Ohoka Nobumichi 大岡伸通

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OHOKA Nobumichi 大岡伸通

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Researcher Number	80568519
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 遺伝子医薬部, 室長
Affiliation (based on the past Project Information) *help	2016 – 2024: 国立医薬品食品衛生研究所, 遺伝子医薬部, 室長 2014 – 2015: 国立医薬品食品衛生研究所, 遺伝子医薬部, 主任研究官 2011 – 2013: 国立医薬品食品衛生研究所, 機能生化学部, 主任研究官
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Biological pharmacy / Basic Section 37030:Chemical biology-related Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator ユビキチン / プロテアソーム / E3リガーゼ / PROTAC / SNIPER / 標的タンパク質分解 / IAP / 分子標的薬 / プロテインノックダウン / プロテインノックダウン法 … More / キメラ化合物 / 細胞死 / がん / TACC3 / UBCドメイン / アポトーシス / 小胞体ストレス / Apollon … More Except Principal Investigator 蛋白質 / 核内受容体 / ペプチド / プロテアソーム / ユビキチン / 蛋白質分解 / Notch / エストロゲン受容体 / ヘリカルペプチド / SNIPER / プロテインノックダウン Less

新規E3リガーゼを利用した標的タンパク質分解手法の基盤構築と安全性評価Principal Investigator
- Principal Investigator
  
  大岡伸通
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  National Institute of Health Sciences
がん特異的に発現するE3リガーゼを利用したプロテインノックダウン法の基盤構築Principal Investigator
- Principal Investigator
  
  大岡伸通
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  National Institute of Health Sciences
Development of small molecule chimeras that recruit a new E3 ligase to target proteinsPrincipal Investigator
- Principal Investigator
  
  Ohoka Nobumichi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  National Institute of Health Sciences
Design of peptide ligands based on protein-protein interaction and their application to protein knockdown technology
- Principal Investigator
  
  Naito Mikihiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health Sciences
Development of novel small molecules degrading microtubule-associated proteinsPrincipal Investigator
- Principal Investigator
  
  Ohoka Nobumichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health Sciences
Analysis of the molecular mechanism of ER stress regulation by a giant ubiquitin ligase, ApollonPrincipal Investigator
- Principal Investigator
  
  OHOKA Nobumichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health Sciences

[Book] 実験医学2020年9月号, キメラ化合物PROTAC/SNIPERの作用機序と新たな開発の動向2020
- Author(s)
  大岡伸通, 内藤幹彦
- Total Pages
  5
- Publisher
  羊土社
- ISBN
  9784758125352
- Data Source
  KAKENHI-PROJECT-18K06567
[Book] 実験医学増刊, 標的タンパク質を分解する新しい低分子医薬モダリティ2020
- Author(s)
  大岡伸通, 内藤幹彦
- Total Pages
  7
- Publisher
  羊土社
- ISBN
  9784758103893
- Data Source
  KAKENHI-PROJECT-18K06567
[Book] 実験医学2018年11月号（Next Tech Review）2018
- Author(s)
  大岡伸通, 内藤幹彦
- Total Pages
  8
- Publisher
  羊土社
- ISBN
  9784758125130
- Data Source
  KAKENHI-PROJECT-18K06567
[Journal Article] Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins.2024
- Author(s)
  Yokoo H, Tsuji G, Inoue T, Naito M, Demizu Y, Ohoka N.
- Journal Title
  
  Bioorg Chem.
  
  Volume: 145 Pages: 107204-107204
- DOI
  10.1016/j.bioorg.2024.107204
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-22K15257, KAKENHI-PLANNED-23H04926, KAKENHI-PROJECT-21H02777
[Journal Article] Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation.2024
- Author(s)
  Xu H, Ohoka N, Inoue T, Yokoo H, Demizu Y.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 107 Pages: 129778-129778
- DOI
  10.1016/j.bmcl.2024.129778
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-22K15257
[Journal Article] Development of STING degrader with double covalent ligands.2024
- Author(s)
  Nakamura M, Ohoka N, Shibata N, Inoue T, Tsuji G, Demizu Y.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 102 Pages: 129677-129677
- DOI
  10.1016/j.bmcl.2024.129677
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06490, KAKENHI-PLANNED-23H04926
[Journal Article] Structural Optimization of Decoy Oligonucleotide-Based PROTAC That Degrades the Estrogen Receptor.2023
- Author(s)
  Naganuma M, Ohoka N, Tsuji G, Inoue T, Naito M, Demizu Y.
- Journal Title
  
  Bioconjug Chem.
  
  Volume: 34 Issue: 10 Pages: 1780-1788
- DOI
  10.1021/acs.bioconjchem.3c00332
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-22KJ2565, KAKENHI-PLANNED-23H04926
[Journal Article] Development of DNA Aptamer-Based PROTACs That Degrade the Estrogen Receptor.2023
- Author(s)
  Tsujimura H, Naganuma M, Ohoka N, Inoue T, Naito M, Tsuji G, Demizu Y.
- Journal Title
  
  ACS Med Chem Lett.
  
  Volume: 14 Issue: 6 Pages: 827-832
- DOI
  10.1021/acsmedchemlett.3c00126
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-22KJ2565, KAKENHI-PLANNED-23H04926, KAKENHI-PROJECT-21H02777
[Journal Article] Molecular Design, Synthesis, and Evaluation of SNIPER (ER) that Induces Targeted Protein Degradation of ERα2022
- Author(s)
  Ohoka N, Yokoo H, Okuhira K, Demizu Y, Naito M.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2418 Pages: 363-382
- DOI
  10.1007/978-1-0716-1920-9_20
- ISBN
  9781071619193, 9781071619209
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-21K05320, KAKENHI-PLANNED-18H05502
[Journal Article] Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles2022
- Author(s)
  Xu Hanqiao、Kurohara Takashi、Takano Reina、Yokoo Hidetomo、Shibata Norihito、Ohoka Nobumichi、Inoue Takao、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  ChemistryOpen
  
  Volume: 11 Issue: 7
- DOI
  10.1002/open.202200131
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06075, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
[Journal Article] Development of Gilteritinib-Based Chimeric Small Molecules that Potently Induce Degradation of FLT3-ITD Protein2022
- Author(s)
  Ohoka Nobumichi、Suzuki Masanori、Uchida Takuya、Tsuji Genichiro、Tsukumo Yoshinori、Yoshida Masayuki、Inoue Takao、Demizu Yosuke、Ohki Hitoshi、Naito Mikihiko
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 13 Issue: 12 Pages: 1885-1891
- DOI
  10.1021/acsmedchemlett.2c00402
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-19K07724, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
[Journal Article] Development of a potent small-molecule degrader against oncogenic BRAFV600E protein that evades paradoxical MAPK activation.2022
- Author(s)
  Ohoka N, Suzuki M, Uchida T, Tsukumo Y, Yoshida M, Inoue T, Ohki H, Naito M.
- Journal Title
  
  Cancer Sci.
  
  Volume: 113 Issue: 8 Pages: 2828-2838
- DOI
  10.1111/cas.15401
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-19K07724, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
[Journal Article] Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation2021
- Author(s)
  Yokoo Hidetomo、Ohoka Nobumichi、Takyo Mami、Ito Takahito、Tsuchiya Keisuke、Kurohara Takashi、Fukuhara Kiyoshi、Inoue Takao、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 16 Pages: 8772-8772
- DOI
  10.3390/ijms22168772
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-20K22711
[Journal Article] Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands2021
- Author(s)
  Naganuma M, Ohoka N, Tsuji G, Tsujimura H, Matsuno K, Inoue T, Naito M, Demizu Y.
- Journal Title
  
  ACS Med Chem Lett.
  
  Volume: 13 Issue: 1 Pages: 134-139
- DOI
  10.1021/acsmedchemlett.1c00629
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-22KJ2565, KAKENHI-PROJECT-21K05320, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
[Journal Article] Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors2020
- Author(s)
  Yokoo Hidetomo、Ohoka Nobumichi、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 15 Pages: 115595-115595
- DOI
  10.1016/j.bmc.2020.115595
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502
[Journal Article] Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety.2020
- Author(s)
  Shoda T, Ohoka N, Tsuji G, Fujisato T, Inoue H, Demizu Y, Naito M, Kurihara M.
- Journal Title
  
  Pharmaceuticals (Basel).
  
  Volume: 13 Issue: 3 Pages: 34-34
- DOI
  10.3390/ph13030034
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05502, KAKENHI-ORGANIZER-18H05497
[Journal Article] SNIPERs - Hijacking IAP activity to induce protein degradation.2019
- Author(s)
  Naito M, Ohoka N, Shibata N.
- Journal Title
  
  Drug Discovery Today: Technology
  
  Volume: 印刷中 Pages: 481-488
- DOI
  10.1016/j.ddtec.2018.12.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502
[Journal Article] Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)2019
- Author(s)
  Ohoka Nobumichi、Ujikawa Osamu、Shimokawa Kenichiro、Sameshima Tomoya、Shibata Norihito、Hattori Takayuki、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 3 Pages: 203-209
- DOI
  10.1248/cpb.c18-00567
- NAID
  130007607114
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-03-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs.2019
- Author(s)
  Naito M, Ohoka N, Shibata N, Tsukumo Y.
- Journal Title
  
  Front Chem.
  
  Volume: 7 Pages: 849-849
- DOI
  10.3389/fchem.2019.00849
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07724, KAKENHI-PLANNED-18H05502
[Journal Article] Development of small molecule chimeric degraders that bring target proteins and the aryl hydrocarbon receptor (AhR) E3 ligase into close proximity2019
- Author(s)
  N. Ohoka, G. Tsuji, T. Shoda, T. Fujisato, M. Kurihara, Y. Demizu, M. Naito*
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 14 Issue: 12 Pages: 2822-2832
- DOI
  10.1021/acschembio.9b00704
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16K08340
[Journal Article] Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein2019
- Author(s)
  Shibata Norihito、Ohoka Nobumichi、Hattori Takayuki、Naito Mikihiko
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 3 Pages: 165-172
- DOI
  10.1248/cpb.c18-00703
- NAID
  130007606378
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-03-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation2018
- Author(s)
  Ohoka Nobumichi、Morita Yoko、Nagai Katsunori、Shimokawa Kenichiro、Ujikawa Osamu、Fujimori Ikuo、Ito Masahiro、Hayase Youji、Okuhira Keiichiro、Shibata Norihito、Hattori Takayuki、Sameshima Tomoya、Sano Osamu、Koyama Ryokichi、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 18 Pages: 6776-6790
- DOI
  10.1074/jbc.ra117.001091
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase2018
- Author(s)
  Shibata Norihito、Shimokawa Kenichiro、Nagai Katsunori、Ohoka Nobumichi、Hattori Takayuki、Miyamoto Naoki、Ujikawa Osamu、Sameshima Tomoya、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 13549-13549
- DOI
  10.1038/s41598-018-31913-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Development of Protein Knockdown Technology as Emerging Drug Discovery Strategy2018
- Author(s)
  Ohoka Nobumichi
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 138 Issue: 9 Pages: 1135-1143
- DOI
  10.1248/yakushi.18-00113
- NAID
  130007474947
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2018-09-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06567
[Journal Article] SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.2017
- Author(s)
  Ohoka, N., Nagai, K., Shibata, N., Hattori, T., Nara, H., Cho, N. & Naito, M.
- Journal Title
  
  Cancer Sci
  
  Volume: 108 Issue: 5 Pages: 1032-1041
- DOI
  10.1111/cas.13198
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121
[Journal Article] Development of a peptide-based inducer of protein degradation targeting NOTCH12017
- Author(s)
  Ohoka N, Misawa T, Kurihara M, Demizu Y, Naito M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 27 Issue: 22 Pages: 4985-4988
- DOI
  10.1016/j.bmcl.2017.10.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
[Journal Article] Simple and efficient knockdown of His-tagged proteins by ternary molecules consist of His-tag ligand, ubiquitin ligase ligand and cell penetrating peptide2017
- Author(s)
  T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 Issue: 18 Pages: 4478-4481
- DOI
  10.1016/j.bmcl.2017.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
[Journal Article] Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.2017
- Author(s)
  Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
- Journal Title
  
  Mol pharmacol
  
  Volume: 91 Issue: 3 Pages: 159-166
- DOI
  10.1124/mol.116.105569
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17H03979
[Journal Article] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2017
- Author(s)
  Shibata Norihito、Miyamoto Naoki、Nagai Katsunori、Shimokawa Kenichiro、Sameshima Tomoya、Ohoka Nobumichi、Hattori Takayuki、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 8 Pages: 1657-1666
- DOI
  10.1111/cas.13284
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
[Journal Article] In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).2017
- Author(s)
  Ohoka, N., Okuhira, K., Ito, M., Nagai, K., Shibata, N., Hattori, T., Ujikawa, O., Shimokawa, K., Sano, O., Koyama, R., Fujita, H., Teratani, M., Matsumoto, H., Imaeda, Y., Nara, H., Cho, N. & Naito, M.
- Journal Title
  
  J Biol Chem
  
  Volume: 292 Issue: 11 Pages: 4556-4570
- DOI
  10.1074/jbc.m116.768853
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K08236
[Journal Article] Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation2017
- Author(s)
  Shimokawa Kenichiro、Shibata Norihito、Sameshima Tomoya、Miyamoto Naoki、Ujikawa Osamu、Nara Hiroshi、Ohoka Nobumichi、Hattori Takayuki、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 8 Issue: 10 Pages: 1042-1047
- DOI
  10.1021/acsmedchemlett.7b00247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
[Journal Article] Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands2017
- Author(s)
  Shibata Norihito、Nagai Katsunori、Morita Yoko、Ujikawa Osamu、Ohoka Nobumichi、Hattori Takayuki、Koyama Ryokichi、Sano Osamu、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 61 Issue: 2 Pages: 543-575
- DOI
  10.1021/acs.jmedchem.7b00168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
[Journal Article] Development of a peptide-based inducer of nuclear receptors degradation.2016
- Author(s)
  Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, Naito M, Kurihara M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 26 Issue: 11 Pages: 2655-2658
- DOI
  10.1016/j.bmcl.2016.04.013
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
[Journal Article] Induction of proteasomal degradation of ERα and subsequent cell death in breast cancer cells2016
- Author(s)
  K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 1366 Pages: 549-560
- DOI
  10.1007/978-1-4939-3127-9_42
- ISBN
  9781493931262, 9781493931279
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-16H05090
[Journal Article] Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.2016
- Author(s)
  Ohoka N, Shibata N, Hattori T, Naito M.
- Journal Title
  
  Current Cancer Drug Targets
  
  Volume: 16 Issue: 2 Pages: 136-146
- DOI
  10.2174/1568009616666151112122502
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050
[Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.2016
- Author(s)
  Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 26 Issue: 20 Pages: 4865-4869
- DOI
  10.1016/j.bmcl.2016.09.041
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916
[Journal Article] Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton2015
- Author(s)
  Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, Mikihiko Naito, Masaaki Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 22 Pages: 5362-5366
- DOI
  10.1016/j.bmcl.2015.09.030
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-26860049
[Journal Article] Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin proteasome pathway.2014
- Author(s)
  1.Ohoka, N., Nagai, K., Hattori, T., Okuhira, K., Shibata, N., Cho, N. and Naito, M
- Journal Title
  
  Cell Death Dis.
  
  Volume: 5 Issue: 11 Pages: e1513-e1513
- DOI
  10.1038/cddis.2014.471
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26860049
[Journal Article] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.2013
- Author(s)
  Okuhira, K., Demizu, Y., Hattori, T., Ohoka, N., Shibata, N., Nishimaki-Mogami, T., Okuda, H., Kurihara, M., Natiro, M.
- Journal Title
  
  Cancer Science
  
  Volume: 104 Issue: 11 Pages: 1492-1498
- DOI
  10.1111/cas.12272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790117, KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084
[Journal Article] HNF4α Increases Liver-Specific Human ATP-Binding Cassette Transporter A1 Expression and Cholesterol Efflux to Apolipoprotein A-I in Response to Cholesterol Depletion.2012
- Author(s)
  Ohoka N, Okuhira K, Cui H, Wu W, Sato R, Naito M, Nishimaki-Mogami T.
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: 32 Pages: 1005-1014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790117
[Journal Article] HNF4αIncreases Liver-Specific Human ATP-Binding Cassette Transporter A1 Expression and Cholesterol Efflux to Apolipoprotein A-I in Response to Cholesterol Depletion2012
- Author(s)
  Ohoka N, Okuhira K, Cui H, Wu W, Sato R, Naito N, and Nishimaki-Mogami T
- Journal Title
  
  Arterioscler. Thromb. Vasc. Biol
  
  Volume: 32 Issue: 4 Pages: 1005-1014
- DOI
  10.1161/atvbaha.111.238360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19108002, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23790117
[Journal Article] Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.2011
- Author(s)
  Okuhira K, Ohoka N, Sai K, Nishimaki-Mogami T, Itoh Y, Ishikawa M, Hashimoto Y, Naito M.
- Journal Title
  
  FEBS Lett.
  
  Volume: 585 Pages: 1147-1152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790117
[Patent] 複素環化合物2016
- Inventor(s)
  内藤幹彦, 大岡伸通, 柴田識人, 奥平桂一郎, 他12名
- Industrial Property Rights Holder
  内藤幹彦, 大岡伸通, 柴田識人, 奥平桂一郎, 他12名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-196803
- Filing Date
  2016-10-04
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] タンパク分解医薬の安全性確保に向けた新規オフターゲット評価法の開発2024
- Author(s)
  大岡伸通，山本武範，吉田徳幸，井上貴雄
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] 光分解リンカーを有するPROTACの開発2024
- Author(s)
  許涵喬，横尾英知，大岡伸通，井上貴雄，出水庸介
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] UBRタンパク質リガンドを活用した新規PROTACの開発2024
- Author(s)
  髙野玲奈，横尾英知，大岡伸通，大金賢司，井上貴雄，出水庸介
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] PROTACの開発に利用する新規E3リガーゼリガンドの構造活性相関研究2024
- Author(s)
  古内志拓，横尾英知，内藤幹彦，井上貴雄，大岡伸通，出水庸介
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] PROTACへの応用を志向した新たなE3リガンドの探索2023
- Author(s)
  高野玲奈, 横尾英知, 大岡伸通, 大金賢司, 井上貴雄, 出水庸介
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] PROTACに利用可能な新規E3リガンドの探索2023
- Author(s)
  髙野玲奈，横尾英知, 大岡伸通，大金賢司，井上貴雄，出水庸介
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] IAPリガンドとしてLCL161を有する、腫瘍形成融合タンパク質FGFR3-TACC3標的SNIPERの創出2023
- Author(s)
  長展生, 大岡伸通, 内藤幹彦
- Organizer
  第27回日本がん分子標的治療癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] エストロゲン受容体を標的とした核酸アプタマー型PROTACの創製2023
- Author(s)
  渡邊大嗣，永沼美弥子，辻厳一郎，大岡伸通，井上貴雄，内藤幹彦，出水庸介
- Organizer
  第49回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] 標的タンパク質の範囲拡大を目的とした核酸アプタマー型分解誘導剤の開発2023
- Author(s)
  辻厳一郎, 辻村はるな, 永沼美弥子, 大岡伸通, 井上貴雄, 内藤幹彦, 出水庸介
- Organizer
  第21回次世代を担う有機化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] リスク分子にフォーカスしたプロテオミクス応用型オフターゲット評価法の確立2023
- Author(s)
  大岡伸通，山本武範，吉田徳幸，井上貴雄
- Organizer
  第17回メタボロームシンポジウム
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] 標的タンパク質拡大を志向したオリゴ核酸型PROTACの創製2023
- Author(s)
  永沼美弥子，大岡伸通，辻厳一郎，内藤幹彦，井上貴雄，出水庸介
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] DNAアプタマーを利用したエストロゲン受容体を分解するPROTACの開発2023
- Author(s)
  大岡伸通, 内藤幹彦
- Organizer
  第84回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] 安定性の向上を志向したデコイ核酸型PROTACの開発2023
- Author(s)
  永沼美弥子, 大岡伸通, 内藤幹彦, 出水庸介
- Organizer
  第27回日本がん分子標的治療癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] タンパク質分解医薬のオフターゲット作用に関する種特異性の検証2022
- Author(s)
  大岡伸通, 山本武範, 築茂由則, 吉田徳幸, 井上貴雄
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] デコイ核酸を利用したキメラ分子による標的タンパク質分解2022
- Author(s)
  大岡伸通, 内藤幹彦, 出水庸介
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] デコイ核酸をリガンドに利用したエストロゲン受容体分解キメラ分子の開発2022
- Author(s)
  大岡伸通, 内藤幹彦
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] BRAF遺伝子変異陽性がんに対するBRAFタンパク質分解誘導薬の開発2022
- Author(s)
  大岡伸通, 内田琢也, 鈴木正則, 築茂由則,井上貴雄, 吉田将之, 大木仁, 内藤幹彦
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] BRAF遺伝子変異陽性がんに対するBRAFタンパク質分解誘導薬の開発2022
- Author(s)
  大岡伸通, 内田琢也, 鈴木正則, 築茂由則,井上貴雄, 吉田将之, 大木仁, 内藤幹彦
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] デコイ核酸を利用したタンパク質分解誘導キメラ分子の開発2021
- Author(s)
  大岡伸通，永沼美弥子，辻厳一郎，井上貴雄，出水庸介
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] デコイ核酸を利用したタンパク質分解誘導キメラ分子の開発2021
- Author(s)
  大岡伸通，永沼美弥子，辻厳一郎，井上貴雄，出水庸介
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] BRAF遺伝子変異陽性がんに対するBRAF分解誘導キメラ化合物の開発2021
- Author(s)
  大岡伸通, 築茂由則, 内藤幹彦
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] BRAF遺伝子変異陽性がんに対するBRAF分解誘導キメラ化合物の開発,2021
- Author(s)
  大岡伸通, 築茂由則, 内藤幹彦
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] BRAF遺伝子変異陽性がんに対するBRAF分解誘導キメラ化合物の開発2021
- Author(s)
  大岡伸通, 築茂由則, 井上貴雄, 内藤幹彦
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06490
[Presentation] BRAF遺伝子変異陽性がんに対するBRAF分解誘導キメラ化合物の開発2021
- Author(s)
  大岡伸通, 築茂由則, 井上貴雄, 内藤幹彦
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] 非天然型アミノ酸を有するヘリカルペプチドを利用したタンパク質分解誘導キメラ分子の開発2020
- Author(s)
  大岡伸通，横尾英知，内藤幹彦，井上貴雄，出水庸介
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] 1.Targeted protein degradation by chimeric small molecules that recruit new E3 ligase.2020
- Author(s)
  大岡伸通, 内藤幹彦
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] 急性骨髄性白血病に対するFLT3分解誘導キメラ化合物の開発2020
- Author(s)
  大岡伸通, 内藤幹彦
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] ペプチドリガンドを利用したタンパク質分解誘導キメラ分子の開発2020
- Author(s)
  大岡伸通, 横尾英知, 井上貴雄, 出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] 核内受容体を標的とするペプチド型分解誘導剤の開発2020
- Author(s)
  伊藤貴仁，横尾英知，大岡伸通，内藤幹彦，井上貴雄，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] LXRを標的とした分解誘導剤の開発2020
- Author(s)
  許涵喬，辻厳一郎，大岡伸通，内藤幹彦，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] Development of chimeric compounds to induce FLT3 degradation for acute myeloid leukemia.2020
- Author(s)
  大岡伸通, 柴田識人, 築茂由則, 内藤幹彦
- Organizer
  第79回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] デコイ核酸をリガンドとしたエストロゲン受容体分解誘導剤の創製2020
- Author(s)
  永沼美弥子，辻村はるな，大岡伸通，松野研司，須原義智，内藤幹彦，井上貴雄，辻厳一郎，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] アプタマーをリガンドとしたエストロゲン受容体分解誘導剤の創製2020
- Author(s)
  辻村はるな，永沼美弥子，大岡伸通，須原義智，松野研司，内藤幹彦，井上貴雄，辻厳一郎，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] Development of small molecule chimeras that recruit aryl-hydrocarbon receptor (AhR) E3 ligase to induce degradation of target proteins2019
- Author(s)
  Ohoka N, Tsuji G, Shoda T, Fujisato T, Kurihara M, Demizu Y, Naito M.
- Organizer
  AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] 新しいユビキチンリガーゼを標的蛋白質にリクルートして分解する低分子化合物の開発2019
- Author(s)
  大岡伸通, 内藤幹彦
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] 新しい創薬パラダイム-狙ったタンパク質を特異的に分解する低分子薬の開発-2019
- Author(s)
  大岡伸通
- Organizer
  化学フェスタ
- Invited
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] 新たなユビキチンリガーゼを利用して標的タンパク質を分解するキメラ化合物の開発2019
- Author(s)
  大岡伸通
- Organizer
  第2回ユビキチン研究会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] 新しいユビキチンリガーゼをリクルートして標的蛋白質を分解するキメラ化合物の開発と抗がん剤としての可能性2019
- Author(s)
  大岡伸通, 内藤幹彦
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] 新たなユビキチンリガーゼを標的タンパク質にリクルートして分解するキメラ化合物の開発2019
- Author(s)
  大岡伸通, 辻厳一郎, 正田卓司, 出水庸介, 内藤幹彦
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] 芳香族炭化水素受容体ユビキチンリガーゼを利用する新しいプロテインノックダウン技術の開発2018
- Author(s)
  大岡伸通, 辻厳一郎, 正田卓司, 藤里卓磨, 出水庸介, 内藤幹彦
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] SNIPERのIAPリガンド誘導体化によるプロテインノックダウン活性及び抗がん活性の改善2018
- Author(s)
  大岡伸通, 服部隆行, 内藤幹彦
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] SNIPERのIAPリガンド誘導体化によるプロテインノックダウン活性及び抗がん活性の改善2018
- Author(s)
  大岡伸通, 服部隆行, 内藤幹彦
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K06567
[Presentation] プロテインノックダウン法を利用したアンドロゲン受容体蛋白質分解誘導剤の開発2017
- Author(s)
  柴田識人、大岡伸通、服部隆行、永井克典、伊東昌宏、奈良洋、長展生、内藤幹彦
- Organizer
  日本薬学会第136年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] IAPを利用したプロテインノックダウン法の開発とがん原性タンパク質の分解2017
- Author(s)
  内藤幹彦、大岡伸通、柴田識人、服部隆行
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] IAPアンタゴニストLCL161誘導体を導入したSNIPERによる効果的なプロテインノックダウン2017
- Author(s)
  大岡伸通、奥平桂一郎、伊東昌宏、永井克典、柴田識人、服部隆行、宇治川治、下川賢一郎、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] Targeting the allosteric site of oncogenic BCR-ABL protein as an alternative strategy for effective protein degradation2017
- Author(s)
  Norihito Shibata, Kenichiro Shimokawa, Tomoya Sameshima, Naoki Miyamoto, Osamu Ujikawa, Hiroshi Nara, Nobumichi Ohoka, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] Degradation of target proteins by SNIPER compounds recruiting IAP ubiquitin ligases2017
- Author(s)
  Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
- Organizer
  EMBO conference　Ubiquitin and SUMO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017
- Author(s)
  大岡伸通、柴田識人、服部隆行、内藤幹彦
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] Degradation of oncogenic proteins by SNIPER compounds.2017
- Author(s)
  Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2017
- Author(s)
  大岡伸通、永井克典、奥平桂一郎、柴田識人、服部隆行、長展生、内藤幹彦
- Organizer
  日本薬学会第136年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] In vivo protein knockdown by chimeric small-compound SNIPERs.2017
- Author(s)
  Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, Kenichiro Shimokawa, Osamu Ujikawa, Ikuo Fujimori, Masahiro Ito, Youji Hayase, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Tomoya Samejima, Osamu Sano, Ryokichi Koyama, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2017
- Author(s)
  Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, Kenichiro Shimokawa, Tomoya Sameshima, Nobumichi Ohoka, Takayuki Hattori, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016
- Author(s)
  大岡伸通, 奥平桂一郎, 服部隆行, 内藤幹彦
- Organizer
  第20回日本がん分子標的治療学会
- Place of Presentation
  大分
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] Development of hybrid small molecules that induce degradation of oncogenic BCR-ABL2016
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜国際会議場（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] 低分子化合物SNIPERによる細胞内ユビキチン化機構の制御と創薬への応用2016
- Author(s)
  大岡伸通, 奥平桂一郎, 永井克典, 伊東昌宏, 柴田識人, 服部隆行, 宇治川治, 佐野修, 小山亮吉, 今枝泰宏, 奈良洋, 長展生, 内藤幹彦
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016
- Author(s)
  大岡伸通、奥平桂一郎、柴田識人、服部隆行、内藤幹彦
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016
- Author(s)
  大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜国際会議場（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016
- Author(s)
  大岡伸通, 柴田識人, 服部隆行, 内藤幹彦
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2016
- Author(s)
  大岡伸通, 伊東昌宏, 奥平桂一郎, 永井克典, 柴田識人, 服部隆行, 長展生, 内藤幹彦
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] ユビキチン化誘導剤によるユビキチン関連死の解明2015
- Author(s)
  大岡伸通, 永井克典, 柴田識人, 服部隆行, 長展生, 内藤幹彦
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会　合同大会）
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] Ubiquitin-related cancer cell death induced by small molecules degrading TACC3 protein.2015
- Author(s)
  大岡伸通, 柴田識人, 服部隆行, 内藤幹彦
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] TACC3分解誘導剤によるがん細胞のユビキチン関連死2015
- Author(s)
  大岡伸通, 服部隆行, 内藤幹彦
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] Apollonは細胞分裂初期においてスピンドルチェックポイント非依存的なcyclin Aの分解を促進する2014
- Author(s)
  大岡伸通,大畑広和,内藤幹彦
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-08
- Data Source
  KAKENHI-PROJECT-23790117
[Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2014
- Author(s)
  大岡伸通,大畑広和,内藤幹彦
- Organizer
  キーストンシンポジウム「ユビキチンシステム」
- Place of Presentation
  米国ビッグスカイ
- Year and Date
  2014-01-09
- Data Source
  KAKENHI-PROJECT-23790117
[Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2013
- Author(s)
  大岡伸通,大畑広和,内藤幹彦
- Organizer
  Ninth AACR-Japanese Cancer Association Joint Conference : Breakthroughs in Basic and Translational Cancer Research
- Place of Presentation
  米国マウイ
- Year and Date
  2013-02-22
- Data Source
  KAKENHI-PROJECT-23790117
[Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2013
- Author(s)
  大岡伸通,大畑広和,内藤幹彦
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23790117
[Presentation] ヒト肝癌細胞株におけるTRB3によるSREBP-2制御機構の解明2012
- Author(s)
  大岡伸通,林秀敏,内藤幹彦,佐藤隆一郎
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23790117
[Presentation] ヒト肝癌細胞株におけるTRB3によるSREBP-2制御機構の解明2011
- Author(s)
  大岡伸通,林秀敏,内藤幹彦,佐藤隆一郎
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23790117
[Presentation] ヒト肝癌細胞株におけるTRB3によるSREBP-2制御機構の解明2011
- Author(s)
  大岡伸通，林　秀敏，内藤幹彦, 佐藤　隆一郎
- Organizer
  第34回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23790117
[Presentation] ヒト肝癌細胞株におけるTRB3によるSREBP-2制御機構の解明2011
- Author(s)
  大岡伸通,林秀敏,内藤幹彦,佐藤隆一郎
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23790117
[Presentation] Apollonは細胞分裂初期においてスピンドルチェックポイント非依存的なcyclin Aの分解を促進する.
- Author(s)
  大岡伸通、大畑広和、内藤幹彦
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790117
[Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint.
- Author(s)
  大岡伸通、大畑広和、内藤幹彦
- Organizer
  キーストンシンポジウム「ユビキチンシステム」
- Place of Presentation
  米国ビッグスカイ
- Data Source
  KAKENHI-PROJECT-23790117
[Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint
- Author(s)
  大岡伸通, 大畑広和, 内藤幹彦
- Organizer
  Ninth AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research
- Place of Presentation
  Maui, HI, USA
- Data Source
  KAKENHI-PROJECT-23790117
[Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤によるがん細胞死の誘導.
- Author(s)
  大岡伸通, 奥平桂一郎, 柴田識人, 服部隆行, 内藤幹彦
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤による癌細胞死の誘導.
- Author(s)
  大岡伸通, 永井克典, 奥平桂一郎, 柴田識人, 服部隆行, 長展生, 内藤幹彦
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint.
- Author(s)
  大岡伸通、大畑広和、内藤幹彦
- Organizer
  第72回　日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790117
[Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤の開発と抗がん活性評価.
- Author(s)
  大岡伸通, 永井克典, 服部隆行,奥平桂一郎, 柴田識人,長展生, 内藤幹彦
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] SNIPER(TACC3) degrades TACC3 protein via the ubiquitin-proteasome pathway and induces apoptosis in cancer cells expressing a large amount of TACC3.
- Author(s)
  大岡伸通, 永井克典, 奥平桂一郎, 柴田識人, 服部隆行, 長展生, 内藤幹彦
- Organizer
  26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-11-18 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-26860049
[]

1. Naito Mikihiko (00198011)

# of Collaborated Projects: 2 results

# of Collaborated Products: 34 results
2. DEMIZU Yosuke (90389180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. KITTAKA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 服部隆行

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
5. 栗原正明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 奥平桂一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 佐藤隆一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohoka Nobumichi 大岡 伸通

OHOKA Nobumichi 大岡 伸通

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Co-Researchers

新規E3リガーゼを利用した標的タンパク質分解手法の基盤構築と安全性評価Principal Investigator

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がん特異的に発現するE3リガーゼを利用したプロテインノックダウン法の基盤構築Principal Investigator

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Development of small molecule chimeras that recruit a new E3 ligase to target proteinsPrincipal Investigator

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Design of peptide ligands based on protein-protein interaction and their application to protein knockdown technology

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Development of novel small molecules degrading microtubule-associated proteinsPrincipal Investigator

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Analysis of the molecular mechanism of ER stress regulation by a giant ubiquitin ligase, ApollonPrincipal Investigator

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[Book] 実験医学2020年9月号, キメラ化合物PROTAC/SNIPERの作用機序と新たな開発の動向2020

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[Book] 実験医学増刊, 標的タンパク質を分解する新しい低分子医薬モダリティ2020

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[Book] 実験医学2018年11月号（Next Tech Review）2018

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[Journal Article] Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins.2024

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[Journal Article] Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation.2024

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[Journal Article] Development of STING degrader with double covalent ligands.2024

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[Journal Article] Structural Optimization of Decoy Oligonucleotide-Based PROTAC That Degrades the Estrogen Receptor.2023

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[Journal Article] Development of DNA Aptamer-Based PROTACs That Degrade the Estrogen Receptor.2023

Ohoka Nobumichi 大岡伸通

OHOKA Nobumichi 大岡伸通