載型中性脂質ナノ粒子の開発と機能評価2018
- Author(s)
  白根大貴, 田中浩揮, 丹下耕太, 中井悠太, 吉岡宏樹, 秋田英万
- Organizer
  第34回日本ＤＤＳ学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19473
[Presentation] Development of RNA vaccine platform based on an intracellular environment-responsive lipid like material with vitamin E-scaffold2018
- Author(s)
  Jessica Anndita、Naho Tateshita、Hiroki Tanaka、Naoya Miura, Yu Sakurai、Kota Tange 、Yuta Nakai、Hiroki Yoshioka、Hidetaka Akita
- Organizer
  日本薬学会　第139年会
- Data Source
  KAKENHI-PROJECT-17K19473
[Presentation] リンパ浮腫非侵襲評価方法の確立と侵襲的定量評価方法の開発2017
- Author(s)
  秋田新介　山路佳久　窪田吉孝　手塚崇文　笹原資太郎　三川信之
- Organizer
  第44回日本マイクロサージャリー学会
- Data Source
  KAKENHI-PROJECT-17K11529
[Presentation] がん特異的遺伝子産物cancer-type OATP1B3を標的とした分子標的遺伝子治療法開発2017
- Author(s)
  降幡知巳、孫雨晨、原田まなみ、Hofbauer P Josefina, Gruber Christina、秋田英万、安西尚彦
- Organizer
  日本がん分子標的治療学会第1回シーズ・ニーズ(SN)ワークショップ
- Data Source
  KAKENHI-PROJECT-17K19475
[Presentation] がん特異的遺伝子Cancer-type OATP1B3標的型RNA trans-splicing分子によるがん遺伝子治療の基盤構築2017
- Author(s)
  森尾花恵、降幡知巳、孫雨晨、原田まなみ、秋田英万、Ulrich Koller、Anna Stierschneider、Josefina Pion Hofbauer、Christina Gruber、千葉寛、安西尚彦
- Organizer
  第136回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-17K19475
[Presentation] リンパ輸送能の定量評価を目的とした腹部リンパシステム可視化マウスモデルの作成2017
- Author(s)
  山路佳久　秋田新介　三川信之
- Organizer
  第26回日本形成外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17K11529
[Presentation] A novel mouse model for visualized and quantitative assessment of lymphatic function using an in vivo imaging system2017
- Author(s)
  Yoshihisa Yamaji, Shinsuke Akita, Nobuyuki Mitsukawa
- Organizer
  26th World Congress of Lymphology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11529
[Presentation] がん特異的遺伝子Cancer-type OATP1B3を標的としたRNA trans-splicing分子によるがん自殺遺伝子治療の基盤確立2017
- Author(s)
  井手秀行、孫雨晨、原田まなみ、森尾花恵、秋田英万、Ulrich Koller、Anna Stierschneider、Josefina Pion Hofbauer、Christina Gruber、千葉寛、安西尚彦、降幡知巳
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K19475
[Presentation] 効率的な肝臓へのsiRNAデリバリーのためのビタミンＥ骨格、pH応答性並びにジスルフィド結合開裂能を有する脂質様物質の分子チューニング2016
- Author(s)
  秋田　英万
- Organizer
  油脂優秀論文賞受賞講演会
- Place of Presentation
  奈良女子大学
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] Particle formed with ssPalm as a multi-nanoDDS platform2016
- Author(s)
  Hidetaka Akita
- Organizer
  3rd International Conference on Biomaterials Science in Tokyo (ICBS2016)
- Place of Presentation
  東京大学本郷キャンパス
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14934
[Presentation] Particle formed with ssPalm as a multi-nanoDDS platform2016
- Author(s)
  Hidetaka Akita
- Organizer
  3rd International Conference on Biomaterials Science in Tokyo (ICBS2016)
- Place of Presentation
  東京大学本郷キャンパス
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] Particle formed by ssPalm as a nanoDDS platform for the genes and nucleic acids2016
- Author(s)
  Hidetaka Akita
- Organizer
  The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Place of Presentation
  Kyoto
- Year and Date
  2016-06-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] 細胞内環境応答性脂質様材料： ssPalmが拓くマルチ創剤基盤2016
- Author(s)
  秋田　英万
- Organizer
  第1回　黒潮カンファレンス
- Place of Presentation
  サンライズ九十九里
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] 体内・細胞内動態の情報に基づくベクター開発と蛍光技術を用いたナノ粒子物性評価2016
- Author(s)
  秋田　英万
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-15K14934
[Presentation] 細胞内環境応答性脂質様材料を基盤としたマルチ創剤基盤2016
- Author(s)
  秋田　英万
- Organizer
  第31回　日本薬物動態学会
- Place of Presentation
  松本　キッセイ文化ホール
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14934
[Presentation] Particle formed by ssPalm as a multi-nanoDDS platform2016
- Author(s)
  Hidetaka Akita
- Organizer
  HIGOprogram in Kumamoto Univ
- Place of Presentation
  熊本大学
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] 細胞内環境応答性脂質様材料を基盤としたマルチ創剤基盤2016
- Author(s)
  秋田　英万
- Organizer
  第31回　日本薬物動態学会
- Place of Presentation
  松本　キッセイ文化ホール
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] KALA修飾ナノ粒子の蛋白ワクチン技術としての応用2015
- Author(s)
  秋田英万、三浦尚也、中村孝司、原島秀吉
- Organizer
  日本薬剤学会　第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] pH応答性脂質様物質（ssPalm）を用いたナノ粒子構造体の物性評価2015
- Author(s)
  田中浩揮、秋田英万、丹下耕太、中井悠太、原島秀吉
- Organizer
  日本DDS学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] Functionalized Self-Nanoemulsion formed with SS-cleavable and pH-activated Lipid-like Material via Oil-to-Surfactant Transition2015
- Author(s)
  Hiroki Tanaka, Syo Oasa, Masataka Kinjo, Kota Tange, Yuta Nakai, and Hideyoshi Harashima, Hidetaka Akita
- Organizer
  第9回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  千葉大学（千葉県千葉市）
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-15K14934
[Presentation] ssPalmの分子チューニングに基づく肝臓標的型遺伝子・核酸デリバリー技術の開発2015
- Author(s)
  秋田英万
- Organizer
  日本DDS学会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-07-02
- Invited
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] Development of a nanoDDS platform based on an analysis of intracellular trafficking2015
- Author(s)
  秋田　英万
- Organizer
  日本薬物動態学会　第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Invited
- Data Source
  KAKENHI-PROJECT-15K14934
[Presentation] ＫＡＬＡ修飾型脂質ナノ粒子を用いたナノワクチンプラットフォーム2015
- Author(s)
  秋田英万、三浦尚也、シャヒーンモハメド、中村孝司、原島秀吉
- Organizer
  遺伝子・デリバリー研究会　第15回シンポジウム
- Place of Presentation
  京都薬科大学 (京都府京都市）
- Year and Date
  2015-05-01
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] Development of a nanoDDS platform based on an analysis of intracellular trafficking2015
- Author(s)
  Hidetaka Akita
- Organizer
  日本薬物動態学会　第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Invited
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] INVESTIGATION OF OPTIMAL NANOPARTICLE PROPERTIES ON DELIVERY TO THE INFLAMED COLON2015
- Author(s)
  Ayaka Watanabe, Hiroki Tanaka, Tatsuya Ohkawara, Kota Tange, Hiroshi Takeda, Hideyoshi Harashima, Hidetaka Akita
- Organizer
  第9回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  千葉大学（千葉県千葉市）
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] Particle formed by ssPalm as a nanoDDS platform for the genes and nucleic acids2015
- Author(s)
  Hidetaka Akita
- Organizer
  World Drug Delivery Summit 2015
- Place of Presentation
  Houston (USA)
- Year and Date
  2015-08-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] INVESTIGATION OF OPTIMAL NANOPARTICLE PROPERTIES ON DELIVERY TO THE INFLAMED COLON2015
- Author(s)
  Ayaka Watanabe, Hiroki Tanaka, Tatsuya Ohkawara, Kota Tange, Hiroshi Takeda, Hideyoshi Harashima, Hidetaka Akita
- Organizer
  第9回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  千葉大学（千葉県千葉市）
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-15K14934
[Presentation] Keynote Lecture: Development of non-viral nanoDDS for DNA: Analysis, control of the intracellular trafficking and beyond…2015
- Author(s)
  Hidetaka Akita
- Organizer
  World Drug Delivery Summit 2015
- Place of Presentation
  Houston (USA)
- Year and Date
  2015-08-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01806
[Presentation] KALA-modified multi-layered nano particles as antigen gene carrier for MHC Class-I mediated antigen presentation in DNA vaccine approach2011
- Author(s)
  Shaheen SM, Akita H, Nakamura T, Takayama S, Futaki S, Yanashita A, Katoono R, Yui N, Harashima H
- Organizer
  38th Annual Meeting & Exposition of the Controlled Release Society (CRS)
- Place of Presentation
  Gaylord National Hotel and Convention Center (U.S.A.)
- Year and Date
  2011-08-02
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] 樹状細胞由来細胞を標的としたDNA遺伝子導入システム～DNAワクチンへの応用へ向けて～2011
- Author(s)
  秋田英万
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都)(招待講演)
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22659006
[Presentation] Particle Tracking for Intracellular Trafficking of Octaarginine-Modified Liposome : Comparative Study with Adenovirus2010
- Author(s)
  Akita H, Enoto K, Masuda T, Tani T, Mizuguchi H, Harashima H
- Organizer
  The 13th Annual Meeting of the American Society of Gene and cell Therapy
- Place of Presentation
  Wachington DC(USA)
- Year and Date
  2010-05-23
- Data Source
  KAKENHI-PROJECT-22689002
[Presentation] 遺伝子核酸医薬のin vivo適応型ナノキャリアーの実現に向けて2010
- Author(s)
  秋田英万
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京薬科大学(招待講演)
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-22689002
[Presentation] 多機能性エンベロープ型ナノ構造体を用いた遺伝子・核酸の細胞内動態制御へのアプローチ2010
- Author(s)
  秋田英万
- Organizer
  BMB2010
- Place of Presentation
  神戸(招待講演)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22689002
[Presentation] Dynamic analysis and control of intracellular trafficking of gene-encapsulating nano-carrier based on a real-time imaging2010
- Author(s)
  秋田英万
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡(招待講演)
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-22689002
[Presentation] 多機能性エンベロープ型ナノ構造体を用いた細胞内動態制御:in vivo適応型ナノキャリアの実現に向けたアプローチ2009
- Author(s)
  秋田英万
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京、後楽園ホテル
- Data Source
  KAKENHI-PROJECT-20650072
[Presentation] Analysis of intracellular trafficking of pDNA and siRNA for a development of non-viral vector2009
- Author(s)
  H. Akita, S. Hama, K. Kogure and H. Harashima
- Organizer
  日本遺伝子治療学会
- Place of Presentation
  札幌医科大学
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-19021003
[Presentation] 多機能性エンベロープ型ナノ構造体を用いた細胞内動態制御:in vivo適応型ナノキャリアの実現に向け2009
- Author(s)
  秋田英万
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19680025
[Presentation] 多機能性エンベロープ型ナノ構造体を用いた遺伝子の核輸送戦略2009
- Author(s)
  秋田英万
- Organizer
  第32回日本分子生物学会年会(ワークショップ)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19680025
[Presentation] 体内動態制御と細胞内動態制御による低毒性ddsキャリア構築へのアプローチ2009
- Author(s)
  秋田英万
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19680025
[Presentation] 多機能性エンベロープ型ナノ構造体を用いた遺伝子の核輸送戦略2009
- Author(s)
  秋田英万
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜, パシフィコ横浜
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-19680025
[Presentation] Novel approach for the nuclear delivery of DNA via step-wise membrane fusion2008
- Author(s)
  H. Akita, A. Kudo, A. Minoura, K. Kog ure and H. Harashima
- Organizer
  11th Liposome Research Days Conference
- Place of Presentation
  横浜
- Year and Date
  2008-07-20
- Data Source
  KAKENHI-PROJECT-19680025
[Presentation] 細胞内動態解析に基づいた遺伝子キャリア開発へのアプローチ2007
- Author(s)
  秋田英万.原島秀吉
- Organizer
  生体機能シンポジウム若手フォーラム
- Place of Presentation
  仙台(東北大学)
- Year and Date
  2007-09-30
- Data Source
  KAKENHI-PROJECT-19021003
[Presentation] 血管内皮細胞標的化ペプチド搭載リポソームの細胞内取り込み機構の解析2007
- Author(s)
  秋田英万、ディッキー・ムダキュル、タン・エルダル、原島秀吉
- Organizer
  日本薬剤学会第22年会
- Place of Presentation
  大宮(大宮ソニックシティ)
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] 血管内皮標的化ペプチド搭載リポソームの細胞内取り込み機構の解析2007
- Author(s)
  秋田英万、ディッキームダキュル、タンエルダル、原島秀吉
- Organizer
  日本薬剤学会第22年会
- Place of Presentation
  埼玉(大宮)大宮ソニックシティ
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-19680025
[Presentation] Cellular uptake mechanism and intracellular trafficking study of the novel C152-peptide-modified liposomes(C152-Lip)2007
- Author(s)
  ディッキームダキュル、秋田英万、タンエルダル、原島秀吉
- Organizer
  第23回日本DDS学会
- Place of Presentation
  熊本(熊本日航ホテル)
- Year and Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-18200032
[Presentation] 遺伝子デリバリーシステムの開発における細胞内動態の定量評価の意義:トランスレーショナルリサーチにおける新しい視点2007
- Author(s)
  秋田英万
- Organizer
  創剤フォーラム第13回若手研究会
- Place of Presentation
  大阪
- Year and Date
  2007-12-08
- Data Source
  KAKENHI-PROJECT-19680025

1. HARASHIMA Hideyoshi (00183567)

# of Collaborated Projects: 8 results

# of Collaborated Products: 30 results
2. KAMIYA Hiroyuki (10204629)

# of Collaborated Projects: 8 results

# of Collaborated Products: 6 results
3. YAMADA Yuma (60451431)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
4. 小暮健太朗 (70262540)

# of Collaborated Projects: 6 results

# of Collaborated Products: 7 results
5. BABA Yoshinobu (30183916)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. HYODO Mamoru (30548186)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 櫻井遊 (00707234)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
8. KAJIMOTO Kazuaki (10416216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. HAYASHI Yasuhiro (30548178)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. Nishimura Masaharu (00208224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Akita Shinsuke (00436403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
12. Furihata Tomomi (80401008)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. 中谷明弘 (60301149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 谷知己 (80332378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 南川典昭 (40209820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 畠山浩人 (70504786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. 中村孝司 (20604458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. 篠原康雄 (60226157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 渡慶次学 (60311437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 松尾保孝 (90374652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 鈴木雅 (10374290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 三川信之 (40595196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
23. 山口匡 (40334172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 田中浩揮 (60801743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
25. 松下博和 (80597782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 内田康雄 (70583590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KIMURA Hiroki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. SANTIWARANGKOOL Sarochin

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. Kaneda Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. OHKAWARA Tatsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. TAKEDA Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. HIGASHI Kenjirou

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 井上貴雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 森部久仁一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 植田圭祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 西川義文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 渡邉瑞貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akita HIdetaka 秋田 英万

Akita Hidetaka 秋田 英万

AKITA Hidetaka 秋田 英万

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Innovation of On-demand DDS platform of RNA therapeutics based on endothelial ATLASPrincipal Investigator

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Ready-tp-Use RNA-drug discovery for the acceleration of personalized cancer vaccinePrincipal Investigator

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Development of self-assembly prodrug: Application to the cancer therapy by reset of immune-cyclePrincipal Investigator

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Development of nanoDDS for cancer therapy without anti-cancer drug: Proposal of RISET therapy and its therapeutic functionPrincipal Investigator

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Development of the nanoDDS platform for the penetrarion or intracellular delivery: Develioment of the rapid ligand-identification system and in vivo control of intracellular traffickingPrincipal Investigator

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Debelopment of nano satelite-organized archetecture as a technology to control an intracellular traffickingPrincipal Investigator

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Innovation of multi-Drug delivery platform based on the ssPalm: Immune-engineering and cancer therapyPrincipal Investigator

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肺血管標的及び透過型DDSを目的としたナノ粒子のインビボ細胞内動態制御法の確立Principal Investigator

Principal Investigator

Akita HIdetaka 秋田英万

Akita Hidetaka 秋田英万

AKITA Hidetaka 秋田英万