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Usui Tatsuya  臼井 達哉

ORCIDConnect your ORCID iD *help
Researcher Number 80727652
Other IDs
Affiliation (Current) 2022: 東京農工大学, (連合)農学研究科(研究院), 特任講師
Affiliation (based on the past Project Information) *help 2017 – 2022: 東京農工大学, (連合)農学研究科(研究院), 特任講師
2015: 山口大学, 共同獣医学部, 助教
2014: 山口大学, 獣医学部, 助教
Review Section/Research Field
Principal Investigator
Veterinary medical science / Basic Section 42020:Veterinary medical science-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields
Except Principal Investigator
Basic Section 42020:Veterinary medical science-related / Veterinary medical science
Keywords
Principal Investigator
オルガノイド / 肺がん / 炎症 / DAPK3 / オートファジー / がん / 腸 / DAPK / 血管内皮細胞 / 血管内皮 … More / 共培養 / 三次元培養 / 血管 / 膀胱がん / 尿中細菌 / 犬 / 抗がん剤 / 猫 / オーガンオンチップ … More
Except Principal Investigator
犬 / オルガノイド / 前立腺がん / 抗がん剤 / イヌ / 尿サンプル / キャビテーション / 癌治療 / 抗癌剤 / 超音波 / 取り込み / 音響キャビテーション / 中皮腫 / メソテリン / 腫瘍マーカー / 治療ターゲット分子 / 脂肪肝 / オートファジー / 肝前がん病変 / ラット / LC3 / NAFLD / 肝がん / 前がん病変 / 選択的オートファジー / 小胞体ファジー / ペキソファジー / PEX5 / p62 / FAM134B / 非アルコール性脂肪性肝疾患 Less
  • Research Projects

    (8 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (11 People)
  •  Establishment of cat multiorgan organoid-on-a-chip systemPrincipal Investigator

    • Principal Investigator
      臼井 達哉
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 42:Veterinary medical science, animal science, and related fields
    • Research Institution
      Tokyo University of Agriculture and Technology
  •  Exploratory research on novel diagnostic and therapeutic markers for mesothelioma

    • Principal Investigator
      打出 毅
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      Tokyo University of Agriculture and Technology
  •  Multidisciplinary research using urine-derived organoids: To overcome canine bladder cancerPrincipal Investigator

    • Principal Investigator
      臼井 達哉
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      Tokyo University of Agriculture and Technology
  •  Evaluation of selective autophagy in non-alcoholic steatosis-related hepatocarcinogenesis rat model

    • Principal Investigator
      吉田 敏則
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      Tokyo University of Agriculture and Technology
  •  Exploring novel therapeutic target genes for dog prostate cancer using urine-derived 3D cultureHost Researcher

    • Host Researcher
      臼井 達哉
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      Tokyo University of Agriculture and Technology
  •  Mechanisms of interactions between cancer and vascular endothelial cell using 3D mouse lung cancer modelPrincipal Investigator

    • Principal Investigator
      Usui Tatsuya
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Veterinary medical science
    • Research Institution
      Tokyo University of Agriculture and Technology
  •  Spatially selective anticancer drug uptake by ultrasonically induced cavitation

    • Principal Investigator
      SASAKI KAZUAKI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Veterinary medical science
    • Research Institution
      Tokyo University of Agriculture and Technology
  •  Mechanisms of novel inflammatory molecule, DAPK3 on inflammatory bowl diseasePrincipal Investigator

    • Principal Investigator
      Usui Tatsuya
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Veterinary medical science
    • Research Institution
      Yamaguchi University

All 2022 2021 2020 2019 2018 2016 2015 2014 Other

All Journal Article Presentation Book Patent

  • [Book] 肺がんオルガノイド・血管内皮細胞共培養システムを用いた細胞間相互作用メカニズムの解明2018

    • Author(s)
      臼井達哉、佐々木一昭
    • Total Pages
      5
    • Publisher
      北隆館
    • ISBN
    • Data Source
      KAKENHI-PROJECT-17K15370
  • [Book] ガンの分子メカニズムと治療戦略2018

    • Author(s)
      臼井達哉、佐々木一昭
    • Total Pages
      54
    • Publisher
      ニューサイエンス社
    • Data Source
      KAKENHI-PROJECT-17K15370
  • [Journal Article] Featured Article:The Potential of Organoids in Toxicologic Pathology-Role of toxicologic pathologists in in vitro chemical hepatotoxicity assessment2022

    • Author(s)
      Toshinori Yoshida, Mio Kobayashi, Suzuka Uomoto, Kanami Ohshima, Emika Hara, Yoshitaka Katoh, Naofumi Takahashi, Takanori Harada, Tatsuya Usui, Mohamed Elbadawy, Makoto Shibutani.
    • Journal Title

      Journal of Toxicologic Pathology, in press

      Volume: 3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03146
  • [Journal Article] 尿サンプル由来イヌ移行上皮癌オルガノイド培養法を用いた 抗がん剤感受性検査の開発2022

    • Author(s)
      佐藤よもぎ、Mohamed Elbadawy、山本晴、森正弘、森崇、中川貴之、前田真吾、野口俊助、岩井聡美、呰上大吾、打出毅、福島隆治、篠原佑太、臼井達哉、佐々木一昭
    • Journal Title

      日本獣医腎泌尿器学雑誌

      Volume: 14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03145
  • [Journal Article] Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism2021

    • Author(s)
      Mohamed Elbadawy, Yomogi Sato, Takashi Mori, Yuta Goto, Kimika Hayashi, 1Megumi Yamanaka, 5 Daigo Azakami, Tsuyoshi Uchide, Ryuji Fukushima, Toshinori Yoshida, Makoto Shibutani, Mio Kobayashi, Yuta Shinohara, Amira Abugomaa, Masahiro Kaneda, Hideyuki Yamawaki, Tatsuya Usui, Kazuaki Sasaki
    • Journal Title

      Cancer Biology & therapy

      Volume: 22 Pages: 357-371

    • DOI

      10.1080/15384047.2021.1919004

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03145
  • [Journal Article] Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer2020

    • Author(s)
      Abugomaa A, Elbadawy M, Yamawaki H, Usui T
    • Journal Title

      Cells

      Volume: 9

    • DOI

      10.3390/cells9010235

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18F18397
  • [Journal Article] Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture2020

    • Author(s)
      Abugomaa Amira、Elbadawy Mohamed、Yamanaka Megumi、Goto Yuta、Hayashi Kimika、Mori Takashi、Uchide Tsuyoshi、Azakami Daigo、Fukushima Ryuji、Yoshida Toshinori、Shibutani Makoto、Yamashita Risako、Kobayashi Mio、Yamawaki Hideyuki、Shinohara Yuta、Kaneda Masahiro、Usui Tatsuya、Sasaki Kazuaki
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 9393-9393

    • DOI

      10.1038/s41598-020-66229-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06368, KAKENHI-PROJECT-20H03145, KAKENHI-PROJECT-18F18397
  • [Journal Article] Development of prostate cancer organoid culture models in basic medicine and translational research2020

    • Author(s)
      2.Elbadawy M, Abugomaa A, Yamawaki H, Usui T, Sasaki K
    • Journal Title

      Cancers

      Volume: 12 Pages: 777-777

    • DOI

      10.3390/cancers12040777

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18F18397
  • [Journal Article] Establishment of a novel experimental model for muscle-invasive bladder cancer using a dog bladder cancer organoid culture2019

    • Author(s)
      Mohamed Elbadawy, Tatsuya Usui, Masahiro Kaneda, et al.
    • Journal Title

      Cancer Science

      Volume: 110 Pages: 2806-2821

    • DOI

      10.1111/cas.14118

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06368, KAKENHI-PROJECT-19K09218, KAKENHI-PROJECT-18F18397
  • [Journal Article] Regulation of Beclin 1 Phosphorylation and Autophagy by PP2A and DAPK3.2016

    • Author(s)
      Fujiwara N, Usui T, Ohama T, Sato K
    • Journal Title

      J Biol Chem

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26850182
  • [Journal Article] Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation.2015

    • Author(s)
      Yabe R, Miura A, Usui T, Mudrak I, Ogris E, Ohama T*, Sato K
    • Journal Title

      PLoS One

      Volume: 10(12)

    • DOI

      10.1371/journal.pone.0145226

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14856, KAKENHI-PROJECT-15J07273, KAKENHI-PROJECT-26850182
  • [Journal Article] Eukaryotic elongation factor 2 kinase controls proliferation and migration of vascular smooth muscle cells.2015

    • Author(s)
      Usui T, Nijima R, Sakatsume T, Otani K, Kameshima S, Okada M, Yamawaki H.
    • Journal Title

      Acta Physiol (Oxf)

      Volume: 213 Pages: 472-480

    • DOI

      10.1111/apha.12354

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26850182
  • [Journal Article] The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma2015

    • Author(s)
      Enjoji S, Yabe R, Fujiwara N, Tsuji S, Vitek MP, Mizuno T, Nakagawa T, Usui T, Ohama T, Sato K
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 77 Issue: 11 Pages: 1451-1456

    • DOI

      10.1292/jvms.15-0193

    • NAID

      130005112083

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15J07273, KAKENHI-PROJECT-26850182
  • [Journal Article] Characterization of SET/I2PP2A isoforms in dogs2014

    • Author(s)
      Yabe R, Fujiwara N, Mizuno T, Usui T, Ohama T, Sato K
    • Journal Title

      J Vet Med Sci.

      Volume: 76 Pages: 1235-1240

    • NAID

      130004432203

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26850182
  • [Journal Article] Death-associated protein kinase 3 mediates vascular structural remodelling via stimulating smooth muscle cell proliferation and migration.2014

    • Author(s)
      Usui T, Sakatsume T, Nijima R, Otani K, Kazama K, Morita T, Kameshima S, Okada M, Yamawaki H.
    • Journal Title

      Clin Sci (Lond).

      Volume: 127 Pages: 539-548

    • DOI

      10.1042/cs20130591

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26850182
  • [Journal Article] Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells.2014

    • Author(s)
      Usui T, Naruo A, Okada M, Hayabe Y, and Yamawaki H.
    • Journal Title

      Acta Physiol (Oxf).

      Volume: In Press Pages: 385-394

    • DOI

      10.1111/apha.12249

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25660233, KAKENHI-PROJECT-26850182
  • [Patent] 特許権2020

    • Inventor(s)
      臼井達哉 佐々木一昭 他
    • Industrial Property Rights Holder
      臼井達哉 佐々木一昭 他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-051580
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-20H03145
  • [Patent] 特許権2020

    • Inventor(s)
      臼井達哉、佐々木一昭、モハメド エルバダウィー他
    • Industrial Property Rights Holder
      臼井達哉、佐々木一昭、モハメド エルバダウィー他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-051580
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-18F18397
  • [Presentation] イヌ正常膀胱オルガノイド培養モデルの確立2022

    • Author(s)
      山本晴、藤坂航大、モハメドエルバダウィー、石原勇介、呰上大吾、打出毅、福島隆二、森崇、臼井達哉、佐々木一昭
    • Organizer
      第17回日本獣医内科学アカデミー学術集会
    • Data Source
      KAKENHI-PROJECT-20H03145
  • [Presentation] 三次元オルガノイド培養法を用いたオーダーメイド獣医療の開発と創薬への応用2021

    • Author(s)
      臼井達哉
    • Organizer
      医薬品毒性機序研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03145
  • [Presentation] 尿サンプル由来イヌ移行上皮癌オルガノイド培養法を用いた 抗がん剤感受性検査の開発2021

    • Author(s)
      佐藤よもぎ, モハメドエルバダウィー、山本晴、森正弘、森崇、中川貴之、前田真吾、野口俊助、岩井聡美、呰上大吾、打出毅、福島隆治、臼井達哉、佐々木一昭
    • Organizer
      第17回日本獣医内科学アカデミー学術集会
    • Data Source
      KAKENHI-PROJECT-20H03145
  • [Presentation] 3次元オルガノイド培養法を用いたイヌ正常膀胱のin vitroでの再現および解析2021

    • Author(s)
      藤坂航大,モハメドエルバダウィー, 山本晴, 石原勇介,,臼井達哉 佐々木一昭
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03145
  • [Presentation] 犬膀胱がん2.5Dオルガノイド培養法の確立2020

    • Author(s)
      アミラ アブゴマー、臼井 達哉、佐々木 一昭
    • Organizer
      第163回日本獣医学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H03145
  • [Presentation] オルガノイド培養法を用いた犬膀胱がんに対するTrametinibの薬効薬理評価2020

    • Author(s)
      ○後藤 悠太,臼井 達哉,エルバダヴィー モハメド ,林 希佳,山中 恵
    • Organizer
      第143回日本薬理学会関東部会
    • Data Source
      KAKENHI-PROJECT-20H03145
  • [Presentation] Establishment of a culture method of dog bladder cancer organoids2019

    • Author(s)
      Tatsuya Usui
    • Organizer
      Cell Symposia Engineering Organoids and Organs
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18F18397
  • [Presentation] 三次元マウス肺がんと血管内皮細胞の共培養システムの樹立2018

    • Author(s)
      臼井 達哉
    • Organizer
      日本毒性学会
    • Data Source
      KAKENHI-PROJECT-17K15370
  • [Presentation] パルス超音波による抗がん剤の 抗腫瘍効果促進について2018

    • Author(s)
      山本晴、臼井達哉、東隆、佐々木一昭
    • Organizer
      第161回日本獣医学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08046
  • [Presentation] Mechanisms of death-associated protein kinase3 to regulate the development of lung cancer2015

    • Author(s)
      臼井 達哉
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26850182
  • [Presentation] Death-associated protein kinase 3 promotes proliferation and migration of A549 human lung cancer cells via activating the ERK/c-Myc signaling

    • Author(s)
      臼井 達哉
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-03-18 – 2015-03-20
    • Data Source
      KAKENHI-PROJECT-26850182
  • 1.  打出 毅 (20327456)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 2.  大松 勉 (60455392)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  SASAKI KAZUAKI (10421934)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  下田 実 (50154323)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  恒富 亮一 (10420514)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  吉田 敏則 (80726456)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  川野 竜司 (90401702)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KEWAN MOHAMED
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  OHAMA Takashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  KANEDA Masahiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 11.  山脇 英之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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