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SAKAI Masaharu  酒井 正春

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Researcher Number 50162269
External Links
Affiliation (based on the past Project Information) *help 2010: 北海道大学, 大学院・保健科学研究院
2008 – 2010: 北海道大学, 大学院・保健科学研究院, 教授
2007: 北海道大学, 医学部, 教授
2005: Hokkaido University, School of Medicine, Professor, 医学部, 教授
2004: 北海道大学, 大学院・医学研究科, 助教授 … More
2000 – 2001: 北海道大学, 大学院・医学研究科, 助教授
1992 – 1999: 北海道大学, 医学部, 助教授
1990 – 1991: 北海道大学, 医学部・生化学第1, 助教授
1989 – 1990: HOKKAIDO UNIVERSITY SCHOOL OF MEDICINE, ASSOCIATE PROFFESOR, 医学部, 助教授
1988: 北海道大学, (北大医第一生化), 講師
1988: 東京大学, 医学部, 助手
1986: 東京大学, 医学部, 助手
1986: 東京大学, 医学部生化学第一, 助手
1986: Faculty of Medicine, University of Tokyo, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / Molecular biology / General medical chemistry / Human pathology / General medical chemistry
Except Principal Investigator
General medical chemistry / Pathological medical chemistry / Risk sciences of radiation/Chemicals / Radiation science / Ophthalmology
Keywords
Principal Investigator
Maf / 転写因子 / Jun / PPAR / 癌遺伝子 / GST-P / Fos / グルココルチコイド / bZip構造 / 軟骨細胞 … More / 腫瘍マーカー / 転写調節 / 軟骨 / 水晶体 / グルタチオントランスフェラーゼP / 転写制御 / ラット肝発癌 / Glutathione transferase P / Rat hepatocarcinogenesis / 細胞分化 / Chondrocyte / C / DNA / cーJun関連遺伝子 / cーFos関連遺伝子 / GSTーP / ラットmaf関連遺伝子 / cDNAクローニング / グルタチオントランスフェラーゼP(GSFP) / GST-P遺伝子 / 転写因子Maf / DNA結合 / ヘテロ二量体 / ペルオキシソーム増殖剤 / クロフィブレート / ペルオキシソーム増殖剤受容体 / ラット肝化学発癌 / 肝化学発癌 / 遺伝子発現 / Glucocorticoide / Peroxisome proliferator / Regulation of transcription / NQO遺伝子 / グルタチオントランスフェラーゼP(GST-P) / maf関連遺伝子 / Tumor maker / Transcriptional control / 脊髄 / 腎臓 / 脂肪細胞 / Transcription factor / Oncogene / Differentiation / maf / Lens / Spinal code / Kidney / 結合組織増殖因子(CTGF) / EBPα / DNAマイクロアレー / 標的遺伝子 / ノックアウトマウス / Cellular differentiation / Transcription factors / CTGF / EBP / DNA micro-array / B型肝炎ウイルス(HBV) / HBV-DNA組込み / 肝癌 / 肝硬変 / 多中心性発生肝癌 / 肝細胞増生 / クローン / Hepatitis B virus (HBV) / HBV DNA integration / Hepatocellular carcinoma / Liver cirrhosis / Multicentric origin of hepatocellular carcinoma / ステロイドホルモン / エストロゲン受容体 / 人工欠失変異 / エストロゲン標的遺伝子 / 機能的ドメイン構造 / 遺伝子クロ-ニング / エストロゲン受容体の機能的ドメイン構造 / トランス作用活性 / DNA結合領域 / ステロイド結合領域 / 大腸菌による大量産生 / カイコ多角体病ウイルスベクター / STEROID HORMONE / ESTROGEN RECEPTOR / DELETION MUTANTS / ESTROGEN TARGET GENE / FUNCTIONAL DOMAIN STRUCTURE / GENE CLONING / TRANSCRIPTIONAL REGULATION … More
Except Principal Investigator
α-フェトプロテイン / 転写因子 / AFP / トランスジェニックマウス / 肝癌 / 遺伝子発現 / エンハンサー / 多段階発癌 / 癌関連遺伝子 / 発癌のプログレッション / マ-カ-酵素変異 / CEA / サイレンサー / 選択的スプライシング / 転写制御 / ATBF1 / c-fos / 免疫抑制 / 自己免疫疾患 / T細胞 / α-fetoprotein / auto-imune doseases / hepatocellular cacinoma / transgenic mice / GST-P / キメラ抗体 / 癌抗原 / 抗体複合体 / Mn-SOD / インスリン様増殖因子 / マンノース6リン酸 / 受容体 / 光親和標識 / 大腸癌抗原 / 糖転移酵素 / ミサイル療法 / ムチン抗原 / リポソーム / 腫瘍マーカー / レクチン親和電気泳動法 / Znフィンガー / 不飽和脂肪酸 / エストロゲン結合能 / モノクロナル抗体 / 発生工学 / 糖鎖 / 実験的甲状腺炎 / がん性変化 / 免疫抑制活性 / レクチン / 放射線作用機構 / 放射線照射 / DNA構成類似物質 / 電子線トラック解析 / 電子衝突断面積 / 電子スオーム法 / ATS実験 / 電離・励起衝突 / 細胞生存率曲線 / 放射線 / 量子ビーム / 生体高分子 / 電子スオームパラメータ / 放射線生物学 / irradiation / p16 / repopulation / mitosis / MMP / HIF1-alpha / radiation / cancer stem cell / cell movement / Radiotherapy / TGFB-1 / 細胞形態 / 細胞運動 / 発現調節 / 癌遺伝子 / cDNAクローニング / 異常発現 / DNase高感受性 / 癌細胞特異性 / 遺伝子転座 / GST-P遺伝子 / トランス作用因子 / GST-π / リボソ-ム遺伝子 / 真核生物 / UBF / クロ-ニング / スプライシング / HMGボックス / RNAポリメラ-ゼI / TFID / rDNA / プロモ-タ- / アフィニティ-カラム / キメラ遺伝子 / 種特異性 / マウス腹水肝癌 / RNAポリメラーゼI / プロモーター / フットプリント / α-フェトプロテイン遺伝子 / ホメオドメイン / Zn-フィンガー構造 / 選択的スブライシング / 神経細胞分化 / 細胞増殖 / Zn- フィンガー / 神経分化 / alpha-fetoprotein gene / Transcription factor / Homeotic-domain / Zn-finger structure / Alternative splicing / Neuronal differentiation / Cell growth control / gel shift assay / ロドプシン / 明暗環境 / mGluR6 / CREB / FOS蛋白 / 明暗変化 / 日内変動 / rhodopsin / transcription / light / promotor / targeting vector / 肝ガン / 遺伝子療法 / transcription factor / gene expression / silencer / targetin vector / hepatoma / gene therapy / 遺伝子 / 甲状腺炎 / Tリンパ球 / マイトジェン / immunosuperssion / T-cell / 実験的アレルギー性骨髄炎(EAE) / 多発性硬化症 / ミエリン塩基性タンパク / リュウマチ性関節炎 / 免疫抑制能 / 自己免疫性甲状腺炎 / immunosupression / T-Cell Less
  • Research Projects

    (26 results)
  • Research Products

    (9 results)
  • Co-Researchers

    (49 People)
  •  The secret of radiation-surviving cell : multidisciplinary approach to eradicate cancer

    • Principal Investigator
      NISHIOKA Takeshi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Hokkaido University
  •  Determination of electron collision cross sections of molecules in bio-cells aiming at the track analysis of ionizing radiations

    • Principal Investigator
      DATE Hiroyuki
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Hokkaido University
  •  Functions of the Maf transcription factors in development and differentiationPrincipal Investigator

    • Principal Investigator
      SAKAI Masaharu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Functional analysis of α-fetoprotein by genetically engineered mice

    • Principal Investigator
      NISHI Shinzo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Hokkaido University
  •  Transcriptional regulation of rhodopsin gene under light dark cycle

    • Principal Investigator
      MATSUDA Hidehiko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Ophthalmology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Analysis of Transcription Factors Involved in Liver Specific Gene Expression: Cloning of Silencer Binding Protein

    • Principal Investigator
      KOYAMA Yoshikazu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  The immunosuppressive function of the α-fetoprotein

    • Principal Investigator
      NISHI Shinzo
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Function of transcription factors mafs in the cellular differentiationPrincipal Investigator

    • Principal Investigator
      SAKAI Masaharu
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Molecular biology
    • Research Institution
      Hokkaido University
  •  発生工学を応用したα-フェトプロティンの糖鎖構造および機能の解析

    • Principal Investigator
      西 信三
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  癌遺伝子mafの標的遺伝子Principal Investigator

    • Principal Investigator
      酒井 正春
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  癌遺伝子mafの標的遺伝子Principal Investigator

    • Principal Investigator
      酒井 正春
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  α-フェトプロテインの構造、機能および発現の研究

    • Principal Investigator
      西 信三
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  Studies on Multiple Homeodomain/Zn Finger ATBF1 Gene Family

    • Principal Investigator
      NISHI Shinzo
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Hokkaido University
  •  The transcription factors regulate a tumor maker gene, Glutathione Transferase P.Principal Investigator

    • Principal Investigator
      SAKAI Masaharu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Hokkaido University
  •  腫瘍マーカーの基礎的臨床的研究

    • Principal Investigator
      西 信三
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  腫瘍マーカーの基礎的臨床的研究

    • Principal Investigator
      NISHI Shinzo
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  インスリン様増殖因子IIとその受容体の臨床応用

    • Principal Investigator
      賀佐 伸省
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Sapporo Medical University
  •  Regulation mechamism of gene expression on the early stage of carcinogenesis.Principal Investigator

    • Principal Investigator
      SAKAI Masaharu
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Hokkaido University
  •  多段階発癌過程における癌関連遺伝子の変化

    • Principal Investigator
      北川 知行
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research
  •  癌遺伝子Jun及びその関連遺伝子産物の転写調節、機能.Principal Investigator

    • Principal Investigator
      酒井 正春
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  多段階発癌過程における癌関連遺伝子の変化

    • Principal Investigator
      北川 知行
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research
  •  真核生物リボソ-ム遺伝子の発現制御機構

    • Principal Investigator
      村松 正實
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokyo
  •  STUDIES OF FUNCTIONAL DOMAIN STRUCTURE OF THE STEROID RECEPTOR AND CLONING OF RELATED GENES.Principal Investigator

    • Principal Investigator
      SAKAI Masaharu
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      HOKKAIDO UNIVERSITY
      The University of Tokyo
  •  化学発癌過程において活性化する遺伝子の探索

    • Principal Investigator
      村松 正実
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      The University of Tokyo
  •  癌化関連遺伝子の特異的形質発現機構および構造解析

    • Principal Investigator
      藤井 義明
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research
  •  Molecular biological study on the relationship between hepatitis B virus and hepatocellular carcinomaPrincipal Investigator

    • Principal Investigator
      SAKAI Masaharu, 青木 直人
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      University of Tokyo

All 2005 2004

All Journal Article Book

  • [Book] Methods in Enzymology vol.4012005

    • Author(s)
      Sakai M. et al.
    • Total Pages
      20
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PROJECT-16590215
  • [Journal Article] Regulation of GST-P gene expression during hepatocarcinogenesis.2005

    • Author(s)
      Sakai M., et al.
    • Journal Title

      Methods in Enz. 401

      Pages: 42-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590215
  • [Journal Article] Regulation of GST-P gene expression during hepatocarcinogenesis.2005

    • Author(s)
      Sakai.M.et al.
    • Journal Title

      Methods in Enzymology (Elsevier) vol. 401

      Pages: 20-20

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590215
  • [Journal Article] Regulation of GST-P gene expression during hepatocarcinogenesis2005

    • Author(s)
      Sakai, M., Muramatsu, M
    • Journal Title

      Methods in Enz. 389(in press)

    • Data Source
      KAKENHI-PROJECT-16590215
  • [Journal Article] Developmental contribution of c-maf in the kidney : distribution and developmental study of c-maf mRNA in normal mice kidney and histological study of c-maf knock out mice kidney and liver2004

    • Author(s)
      Imaki J, Tsuchiya K, Mishima T, Onodera H, Kim JI, Yoshida K, Ikeda H, Sakai M
    • Journal Title

      Biochem Biophys Res Commnun. 320

      Pages: 1323-1327

    • Data Source
      KAKENHI-PROJECT-16590215
  • [Journal Article] Expression of c-maf and mafB genes in the skin during rat embryonic development2004

    • Author(s)
      Ogata A, Shimizu T, Abe R, Shimizu H, Sakai M.
    • Journal Title

      Acta histochemica 106

      Pages: 65-67

    • Data Source
      KAKENHI-PROJECT-16590215
  • [Journal Article] Expreasion of maf-B mRNA in the epithelium around the eyelid closure of the mouse eye at embryonic day 182004

    • Author(s)
      Kase S, Imaki J, Harada T, Harada C, Ohgami K, Shiratori K, Sakai M, Nishi S, Ohno S. Yoshida K
    • Journal Title

      Anat Embryol 209・2

      Pages: 153-156

    • Data Source
      KAKENHI-PROJECT-16590215
  • [Journal Article] Functional mapping of tissue-specific elements of the human alpha-fetoprotein gene enhancer.2004

    • Author(s)
      Nakabayashi H, Koyama Y, Suzuki H, Li HM, Sakai M, Miura Y, Wong NC, Niahi S
    • Journal Title

      Biochem Biophys Res Commun 318

      Pages: 773-785

    • Data Source
      KAKENHI-PROJECT-16590215
  • [Journal Article] Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis2004

    • Author(s)
      Ikeda, H., Nishi, S., Sakai, M.
    • Journal Title

      Biochemical J 380

      Pages: 515-521

    • Data Source
      KAKENHI-PROJECT-16590215
  • 1.  NISHI Shinzo (20001894)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 2.  KOYAMA Yoshikazu (90186841)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  NAKABYASHI Hidekazu (10033383)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  村松 正実 (10035454)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  IMAKI Junko (20223323)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  AOKI Naoto (20159289)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  北川 知行 (50085619)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  白井 智之 (60080066)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  広橋 説雄 (70129625)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  佐藤 清美 (50006079)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  小川 勝洋 (50045514)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  武田 和久 (50033080)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  谷口 直之 (90002188)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  高橋 俊雄 (50079828)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  高橋 直樹 (30179501)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  DATE Hiroyuki (10197600)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  HASEGAWA Hirokazu (20106131)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  NISHIOKA Takeshi (80271659)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  YASUDA Motoaki (90239765)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  HAGA Hisahi (00292045)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  TUTSMI Kaori (80344505)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  HOMMA Akiniro (30312359)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  SHIMA Tomoko (10172868)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  FURUYAMA Junichi (30068431)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  WATANABE Masahiko (70210945)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  MATSUDA Hidehiko (80000959)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  YOSHIDA Kazuhiko (90281807)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  KOYAMA Yoshikazu (90106041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  AOYAMA Hiromu (50167805)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  IMAKADO Sumihisa (60168507)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  谷内 昭 (50045324)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  賀佐 伸省 (10142712)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  小路 敏彦 (20039811)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  松浦 栄次 (20181688)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  藤井 義明 (00098146)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  黒沢 良和 (10109259)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  喜多村 直実 (80107424)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  西村 暹 (20076970)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  遠藤 英也 (40037320)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  西村 哲治 (20156110)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  今川 正良 (20136823)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  加藤 宏幸 (60185866)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  MUNRO Neville
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  MORINAGA Tomonori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  TAMAOKI Taiki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  エリオット アルバート
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  ELLIOT Alpert
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  中野 芳朗
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  近藤 滋
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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