OHKAWARA Bisei 大河原美静

Researcher Number	80589606
Other IDs	https://orcid.org/0000-0002-1987-458X
Affiliation (based on the past Project Information) *help	2021 – 2023: 名古屋大学, 医学系研究科, 特任准教授 2017 – 2021: 名古屋大学, 医学系研究科, 准教授 2016: 名古屋大学, 高等研究院(医), 特任講師(専任講師クラス) 2015: 名古屋大学, 大学高等研究院, 特任講師 2012 – 2015: 名古屋大学, 高等研究院, 特任講師 2012 – 2013: 名古屋大学, 高等研究院(医), 特任講師 2011: 名古屋大学, 医学(系)研究科(研究院), 特任助教
Review Section/Research Field	Principal Investigator Basic Section 46010:Neuroscience-general-related / Neurophysiology / General neuroscience / Living organism molecular science Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 56020:Orthopedics-related / Basic Section 46030:Function of nervous system-related / Nerve anatomy/Neuropathology / Orthopaedic surgery / Pathological medical chemistry / Neurology
Keywords	Principal Investigator 神経筋接合部 / Ccnファミリー因子 / CTGF / 運動機能テスト / 細胞外マトリックス / 細胞外分泌因子 / シナプス形成 / 筋肉細胞 / 運動神経細胞 / 増殖因子 … More / シグナル伝達経路 / Wntシグナル伝達経路 / H2O2 / H2ガス / Wntシグナル / 分子状水素 / 過酸化水素 … More Except Principal Investigator 神経筋接合部 / 先天性筋無力症候群 / 先天性筋無力症行群 / GFPT1 / アセチルコリン受容体 / MuSK / Wnt / LRP4 / スプライシング / iPS細胞 / DOK7 / 変形性関節症 / Drug repositioning / CD44断片化抑制 / Wnt/βカテニン抑制 / 創薬 / 薬物療法 / サルコペニア / 再生医学 / 神経科学 / 細胞・組織 / iPS / MuSKリン酸化 / 運動神経 / 形成 / 脊髄 / Fgf18 / fibroblast growth factor / ColQ / LGR5 / RSPO2 Less

Investigation of the molecular formations and the pathomechanisms of the neuromuscular junction
- Principal Investigator
  
  大野欽司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University of Arts and Sciences
  Nagoya University
成体の神経筋接合部シナプスの維持におけるCcnファミリー因子の役割Principal Investigator
- Principal Investigator
  
  大河原美静
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Nagoya University
Pathological analysis of limb girdle congenital myasthenia and development of new therapy
- Principal Investigator
  
  Ito Mikako
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Nagoya University
Elucidation of molecular mechanisms of neuromuscular junction formations in physiology and pathology
- Principal Investigator
  
  Ohno Kinji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University
Development of a new therapeutic drug for osteoarthritis that has a cartilage-protecting effect by inhibiting Wnt/ADAM10
- Principal Investigator
  
  ISHIGURO Naoki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Nagoya University
Identification of secreted proteins in neuromuscular junctionPrincipal Investigator
- Principal Investigator
  
  Ohkawara Bisei
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Nagoya University
神経筋接合部の機能改善を標的としたサルコペニア治療薬の探索
- Principal Investigator
  
  石井久雄
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Nagoya University
Pathological analysis of GFPT1 congenital myasthenia and development of new therapy using iPS cells.
- Principal Investigator
  
  Ito Mikako
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Nagoya University
The roles of growth factors in neuromuscular junctionPrincipal Investigator
- Principal Investigator
  
  Ohkawara Bisei
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Nagoya University
Role of Fgf18 for neuromuscular junction
- Principal Investigator
  
  ITO KENYU
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagoya University
Molecular dissection of LPR4, a molecule expressed at the neuromuscular junction
- Principal Investigator
  
  KINJI Ohno
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagoya University
Molecular bases and their regulations of mRNA aberrations in neuromuscular transmission defects and other muscular diseases
- Principal Investigator
  
  OHNO Kinji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Molecular mechanism of H2O2 and H2 on Wnt signaling pathwayPrincipal Investigator
- Principal Investigator
  
  OHKAWARA Bisei
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Nagoya University

[Book] Molecular Genetics of Congenital Myasthenic Syndromes2014
- Author(s)
  Ohno K, Ohkawara B, Ito M, Engel AG
- Publisher
  eLS. John Wiley & Sons, Inc., Hoboken(in press)
- Data Source
  KAKENHI-PROJECT-25670164
[Book] Molecular Genetics of Congenital Myasthenic Syndromes. in eLS. DOI: 10.1002/9780470015902.a0024314)2014
- Author(s)
  Ohno K, Ohkawara B, Ito M, Engel AG.
- Publisher
  John Wiley & Sons, Inc., Hoboken, Chichester
- DOI
  10.1002/9780470015902.a0024314
- Data Source
  KAKENHI-PROJECT-24390221
[Book] Japanese Scientists in Science 2013 サイエンス誌に載った日本人研究者2014
- Author(s)
  Ohkawara Bisei, Cristina-Maria Cruciat, Christine Dolde, and Christof Niehrs
- Publisher
  American Association for the Advancement of Science (AAAS)
- Data Source
  KAKENHI-PROJECT-23710253
[Book] "Molecular Genetics of Congenital Myasthenic Syndromes" in eLS2014
- Author(s)
  Ohno K, Ohkawara B, Ito M, Engel AG.
- Publisher
  John Wiley & Sons, Inc., Hoboken
- Data Source
  KAKENHI-PROJECT-25670164
[Book] "Molecular Genetics of Congenital Myasthenic Syndromes" in eLS2014
- Author(s)
  Ohno K, Ohkawara B, Ito M, Engel AG.
- Publisher
  John Wiley & Sons, Inc., Hoboken
- Data Source
  KAKENHI-PROJECT-24390221
[Journal Article] Calcitriol ameliorates motor deficits and prolongs survival of Chrne-deficient mouse, a model for congenital myasthenic syndrome, by inducing Rspo22024
- Author(s)
  Ohkawara Bisei、Tomita Hiroyuki、Inoue Taro、Zhang Shaochuan、Kanbara Shunsuke、Koshimizu Hiroyuki、Miyasaka Yuki、Takeda Jun-ichi、Nishiwaki Hiroshi、Nakashima Hiroaki、Ito Mikako、Masuda Akio、Ishiguro Naoki、Ogi Tomoo、Ohno Tamio、Imagama Shiro、Ohno Kinji
- Journal Title
  
  Neurotherapeutics
  
  Volume: 21 Issue: 2 Pages: e00318-e00318
- DOI
  10.1016/j.neurot.2024.e00318
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06412, KAKENHI-PROJECT-20K06925, KAKENHI-PROJECT-21H04815
[Journal Article] Clinical and Pathologic Features of Congenital Myasthenic Syndromes Caused by 35 Genes?A Comprehensive Review2023
- Author(s)
  Ohno Kinji、Ohkawara Bisei、Shen Xin-Ming、Selcen Duygu、Engel Andrew G.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 4 Pages: 3730-3730
- DOI
  10.3390/ijms24043730
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06392, KAKENHI-PROJECT-21H04815, KAKENHI-PROJECT-20H03561
[Journal Article] Splicing regulation of GFPT1 muscle-specific isoform and its roles in glucose metabolisms and neuromuscular junction2023
- Author(s)
  Farshadyeganeh Paniz、Nazim Mohammad、Zhang Ruchen、Ohkawara Bisei、Nakajima Kazuki、Rahman Mohammad Alinoor、Nasrin Farhana、Ito Mikako、Takeda Jun-ichi、Ohe Kenji、Miyasaka Yuki、Ohno Tamio、Masuda Akio、Ohno Kinji
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 10 Pages: 107746-107746
- DOI
  10.1016/j.isci.2023.107746
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19269, KAKENHI-PROJECT-23K06412, KAKENHI-PROJECT-20K06925, KAKENHI-PROJECT-21K08266, KAKENHI-PROJECT-23K21309, KAKENHI-PROJECT-21H04815, KAKENHI-PROJECT-23K27485
[Journal Article] Activated FGFR3 suppresses bone regeneration and bone mineralization in an ovariectomized mouse model2023
- Author(s)
  Kawashima Itaru、Matsushita Masaki、Mishima Kenichi、Kamiya Yasunari、Osawa Yusuke、Ohkawara Bisei、Ohno Kinji、Kitoh Hiroshi、Imagama Shiro
- Journal Title
  
  BMC Musculoskeletal Disorders
  
  Volume: 24 Issue: 1 Pages: 200-200
- DOI
  10.1186/s12891-023-06318-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09646, KAKENHI-PROJECT-20K09477, KAKENHI-PROJECT-22K09398, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-21H03063, KAKENHI-PROJECT-21K06392
[Journal Article] Neural Isoforms of Agrin Are Generated by Reduced PTBP1-RNA Interaction Network Spanning the Neuron-Specific Splicing Regions in AGRN2023
- Author(s)
  Bushra Samira、Lin Ying-Ni、Joudaki Atefeh、Ito Mikako、Ohkawara Bisei、Ohno Kinji、Masuda Akio
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 8 Pages: 7420-7420
- DOI
  10.3390/ijms24087420
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-22K19269, KAKENHI-PROJECT-23K06412, KAKENHI-PROJECT-20K06925, KAKENHI-PROJECT-21K06392, KAKENHI-PROJECT-23K21309, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H04815, KAKENHI-PROJECT-23K27485
[Journal Article] Promethazine Downregulates Wnt/β-Catenin Signaling and Increases the Biomechanical Forces of the Injured Achilles Tendon in the Early Stage of Healing2022
- Author(s)
  Sakaguchi Takefumi、Ohkawara Bisei、Kishimoto Yasuzumi、Miyamoto Kentaro、Ishizuka Shinya、Hiraiwa Hideki、Ishiguro Naoki、Imagama Shiro、Ohno Kinji
- Journal Title
  
  The American Journal of Sports Medicine
  
  Volume: 50 Issue: 5 Pages: 1317-1327
- DOI
  10.1177/03635465221077116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06392, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-21H04815
[Journal Article] Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase2022
- Author(s)
  Koike Hiroshi、Nishida Yoshihiro、Shinomura Tamayuki、Ohkawara Bisei、Ohno Kinji、Zhuo Lisheng、Kimata Koji、Ushida Takahiro、Imagama Shiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 8 Pages: 4089-4089
- DOI
  10.3390/ijms23084089
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-21K06392, KAKENHI-PROJECT-20K18060, KAKENHI-PROJECT-22K16740, KAKENHI-PROJECT-21H04815, KAKENHI-PROJECT-20H03561
[Journal Article] Meclozine ameliorates bone mineralization and growth plate structure in a mouse model of X-linked hypophosphatemia2022
- Author(s)
  Kamiya Yasunari、Matsushita Masaki、Mishima Kenichi、Ohkawara Bisei、Michigami Toshimi、Imagama Shiro、Ohno Kinji、Kitoh Hiroshi
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 25 Issue: 1 Pages: 39-39
- DOI
  10.3892/etm.2022.11738
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09646, KAKENHI-PROJECT-20K09477, KAKENHI-PROJECT-22K09398, KAKENHI-PROJECT-21H04815, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-21H03063
[Journal Article] Efficacy of auranofin as an inhibitor of desmoid progression2022
- Author(s)
  Ito Kan、Nishida Yoshihiro、Hamada Shunsuke、Shimizu Koki、Sakai Tomohisa、Ohkawara Bisei、Alman Benjamin A.、Enomoto Atsushi、Ikuta Kunihiro、Koike Hiroshi、Zhang Jiarui、Ohno Kinji、Imagama Shiro
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 11918-11918
- DOI
  10.1038/s41598-022-15756-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09321, KAKENHI-PROJECT-19K16769, KAKENHI-PROJECT-20K18060, KAKENHI-PROJECT-22K16740, KAKENHI-PROJECT-21H04815, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-20K16328, KAKENHI-PROJECT-17H01585
[Journal Article] A mutation in DOK7 in congenital myasthenic syndrome forms aggresome in cultured cells, and reduces DOK7 expression and MuSK phosphorylation in patient-derived iPS cells2022
- Author(s)
  Zhang Shaochuan、Ohkawara Bisei、Ito Mikako、Huang Zhizhou、Zhao Fei、Nakata Tomohiko、Takeuchi Tomoya、Sakurai Hidetoshi、Komaki Hirofumi、Kamon Masayoshi、Araki Toshiyuki、Ohno Kinji
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 32 Issue: 9 Pages: 1511-1523
- DOI
  10.1093/hmg/ddac306
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06392, KAKENHI-PROJECT-21H04815, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-19K09565, KAKENHI-PROJECT-23K06412, KAKENHI-PROJECT-20K06925, KAKENHI-PROJECT-23K27485
[Journal Article] Meclozine ameliorates skeletal muscle pathology and increases muscle forces in mdx mice2022
- Author(s)
  Kawamura Yusuke、Hida Tetsuro、Ohkawara Bisei、Matsushita Masaki、Kobayashi Takeshi、Ishizuka Shinya、Hiraiwa Hideki、Tanaka Satoshi、Tsushima Mikito、Nakashima Hiroaki、Ito Kenyu、Imagama Shiro、Ito Mikako、Masuda Akio、Ishiguro Naoki、Ohno Kinji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 592 Pages: 87-92
- DOI
  10.1016/j.bbrc.2022.01.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-18K06483, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-21K06149, KAKENHI-PROJECT-21K06392, KAKENHI-PROJECT-22K19269, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-21H04815, KAKENHI-PROJECT-23K21309
[Journal Article] Regulated splicing of large exons is linked to phase‐separation of vertebrate transcription factors2021
- Author(s)
  Kawachi Toshihiko、Masuda Akio、Yamashita Yoshihiro、Takeda Jun‐ichi、Ohkawara Bisei、Ito Mikako、Ohno Kinji
- Journal Title
  
  The EMBO Journal
  
  Volume: 40 Issue: 22
- DOI
  10.15252/embj.2020107485
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-18K06483, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-20K06925, KAKENHI-PROJECT-21K06392, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-21H04815, KAKENHI-PROJECT-20H03561
[Journal Article] Screening of signaling pathways for agrin-induced AChR clustering in C2C12 myotubes2021
- Author(s)
  Noto K, Ohkawara B, Ishii H, Ito M, Masuda A, Hirata H, Ohno K.
- Journal Title
  
  Genes Cells
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03561
[Journal Article] Secreted Signaling Molecules at the Neuromuscular Junction in Physiology and Pathology2021
- Author(s)
  Ohkawara Bisei、Ito Mikako、Ohno Kinji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 5 Pages: 2455-2455
- DOI
  10.3390/ijms22052455
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06483, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-20H03561
[Journal Article] Zonisamide upregulates neuregulin-1 expression and enhances acetylcholine receptor clustering at the in vitro neuromuscular junction2021
- Author(s)
  Inoue Taro、Ohkawara Bisei、Bushra Samira、Kanbara Shunsuke、Nakashima Hiroaki、Koshimizu Hiroyuki、Tomita Hiroyuki、Ito Mikako、Masuda Akio、Ishiguro Naoki、Imagama Shiro、Ohno Kinji
- Journal Title
  
  Neuropharmacology
  
  Volume: 195 Pages: 108637-108637
- DOI
  10.1016/j.neuropharm.2021.108637
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-18K06483, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-21K06392, KAKENHI-PROJECT-21H04815, KAKENHI-PROJECT-20H03561
[Journal Article] Congenital myasthenic syndrome?associated agrin variants affect clustering of acetylcholine receptors in a domain-specific manner2020
- Author(s)
  Ohkawara Bisei、Shen XinMing、Selcen Duygu、Nazim Mohammad、Bril Vera、Tarnopolsky Mark A.、Brady Lauren、Fukami Sae、Amato Anthony A.、Yis Uluc、Ohno Kinji、Engel Andrew G.
- Journal Title
  
  JCI Insight
  
  Volume: 5 Issue: 7
- DOI
  10.1172/jci.insight.132023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06483, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-20H03561
[Journal Article] tRIP-seq Reveals Repression of Premature Polyadenylation by Co-Transcriptional FUS-U1 snRNP Assembly2020
- Author(s)
  Akio Masuda, Toshihiko Kawachi, Jun-Ichi Takeda, Bisei Ohkawara, Mikako Ito, Kinji Ohno
- Journal Title
  
  EMBO Rep.
  
  Volume: - Issue: 5
- DOI
  10.15252/embr.201949890
- NAID
  120006884959
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07094, KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-18K06483, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-20K06925, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-18K14684
[Journal Article] Gene Expression Profile at the Motor Endplate of the Neuromuscular Junction of Fast-Twitch Muscle2020
- Author(s)
  Huang Kun、Li Jin、Ito Mikako、Takeda Jun-Ichi、Ohkawara Bisei、Ogi Tomoo、Masuda Akio、Ohno Kinji
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 13 Pages: 154-154
- DOI
  10.3389/fnmol.2020.00154
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-18K06483, KAKENHI-PROJECT-20K06925, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-17K07094, KAKENHI-PROJECT-18K14684
[Journal Article] Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells.2020
- Author(s)
  Huang K, Masuda A, Chen G, Bushra S, Kamon M, Araki T, Kinoshita M, Ohkawara B, Ito M, Ohno K
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 2558-2558
- DOI
  10.1038/s41598-020-59517-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-19K09565, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-17K07094
[Journal Article] Zonisamide ameliorates progression of cervical spondylotic myelopathy in a rat model2020
- Author(s)
  Kanbara Shunsuke、Ohkawara Bisei、Nakashima Hiroaki、Ohta Kyotaro、Koshimizu Hiroyuki、Inoue Taro、Tomita Hiroyuki、Ito Mikako、Masuda Akio、Ishiguro Naoki、Imagama Shiro、Ohno Kinji
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 13138-13138
- DOI
  10.1038/s41598-020-70068-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06483, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-20H03561
[Journal Article] CTGF/CCN2 facilitates LRP4‐mediated formation of the embryonic neuromuscular junction2020
- Author(s)
  Ohkawara Bisei、Kobayakawa Akinori、Kanbara Shunsuke、Hattori Takako、Kubota Satoshi、Ito Mikako、Masuda Akio、Takigawa Masaharu、Lyons Karen M、Ishiguro Naoki、Ohno Kinji
- Journal Title
  
  EMBO reports
  
  Volume: 21 Issue: 8
- DOI
  10.15252/embr.201948462
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-18K06483, KAKENHI-PROJECT-19K10150, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-19K22716
[Journal Article] Author Correction: Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis2020
- Author(s)
  Okura Toshiaki、Ohkawara Bisei、Takegami Yasuhiko、Ito Mikako、Masuda Akio、Seki Taisuke、Ishiguro Naoki、Ohno Kinji
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 2995-2995
- DOI
  10.1038/s41598-020-60112-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-17K07094, KAKENHI-PROJECT-18K09062
[Journal Article] Zonisamide ameliorates neuropathic pain partly by suppressing microglial activation in the spinal cord in a mouse model2020
- Author(s)
  Koshimizu Hiroyuki、Ohkawara Bisei、Nakashima Hiroaki、Ota Kyotaro、Kanbara Shunsuke、Inoue Taro、Tomita Hiroyuki、Sayo Akira、Kiryu-Seo Sumiko、Konishi Hiroyuki、Ito Mikako、Masuda Akio、Ishiguro Naoki、Imagama Shiro、Kiyama Hiroshi、Ohno Kinji
- Journal Title
  
  Life Sciences
  
  Volume: 263 Pages: 118577-118577
- DOI
  10.1016/j.lfs.2020.118577
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06483, KAKENHI-PROJECT-19K06904, KAKENHI-PROJECT-20K06925, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-19K24067, KAKENHI-PROJECT-18H02524, KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-17K07094
[Journal Article] Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis2019
- Author(s)
  Okura Toshiaki、Ohkawara Bisei、Takegami Yasuhiko、Ito Mikako、Masuda Akio、Seki Taisuke、Ishiguro Naoki、Ohno Kinji
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 2808-2808
- DOI
  10.1038/s41598-019-39393-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-18K09062, KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15K06755
[Journal Article] Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction2018
- Author(s)
  Li Jin、Ito Mikako、Ohkawara Bisei、Masuda Akio、Ohno Kinji
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 13577-13577
- DOI
  10.1038/s41598-018-31949-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07094, KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15K06755
[Journal Article] Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters2018
- Author(s)
  Ito Kenyu、Ohkawara Bisei、Yagi Hideki、Nakashima Hiroaki、Tsushima Mikito、Ota Kyotaro、Konishi Hiroyuki、Masuda Akio、Imagama Shiro、Kiyama Hiroshi、Ishiguro Naoki、Ohno Kinji
- Journal Title
  
  Sceintific Reports
  
  Volume: 8 Issue: 1 Pages: 434-434
- DOI
  10.1038/s41598-017-18753-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-16K07055, KAKENHI-PROJECT-17K16688, KAKENHI-PROJECT-15H04840, KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-16H05446, KAKENHI-PROJECT-15K06755
[Journal Article] SRSF1 suppresses selection of intron-distal 5′ splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein2017
- Author(s)
  Ahsan Khalid Bin、Masuda Akio、Rahman Mohammad Alinoor、Takeda Jun-ichi、Nazim Mohammad、Ohkawara Bisei、Ito Mikako、Ohno Kinji
- Journal Title
  
  Sceintific Reports
  
  Volume: 7 Issue: 1 Pages: 10446-10446
- DOI
  10.1038/s41598-017-11036-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15K06755, KAKENHI-PROJECT-15H04840
[Journal Article] SRSF1 suppresses selection of intron-distal 5' splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein.2017
- Author(s)
  Ahsan KB, Masuda A, Rahman MA, Takeda JI, Nazim M, Ohkawara, Ito M, Ohno K
- Journal Title
  
  Sci Rep.
  
  Volume: 7 (1) Pages: 10446-10446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07094
[Journal Article] Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling2017
- Author(s)
  Miyamoto Kentaro、Ohkawara Bisei、Ito Mikako、Masuda Akio、Hirakawa Akihiro、Sakai Tadahiro、Hiraiwa Hideki、Hamada Takashi、Ishiguro Naoki、Ohno Kinji
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 9 Pages: e0184388-e0184388
- DOI
  10.1371/journal.pone.0184388
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15H04840, KAKENHI-PROJECT-16K15661
[Journal Article] Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders2017
- Author(s)
  Ohno Kinji、Ohkawara Bisei、Ito Mikako
- Journal Title
  
  Expert Opin Ther Targets.
  
  Volume: 21 Issue: 10 Pages: 949-958
- DOI
  10.1080/14728222.2017.1369960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15H04840
[Journal Article] Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms2017
- Author(s)
  Nazim M, Masuda A, Rahman MA, Nasrin F, Takeda JI, Ohe K, Ohkawara B, Ito M, Ohno K.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: - Pages: 1455-1468
- DOI
  10.1093/nar/gkw823
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04840, KAKENHI-PROJECT-25430049, KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15K10050, KAKENHI-PROJECT-15K06755
[Journal Article] Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis2017
- Author(s)
  Osawa Yusuke、Matsushita Masaki、Hasegawa Sachi、Esaki Ryusaku、Fujio Masahito、Ohkawara Bisei、Ishiguro Naoki、Ohno Kinji、Kitoh Hiroshi
- Journal Title
  
  Bone
  
  Volume: 105 Pages: 42-49
- DOI
  10.1016/j.bone.2017.05.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-16K10854, KAKENHI-PROJECT-16H05446, KAKENHI-PROJECT-17H04312, KAKENHI-PROJECT-15K10439, KAKENHI-PROJECT-15K15548
[Journal Article] Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells2017
- Author(s)
  Kishimoto Yasuzumi、Ohkawara Bisei、Sakai Tadahiro、Ito Mikako、Masuda Akio、Ishiguro Naoki、Shukunami Chisa、Docheva Denitsa、Ohno Kinji
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 7 Pages: e0182051-e0182051
- DOI
  10.1371/journal.pone.0182051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15H04840
[Journal Article] R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5.2016
- Author(s)
  Nakashima H., Ohkawara B., Ishigaki S., Fukudome T., Ito K., Tsushima M., Konishi H., Okuno T., Yoshimura T., Ito M., Masuda A., Sobue G., Kiyama H., Ishiguro N., Ohno K.
- Journal Title
  
  Sci Rep
  
  Volume: 22 Issue: 1 Pages: 28512-28512
- DOI
  10.1038/srep28512
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15H04840, KAKENHI-PROJECT-25430049, KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15K06755, KAKENHI-PROJECT-15K09310, KAKENHI-PROJECT-16K07055, KAKENHI-ORGANIZER-26117001
[Journal Article] R-spondin 2 facilitates differentiation of proliferating chondrocytes into hypertrophic chondrocytes by enhancing Wnt/β-catenin signaling in endochondral ossification.2016
- Author(s)
  Takegami Y, Ohkawara B, Ito M, Masuda A, Nakashima H, Ishiguro N, Ohno K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: S0006-291X(16) Issue: 1 Pages: 30400-4
- DOI
  10.1016/j.bbrc.2016.03.089
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-25430049, KAKENHI-PROJECT-15K06755
[Journal Article] Molecular hydrogen suppresses activated Wnt-catenin signaling.2016
- Author(s)
  Y. Lin, B. Ohkawara, M. Ito, N. Misawa, K. Miyamoto, Y. Takegami, A. Masuda, S. Toyokuni, K Ohno
- Journal Title
  
  Scientific Report
  
  Volume: 25 Issue: 1 Pages: 31986-31986
- DOI
  10.1038/srep31986
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24108008, KAKENHI-PROJECT-15H04840, KAKENHI-PROJECT-25430049, KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15K06755
[Journal Article] Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy2016
- Author(s)
  1.Chen G, Masuda A, Konishi H, Ohkawara B, Ito M, Kinoshita M, Kiyama H, Matsuura T, Ohno K.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 25317-25317
- DOI
  10.1038/srep25317
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04840, KAKENHI-PROJECT-26670170, KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15K06755, KAKENHI-PROJECT-16K07055
[Journal Article] Impaired Synaptic Development, Maintenance, and Neuromuscular Transmission in LRP4-Related Myasthenia.2015
- Author(s)
  Selcen D, Ohkawara B, Shen XM, McEvoy K, Ohno K, Engel AG.
- Journal Title
  
  JAMA Neurol.
  
  Volume: 72(8) Issue: 8 Pages: 889-96
- DOI
  10.1001/jamaneurol.2015.0853
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15H04840
[Journal Article] Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling.2015
- Author(s)
  Otsuka K, Ito M, Ohkawara B, Masuda A, Kawakami Y, Sahashi K, Nishida H, Mabuchi N, Takano A, Engel AG, Ohno K.
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Issue: 1 Pages: 13928-13928
- DOI
  10.1038/srep13928
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-25430049, KAKENHI-PROJECT-15H04840, KAKENHI-PROJECT-24500469
[Journal Article] Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model.2015
- Author(s)
  Yagi H, Ohkawara B, Nakashima H, Ito K, Tsushima M, Ishii H, Noto K, Ohta K, Masuda A, Imagama S, Ishiguro N, Ohno K.
- Journal Title
  
  PLoS One.
  
  Volume: 10(11) Issue: 11 Pages: e0142786-e0142786
- DOI
  10.1371/journal.pone.0142786
- NAID
  120005946839
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06707
[Journal Article] Congenital myasthenic syndrome in Japan: ethnically unique mutations in muscle nicotinic acetylcholine receptor subunits2015
- Author(s)
  Azuma Y, Nakata T, Tanaka M, Shen XM, Ito M, Iwata S, Okuno T, Nomura Y, Ando N, Ishigaki K, Ohkawara B, Masuda A, Natsume J, Kojima S, Sokabe M, Ohno K.
- Journal Title
  
  Neuromuscul Disord
  
  Volume: 25(1) Issue: 1 Pages: 60-69
- DOI
  10.1016/j.nmd.2014.09.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390221, KAKENHI-PROJECT-25430049, KAKENHI-PROJECT-24247028
[Journal Article] Position-specific binding of FUS to nascent RNA regulates mRNA length.2015
- Author(s)
  Masuda A, Takeda J, Okuno T, Okamoto T, Ohkawara B, Ito M, Ishigaki S, Sobue G, Ohno K.
- Journal Title
  
  Genes Dev.
  
  Volume: 29(10) Issue: 10 Pages: 1045-57
- DOI
  10.1101/gad.255737.114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15K06755, KAKENHI-PROJECT-15K09310, KAKENHI-PROJECT-25430049, KAKENHI-PUBLICLY-25118508, KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15H04840, KAKENHI-PROJECT-24500469
[Journal Article] A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space.2015
- Author(s)
  Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K.
- Journal Title
  
  Neuromuscul Disord.
  
  Volume: 25(8) Issue: 8 Pages: 667-71
- DOI
  10.1016/j.nmd.2015.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06707, KAKENHI-PROJECT-15K09326, KAKENHI-PROJECT-25430049, KAKENHI-PROJECT-15H04840, KAKENHI-PROJECT-24500469
[Journal Article] Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.2014
- Author(s)
  Takamatsu, A., Ohkawara, B., Ito, M., Masuda, A., Sakai, T., Ishiguro, N. and Ohno, K.
- Journal Title
  
  PLOS ONE
  
  Volume: 9(3) Issue: 3 Pages: e92699-e92699
- DOI
  10.1371/journal.pone.0092699
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23700422, KAKENHI-PROJECT-23710253, KAKENHI-PROJECT-24500469, KAKENHI-PROJECT-24659672, KAKENHI-PROJECT-25430049
[Journal Article] LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner2014
- Author(s)
  Ohkawara B, Cabrera-Serrano M, Nakata T, Milone M, Asai N, Ito K, Ito M, Masuda A, Ito Y, Engel AG, Ohno K
- Journal Title
  
  Hum Mol Genet.
  
  Volume: Apr 1;23(7) Issue: 7 Pages: 1856-68
- DOI
  10.1093/hmg/ddt578
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23710253, KAKENHI-PROJECT-24390221, KAKENHI-PROJECT-24500469, KAKENHI-PUBLICLY-25118508, KAKENHI-PROJECT-25430049, KAKENHI-PROJECT-25670164, KAKENHI-PROJECT-15H04840
[Journal Article] RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling2013
- Author(s)
  Cruciat CM, Dolde C, de Groot RE, Ohkawara B, Reinhard C, Korswagen HC, Niehrs C.
- Journal Title
  
  Science
  
  Volume: 339(6126) Pages: 1436-1441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710253
[Journal Article] RNA helicase DDX3 is regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling2013
- Author(s)
  Cruciat CM, Dolde C, de Groot RE, Ohkawara B, Reinhard C, Korswagen HC, Niehrs C
- Journal Title
  
  Science
  
  Volume: Mar22; 339(6126) Issue: 6126 Pages: 1436-41
- DOI
  10.1126/science.1231499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710253
[Journal Article] Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia.2013
- Author(s)
  Matsushita, M., Kitoh, H., Ohkawara, B., Mishima, K., Kaneko, H., Ito, M., Masuda, A., Ishiguro, N. and Ohno, K.
- Journal Title
  
  PLOS ONE
  
  Volume: 8(12) Issue: 12 Pages: 81569-81569
- DOI
  10.1371/journal.pone.0081569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700422, KAKENHI-PROJECT-23710253, KAKENHI-PROJECT-24249076, KAKENHI-PROJECT-24500469, KAKENHI-PROJECT-24592230, KAKENHI-PROJECT-24592259, KAKENHI-PROJECT-24659671, KAKENHI-PROJECT-25430049
[Journal Article] Anti-MuSK autoantibodies block binding of collagen Q to MuSK.2011
- Author(s)
  Kawakami Y, Ito M, Hirayama M, Sahashi K, Ohkawara B, Masuda A, Nishida H, Mabuchi N, Engel AG, Ohno K.
- Journal Title
  
  Neurology
  
  Volume: 77(20) Issue: 20 Pages: 1819-1826
- DOI
  10.1212/wnl.0b013e318237f660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710253
[Journal Article] An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopusembryos2011
- Author(s)
  Ohkawara B, Niehrs C.
- Journal Title
  
  Dev Dyn
  
  Volume: Jan; 240(1) Issue: 1 Pages: 188-94
- DOI
  10.1002/dvdy.22500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710253
[Patent] Ｒ－スポンジン２によるＷｎｔ／βーカテニン2018
- Inventor(s)
  大河原美静、大野欽司、大倉俊昭、石黒直樹
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-15K06707
[Patent] 末梢神経障害治療薬2015
- Inventor(s)
  大野　欽司、石黒　直樹、大河原　美静、八木　秀樹
- Industrial Property Rights Holder
  国立大学法人名古屋大学、大日本住友製薬
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-193291
- Filing Date
  2015-09-30
- Data Source
  KAKENHI-PROJECT-15K06707
[Presentation] Single-nucleus RNA-seq identifies transcriptional regulation of embryonic neuromuscular junction in skeletal muscle2022
- Author(s)
  Bisei Ohkawara
- Organizer
  55th Annual Meeting of the Japanese Society of Developmental Biologists
- Data Source
  KAKENHI-PROJECT-21K06392
[Presentation] Interactions between muscle glucose homeostasis and neuromuscular signal transduction - Lessons learned from lack of a muscle-specific long isoform of GFPT1 -2022
- Author(s)
  Farshadyeganeh P, Nazim M, Ohkawara B, Masuda A, Ito M, Takeda J, Ohe K, Ohno K.
- Organizer
  European Human Genetics Conference 2022 (Platform), Vienna, Austria
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03561
[Presentation] Functional analysis of mutations in a glycosylation enzyme gene, GFPT1, underlying limb-girdle congenital myasthenic syndromes (CMS)2021
- Author(s)
  Farshadyeganeh P, Ohkawara B, Kamon M, Araki T, Komaki H, Ohno K
- Organizer
  European Human Genetics Conference 2021 (Poster), Virtual Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03561
[Presentation] 神経筋接合部形成における細胞外分泌因子の役割2020
- Author(s)
  大河原美静
- Organizer
  第６回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06483
[Presentation] Activity of Wnt signaling in regenerated tendon and its effects on tendon repair.2020
- Author(s)
  Takefumi Sakaguchi, Bisei Ohkawara, Hideki Hiraiwa, Shinya Ishizuka, Kinji Ohno, Naoki Ishiguro
- Organizer
  ORS 2020 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03779
[Presentation] Promethazineは腱修復中の過剰なWntシグナルを抑制し、修復腱の力学的特性を改善した2020
- Author(s)
  坂口健史, 大河原美静, 増田章男, 伊藤美佳子, 武田淳一, 濱口知成, 今釜史郎, 平岩秀樹, 石塚真哉, 大野欽司
- Organizer
  第6回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03779
[Presentation] Meclozine enhances skeletal muscle growth and improves exercise performance.2019
- Author(s)
  Yusuke Kawamura, Bisei Ohkawara, Hideki Hiraiwa, Shinya Ishizuka, Kinji Ohno, Naoki Ishiguro
- Organizer
  第5回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03779
[Presentation] 腱再生におけるwntシグナル活性の変化とそれが腱修復に与える影響2019
- Author(s)
  坂口健史,大河原美静, 岸本烈純, 宮本健太郎, 平岩秀樹, 石黒直樹, 大野欽司
- Organizer
  第34 回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03779
[Presentation] Wnt/beta-catenin signaling in chondrocytes for cartilage degradation of osteoarthritis2018
- Author(s)
  大河原　美静
- Organizer
  分子生物学会ワークショップ
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06707
[Presentation] Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes2018
- Author(s)
  大河原　美静
- Organizer
  2018 Wnt meeting in Heidelberg
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06707
[Presentation] Wnt-related molecules at mammalian neuromuscular junction2017
- Author(s)
  Bisei Ohkawara
- Organizer
  Wnt Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06707
[Presentation] 経筋接合部の構成因子としてのCTGFの役割2016
- Author(s)
  大河原美静、大野欽司
- Organizer
  ＣＣＮファミリー研究会
- Place of Presentation
  岡山大学鹿田キャンパス内(岡山県岡山市)
- Data Source
  KAKENHI-PROJECT-15K06707
[Presentation] R-spondin2 is crucial for neuromuscular junction formation2013
- Author(s)
  中島宏彰、大河原美静、石黒直樹、大野欽司
- Organizer
  SFN2013(Society for Neuroscience Meeting)
- Place of Presentation
  アメリカ、サンディエゴ、サンディエゴコンベンションセンター
- Year and Date
  2013-11-13
- Data Source
  KAKENHI-PROJECT-23710253
[Presentation] R-spondin2 is crucial for neuromuscular junction formation2013
- Author(s)
  Nakashima H, Ohkawara B, Imagama S, Ito Z, Ishiguro N, Ohno K
- Organizer
  43rd Annual Meeting, Society for Neuroscience (Poster)
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-24390221
[Presentation] Mutations in LRP4 in congenital myasthenia reveal position-specific regulations of agrin and Wnt signaling of LRP42013
- Author(s)
  大河原美静、Macarena Cabrera-Serrano, 中田智彦, Margherita Milone, 浅井信之, 伊藤康友, Andrew G.Engel,　大野欽司
- Organizer
  Society of Neuroscience(北米神経科学学会)主催のNeuroscience2013
- Place of Presentation
  アメリカ、サンディエゴ、サンディエゴコンベンションセンター
- Data Source
  KAKENHI-PROJECT-23710253
[Presentation] Mutations in LRP4 in congenital myasthenia reveal position-specific regulations of agrin and Wnt signaling of LPR42013
- Author(s)
  Ohkawara B, Cabrera M, Nakata T, Shen X, Ito Y, Engel AG, Ohno K
- Organizer
  43rd Annual Meeting, Society for Neuroscience (Poster)
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-25670164
[Presentation] Mutations in the third β-propeller domain of LRP4 in congenital myasthenia compromise agrin-mediated MuSK signaling in a position-specific manner2013
- Author(s)
  Ohkawara B, Cabrera M, Nakata T, Milone M, Ito Y, Engel AG, Ohno K
- Organizer
  36th Annual Meeting of the Japan Neuroscience Society (Poster)
- Place of Presentation
  国立京都国際会館 (京都市 )
- Year and Date
  2013-06-22
- Data Source
  KAKENHI-PROJECT-25670164
[Presentation] Mutations in the third β-propeller domain of LRP4 in congenital myasthenia compromise agrin-mediated MuSK signaling in a position-specific manner2013
- Author(s)
  Ohkawara B, Cabrera M, Nakata T, Milone M, Ito Y, Engel AG, Ohno K
- Organizer
  36th Annual Meeting of the Japan Neuroscience Society (Poster)
- Place of Presentation
  国立京都国際会館(京都市)
- Data Source
  KAKENHI-PROJECT-24390221
[Presentation] Mutations in LRP4 in congenital myasthenia reveal position-specific regulations of agrin and Wnt signalingof LRP42013
- Author(s)
  大河原美静、Macarena Cabrera-Serrano, 中田智彦, Margherita Milone,浅井信之, 伊藤康友, Andrew G.Engel,大野欽司
- Organizer
  SFN2013 (Society for Neuroscience Meeting)
- Place of Presentation
  アメリカ、サンディエゴ、サンディエゴコンベンションセンター
- Year and Date
  2013-11-13
- Data Source
  KAKENHI-PROJECT-23710253
[Presentation] Mutations in LRP4 in congenital myasthenia reveal position-specific regulations of agrin and Wnt signaling of LPR42013
- Author(s)
  Ohkawara B, Cabrera M, Nakata T, Shen X, Ito Y, Engel AG, Ohno K
- Organizer
  43rd Annual Meeting, Society for Neuroscience (Poster)
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-24390221
[Presentation] R-spondin2 is crucial for neuromuscular junction formation2013
- Author(s)
  中島宏彰、大河原美静、石黒直樹、大野欽司
- Organizer
  Society of Neuroscience(北米神経科学学会)主催のNeuroscience2013
- Place of Presentation
  アメリカ、サンディエゴ、サンディエゴコンベンションセンター
- Data Source
  KAKENHI-PROJECT-23710253
[Presentation] Mutations in LRP4 in congenital myasthenia reveal position-specific regulations of agrin and Wnt signaling of LPR42013
- Author(s)
  Ohkawara B, Cabrera M, Nakata T, Shen X, Ito Y, Engel AG, Ohno K
- Organizer
  43rd Annual Meeting Society for Neuroscience (Poster)
- Place of Presentation
  San Diego, USA
- Year and Date
  2013-11-13
- Data Source
  KAKENHI-PROJECT-25670164
[Presentation] Mutations in the third β-propeller domain of LRP4 in congenital myasthenia compromise agrin-mediated MuSK signaling in a position-specific manner2013
- Author(s)
  Ohkawara B, Cabrera M, Nakata T, Milone M, Ito Y, Engel AG, Ohno K
- Organizer
  36th Annual Meeting of the Japan Neuroscience Society (Poster)
- Place of Presentation
  国立京都国際会館(京都市)
- Data Source
  KAKENHI-PROJECT-25670164
[Presentation] Functional characterization of GFPT1 during myogenesis and NMJ formation2012
- Author(s)
  Ohkawara B, Fuse Y, Nakashima H, Ohno K
- Organizer
  The 11th Annual Scientific Meeting of the Asian and Oceanian Myology Center (Poster)
- Place of Presentation
  京都市芝蘭会館（京都市）
- Data Source
  KAKENHI-PROJECT-24390221

1. OHNO Kinji (80397455)

# of Collaborated Projects: 5 results

# of Collaborated Products: 25 results
2. ITO Mikako (60444402)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
3. MASUDA Akio (10343203)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
4. ITO KENYU (10732638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ISHIGURO Naoki (20212871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 石井久雄 (30738349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 栗本秀 (70597856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 平田仁 (80173243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 高橋伸典 (20570196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 水野正明 (70283439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 平岩秀樹 (70566976)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. ITO kengo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. IKUTA Kunihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 祖父江元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 豊國伸哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 鬼頭浩史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 三島健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 松下雅樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 神谷庸成

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 小池宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 伊藤鑑

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 西田佳弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 酒井智久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHKAWARA Bisei 大河原 美静

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成体の神経筋接合部シナプスの維持におけるCcnファミリー因子の役割Principal Investigator

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Identification of secreted proteins in neuromuscular junctionPrincipal Investigator

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The roles of growth factors in neuromuscular junctionPrincipal Investigator

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Molecular mechanism of H2O2 and H2 on Wnt signaling pathwayPrincipal Investigator

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[Book] Molecular Genetics of Congenital Myasthenic Syndromes2014

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[Book] Molecular Genetics of Congenital Myasthenic Syndromes. in eLS. DOI: 10.1002/9780470015902.a0024314)2014

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Publisher

OHKAWARA Bisei 大河原美静