Usui Tatsuya 臼井達哉

Researcher Number	80727652
Other IDs
Affiliation (Current)	2023: 東京農工大学, (連合)農学研究科(研究院), 准教授
Affiliation (based on the past Project Information) *help	2017 – 2022: 東京農工大学, (連合)農学研究科(研究院), 特任講師 2015: 山口大学, 共同獣医学部, 助教 2014: 山口大学, 獣医学部, 助教
Review Section/Research Field	Principal Investigator Veterinary medical science / Basic Section 42020:Veterinary medical science-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields Except Principal Investigator Basic Section 42020:Veterinary medical science-related / Veterinary medical science
Keywords	Principal Investigator オルガノイド / 肺がん / 炎症 / DAPK3 / オートファジー / がん / 腸 / DAPK / 血管内皮細胞 / 血管内皮 … More / 共培養 / 三次元培養 / 血管 / 膀胱がん / 尿中細菌 / 犬 / 抗がん剤 / 猫 / オーガンオンチップ … More Except Principal Investigator 犬 / オルガノイド / 前立腺がん / 抗がん剤 / イヌ / 尿サンプル / キャビテーション / 癌治療 / 抗癌剤 / 超音波 / 取り込み / 音響キャビテーション / 中皮腫 / メソテリン / 腫瘍マーカー / 治療ターゲット分子 / 脂肪肝 / オートファジー / 肝前がん病変 / ラット / LC3 / NAFLD / 肝がん / 前がん病変 / 選択的オートファジー / 小胞体ファジー / ペキソファジー / PEX5 / p62 / FAM134B / 非アルコール性脂肪性肝疾患 Less

Establishment of cat multiorgan organoid-on-a-chip systemPrincipal Investigator
- Principal Investigator
  
  臼井達哉
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Tokyo University of Agriculture and Technology
Exploratory research on novel diagnostic and therapeutic markers for mesothelioma
- Principal Investigator
  
  打出毅
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Tokyo University of Agriculture and Technology
Multidisciplinary research using urine-derived organoids: To overcome canine bladder cancerPrincipal Investigator
- Principal Investigator
  
  臼井達哉
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Tokyo University of Agriculture and Technology
Evaluation of selective autophagy in non-alcoholic steatosis-related hepatocarcinogenesis rat model
- Principal Investigator
  
  吉田敏則
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Tokyo University of Agriculture and Technology
Exploring novel therapeutic target genes for dog prostate cancer using urine-derived 3D cultureHost Researcher
- Host Researcher
  
  臼井達哉
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Tokyo University of Agriculture and Technology
Mechanisms of interactions between cancer and vascular endothelial cell using 3D mouse lung cancer modelPrincipal Investigator
- Principal Investigator
  
  Usui Tatsuya
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Tokyo University of Agriculture and Technology
Spatially selective anticancer drug uptake by ultrasonically induced cavitation
- Principal Investigator
  
  SASAKI KAZUAKI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  Tokyo University of Agriculture and Technology
Mechanisms of novel inflammatory molecule, DAPK3 on inflammatory bowl diseasePrincipal Investigator
- Principal Investigator
  
  Usui Tatsuya
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Yamaguchi University

All 2022 2021 2020 2019 2018 2016 2015 2014 Other

All Journal Article Presentation Book Patent

[Book] 肺がんオルガノイド・血管内皮細胞共培養システムを用いた細胞間相互作用メカニズムの解明2018
- Author(s)
  臼井達哉、佐々木一昭
- Total Pages
  5
- Publisher
  北隆館
- ISBN
- Data Source
  KAKENHI-PROJECT-17K15370
[Book] ガンの分子メカニズムと治療戦略2018
- Author(s)
  臼井達哉、佐々木一昭
- Total Pages
  54
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-17K15370
[Journal Article] Featured Article：The Potential of Organoids in Toxicologic Pathology-Role of toxicologic pathologists in in vitro chemical hepatotoxicity assessment2022
- Author(s)
  Toshinori Yoshida, Mio Kobayashi, Suzuka Uomoto, Kanami Ohshima, Emika Hara, Yoshitaka Katoh, Naofumi Takahashi, Takanori Harada, Tatsuya Usui, Mohamed Elbadawy, Makoto Shibutani.
- Journal Title
  
  Journal of Toxicologic Pathology, in press
  
  Volume: 3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03146
[Journal Article] 尿サンプル由来イヌ移行上皮癌オルガノイド培養法を用いた抗がん剤感受性検査の開発2022
- Author(s)
  佐藤よもぎ、Mohamed Elbadawy、山本晴、森正弘、森崇、中川貴之、前田真吾、野口俊助、岩井聡美、呰上大吾、打出毅、福島隆治、篠原佑太、臼井達哉、佐々木一昭
- Journal Title
  
  日本獣医腎泌尿器学雑誌
  
  Volume: 14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03145
[Journal Article] Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism2021
- Author(s)
  Mohamed Elbadawy, Yomogi Sato, Takashi Mori, Yuta Goto, Kimika Hayashi, 1Megumi Yamanaka, 5 Daigo Azakami, Tsuyoshi Uchide, Ryuji Fukushima, Toshinori Yoshida, Makoto Shibutani, Mio Kobayashi, Yuta Shinohara, Amira Abugomaa, Masahiro Kaneda, Hideyuki Yamawaki, Tatsuya Usui, Kazuaki Sasaki
- Journal Title
  
  Cancer Biology & therapy
  
  Volume: 22 Pages: 357-371
- DOI
  10.1080/15384047.2021.1919004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03145
[Journal Article] Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer2020
- Author(s)
  Abugomaa A, Elbadawy M, Yamawaki H, Usui T
- Journal Title
  
  Cells
  
  Volume: 9
- DOI
  10.3390/cells9010235
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18F18397
[Journal Article] Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture2020
- Author(s)
  Abugomaa Amira、Elbadawy Mohamed、Yamanaka Megumi、Goto Yuta、Hayashi Kimika、Mori Takashi、Uchide Tsuyoshi、Azakami Daigo、Fukushima Ryuji、Yoshida Toshinori、Shibutani Makoto、Yamashita Risako、Kobayashi Mio、Yamawaki Hideyuki、Shinohara Yuta、Kaneda Masahiro、Usui Tatsuya、Sasaki Kazuaki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 9393-9393
- DOI
  10.1038/s41598-020-66229-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06368, KAKENHI-PROJECT-20H03145, KAKENHI-PROJECT-18F18397
[Journal Article] Development of prostate cancer organoid culture models in basic medicine and translational research2020
- Author(s)
  2.Elbadawy M, Abugomaa A, Yamawaki H, Usui T, Sasaki K
- Journal Title
  
  Cancers
  
  Volume: 12 Pages: 777-777
- DOI
  10.3390/cancers12040777
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18F18397
[Journal Article] Establishment of a novel experimental model for muscle-invasive bladder cancer using a dog bladder cancer organoid culture2019
- Author(s)
  Mohamed Elbadawy, Tatsuya Usui, Masahiro Kaneda, et al.
- Journal Title
  
  Cancer Science
  
  Volume: 110 Pages: 2806-2821
- DOI
  10.1111/cas.14118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06368, KAKENHI-PROJECT-19K09218, KAKENHI-PROJECT-18F18397
[Journal Article] Regulation of Beclin 1 Phosphorylation and Autophagy by PP2A and DAPK3.2016
- Author(s)
  Fujiwara N, Usui T, Ohama T, Sato K
- Journal Title
  
  J Biol Chem
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26850182
[Journal Article] Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation.2015
- Author(s)
  Yabe R, Miura A, Usui T, Mudrak I, Ogris E, Ohama T*, Sato K
- Journal Title
  
  PLoS One
  
  Volume: 10(12)
- DOI
  10.1371/journal.pone.0145226
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14856, KAKENHI-PROJECT-15J07273, KAKENHI-PROJECT-26850182
[Journal Article] Eukaryotic elongation factor 2 kinase controls proliferation and migration of vascular smooth muscle cells.2015
- Author(s)
  Usui T, Nijima R, Sakatsume T, Otani K, Kameshima S, Okada M, Yamawaki H.
- Journal Title
  
  Acta Physiol (Oxf)
  
  Volume: 213 Pages: 472-480
- DOI
  10.1111/apha.12354
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26850182
[Journal Article] The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma2015
- Author(s)
  Enjoji S, Yabe R, Fujiwara N, Tsuji S, Vitek MP, Mizuno T, Nakagawa T, Usui T, Ohama T, Sato K
- Journal Title
  
  J. Vet. Med. Sci.
  
  Volume: 77 Issue: 11 Pages: 1451-1456
- DOI
  10.1292/jvms.15-0193
- NAID
  130005112083
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15J07273, KAKENHI-PROJECT-26850182
[Journal Article] Characterization of SET/I2PP2A isoforms in dogs2014
- Author(s)
  Yabe R, Fujiwara N, Mizuno T, Usui T, Ohama T, Sato K
- Journal Title
  
  J Vet Med Sci.
  
  Volume: 76 Pages: 1235-1240
- NAID
  130004432203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26850182
[Journal Article] Death-associated protein kinase 3 mediates vascular structural remodelling via stimulating smooth muscle cell proliferation and migration.2014
- Author(s)
  Usui T, Sakatsume T, Nijima R, Otani K, Kazama K, Morita T, Kameshima S, Okada M, Yamawaki H.
- Journal Title
  
  Clin Sci (Lond).
  
  Volume: 127 Pages: 539-548
- DOI
  10.1042/cs20130591
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26850182
[Journal Article] Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells.2014
- Author(s)
  Usui T, Naruo A, Okada M, Hayabe Y, and Yamawaki H.
- Journal Title
  
  Acta Physiol (Oxf).
  
  Volume: In Press Pages: 385-394
- DOI
  10.1111/apha.12249
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25660233, KAKENHI-PROJECT-26850182
[Patent] 特許権2020
- Inventor(s)
  臼井達哉佐々木一昭　他
- Industrial Property Rights Holder
  臼井達哉佐々木一昭　他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-051580
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20H03145
[Patent] 特許権2020
- Inventor(s)
  臼井達哉、佐々木一昭、モハメド　エルバダウィー他
- Industrial Property Rights Holder
  臼井達哉、佐々木一昭、モハメド　エルバダウィー他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-051580
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18F18397
[Presentation] イヌ正常膀胱オルガノイド培養モデルの確立2022
- Author(s)
  山本晴、藤坂航大、モハメドエルバダウィー、石原勇介、呰上大吾、打出毅、福島隆二、森崇、臼井達哉、佐々木一昭
- Organizer
  第17回日本獣医内科学アカデミー学術集会
- Data Source
  KAKENHI-PROJECT-20H03145
[Presentation] 三次元オルガノイド培養法を用いたオーダーメイド獣医療の開発と創薬への応用2021
- Author(s)
  臼井達哉
- Organizer
  医薬品毒性機序研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03145
[Presentation] 尿サンプル由来イヌ移行上皮癌オルガノイド培養法を用いた抗がん剤感受性検査の開発2021
- Author(s)
  佐藤よもぎ, モハメドエルバダウィー、山本晴、森正弘、森崇、中川貴之、前田真吾、野口俊助、岩井聡美、呰上大吾、打出毅、福島隆治、臼井達哉、佐々木一昭
- Organizer
  第17回日本獣医内科学アカデミー学術集会
- Data Source
  KAKENHI-PROJECT-20H03145
[Presentation] 3次元オルガノイド培養法を用いたイヌ正常膀胱のin vitroでの再現および解析2021
- Author(s)
  藤坂航大,モハメドエルバダウィー, 山本晴, 石原勇介,,臼井達哉佐々木一昭
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03145
[Presentation] 犬膀胱がん2.5Dオルガノイド培養法の確立2020
- Author(s)
  アミラアブゴマー、臼井達哉、佐々木一昭
- Organizer
  第163回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03145
[Presentation] オルガノイド培養法を用いた犬膀胱がんに対するTrametinibの薬効薬理評価2020
- Author(s)
  ○後藤悠太，臼井達哉，エルバダヴィーモハメド，林希佳，山中恵
- Organizer
  第143回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20H03145
[Presentation] Establishment of a culture method of dog bladder cancer organoids2019
- Author(s)
  Tatsuya Usui
- Organizer
  Cell Symposia Engineering Organoids and Organs
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18F18397
[Presentation] 三次元マウス肺がんと血管内皮細胞の共培養システムの樹立2018
- Author(s)
  臼井達哉
- Organizer
  日本毒性学会
- Data Source
  KAKENHI-PROJECT-17K15370
[Presentation] パルス超音波による抗がん剤の抗腫瘍効果促進について2018
- Author(s)
  山本晴、臼井達哉、東隆、佐々木一昭
- Organizer
  第161回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08046
[Presentation] Mechanisms of death-associated protein kinase3 to regulate the development of lung cancer2015
- Author(s)
  臼井　達哉
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26850182
[Presentation] Death-associated protein kinase 3 promotes proliferation and migration of A549 human lung cancer cells via activating the ERK/c-Myc signaling
- Author(s)
  臼井　達哉
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26850182

1. 打出毅 (20327456)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 大松勉 (60455392)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SASAKI KAZUAKI (10421934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 下田実 (50154323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 恒富亮一 (10420514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 吉田敏則 (80726456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 川野竜司 (90401702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KEWAN MOHAMED

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OHAMA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. KANEDA Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 山脇英之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Usui Tatsuya 臼井 達哉

Research Projects

Research Products

Co-Researchers

Establishment of cat multiorgan organoid-on-a-chip systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploratory research on novel diagnostic and therapeutic markers for mesothelioma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Multidisciplinary research using urine-derived organoids: To overcome canine bladder cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of selective autophagy in non-alcoholic steatosis-related hepatocarcinogenesis rat model

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring novel therapeutic target genes for dog prostate cancer using urine-derived 3D cultureHost Researcher

Host Researcher

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of interactions between cancer and vascular endothelial cell using 3D mouse lung cancer modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Spatially selective anticancer drug uptake by ultrasonically induced cavitation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of novel inflammatory molecule, DAPK3 on inflammatory bowl diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 肺がんオルガノイド・血管内皮細胞共培養システムを用いた細胞間相互作用メカニズムの解明2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] ガンの分子メカニズムと治療戦略2018

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Featured Article：The Potential of Organoids in Toxicologic Pathology-Role of toxicologic pathologists in in vitro chemical hepatotoxicity assessment2022

Author(s)

Journal Title

Data Source

[Journal Article] 尿サンプル由来イヌ移行上皮癌オルガノイド培養法を用いた 抗がん剤感受性検査の開発2022

Author(s)

Journal Title

Data Source

[Journal Article] Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer2020

Author(s)

Journal Title

DOI

Usui Tatsuya 臼井達哉

[Journal Article] 尿サンプル由来イヌ移行上皮癌オルガノイド培養法を用いた抗がん剤感受性検査の開発2022