Ogihara Takuo 荻原琢男

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OGIHARA Takuo 荻原琢男

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Researcher Number	80448886
Other IDs
Affiliation (Current)	2025: 東京理科大学, 薬学部生命創薬科学科, 教授
Affiliation (based on the past Project Information) *help	2025: 東京理科大学, 薬学部生命創薬科学科, 教授 2010 – 2023: 高崎健康福祉大学, 薬学部, 教授 2007 – 2008: 高崎健康福祉大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy / Applied pharmacology Except Principal Investigator Applied pharmacology / Basic Section 47060:Clinical pharmacy-related / Eating habits / Medical pharmacy
Keywords	Principal Investigator P-糖タンパク / 排出系トランスポーター / 足場タンパク / BCRP / P-gp / トランスポーター / 多剤耐性 / radixin / がん多剤耐性 / 自殺企図 … More / 自殺 / 血液脳関門 / テストステロン / 一塩基多型 / P-糖タンパク質 / SNPs / antipsychotic drug / suicide / Testosterone / Blood-Brain Barrier / DEI / P-Glycoprotein / 浸潤と転移 / 薬剤耐性 / エンチノスタット / 肺がん / 薬物耐性 / EMT / HepG2細胞 / HCC827細胞 / MRP5 / 足場タンパクERM / 免疫沈降法 / Snail / mRNA / ERMタンパク質 / 転写調節因子 / 上皮間葉転換 / 組織差 / 消化管がん / 腎臓がん / MRP / P-糖たんぱく / MRPs / がん組織 / 網羅的な阻害 / MRPｓ / 脳保護作用 / シルニジピン / 脳組織移行性 / 消化管吸収 / ラディキシン / 輸送活性 / 正常組織 / がん細胞 / 排出組織 / 組織選択性 / ＥＲＭタンパク / 調節因子 / 膜上発現 / 裏打ちタンパク … More Except Principal Investigator トランスポーター / ABC transporter / PEPT1 / 相互作用 / 消化管吸収 / がん多剤耐性克服 / DDS / 多剤耐性克服 / Drug delivery system / EPR効果 / デキストラン / transporter / Dextran / ABCトランスポーター / 多剤耐性 / 薬物送達システム / デキストラン誘導体 / 重金属 / 排泄促進 / セシウム / 結合定数 / 価数 / イオン半径 / アルギン酸 / Indoxyl Sulfate / 小腸 / 消化管分泌 / インドキシル硫酸 / 尿毒症 / 腎不全 / 消化管 / 消化管吸 / 臨床試験 / ミルク / PEPT-1 / 薬物-食物間相互作用 / 薬物相互作用 / 医薬品副作用 / P-糖蛋白質 / P-糖タンパク質 / 血液脳関門 / オセルタミビル Less

血液脳関門におけるP-糖タンパク質の機能不全を伴う自殺企図機構の解析Principal Investigator
- Principal Investigator
  
  荻原琢男
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Science
Mechanisms of suicide attempts by loss of P-glycoprotein function in the blood-brain barrierPrincipal Investigator
- Principal Investigator
  
  荻原琢男
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Takasaki University of Health and Welfare
Mechanism and clinical prediction of drug resistance associated with epithelial mesenchymal transition of lung cancerPrincipal Investigator
- Principal Investigator
  
  Ogihara Takuo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Takasaki University of Health and Welfare
Development of cancer-specific drug carriers possessing comprehensive inhibitory effect of ABC transporters
- Principal Investigator
  
  Morimoto Kaori
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Organ-specific inactivation of cancer multidrug resistance by regulating membrane scaffold proteinsPrincipal Investigator
- Principal Investigator
  
  Ogihara Takuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Takasaki University of Health and Welfare
Evaluation of the intestinal secretion of indoxyl sulfate as a possible compensative excretion pathway in chronic kidney disease
- Principal Investigator
  
  MORIMOTO Kaori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku Pharmaceutical University
Study of alginate's effect and mechanism, enhancing excretion and reducing absorption of strontium and cesium.
- Principal Investigator
  
  Idota Yoko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Eating habits
- Research Institution
  Takasaki University of Health and Welfare
The construction of a means to overcome cancerous multidrug resistance by mediating the post-translational regulators of drug-efflux transportersPrincipal Investigator
- Principal Investigator
  
  OGIHARA Takuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Takasaki University of Health and Welfare
Effect of Food on the Intestinal PEPT1-mediated Drug Absorption
- Principal Investigator
  
  MORIMOTO Kaori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Takasaki University of Health and Welfare
The mechanism and its inter-individual variability of the Blood-Brain Barrier penetration of anti-influenza drug, oseltamivir
- Principal Investigator
  
  MORIMOTO Kaori
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Takasaki University of Health and Welfare

[Book] 実践製剤学－そしてその基礎となる物理薬剤学2015
- Author(s)
  安藤英紀，飯村菜穂子，石田竜弘，井戸田陽子，荻原琢男
- Total Pages
  519
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-15K08078
[Book] 実践　製剤学　そしてその基盤となる物理薬剤学2015
- Author(s)
  安藤英紀, 飯村菜穂子, 石田竜弘, 井戸田陽子, 荻原琢男
- Total Pages
  519
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-25560062
[Book] 第1章総論, わかりやすい生物薬剤学第5版2014
- Author(s)
  荻原琢男
- Total Pages
  10
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-24590667
[Book] 2 試料の調製および分析法, 薬剤学実験法必携マニュアル Pharmaceutical Scientistのために Ⅱ 生物薬剤学2014
- Author(s)
  荻原琢男, 井戸田陽子
- Total Pages
  14
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-24590667
[Book] 2 試料の調製および分析法, 薬剤学実験法必携マニュアル Pharmaceutical Scientistのために Ⅱ 生物薬剤学2014
- Author(s)
  荻原琢男, 井戸田陽子
- Total Pages
  423
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25560062
[Book] 薬剤学実験法必携マニュアル2014
- Author(s)
  荻原琢男、井戸田陽子
- Total Pages
  768
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25560062
[Book] 薬剤学実験法必携マニュアル　生物薬剤学2013
- Author(s)
  荻原琢男，井戸田陽子
- Total Pages
  423
- Publisher
  日本薬剤学会出版委員会（南江堂）
- Data Source
  KAKENHI-PROJECT-24590667
[Book] DDS製剤の開発・評価と実用化手法,2013
- Author(s)
  荻原琢男,　井戸田陽子
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-24590667
[Book] ＤＤＳ製剤の開発・評価と実用化手法2013
- Author(s)
  荻原琢男，井戸田陽子
- Total Pages
  680
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-24590667
[Book] トランスポーター科学最前線2008
- Author(s)
  荻原琢男ら
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-19599023
[Book] 創薬支援研究の展望2008
- Author(s)
  荻原琢男ら
- Publisher
  株式会社シーエムシー出版
- Data Source
  KAKENHI-PROJECT-19599023
[Book] トランスポーター科学最前線2008
- Author(s)
  荻原琢男、森本かおり
- Publisher
  京都廣川書店
- Data Source
  KAKENHI-PROJECT-19599023
[Book] 創薬支援研究の展望2008
- Author(s)
  荻原琢男、森本かおり、玉井郁巳
- Publisher
  株式会社シーエムシー出版
- Data Source
  KAKENHI-PROJECT-19599023
[Journal Article] Impact of P-Glycoprotein-Mediated Drug-Endogenous Substrate Interactions on Androgen and Blood-Brain Barrier Permeability.2024
- Author(s)
  Hiroki Sunakawa, Kenta Mizoi, Reiko Takahashi, Saori Takahashi, Takuo Ogihara.
- Journal Title
  
  Journal of Pharmaceutical Sciences.
  
  Volume: 113 Issue: 1 Pages: 228-234
- DOI
  10.1016/j.xphs.2023.10.034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06774
[Journal Article] Functional Alterations of Multidrug Resistance-Associated Proteins 2 and 5, and Breast Cancer Resistance Protein upon Snail-Induced Epithelial–Mesenchymal Transition in HCC827 Cells2021
- Author(s)
  Yano Kentaro、Todokoro Itsuki、Kamioka Hiroki、Tomono Takumi、Ogihara Takuo
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 1 Pages: 103-111
- DOI
  10.1248/bpb.b20-00693
- NAID
  130007965328
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-01-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06793, KAKENHI-PROJECT-19K16451
[Journal Article] Physiological Roles of ERM Proteins and Transcriptional Regulators in Supporting Membrane Expression of Efflux Transporters as Factors of Drug Resistance in Cancer2020
- Author(s)
  Ogihara Takuo、Mizoi Kenta、Kamioka Hiroki、Yano Kentaro
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 11 Pages: 3352-3352
- DOI
  10.3390/cancers12113352
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16451, KAKENHI-PROJECT-18K06793
[Journal Article] Regulation of breast cancer resistance protein and P‐glycoprotein by ezrin, radixin and moesin in lung, intestinal and renal cancer cell lines2020
- Author(s)
  Kentaro Yano, Chiaki Okabe, Kenta Fujii, Yuko Kato, Takuo Ogihara
- Journal Title
  
  Journal of Pharmacy and Pharmacology
  
  Volume: 72 Issue: 4 Pages: 575-582
- DOI
  10.1111/jphp.13225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16451, KAKENHI-PROJECT-18K06793
[Journal Article] Moesin-Mediated P-Glycoprotein Activation During Snail-Induced Epithelial-Mesenchymal Transition in Lung Cancer Cells2020
- Author(s)
  Kamioka Hiroki、Tomono Takumi、Fujita Atsushi、Onozato Ryoichi、Iijima Misa、Tsuchida Shigeru、Arai Takahiro、Fujita Yukiyoshi、Zhang Xieyi、Yano Kentaro、Ogihara Takuo
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 109 Issue: 7 Pages: 2302-2308
- DOI
  10.1016/j.xphs.2020.03.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16451, KAKENHI-PROJECT-18K06793
[Journal Article] Testosterone and androstenedione are endogenous substrates of P-glycoprotein2019
- Author(s)
  Yano Kentaro、Seto Saeka、Kamioka Hiroki、Mizoi Kenta、Ogihara Takuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 520 Issue: 1 Pages: 166-170
- DOI
  10.1016/j.bbrc.2019.09.067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06793, KAKENHI-PROJECT-19K16451
[Journal Article] Advances in Studies of P-Glycoprotein and Its Expression Regulators2018
- Author(s)
  Yano Kentaro、Tomono Takumi、Ogihara Takuo
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 1 Pages: 11-19
- DOI
  10.1248/bpb.b17-00725
- NAID
  130006301301
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06793, KAKENHI-PROJECT-16K18956
[Journal Article] Entinostat reverses P-glycoprotein activation in snail-overexpressing adenocarcinoma HCC827 cells2018
- Author(s)
  Tomono Takumi、Machida Tatsuya、Kamioka Hiroki、Shibasaki Yumi、Yano Kentaro、Ogihara Takuo
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 7 Pages: e0200015-e0200015
- DOI
  10.1371/journal.pone.0200015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06793, KAKENHI-PROJECT-16K18956
[Journal Article] Snail-Induced Epithelial-to-Mesenchymal Transition Enhances P-gp-Mediated Multidrug Resistance in HCC827 Cells2017
- Author(s)
  Tomono Takumi、Yano Kentaro、Ogihara Takuo
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 106 Issue: 9 Pages: 2642-2649
- DOI
  10.1016/j.xphs.2017.03.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18956, KAKENHI-PROJECT-15K08078
[Journal Article] Effect of Phosphate Binder on the Intestinal Absorption of Antihypertensive Drugs2017
- Author(s)
  K. Yano, T. Tomono, M. Kanagawa, S. Akiyama, T. Ogihara
- Journal Title
  
  J Community Pharm. Pharm. Sci.
  
  Volume: 9 Pages: 239-245
- NAID
  40021403150
- Data Source
  KAKENHI-PROJECT-15K08078
[Journal Article] Gastrointestinal Hormone Cholecystokinin Increases P-Glycoprotein Membrane Localization and Transport Activity in Caco-2 Cells2017
- Author(s)
  Yano Kentaro、Shimizu Saori、Tomono Takumi、Ogihara Takuo
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 106 Issue: 9 Pages: 2650-2656
- DOI
  10.1016/j.xphs.2017.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18956, KAKENHI-PROJECT-15K08078
[Journal Article] Different Regulation of P-Glycoprotein Function between Caco-2 and Caki-1 cells by ERM proteins2016
- Author(s)
  Yano K, Otsuka K, Kato Y, Kawabata H, Ohmori S, Arakawa H, Ogihara T.
- Journal Title
  
  J Pharm Pharmacol.
  
  Volume: 68 Issue: 3 Pages: 361-367
- DOI
  10.1111/jphp.12525
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078, KAKENHI-PROJECT-15K19014
[Journal Article] Adenovirus vector infection of non-small-cell lung cancer cells is a trigger for multi-drug resistance mediated by P-glycoprotein2016
- Author(s)
  T. Tomono, M. Kajita, K. Yano, T. Ogihara
- Journal Title
  
  Biochem. and Biophys. Res. Commun.
  
  Volume: 476(4) Issue: 4 Pages: 183-187
- DOI
  10.1016/j.bbrc.2016.05.070
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08078
[Journal Article] Cholesterol-Lowering Effect of Calcium Alginate in Rats2016
- Author(s)
  Idota Y, Kogure Y, Kato T, Ogawa M, Kobayashi S, Kakinuma C, Yano K, Arakawa H, Miyajima C, Kasahara F, Ogihara T
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 1 Pages: 62-67
- DOI
  10.1248/bpb.b15-00503
- NAID
  130005116495
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02894, KAKENHI-PROJECT-25560062
[Journal Article] Interaction of Peptide Transporter 1 With d-Glucose and l-Glutamic Acid; Possible Involvement of Taste Receptors.2016
- Author(s)
  Arakawa H, Ohmachi T, Ichiba K, Kamioka H, Tomono T, Kanagawa M, Idota Y, Hatano Y, Yano K, Morimoto K, Ogihara T.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 105 Issue: 1 Pages: 339-342
- DOI
  10.1016/j.xphs.2015.11.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078, KAKENHI-PROJECT-25560062
[Journal Article] Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs.2016
- Author(s)
  Arakawa H, Kamioka H, Kanagawa M, Hatano Y, Idota Y, Yano K, Morimoto K, Ogihara T.
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume: 37 Issue: 1 Pages: 39-45
- DOI
  10.1002/bdd.1999
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078
[Journal Article] Multiple linear regression analysis indicates association of P-glycoprotein substrate or inhibitor character with bitterness intensity, measured with a sensor2015
- Author(s)
  Kentaro Yano, Suzune Mita, Kaori Morimoto, Tamami Haraguchi, Hiroshi Arakawa, Miyako Yoshida, Fumiyoshi Yamashita, Takahiro Uchida, Takuo Ogihara
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 104 Issue: 9 Pages: 2789-2794
- DOI
  10.1002/jps.24232
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22136001, KAKENHI-PLANNED-23136102, KAKENHI-PROJECT-24590667, KAKENHI-PROJECT-25670073
[Journal Article] Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats2015
- Author(s)
  Tomono T, Otsuka K, Yano K, Kanagawa M, Arakawa H, Ogihara T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 12 Pages: 1960-1963
- DOI
  10.1248/bpb.b15-00392
- NAID
  130005112643
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08078
[Journal Article] Characterization of Cesium Uptake Mediated by a Potassium Transport System of Bacteria in a Soil Conditioner2014
- Author(s)
  P. Zhang, Y. Idota, K. Yano, M. Negishi, H. Kawabata, H. Arakawa, K. Morimoto, A. Tsuji, T. Ogihara
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 37 Issue: 4 Pages: 604-607
- DOI
  10.1248/bpb.b13-00871
- NAID
  130003390964
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25560062
[Journal Article] Contribution of radixin to P-glycoprotein expression and transport activity in mouse small intestine in vivo2013
- Author(s)
  Yano K, Tomono T, Sakai R, Kano T, Morimoto K, Kato Y, Ogihara T.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 102（8） Issue: 8 Pages: 2875-81
- DOI
  10.1002/jps.23637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667
[Journal Article] Alginate enhances excretion and reduces absorption of strontium and cesium in rats2013
- Author(s)
  dota Ｙ, Harada Ｈ, Tomono Ｔ, Kobayashi S, Kaminuma C, Miyajima C, Kasahara F, Ogihara T
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume: 36 Pages: 485-491
- NAID
  130003382090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667
[Journal Article] A new high-throughput analysis for drug metabolism profiling using liquid chromatography coupled with tandem mass spectrometry,2013
- Author(s)
  K. Kusumoto,　T. Nagao, T. Ogihara
- Journal Title
  
  Drug Res.
  
  Volume: 63 Issue: 04 Pages: 1-6
- DOI
  10.1055/s-0033-1333782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667
[Journal Article] Clinical impact and evidence of pharmacokinetic change by genetic polymorphism2013
- Author(s)
  T. Ogihara
- Journal Title
  
  Drug Metab. Pharmacokinet,
  
  Volume: 28 Pages: 3-3
- NAID
  130005435330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667
[Journal Article] The Role of Inter-segmental Differences in P-glycoprotein expression and activityalong the rat small intestine in causing the double-peak phenomenon of substrate plasma concentration2013
- Author(s)
  Wada S, Kano T, Mita S, Idota Y, Morimoto K, Yamashita F, Ogihara T.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: Vo.28 Pages: 98-103
- URL
  https://www.jstage.jst.go.jp/article/dmpk/28/2/28_DMPK-12-RG-005/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590505
[Journal Article] The role of inter-segmental differences in P-glycoprotein expression and activity along the rat small intestine in causing the double-peak phenomenon of substrate plasma concentration2013
- Author(s)
  S. Wada, T. Kano, S. Mita, Y. Idota, K. Morimoto, F. Yamashita, T. Ogihara
- Journal Title
  
  Drug Metab.Pharmacokinet .
  
  Volume: 28 Pages: 98-103
- NAID
  130004933523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667
[Journal Article] Challenges of drug delivery Systems that contribute to cancer chemotherapy2013
- Author(s)
  T. Ogihara
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume: 36 Pages: 691-691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667
[Journal Article] The Role of Inter-segmental Differences in P-glycoprotein Expression and Activity along the Rat Small Intestine in Causing the Double-peak Phenomenon of Substrate Plasma Concentration2013
- Author(s)
  Sho Wada, Takashi Kano,Suzune Mita, Yoko Idota, Kaori Morimoto, Fumiyoshi Yamashita, Takuo Ogihara
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 28 Issue: 2 Pages: 98-103
- DOI
  10.2133/dmpk.DMPK-12-RG-005
- NAID
  130004933523
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590667, KAKENHI-PLANNED-23136102
[Journal Article] Transport mechanism of flavanone aglycones across Caco-2 cell monolayers and artificial PAMPA membranes2012
- Author(s)
  Kobayashi S, Nagai T, Konishi Y, Tanabe S, Morimoto K, Ogihara T
- Journal Title
  
  J Pharm Pharmacol
  
  Volume: Vol.61 Issue: 1 Pages: 52-60
- DOI
  10.1111/j.2042-7158.2011.01374.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590505
[Journal Article] Species difference of esterase expression and hydrolase activity in plasma2012
- Author(s)
  Bahar F.G., Ohura K., Ogihara T., Imai T
- Journal Title
  
  J. Pharm. Sci
  
  Volume: Vol. 101 Issue: 10 Pages: 3979-3988
- DOI
  10.1002/jps.23258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590505
[Journal Article] Developmental changes of brain distribution and localization of oseltamivir and its active metabolite Ro 64-0802 in rats2012
- Author(s)
  Morimoto K, Nagami T, Matsumoto N, Wada S, Kano T, Kakinuma, Ogihara T
- Journal Title
  
  J Toxicol Sci
  
  Volume: Vol.37 Pages: 1217-1223
- NAID
  10031126025
- URL
  https://www.jstage.jst.go.jp/article/jts/37/6/37_1217/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590505
[Journal Article] 食品成分と薬物の相互作用2011
- Author(s)
  小林彰子, 森本かおり, 荻原琢男
- Journal Title
  
  BIOINDUSTRY
  
  Volume: 28巻 Pages: 30-35
- URL
  http://www.fujisan.co.jp/product/1281680662/b/691304/
- Data Source
  KAKENHI-PROJECT-22590505
[Journal Article] Effect of milk on the pharmacokinetics of oseltamivir in healthy volunteers2011
- Author(s)
  Morimoto K, Kishimura K, Nagami T, Kodama N, Ogama Y, Yokoyama M, Toda S, Chiyoda T, Shimada R, Inano A, Kano T, Tamai I, Ogihara T
- Journal Title
  
  J. Pharm. Sci
  
  Volume: Vol.100 Issue: 9 Pages: 3854-3861
- DOI
  10.1002/jps.22627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590505
[Journal Article] Oseltamivir (Tamiflu^<TM>)is a substrate of PEPT12009
- Author(s)
  Takuo Ogihara, et al.
- Journal Title
  
  Drug Metab Dispos (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19599023
[Journal Article] Oseltamivir (Tamiflu) Efflux Transport at the Blood-Brain Barrier via P-glycoprotein.2008
- Author(s)
  Morimoto K, Nakakariya M, Shirasaka Y, Kakinuma C, Fujita T, Tamai I, Ogihara T.
- Journal Title
  
  Drug Metab Dispos 36
  
  Pages: 6-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19599023
[Journal Article] Oseltamivir (Tamiflu^<TM>) is a substrate of PEPT1.
- Author(s)
  Ogihara T, Kano T, Wagatsuma T, Wada S, Yabuuchi H, Enomoto S, Morimoto K, Shirasaka Y, Kobayashi S, Tamai I.
- Journal Title
  
  Drug Metab Dispos in press
  
  Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19599023
[Patent] 体内のコレステロール低下剤、飲食品、飼料および医薬品2014
- Inventor(s)
  笠原文善, 宮島千尋, 荻原琢男, 井戸田陽子
- Industrial Property Rights Holder
  笠原文善, 宮島千尋, 荻原琢男, 井戸田陽子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-123351
- Filing Date
  2014-06-16
- Data Source
  KAKENHI-PROJECT-25560062
[Patent] セシウム排泄、有害金属排泄剤、飲食品、飼料および医薬品2013
- Inventor(s)
  笠原文善、宮島千尋、荻原琢男
- Industrial Property Rights Holder
  笠原文善、宮島千尋、荻原琢男
- Industrial Property Rights Type
  特許
- Filing Date
  2013-09-05
- Overseas
- Data Source
  KAKENHI-PROJECT-25560062
[Patent] セシウム排泄剤，有機金属排泄剤，飲食品，飼料および医薬品2013
- Inventor(s)
  笠原文善，宮島千尋，荻原琢男
- Industrial Property Rights Holder
  笠原文善，宮島千尋，荻原琢男
- Industrial Property Rights Type
  特許
- Filing Date
  2013-09-05
- Overseas
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] 自然科学的アプローチとしての分子自殺予防学の構築2024
- Author(s)
  砂川大樹，高橋玲子，塚正彦，古宮淳一, 崔　吉道，張協義，溝井健太，荻原琢男
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K06774
[Presentation] P-糖タンパク質を介した血液脳関門における薬物-内因性基質相互作用の評価2023
- Author(s)
  砂川大樹，高橋玲子，張協義，塚正彦，古宮淳一, 溝井健太，荻原琢男
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-22K06774
[Presentation] P糖タンパク質を介した血液脳関門における薬物-内因性基質相互作用の解析2023
- Author(s)
  砂川大樹、髙橋玲子、張協義、塚正彦、古宮淳一、崔吉道、溝井健太、荻原琢男
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-22K06774
[Presentation] Evaluation of P-gp-mediated drug-endogenous substrate interactions2023
- Author(s)
  H.Snagawa, R.Takahashi, M. Zuka, J.Furumiya, Y,Sai, X.Zhang, K.Mizoi, T.Ogihara
- Organizer
  日本薬物動態学会第38年会
- Data Source
  KAKENHI-PROJECT-22K06774
[Presentation] 血液脳関門におけるP-糖タンパク質を介した薬物-内因性基質相互作用の解明2023
- Author(s)
  砂川大樹，高橋玲子，塚正彦，古宮淳一, 崔吉道, 張協義，溝井健太，荻原琢男
- Organizer
  第７回トランスポーター研究会
- Data Source
  KAKENHI-PROJECT-22K06774
[Presentation] Analysis of drug-endogenous-substrate interaction on blood-brain barrier via P-glycoprotein2022
- Author(s)
  Hiroki Sunakawa, Reiko Takahashi, Kenta Mizoi, Takuo Ogihara
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-22K06774
[Presentation] Dextranによる多剤耐性関連輸送体の阻害効果2021
- Author(s)
  森本かおり, 石井　敬, 杉本　芳一, 荻原　琢男, 富田　幹雄
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06790
[Presentation] Cationic modification gives dextran a BCRP inhibitory effect2021
- Author(s)
  森本かおり, 石井　敬, 杉本　芳一, 荻原　琢男, 富田　幹雄
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-18K06790
[Presentation] Dextranによる多剤耐性関連輸送体の阻害効果2021
- Author(s)
  森本かおり、石井敬、杉本芳一、荻原琢男、富田幹雄
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06790
[Presentation] Physiological roles of ERM proteins in supporting membrane expression of efflux transporters2020
- Author(s)
  X. Zhang, K. Mizoi, H. Kamioka, K. Yano, T. Ogihara
- Organizer
  第5回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] Mechanism of Drug Resistance Through Increased P-glycoprotein Function due to Enhanced Expression of Radixin at Epithelial-Mesenchymal Transition2020
- Author(s)
  H. Kamioka, K. Yano, T. Tomono, T. Ogihara
- Organizer
  日本薬物動態学会第35回年会
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] 肺がん細胞の上皮間葉転換による膜発現調節因子を介したP-糖タンパク質の機能亢進2019
- Author(s)
  上岡宏規, 伴野拓巳, 藤田行代志, 藤田敦, 小野里良一, 飯島美砂, 土田秀, 新井隆広, 矢野健太郎, 荻原琢男
- Organizer
  第41回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] テストステロンはP-糖タンパクの生体内基質である2019
- Author(s)
  溝井健太, 瀬戸彩瑛香, 高橋紗織, 矢野健太郎, 荻原琢男
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] P-糖タンパク質および乳がん耐性タンパク質の輸送機能におけるERMタンパクの関与とその組織差2019
- Author(s)
  矢野健太郎, 岡部千明, 藤井健太, 加藤木綿子, 荻原琢男
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] 肺がん細胞におけるSnail誘発性上皮間葉転換時におけるP-糖タンパク質活性化機構の解明2019
- Author(s)
  上岡宏規, 伴野拓巳, 矢野健太郎, 藤田行代志, 藤田敦, 小野里良一, 飯島美砂, 土田秀, 新井隆広, 荻原琢男
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] 男性ホルモン輸送におけるP-糖タンパク質の関与2019
- Author(s)
  瀬戸彩瑛香, 溝井健太, 高橋紗織, 矢野健太郎, 荻原琢男
- Organizer
  第14回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] P-glycoprotein activation mechanism by Snail-induced epithelial-to-mesenchymal transition in lung cancer cells2019
- Author(s)
  H. Kamioka, T. Tomono, K. Yano, Y. Fujita, A. Fujita, R. Onozato, M. Iijima, S. Tsuchida, T. Arai, T. Ogihara
- Organizer
  ISSX2019, 12th Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] Bitter substance increases P-glycoprotein membrane localization and transport activity via CCK secretion in Caco-2 Cells2019
- Author(s)
  K. Yano, M. Kimura, T. Ogihara
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] 肝臓がんのSnail誘発性上皮間葉転換におけるP-糖タンパク質の機能変化2019
- Author(s)
  笠原悠, 上岡宏規, 矢野健太郎, 荻原琢男
- Organizer
  第14回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] P-glycoprotein activation at epithelial to mesenchymal transition in HepG2 cells2019
- Author(s)
  H. Kamioka, H. Kasahara, K. Yano, T. Ogihara
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] 足場タンパクによる組織選択的なP-糖タンパク質（P-gp）の機能調節2018
- Author(s)
  荻原琢男
- Organizer
  慶應義塾大学大学院生物系薬学特論/薬品機能解析・動態制御学特論
- Invited
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] Gastrointestinal Hormone Cholecystokinin and Bitter Substance Increase P-glycoprotein Membrane Localization and Transport Activity in Caco-2 Cells2018
- Author(s)
  K. Yano, Y. Watanabe, T. Ogihara
- Organizer
  日本薬物動態学会第33回年会/MDO国際合同学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] ピモジドの消化管吸収過程におけるP-糖タンパク質を介した薬物間相互作用の検討2018
- Author(s)
  森下宙輝, 大川こずえ, 荒川大, 矢野健太郎, 荻原琢男
- Organizer
  第3回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] 併用薬物によるP-gp阻害を介したピモジドの消化管吸収の亢進2018
- Author(s)
  大川こずえ, 森下宙輝, 矢野健太郎, 荻原琢男
- Organizer
  第62回　日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-18K06793
[Presentation] HDAC阻害薬EntinostatはEMTに伴うP-gpの機能亢進を抑制する2017
- Author(s)
  町田幸也, 伴野拓巳, 矢野健太郎, 荻原琢男
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Effect of Epithelial-Mesenchymal Transition Induced by Snail on Efflux Transporters2017
- Author(s)
  I. Todokoro, T. Tomono, H. Kamioka, S. Koyama, K. Yano, T. Ogihara
- Organizer
  32nd JSSX Annual Meeting
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 消化管ホルモンであるコレシストキニンによるP-糖タンパク質の細胞膜上発現および輸送機能の亢進2017
- Author(s)
  矢野健太郎, 渡邊弥生, 伴野拓巳, 荻原琢男
- Organizer
  第12回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] The organ-specific regulation of BCRP and P-gp2017
- Author(s)
  C. Okabe, K. Yano, K. Fujii, Y. Kato, S. Koyama, T. Ogihara
- Organizer
  32nd JSSX Annual Meeting
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] P-糖タンパクを介した薬物の脳内移行性の制御 ; OseltamivirとCilnidipineの例2017
- Author(s)
  荻原琢男, 森本かおり, 井戸田陽子, 小山智志, 矢野健太郎
- Organizer
  第39回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Brain Distribution of Spermine, a Neuromodulator, and Change in the Translocation by Breast Cancer Resistance Protein2017
- Author(s)
  K. Yano, Y. Yokozuka, E. Matsumoto, S. Koyama, T. Ogihara
- Organizer
  32nd JSSX Annual Meeting
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 上皮間葉転換によるP-糖タンパク質の機能亢進は肺がん細胞の薬剤耐性能を増強する2017
- Author(s)
  上岡宏規, 伴野拓巳, 矢野健太郎, 荻原琢男
- Organizer
  第12回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Snail-induced Epithelial to Mesenchymal Transition Activates P-gp via Increasing the Scaffolding Protein Moesin2017
- Author(s)
  T. Tomono, H. Kamioka, Y. Shibasaki, S. Koyama, K. Yano, T. Ogihara
- Organizer
  32nd JSSX Annual Meeting
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Snail過剰発現によるP-gp機能亢進におけるCaveolin-1リン酸化の関与2016
- Author(s)
  伴野拓巳、矢野健太郎、荻原琢
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] BCRPを介した脳興奮物質であるSpermineの排出2016
- Author(s)
  横塚弥衣、松本映子、矢野健太郎、荻原琢男
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 肺がん細胞へのリチウム処理によるMRPファミリーの機能変動2016
- Author(s)
  柴﨑由実、伴野拓巳、矢野健太郎、荻原琢男
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Snail過剰発現によるEMTはHCC827細胞におけるBCRPの発現を低下させる2016
- Author(s)
  伴野拓巳, 矢野健太郎, 荻原琢男
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  岐阜
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 肺腺がん細胞へのアデノウイルス感染はAktのリン酸化を介してP-gpの発現を亢進する2016
- Author(s)
  柴﨑由実, 伴野拓巳, 矢野健太郎, 荻原琢男
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  岐阜
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 非小細胞性肺がん細胞へのアデノウイルス感染がBCRPおよびMRPファミリーに及ぼす影響2016
- Author(s)
  伴野拓巳, 矢野健太郎, 荻原琢男
- Organizer
  第11回トランスポーター研究会年会
- Place of Presentation
  京都
- Year and Date
  2016-07-02
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] ヒト腎臓がん細胞のP-gp およびMRPs 輸送機能における足場タンパクの関与2016
- Author(s)
  加藤木綿子、矢野健太郎、井戸田陽子、荒川大、荻原琢男
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Cholesterol-lowering Effect of Calcium Alginate in Rats2016
- Author(s)
  Takuo OGIHARA, Yoko IDOTA, Yumi KOGURE, Takako KATO, Mana OGAWA, Shoko KOBAYASHI, Chihaya KAKINUMA, Kentaro YANO, Hiroshi ARAKAWA, Chihiro MIYAJIMA, Fumiyoshi KASAHARA
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌市教育文化会館（北海道札幌市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] 消化管ホルモンであるコレシストキニンによるP-gp機能調節2016
- Author(s)
  矢野健太郎、清水里織、荻原琢男
- Organizer
  日本薬物動態学会第31年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 基質薬物とキノロン系抗菌薬との　消化管吸収過程における相互作用2015
- Author(s)
  荻原琢男, 上岡宏紀, 金川雅彦, 井戸田陽子, 矢野健太郎, 森本かおり, 荒川大
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本大学薬学部大江キャンパス（熊本県熊本市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] 初代ヒト肝細胞三次元培養法の薬物代謝酵素誘導試験における有用性2015
- Author(s)
  荒川大, 上岡宏紀, 井戸田陽子, 矢野健太郎, 荻原琢男
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] がん組織におけるERMタンパクによるP-gp輸送機能の調節機構2015
- Author(s)
  加藤木綿子、矢野健太郎、大塚杏磨、荒川大、荻原琢男
- Organizer
  第8回トランスポーター研究会
- Place of Presentation
  慶応義塾大学薬学部
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Tissue-selective regulation of P-gp function in cancers by ERM proteins2015
- Author(s)
  矢野　健太郎、大塚　杏磨、加藤　木綿子、井戸田　陽子、荒川　大、荻原　琢男
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  東京　タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 尿毒症物質インドキシル硫酸の消化管分泌機構の解析2015
- Author(s)
  富永雄太、森本かおり、宮本将成、柏倉正太、高橋昂、佐野芳美、矢野健太郎、荻原琢男、富田幹雄
- Organizer
  日本薬物動態学会第３０年会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460196
[Presentation] アルギン酸による重金属吸着作用の解析2015
- Author(s)
  荻原琢男, 井戸田陽子, 加藤多佳子, 矢野健太郎, 荒川大, 安竹良礼, 宮島千尋, 笠原文善
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] インドキシル硫酸の代償性排泄経路としての消化管分泌の関与2015
- Author(s)
  富永雄太、森本かおり、宮本将成、柏倉正太、高橋昂、佐野芳美、矢野健太郎、荻原琢男、富田幹雄
- Organizer
  第９回日本腎臓病薬物療法学会学術集会・総会2015
- Place of Presentation
  仙台国際センター(宮城県仙台市）
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-25460196
[Presentation] 服用者および調剤者の立場からの既存錠2錠と倍量大型錠1錠の比較検討2015
- Author(s)
  金井佑樹, 矢野健太郎, 井戸田陽子, 荒川大, 井上拓民, 林正弘, 荻原琢男
- Organizer
  第11回群馬県薬剤師学会学術大会
- Place of Presentation
  ベイシア文化ホール（群馬県前橋市）
- Year and Date
  2015-05-31
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] 基質薬物とキノロン系抗菌薬との消化管吸収過程における相互作用2015
- Author(s)
  荻原　琢男、上岡　宏紀、金川　雅彦、井戸田　陽子、矢野　健太郎、森本　かおり、荒川　大
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Utility of three-dimensional culture of human hepatocyte as a tool of drug metabolizing enzyme induction2015
- Author(s)
  荒川　大、上岡　宏紀、井戸田　陽子、矢野　健太郎、荻原　琢男
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  東京　タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 日米EU3局の薬物相互作用ガイドラインの概要まとめと比較2015
- Author(s)
  山田　浩行、荒川　大、楠本　久美子、小島　肇、荻原　琢男
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  船橋
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] Transcriptional factor Snail activates P-glycoprotein function in lung adenocarcinoma cells2015
- Author(s)
  伴野　拓巳、矢野　健太郎、荒川　大、荻原　琢男
- Organizer
  日本薬物動態学会第30年会
- Place of Presentation
  東京　タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08078
[Presentation] 尿毒症物質インドキシル硫酸の消化管粘膜透過機構の解析2014
- Author(s)
  宮本将成、我妻雄太、野呂悠佳、森本かおり、矢野健太郎、荻原拓男、富田幹雄．
- Organizer
  第53回日本薬学会東北支部大会
- Place of Presentation
  いわき明星大学（福島県いわき市）
- Year and Date
  2014-10-05
- Data Source
  KAKENHI-PROJECT-25460196
[Presentation] アルギン酸による血中コレステロール低下作用2014
- Author(s)
  安竹良礼, 井戸田陽子, 木暮悠美, 加藤多佳子, 矢野健太郎, 荒川大, 柿沼千早, 宮島千尋, 笠原文善, 小林彰子, 荻原琢男
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] RadixinによるP-gp機能調節の臓器差2014
- Author(s)
  大塚杏磨, 矢野健太郎, 川端秀明, 金井祐樹, 伴野拓巳, 荒川大, 荻原琢男
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] Contribution of radixin to P-glycoprotein expression and transport activity2013
- Author(s)
  Yano K, Tomono T, Kawabata H, Idota Y, Morimoto K, Arakawa H, Ogihara T
- Organizer
  28ｔｈ JSSX Annual Meeting,
- Place of Presentation
  Ｔｏｋｙｏ
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] Contribution of radixin to P-glycoprotein expression and transport activity in mouse small intestine in vivo,2013
- Author(s)
  伴野拓巳,　矢野健太郎,　川端秀明,　荒川大,　荻原琢男
- Organizer
  第8回トランスポーター研究会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] Alginate Enhances Excretion and Reduces Absorption of Strontium and Cesium in Rats2013
- Author(s)
  Yumi Kogure, Yoko Idota, Hitomi Harada, Shoko Kobayashi, Chihaya Kakinuma, Chihiro Miyajima, Fumiyoshi Kasahara, Takuo Ogihara
- Organizer
  Asian Federation for Pharmaceutical Sciences (AFPS) 2013 -アジア薬科学会議2013-
- Place of Presentation
  済州島, 韓国
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] In　vitroによる薬物代謝スクリーニングの現状と留意点,2013
- Author(s)
  荻原琢男,　井戸田陽子
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] Double-peak phenomena caused by intestinal segmental difference of P-glycoprotein activity,2013
- Author(s)
  Wada S, Ogihara T, Nakanishi T, Tamai
- Organizer
  4th ISSX/CSSX Joint Workshop
- Place of Presentation
  Henan, China
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] Contribution of radixin in segmental difference of P-glycoprotein expression in small intestine2012
- Author(s)
  伴野　拓巳、酒井　理予、矢野　健太郎、叶　隆、森本　かおり、加藤　将夫、荻原　琢男
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  千葉（タワーホール船堀）
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] Radixin is involved in P-glycoprotein expression in small intestine2012
- Author(s)
  酒井　理予、叶　隆、和田　翔、森本　かおり、荻原　琢男
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸(神戸国際会議場）
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] Oseltamivir (Tamiflu^<TM>)is a substrate of PEPT12009
- Author(s)
  Takuo Ogihara, et al.
- Organizer
  3rd Asian Pacific Regional ISSX Meeting
- Place of Presentation
  Bangkok, Thailand(発表確定)
- Year and Date
  2009-05-11
- Data Source
  KAKENHI-PROJECT-19599023
[Presentation] オセルタミビルはヒトペプチドトランスポーターPEPT1の基質である2009
- Author(s)
  荻原琢男ら
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19599023
[Presentation] オセルタミビルはヒトペプチドトランスポーターPEPT1の基質である2009
- Author(s)
  荻原琢男ら
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都国際会館(京都)
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19599023
[Presentation] Oseltamivir (Tamiflu^<TM>) is a substrate of PEPT1.2009
- Author(s)
  Ogihara T, et al.
- Organizer
  3rd Asia Pacific Regional ISSX Meeting
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-19599023
[Presentation] Effects of Calcium Alginate on Lowering Cholesterol in Rats
- Author(s)
  T. Yasutake, Y. Idota, Y. Kogure, T. Kato, K. Yano, H. Arakawa, C. Kakinuma, C. Miyajima, F. Kasahara, S. Kobayashi, T. Ogihara
- Organizer
  第2回薬食国際カンファレンス
- Place of Presentation
  静岡
- Year and Date
  2014-11-05 – 2014-11-06
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] 消化管P-糖タンパク質の輸送機能に対するゴマリグナンの影響
- Author(s)
  大塚杏磨, 伴野拓巳, 矢野健太郎, 金川雅彦, 荒川大, 荻原琢男
- Organizer
  第135回日本薬学会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] P-糖タンパク機能発現におけるRadixinの役割
- Author(s)
  川端秀明,　矢野健太郎,　伴野拓巳,　荒川　大,　荻原琢男
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] 苦味センサーを用いたP-糖タンパクの基質認識性の解析
- Author(s)
  三田鈴音,　矢野健太郎,　荒川　大,　原口珠実,　吉田　都,　内田享弘,　荻原琢男
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] SSRIおよびSNRIによるK+チャネル阻害作用のPK/PD解析
- Author(s)
  伴野拓巳, 橋場弘武, 矢野健太郎, 井戸田陽子, 荒川大, 林正弘, 荻原琢男
- Organizer
  第24回日本医療薬学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-09-27 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] 薬の運び屋トランスポーターその働きを培養細胞で観察しよう
- Author(s)
  荻原琢男
- Organizer
  日本学術振興会ひらめき☆ときめきサイエンス
- Place of Presentation
  高崎
- Invited
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] アルギン酸による重金属の吸収抑制および排泄促進作用とそのメカニズムの検討
- Author(s)
  荻原琢男, 井戸田陽子, 木暮悠美, 原田瞳, 河合妙子, 矢野健太郎, 柿沼千早, 宮島千尋, 笠原文善
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] 高リン血症治療薬に対する併用注意剤の吸着性解析
- Author(s)
  安部有紀, 伴野拓巳, 秋山滋男, 井戸田陽子, 矢野健太郎, 荒川大, 磯野淳一, 林正弘, 荻原琢男
- Organizer
  第24回日本医療薬学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-09-27 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] P-glycoprotein Plays a Key Role in the Contractionary Effects against Brain Infarction of
- Author(s)
  Takumi Tomono, Kentaro Yano, Toshimitsu Motegi, Shinobu Takimoto, Mihoko Hagiwara, Yoko Idota, Takashi Kano, Hiroshi Arakawa, Kaori Morimoto, Chihaya Kakinuma, Akira Takahara, Takuo Ogihara
- Organizer
  19th North American ISSX/29th JSSX Meeting
- Place of Presentation
  サンフランシスコ
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] アルギン酸による重金属吸着作用の解析
- Author(s)
  荻原琢男，加藤多佳子，井戸田陽子，矢野健太郎，荒川大，安竹良礼，宮島千尋，笠原文善
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29 – 2015-07-01
- Data Source
  KAKENHI-PROJECT-25560062
[Presentation] トランスポーター科学と薬物動態学の最前線,
- Author(s)
  出口芳春,　荻原琢男
- Organizer
  第57回日本薬学会関東支部大会,
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] 薬物の苦味によるP-糖タンパクの基質認識性の予測
- Author(s)
  三田鈴音, 矢野健太郎, 荒川大, 原口珠実, 吉田都, 内田享弘, 荻原琢男
- Organizer
  日本薬剤学会第29回年会
- Place of Presentation
  大宮
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-24590667
[Presentation] ヒト癌細胞のP-gp輸送活性に対するradixinの関与
- Author(s)
  川端秀明, 矢野健太郎, 大塚杏磨, 金井祐樹, 伴野拓巳, 荒川大, 荻原琢男
- Organizer
  第9回トランスポーター研究会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-06-14 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-24590667

1. MORIMOTO Kaori (90401009)

# of Collaborated Projects: 6 results

# of Collaborated Products: 21 results
2. KENTARO Yano (40644290)

# of Collaborated Projects: 5 results

# of Collaborated Products: 72 results
3. IDOTA Yoko (90629594)

# of Collaborated Projects: 4 results

# of Collaborated Products: 34 results
4. TAMAI Ikumi (20155237)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. KANO Takashi (70509257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. MASAHIRO Kajita (40591871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TOMITA Mikio (60207610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. ZHANG Pengyao (80643311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Arakawa Hiroshi (40709028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
10. 石井敬 (00735714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 塚正彦 (00272956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. 崔吉道 (40262589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 古宮淳一 (60363280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. 溝井健太 (70849546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
15. 隹吉道

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
16. 山下富義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ogihara Takuo 荻原 琢男

OGIHARA Takuo 荻原 琢男

Research Projects

Research Products

Co-Researchers

血液脳関門におけるP-糖タンパク質の機能不全を伴う自殺企図機構の解析Principal Investigator

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Mechanisms of suicide attempts by loss of P-glycoprotein function in the blood-brain barrierPrincipal Investigator

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Mechanism and clinical prediction of drug resistance associated with epithelial mesenchymal transition of lung cancerPrincipal Investigator

Principal Investigator

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Development of cancer-specific drug carriers possessing comprehensive inhibitory effect of ABC transporters

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Organ-specific inactivation of cancer multidrug resistance by regulating membrane scaffold proteinsPrincipal Investigator

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Evaluation of the intestinal secretion of indoxyl sulfate as a possible compensative excretion pathway in chronic kidney disease

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Study of alginate's effect and mechanism, enhancing excretion and reducing absorption of strontium and cesium.

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The construction of a means to overcome cancerous multidrug resistance by mediating the post-translational regulators of drug-efflux transportersPrincipal Investigator

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Effect of Food on the Intestinal PEPT1-mediated Drug Absorption

Principal Investigator

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The mechanism and its inter-individual variability of the Blood-Brain Barrier penetration of anti-influenza drug, oseltamivir

Principal Investigator

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[Book] 実践製剤学－そしてその基礎となる物理薬剤学2015

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[Book] 実践 製剤学 そしてその基盤となる物理薬剤学2015

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[Book] 第1章 総論, わかりやすい生物薬剤学 第5版2014

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Total Pages

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Data Source

Ogihara Takuo 荻原琢男

OGIHARA Takuo 荻原琢男

[Book] 実践　製剤学　そしてその基盤となる物理薬剤学2015

[Book] 第1章総論, わかりやすい生物薬剤学第5版2014

[Book] 薬剤学実験法必携マニュアル　生物薬剤学2013