IKENOUE Tsuneo 池上恒雄

Researcher Number	80396712
Other IDs
Affiliation (based on the past Project Information) *help	2021 – 2022: 東京大学, 医科学研究所, 准教授 2010 – 2019: 東京大学, 医科学研究所, 准教授 2012: 東京大学, 医学部附属病院, 助教 2010: 東京大学, 医科学研究所, 準教授
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Digestive surgery / Basic Section 55020:Digestive surgery-related / Tumor biology / Medical genome science
Keywords	Principal Investigator マウスモデル / 肝内胆管癌 / IDH変異 / FBXW7 / 大腸癌 / 遺伝子改変マウス / 大腸腫瘍 / 大腸がん / Notchシグナル / Pten … More / Kras / 起源細胞 / 膵臓癌 / オートファジー / 膵癌 … More Except Principal Investigator マウスモデル / 遺伝子改変マウス / 大腸癌 / バイオマーカー / 大腸癌マウスモデル / 新規分子標的 / 発癌の分子病態 / 治療抵抗性大腸癌 / Wnt / シグナル伝達 / がん / MSI大腸癌マウスモデル / KRAS変異型大腸癌 / TGFbeta / Kras / TGFbetaRII / RAS / ｍTOR阻害剤 / ＭＡＰＫシグナル / mTOR阻害剤 / MEK阻害剤 / PI3Kシグナル / MAPKシグナル / 胆嚢癌 / メチル基転移酵素 / ヒストン / 大腸がん / ゲノム / 疾患関連遺伝子 / 胆道学、膵臓学 / 遺伝子異常 / 薬剤耐性 / 膵癌 / 肝内胆管癌 / 肝臓学 / 細胞内シグナル伝達 / 肝癌 / 胆管癌 / RASGAP / RASシグナル / 消化器癌 / 大腸癌転移マウスモデル / 小腸大腸肛門外科学 Less

IDH変異肝内胆管癌の新規治療標的分子及びパスウェイの同定と治療法開発の基盤構築Principal Investigator
- Principal Investigator
  
  池上恒雄
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Identification of novel driver genes in treatment-resistant colorectal cancer subtypes and development of therapeutic strategies
- Principal Investigator
  
  檜井孝夫
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Hiroshima University
Role of cancer-associated FBXW hotspot mutation in carcinogenesisPrincipal Investigator
- Principal Investigator
  
  Ikenoue Tsuneo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of mechanisms underlying colorectal tumorigenesis associated with deregulation of new Wnt targets
- Principal Investigator
  
  Furukawa Yoichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
Analysis of a novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletionPrincipal Investigator
- Principal Investigator
  
  Ikenoue Tsuneo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Establishment of a novel mouse colon cancer disease model with different genome instability useful for subclass classification
- Principal Investigator
  
  Hinoi Takao
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Department of Clinical Research, National Hospital Organization Kure Medical Center
  Hiroshima University
Molecular targeting therapy against intracellular signaling network in gallbladder cancer
- Principal Investigator
  
  SASAKI Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Functional analysis of a histone methyltransferase in colorectal cancer by comprehensive genome analysis
- Principal Investigator
  
  FURUKAWA Yoichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical genome science
- Research Institution
  The University of Tokyo
Analysis of roles of autophagy in pancreatic cancer using mouse modelsPrincipal Investigator
- Principal Investigator
  
  IKENOUE Tsuneo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Establishment of the novel mouse model of metastatic colorectalcancer and identification of the biomarker for tissue-specific metastasis
- Principal Investigator
  
  HINOI Takao
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Hiroshima University
遺伝子改変マウスを用いた消化器癌発生進展におけるRASAL1の機能解析
- Principal Investigator
  
  杉本貴史
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
The relationship between chronic injury and the origin of the liver tumor analyzed using mouse model
- Principal Investigator
  
  ASAOKA Yoshinari
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
The impact of activated PI3K signal on pancreatic cancer
- Principal Investigator
  
  SASAHIRA Naoki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo

All 2022 2021 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book Other

[Book] BIO Clinica栄養状態センサーであるmTOR経路と癌2012
- Author(s)
  池上恒雄
- Publisher
  北隆社
- Data Source
  KAKENHI-PROJECT-23591011
[Book] BIO Clinica2012
- Author(s)
  池上恒雄
- Publisher
  北隆社
- Data Source
  KAKENHI-PROJECT-23591011
[Book] 肝胆膵2011
- Author(s)
  池上恒雄
- Publisher
  アークメディア
- Data Source
  KAKENHI-PROJECT-23591011
[Book] 実験医学2011
- Author(s)
  池上恒雄
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23591011
[Journal Article] Identification of odontogenic ameloblast associated as a novel target gene of the Wnt/β‐catenin signaling pathway2022
- Author(s)
  Yamaguchi Kiyoshi、Horie Chiaki、Takane Kiyoko、Ikenoue Tsuneo、Nakagawa Saya、Isobe Yumiko、Ota Yasunori、Ushiku Tetsuo、Tanaka Mariko、Fujishiro Jun、Hoshino Noriko、Arisue Atsuhiro、Nishizuka Satoshi、Aikou Susumu、Shida Dai、Furukawa Yoichi
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 3 Pages: 948-960
- DOI
  10.1111/cas.15657
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07563, KAKENHI-PROJECT-21K07975, KAKENHI-PROJECT-20K17641, KAKENHI-PROJECT-22K06976, KAKENHI-PROJECT-22H04923
[Journal Article] Motile sperm domain containing 1 is upregulated by the Wnt/β-catenin signaling pathway in colorectal cancer2022
- Author(s)
  Horie Chiaki、Zhu Chi、Yamaguchi Kiyoshi、Nakagawa Saya、Isobe Yumiko、Takane Kiyoko、Ikenoue Tsuneo、Ohta Yasunori、Tanaka Yukihisa、Aikou Susumu、Tsurita Giichiro、Ahiko Yuka、Shida Dai、Furukawa Yoichi
- Journal Title
  
  Oncology Letters
  
  Volume: 24 Issue: 2 Pages: 282-282
- DOI
  10.3892/ol.2022.13402
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07563, KAKENHI-PROJECT-21K07975, KAKENHI-PROJECT-20K17641
[Journal Article] Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis.2021
- Author(s)
  Liu Xun、Yamaguchi Kiyoshi、Takane Kiyoko、Zhu Chi、Hirata Makoto、Hikiba Yoko、Maeda Shin、Furukawa Yoichi、Ikenoue Tsuneo.
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 9 Pages: 0257090-0257090
- DOI
  10.1371/journal.pone.0257090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03062, KAKENHI-PROJECT-21K07975, KAKENHI-PROJECT-20K17641, KAKENHI-PROJECT-20K07563
[Journal Article] NAFLD exacerbates cholangitis and promotes cholangiocellular carcinoma in mice.2021
- Author(s)
  Maeda S, Hikiba Y, Fujiwara H, Ikenoue T, Sue S, Sugimori M, Matsubayashi M, Kaneko H, Irie K, Sasaki T, Chuma M
- Journal Title
  
  Cancer Sci,
  
  Volume: 12 Issue: 4 Pages: 1471-1480
- DOI
  10.1111/cas.14828
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07899, KAKENHI-PROJECT-21K07975
[Journal Article] Development of an MSI-positive colon tumor with aberrant DNA methylation in a PPAP patient2019
- Author(s)
  Yamaguch K, Shimizu E, Yamaguchi R, Imoto S, Komura M, Hatakeyama S, Noguchi R, Takane K, Ikenoue T, Gohda Y, Yano H, Miyano S, Furukawa Y.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03575
[Journal Article] Development of an MSI-positive colon tumor with aberrant DNA methylation in a PPAP patient2019
- Author(s)
  Yamaguchi K, Shimizu E, Yamaguchi R, Imoto S, Komura M, Hatakeyama S, Noguchi R, Takane K, Ikenoue T, Gohda Y, Yano H, Miyano S, Furukawa Y
- Journal Title
  
  J Hum Genet.
  
  Volume: 64(8) Issue: 8 Pages: 729-740
- DOI
  10.1038/s10038-019-0611-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-17H03575, KAKENHI-PROJECT-17K16530, KAKENHI-PROJECT-17K07214
[Journal Article] Importance of Gastric Cancer for the Diagnosis and Surveillance of Japanese Lynch Syndrome Patients2019
- Author(s)
  Ikenoue T, Arai M, Ishioka C, Iwama T, Kaneko S, Matsubara N, Moriya Y, Nomizu T, Sugano K, Tamura K, Tomita N, Yoshida T, Sugihara K, Naruse H, Yamaguchi K, Nojima M, Nakamura Y, Furukawa Y; Japanese society for cancer of the colon and rectum (JSCCR)
- Journal Title
  
  J Hum Genet.
  
  Volume: 64 Issue: 12 Pages: 1187-1194
- DOI
  10.1038/s10038-019-0674-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07763, KAKENHI-PROJECT-17H03575, KAKENHI-PROJECT-17K07214
[Journal Article] Anti-apoptotic effect by the suppression of IRF1 as a downstream of Wnt/β-catenin signaling in colorectal cancer cells2019
- Author(s)
  Ohsugi T, Yamaguchi K, Zhu C, Ikenoue T, Takane K, Shinozaki M, Tsurita G, Yano H, Furukawa Y.
- Journal Title
  
  Oncogene
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03575
[Journal Article] Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium.2019
- Author(s)
  Kinoshita H, Hayakawa Y, Konishi M, Hata M, Tsuboi M, Hayata Y, Hikiba Y, Ihara S, Nakagawa H, Ikenoue T, Ushiku T, Fukayama M, Hirata Y, Koike K.
- Journal Title
  
  Journal of Pathology
  
  Volume: 247 Issue: 1 Pages: 35-47
- DOI
  10.1002/path.5163
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09369, KAKENHI-PROJECT-17H05081, KAKENHI-PROJECT-16K09279, KAKENHI-PROJECT-17K15927, KAKENHI-PROJECT-17K09346
[Journal Article] Anti-apoptotic effect by the suppression of IRF1 as a downstream of Wnt/β-catenin signaling in colorectal cancer cells2019
- Author(s)
  Ohsugi T, Yamaguchi K, Zhu C, Ikenoue T, Takane K, Shinozaki M, Tsurita G, Yano H, Furukawa Y
- Journal Title
  
  Oncogene
  
  Volume: 38(32) Issue: 32 Pages: 6051-6064
- DOI
  10.1038/s41388-019-0856-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03575, KAKENHI-PROJECT-17K09369, KAKENHI-PROJECT-17K16530, KAKENHI-PROJECT-17K07214
[Journal Article] Efficacy of liquid-based genetic diagnosis of endometrial cancer.2018
- Author(s)
  Matsuura M, Yamaguchi K, Tamate M, Satohisa S, Teramoto M, Iwasaki M, Sugita S, Hasegawa T, Koubo R, Takane K, Ikenoue T, Furukawa Y, Saito T.
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 12 Pages: 4025-4032
- DOI
  10.1111/cas.13819
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16530, KAKENHI-PROJECT-17H03575, KAKENHI-PROJECT-17K07214
[Journal Article] Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation.2018
- Author(s)
  Ikenoue T, Terakado Y, Zhu C, Liu X, Ohsugi T, Matsubara D, Fujii T, Kakuta S,Kubo S, Shibata T, Yamaguchi K, Iwakura Y, Furukawa Y.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 2021-2021
- DOI
  10.1038/s41598-018-19769-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-16K10558, KAKENHI-PROJECT-17K09369, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-26860227, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PUBLICLY-16H01569, KAKENHI-PROJECT-17K07214
[Journal Article] Bidirectional reporter assay using HAL promoter and TOPFLASH improves specificity in high-throughput screening of Wnt inhibitors.2017
- Author(s)
  Yamaguchi K, Zhu C, Ohsugi T, Yamaguchi Y, Ikenoue T, Furukawa Y.
- Journal Title
  
  Biotechnology and Bioengineering
  
  Volume: 114 Issue: 12 Pages: 2868-2882
- DOI
  10.1002/bit.26394
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09369, KAKENHI-PROJECT-17H03575, KAKENHI-PROJECT-17K07214
[Journal Article] Genetic alterations in Japanese extrahepatic biliary tract cancer.2017
- Author(s)
  Noguchi R, Yamaguchi K, Ikenoue T, Terakado Y, Ohta Y, Yamashita N, Kainuma O, Yokoi S, Maru Y, Nagase H, Furukawa Y.
- Journal Title
  
  Oncology Letters
  
  Volume: 14 Issue: 1 Pages: 877-884
- DOI
  10.3892/ol.2017.6224
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09369, KAKENHI-PUBLICLY-16H01569, KAKENHI-PROJECT-17K07214
[Journal Article] FERM domain-containing protein 5 (FRMD5) as a novel target of β-catenin/TCF7L2 complex.2017
- Author(s)
  Zhu C, Yamaguchi K, Osugi T, Terakado Y, Noguchi R, Ikenoue T, Furukawa Y
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中 Issue: 4 Pages: 612-619
- DOI
  10.1111/cas.13174
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01569, KAKENHI-PROJECT-17K09369, KAKENHI-PROJECT-17H03575, KAKENHI-PROJECT-17K07214
[Journal Article] Decreased expression of interferon-induced protein 2 (IFIT2) by Wnt/β-catenin signaling confers anti-apoptotic properties to colorectal cancer cells.2017
- Author(s)
  Ohsugi T, Yamaguchi K, Zhu C, Ikenoue T, Furukawa Y.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 59 Pages: 100176-100186
- DOI
  10.18632/oncotarget.22122
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09369, KAKENHI-PROJECT-17H03575, KAKENHI-PUBLICLY-16H01569, KAKENHI-PROJECT-17K07214
[Journal Article] Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation.2016
- Author(s)
  Miguchi M, Hinoi T, Shimomura M, Adachi T, Saito Y, Niitsu H, Kochi M, Sada H, Sotomaru Y, Ikenoue T, Shigeyasu K, Tanakaya K, Kitadai Y, Sentani K, Oue N, Yasui W, Ohdan H.
- Journal Title
  
  PLoS One
  
  Volume: 11
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293284
[Journal Article] A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion.2016
- Author(s)
  Ikenoue T, Terakado Y, Nakagawa H, Hikiba Y, Fujii T, Matsubara D, Noguchi R, Zhu C, Yamamoto K, Kudo Y, Asaoka Y, Yamaguchi K, Ijichi H, Tateishi K, Fukushima N, Maeda S, Koike K, Furukawa Y
- Journal Title
  
  Sci Rep
  
  Volume: 印刷中 Issue: 1 Pages: 23899-23899
- DOI
  10.1038/srep23899
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860206, KAKENHI-PROJECT-25280105, KAKENHI-PROJECT-25290045, KAKENHI-PROJECT-25460432, KAKENHI-PROJECT-26460425, KAKENHI-PROJECT-26461031, KAKENHI-PROJECT-26462136, KAKENHI-PROJECT-16K15422, KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-16K10558, KAKENHI-PROJECT-26860227, KAKENHI-PROJECT-15H04806
[Journal Article] Characterization of a New Small Bowel Adenocarcinoma Cell Line and Screening of Anti-Cancer Drug against Small Bowel Adenocarcinoma2015
- Author(s)
  Hirobumi Suzuki, Yoshihiro Hirata, Nobumi Suzuki, Sozaburo Ihara, Kosuke Sakitani, Yuka Kobayashi, Hiroto Kinoshita,Yoku Hayakawa, Atsuo Yamada, Hirotsugu Watabe, Keisuke Tateishi, Tsuneo Ikenoue, Yutaka Yamaji, and Kazuhiko Koike
- Journal Title
  
  American Journal of Pathology
  
  Volume: 185 Issue: 2 Pages: 550-562
- DOI
  10.1016/j.ajpath.2014.10.006
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590931, KAKENHI-PROJECT-26461031, KAKENHI-PROJECT-26460962
[Journal Article] Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer2014
- Author(s)
  Yamaguchi K, Yamaguchi R, Takahashi N, Ikenoue T, Fujii T, Shinozaki M, Tsurita G, Hata K, Niida A, Imoto S, Miyano S, Nakamura Y, Furukawa Y
- Journal Title
  
  PLoS ONE
  
  Volume: 9
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer.2014
- Author(s)
  Yamaguchi K, Rui Yamaguchi R, Takahashi N, Ikenoue T, Fujii T, Shinozaki M, Tsurita G, Hata K, Niida A, Imoto S, Miyano S, Nakamura Y, Furukawa Y
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 1 Pages: e85750-e85750
- DOI
  10.1371/journal.pone.0085750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310137, KAKENHI-PROJECT-25280105
[Journal Article] Identification of two Wnt-responsive elements in the intron of RING Finger Protein 43 (RNF43) gene.2014
- Author(s)
  Takahashi N, Yamaguchi K, Ikenoue T, Fujii T, Furukawa Y.
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 1 Pages: e86582-e86582
- DOI
  10.1371/journal.pone.0086582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] Identification of two Wnt-responsive elements in the intron of RING Finger Protein 43 (RNF43) gene2014
- Author(s)
  Takahashi N, Yamaguchi K, Ikenoue T, Fujii T, Furukawa Y
- Journal Title
  
  PLoS ONE
  
  Volume: 9
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals2013
- Author(s)
  Miyabayashi K, Ijichi H, Mohri D, Tada M, Yamamoto K, Asaoka Y, Ikenoue T, Tateishi K, Nakai Y, Isayama H, Morishita Y, Omata M, Mo HL, Koike K.
- Journal Title
  
  Cancer Research
  
  Volume: 73 Pages: 2221-2234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591011
[Journal Article] MRG-binding protein contributes to colorectal cancer development2011
- Author(s)
  Yamaguchi K, Sakai M, Kim J, Tsunesumi S, Fujii T, Ikenoue T, Yamada Y, Akiyama Y, Muto Y, Yamaguchi R, Miyano S, Nakamura Y, Furukawa Y
- Journal Title
  
  Cancer Sci
  
  Volume: 102(8) Pages: 1486-92
- NAID
  10030242078
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] Reduced expression of Ras protein like 1 in gastric cancer2011
- Author(s)
  Seto M, Ikenoue T, et al
- Journal Title
  
  International Journal of Cancer
  
  Volume: 128 Pages: 1293-1302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590678
[Journal Article] MRG-binding protein contributes to colorectal cancer development2011
- Author(s)
  Yamaguchi K, Sakai M, Kim J, Tsunesumi S, Fujii T, Ikenoue T, Yamada Y, Akiyama Y, Muto Y, Yamaguchi R, Miyano S, Nakamura Y, Furukawa Y
- Journal Title
  
  Cancer Science
  
  Volume: 102 Pages: 1486-1492
- NAID
  10030242078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletion.2010
- Author(s)
  Asaoka Y, Tada M, Ikenoue T, Seto M, Imai M, Miyabayashi K, Yamamoto K, Yamamoto S, Kudo Y, Mohri D, Isomura Y, Ijichi H, Tateishi K, Kanai F, Ogawa S, Omata M, Koike K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 394(4) Issue: 4 Pages: 1042-6
- DOI
  10.1016/j.bbrc.2010.03.120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590717
[Presentation] Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis2021
- Author(s)
  Ikenoue T, Liu X, Yamaguchi K, Takane K, Zhu C, Hirata M, Hikiba Y, Maeda S, Furukawa Y
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07975
[Presentation] 大腸癌においてWnt /β-カテニンシグナルはインターフェロン制御因子2019
- Author(s)
  大杉友之, 山口貴世志, 池上恒雄, 高根希世子, 篠崎大, 矢野秀朗, 釣田義一郎, 古川洋一
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03575
[Presentation] 大腸癌においてWnt/beta-カテニンシグナルはインターフェロン制御因子1(IRF1)を制御する2019
- Author(s)
  大杉友之、山口貴世志、池上恒雄、高根希世子、篠崎　大、釣田　義一郎、古川洋一
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09369
[Presentation] ロングリードシーケンスによるリンチ症候群患者のミスマッチ修復遺伝子の構造異常の解析2019
- Author(s)
  山口貴世志, 笠島理加, 清水英悟, 高根希世子, 池上恒雄, 山口類, 井元清哉, 宮野悟, 古川洋一
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03575
[Presentation] Wnt/β-catenin signaling controls interferon regulatory factor 1 (IRF1) in colorectal cancer cells.2019
- Author(s)
  Yamaguchi K, Ohsugi T, Takane K, Ikenoue T, Furukawa Y
- Organizer
  11th AACR-JCA Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03575
[Presentation] Molecular features of colorectal cancer in patient with polymerase proofreading-associated polyposis (PPAP)2018
- Author(s)
  Yamaguchi K, Shimizu E, Hatakeyama S, Noguchi R, Ikenoue T, Yamaguchi R, Imoto S, Miyano S, Furukawa Y
- Organizer
  The Joint Symposium of the 13th International Symposium of the Institute Network for Biomedical Sciences and the 28th Hot Spring Harbor International Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03575
[Presentation] Context-dependent induction of distinct liver tumors in mice with Kras activation and Pten inactivation2018
- Author(s)
  池上恒雄、寺門侑美、劉洵、高根希世子、山口貴世志、古川洋一
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09369
[Presentation] Identification of FERM Domain-Containing Protein 5 (FRMD5) as a Novel Target of β-Catenin/TCF7L2 Complex2017
- Author(s)
  Furukawa Y, Zhu C, Ohsugi T, Terakado Y, Noguchi R, Ikenoue T, Yamaguchi K
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03575
[Presentation] Wnt Signaling Induces Anti-Apoptotic Effect in Colorectal Cancer Cells Through the Suppression of IFIT2017
- Author(s)
  Ohsugi T, Zhu C, Ohsugi T, Terakado Y, Noguchi R, Ikenoue T, Yamaguchi K, Furukawa Y
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03575
[Presentation] Molecular characterization of an intrahepatic cholangiocarcinoma mouse model induced by Kras mutation and Pten deletion2016
- Author(s)
  Tsuneo Ikenoue, Yumi Terakado, Kiyoshi Yamaguchi, Yoichi Furukawa
- Organizer
  AACR Annual Meeting 2016
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461031
[Presentation] Analysis of the role of Notch-Rbpj axis in intrahepatic cholangiocarcinoma2016
- Author(s)
  Yumi Terakado, Tsuneo Ikenoue, Kiyoshi Yamaguchi, Yoichi Furukawa
- Organizer
  AACR Annual Meeting 2016
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461031
[Presentation] Analysis of the cellular origin of intrahepatic cholangiocarcinoma using a novel mouse model2016
- Author(s)
  Yumi Terakado, Tsuneo Ikenoue, Rei Noguchi, Chi Zhu, Daisuke Matsubara, Kiyoshi Yamaguchi, Yoichi Furukawa
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461031
[Presentation] Molecular characterization of an intrahepatic cholangiocarcinoma mouse model induced by Kras mutation and Pten deletion.2015
- Author(s)
  Ikenoue T, Terakado Y, Yamaguchi K, Asaoka Y, , Ijichi H, Tateishi K, Koike K, Furukawa Y.
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2015-10-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461031
[Presentation] Analysis of the role of Notch-Rbpj axis in intrahepatic cholangiocarcinoma2015
- Author(s)
  Terakado Y, Ikenoue T, Yamaguchi K, Asaoka Y, , Ijichi H, Tateishi K, Koike K, Furukawa Y.
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2015-10-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461031
[Presentation] 次世代シークエンサーを用いての日本人胆道がんの包括的遺伝子解析2014
- Author(s)
  野口玲, 山口貴世志, 荒川茉莉子, 大田泰徳, 池上恒雄, 古川洋一
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26461031
[Presentation] 肝特異的Kras活性化及びPten欠失による新規肝内胆管癌マウスモデルの樹立と解析2014
- Author(s)
  寺門侑美、池上恒雄、山口貴世志、浅岡良成、伊地知秀明、立石敬介、小池和彦、古川洋一
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26461031
[Presentation] Idenntification of a single nucleotide polymorphism associated with SIAH2 expression2013
- Author(s)
  Seham Elgazzar 髙橋則彦　山口貴世志　前仏均　片桐豊雅　池上恒雄　中村祐輔　古川洋一
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23310137
[Presentation] オートファジー不全は恒常活性化型Kras変異に起因するマウス膵腫瘍の発生を促進する2013
- Author(s)
  池上恒雄、今井光穂、藤井智明、山口貴世志、松原大祐、伊地知秀明、立石敬介、小池和彦、古川洋一
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23591011
[Presentation] リングフィンガープロテイン43の転写調節機構および下流遺伝子解析2013
- Author(s)
  髙橋則彦　山口貴世志　池上恒雄　古川洋一
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23310137
[Presentation] オートファジー不全はマウス膵腫瘍の発生を促進する2012
- Author(s)
  今井光穂、池上恒雄、藤井智明、磯村好洋、小池和彦、古川洋一
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23591011
[Presentation] 遺伝子改変マウスを用いた膵癌の起源細胞へのアプローチ2012
- Author(s)
  伊地知秀明、宮林弘至、多田素久、浅岡良成、池上恒雄、立石敬介、森下保幸、小俣政男、小池和彦
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23591011
[Presentation] 膵微小環境を標的とした膵癌新規治療の探索2012
- Author(s)
  多田素久、伊地知秀明、宮林弘至、浅岡良成、毛利大、池上恒雄、立石敬介、金井文彦、石原武、今関文夫、モーゼスハロルド、小俣政男、横須賀収
- Place of Presentation
  札幌
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-23591011
[Presentation] Identifying the target of histone methyltransferase SMYD3 in colorectal cancer cells2012
- Author(s)
  山口貴世志、池上恒雄、宮野悟、中村祐輔、古川洋一
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（札幌）
- Data Source
  KAKENHI-PROJECT-23310137
[Presentation] Defective in sister chromatoid cohesion 1 homolog (DSCC1), a novel target of E2F1 is overexpressed in colorectal cancer2011
- Author(s)
  山口貴世志、藤井智明、池上恒雄、中村祐輔、古川洋一
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23310137
[Presentation] 遺伝子改変膵自然発癌マウスモデルを用いた膵癌次世代薬物療法の探索2011
- Author(s)
  多田素久、伊地知秀明、宮林弘至、浅岡良成、毛利大、池上恒雄、立石敬介、石原武、金井文彦、今関文夫、Harold L Moses, 小俣政男、横須賀収
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591011
[Presentation] 膵癌微小環境におけるCXCケモカイン/CXCR2 Axis阻害の重要性2011
- Author(s)
  伊地知秀明、多田素久、宮林弘至、浅岡良成、立石敬介、池上恒雄、小俣政男、小池和彦
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23591011
[Presentation] Decreased expression of Ras protein like 1 in gastric cancer2010
- Author(s)
  Ikenoue T, Seto M, et al
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22590678
[Presentation] オートファジー不全はマウス膵腫瘍の発生を促進する
- Author(s)
  今井光穂、池上恒雄、藤井智明、磯村好洋、小池和彦、古川洋一
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市・ロイトン札幌
- Data Source
  KAKENHI-PROJECT-23591011
[Presentation] 膵微小環境を標的とした膵癌新規治療の探索
- Author(s)
  多田素久、伊地知秀明、宮林弘至、浅岡良成、毛利大、池上恒雄、立石敬介、金井文彦、石原武、今関文夫、モーゼス　ハロルド、小俣政男、横須賀収
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市・札幌市教育文化センター
- Data Source
  KAKENHI-PROJECT-23591011
[Presentation] The generation of colorectal cancer mouse model based on microsatellite instability and the identification of transforming growth factor-beta signal target
- Author(s)
  Masashi Miguchi, Takao Hinoi, Manabu Shimomura, Tomohiro Adachi, Yasufumi Saito, Hiroaki Niitsu, Masatoshi Kochi, Yusuke Sotomaru, Hideaki Ijichi, Tsuneo Ikenoue, Kunitoshi Shigeyasu, Kohji Tanakaya, Kazuhiro Sentani, Naohide Oue, Wataru Yasui, Hideki Ohdan
- Organizer
  AACR 2015
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] 遺伝子改変マウスを用いた膵癌の起源細胞へのアプローチ
- Author(s)
  伊地知秀明、宮林弘至、多田素久、浅岡良成、池上恒雄、立石敬介、森下保幸、小俣政男、小池和彦
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市・札幌市教育文化センター
- Data Source
  KAKENHI-PROJECT-23591011
[Presentation] オートファジー不全は恒常活性化型Kras変異に起因するマウス膵腫瘍の発生を促進する。
- Author(s)
  池上恒雄、今井光穂、藤井智明、山口貴世志、松原大祐、伊地知秀明、立石敬介、小池和彦、古川洋一
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜市・パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23591011
[]
[]
[]
[]
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[]

1. IJICHI Hideaki (70463841)

# of Collaborated Projects: 6 results

# of Collaborated Products: 13 results
2. FURUKAWA Yoichi (20272560)

# of Collaborated Projects: 6 results

# of Collaborated Products: 39 results
3. HINOI Takao (10444689)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SOTOMARU Yusuke (90309352)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. OUE Naohide (60346484)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. ASAOKA Yoshinari (90431858)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. SASAKI Takashi (10569106)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YAMAGUCHI Kiyoshi (50466843)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
9. OKAJIMA Masazumi (90274068)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MIYAMOTO Kazuaki (30332373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SASAHIRA Naoki (30401102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TADA Minoru (80302719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMAGUCHI Rui (90380675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
14. FUJII Tomoaki (10511420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. MOURI Dai (20582513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TOMONAGA Takeshi (80227644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. OHDAN Hideki (10363061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. 杉本貴史 (40534920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 坂本直也 (20571798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 下村学 (60457249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 仙谷和弘 (30508164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 高倉有二 (20581698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ADACHI Tomohiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. SAITO Yasufumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. MIGUCHI Masashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
26. NIITSU Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
27. MAEDA Shin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. CHUMA Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. MATSYBARA Daisuk

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. HINO Takao

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. HIRATA Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. SUZUKI Hirobumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 高根希世子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 平田真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 井元清哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 宮野悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 山田篤生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 富田尚裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 田村和朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IKENOUE Tsuneo 池上 恒雄

Research Projects

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Co-Researchers

IDH変異肝内胆管癌の新規治療標的分子及びパスウェイの同定と治療法開発の基盤構築Principal Investigator

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Role of cancer-associated FBXW hotspot mutation in carcinogenesisPrincipal Investigator

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Analysis of a novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletionPrincipal Investigator

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Analysis of roles of autophagy in pancreatic cancer using mouse modelsPrincipal Investigator

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[Book] BIO Clinica栄養状態センサーであるmTOR経路と癌2012

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[Book] BIO Clinica2012

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IKENOUE Tsuneo 池上恒雄