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Koyama Yoshikazu  小山 芳一

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… Alternative Names

YOSHIKAZU Koyama  小山 芳一

KOYAMA Yoshikazu  小山 芳一

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Researcher Number 90186841
Other IDs
Affiliation (based on the past Project Information) *help 2012 – 2015: 北海学園大学, 工学部, 教授
2007 – 2008: 北海道情報大学, 経営情報学部, 教授
2006: Hokkaido University, Graduate School of Medicine, Instructor, 大学院医学研究科, 助手
2004 – 2005: Hokkaido University, Grad.School of Medicine, assistant professor, 大学院・医学研究科, 助手
2000 – 2001: 北海道大学, 医学研究科, 助手 … More
2000 – 2001: 北海道大学, 大学院・医学研究科, 助手
1998 – 1999: 北海道大学, 医学部, 助手
1994 – 1996: 北海道大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
General medical chemistry / Tumor immunology
Except Principal Investigator
Orthopaedic surgery / Biological Sciences / Pathological medical chemistry
Keywords
Principal Investigator
AFP / gene therapy / hepatoma / targetin vector / silencer / gene expression / transcription factor / 遺伝子療法 / 肝ガン / targeting vector … More / サイレンサー / 遺伝子発現 / 転写因子 / DNAワクチン / 発がん / MIF / IBD / 抗自己サイトカイン / ワクチン療法 … More
Except Principal Investigator
トランスジェニックマウス / α-フェトプロテイン / DNAワクチン / マクロファージ遊走阻止因子 / DNA vaccine / macrophage migration inhibitory factor / ATBF1 / サイトカイン / エンドトキシンショック / マクロファージ / MIF / 転写因子 / ovariectom / osteoporosis / リスクファクター / 遺伝子多型 / ノックアウトマウス / 卵巣摘出 / 骨粗鬆症 / rheumatoid arthritis / 慢性関節リウマチ / ワクチン / 関節リウマチ / transgenic mice / hepatocellular cacinoma / T-Cell / auto-imune doseases / immunosupression / α-fetoprotein / 自己免疫性甲状腺炎 / 免疫抑制能 / リュウマチ性関節炎 / ミエリン塩基性タンパク / 多発性硬化症 / 実験的アレルギー性骨髄炎(EAE) / 肝癌 / T細胞 / 自己免疫疾患 / 免疫抑制 / Cell growth control / Neuronal differentiation / Alternative splicing / Zn-finger structure / Homeotic-domain / Transcription factor / alpha-fetoprotein gene / 神経分化 / 選択的スプライシング / Zn- フィンガー / 細胞増殖 / 神経細胞分化 / 選択的スブライシング / Zn-フィンガー構造 / ホメオドメイン / α-フェトプロテイン遺伝子 / 骨吸収 / in vivoイメージング / in vivo イメージング / 骨溶解 / 磨耗粉 / 癌浸潤 / 血管新生 / レクチン / 免疫抑制活性 / がん性変化 / 実験的甲状腺炎 / 糖鎖 / 発生工学 / モノクロナル抗体 / エストロゲン結合能 / 不飽和脂肪酸 / Znフィンガー / レクチン親和電気泳動法 Less
  • Research Projects

    (11 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (19 People)
  •  Development of MIF vaccine therapy against inflammation-related colon carcinogenesisPrincipal Investigator

    • Principal Investigator
      Koyama Yoshikazu
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor immunology
    • Research Institution
      Hokkai-Gakuen University
  •  Role of MIF in wear particle-induced oeteolysis and its regulation by MIF-DNA vaccination

    • Principal Investigator
      ONODERA Shin
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Hokkaido University
  •  The pathomechanism of postmenopausal osteoporosis-the involvement of MIF and therapeutic approach using MIF-DNA vaccine

    • Principal Investigator
      ONODERA Shin
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Hokkaido University
  •  The development of MIF vaccine and its therapeutic effect on murine arthritis model

    • Principal Investigator
      ONODERA Shin
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Hokkaido University
  •  癌細胞浸潤及び血管新生におけるマクロファージ遊走阻止因子の機能に関する基礎的研究

    • Principal Investigator
      西平 順
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  癌細胞浸潤及び血管新生におけるマクロファージ遊走阻止因子の機能に関する基礎的研究

    • Principal Investigator
      西平 順
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Functional analysis of α-fetoprotein by genetically engineered mice

    • Principal Investigator
      NISHI Shinzo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Hokkaido University
  •  Analysis of Transcription Factors Involved in Liver Specific Gene Expression: Cloning of Silencer Binding ProteinPrincipal Investigator

    • Principal Investigator
      KOYAMA Yoshikazu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  発生工学を応用したα-フェトプロティンの糖鎖構造および機能の解析

    • Principal Investigator
      西 信三
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  α-フェトプロテインの構造、機能および発現の研究

    • Principal Investigator
      NISHI Shinzo
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  Studies on Multiple Homeodomain/Zn Finger ATBF1 Gene Family

    • Principal Investigator
      NISHI Shinzo
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Hokkaido University

All 2016 2013 2008 2007 2006 2004 Other

All Journal Article Presentation Patent

  • [Journal Article] A novel DNA vaccine targeting macrophage migration inhibitory factor improves the survival of mice with sepsis2008

    • Author(s)
      TohyamaS, Onodera S, Tohyama H, Yasuda K, Nishihira J, Mizue Y, Hamasaka A, Abe R, Koyama Y
    • Journal Title

      Gene Therapy 15(23)

      Pages: 1513-1522

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591746
  • [Journal Article] Active immunization against macrophage migration inhibitory factor using a novel DNA vaccine prevents ovariectomy-induced bone loss in mice2008

    • Author(s)
      Onodera S, Oshima S, Nishihira J, Yasuda K, Tohyama H, Irie K, Koyama Y
    • Journal Title

      Vaccine 26(6)

      Pages: 829-836

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591746
  • [Journal Article] A novel DNA vaccine targeting macrophage migration inhibitory factor protects joints from inflammation and destruction in murine models of arthritis.2007

    • Author(s)
      Onodera S, Oshima S, Tohyama H, Yasuda K, Nishihira J, Iwakura Y, Matsuda I, Minami A, Koyama Y
    • Journal Title

      Arthritis Rheum 56(2)

      Pages: 521-530

    • NAID

      40017099467

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591542
  • [Journal Article] Transgenic Mice Overexpressing Macrophage Migration Inhibitory Factor (MIF) Exhibit High-Turnover Osteoporosis.2006

    • Author(s)
      Onodera S, Sasaki S, Ohshima S, Amizuka N, Li M, Udagawa N, Irie K, Nishihira J, Koyama Y, Shiraishi A, Tohyama H, Yasuda K
    • Journal Title

      J Bone Min Res 21(6)

      Pages: 876-885

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591542
  • [Journal Article] Macrophage Migration Inhibitory Factor-Deficient Mice Are Resistant to Ovariectomy-Induced Bone Loss.2006

    • Author(s)
      Oshima S, Onodera S, Amizuka N, Li M, Irie K, Watanabe S, Koyama Y, Nishihira J, Yasuda K, Minami A
    • Journal Title

      FEBS Lett 580(5)

      Pages: 1251-6

    • NAID

      120000953646

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591542
  • [Journal Article] Macrophage Migration Inhibitory Factor (MIF) Up-regulates Expression of Interleukin (IL)-8 mRNA in Synovial Fibroblasts of Rheumatoid Arthritis ; Common Transcriptional Regulatory Mechanism between IL-8 and IL-1β.2004

    • Author(s)
      Onodera S, Nishihira J, Koyama Y, Majima T, Aoki Y, Ichiyama H, Ishibashi T, Minami A
    • Journal Title

      Arthritis Rheum 50

      Pages: 1437-1447

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591560
  • [Patent] DNAワクチン2004

    • Inventor(s)
      西平 順, 小山 芳一, 小野寺 伸
    • Industrial Property Rights Holder
      西平 順, 小山 芳一, 小野寺 伸
    • Industrial Property Number
      2004-280051
    • Filing Date
      2004-09-27
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591560
  • [Patent] DNAワクチン2004

    • Inventor(s)
      西平 順, 小山芳一, 小野寺 伸
    • Industrial Property Rights Holder
      西平 順, 小山芳一, 小野寺 伸
    • Industrial Property Number
      2004-280051
    • Filing Date
      2004-09-27
    • Data Source
      KAKENHI-PROJECT-15591560
  • [Presentation] Colonization of Staphylococcus aureus in the mucosal inflammatory area in the case of severe clinical bovine mastitis2016

    • Author(s)
      Yuya Nagasawa, Yoshio Kiku, Yoshikazu Koyama, Tomonori Nochi, Hisashi Aso, Tomohito Hayashi
    • Organizer
      World Buiatrics Congress
    • Place of Presentation
      Dublin
    • Year and Date
      2016-07-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24501332
  • [Presentation] Establishment of a new ELISA system for detection of total Staphylococcus aureus-specific antibodies in bovine milk2013

    • Author(s)
      Tomohito Hayashi, Yoshio Kiku, Fuyuko Tanabe, Kazue Sugawara, Eiji Hata, Kazuhiro Kawai and Yoshikazu Koyama
    • Organizer
      31st World Veterinary Congress
    • Place of Presentation
      Prague, Czech Republic
    • Invited
    • Data Source
      KAKENHI-PROJECT-24501332
  • [Presentation] DISTRIBUTION OF ACCESSORY GENE REGULATOR GROUPS IN STAPHYLOCOCCUS AUREUS ISOLATED FROM BOVINE MASTITIC MILK IN JAPAN

    • Author(s)
      Atsushi Watanabe, Yoshikazu Koyama, Eiji Hata, Ikuo Uchida, Yukio Chikayama, Yoshio Kiku, Tomohito Hayashi
    • Organizer
      CoVet 2014
    • Place of Presentation
      Prague, Czech
    • Year and Date
      2014-10-23 – 2014-10-26
    • Data Source
      KAKENHI-PROJECT-24501332
  • 1.  SAKAI Masaharu (50162269)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  NISHI Shinzo (20001894)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  ONODERA Shin (00359481)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 4.  西平 順 (30189302)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 5.  KAZUHARU Irie (70223352)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 6.  NAKABYASHI Hidekazu (10033383)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  岩渕 和也 (20184898)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  小林 正伸 (80241321)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  KATO Takuma (60224515)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SHIMA Tomoko (10172868)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  FURUYAMA Junichi (30068431)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  WATANABE Masahiko (70210945)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  松浦 栄次 (20181688)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  MUNRO Neville
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  MORINAGA Tomonori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  TAMAOKI Taiki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  エリオット アルバート
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  ELLIOT Alpert
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  中野 芳朗
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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