Begum Nasim Ara ＢｅｇｕｍＮａｓｉｍＡｒａ

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Begum Nasim Begum NasimAra

BEGUM Nasim Ara ベーガムナシムアラ

BEGUM NasimAra BEGUM NasimAra

BEGUM Nasim ベガムナシム

ベガムナシムベガムナシム

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Researcher Number	80362507
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定准教授
Affiliation (based on the past Project Information) *help	2015 – 2025: 京都大学, 医学研究科, 特定准教授 2012 – 2014: 京都大学, 医学(系)研究科(研究院), 准教授 2009: 京都大学, 医学研究科, 准教授 2007: 京都大学, 医学研究科, 助教 2006: 京都大学, 医学研究科, COE助手
Review Section/Research Field	Principal Investigator Basic Section 43010:Molecular biology-related / Medical genome science / General medical chemistry Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Biological Sciences
Keywords	Principal Investigator CSR / AID / Genomic Instability / SHM / LSR / Ig / B cell / B Cells / R-loop / MED12 … More / NHEJ / DNA Repair / HNRNPU / Chromatin regulator / Translocation / Serbp1 / hnRNP / BiFC / Brd2 / Samhd1 / Phf5a / hnRNPL / hnRNPK / Recombination / Genomic instability / TOP1 / UNG / BRD4 / SPT6 / FACT / H3K4me3 … More Except Principal Investigator RNA編集 / 抗体遺伝子組換え / 体細胞突然変異 / ヒストン修飾制御 / 活性化誘導性シチジンデアミナーゼ (AID) / DNAシナプス / R-ループ / hnRNP U / hnRNP K / 液一液相分離 / 液ー液相分離 / エンハンサー由来RNA / 遺伝子組換え / トポイソメラーゼ　１ / トポイソメラーゼ１ / トポイソメラーゼ 1 / 免疫グロブリン遺伝子 / AID / FACT複合体 / 大規模シークエンス / 免疫帰国 / 獲得免疫 / 組換え / DNA切断 / DNA修復 / クラススイッチ組換え / 癌 / ゲノム / 抗体 / 免役学 / マイクロアレイ法 / 免疫沈降法 / ウラシルDNAグリコシラーゼ / クラススイッチ Less

Mechanism and Implication of Synaptosome Formation in Ig Gene Recombination and Genomic Stability
- Principal Investigator
  
  本庶佑
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto University
Role of Enhancer RNA in Switch, Suicide, and Oncogenic Recombination in B cellsPrincipal Investigator
- Principal Investigator
  
  Begum NasimAra
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Kyoto University
Molecular mechanism of the AID-recombinosome formation which is essential for vaccine-induced antibody gene diversification
- Principal Investigator
  
  本庶佑
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto University
ole of R-loop in antibody class switching and B cell lymphomagenesisPrincipal Investigator
- Principal Investigator
  
  Begum Nasim
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Kyoto University
Analysis of the molecular mechanism of IgH gene diversification depending on RNA-editing by AID
- Principal Investigator
  
  HONJO TASUKU
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kyoto University
Mechanism of targeted DNA cleavage and recombination by AIDPrincipal Investigator
- Principal Investigator
  
  Begum Nasim
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical genome science
- Research Institution
  Kyoto University
Transcription coupled chromatin regulation in AID induced genome rearrangementPrincipal Investigator
- Principal Investigator
  
  BEGUM NasimAra
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Mechanism for genome instability by activation induced cytidine deaminase induced-reduction of topoisomerase1
- Principal Investigator
  
  HONJO Tasuku
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
AID-dependent genetic alteration mechanism to generate antigen-specific antibodies
- Principal Investigator
  
  HONJO Tasuku
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University

[Book] Molecular Biology of B Cells. Chapter18 (Molecular mechanism of AID function)2015
- Author(s)
  Begum NA Nagaoka H, Kobayashi M and Honjo T
- Publisher
  ESLVIER, Academic Press
- Data Source
  KAKENHI-PROJECT-24590352
[Book] Mol2014
- Author(s)
  Begum Nasim Ara
- Publisher
  Nol.
- Data Source
  KAKENHI-PROJECT-24590352
[Book] Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. Vol.942007
- Author(s)
  Muramatsu, M., Nagaoka, H., Shinkura, R., Begum, N.A., Honjo, T.
- Publisher
  ELSEVIER, Adv. Immunol.
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL2024
- Author(s)
  Santosh K. Gothwal , Ahmed M. Refaat, Mikiyo Nakata, Andre Stanlie, Tasuku Honjo and Nasim A. Begum
- Journal Title
  
  Nucleic Acids Research
  
  Volume: -- Issue: 8 Pages: 1-8
- DOI
  10.1093/nar/gkae204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H00449
[Journal Article] HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression2023
- Author(s)
  Refaat AM, Nakata M, Husain A, Kosako H, Honjo T, Begum NA
- Journal Title
  
  Cell Reports 2023;42(3):112284
  
  Volume: 42(3) Issue: 3 Pages: 1-25
- DOI
  10.1016/j.celrep.2023.112284
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06015, KAKENHI-PROJECT-22H00449
[Journal Article] XLID syndrome gene Med12 promotes Ig isotype switching through chromatin modification and enhancer RNA regulation.2022
- Author(s)
  Haque, F., Honjo, T. and Begum, N. A.
- Journal Title
  
  Science Advances
  
  Volume: 8(47):eadd1466 Issue: 47 Pages: 1-18
- DOI
  10.1126/sciadv.add1466
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06015, KAKENHI-PROJECT-22H00449
[Journal Article] Phf5a regulates DNA repair in class switchrecombination via p400 and histone H2Avariant deposition2021
- Author(s)
  Nasim A Begum, Farazul Haque, Andre Stanlie, Afzal Husain, Samiran Mondal, Mikiyo Nakata, Takako Taniguchi, Hisaaki Taniguchi, Tasuku Honjo
- Journal Title
  
  EMBO J
  
  Volume: e106393 Issue: 12 Pages: 1-21
- DOI
  10.15252/embj.2020106393
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01027, KAKENHI-PROJECT-21K06015
[Journal Article] SAMHD 1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination2020
- Author(s)
  Husain Afzal、Xu Jianliang、Fujii Hodaka、Nakata Mikiyo、Kobayashi Maki、Wang Ji‐Yang、Rehwinkel Jan、Honjo Tasuku、Begum Nasim A
- Journal Title
  
  The EMBO Journal
  
  Volume: 39 Issue: 15
- DOI
  10.15252/embj.2019102931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07547, KAKENHI-PROJECT-19H01027, KAKENHI-PROJECT-19K06485
[Journal Article] Antibody class switch recombination requires SAMHD1-mediated dNTP degradation to promote DNA repair2020
- Author(s)
  Afzal Husain, Jiangling Xu, Hodaka Fuji, Mikiyo Nakata, Kobayashi Maki, Ji- Yang Wang, Jan Rehwinkel, Tasuku Honjo, Nasim A. Begum
- Journal Title
  
  EMBO J.
  
  Volume: under revision
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01027
[Journal Article] RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase2020
- Author(s)
  Ziwei Yin, iMaki Kobayashi, Wenjun Hu, Koichi Higashi, Nasim A Begum, Ken Kurokawa, Tasuku Honjo
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: in press Issue: 21 Pages: 11624-11635
- DOI
  10.1073/pnas.1921115117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06485, KAKENHI-PROJECT-19H01027, KAKENHI-PROJECT-16H06279
[Journal Article] Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination.2017
- Author(s)
  Al Ismail, A., Husain, A., Kobayashi, M., Honjo, T., Begum, N. A.
- Journal Title
  
  International Immunology
  
  Volume: 29 Issue: 11 Pages: 525-537
- DOI
  10.1093/intimm/dxx061
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07214, KAKENHI-PROJECT-15H05784, KAKENHI-PROJECT-16K07251
[Journal Article] Functional requirements of AID's higher-order structure and interaction with RNA-binding proteins.2016
- Author(s)
  Mondal, S., Begum, N. A., Hu, W. and Honjo, T.
- Journal Title
  
  Proc. Nat1. Acad. Sci. USA
  
  Volume: early edition Issue: 11 Pages: 1545-1554
- DOI
  10.1073/pnas.1601678113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22000015, KAKENHI-PROJECT-15H05784, KAKENHI-PROJECT-16K07214
[Journal Article] Chromatin remodeler SMARCA4 recruits topoisomerase 1 and suppresses transcription associated genomic instability2016
- Author(s)
  Afzal Husain, Nasim A. Begum, Takako Taniguchi, Hisaaki Taniguchi, Maki Kobayashi, and Tasuku Honjo.
- Journal Title
  
  Nat. Commu.
  
  Volume: 7 Issue: 1 Pages: 00-00
- DOI
  10.1038/ncomms10549
- NAID
  120006535056
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440007, KAKENHI-PROJECT-22000015, KAKENHI-PROJECT-16K07214
[Journal Article] Identification of DNA cleavage- and recombination-specific hnRNP co-factors for Activation-induced cytidine deaminase.2015
- Author(s)
  Hu W, Begum NA, Mondal S, Stanlie A and Honjo T
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: in press Issue: 18 Pages: 5791-5796
- DOI
  10.1073/pnas.1506167112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590352, KAKENHI-PROJECT-22000015, KAKENHI-PROJECT-15H05784
[Journal Article] Identification of DNA cleavage- and recombination-specific hnRNP co-factors for Activation-induced cytidine deaminase.2015
- Author(s)
  Hu, W., Begum, N. A., Mondal, S., Stanlie, A. and Honjo, T.
- Journal Title
  
  Proc. Nat1. Acad. Sci. USA
  
  Volume: 112 Pages: 5791-5796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22000015
[Journal Article] C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion.2014
- Author(s)
  Sabouri S, Kobayashi M, Begum NA, Xu J, Hirota K, Honjo T
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111 Issue: 6 Pages: 2253-2258
- DOI
  10.1073/pnas.1324057111
- NAID
  120005395696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PUBLICLY-24114509, KAKENHI-PROJECT-24590352, KAKENHI-PROJECT-25281021, KAKENHI-PROJECT-25440007, KAKENHI-PROJECT-22000015
[Journal Article] Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining2014
- Author(s)
  Stanlie A, Yousif AS, Akiyama H, Honjo T and Begum NA.
- Journal Title
  
  Molecular Cell
  
  Volume: 55(1) Issue: 1 Pages: 97-110
- DOI
  10.1016/j.molcel.2014.05.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590352, KAKENHI-PROJECT-22000015
[Journal Article] Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination.2014
- Author(s)
  Yousif AS, Stanlie A, Begum NA and Honjo T
- Journal Title
  
  International Immunology
  
  Volume: 26(10) Issue: 10 Pages: 575-578
- DOI
  10.1093/intimm/dxu071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590352, KAKENHI-PROJECT-22000015
[Journal Article] Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase2014
- Author(s)
  Yousif AS, Stanlie A, Mondal S, Honjo T, Begum NA.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 111 Issue: 11
- DOI
  10.1073/pnas.1402391111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590352, KAKENHI-PROJECT-22000015
[Journal Article] Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation2013
- Author(s)
  Aida M, Hamad N, Stanlie A, Begum NA, Honjo T.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 110 Issue: 19 Pages: 7784-9
- DOI
  10.1073/pnas.1305859110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590352, KAKENHI-PROJECT-22000015
[Journal Article] The histone chaperone SPT6 is required for Activation-induced Cytidine Deaminase target determination through H3K4me3 regulation.2013
- Author(s)
  Begum, N.A. et al.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 32415-32429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000015
[Journal Article] Evolutionary comparison of the mechanism of DNA cleavage with respect to immune diversity and genomic instability.2012
- Author(s)
  Begum NA
- Journal Title
  
  Biochemistry
  
  Volume: 51 Pages: 5243-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590352
[Journal Article] The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation.2012
- Author(s)
  Begum NA
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Issue: 39 Pages: 32415-29
- DOI
  10.1074/jbc.m112.351569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590352
[Journal Article] Evolutionary comparison of the mechanism of DNA cleavage with respect to immune diversity and genomic instability.2012
- Author(s)
  Begum, N.A. and Honjo, T.
- Journal Title
  
  Biochemistry
  
  Volume: 51 Pages: 5243-5256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22000015
[Journal Article] B cell-specific and stimulation-responsive enhancers derepress the Aicda gene by overcoming the effects of silencers.2010
- Author(s)
  Tran, T., Nakata, M., Suzuki, K., Begum, N.A., Shinkura, R., Fagarasan, S., Honjo, T., Nagaoka, H.
- Journal Title
  
  Nature Immunol. 11
  
  Pages: 148-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobilin genes.2009
- Author(s)
  Sabouri, Z., Okazaki, I., Shinkura, R., Begum, N.A., Nagaoka, H., Tsuchimoto, D., Nakabeppu, Y., Honjo, T.
- Journal Title
  
  Int.Immunol. 21
  
  Pages: 947-955
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.2009
- Author(s)
  Kobayashi, M., Aida, M., Nagaoka, H., Begum, N.A., Kitawaki, Y., Nakata, M., Stanlie, A., Doi, T., Kato, L., Okazaki, I., Shinkura R., Muramatsu, M., Kinoshita, K., Honjo, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 22375-22380
- NAID
  120001749564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Further evidence for involvement of a non-canonical function of uracil DNA glycosylase in class switch recombination.2009
- Author(s)
  Begum, N.A., et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 2752-2757
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Further evidence for involvement of a non-canonical function of uracil DNA glycosylase in class switch recombination.2009
- Author(s)
  Begum, N.A., Stanlie, A., Doi, T., Sasaki, Y., Jin, H.W., Kim, Y.S., Nagaoka, H., Honjo, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 2752-2757
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.2007
- Author(s)
  Begum, N.A., Izumi, N., Nishikori, M., Nagaoka, H., Shinkura, R., Honjo, T.
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 731-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.2007
- Author(s)
  Begum, A.N.et al.
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 731-742
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Discovery of activation-induced cytidine deaminase, the engraver of antibody memory.2007
- Author(s)
  Muramatsu, M., Nagaoka, H., Shinkura, R., Begum, N.A., Honjo, T.
- Journal Title
  
  Adv.Immunol. 94
  
  Pages: 1-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.2007
- Author(s)
  Begum, N.A., et al.
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 731-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Presentation] HNRNPU Facilitates Antibody Class Switch Recombination through C-NHEJ Promotion and R-loop suppression2022
- Author(s)
  Ahmed M. Refaat, Nasim A. Begum, Afzal Husain, Mikiyo Nakata, Hidetaka Kosako and Tasuku Honjo
- Organizer
  The 45th Annual Meeting of the Molecular Biology Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06015
[Presentation] HNRNPU Promotes Antibody Class Switch Recombination through C-NHEJ Promotion and R-loop suppression2022
- Author(s)
  Ahmed M. Refaat, Nasim A. Begum, Afzal Husain, Mikiyo Nakata, Hidetaka Kosako and Tasuku Honjo
- Organizer
  The 51st Annual Meeting of The Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06015
[Presentation] The Role of Mediator in Class Switch Recombination2022
- Author(s)
  Farazul Haque, Tasuku Honjo, Nasim A. Begum
- Organizer
  Antibody Diversification and DNA deaminases in Immunity and Cancer
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06015
[Presentation] Function of Sμ-germline transcripts in activation-induced cytidine deaminase (AID)-induced DNA breaks2018
- Author(s)
  Maki Kobayashi, Misao Takemoto, Nasim A. Begum and Tasuku Honjo
- Organizer
  The Keystone Symposia meeting on B Cells: Mechanisms in Immunity and Autoimmunity, Germany
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07214
[Presentation] hnRNP KのRNA結合モチーフはAIDによる免疫グロブリン遺伝子多様化に必須である2018
- Author(s)
  Ziwei Yin, Maki Kobayashi, Wenjun Hu, Nasim A. Begum, Tasuku Honjo
- Organizer
  The 41st Annual Meeting of the Molecular Biology Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07214
[Presentation] Histone Acetyl Reader BRD2 promotes AID induced Genomic Instability2018
- Author(s)
  Santosh Kumar Gothwal, Nasim A. Begum and Tasuku Honjo
- Organizer
  The 2nd International Symposium on Radiation Therapeutics and Biology, Kyoto University
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07214
[Presentation] RNA-binding motifs of AID cofactor hnRNP K are necessary for inducing DNA breaks in IgH locus2018
- Author(s)
  Ziwei Yin, Maki Kobayashi, Wenjun Hu, Nasim A. Begum, Tasuku Honjo
- Organizer
  The Keystone Symposia meeting on B Cells: Mechanisms in Immunity and Autoimmunity, Germany
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07214
[Presentation] Regulation of class switch recombination by bromodomain protein Brd22018
- Author(s)
  Santosh Kumar Gothwal, Nasim A. Begum and Tasuku Honjo
- Organizer
  9th Annual ISAJ Symposium on Interdisciplinary Science & Technology, AIST, Tsukuba
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07214
[Presentation] Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability2017
- Author(s)
  Husain A., Begum, N.A., Taniguchi, T., Taniguchi, H., Kobayashi, M., and Honjo, T.
- Organizer
  International Symposium on Immune Diversity and Cancer Therapy
- Place of Presentation
  Kobe
- Year and Date
  2017-01-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07214
[Presentation] AID's higher order structures and their interaction with RNA- binding proteins2017
- Author(s)
  Monda S, Begum, N.A., and and Honjo, T.
- Organizer
  International Symposium on Immune Diversity and Cancer Therapy
- Place of Presentation
  Kobe
- Year and Date
  2017-01-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07214
[Presentation] Functional requirement of AID's higher order structure2016
- Author(s)
  Mondal S, Begum, N.A., and and Honjo, T.
- Organizer
  Science and Technology Congress
- Place of Presentation
  India
- Year and Date
  2016-11-13
- Data Source
  KAKENHI-PROJECT-16K07214
[Presentation] The Non-Canonical function of UNG in AID induced Antibody Gene Diversification2013
- Author(s)
  Ashraf S. Yousif, Nasim A. Begum and Tasuku Honjo
- Organizer
  15th ICI (International Congress of Immunology). Milan, Italy
- Place of Presentation
  Session B cell development and plasma cell differentiation
- Data Source
  KAKENHI-PROJECT-24590352
[Presentation] Antibody gene diversification by AID requires specialized chromatin regulators2013
- Author(s)
  Nasim A. Begum, Andre Stanlie, Masatoshi Aida and Tasuku Honjo
- Organizer
  World Congress on Advances in Oncology & International Symposium on Molecular Medicine. Crete, Greece.
- Place of Presentation
  Immunology & Molecular Oncology
- Invited
- Data Source
  KAKENHI-PROJECT-24590352
[Presentation] Dynamic Interplay of Transcription Elongation Factors and Histone Modifications in regulating B cells Class Switch Recombination2013
- Author(s)
  Andre Stanlie, Nasim A. Begum and Tasuku Honjo
- Organizer
  SIgN-IFREC Immunology Winter School. Singapore
- Place of Presentation
  Immunology
- Data Source
  KAKENHI-PROJECT-24590352
[Presentation] The Non-Canonical function of UNG plays distinct roles in SHM and CSR2013
- Author(s)
  Ashraf S. Yousif, Nasim A. Begum and Tasuku. Honjo
- Organizer
  42nd JSI Annual Meeting. Chiba, Japan
- Place of Presentation
  Immunoglobulin gene diversification
- Data Source
  KAKENHI-PROJECT-24590352
[Presentation] Chromatin adapter Brd4 serves as a repair platform for immunoglobulin class switch recombination2013
- Author(s)
  Nasim A. Begum, Andre Stanlie, Masatoshi Aida and Tasuku Honjo
- Organizer
  42nd JSI Annual Meeting. Chiba, Japan
- Place of Presentation
  Immunoglobulin gene diversification
- Data Source
  KAKENHI-PROJECT-24590352
[Presentation] Role of Histone Chaperones in AID Induced Antibody Gene Diversification2012
- Author(s)
  Nasim A. Begum
- Organizer
  World DNA and Genome Day (3rd WDD-2012)
- Place of Presentation
  Xi’an, China
- Invited
- Data Source
  KAKENHI-PROJECT-24590352
[Presentation] Distinct role of UNG in antibody class switch recombination and somatic hypermutation2012
- Author(s)
  Nasim A. Begum
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  Awaji, Japan
- Data Source
  KAKENHI-PROJECT-24590352
[Presentation] Chromatin reader Brd4 functions in Ig class switching as a repair complex adaptor of nonhomologous end-joining
- Author(s)
  Andre Stanlie, Ashraf S. Yousif, Honjo Tasuku and Nasim A. Begum
- Organizer
  The 43rd Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Kyoto
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590352
[Presentation] Analysis of Top1-chromatin complex reveals the mechanism of AID induced genomic instability
- Author(s)
  Afzal Husain, Nasim A. Begum, Maki Kobayashi and Tasuku Honjo
- Organizer
  Gordon Research Conference: Genomic Instability-Mechanisms
- Place of Presentation
  Hong Kong
- Year and Date
  2014-07-06 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-24590352
[Presentation] Co-factors of AID function: hnRNP K for DNA cleavage and hnRNP L for recombination
- Author(s)
  Wenjun Hu, Nasim Begum and Tasuku Honjo
- Organizer
  The 43rd Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Kyoto
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590352
[Presentation] Differential regulation of S region hypermutation and class switch recombination by non-canonical functions of uracil DNA glycosylase
- Author(s)
  Ashraf S. Yousif, Andre Stanlie, Samiran Mondal, Honjo Tasuku and Nasim A. Begum
- Organizer
  The 43rd Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Kyoto
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590352

1. HONJO Tasuku (80090504)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
2. KOBAYASHI Maki (20400690)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
3. SHINKURA Reiko (50362471)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAGAOKA Hitoshi (20270647)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. NISHIKORI Momoko (60378635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. CHON Il-Mi (50452339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. DOI Tomomitsu (70437218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 王継揚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 廣田耕志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 新蔵礼子

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results

Begum Nasim Ara Ｂｅｇｕｍ ＮａｓｉｍＡｒａ

Begum Nasim Begum NasimAra

BEGUM Nasim Ara ベーガム ナシム アラ

BEGUM NasimAra BEGUM NasimAra

BEGUM Nasim ベガム ナシム

ベガム ナシム ベガム ナシム

Research Projects

Research Products

Co-Researchers

Mechanism and Implication of Synaptosome Formation in Ig Gene Recombination and Genomic Stability

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Role of Enhancer RNA in Switch, Suicide, and Oncogenic Recombination in B cellsPrincipal Investigator

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Molecular mechanism of the AID-recombinosome formation which is essential for vaccine-induced antibody gene diversification

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ole of R-loop in antibody class switching and B cell lymphomagenesisPrincipal Investigator

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Analysis of the molecular mechanism of IgH gene diversification depending on RNA-editing by AID

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Mechanism of targeted DNA cleavage and recombination by AIDPrincipal Investigator

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Transcription coupled chromatin regulation in AID induced genome rearrangementPrincipal Investigator

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Mechanism for genome instability by activation induced cytidine deaminase induced-reduction of topoisomerase1

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AID-dependent genetic alteration mechanism to generate antigen-specific antibodies

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[Book] Molecular Biology of B Cells. Chapter18 (Molecular mechanism of AID function)2015

Author(s)

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[Book] Mol2014

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[Book] Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. Vol.942007

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[Journal Article] BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL2024

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DOI

Data Source

Begum Nasim Ara ＢｅｇｕｍＮａｓｉｍＡｒａ

BEGUM Nasim Ara ベーガムナシムアラ

BEGUM Nasim ベガムナシム

ベガムナシムベガムナシム