Aikawa Shizu 藍川志津

Researcher Number	80884577
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 特任研究員
Affiliation (based on the past Project Information) *help	2020 – 2024: 東京大学, 医学部附属病院, 特任研究員 2022: 東京大学, 医学部附属病院, 特別研究員
Review Section/Research Field	Principal Investigator Basic Section 44020:Developmental biology-related / 0802:Biomedical structure and function and related fields / Basic Section 56040:Obstetrics and gynecology-related Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 42040:Laboratory animal science-related
Keywords	Principal Investigator 胚着床 / リピドーム / トランスクリプトーム / 子宮内膜 / 着床 / 胚発生 / Hif2a / 胚浸潤 / Lif / 妊娠 … More Except Principal Investigator … More 着床不全 / マウスモデル / 子宮内膜 / 不妊症 / 胚浸潤 / 着床障害 / 着床能 / 脱落膜 / 子宮内膜間質 / エピゲノム / ヒストン修飾 / 胚移植反復不成功 / エピゲノム調節 / 活性化胚盤胞 / ヒストンメチル化 / 子宮 / 卵管 / 細胞死 / シクロオキシゲナーゼ / プロスタグランジン / 体外受精・胚移植 / 妊娠 / 着床 / 子宮頸部細胞 / バイオマーカー / LIF / 子宮頸部 Less

Elucidation of the mechanisms of embryo-endometrial interactions induced by cell death
- Principal Investigator
  
  廣田泰
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  The University of Tokyo
Molecular mechanisms of embryo implantation triggered by mechanical stress
- Principal Investigator
  
  大須賀穣
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
胚発生活性化を担保する着床期胚・子宮内膜間相互作用の解明Principal Investigator
- Principal Investigator
  
  藍川志津
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  The University of Tokyo
Development of a new diagnostic method for implantation failure using cervical cells
- Principal Investigator
  
  廣田泰
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
Mechanism of blastocyst invasion controlled by uterine factors
- Principal Investigator
  
  廣田泰
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
Identification of functional lipids of the uterus and application to fertility treatment
- Principal Investigator
  
  Osuga Yutaka
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  The University of Tokyo
Development of diagnostic method for implantation failure focusing on histone modification of the endometrium
- Principal Investigator
  
  Osuga Yutaka
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
Analysis of Lif-induced blastocyst activation and implantationPrincipal Investigator
- Principal Investigator
  
  Aikawa Shizu
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  The University of Tokyo
低酸素シグナルを介した受精卵着床機構の解析Principal Investigator
- Principal Investigator
  
  藍川志津
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0802:Biomedical structure and function and related fields
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] 脂質メディエーターによる妊娠初期過程制御2023
- Author(s)
  藍川志津, 廣田泰
- Journal Title
  
  実験医学
  
  Volume: 72 Pages: 2909-2913
- Data Source
  KAKENHI-PROJECT-22K19596
[Journal Article] The EZH2?PRC2?H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion2023
- Author(s)
  Fukui Yamato、Hirota Yasushi、Aikawa Shizu、Sakashita Akihiko、Shimizu-Hirota Ryoko、Takeda Norihiko、Ishizawa Chihiro、Iida Rei、Kaku Tetsuaki、Hirata Tomoyuki、Hiraoka Takehiro、Akaeda Shun、Matsuo Mitsunori、Osuga Yutaka
- Journal Title
  
  Cell Death & Disease
  
  Volume: 14 Issue: 5 Pages: 320-320
- DOI
  10.1038/s41419-023-05832-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15814, KAKENHI-PROJECT-23K15827, KAKENHI-PROJECT-22K19596, KAKENHI-PUBLICLY-22H04700, KAKENHI-PROJECT-23K23803
[Journal Article] 特集　子宮内膜機能の基礎と臨床子宮内膜機能と胚着床-胚浸潤の観点から-2022
- Author(s)
  藍川志津、廣田泰
- Journal Title
  
  HORMONE FRONTIER IN GYNECOLOGY
  
  Volume: 29 Issue: 3 Pages: 37-41
- DOI
  10.34449/J0015.29.03_0037-0041
- ISSN
  1340-220X
- Year and Date
  2022-09-01
- Data Source
  KAKENHI-PROJECT-22K19595, KAKENHI-PROJECT-22K19596, KAKENHI-PROJECT-23K23803
[Journal Article] Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females2022
- Author(s)
  Hiraoka Takehiro、Hirota Yasushi、Aikawa Shizu、Iida Rei、Ishizawa Chihiro、Kaku Tetsuaki、Hirata Tomoyuki、Fukui Yamato、Akaeda Shun、Matsuo Mitsunori、Shimizu-Hirota Ryoko、Takeda Norihiko、Osuga Yutaka
- Journal Title
  
  Endocrinology
  
  Volume: 163 Issue: 5
- DOI
  10.1210/endocr/bqac044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-22K19595, KAKENHI-PROJECT-22K16852, KAKENHI-PROJECT-19H03144, KAKENHI-PROJECT-22K19596, KAKENHI-PROJECT-19H03796
[Journal Article] DNA Methylation and Histone Modification Are the Possible Regulators of Preimplantation Blastocyst Activation in Mice2022
- Author(s)
  Hiratsuka Daiki、Aikawa Shizu、Hirota Yasushi、Fukui Yamato、Akaeda Shun、Hiraoka Takehiro、Matsuo Mitsunori、Osuga Yutaka
- Journal Title
  
  Reproductive Sciences
  
  Volume: 30 Issue: 2 Pages: 494-525
- DOI
  10.1007/s43032-022-00988-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19595, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K23803
[Journal Article] A gene network of uterine luminal epithelium organizes mouse blastocyst implantation2022
- Author(s)
  Aikawa Shizu、Hirota Yasushi、Fukui Yamato、Ishizawa Chihiro、IIda Rei、Kaku Tetsuaki、Hirata Tomoyuki、Akaeda Shun、Hiraoka Takehiro、Matsuo Mitsunori、Osuga Yutaka
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 21 Issue: 1
- DOI
  10.1002/rmb2.12435
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-21J00509, KAKENHI-PROJECT-22K19595, KAKENHI-PROJECT-22K16852, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-19H03144, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-23K23803
[Journal Article] Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion2021
- Author(s)
  Akaeda Shun、Hirota Yasushi、Fukui Yamato、Aikawa Shizu、Shimizu‐Hirota Ryoko、Kaku Tetsuaki、Gebril Mona、Hirata Tomoyuki、Hiraoka Takehiro、Matsuo Mitsunori、Haraguchi Hirofumi、Saito‐Kanatani Mayuko、Takeda Norihiko、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  EMBO reports
  
  Volume: 22 Issue: 2
- DOI
  10.15252/embr.202050927
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-19K18630, KAKENHI-PROJECT-19K18631, KAKENHI-PROJECT-20K22732, KAKENHI-PROJECT-19H03144
[Journal Article] Uterine Receptivity is Reflected by LIF Expression in the Cervix2021
- Author(s)
  Fukui Yamato、Hirota Yasushi、Aikawa Shizu、Ishizawa Chihiro、Iida Rei、Kaku Tetsuaki、Hirata Tomoyuki、Akaeda Shun、Hiraoka Takehiro、Matsuo Mitsunori、Osuga Yutaka
- Journal Title
  
  Reproductive Sciences
  
  Volume: 29 Issue: 5 Pages: 1457-1462
- DOI
  10.1007/s43032-021-00816-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-21J00509, KAKENHI-PROJECT-22K19595, KAKENHI-PROJECT-22K16852, KAKENHI-PROJECT-19H03144, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-23K23803
[Journal Article] Uterine Epithelial Progesterone Receptor Governs Uterine Receptivity Through Epithelial Cell Differentiation2020
- Author(s)
  Gebril Mona、Hirota Yasushi、Aikawa Shizu、Fukui Yamato、Kaku Tetsuaki、Matsuo Mitsunori、Hirata Tomoyuki、Akaeda Shun、Hiraoka Takehiro、Shimizu-Hirota Ryoko、Takeda Norihiko、Taha Tamer、Balah Osama Al、Elnoury Mohamed Amr H、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Endocrinology
  
  Volume: 161 Issue: 12 Pages: 12-12
- DOI
  10.1210/endocr/bqaa195
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-20K22732, KAKENHI-PROJECT-19H03144
[Journal Article] Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment2020
- Author(s)
  Hiraoka Takehiro、Hirota Yasushi、Fukui Yamato、Gebril Mona、Kaku Tetsuaki、Aikawa Shizu、Hirata Tomoyuki、Akaeda Shun、Matsuo Mitsunori、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Shimizu-Hirota Ryoko、Takeda Norihiko、Yoshino Osamu、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 15523-15523
- DOI
  10.1038/s41598-020-72640-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09823, KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-19K18630, KAKENHI-PROJECT-19K18631, KAKENHI-PROJECT-20K22732, KAKENHI-PROJECT-19H03144
[Presentation] 子宮におけるEZH2-PRC2-H3K27me3経路が胚浸潤において果たす役割2023
- Author(s)
  福井大和, 廣田泰, 藍川志津, 石沢千尋, He Xueting, 飯田麗, 赤枝俊, 平岡毅大, 松尾光徳, 大須賀穣
- Organizer
  第41回日本受精着床学会
- Data Source
  KAKENHI-PROJECT-22K19596
[Presentation] 反復着床不全子宮腺筋症合併不妊に対する治療指針の探求2022
- Author(s)
  松尾光徳, 廣田泰, 藍川志津, 石沢千尋, 飯田麗, 平田知之, 賀来哲明, 福井大和, 赤枝俊, 平岡毅大, 大須賀穣
- Organizer
  第67回日本生殖医学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19595
[Presentation] 着床期子宮におけるプロスタグランジンシグナルを介した胚生育巣形成機構.2022
- Author(s)
  藍川志津, 廣田泰, 有田誠, 磯部洋輔, 杉浦悠毅, 赤枝俊, 松尾光徳, 大須賀穣
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K23803
[Presentation] 着床期子宮におけるプロスタグランジンシグナルを介した胚生育巣形成機構2022
- Author(s)
  藍川志津, 廣田泰, 有田誠, 磯部洋輔, 杉浦悠毅, 赤枝俊, 松尾光徳, 大須賀穣
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K19595
[Presentation] 反復着床不全子宮腺筋症合併不妊に対する治療指針の探求2022
- Author(s)
  松尾光徳, 廣田泰, 藍川志津, 石沢千尋, 飯田麗, 平田知之, 賀来哲明, 福井大和, 赤枝俊, 平岡毅大, 大須賀穣
- Organizer
  第67回日本生殖医学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-23K23803

1. 廣田泰 (40598653)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
2. Osuga Yutaka (80260496)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. 赤枝俊 (10898084)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. 清水良子 (30348643)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 松尾光徳 (00823618)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 平岡毅大 (20836762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. 甲賀かをり (10396723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 平池修 (20529060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 原田美由紀 (70451812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 可野邦行 (50636404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 坂下陽彦 (60893873)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 平田哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 吉野修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Aikawa Shizu 藍川 志津

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanisms of embryo-endometrial interactions induced by cell death

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of embryo implantation triggered by mechanical stress

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

胚発生活性化を担保する着床期胚・子宮内膜間相互作用の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new diagnostic method for implantation failure using cervical cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of blastocyst invasion controlled by uterine factors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of functional lipids of the uterus and application to fertility treatment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of diagnostic method for implantation failure focusing on histone modification of the endometrium

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of Lif-induced blastocyst activation and implantationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

低酸素シグナルを介した受精卵着床機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] 脂質メディエーターによる妊娠初期過程制御2023

Author(s)

Journal Title

Data Source

[Journal Article] The EZH2?PRC2?H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 特集 子宮内膜機能の基礎と臨床 子宮内膜機能と胚着床-胚浸潤の観点から-2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA Methylation and Histone Modification Are the Possible Regulators of Preimplantation Blastocyst Activation in Mice2022

Aikawa Shizu 藍川志津

[Journal Article] 特集　子宮内膜機能の基礎と臨床子宮内膜機能と胚着床-胚浸潤の観点から-2022

[Presentation] 反復着床不全子宮腺筋症合併不妊に対する治療指針の探求2022

[Presentation] 反復着床不全子宮腺筋症合併不妊に対する治療指針の探求2022