KAWATA Sumio 河田純男

… Alternative Names

河田純男カワタスミオ

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Researcher Number	90183285
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Affiliation (based on the past Project Information) *help	2008: 山形大学, 副学長 2000 – 2007: 山形大学, 医学部, 教授 1999 – 2000: Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 1994 – 1998: 大阪大学, 医学部, 助教授 1996 – 1997: 大阪大学, 医学部, 教授 … More 1993: Osaka University, Internal Medicine, Assistant Professor, 医学部, 講師 1991 – 1992: 大阪大学, 医学部, 助手 1988 – 1989: 大阪大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology / 内分泌・代謝学 / Biological Sciences Except Principal Investigator Gastroenterology / Gastroenterology / Pathological medical chemistry / 内分泌・代謝学 / Metabolomics
Keywords	Principal Investigator 肝細胞癌 / TGF-β / oval cell / 肝幹細胞 / TGF-βレセプター / 幹細胞 / 大腸がん / 細胞増殖 / 肝細胞 / 増殖抑制因子 … More / FGF2 / SCF / TPO / bone marrow cells / 骨髄細胞 / Matrigel / Notch signal / 肝再生 / Musashi-1 gene / oval cells / TGF-b receptor / TGF-b / TGF-β レセプター / cell growth / 遺伝子変異 / manumycin / Ras p21 / 高TGF-β血症 / 酵素阻害剤 / TGF-β受容体 / HB-EGF / 肥満症 / VLDL / 脂肪肝 / liver regeneration therapy / hepatic stem cells / bone marrow cell transplantation / hepatic failure / musashi-1 / 劇症肝炎 / 造血幹細胞増殖因子 / 肝不全 / 再生医療 / 自家骨髄移植 / 重症肝不全 / GFP transgenic mice / Hepatic stem cells / Liver regeneration / natchシグナル / Musashi-1遺伝子 / oval cell line / GFPトランスジェニック・マウス / Musashi-1 / GFPトランスジェニックマウス / Musashi-1遺伝 / angiotensin II / Angiotensin II receptor / chronic hepatitis C / hepatic cirrhosis / Hepatic fibrosis / アンギオテンシン受容体 / アンギオテンシン / アンギオテンシンII受容体 / アンギオテンシンII / 受容体阻害薬 / アンギオテンジンII受容体 / アンギオテンジンII / C型慢性肝炎 / 肝硬変 / 肝線維化 / Hepatoma cell lines / hepatocytes / Hepatic Stem cell / 肝癌細胞株 / Musashi遺伝子 / anti-TGF-b therapy / plasma TGF-b1 / 抗TGF-β療法 / gene mutation / Hepatocellular carcinoma / TGF-beta receptor / hepatocellular cacinoma / Farnesyl ; protein transferase / Vascular smooth muscle cells / Atherosclerosis / 増殖抑制 / 血管平滑筋細胞 / HPLC / ファネルシルトランスフェラーゼ / Rasp21 / ファルネシルトランスフェラーゼ / 動脈平滑筋細胞 / 動脈硬化 / 脂肪酸合成 / 脂肪蓄積機序 / acetyl-CoA carboxylase / apolipoprotein B mRNA / Triglyceride / 大腸がん予防 / インスリン抵抗性 / adiponectin / 内臓脂肪 / 大腸腺腫 / NASH / 再発予測因子 / TGF-β1 / 予後予測因子 / musashi遺伝子 / 肝細胞移植 / ファルネシル転移酵素 / 化学予防 / ファルネシルトランスフェラーゼ阻害剤 / フェルネシルトランスフェラーゼ / ras癌遺伝子産物 / 受容体 / EGF / HGF / 増殖抑制機構 / 癌化 / 増殖因子 / bioassay / ELISA / DNA合成 / 肝硬変症 / TGFーβ mRNA / TGFーβレセプタ- / TGFーβ / acetylーCoA carboxylase / コリン欠乏食 / sucrose / apoB / mRNA … More Except Principal Investigator HB-EGF / in vivo / 増殖因子 / 肝再生 / SNP / 肝細胞 / HCV replicon / TLR2 / Hepatitis C / 遺伝子多型 / 肝細胞癌 / signal transduction / Grap / Flt-1 / growth factor / hepatocyte / liver regeneration / 治療 / 血管新生 / NK4 / c-Met / HGF / 遺伝子治療 / Rabphilin-3A / Rab3A / CD44 / The ERM family / Rho / B-Raf / Ras / HCV / C型肝炎 / 遺伝子発現 / 類洞内皮細胞 / Single nucleotide polymorphism / Innate immune / 自然免疫 / C型慢性肝炎 / glycosylation / cohort / cell membrane / susceptibility of infection / genetic polymorphism / host / 感染防御 / ヘパラン硫酸 / 接合蛋白 / 感染感受性 / 糖鎖 / コホート / 細胞膜 / SNP感染感受性 / 遺伝子多型性 / 宿主 / Immunotherapy / Dendritic cell / Cancer vaccine / Pervention / Hepatocellular carcinoma / 癌ワクチン療法 / 免疫療法 / 樹状細胞 / 癌ワクチン / 再発予防 / 幹細胞癌 / gene therapy / HVJ-liposome / soluble-HB-EGF / HVJ-リポソーム / 可溶型HB-EGF / hepatocellular carcinom / endothelial cel / angiogenesis / SH2蛋白 / 血管内皮細胞 / visceral fat / in vitro model of artery wall / transform / smooth muscle cell / atherosclerosis / ノックアウトマウス / 内臓脂肪 / 血管壁再構築3次元モデル / 形質変換 / 血管平滑筋細胞 / 動脈硬化 / therapy / マウス / 肝産生 / MB-EGF / metastasis / invasion / tumor-stromal interaction / tumor / HGF antagonist / レセプター / サイトカイン / 癌浸潤・転移 / 腫瘍 / 癌細胞 / c-met / コラーゲンゲル内浸潤 / 基底膜浸潤 / 浸潤・転移抑制剤 / 浸潤・転移 / 癌治療 / 転移 / 浸潤 / 癌-間質相互作用 / 腫瘍・癌 / HGFアンタゴニスト / Gene therapy / HVJ-liposome method / Familial hypercholesterolemia / HVJ-liposome法 / 家族性高コレステロール血症 / small GTP-binding protein / ERM-CD44系 / 14-3-3蛋白質 / SMAP / SmgGDS / Rap1 / 低分子量G蛋白質 / 低分子量GTP結合蛋白質 / carnitine transport activity / heart failure / fatty liver / mit DNA / long chain fatty acid / mitochondria / cardiomegaly / carnitine / 尿素サイクル / 高脂血症 / 高アンモニア血症 / トリアシルグリセロール / 総脂質 / カルニチン輸送活性 / 心不全 / 脂肪肝 / 心肥大 / ミトコンドリアDNA / ミトコンドリア / 長鎖脂肪酸 / カルニチン / nonspecific lipid transfer protein / cytosol protein / 肝ミクロソーム / コルステロール7αー水酸化酵素 / 胆汁酸生合成 / コレステロール生合成 / 胆石症 / siRNA / 感染症 / 脂質ラフト / 脂質 / TM7SF2 / 遺伝子導入 / 発癌 / 大腸癌 / 肝癌 / ヒト癌 / ファルネシルトランスフェラーゼ / 抗カドヘリン抗体 / 細胞間接着 / クッパー細胞 / ヘパリン結合性EGF様増殖因子 Less

Analysis of TM7SF2 Gene in Hepatitis C Virus Infection
- Principal Investigator
  
  SAITO Takafumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamagata University
Functional dissection of a polymorphism in TLR2 gene associated with liver fibrosis in chronic hepatitis C
- Principal Investigator
  
  LI Shao
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamagata University
Development of liver regeneration therapy for severe hepatic failure.Principal Investigator
- Principal Investigator
  
  KAWATA Sumio
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamagata University
Analysis of Human Adaptor Protein Gene in Hepatitis C Virus Infection
- Principal Investigator
  
  SAITO Takafumi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamagata University
内臓脂肪蓄積による生体防御機能破綻を基盤とした消化器病態と分子機構の解明Principal Investigator
- Principal Investigator
  
  河田純男
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yamagata University
Development of liver regeneration therapy against severe hepatic failure based on stem cell science -Differentiation and growth of hepatic stem cell and cell transplantation.Principal Investigator
- Principal Investigator
  
  KAWATA Sumio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamagata University
大腸がんに新たに見出された高TGF-β血症の意義解明と戦略的治療法への応用―予後予測を基盤とした再発阻止のための抗TGF-β療法の開発―Principal Investigator
- Principal Investigator
  
  河田純男
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Yamagata University
Antitumor immunotherapeutic effect of immunization with fusion of dendritic cells and hepatocellular carcinoma cells in mice
- Principal Investigator
  
  SATO Koji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamagata University
Development of strategic therapy for severe hepatic failure using regenerative medicine-Isolation of hepatic stem cell expressing musashi-1 gene and cell therapyPrincipal Investigator
- Principal Investigator
  
  KAWATA Sumio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamagata University
Development of hepatic anti-fibrotic therapy targeted to angiotensin II receptor antagonist-soppression of collagen production in the Ito cell via TGF-βPrincipal Investigator
- Principal Investigator
  
  KAWATA Sumio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Yamagata University
肝幹細胞(liver stem cells)を用いた肝細胞移植療法の開発Principal Investigator
- Principal Investigator
  
  河田純男
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Yamagata University
The mechanism for tumor angiogenesis in hepatocellular carcinoma : focused on the signal transduction pathway by Flt-1
- Principal Investigator
  
  ITO Nobuyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Study on the gene therapy of soluble-HB-EGF gene to accelerate liver regeneration.
- Principal Investigator
  
  TAMURA Shinji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
ファルネシル転移酵素を標的とした大腸がんの化学予防に関する基礎的研究Principal Investigator
- Principal Investigator
  
  河田純男
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
Atherosclerosis and knockout mouse of HB-EGF
- Principal Investigator
  
  INUI Yoshiaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
発癌・癌進展におけるras−ファルネシルトランスフェラーゼ発現の意義とその解明
- Principal Investigator
  
  松田幸彦
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
ALTERED GROWTH CONTROL OF HEPATOCYTES DURING THE CARCINOGENESIS AND ITS REGULATIONPrincipal Investigator
- Principal Investigator
  
  KAWATA Sumio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Elevation of plasma TGF-b in cancer patients and study on its molecular mechanism.Principal Investigator
- Principal Investigator
  
  KAWATA Sumio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Effect of HB-EGF on liver regeneration in vovo and its application as a therapeutic agent.
- Principal Investigator
  
  TAMURA Shinji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
細胞間接着弛緩による肝再生開始機構の解明-ヘパリン結合性FGF様増殖因子遺伝子発現機構の検討
- Principal Investigator
  
  田村信司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Study on abnormality in growth regulation hepatic carcinogenesis and its control.Principal Investigator
- Principal Investigator
  
  KAWATA Sumio
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Ras癌遺伝子産物を標的とした細胞増殖制御に関する基礎的研究-ファルネシルトランスフェラーゼ発現とその抑制Principal Investigator
- Principal Investigator
  
  河田純男
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
肝細胞の癌化に伴う増殖調節機構の異常とその制御-TGF-βレセプター構造異常の解析と遺伝子治療への応用-Principal Investigator
- Principal Investigator
  
  河田純男
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
新しい肝再生因子の発見とその肝細胞増殖促進機構の解明-ヘパリン結合性EGF様増殖因子の再生肝における遺伝子発現機構
- Principal Investigator
  
  田村信司
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Inhibitory effects of HGF antagonist on invasion/metastasis of tumor cells.
- Principal Investigator
  
  NAKAMURA Toshikazu
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
ヒト肝発癌過程における増殖抑制因子受容体の遺伝子異常の解析Principal Investigator
- Principal Investigator
  
  河田純男
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
cDNAs and antibodies for small GTP-binding proteins
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
Development of new drug therapy for atherosclerosisPrincipal Investigator
- Principal Investigator
  
  KAWATA Sumio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
Development of Therapy for Refractory Hyperlipidemia with LDL Receptor Gene Introduction by Lipofection Method
- Principal Investigator
  
  MATSUZAWA Yuji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
ヒト肝発癌過程における増殖因子・増殖抑制因子およびそれらの受容体遺伝子発現異常Principal Investigator
- Principal Investigator
  
  河田純男
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
肝硬変症からの発癌過程における増殖抑制機構の異常とその制御に関する研究Principal Investigator
- Principal Investigator
  
  河田純男
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Role of Carnitine on Lipid and Carbohydrate Metagolism
- Principal Investigator
  
  KUWAJIMA Masamichi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
肝細胞の癌化に伴なう増殖抑制機構の異常に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  河田純男
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
脂肪肝における脂肪蓄積機序に関する分子生物学的研究Principal Investigator
- Principal Investigator
  
  河田純男
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
肥満における脂肪肝の成因ーapolipoprotein B mRNA定量による検討Principal Investigator
- Principal Investigator
  
  河田純男
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
胆石症におけるコレステロールおよび胆汁酸生合成の調節機構に関する研究
- Principal Investigator
  
  田島幸児
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University

All 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Book

[Book] Annual Review 消化器2007
- Author(s)
  河田純男
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] What can be revealed by extending the sensitivity of HBsAg detection to below the present limit?2008
- Author(s)
  Togashi H, Hashimoto C, Yokozawa J, Suzuki A, Sugahara K, Saito T, Yamaguchi I, Badawi H, Kainuma N, Aoyama M, Ohya H, Akatsuka T, Tanaka Y, Mizokami M, Kawata S
- Journal Title
  
  Journal of Hepatology 49
  
  Pages: 17-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590746
[Journal Article] Common null variant, Arg192Stop, in a G-protein coupled receptor, olfactory receptor 1B1, associated with decreased serum cholinesterase activity2008
- Author(s)
  Koyano S, Emi M, Toriyama S, Ishii M, Saito T, Makino N, Kubota I, Kato T, Kawata S
- Journal Title
  
  Hepatology Research 38
  
  Pages: 696-703
- NAID
  10021945389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590746
[Journal Article] Common null variant, Arg192Stop, in a G-protein coupled receptor, of factory receptor 1B1, associated with decreased serum cholinesterase activity2008
- Author(s)
  Koyano S, Emi M, Saito T, Kawata S, et.al.
- Journal Title
  
  Hepatology Research 38
  
  Pages: 696-703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590746
[Journal Article] Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population2008
- Author(s)
  Daimon M, Sato H, Oizumi T, Toriyama S, Saito T, Karasawa S, Jimbu Y, Wada K, Kameda W, Susa S, Yamaguchi H, Emi M, Muramatsu M, Kubota I, Kawata S, Kato T
- Journal Title
  
  Biochem. Biophys. Res. Commun 365
  
  Pages: 466-471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590746
[Journal Article] Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population2008
- Author(s)
  Daimon M, Sato T, Saito T, Kawata S, et.al.
- Journal Title
  
  Biochem Biophys Res Commun 365
  
  Pages: 466-471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590746
[Journal Article] What can be revealed by extending the sensitivity of HBsAg detection to below the present limit2008
- Author(s)
  Togashi H, Hashimoto C, Saito T, Kawata S, et.al.
- Journal Title
  
  Journal of Hepatology 49
  
  Pages: 17-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590746
[Journal Article] Risk of hepatocellular carcinoma and secondary structure of hepatitis C virus (HCV) NS3 protein amino-terminus among patients with HCV subtype 1b2007
- Author(s)
  Nishise Y, Saito T, Sugahara K, Ito J, Saito K, Togashi H, Nagano-Fujii M, Hotta H, Kawata S
- Journal Title
  
  Journal of Infectious Diseases 196
  
  Pages: 1006-1009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590746
[Journal Article] Functional polymorphisms in the Toll-Like receptor 2 gene and liver fibrosis in chronic hepatitis C2007
- Author(s)
  Shao L, Ishii K, Saito T, Watanabe H, Sugahara K, Nishise Y, Okumoto K, Ishii R, Kawata S, Ishikawa H, Fukao A
- Journal Title
  
  Hepatol Inter 1
  
  Pages: 139-139
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590715
[Journal Article] Impaired portal circulation resulting from L-arginine deficiency in patients with lysinuric protein intolerance.2006
- Author(s)
  Takeda T, Kawata S, et al.
- Journal Title
  
  Gut 55
  
  Pages: 1526-1527
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Impaired portal circulation resulting from L-arginine deficiency in patients with lysinuric protein intolerance.2006
- Author(s)
  Takeda T, Kawata S, et al.
- Journal Title
  
  Gut Vol 55
  
  Pages: 1526-1527
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Association of transforming growth factor-beta l functionalpolymorphisms with natural cleorance of hepatitis C virus.2006
- Author(s)
  Kimura T, Kawata S, et al.
- Journal Title
  
  J Infect Dis Vol 193
  
  Pages: 1371-1374
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Association of transforming growth factor-beta 1 functionalpolymorphisms with natural clearance of hepatitis C virus.2006
- Author(s)
  Kimura T, Kawata S, et al.
- Journal Title
  
  J Infect Dis Vol 193
  
  Pages: 1371-1374
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Characteristics of rat bone marrow cells differentiated into a liver cell lineage in the injured liver.2006
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  J Gastroenterol Vol 41
  
  Pages: 62-69
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Association of transforming growth factor-beta 1 functional polymorphisiiis with natural clearance of hepatitis C virus2006
- Author(s)
  Kimura T, Saito T, Yoshimura M, Yixuan S, Baba M, JiG, Muramatsu M, Kawata S.
- Journal Title
  
  J Infect Dis 193
  
  Pages: 1371-1374
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590715
[Journal Article] Characteristics of rat bone marrow cells differentiated into a liver lineage in the injured liver.2006
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  J Gastroenterol 41
  
  Pages: 62-69
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Association of transforming growth factor-beta 1 functional polymorphisms with natural clearance of hepatitis c virus.2006
- Author(s)
  Kimura T, Kawata S, et al.
- Journal Title
  
  J Infect Dis 193
  
  Pages: 1371-1374
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Differentiation of rat bone marrow cells cultured on artificial basement membrane containing extracellular marix into cell lineage.2005
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  J Hepatol Vol 43
  
  Pages: 110-116
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Association of visceral fat accumulation an plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance.2005
- Author(s)
  Otake S, Kawata S, et al.
- Journal Title
  
  Clin Cancer Res 11
  
  Pages: 3642-3646
- Data Source
  KAKENHI-PROJECT-16046202
[Journal Article] Expression of Notch signal markers in bone marrow cells that differentiate a Liver cell lineage in a rat transplant model.2005
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  Hepatol Res 31
  
  Pages: 7-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Expression of Notch signaling markers in bone marrow cells that differentiate into a liver cell lineage in a rat transplant model.2005
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  Hepatol Res 31
  
  Pages: 7-12
- NAID
  10015455865
- Data Source
  KAKENHI-PROJECT-16046202
[Journal Article] NADPH oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells.2005
- Author(s)
  Adachi T, Kawata S, et al.
- Journal Title
  
  Hepatology 41
  
  Pages: 120-126
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Enhanced expression of suppressor of cytokine signaling-1 in the liver of chronic hepatist C : possible involvement in resistance to interferon therapy.2005
- Author(s)
  Imanaka K, Kawata S, et al.
- Journal Title
  
  J Viral Hepat 12
  
  Pages: 130-138
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Hypermethylation of Chfr an hMLHl in gastric noninvasive and early invasive neoplasia.2005
- Author(s)
  Homma N, Kawata S, et al.
- Journal Title
  
  Virchow Arch 446
  
  Pages: 120-126
- Data Source
  KAKENHI-PROJECT-16046202
[Journal Article] Enhanced expression of SOCS-1 in the liver of chronic hepatitis C.2005
- Author(s)
  Imamura K, Kawata S, et al.
- Journal Title
  
  J Viral Hepat 12
  
  Pages: 130-138
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Enhanced expression of SOCS-1 in the liver of chronic hepatitis C.2005
- Author(s)
  Imanaka K, Kawata s, et al.
- Journal Title
  
  J Viral Hepat 12
  
  Pages: 130-138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Differenciation of rat bone marrow cells cultured on artificial basement membrane containing extracellular matri into cell lineage.2005
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  J Hepatol 43
  
  Pages: 110-116
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasia.2005
- Author(s)
  Homma N, Kawata S, et al.
- Journal Title
  
  Virchow Arch 446
  
  Pages: 120-126
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Expression of Notch signaling markers in bone marrow cells that differentiate into liver lineage in a rat transplant model.2005
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  Hepatol Res Vol 31
  
  Pages: 7-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Enhanced expression of suppressor of cytokine signaling-I in the liver of chronic hepatitis C : possible involevement in resistance to interferon therapy.2005
- Author(s)
  Imanaka K, Kawata S, et al.
- Journal Title
  
  J Viral Hepat 12
  
  Pages: 130-138
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Expression of Notch signaling markers in bone marrow cells that differentiate into a liver cell lineage in a rat transplant model.2005
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  Hepatol Res 31
  
  Pages: 7-12
- NAID
  10015455865
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Expression of Notch signaling markers in bone marrow cell that differentiate Into a liver cell lineage in a rat transplant model.2005
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  Hepatol Res 31
  
  Pages: 7-12
- NAID
  10015455865
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Differentiation of rat bone marrow cells cultured on artificial basement membrane containing extracellular matrix into liver cell lineage.2005
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  J Hepatol 43
  
  Pages: 110-116
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Association of visceral fat accumulation and plasma adiponectin with2005
- Author(s)
  Otake S, Kawata S, et al.
- Journal Title
  
  Cli Cancer Res (印刷中)
- Data Source
  KAKENHI-PROJECT-16046202
[Journal Article] Enhanced expression of suppressor of cytokine signaling-1 in the liver of chronic hepatitis C: possible involvement in resistance to interferon therapy.2005
- Author(s)
  Imanaka K, Kawata S, et al.
- Journal Title
  
  J Viral Hepat 12
  
  Pages: 130-138
- Data Source
  KAKENHI-PROJECT-16046202
[Journal Article] Expression of Notch signaling markers in bone marrow cells that differentiate into a liver cell lineage in a rat transplant model.2005
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  Hepatol Res 31
  
  Pages: 7-12
- NAID
  10015455865
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] NADPH oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells.2005
- Author(s)
  Adachi T, Kawata S, et al.
- Journal Title
  
  Hepatology Vol 41
  
  Pages: 120-126
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma : evidence for participation of insulin resistance.2005
- Author(s)
  Otake S, Kawata S, et al.
- Journal Title
  
  Clin Cancer Res 11
  
  Pages: 3642-3646
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] NADPH oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells.2005
- Author(s)
  Adachi T, Kawata S, et al.
- Journal Title
  
  Hepatology 41
  
  Pages: 1272-1281
- Data Source
  KAKENHI-PROJECT-16046202
[Journal Article] Differenciation of rat one marrow cells cultured on artificial basement membrane containing extracellular matri into cell lineage.2005
- Author(s)
  Okuumoto K, Kawata S, et al.
- Journal Title
  
  J Hepatol 43
  
  Pages: 110-116
- Data Source
  KAKENHI-PROJECT-16046202
[Journal Article] Expression of Notch signaling markers in bone marrow cells that differentiate into liver cell lineage in rat transplant model.2005
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  Hepatol Res 31
  
  Pages: 7-12
- NAID
  10015455865
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390214
[Journal Article] Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients.2004
- Author(s)
  Tozawa T, Kawata S, et al.
- Journal Title
  
  Cancer Sci 95
  
  Pages: 736-740
- NAID
  10014197338
- Data Source
  KAKENHI-PROJECT-16046202
[Journal Article] Possible contribution of circulating transforming growth factor- β1 to immunity and prognosis in unresectable hepatocellular carcinoma.2004
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  Liver International 24
  
  Pages: 21-28
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Transmission of hepatitis C virus quasispeces between human adults.2004
- Author(s)
  Saito T, Kawata S, et al.
- Journal Title
  
  Hepatol Res 30
  
  Pages: 57-62
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Genetic variation in humans associated with difference in the course of Hepatitis C.2004
- Author(s)
  Saito T, Kawata S, et al.
- Journal Title
  
  Biochem Biophys Res Commun 30
  
  Pages: 335-341
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Genetic variation in humans associated with differences in the course of hepatitis C.2004
- Author(s)
  Saito T, Kawata S, et al.
- Journal Title
  
  Biochem Biophys Res Commun 30
  
  Pages: 335-341
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma after a sustained response to interferon therapy.2004
- Author(s)
  Makiyama A, Kawata S, et al.
- Journal Title
  
  Cancer 101
  
  Pages: 1616-1622
- Data Source
  KAKENHI-PROJECT-16046202
[Journal Article] Demethylation of MAGE promoters during gastric cancer progression.2004
- Author(s)
  Honda T, Kawata S, et al.
- Journal Title
  
  Br J Cancer 90
  
  Pages: 838-843
- Data Source
  KAKENHI-PROJECT-16046202
[Journal Article] Promoter hypermethylation of the Chfr gene in neoplastic and non-neoplastic gastric epithelia.2004
- Author(s)
  Honda T, Kawata S, et al.
- Journal Title
  
  Br J Cancer 90
  
  Pages: 2013-2016
- Data Source
  KAKENHI-PROJECT-16046202
[Journal Article] Genetic variations in human associated with differences in the course of hepatitis C.2004
- Author(s)
  Saito T, Kawata S, et al.
- Journal Title
  
  Biochem Biophys Res Commun 30
  
  Pages: 335-341
- Data Source
  KAKENHI-PROJECT-16046202
[Journal Article] Interferon treatment improves survival in chronic hepatitis C patients showing biochemical as well as virological responses by preventing liver-related death.2004
- Author(s)
  Kasahara A, Kawata S, et al.
- Journal Title
  
  J Viral Hepat 11
  
  Pages: 148-156
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Liver regeneration in HB-EGF transgenic mice after partial hepatectomy.2003
- Author(s)
  Kiso S, Kawata S, et al.
- Journal Title
  
  Gastroenterology 124
  
  Pages: 701-707
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Differentiation of bone marrow cells into cells that express liver-specific genes Invitro.a a2003
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  Biochem Biophys Res Commun 304
  
  Pages: 691-695
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Separate of ASGR in the right and left hepatic lobe using 99Tc-GSA SPECT.2003
- Author(s)
  Sugahara K, Kawata S, et al.
- Journal Title
  
  Hepatology 38
  
  Pages: 1401-1409
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390224
[Journal Article] Differentiation of bone marrow cells into cells that express liver-specific genes In vitro.2003
- Author(s)
  Okumoto K, Kawata S, et al.
- Journal Title
  
  Biochem Biophys Res Commun 304
  
  Pages: 691-695
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390224
[Presentation] HCV NS3蛋白質二次構造の多型性とペグインターフェロン・リバビリン併用療法の効果予測2008
- Author(s)
  斎藤貴史、堀田博、河田純男
- Organizer
  第12回日本肝臓学会大会
- Place of Presentation
  東京都
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-19590746
[Presentation] Hyperprolactinemia associated with chronic hepatitis C and induction of prolactin expression in human peripheral blood mononuclear cells stimulated by hepatitis C virus2007
- Author(s)
  Ishii R, Saito T, Shao L, Ugajin S, Sato C, Haga H, Suzuki A, Misawa K, Sanjo M, Nishise Y, Okumoto K, Ito J, Sugahara K, Saito K, Togashi H, Kawata S
- Organizer
  58th AASLD
- Place of Presentation
  Boston, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590715
[Presentation] Functional polymorphisms in the Toll-Like receptor 2 gene and liver fibrosis in chronic hepatitis C2007
- Author(s)
  Shao L, Ishii K, Saito T, Watanabe H, Sugahara K, Nishise Y, Okumoto K, Ishii R, Kawata S, Ishikawa H, Fukao A
- Organizer
  17th APASL
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590715

1. TAMURA Shinji (30243223)

# of Collaborated Projects: 20 results

# of Collaborated Products: 0 results
2. SAITO Takafumi (80250918)

# of Collaborated Projects: 9 results

# of Collaborated Products: 16 results
3. INUI Yoshiaki (00294067)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
4. MATSUDA Yukihiko (90283770)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
5. ITO Nobuyuki (30273668)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
6. KISO Shinichi

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
7. FUKUDA Kazuto

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
8. SAITO Koji (90250919)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
9. MATSUZAWA Yuji (70116101)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
10. TOGASHI Hitoshi (60192209)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
11. WATANABE Hisayoshi (00332536)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
12. SHAO Li (80344787)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
13. YAMASHITA Shizuya (60243242)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. TAKEMURA Kaoru (00161240)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 藤岡滋典 (40218988)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 今井康陽 (20201337)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. 武田弘明 (90236480)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. NAKANO Hirofumi

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. KUWAJIMA Masamichi (00205262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TAKAI Yoshimi (60093514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SASAKI Takuya (40241278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TANAKA Kazuma (60188290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KANEDA Yasufumi (10177537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. NOZAKI Syuichi (30252646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. NAKAMURA Toshikazu (00049397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. MONDEN Morito (00127309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. FUNAKOSHI Hiroshi (40273685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. MATSUMOTO Kunio (90201780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. KOHNO Kenji (50142005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. SUGAHARA Kazuhiko (70333953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. ITO Junitsu (90344788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. FUKAO Akira (80156736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
33. 牧野直彦 (10323164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 田島幸児 (60188240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 片桐修一 (80167337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 川原康洋 (80169755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 中村正 (90252668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 根本康夫 (30250088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. KAYANOKI Yoshiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 中西孝至

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 山崎英二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 石川秀樹

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. KISO Shinich

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KAWATA Sumio 河田 純男

河田 純男 カワタ スミオ

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Development of liver regeneration therapy for severe hepatic failure.Principal Investigator

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内臓脂肪蓄積による生体防御機能破綻を基盤とした消化器病態と分子機構の解明Principal Investigator

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Development of liver regeneration therapy against severe hepatic failure based on stem cell science -Differentiation and growth of hepatic stem cell and cell transplantation.Principal Investigator

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大腸がんに新たに見出された高TGF-β血症の意義解明と戦略的治療法への応用―予後予測を基盤とした再発阻止のための抗TGF-β療法の開発―Principal Investigator

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Development of strategic therapy for severe hepatic failure using regenerative medicine-Isolation of hepatic stem cell expressing musashi-1 gene and cell therapyPrincipal Investigator

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Development of hepatic anti-fibrotic therapy targeted to angiotensin II receptor antagonist-soppression of collagen production in the Ito cell via TGF-βPrincipal Investigator

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肝幹細胞(liver stem cells)を用いた肝細胞移植療法の開発Principal Investigator

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ファルネシル転移酵素を標的とした大腸がんの化学予防に関する基礎的研究Principal Investigator

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KAWATA Sumio 河田純男

河田純男カワタスミオ