AKAGI Tsuyoshi 赤城剛

… Alternative Names

赤城剛アカギツヨシ

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Researcher Number	90184077
Other IDs
Affiliation (based on the past Project Information) *help	2006: Osaka Bioscience Institute, Vice Director, 第一研究室, 副部長 2005 – 2006: (財)大阪バイオサイエンス研究所, 分子腫瘍学部門, 研究員 2005: 財団法人大阪バイオサイエンス研究所, 分子腫瘍学研究部, 副部長 2004: 大阪バイオサイエンス研究所, 副部長 2004: 大阪バイオ研, 研究員 … More 2003 – 2004: (財)大阪バイオサイエンス研究所, 分子腫瘍学部門, 研究副部長 2002: Osaka Bioscience Institute, Director's Lab, Vice Head., 所長研究部, 研究副部長 2001 – 2002: 大阪バイオサイエンス研究所, 副部長 2001: (財)大阪バイオサイエンス研究所, 所長研究部, 副部長 1995 – 1996: 国立がんセンター研究所, ウイルス部, 室長 1995 – 1996: 国立がんセンター研究所, ウイルス部, 研究員 1994: 国立がんセンター, 研究員 1994: 国立がんセンター, ウイルス部, 研究員 1993: 国立がんセンター, ウイリス部, 研究員 1988: 国立がんセンター研究所, 研究員 Less
Review Section/Research Field	Principal Investigator Virology / Biological Sciences / Experimental pathology Except Principal Investigator Orthopaedic surgery / Orthopaedic surgery / Biological Sciences
Keywords	Principal Investigator 不死化 / HTLV-I / Ras / SH3 / SH2 / Src / FAK / AKT / PI3K / Cyclin … More / Tax1 / Tax遺伝子 / IL-2 / シグナル伝達 / Tリンパ球 / epidermal keratinocytes / transformation / immortalization / retroviral vector / normal human epithelial cells / ヒト正常上皮角化細胞 / ヒト正常表皮角化細胞 / テロメラーゼ / 癌化 / レトロウイルスベクター / ヒト正常上皮細胞 / Crk / P13K / v-CrK / v-Crk / EIA / SV40 T抗原 / ras / 老化 / 癌 / 細胞・組織 / 遺伝子 / 細胞不死化 / p53 / SdiI> / Cip1 / p21^<Waf1 / Cdk / Cell cvcle / T-cell / Cdk-Inhibitor / Cyclin-dependent Kinase(Cdk) / 細胞周期 / env遺伝子 / 抗原刺激 / HTLV-1 … More Except Principal Investigator SYT-SSX / p21 / Brm / synovial sarcoma / hBRM / 滑膜肉腫 / orthonedic surgery / sarcoma / choromatin remodeling / トランスジェニックマウス / p21WAF1 / senescence / 軟部腫瘍 / シグナル伝達 / 細胞老化 / クロマチン変換 / 整形外科 / 肉腫 / chromatin remodeling / transformation / Gene Therapy / Synovial sarcoma / Chromatin remodeling / 癌遺伝子 / クロマチリンリモデリング / 癌化 / 遺伝子治療 / クロマチンリモデリング / O^6-アルキルグアニン / アルキル化 / DNA附加体 / 発がん / DNA修復 / Src / Telomerase / Ras / RNAi / Anchorage / Integrin / FAK / p130Cas / Crk / SCIDマウス / トランスジェニックラット / Tax / ATL / トランスフォーメイション / 転写活性化因子 / HAM / HTLV-I / 転写活性化 / HTLV-1 / 成人T細胞白血病 Less

癌遺伝子による足場非依存性増殖能獲得のメカニズム
- Principal Investigator
  
  花房秀三郎
- Project Period (FY)
  2004 – 2008
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka Bioscience Institute
ヒト正常繊維芽細胞のトランスフォーメーションに対する抵抗性の分子機構Principal Investigator
- Principal Investigator
  
  赤城剛
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka Bioscience Institute
Analysis of human synovial sarcoma oncoprotein SYT-SSX and its therapeutic application.
- Principal Investigator
  
  TANAKA Shinya
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hokkaido University
Establishment of an efficient gene transfer system to normal epithelial cells and its application for cancer researchPrincipal Investigator
- Principal Investigator
  
  AKAGI Tsuyoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Osaka Bioscience Institute
ヒト正常細胞を用いた癌遺伝子の研究Principal Investigator
- Principal Investigator
  
  赤城剛
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka Bioscience Institute
Analysis of transforming mechanism of human synovial sarcoma oncogene SYT-SSX
- Principal Investigator
  
  TANAKA Shinya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  HOKKAIDO UNIVERSITY
A study on the mechanism of PI3K/AKT pathway activation by v-Crk oncogenePrincipal Investigator
- Principal Investigator
  
  AKAGI Tsuyoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Osaka Bioscience Institute
HTLV-I感染T細胞で高発現しているp21^<Waf1/Cip1/SdiI>の解析Principal Investigator
- Principal Investigator
  
  赤城剛
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
HTLV-1感染T細胞およびTax1導入T細胞における細胞周期関連遺伝子の発現Principal Investigator
- Principal Investigator
  
  赤城剛
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Virology
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
HTLV-1による細胞がん化の分子機構
- Principal Investigator
  
  菅村和夫
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
HTLV-1エンベロープタンパクのT細胞の増殖に対する影響Principal Investigator
- Principal Investigator
  
  赤城剛
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Virology
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
HTLV-1 Tax遺伝子を導入したヒト正常リンパ球の増殖能の解析Principal Investigator
- Principal Investigator
  
  赤城剛
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Virology
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
哺乳類O^6-アルキルグアニン修復酵素遺伝子のクローニング
- Principal Investigator
  
  許南浩
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo

All 2007 2006 2005 2004 2003

All Journal Article

[Journal Article] Normal human diploid fibroblasts are refractory to Ras-induced caveolin-1 down-regulation : implications in the resistance to oncogene-mediated transformation2007
- Author(s)
  Sasai K, Kakumoto K, Hanafusa H, Akagi T
- Journal Title
  
  Oncogene. 26・3
  
  Pages: 449-455
- Data Source
  KAKENHI-PROJECT-16002014
[Journal Article] Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals.2006
- Author(s)
  Segawa Y, Suga H, Iwabe N, Oneyama C, Akagi T, Miyata T, Okada M
- Journal Title
  
  Proc Natl Acad Sci USA. 103・32
  
  Pages: 12021-12026
- Data Source
  KAKENHI-PROJECT-16002014
[Journal Article] FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts2006
- Author(s)
  Kakumoto K, Sasai K, Sukezane T, Oneyama C, Ishimaru S, Shibutani K, Mizushima H, Mekada E, Hanafusa H, Akagi T
- Journal Title
  
  Proc Natl Acad Sci USA. 103・14
  
  Pages: 5490-5495
- Data Source
  KAKENHI-PROJECT-16002014
[Journal Article] Induction of p21WAF1/CIP1 by human synovial sarcoma-associated chimeric oncoprotein SYT-SSX12005
- Author(s)
  Tsuda M, Watanabe T, Seki T, Kimura T, Sawa H, Minami A, Akagi T, Isobe K, Nagashima K, Tanaka S
- Journal Title
  
  Oncogene 24(54)
  
  Pages: 7984-7990
- Data Source
  KAKENHI-PROJECT-16002014
[Journal Article] Human diploid fibroblasts are resistant to MEK/ERK-mediated disruption of the actin cytoskeleton and invasiveness stimulated by Ras.2005
- Author(s)
  Suezane T, Oneyama C, Kakumoto K, Shibutani K, Hanafusa H, Akagi T
- Journal Title
  
  Oncogene 24(36)
  
  Pages: 5648-5655
- Data Source
  KAKENHI-PROJECT-16002014
[Journal Article] Oncogenic transformation of human cells : shortcomings of roden model systems2004
- Author(s)
  Akagi, T.
- Journal Title
  
  Trends in Molecular Medicine 1011
  
  Pages: 542-548
- Data Source
  KAKENHI-PROJECT-15590358
[Journal Article] Human diploid fibroblasts are refractory to oncogene-mediated transformation2004
- Author(s)
  Akagi, T., Hanafusa, H.
- Journal Title
  
  Cell Cycle 3・3
  
  Pages: 257-258
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590358
[Journal Article] Human diploid fibroblasts are refractory to oncogene-mediated transformation.2004
- Author(s)
  Akagi T, Hanafusa H
- Journal Title
  
  Cell Cycle. 3(3)
  
  Pages: 257-258
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590358
[Journal Article] Human diploid fibroblasts are refractory to oncogene-madiated transformation2004
- Author(s)
  Akagi, T., Hanafusa, H.
- Journal Title
  
  Cell Cycle 3
  
  Pages: 257-258
- Data Source
  KAKENHI-PROJECT-16002014
[Journal Article] Oncogenic transformation of human cells-shortcomings of roden model systems2004
- Author(s)
  Akagi, T.
- Journal Title
  
  Trends in Molecular Medicine 1011
  
  Pages: 542-548
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590358
[Journal Article] CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas2004
- Author(s)
  Iwahara, T., Akagi, T., Fujitsuka, Y., Hanafusa, H.
- Journal Title
  
  Proc.Natl.Acad.Sci. U.S.A. 101・51
  
  Pages: 17693-17698
- Data Source
  KAKENHI-PROJECT-16002014
[Journal Article] Oncogenic transformation of human cells : shortcomings of rodent model systems.2004
- Author(s)
  Akagi T.
- Journal Title
  
  Trends in Molecular Medicine. 10(11)
  
  Pages: 542-548
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590358
[Journal Article] Loss of c-able facilitates anchorage-independent growth of p53- and RB-dificient primary mouse embryonic fibroblasts2004
- Author(s)
  Suzuki, J., Sukezane, T., Akagi, T., Hanafusa, H., Shishido, S., et al.
- Journal Title
  
  Oncogene 23
  
  Pages: 8527-8534
- Data Source
  KAKENHI-PROJECT-16002014
[Journal Article] Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation.2003
- Author(s)
  Akagi T, Sasai K, Hanafusa H.
- Journal Title
  
  Proc Natl Acad Sci USA. 100(23)
  
  Pages: 13567-13572
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590358
[Journal Article] Refractory nature of normal human diploid fibroblasts with respest to oncogene-mediated transformation2003
- Author(s)
  Akagi, T., Sasaki, K., Hanafusa, H.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 100・23
  
  Pages: 13567-13572
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590358
[Journal Article] Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation2003
- Author(s)
  Akagi, T., Sasai, K., Hanafusa, H.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 100・23
  
  Pages: 13567-13572
- Data Source
  KAKENHI-PROJECT-15590358

1. TANAKA Shinya (70261287)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. MINAMI Akio (20133738)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SAWA Hirofumi (30292006)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 菅村和夫 (20117360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 渡邊俊樹 (30182934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 内山卓 (80151900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 藤澤順一 (40181341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 藤井雅寛 (30183099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 吉木敬 (60220612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 花房秀三郎 (50312228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. 岩原寿典 (80332229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 小根山千歳 (90373208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 許南浩 (70173573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 野瀬清 (70012747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AKAGI Tsuyoshi 赤城 剛

赤城 剛 アカギ ツヨシ

Research Projects

Research Products

Co-Researchers

癌遺伝子による足場非依存性増殖能獲得のメカニズム

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒト正常繊維芽細胞のトランスフォーメーションに対する抵抗性の分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of human synovial sarcoma oncoprotein SYT-SSX and its therapeutic application.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of an efficient gene transfer system to normal epithelial cells and its application for cancer researchPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト正常細胞を用いた癌遺伝子の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of transforming mechanism of human synovial sarcoma oncogene SYT-SSX

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the mechanism of PI3K/AKT pathway activation by v-Crk oncogenePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HTLV-I感染T細胞で高発現しているp21^<Waf1/Cip1/SdiI>の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HTLV-1感染T細胞およびTax1導入T細胞における細胞周期関連遺伝子の発現Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HTLV-1による細胞がん化の分子機構

Principal Investigator

Project Period (FY)

Research Category

Research Institution

HTLV-1エンベロープタンパクのT細胞の増殖に対する影響Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HTLV-1 Tax遺伝子を導入したヒト正常リンパ球の増殖能の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

哺乳類O^6-アルキルグアニン修復酵素遺伝子のクローニング

Principal Investigator

Project Period (FY)

Research Category

AKAGI Tsuyoshi 赤城剛

赤城剛アカギツヨシ