Nakamura Ryoichi 中村亮一

… Alternative Names

NAKAMURA Ryoichi 中村亮一

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Researcher Number	80723030
Other IDs
Affiliation (Current)	2025: 愛知医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 愛知医科大学, 医学部, 講師 2019 – 2020: 名古屋大学, 医学系研究科, 特任助教 2015 – 2018: 名古屋大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Neurology
Keywords	Principal Investigator 次世代シークエンサー / ALS / 筋萎縮性側索硬化症 / ACSL5 / THSD7A / FGF1 / VCP / 網羅的解析 / SOD1 / ターゲットリシークエンス … More / 遺伝子変異 / 網羅的遺伝子解析 / missing heritability / リピート伸長変異 / missing heritabbility / 構造多型 / LRP1 / ATXN3 / KIF5A / FTLD疾患関連遺伝子 / ALS疾患関連遺伝子 / 高次機能障害 / 筋萎縮性側策硬化症 / TBK1 / FTD / 前頭側頭葉変性症 / 高次脳機能障害 / 脳神経疾患 / 候補遺伝子 / ゲノム / 分子疫学 … More Except Principal Investigator 筋萎縮性側索硬化症 / タンパク質品質管理機構 / iPS細胞 / 運動ニューロン / ALS / 疾患レジストリ / 神経病理解析 / 治療薬探索 / 予後関連因子 / 予後因子 / 全ゲノム解析 / 自律神経障害 / 末梢神経障害 / 認知症 / DWI / 皮膚生検 / 白質脳症 / 核内封入体 Less

ALSにおける老化によるタンパク質品質管理機構の発現変化と病態への影響
- Principal Investigator
  
  藤内玄規
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Aichi Medical University
Elucidating the heterogeneity of amyotrophic lateral sclerosis by neuropathological analysis linked to clinical genomic information
- Principal Investigator
  
  熱田直樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Aichi Medical University
筋萎縮性側索硬化症のmissing heritabilityに関わる遺伝子の探索Principal Investigator
- Principal Investigator
  
  中村亮一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Aichi Medical University
候補遺伝子アプローチによる筋萎縮性側索硬化症病態関連遺伝子の探索Principal Investigator
- Principal Investigator
  
  中村亮一
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Aichi Medical University
  Nagoya University
Therapeutic development based on factors affecting progression and prognosis of amyotrophic lateral sclerosis
- Principal Investigator
  
  Atsuta Naoki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Analysis of genes affecting cognitive function in sporadic ALSPrincipal Investigator
- Principal Investigator
  
  Nakamura Ryoichi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Investigation of clinical picture and causative gene of NIID
- Principal Investigator
  
  Sone Jun
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Comprehensive genetic analysis of ALS-related genes in Japanese sporadic ALS patientsPrincipal Investigator
- Principal Investigator
  
  NAKAMURA Ryoichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] ALSFRS-R decline rate prior to baseline is not useful for stratifying subsequent progression of functional decline2024
- Author(s)
  Hamatani Tatsuto、Atsuta Naoki、Sano Fumiya、Nakamura Ryoichi、Hayashi Yukikazu、Sobue Gen
- Journal Title
  
  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  
  Volume: 25 Issue: 3-4 Pages: 388-399
- DOI
  10.1080/21678421.2024.2309989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-22K07359, KAKENHI-PROJECT-22K07509
[Journal Article] Nationwide survey of patients with multisystem proteinopathy in Japan2024
- Author(s)
  Yamashita Satoshi、Takahashi Yuji、Hashimoto Jun、Murakami Ayuka、Nakamura Ryoichi、Katsuno Masahisa、Izumi Rumiko、Suzuki Naoki、Warita Hitoshi、Aoki Masashi、the Japan MSP Study Group
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: - Issue: 4 Pages: 938-945
- DOI
  10.1002/acn3.52011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18260, KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-22K07509, KAKENHI-PROJECT-18K07491, KAKENHI-PROJECT-21K07411
[Journal Article] 多因子性神経難病の全ゲノム解析：筋萎縮性側索硬化症2023
- Author(s)
  中村亮一、熱田直樹、祖父江元
- Journal Title
  
  医学のあゆみ
  
  Volume: 285 Pages: 103-109
- Data Source
  KAKENHI-PROJECT-19K07973
[Journal Article] Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients2023
- Author(s)
  Nakamura R, Tohnai G, Nakatochi M,… Onodera K, Ito T, Okada Y, Okano H, Sobue G
- Journal Title
  
  Journal of Neurology, Neurosurgery & Psychiatry
  
  Volume: 94 Issue: 10 Pages: 816-824
- DOI
  10.1136/jnnp-2022-330851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15739, KAKENHI-PROJECT-19K06523, KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-22K07359, KAKENHI-PROJECT-22K07509, KAKENHI-PROJECT-23K06955, KAKENHI-PROJECT-23K06975, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-23K24249
[Journal Article] 多因子性神経難病の全ゲノム解析：筋萎縮性側索硬化症2023
- Author(s)
  中村亮一、熱田直樹、祖父江元
- Journal Title
  
  医学のあゆみ
  
  Volume: 285 Pages: 103-109
- Data Source
  KAKENHI-PROJECT-22K07509
[Journal Article] The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK2022
- Author(s)
  Yokoi S, Ito T, Sahashi K, Nakatochi M, Tohnai G, Nakamura R, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y*, Sobue G*
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 42 Issue: 47 Pages: 8881-8896
- DOI
  10.1523/jneurosci.0455-22.2022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-22K07509, KAKENHI-PROJECT-22K07515, KAKENHI-PROJECT-22K07545, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-21K15622, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-18K15470, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-23K24249, KAKENHI-PROJECT-23K21410
[Journal Article] 【神経疾患とゲノム医療】個別病態・疾患のゲノム医療　筋萎縮性側索硬化症2022
- Author(s)
  中村亮一, 熱田直樹, 祖父江元
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 40 Pages: 1138-1142
- Data Source
  KAKENHI-PROJECT-22K07509
[Journal Article] Clinical Features of Female Carriers and Prodromal Male Patients With Spinal and Bulbar Muscular Atrophy2022
- Author(s)
  Torii Ryota、Hashizume Atsushi、Yamada Shinichiro、Ito Daisuke、Kishimoto Yoshiyuki、Moriyoshi Hideyuki、Inagaki Tomonori、Nakamura Ryoichi、Nakamura Tomohiko、Naoi Tameto、Morita Mitsuya、Katsuno Masahisa
- Journal Title
  
  Neurology
  
  Volume: 100 Issue: 1
- DOI
  10.1212/wnl.0000000000201342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-21K07458, KAKENHI-PROJECT-22K07509
[Journal Article] Convenient Auditory-Based Language and Executive Function Test for Patients With Amyotrophic Lateral Sclerosis: A Pilot Study2022
- Author(s)
  Ohdake Reiko、Watanabe Hirohisa、Kawabata Kazuya、Ogura Aya、Sato Maki、Tanaka Yasuhiro、Imai Kazunori、Masuda Michihito、Kato Toshiyasu、Yokoi Takamasa、Hara Kazuhiro、Nakamura Ryoichi、Atsuta Naoki、Nakagawa Masafumi、Katsuno Masahisa、Sobue Gen
- Journal Title
  
  Archives of Clinical Neuropsychology
  
  Volume: 38 Issue: 1 Pages: 57-71
- DOI
  10.1093/arclin/acac069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-22K07359, KAKENHI-PROJECT-22K07509
[Journal Article] 【神経疾患とゲノム医療】個別病態・疾患のゲノム医療　筋萎縮性側索硬化症2022
- Author(s)
  中村亮一, 熱田直樹, 祖父江元
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 40 Pages: 1138-1142
- Data Source
  KAKENHI-PROJECT-19K07973
[Journal Article] Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis2022
- Author(s)
  Tohnai Genki、Nakamura Ryoichi、Atsuta Naoki、(他29名) Sobue Gen
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 113 Pages: 131-136
- DOI
  10.1016/j.neurobiolaging.2021.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06523, KAKENHI-PROJECT-22K07359, KAKENHI-PROJECT-22K07509, KAKENHI-PROJECT-19K07973
[Journal Article] The SYNGAP1 3'UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK.2022
- Author(s)
  Yokoi S, Ito T, Sahashi K, Nakatochi M, Nakamura R, Tohnai G, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y, Sobue G.
- Journal Title
  
  J Neurosci.
  
  Volume: 42（47） Pages: 8881-8896
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07359
[Journal Article] Fiber‐specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis2021
- Author(s)
  Ogura Aya、Kawabata Kazuya、Watanabe Hirohisa、Choy Shao Wei、Bagarinao Epifanio、Kato Toshiyasu、Imai Kazunori、Masuda Michihito、Ohdake Reiko、Hara Kazuhiro、Nakamura Ryoichi、Atsuta Naoki、Nakamura Tomohiko、Katsuno Masahisa、Sobue Gen
- Journal Title
  
  European Journal of Neurology
  
  Volume: 29 Issue: 2 Pages: 432-440
- DOI
  10.1111/ene.15136
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04025, KAKENHI-PROJECT-19K07973
[Journal Article] The wide-ranging clinical and genetic features in Japanese families with valosin-containing protein proteinopathy2021
- Author(s)
  Ando T, Nakamura R, Kuru S, Yokoi D, Atsuta N, Koike H, Suzuki M, Hara K, Iguchi Y, Harada Y, Yoshida Y, Hattori M, Murakami A, Noda S, Kimura S, Sone J, Nakamura T, Goto Y, Mano K, Okada H, Okuda S, Nishino I, Ogi T, Sobue G, Katsuno M
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 100 Pages: 120.e1-120.e6
- DOI
  10.1016/j.neurobiolaging.2020.10.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-20H03589
[Journal Article] Genetic and functional analysis of KIF5A variants in Japanese patients with sporadic amyotrophic lateral sclerosis2021
- Author(s)
  Nakamura R, Tohnai G, Atsuta N, Nakatochi M, Hayashi N, Watanabe H, Yokoi D, Watanabe H, Katsuno M, Izumi Y, Taniguchi A, Kanai K, Morita M, Kano O, Kuwabara S, Oda M, Abe K, Aoki M, Aiba I, Okamoto K, Mizoguchi K, Hattori N, Nakashima K, Kaji R, Sobue G
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 97 Pages: 147.e11-147.e17
- DOI
  10.1016/j.neurobiolaging.2020.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07973
[Journal Article] Clinicoradiological features in amyotrophic lateral sclerosis patients with olfactory dysfunction2021
- Author(s)
  Masuda Michihito、Watanabe Hirohisa、Ogura Aya、Ohdake Reiko、Kato Toshiyasu、Kawabata Kazuya、Hara Kazuhiro、Nakamura Ryoichi、Atsuta Naoki、Epifanio Bagarinao、Katsuno Masahisa、Sobue Gen
- Journal Title
  
  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  
  Volume: 22 Issue: 3-4 Pages: 260-266
- DOI
  10.1080/21678421.2020.1859544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07973
[Journal Article] The neural network basis of altered decision‐making in patients with amyotrophic lateral sclerosis2020
- Author(s)
  Imai Kazunori、Masuda Michihito、Watanabe Hirohisa、Ogura Aya、Ohdake Reiko、Tanaka Yasuhiro、Kato Toshiyasu、Kawabata Kazuya、Riku Yuichi、Hara Kazuhiro、Nakamura Ryoichi、Atsuta Naoki、Bagarinao Epifanio、Katahira Kentaro、Ohira Hideki、Katsuno Masahisa、Sobue Gen
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 7 Issue: 11 Pages: 2115-2126
- DOI
  10.1002/acn3.51185
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KT0002, KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-19KK0062, KAKENHI-PROJECT-19H01201, KAKENHI-PROJECT-19H00524
[Journal Article] A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.2020
- Author(s)
  Nakamura R, Misawa K, Tohnai G, Nakatochi M, Furuhashi S, Atsuta N, Hayashi N, Yokoi D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Kanai K, Hattori N, Morita M, Taniguchi A, Kano O, Oda M, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Ohta Y, Yamashita T, Abe K, Hashimoto R, Aiba I, Okada Y, Nagasaki M, Sobue G. et al.,
- Journal Title
  
  Commun Biol.
  
  Volume: 23 Issue: 1 Pages: 526-526
- DOI
  10.1038/s42003-020-01251-2
- NAID
  120007178464
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-20K07754, KAKENHI-PROJECT-20K12157, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-17K10432, KAKENHI-PROJECT-18K07519
[Journal Article] Prognosis of amyotrophic lateral sclerosis patients undergoing tracheostomy invasive ventilation therapy in Japan2020
- Author(s)
  Hayashi Naoki、Atsuta Naoki、Yokoi Daichi、Nakamura Ryoichi、Nakatochi Masahiro、Katsuno Masahisa、Izumi Yuishin、Kanai Kazuaki、Hattori Nobutaka、Taniguchi Akira、Morita Mitsuya、Kano Osamu、Shibuya Kazumoto、Kuwabara Satoshi、Suzuki Naoki、Aoki Masashi、Aiba Ikuko、Mizoguchi Kouichi、Oda Masaya、Kaji Ryuji、Sobue Gen
- Journal Title
  
  Journal of Neurology, Neurosurgery & Psychiatry
  
  Volume: 91 Issue: 3 Pages: 285-290
- DOI
  10.1136/jnnp-2019-322213
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07519, KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-17K09778, KAKENHI-PROJECT-17K09811, KAKENHI-PROJECT-17K16110
[Journal Article] A nerve conduction study predicts the prognosis of sporadic amyotrophic lateral sclerosis2020
- Author(s)
  Imai Eriko、Nakamura Tomohiko、Atsuta Naoki、Nakatochi Masahiro、Suzuki Masashi、Harada Yumiko、Nakamura Ryoichi、Hayashi Naoki、Sobue Gen、Katsuno Masahisa
- Journal Title
  
  Journal of Neurology
  
  Volume: 267 Issue: 9 Pages: 2524-2532
- DOI
  10.1007/s00415-020-09858-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07973
[Journal Article] 増大特集 ALS2019 ALSにおける患者レジストリの役割-JaCALSなど2019
- Author(s)
  熱田直樹、中村亮一、林直毅、藤内玄規、勝野雅央、祖父江元
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 71 Issue: 11 Pages: 1215-1225
- DOI
  10.11477/mf.1416201431
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2019-11-01
- Data Source
  KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-17K09778
[Journal Article] Semantic deficits in ALS related to right lingual/fusiform gyrus network involvement2019
- Author(s)
  Ogura Aya、Watanabe Hirohisa、Kawabata Kazuya、Ohdake Reiko、Tanaka Yasuhiro、Masuda Michihito、Kato Toshiyasu、Imai Kazunori、Yokoi Takamasa、Hara Kazuhiro、Bagarinao Epifanio、Riku Yuichi、Nakamura Ryoichi、Kawai Yoshinari、Nakatochi Masahiro、Atsuta Naoki、Katsuno Masahisa、Sobue Gen
- Journal Title
  
  EBioMedicine
  
  Volume: 47 Pages: 506-517
- DOI
  10.1016/j.ebiom.2019.08.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-17K09778
[Journal Article] Multi-Ethnic Comparison of the Characteristics of Amyotrophic Lateral Sclerosis-Related TBK1 Gene Variants2019
- Author(s)
  Tohnai Genki、Nakamura Ryoichi、Nakatochi Masahiro、Atsuta Naoki、Katsuno Masahisa、Sobue Gen
- Journal Title
  
  Journal of Neurology & Neuromedicine
  
  Volume: 4 Issue: 1 Pages: 7-11
- DOI
  10.29245/2572.942x/2019/1.1236
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16116, KAKENHI-PROJECT-17K16118
[Journal Article] Increase of arginine dimethylation correlates with the progression and prognosis of ALS.2019
- Author(s)
  Ikenaka K, Atsuta N, Maeda Y, Hotta Y, Nakamura R, Kawai K, Yokoi D, Hirakawa A, Taniguchi A, Morita M, Mizoguchi K, Mochizuki H, Kimura K, Katsuno M, Sobue G.
- Journal Title
  
  Neurology.
  
  Volume: 92 Issue: 16
- DOI
  10.1212/wnl.0000000000007311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09778, KAKENHI-PROJECT-17K16116, KAKENHI-PROJECT-19K07973
[Journal Article] Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.2018
- Author(s)
  Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R, Akiyama T, Hadano S, Aoki M, Saya H, Sobue G, Okano H.
- Journal Title
  
  Nat Med.
  
  Volume: 24 Issue: 10 Pages: 1579-1589
- DOI
  10.1038/s41591-018-0140-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09778, KAKENHI-ORGANIZER-26117001, KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17K16116
[Journal Article] Frequency and characteristics of the TBK1 gene variants in Japanese patients with sporadic amyotrophic lateral sclerosis2018
- Author(s)
  Tohnai Genki、Nakamura Ryoichi、Sone Jun、Nakatochi Masahiro、Yokoi Daichi、Katsuno Masahisa、Watanabe Hazuki、Watanabe Hirohisa、Ito Mizuki、Li Yuanzhe、Izumi Yuishin、et al. Atsuta Naoki、Sobue Gen
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 64 Pages: 158.e15-158.e19
- DOI
  10.1016/j.neurobiolaging.2017.12.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09778, KAKENHI-PROJECT-17K16116, KAKENHI-PROJECT-17K16118, KAKENHI-ORGANIZER-26117001, KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-17J03762
[Journal Article] Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility2018
- Author(s)
  Tanikawa Chizu、Ueda Koji、Suzuki Akari、Iida Aritoshi、Nakamura Ryoichi、Atsuta Naoki、Tohnai Genki、Sobue Gen、Saichi Naomi、Momozawa Yukihide、Kamatani Yoichiro、Kubo Michiaki、Yamamoto Kazuhiko、Nakamura Yusuke、Matsuda Koichi
- Journal Title
  
  Cell Reports
  
  Volume: 22 Issue: 6 Pages: 1473-1483
- DOI
  10.1016/j.celrep.2018.01.031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0116, KAKENHI-PROJECT-16K08634, KAKENHI-PROJECT-17K09778, KAKENHI-PROJECT-17K16116, KAKENHI-PROJECT-26710007, KAKENHI-PUBLICLY-16H01566, KAKENHI-PROJECT-16H02676
[Journal Article] Age-related impairment in Addenbrooke's cognitive examination revised scores in patients with amyotrophic lateral sclerosis.2018
- Author(s)
  Masuda M, Watanabe H, Tanaka Y, Ohdake R, Ogura A, Yokoi T, Imai K, Kawabata K, Riku Y, Hara K, Nakamura R, Atsuta N, Katsuno M, Sobue G.
- Journal Title
  
  Amyotroph Lateral Scler Frontotemporal Degener.
  
  Volume: Epub ahead of print Issue: 7-8 Pages: 1-7
- DOI
  10.1080/21678421.2018.1510009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09778, KAKENHI-ORGANIZER-26117001, KAKENHI-PLANNED-26117002, KAKENHI-PROJECT-17K16116, KAKENHI-PROJECT-17K16117
[Journal Article] オミックス解析を通じて希少難治性疾患の医療に貢献する基盤研究　大規模臨床、ゲノム、不死化細胞リソースを基盤としたオミックス解析による孤発性ALS治療法開発2018
- Author(s)
  中村亮一, 熱田直樹, 祖父江元
- Journal Title
  
  遺伝子医学MOOK
  
  Volume: 34 Pages: 55-61
- Data Source
  KAKENHI-PROJECT-17K16116
[Journal Article] Reply: Neuronal intranuclear (hyaline) inclusion disease and fragile X-associated tremor/ataxia syndrome: a morphological and molecular dilemma2017
- Author(s)
  Sone Jun、Nakamura Tomohiko、Koike Haruki、Katsuno Masahisa、Tanaka Fumiaki、Iwasaki Yasushi、Yoshida Mari、Sobue Gen
- Journal Title
  
  BRAIN
  
  Volume: 140 Issue: 8 Pages: e52-e52
- DOI
  10.1093/brain/awx158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09312
[Journal Article] Structural MRI correlates of prognosis in amyotrophic lateral sclerosis2017
- Author(s)
  Joe Senda、Naoki Atsuta、Hirohisa Watanabe、Bagarinao Epifanio Jr、Kazunori Imai、Daichi Yokoi、Yuchi Riku、Michihito Masuda、Ryoichi Nakamura、Hazuki Watanabe、Mizuki Ito、Masahisa Katsuno、Shinji Naganawa、Gen Sobue
- Journal Title
  
  Journal of Neurology, Neurosurgery & Psychiatry
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19485
[Journal Article] Structural MRI correlates of amyotrophic lateral sclerosis progression2017
- Author(s)
  Senda Joe、Atsuta Naoki、Watanabe Hirohisa、Bagarinao Epifanio、Imai Kazunori、Yokoi Daichi、Riku Yuichi、Masuda Michihito、Nakamura Ryoichi、Watanabe Hazuki、Ito Mizuki、Katsuno Masahisa、Naganawa Shinji、Sobue Gen
- Journal Title
  
  Journal of Neurology, Neurosurgery & Psychiatry
  
  Volume: 88 Issue: 11 Pages: 901-907
- DOI
  10.1136/jnnp-2016-314337
- NAID
  120006375888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09778, KAKENHI-PROJECT-17K16116, KAKENHI-ORGANIZER-26117001, KAKENHI-PLANNED-26117002
[Journal Article] 【神経疾患のゲノム医療】筋萎縮性側索硬化症のゲノム医療2017
- Author(s)
  中村亮一, 藤内玄規, 熱田直樹, 勝野雅央, 祖父江元
- Journal Title
  
  神経内科
  
  Volume: 86 Pages: 678-685
- Data Source
  KAKENHI-PROJECT-17K16116
[Journal Article] Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum.2016
- Author(s)
  Masuda, M., Senda, J., Watanabe, H., Epifanio, B., Tanaka, Y., Imai, K., Riku, Y., Li, Y., Nakamura, R., Ito, M., Ishigaki, S., Atsuta, N., Koike, H., Katsuno, M., Hattori, N., Naganawa, S., and Sobue, G.
- Journal Title
  
  Amyotroph Lateral Scler Frontotemporal Degener
  
  Volume: 17 Issue: 7-8 Pages: 571-579
- DOI
  10.1080/21678421.2016.1211151
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117002, KAKENHI-PROJECT-25293263, KAKENHI-PROJECT-15K15338, KAKENHI-PROJECT-15K19485, KAKENHI-PROJECT-16K09700, KAKENHI-ORGANIZER-26117001
[Journal Article] A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN.2016
- Author(s)
  Watanabe H, Atsuta N, Hirakawa A, Nakamura R, Nakatochi M, Ishigaki S, Iida A, Sobue G.
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: in press Issue: 8 Pages: 851-8
- DOI
  10.1136/jnnp-2015-311541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09310, KAKENHI-PROJECT-26461319, KAKENHI-PROJECT-25461277, KAKENHI-PROJECT-26670439, KAKENHI-ORGANIZER-26117001, KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-15K15338, KAKENHI-PROJECT-15K19485
[Journal Article] Next-generation sequencing of 28 ALS-related genes in a Japanese ALS cohort2016
- Author(s)
  Ryoichi Nakamura, Jun Sone, Naoki Atsuta, Genki Tohnai, Hazuki Watanabe, Daichi Yokoi, Masahiro Nakatochi, Hirohisa Watanabe, Mizuki Ito, Jo Senda, Masahisa Katsuno, Fumiaki Tanaka, Yuanzhe Li, Yuishin Izumi, Mitsuya Morita, Akira Taniguchi, Osamu Kano, Masaya Oda, Satoshi Kuwabara, Koji Abe.
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 39 Pages: 219-219
- DOI
  10.1016/j.neurobiolaging.2015.11.030
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19485, KAKENHI-PROJECT-221S0002, KAKENHI-PROJECT-25461277, KAKENHI-PROJECT-15K15337, KAKENHI-PROJECT-26670439, KAKENHI-PROJECT-26670445, KAKENHI-PROJECT-25860725, KAKENHI-PROJECT-25293207, KAKENHI-ORGANIZER-26117001, KAKENHI-PROJECT-15H05667, KAKENHI-PROJECT-26461319
[Journal Article] Age of onset differentially influences the progression of regional dysfunction in sporadic amyotrophic lateral sclerosis2016
- Author(s)
  Daichi Yokoi、Naoki Atsuta、Hazuki Watanabe、Ryoichi Nakamura、Akihiro Hirakawa、Mizuki Ito、Hirohisa Watanabe、Masahisa Katsuno、Yuishin Izumi、Mitsuya Morita、Akira Taniguchi、Masaya Oda、Koji Abe、Kouichi Mizoguchi、Osamu Kano、Satoshi Kuwabara、Ryuji Kaji、Gen Sobue、JaCALS
- Journal Title
  
  Journal of Neurology
  
  Volume: 263 Issue: 6 Pages: 1129-1136
- DOI
  10.1007/s00415-016-8109-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19485
[Patent] ＡＬＳ患者の予後予測の検査方法、検査キット及び医薬のスクリーニング方法2020
- Inventor(s)
  祖父江元、中村亮一、藤内玄規、中杤昌弘、熱田直樹
- Industrial Property Rights Holder
  祖父江元、中村亮一、藤内玄規、中杤昌弘、熱田直樹
- Industrial Property Rights Type
  特許
- Patent Publication Number
  2021-180643
- Filing Date
  2020
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] ALSの早期診断：遺伝子診断2023
- Author(s)
  中村亮一、熱田直樹、藤内玄規、丹羽淳一、道勇学、祖父江元
- Organizer
  第64回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] ALSの早期診断：遺伝子診断2023
- Author(s)
  中村亮一、熱田直樹、藤内玄規、丹羽淳一、道勇学、祖父江元
- Organizer
  第64回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07509
[Presentation] Verification of genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis2023
- Author(s)
  Ryoichi Nakamura, Genki Tohnai, Masahiro Nakatochi, Naoki Atsuta, Hirohisa Watanabe, Daisuke Ito, Masahisa Katsuno, Yuishin Izumi, et al.
- Organizer
  PACTALS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07509
[Presentation] Development of Therapeutic Drugs Using iPS Cell-Derived Motor Neurons from ALS Patients2023
- Author(s)
  Genki Tohnai, Ryoichi Nakamura, Naoki Atsuta, Kazunari Onodera, Youhei Okada, Gen Sobue
- Organizer
  PACTALS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06835
[Presentation] Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients2023
- Author(s)
  Ryoichi Nakamura, Genki Tohnai, Masahiro Nakatochi, Naoki Atsuta, Daisuke Ito, Masahisa Katsuno, Yuishin Izumi, Mitsuya Morita, Takehisa Hirayama, Osamu Kano, et al.
- Organizer
  34th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07509
[Presentation] Clinicopathological and genetic characteristics of amyotrophic lateral sclerosis patients with SOD1-Gly93Ser mutation in Japan2023
- Author(s)
  Ryoichi Nakamura, Yuichi Riku, Masahiro Nakatochi, Naoki Atsuta, Genki Tohnai, Daisuke Ito, Yuishin Izumi, Rina Hashimoto, Ikuko Aiba, et al.
- Organizer
  PACTALS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] Verification of genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis2023
- Author(s)
  Ryoichi Nakamura, Genki Tohnai, Masahiro Nakatochi, Naoki Atsuta, Hirohisa Watanabe, Daisuke Ito, Masahisa Katsuno, Yuishin Izumi, et al.
- Organizer
  PACTALS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] Clinicopathological and genetic characteristics of amyotrophic lateral sclerosis patients with SOD1-Gly93Ser mutation in Japan2023
- Author(s)
  Ryoichi Nakamura, Yuichi Riku, Masahiro Nakatochi, Naoki Atsuta, Genki Tohnai, Daisuke Ito, Yuishin Izumi, Rina Hashimoto, Ikuko Aiba, et al.
- Organizer
  PACTALS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07509
[Presentation] 筋萎縮性側索硬化症の臨床遺伝学的研究2023
- Author(s)
  中村亮一
- Organizer
  日本人類遺伝学会第68回大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients2023
- Author(s)
  Ryoichi Nakamura, Genki Tohnai, Masahiro Nakatochi, Naoki Atsuta, Daisuke Ito, Masahisa Katsuno, Yuishin Izumi, Mitsuya Morita, Takehisa Hirayama, Osamu Kano, et al.
- Organizer
  34th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] 筋萎縮性側索硬化症の臨床遺伝学的研究2023
- Author(s)
  中村亮一
- Organizer
  日本人類遺伝学会第68回大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07509
[Presentation] Two novel variants in CHCHD2 associate with TDP-43 pathology among amyotrophic lateral sclerosis2022
- Author(s)
  Aya Ikeda, Manabu Funayama, Mari Yoshida, Yuanzhe Li, Tsuyoshi Inoshita , Kahori Shiba-fukushima, Hongrui Meng, Taku Amo, Ikuko Aiba, Yufuko Saito, Naoki Atsuta, Ryoichi Nakamura, Genki Tohnai, et al.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] SOD1-G93S変異陽性筋萎縮性側索硬化症患者の臨床遺伝学的特徴2022
- Author(s)
  中村亮一, 中杤昌弘, 熱田直樹, 藤内玄規, 伊藤大輔, 和泉唯信, 橋本里奈, 饗場郁子, 溝口功一, 金井数明, 青木正志, 柴田俊, 伊藤千弘, 湯淺知子, 徳井啓介, 川頭祐一, 丹羽淳一, 道勇学, 勝野雅央, 祖父江元
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07509
[Presentation] Two novel variants in CHCHD2 associate with TDP-43 pathology among amyotrophic lateral sclerosis2022
- Author(s)
  Aya Ikeda, Manabu Funayama, Mari Yoshida, Yuanzhe Li, Tsuyoshi Inoshita , Kahori Shiba-fukushima, Hongrui Meng, Taku Amo, Ikuko Aiba, Yufuko Saito, Naoki Atsuta, Ryoichi Nakamura, et al.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07509
[Presentation] SOD1-G93S変異陽性筋萎縮性側索硬化症患者の臨床遺伝学的特徴2022
- Author(s)
  中村亮一, 中杤昌弘, 熱田直樹, 藤内玄規, 伊藤大輔, 和泉唯信, 橋本里奈, 饗場郁子, 溝口功一, 金井数明, 青木正志, 柴田俊, 伊藤千弘, 湯淺知子, 徳井啓介, 川頭祐一, 丹羽淳一, 道勇学, 勝野雅央, 祖父江元
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] SOD1-G93S変異陽性筋萎縮性側索硬化症患者の臨床遺伝学的及び病理学的特徴2022
- Author(s)
  中村亮一、中杤昌弘、陸雄一、熱田直樹、藤内玄規、伊藤大輔、和泉　唯信、橋本里奈、饗場郁子、溝口功一、金井数明、青木正志、徳井啓介、川頭祐一、丹羽淳一、道勇学、岩崎靖、吉田眞理、勝野雅央、祖父江元
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] ALSに対するprecision medicineに向けて2022
- Author(s)
  熱田直樹, 中村亮一, 藤内玄規, 祖父江元
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] SOD1-G93S変異陽性筋萎縮性側索硬化症患者の臨床遺伝学的及び病理学的特徴2022
- Author(s)
  中村亮一、中杤昌弘、陸雄一、熱田直樹、藤内玄規、伊藤大輔、和泉　唯信、橋本里奈、饗場郁子、溝口功一、金井数明、青木正志、徳井啓介、川頭祐一、丹羽淳一、道勇学、岩崎靖、吉田眞理、勝野雅央、祖父江元
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-22K07509
[Presentation] ALSに対するprecision medicineに向けて2022
- Author(s)
  熱田直樹, 中村亮一, 藤内玄規, 祖父江元
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07509
[Presentation] Genetic analysis of KIF5A gene in Japanese patients with sporadic ALS.2021
- Author(s)
  Ryoichi Nakamura, Naoki Atsuta, Genki Tohnai, Masahiro Nakatochi, Naoki Hayashi, Masahisa Katsuno, Yuishin Izumi, Akira Taniguchi, Nobutaka Hattori, Mitsuya Morita, Osamu Kano, Satoshi Kuwabara, Masaya Oda, Koji Abe, Kouichi Mizoguchi, Ryuji Kaji, Jun-ichi Niwa, Manabu Doyu, Gen Sobue
- Organizer
  PACTALS 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] Genome-wide meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis2021
- Author(s)
  Ryoichi Nakamura, Kazuharu Misawa, Genki Tohnai, Masahiro Nakatochi, Naoki Atsuta, Naoki Hayashi, Masahisa Katsuno, Yuishin Izumi, Nobutaka Hattori, Mitsuya Morita, Akira Taniguchi, Osamu Kano, Masaya Oda, Satoshi Kuwabara, Ryuji Kaji, Jun-ichi Niwa, Manabu Doyu, Masao Nagasaki, Gen Sobue
- Organizer
  PACTALS 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] 発症13ヵ月で人工呼吸器管理を要し、SOD1遺伝子Ser134Asn変異を認めた筋萎縮性側索硬化症の1例2021
- Author(s)
  村尾厚徳, 辻河高陽, 小倉礼, 中村亮一, 勝野雅央
- Organizer
  第39回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] SynGAP variant from ALS cohort causes spine abnormality by excessive recruitment of FUS and hnRNPK2021
- Author(s)
  Yokoi Satoshi, Ito Takuji, Sahashi Kentaro, Nakamura Ryoichi, Ishigaki Shinsuke, Atsuta Naoki, Katsuno Masahisa, Okada Yohei, Sobue Gen
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] 錐体路徴候を伴う遺伝性軸索型運動ニューロパチーの一例2021
- Author(s)
  柴田俊, 伊藤千弘, 湯淺知子, 中村亮一, 徳井啓介, 川頭祐一, 丹羽淳一, 道勇学
- Organizer
  第161 回日本神経学会東海・北陸地方会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with ALS2021
- Author(s)
  Ryoichi Nakamura, Kazuharu Misawa, Genki Tohnai, Masahiro Nakatochi, Naoki Atsuta, Naoki Hayashi, Masahisa Katsuno, Yuishin Izumi, Nobutaka Hattori, Mitsuya Morita, Akira Taniguchi, Osamu Kano, Masaya Oda, Satoshi Kuwabara, Ryuji Kaji, Yukihide Momozawa, Masao Nagasaki, Gen Sobue
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] Two novel variants in CHCHD2 associate with TDP-43 pathology among amyotrophic lateral sclerosis2021
- Author(s)
  Ikeda Aya, Funayama Manabu, Yoshida Mari, Takanashi Masashi, Li Yuanzhe, Inoshita Tsuyoshi, Shiba-Fukushima Kahori, Meng Hongrui, Amo Taku, Aiba Ikuko, Saito Yufuko, Atsuta Naoki, Nakamura Ryoichi, et al.
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] 孤発性・家族性神経疾患のゲノム研究　ALSのゲノム研究2021
- Author(s)
  熱田直樹, 中村亮一, 藤内玄規, 祖父江元
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] 日本におけるSOD1遺伝子変異陽性筋萎縮性側索硬化症患者の臨床的特徴2020
- Author(s)
  中村亮一，熱田直樹，林直毅，藤内玄規，勝野雅央，和泉唯信，金井数明，服部信孝，谷口彰, 森田光哉, 狩野修, 澁谷和幹, 桑原聡, 鈴木直輝, 青木正志，阿部康二, 石原智彦, 小野寺理, 梶龍兒，祖父江元
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] 日本人孤発性筋萎縮性側索硬化症患者における KIF5A 遺伝子変異の頻度と特徴2020
- Author(s)
  中村亮一、藤内玄規、熱田直樹、中杤昌弘、林直毅、渡辺宏久、勝野雅央、和泉唯信、谷口彰、森田光哉、狩野修、桑原聡、織田雅也、阿部康二、青木正志、溝口功一、服部信孝、梶龍兒、祖父江元
- Organizer
  日本人類遺伝学会第65回大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] ビッグデータからみるALSの臨床像、遺伝子と治療開発の展望2020
- Author(s)
  熱田直樹, 中村亮一, 藤内玄規, 勝野雅央, 祖父江元
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] 封入体筋炎におけるエクソーム解析2019
- Author(s)
  勝野雅央、中村亮一、村上あゆ香、野田成哉、木村正剛、熱田直樹
- Organizer
  多系統蛋白質症(MSP)の疾患概念確立および診断基準作成、診療体制構築に関する研究班会議
- Data Source
  KAKENHI-PROJECT-17K16116
[Presentation] Genetics of ALS and related disorders2019
- Author(s)
  Ryoichi Nakamura
- Organizer
  The first joint symposium of the Neurological Institute of VGHTPE and Department Neurology of Nagoya University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16116
[Presentation] Mutation analysis of KIF5A in Japanese patients with amyotrophic lateral sclerosis2019
- Author(s)
  中村亮一、熱田直樹、藤内玄規、中杤昌弘、林直毅、渡辺宏久、勝野雅央、和泉唯信、谷口彰、服部信孝、森田光哉、狩野修、桑原聡、織田雅也、阿部康二、溝口功一、梶龍兒、祖父江元、JaCALS
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] Clinical and histopathological characteristics of MSP1 patients with the VCP mutation2019
- Author(s)
  中村亮一
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] Genetic and functional analysis of the KIF5A variants in Japanese patients with sporadic amyotrophic lateral sclerosis.2019
- Author(s)
  Ryoichi Nakamura, Naoki Atsuta, Genki Tohnai, Masahiro Nakatochi, Naoki Hayashi, Masahisa Katsuno, Yuishin Izumi, Akira Taniguchi, Nobutaka Hattori, Mitsuya Morita, Osamu Kano, Satoshi Kuwabara, Masaya Oda, Koji Abe, Kouichi Mizoguchi, Ryuji Kaji, Gen Sobue, JaCALS
- Organizer
  30th international symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07973
[Presentation] Frequency and characteristics of the TBK1 gene variants in Japanese patients with sporadic ALS2018
- Author(s)
  藤内玄規, 中村亮一, 曽根淳, 中杤昌弘, 横井大知, 勝野雅央, 和泉唯信, 森田光哉, 谷口彰, 桑原聡, 阿部康二, 溝口功一, 青木正志, 服部信孝, 辻省次, 梶龍兒, 熱田直樹, 祖父江元, JaCALS
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K16116
[Presentation] Validation of genetic factors affecting survival in Japanese ALS patients2018
- Author(s)
  Ryoichi Nakamura, Naoki Atsuta, Genki Tohnai, Masahiro Nakatochi, Naoki Hayashi, Daichi Yokoi, Hirohisa Watanabe, Masahisa Katsuno, et al.
- Organizer
  29th International Symposium on ALS/MND.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16116
[Presentation] 前頭側頭葉変性症の早期診断へ向けた尾状核体積自動測定システムの開発2018
- Author(s)
  加藤隼康, 山下典生, 渡辺宏久, 大嶽れい子, 田中康博, 小倉礼, 川畑和也, 桝田道人, 横井孝政, 原一洋, 中村亮一, 熱田直樹, 勝野雅央, 祖父江元
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K16116
[Presentation] VCP 遺伝子変異が認められた4 家系の臨床像2018
- Author(s)
  中村亮一、安藤孝志、原一洋、熱田直樹、勝野雅央
- Organizer
  多系統蛋白質症(MSP)の疾患概念確立および診断基準作成、診療体制構築に関する研究班会議
- Data Source
  KAKENHI-PROJECT-17K16116
[Presentation] 多施設共同前向きコホートでみたALS患者に対する気管切開下陽圧換気療法の予後2018
- Author(s)
  林直毅, 熱田直樹, 横井大知, 中村亮一, 伊藤瑞規, 渡辺宏久, 勝野雅央, 和泉唯信, 饗場郁子, 狩野修, 谷口彰, 森田光哉, 阿部康二, 金井数明, 服部信孝, 青木正志, 桑原聡, 梶龍兒, 祖父江元, JaCALS
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K16116
[Presentation] 筋萎縮性側索硬化症の脳萎縮様式の多様性と認知機能の関係性2018
- Author(s)
  加藤隼康, 渡辺宏久, 山下典生, 川畑和也, 蝦名潤哉, 大嶽れい子, 田中康博, 吉田有佑, 小倉礼, 桝田道人, 原一洋, 中村亮一, 熱田直樹, 勝野雅央, 祖父江元
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16116
[Presentation] Validation of genetic factors affecting survival in Japanese ALS patients2018
- Author(s)
  中村亮一, 熱田直樹, 藤内玄規, 中杤昌弘, 林直毅, 横井大知, 渡辺宏久, 勝野雅央, 和泉唯信, 森田光哉, 谷口彰, 服部信孝, 狩野修, 織田雅也, 阿部康二, 桑原聡, 溝口功一, 梶龍兒, 祖父江元, JaCALS
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K16116
[Presentation] Prognosis of Japanese patients with amyotrophic lateral sclerosis according to motor phenotype2018
- Author(s)
  Naoki Atsuta, Daichi Yokoi, Ryoichi Nakamura, Hazuki Watanabe, Naoki Hayashi, Mizuki Ito, Hirohisa Watanabe, Masahisa Katsuno, Yuishin Izumi, Mitsuya Morita, Akira Taniguchi, Masaya Oda, Koji Abe, Kouichi Mizoguchi, Osamu Kano, Satoshi Kuwabara, Masashi Aoki, Nobutaka Hattori, Ryuji Kaji, & Gen Sobue, JaCALS
- Organizer
  PACTALS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09778
[Presentation] ALSFRS-Rを用いた筋萎縮性側索硬化症患者の進行、予後予測と治験デザイン2018
- Author(s)
  熱田直樹、中村亮一、林直毅、横井大知、伊藤瑞規、渡辺宏久、勝野雅央、和泉唯信、森田光哉、谷口彰、織田雅也、阿部康二、狩野修、桑原聡、青木正志、金井数明、服部信孝、梶龍兒、祖父江元、JaCALS
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09778
[Presentation] ALSFRS-Rを用いた筋萎縮性側索硬化症患者の進行、予後予測と治験デザイン2018
- Author(s)
  熱田直樹, 中村亮一, 林直毅, 横井大知, 伊藤瑞規, 渡辺宏久, 勝野雅央, 和泉唯信, 森田光哉, 谷口彰, 織田雅也, 阿部康二, 狩野修, 桑原聡, 青木正志, 金井数明, 服部信孝, 梶龍兒, 祖父江元, JaCALS
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K16116
[Presentation] Prognosis of Japanese patients with amyotrophic lateral sclerosis according to motor phenotype2017
- Author(s)
  Naoki Atsuta, Daichi Yokoi, Ryoichi Nakamura, Hazuki Watanabe, Naoki Hayashi, Mizuki Ito, Hirohisa Watanabe, Masahisa Katsuno, Yuishin Izumi, Mitsuya Morita, Akira Taniguchi, Masaya Oda, Koji Abe, Kouichi Mizoguchi, Osamu Kano, Satoshi Kuwabara, Masashi Aoki, Nobutaka Hattori, Ryuji Kaji, & Gen Sobue, JaCALS
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09778
[Presentation] 頸部と右上肢の振戦が中心症状だった神経核内封入体病の一例2017
- Author(s)
  兒玉憲人, 武井藍, 牧美充, 中村友紀, 橋口昭大, 野妻智嗣, 田代雄一, 曽根淳, 祖父江元, 高嶋博
- Organizer
  第217 回日本神経学会九州地方会
- Data Source
  KAKENHI-PROJECT-15K09312
[Presentation] Clinical characteristics of familial and sporadic amyotrophic lateral sclerosis patients with G93S mutation in the SOD1 gene.2017
- Author(s)
  Ryoichi Nakamura, Naoki Atsuta, Genki Tohnai, Daichi Yokoi, Hazuki Watanabe, Naoki Hayashi, Jun Sone, Mizuki Ito, Hirohisa Watanabe, Masahisa Katsuno, Yuishin Izumi, Rina Hashimoto, Ikuko Aiba, Kouichi Mizoguchi, Ryuji Kaji, & Gen Sobue, JaCALS.
- Organizer
  World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16116
[Presentation] The SMN gene copy number states in Japanese ALS patients2016
- Author(s)
  石原智彦、豊田佐織、小山哲秀、熱田直樹、中村亮一、藤内玄規、曽根淳、和泉唯信、梶龍兒、森田光哉、谷口彰、祖父江元、JaCALS、小野寺理、西澤正豊
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K19485
[Presentation] A rapid functional decline type of sporadic ALS is linked to low expression of TTN2016
- Author(s)
  渡辺　はづき、平川　晃弘、中村亮一、中杤昌弘、石垣　診祐、飯田　有俊、池川　志郎、横井大知、勝野雅央、和泉唯信、森田光哉、谷口彰、阿部康二、溝口功一、狩野修、梶龍兒、祖父江元、JaCALS
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K19485
[Presentation] 次世代シークエンサーを用いたALS関連遺伝子多型の探索2016
- Author(s)
  中村亮一、祖父江元、曽根淳、中杤昌弘、藤内玄規、勝野雅央、熱田直樹.
- Organizer
  平成27年度次世代シークエンサーを用いた孤発性の神経難病の発症機構の解明と治療法開発に関する研究班会議
- Place of Presentation
  神戸大学医学部附属病院（兵庫県神戸市）
- Year and Date
  2016-03-04
- Data Source
  KAKENHI-PROJECT-15K19485
[Presentation] ALS患者に対する換気補助療法の予後2016
- Author(s)
  横井大知、熱田直樹、渡辺　はづき、中村亮一、平川　晃弘、伊藤瑞規、渡辺宏久、勝野雅央、和泉唯信、森田光哉、谷口彰、織田雅也、阿部康二、溝口功一、狩野修、桑原聡、梶龍兒、祖父江元
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K19485
[Presentation] 孤発性筋萎縮性側索硬化症患者における発症年齢と遺伝学的背景に関する検討2016
- Author(s)
  中村亮一、曽根淳、熱田直樹、藤内玄規、横井大知、中杤昌弘、渡辺宏久、伊藤瑞規、勝野雅央、和泉唯信、森田光哉、谷口彰、服部信孝、織田雅也、狩野修、桑原聡、阿部康二、梶龍兒、祖父江元、JaCALS
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター（兵庫県神戸市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K19485
[Presentation] Comprehensive genetic screening of 28 ALS-related genes in a Japanese ALS cohort2015
- Author(s)
  Ryoichi Nakamura, Jun Sone, Naoki Atsuta, Genki Tohnai, Hazuki Watanabe, Daichi Yokoi, Masahiro Nakatochi, Hirohisa Watanabe, Mizuki Ito, Masahisa Katsuno, Fumiaki Tanaka, Nobutaka Hattori, Yuishin Izumi, Mitsuya Morita, Akira Taniguchi, Koji Abe, Masaya Oda, Koichi Mizoguchi, Ryuji Kaji, Gen Sobue.
- Organizer
  26th international symposium on ALS/MND
- Place of Presentation
  Orland (USA)
- Year and Date
  2015-12-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19485
[Presentation] 日本におけるALS疾患関連遺伝子の網羅的解析2015
- Author(s)
  中村亮一、曽根淳、熱田直樹、藤内玄規、中杤昌弘、渡辺はづき、横井大知、渡辺宏久、伊藤瑞規、勝野雅央、田中章景、服部信孝、和泉唯信、森田光哉、谷口彰、阿部康二、織田雅也、溝口功一、梶龍兒、祖父江元
- Organizer
  第33回日本神経治療学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋）
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-15K19485

1. Atsuta Naoki (90547457)

# of Collaborated Projects: 6 results

# of Collaborated Products: 62 results
2. TOHNAI Genki (00748353)

# of Collaborated Projects: 6 results

# of Collaborated Products: 35 results
3. 祖父江元 (20148315)

# of Collaborated Projects: 5 results

# of Collaborated Products: 20 results
4. KATSUNO Masahisa (50402566)

# of Collaborated Projects: 3 results

# of Collaborated Products: 41 results
5. 道勇学 (90293703)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. Sone Jun (40513750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 陸雄一 (50748382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 岡田洋平 (30383714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. SUZUKI Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. NAKAMURA Yasuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. WATANABE Hirohisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. ITO kengo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. TANABE hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. UEDA Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 加藤昇平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. BAGARMAO Epifanio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 伊藤卓治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 青木正志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 割田仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 大平英樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 小野寺一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 石垣診祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakamura Ryoichi 中村 亮一

NAKAMURA Ryoichi 中村 亮一

Research Projects

Research Products

Co-Researchers

ALSにおける老化によるタンパク質品質管理機構の発現変化と病態への影響

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Elucidating the heterogeneity of amyotrophic lateral sclerosis by neuropathological analysis linked to clinical genomic information

Principal Investigator

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筋萎縮性側索硬化症のmissing heritabilityに関わる遺伝子の探索Principal Investigator

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候補遺伝子アプローチによる筋萎縮性側索硬化症病態関連遺伝子の探索Principal Investigator

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Research Institution

Therapeutic development based on factors affecting progression and prognosis of amyotrophic lateral sclerosis

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Analysis of genes affecting cognitive function in sporadic ALSPrincipal Investigator

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Investigation of clinical picture and causative gene of NIID

Principal Investigator

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Comprehensive genetic analysis of ALS-related genes in Japanese sporadic ALS patientsPrincipal Investigator

Principal Investigator

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[Journal Article] ALSFRS-R decline rate prior to baseline is not useful for stratifying subsequent progression of functional decline2024

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[Journal Article] Nationwide survey of patients with multisystem proteinopathy in Japan2024

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[Journal Article] 多因子性神経難病の全ゲノム解析：筋萎縮性側索硬化症2023

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[Journal Article] Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients2023

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[Journal Article] 多因子性神経難病の全ゲノム解析：筋萎縮性側索硬化症2023

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[Journal Article] The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK2022

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Nakamura Ryoichi 中村亮一

NAKAMURA Ryoichi 中村亮一

[Journal Article] 【神経疾患とゲノム医療】個別病態・疾患のゲノム医療　筋萎縮性側索硬化症2022

[Journal Article] 【神経疾患とゲノム医療】個別病態・疾患のゲノム医療　筋萎縮性側索硬化症2022