Wada Takeshi 和田猛

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WADA TAKESHI 和田猛

WADA Takeshi 和田猛

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Researcher Number	90240548
Other IDs
External Links
Affiliation (Current)	2025: 東京理科大学, 薬学部生命創薬科学科, 教授
Affiliation (based on the past Project Information) *help	2015 – 2024: 東京理科大学, 薬学部生命創薬科学科, 教授 2013: 東京理科大学, 薬学部, 教授 2012: 東京大学, 新領域創成科学研究科, 准教授 2009 – 2011: The University of Tokyo, 大学院・新領域創成科学研究科, 准教授 2009: 東京大学, 新領域創成科学研究科, 准教授 … More 2007: The University of Tokyo, Graduate School of Frontier Sciences, Associate Professor 2006: 東京大学, 新領域創成科学研究科, 助教授 2002 – 2005: 東京大学, 大学院・新領域創成科学研究科, 助教授 2004: The University of Tokyo, Graduate School of Frontier Sciences, Associate Professor, 大学院新領域創成科学研究科, 助教授 2001: 東京大学, 大学院・新領域創性科学研究科, 助教授 2001: 東京大学, 新領域創成科学研究科, 助教授 1999 – 2000: 東京大学, 大学院・新領域創成科学研究科, 助教授 1992 – 1998: 東京工業大学, 生命理工学部, 助手 1994: TOKYO INSTITUTE OF TECHNOLOGY,FACULTY OF BIOSCIENCE AND BIOTECHNOLOGY,RESEARCH A Less
Review Section/Research Field	Principal Investigator Bioorganic chemistry / Biological Sciences / Chemistry related to living body / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Bio-related chemistry / Science and Engineering / Biological Sciences Except Principal Investigator Basic Section 53010:Gastroenterology-related / Medical sociology / 広領域 … More / Bioorganic chemistry / Molecular biology / 天然物有機化学 / Biological Sciences Less
Keywords	Principal Investigator アンチセンス核酸 / 保護基 / 核酸医薬 / 固相合成 / 不斉合成 / DNAアナログ / siRNA / mRNA / H-ホスホネートDNA / 立体選択的合成 … More / RNAi / リン原子修飾核酸 / 立体制御 / ホスホロチオエートRNA / ボラノホスフェートDNA / エイズウイルス / 水酸基選択的ホスホリル化 / RNA合成 / solid-phase synthesis / ホスホロアミダイト法 / 人工核酸 / ホスホロチオエートDNA / オキサザホスホリジン法 / 核酸合成 / 化学修飾核酸 / microRNA / ボラノホスフェートRNA / tRNA / RNA / 修飾塩基 / ^<31>P-NMR / DNA合成 / ボラノホスフェート核酸 / 分子選択 / ホスホロチオエート核酸 / nucleic acid analogs / automated synthesis / nucleic acid drugs / 2'-O-protecting group / RNA synthesis / ルイス酸 / 位置選択的ホスフィチル化 / 官能基選択的ホスフィチル化 / ホスファイト / グリーンケミストリー / 固相合成法 / フルオラス溶媒 / フルオラス合成法 / リン原子就職核酸 / 脱水縮合剤 / 液相合成 / 大量合成 / オリゴヌクレオチド / RNA類縁体 / 自動合成 / condensing reagent / PNA / peptide nucleic acid / L-serine / polyester / artificial nucleic acid / nucleic acid analog / チミン / 分子内環化反応 / 光学活性セリン / ラセミ化 / 光学活性化合物 / 脱水縮合反応 / 核酸類縁ポリエステル / Oligonucleotide therapeutics / Solid-phase synthesis / Oligonucleotide synthesis / Stereocontrolled synthesis / Artificial nucleic acids / Antisense DNA / Phosphorothioate DAN / Boranophosphate DNA / タンパク質相互作用 / RNA相互作用 / DNA相互作用 / DNA / 2-アジドデオキシアデノシン / 光クロスリンク核酸 / N-アシル化DNA / 無保護H-ホスホネート法 / ジアステレオ選択的合成 / ホスホロシオエートDNA / オキサザホスホリジシ法 / 機能性核酸 / H-ホスホネート / 2'-0-メチルリボヌクレオシド / 光学活性ホスホロチオエート / DDS / ホスホロチオーエートRNA / がん / 非コードRNA / Nefタンパク質 / HIV / エイズ / Nef / τm^5s^2U / τm^5U / ミトコンドリア病 / ミトコンドリア / ホスホリル化 / ホスホニル化 / 分子内触媒 / ニコチンアミド / アデノシン / ADPリボシル化 / インシュリン / NAD / カルシウム貯蔵 / カルシウムイオン放出 / 環状ADPリボース … More Except Principal Investigator RNA / SOLID PHASE SYNTHESIS / ANTISENCE NUCLEIC ACID / HIV / 核酸製剤 / 浸潤・転移 / 膵癌 / AMIDITE / ENZYME RESISTANCE / 2'-PHOSPHATE / アンチセンス核酸 / 新規創薬 / 核酸治療 / デリバリーシステム / 核酸化合物 / 創薬 / RNA干渉 / 医薬品比較システム / 医薬品情報提供 / 処方支援 / 医薬品情報提供アプローチ / 医薬品比較 / 基礎薬学の臨床活用 / 医薬品情報データベース / 医薬品特性比較 / 能動的医薬品情報提供 / 処方最適化 / アカデミック・ディテーラー / 医薬品特性比較データベース / 基礎薬学臨床活用 / 臨床薬剤師 / 医薬品情報リテラシー / アカデミック・ディテーリング / U1 RNA / 2-AZIDODEOXYADENOSINE / SOLID PHASE / PHOTOCROSSLINKING / TRANSFER RNA SYNTHESIS / SYNTHETIC / MODIFIED RNA / ANTISENCE NUCLEIC ACID RNA / 縮合反応 / ホスホネート法 / アミダイト法 / 6-チオグアノシン / 6-チオイノシン / 4-チオウリジン / U1RNA / 2-アジドデオイシアデノシン / 固相合成 / 光クロスリンク / tRNA / 合成RNA / 修飾RNA / DUPLEX FORMATION / MOLECULAR MECHANICS / INTRAMOLECULAR CYCLIZATION / CYCLOURIDYLIC ACID / 3'-ENDO / CONFORMATION / H-ホスホネートDNA / 分子内水素結合 / 遺伝子治療 / シクロヌクレオチド / 3′-endo / 二重らせん形成 / 固相合成法 / 分子力場計算 / 分子内環状化反応 / シクロウリジル酸 / 3'-endo / コンホメーション / アンチセンス / CHEMICAL SYNTHESIS / リンカー / ジホスフェート / リン酸化 / 塩基配列決定法 / 標識 / ビオチン / 化学発光 / CHEMICALSYNTHESIS / チオリン酸基 / 2'、3'-リン酸基転移 / 保護基 / 環状シリルエーテル / エイズ / アミダイト試薬 / 2'-リン酸化RNA / 酸素耐性 / アミダイト / 酵素耐性 / 固相法 / 化学合成 / 2'-リン酸 / アンチ核酸 / ゲノム / 蛋白質 / 核酸 / 発現制御 / 遺伝子 Less

Development of sterically controlled boranophosphate nucleic acid drugs with both high potency and low toxicityPrincipal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tokyo University of Science
Development of novel nucleic acid compounds for pancreatic cancer which inhibit the invasiveness and metastasis
- Principal Investigator
  
  Taniuchi Keisuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kochi University
膵癌治療への実用化を目指した新規核酸化合物のマウスモデルを用いた作用機序の検討
- Principal Investigator
  
  坪井麻記子
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kochi University
Research on development of drug comparison system and academic detailing effect using it
- Principal Investigator
  
  Komoda Masayo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical sociology
- Research Institution
  Tokyo University of Science
Molecule selection and optimization of highly active antisense DNA and determination of absolute configuration of phosphorus atomsPrincipal Investigator
- Principal Investigator
  
  WADA TAKESHI
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Tokyo University of Science
Functional machinery for non-coding RNAs
- Principal Investigator
  
  TOMARI Yukihide
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Medicinal Application of Functional Machinery for non-coding RNAsPrincipal Investigator
- Principal Investigator
  
  WADA Takeshi
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Science
  The University of Tokyo
Stereocontrolled synthesis of P-modified RNA nucleic acid drugsPrincipal Investigator
- Principal Investigator
  
  WADA Takeshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  The University of Tokyo
New synthetic methods for the large scale synthesis of nucleic acid drugsPrincipal Investigator
- Principal Investigator
  
  WADA Takeshi
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  The University of Tokyo
Synthesis and properties of novel artificial nucleic acid analogs having chiral backbonesPrincipal Investigator
- Principal Investigator
  
  WADA Takeshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  The University of Tokyo
ボラノホスフェートDNAを用いるHIV-nefタンパク質の発現制御Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Highly Efficient Synthesis of Artificial Nucleic Acids Having New FunctionsPrincipal Investigator
- Principal Investigator
  
  WADA Takeshi
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
修飾塩基を含むRNAの化学合成Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
新規アンチセンス核酸を用いるHIV-nefタンパク質の発現制御Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
修飾塩基を含むRNAの化学合成および構造と機能の探索Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
新規アンチセンス核酸を用いるエイズウイルス遺伝子の発現制御Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
官能基選択的ホスホリル化反応を用いる機能性核酸の分子構築Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tokyo Institute of Technology
エイズウイルス遺伝子を標的とした新規アンチセンス核酸のマルチ固相合成Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
アミノ基・リン酸基無保護法による新規アンチセンス核酸の分子構築Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tokyo Institute of Technology
MOLECULAR DESIGN OF NEW EFFECTIVE ANTISENSE NUCLEIC ACIDS CAPABLE OF HYBRIDIZATION TO THE TARGET NENES
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
DEVELOPMENTS OF THE METHOD FOR THE CHEMICAL SYNTHESIS OF RNA CONTAINING MODIFIED BASED" -DIRECTED TOWARD FULL AUTOMATION OF RNA CONTAINING MODIFIED BASES BY USE OF NEW SYNTHETIC UNITS-
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  広領域
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
超高速DNA/RNA化学合成法の開発-酵素反応にせまる効率的核酸合成反応-Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tokyo Institute of Technology
環状ADPリボースの化学合成-イオン輸送のカギを握る新しい情報伝達分子-Principal Investigator
- Principal Investigator
  
  和田猛
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Tokyo Institute of Technology
CHEMICAL SYNTHESIS OF A NEW MATERIAL OF ANTISENSE NUCLEIC ACID "2'-PHOSPHORYLATED RNAS" -DIRECTED TOWARD ITS BASIC STRUCTURAL STUDIES AND REGULATION OF EXPRESSION OF HIV VIRUS-
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Molecular biology
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
CHEMICAL SYNTHESIS OF A NEW MATERIAL OF ANTISENSE NUCLEIC ACID"2"PHOSTHORYLATEDRNAS" DIRETED TOWARD IIS BASIC STRUCTRAL STUDIES AND REGULATION OF EXPRESSION OF HIV VIRUS-
- Principal Investigator
  
  SEKINE Mitsuo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  天然物有機化学
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY

[Book] 核酸医薬の創製と応用展開《普及版》2022
- Author(s)
  和田猛
- Total Pages
  278
- Publisher
  シーエムシー出版
- ISBN
  9784781316406
- Data Source
  KAKENHI-PROJECT-23K21353
[Book] Synthesis of Therapeutic Oligonucleotides2018
- Author(s)
  Takeshi Wada, Yohei Nukaga (Satoshi Obika, Mitsuo Sekine Eds.)
- Total Pages
  284
- Publisher
  Springer
- ISBN
  9789811319129
- Data Source
  KAKENHI-PROJECT-15H03839
[Book] 中分子創薬に資するペプチド・核酸・糖鎖の合成技術2018
- Author(s)
  和田猛、他
- Total Pages
  317
- Publisher
  シーエムシー出版
- ISBN
- Data Source
  KAKENHI-PROJECT-15H03839
[Book] 核酸医薬への有機合成化学的アプローチ2016
- Author(s)
  和田猛
- Total Pages
  278
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-15H03839
[Book] 複合糖質の化学と最新応用技術《普及版》2015
- Author(s)
  和田猛
- Total Pages
  298
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-15H03839
[Book] RNA工学の基礎と応用2011
- Author(s)
  和田猛, 他
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-21350088
[Book] 10. RNA工学の基礎と応用2010
- Author(s)
  和田猛(共著)
- Publisher
  CMC出版
- Data Source
  KAKENHI-PLANNED-21115008
[Book] フルオラスケミストリーの基礎と応用2010
- Author(s)
  和田猛(共著)
- Publisher
  CMC出版
- Data Source
  KAKENHI-PLANNED-21115008
[Book] 核酸医薬の最前線2009
- Author(s)
  和田猛(監修), 他
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-21350088
[Book] フルオラスケミストリー2007
- Author(s)
  和田猛(共著)
- Total Pages
  8
- Publisher
  シーエムシー出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Properties of artificial cationic oligodiaminosaccharides and oligopeptides that bind to A-type oligonucleotide duplexes2023
- Author(s)
  Shiraishi Tomomi、Sato Kazuki、Hara Rintaro Iwata、Wada Takeshi
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids
  
  Volume: - Issue: 8 Pages: 1-18
- DOI
  10.1080/15257770.2023.2182444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21353
[Journal Article] Development of a new synthetic method for oligodeoxynucleotides using 3′-<i>H</i>-phosphonamidate derivatives2023
- Author(s)
  Tsurusaki Taiki、Sato Kazuki、Wada Takeshi
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 21 Issue: 12 Pages: 2486-2492
- DOI
  10.1039/d2ob02292c
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21353
[Journal Article] Fucosylated heparan sulfate from the midgut gland of Patinopecten yessoensis2023
- Author(s)
  Onishi Shoichi、Shionoya Kento、Sato Kazuki、Mubuchi Ayumu、Maruyama Shiori、Nakajima Tadaaki、Komeno Masahiro、Miyata Shinji、Yoshizawa Kazumi、Wada Takeshi、Linhardt Robert J.、Toida Toshihiko、Higashi Kyohei
- Journal Title
  
  Carbohydrate Polymers
  
  Volume: 313 Pages: 120847-120847
- DOI
  10.1016/j.carbpol.2023.120847
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05681, KAKENHI-PROJECT-23K21353, KAKENHI-PROJECT-23KJ0872
[Journal Article] Solid-phase synthesis and properties of stereocontrolled boranophosphate/phosphate and phosphorothioate/phosphate chimeric oligouridylates2023
- Author(s)
  Sato Kazuki、Nukaga Yohei、Wada Takeshi
- Journal Title
  
  Royal Society Open Science
  
  Volume: 10 Issue: 4
- DOI
  10.1098/rsos.230095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21353
[Journal Article] New Molecular Technologies for Oligonucleotide Therapeutics-2: A-Type Nucleic Acid Duplex-Specific Binding Oligocationic Molecules for Oligonucleotide Therapeutics2022
- Author(s)
  Hara Rintaro Iwata、Wada Takeshi
- Journal Title
  
  Springer
  
  Volume: - Pages: 1-13
- DOI
  10.1007/978-981-16-1313-5_103-1
- ISBN
  9789811613135
- Open Access
- Data Source
  KAKENHI-PROJECT-23K21353
[Journal Article] Solid-Phase Synthesis of Boranophosphate/Phosphorothioate/Phosphate Chimeric Oligonucleotides and Their Potential as Antisense Oligonucleotides.2022
- Author(s)
  Takahashi Y, Sato K, Wada T.
- Journal Title
  
  J Org Chem
  
  Volume: 87 Issue: 6 Pages: 3895-3909
- DOI
  10.1021/acs.joc.1c01812
- Data Source
  KAKENHI-PROJECT-20K08359
[Journal Article] Synthesis and properties of oligodiaminogalactoses that bind to A-type oligonucleotide duplexes2022
- Author(s)
  Shiraishi Tomomi、Sato Kazuki、Hara Rintaro Iwata、Wada Takeshi
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 20 Issue: 42 Pages: 8243-8258
- DOI
  10.1039/d2ob01575g
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21353
[Journal Article] Identification and Quantitative Analysis of 2-Fluoromethamphetamine and Its Metabolites in Human Urine2022
- Author(s)
  Ishii Ayumu、Sato Kazuki、Kusakabe Kosuke、Kato Noriyuki、Wada Takeshi
- Journal Title
  
  Journal of Analytical Toxicology
  
  Volume: 47 Issue: 1 Pages: 59-65
- DOI
  10.1093/jat/bkac026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21353
[Journal Article] Solid-phase synthesis of N-trichloroacetyl mannosamine 1-phosphate repeating units mimicking capsular polysaccharide derived from Neisseria meningitidis serotype A2022
- Author(s)
  Sato Kazuki、Chiba Akie、Shiraishi Tomomi、Ogawa Yuki、Hara Rintaro Iwata、Wada Takeshi
- Journal Title
  
  Carbohydrate Research
  
  Volume: 518 Pages: 108585-108585
- DOI
  10.1016/j.carres.2022.108585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21353
[Journal Article] New Molecular Technologies for Oligonucleotide Therapeutics-1: Properties and Synthesis of Boranophosphate DNAs2022
- Author(s)
  Sato Kazuki、Wada Takeshi
- Journal Title
  
  Springer
  
  Volume: - Pages: 1-20
- DOI
  10.1007/978-981-16-1313-5_73-1
- ISBN
  9789811613135
- Open Access
- Data Source
  KAKENHI-PROJECT-23K21353
[Journal Article] Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide2021
- Author(s)
  Rintaro Iwata Hara, Takeshi Wada
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 19 Issue: 31 Pages: 6865-6870
- DOI
  10.1039/d1ob00983d
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06993, KAKENHI-PROJECT-23K21353
[Journal Article] Solution-phase synthesis of oligodeoxyribonucleotides using the H-phosphonate method with N-unprotected 5′-phosphite monomers2021
- Author(s)
  Matsuda Hiromasa, Yoshida Erina, Shinoda Takaaki, Sato Kazuki, Hara Rintaro Iwata, Wada Takeshi
- Journal Title
  
  RSC Adv.
  
  Volume: 11 Issue: 60 Pages: 38094-38107
- DOI
  10.1039/d1ra06619f
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21353
[Journal Article] Solid-Phase Stereocontrolled Synthesis of Oligomeric P-Modified Glycosyl Phosphate Derivatives Using the Oxazaphospholidine Method2021
- Author(s)
  Sato Kazuki, Hagio Tomoya, Sano Michi, Muramoto Kazumasa, Yaoita Aya, Noro Mihoko, Hara Rintaro Iwata, Wada Takeshi
- Journal Title
  
  ACS Omega
  
  Volume: 6 Issue: 30 Pages: 20026-20041
- DOI
  10.1021/acsomega.1c03058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21353
[Journal Article] Solid-phase synthesis of oligouridine boranophosphates using the H-boranophosphonate method with 2′-O-(2-cyanoethoxymethyl) protection2021
- Author(s)
  Matsuda Hiromasa, Ito Hiroaki, Nukaga Yohei, Uehara Sho, Sato Kazuki, Hara Rintaro Iwata, Wada Takeshi
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 87 Pages: 153526-153526
- DOI
  10.1016/j.tetlet.2021.153526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21353
[Journal Article] Synthesis of thioamides from thiocarboxylic acids using phosphonium-type condensing reagents2021
- Author(s)
  Suzuki Ayaka, Takagi Kazunori, Sato Kazuki, Wada Takeshi
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 75 Pages: 153179-153179
- DOI
  10.1016/j.tetlet.2021.153179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21353
[Journal Article] Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.2021
- Author(s)
  Nagata T, Dwyer CA, Yoshida-Tanaka K, Ihara K, Ohyagi M, Kaburagi H, Miyata H, Ebihara S, Yoshioka K, Ishii T, Miyata K, Miyata K, Powers B, Igari T, Yamamoto S, Arimura N, Hirabayashi H, Uchihara T, Hara RI, Wada T, Bennett CF, Seth PP, Rigo F, Yokota T
- Journal Title
  
  Nat Biotechnol
  
  Volume: 39 Issue: 12 Pages: 1529-1536
- DOI
  10.1038/s41587-021-00972-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03555, KAKENHI-PROJECT-21H02909, KAKENHI-PROJECT-23K21353, KAKENHI-PROJECT-17H06109, KAKENHI-PROJECT-19H01016
[Journal Article] Highly efficient silencing of microRNA by heteroduplex oligonucleotides2019
- Author(s)
  Yoshioka Kotaro、Kunieda Taiki、Asami Yutaro、Guo Huijia、Miyata Haruka、Yoshida-Tanaka Kie、Sujino Yumiko、Piao Wenying、Kuwahara Hiroya、Nishina Kazutaka、Hara Rintaro Iwata、Nagata Tetsuya、Wada Takeshi、Obika Satoshi、Yokota Takanori
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 47 Issue: 14 Pages: 7321-7332
- DOI
  10.1093/nar/gkz492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] Trauma‐induced coagulopathy: The past, present, and future: A comment2019
- Author(s)
  Wada Takeshi、Yamakawa Kazuma
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 17 Issue: 9 Pages: 1571-1574
- DOI
  10.1111/jth.14571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] Disseminated intravascular coagulation in cardiac arrest and resuscitation2019
- Author(s)
  Gando Satoshi、Wada Takeshi
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 17 Issue: 8 Pages: 1205-1216
- DOI
  10.1111/jth.14480
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08933, KAKENHI-PROJECT-17H04361
[Journal Article] 本邦初アカデミック・ディテーリング教育プログラム開発-;基礎を臨床につなぐPBL チュートリアル-2019
- Author(s)
  小茂田　昌代, 和田　猛, 高橋　秀依, 嶋田　修治, 真野　泰成, 鈴木　立紀, 高澤　涼子, 尾関　理恵, 青山　隆夫
- Journal Title
  
  アプライド・セラピューティクス
  
  Volume: 11 Pages: 46-51
- NAID
  130007629768
- Open Access
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] リン原子の立体化学を厳密に制御したリン原子修飾核酸医薬の開発2019
- Author(s)
  6.和田猛
- Journal Title
  
  日本核酸医薬学会誌
  
  Volume: 23(1) Pages: 4-11
- NAID
  40022467013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] リン原子の立体化学を制御した核酸医薬の開発2019
- Author(s)
  和田猛
- Journal Title
  
  Medical Science Digest
  
  Volume: 45 Pages: 67-71
- Data Source
  KAKENHI-PROJECT-15H03839
[Journal Article] 化学構造式から見たアカデミック・ディテーリング2019
- Author(s)
  7.和田猛
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 139(8) Pages: 1101-1105
- NAID
  130007686239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] Sepsis-associated disseminated intravascular coagulation and its differential diagnoses2019
- Author(s)
  Iba Toshiaki、Japanese Surviving Sepsis Campaign Guideline Working Group for disseminated intravascular coagulation、Watanabe Eizo、Umemura Yutaka、Wada Takeshi、Hayashida Kei、Kushimoto Shigeki、Wada Hideo
- Journal Title
  
  Journal of Intensive Care
  
  Volume: 7 Issue: 1 Pages: 223-232
- DOI
  10.1186/s40560-019-0387-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] リン原子の立体化学を厳密に制御したリン原子修飾核酸医薬の開発2019
- Author(s)
  和田猛
- Journal Title
  
  医薬ジャーナル
  
  Volume: 55 Pages: 75-81
- NAID
  40022467013
- Data Source
  KAKENHI-PROJECT-15H03839
[Journal Article] Altered monocyte and NK cell phenotypes correlate with posttrauma infection2019
- Author(s)
  Seshadri Anupamaa、Brat Gabriel A.、Yorkgitis Brian K.、Giangola Matt、Keegan Joshua、Nguyen Jennifer P.、Li Wei、Nakahori Yasutaka、Wada Takeshi、Hauser Carl、Salim Ali、Askari Reza、Lederer James A.
- Journal Title
  
  Journal of Trauma and Acute Care Surgery
  
  Volume: 87 Issue: 2 Pages: 337-341
- DOI
  10.1097/ta.0000000000002264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] Solid-Phase Synthesis of Oligopeptides Containing Sterically Hindered Amino Acids on Nonswellable Resin Using 3-Nitro-1,2,4-triazol-1-yl-tris(pyrrolidin-1-yl)phosphonium Hexafluorophosphate (PyNTP) as the Condensing Reagent2018
- Author(s)
  Hara Rintaro Iwata、Mitsuhashi Yuta、Saito Keita、Maeda Yusuke、Wada Takeshi
- Journal Title
  
  ACS Combinatorial Science
  
  Volume: 20 Issue: 3 Pages: 132-136
- DOI
  10.1021/acscombsci.7b00184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08933, KAKENHI-PROJECT-15H03839
[Journal Article] Artificial cationic peptides that increase nuclease resistance of siRNA without disturbing RNAi activity2018
- Author(s)
  Yusuke Maeda, Rintaro Iwata Haraa, Kazutaka Nishina, Kie Yoshida-Tanaka, Taiichi Sakamoto, Takanori Yokota, Takeshi Wada
- Journal Title
  
  Nucleosides Nucleotides & Nucleic Acids
  
  Volume: 38 Issue: 5 Pages: 338-348
- DOI
  10.1080/15257770.2018.1543890
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03839
[Journal Article] Solid-Phase Synthesis of Fluorinated Analogues of Glycosyl 1-Phosphate Repeating Structures from Leishmania using the Phosphoramidite Method2018
- Author(s)
  Rintaro Iwata Hara, Aya Yaoita, Katsuya Takeda,Hiroaki Ueki, Ayumu Ishii, Hideyuki Imoto, Satoshi Kobayashi,Michi Sano, Mihoko Noro, Kazuki Sato, Takeshi Wada
- Journal Title
  
  ChemistryOpen
  
  Volume: 7 Issue: 6 Pages: 439-446
- DOI
  10.1002/open.201800030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H03839
[Journal Article] Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides2018
- Author(s)
  Rintaro Iwata Hara, Yusuke Maeda, Haruna Fujimaki and Takeshi Wada
- Journal Title
  
  Chemical Communications
  
  Volume: 54 Issue: 61 Pages: 5826-5829
- DOI
  10.1039/c8cc04082f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03839
[Journal Article] Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs2018
- Author(s)
  Rintaro Iwata Hara, Yuki Hisada, Yusuke Maeda, Takanori Yokota, Takeshi Wada
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 4323-4323
- DOI
  10.1038/s41598-018-22161-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08933, KAKENHI-PROJECT-15K17886, KAKENHI-PROJECT-15H03839
[Journal Article] Double-stranded RNA-binding artificial cationic oligosaccharides stabilizing siRNAs with a low N/P ratio2017
- Author(s)
  Hara, R. I., Maeda, Y., Sakamoto, T., Wada, T.
- Journal Title
  
  ORGANIC & BIOMOLECULAR CHEMISTRY
  
  Volume: 15 Issue: 7 Pages: 1710-1717
- DOI
  10.1039/c6ob02690g
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H03839
[Journal Article] Stereocontrolled Synthesis of P-Modified N-Acetylmannosamine-α-1-phosphate Analogs2017
- Author(s)
  Hara Rintaro Iwata、Ogawa Yuki、Noro Mihoko、Wada Takeshi
- Journal Title
  
  Chemistry Letters
  
  Volume: 46 Issue: 7 Pages: 1051-1053
- DOI
  10.1246/cl.170349
- NAID
  130005709494
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08933, KAKENHI-PROJECT-15H03839
[Journal Article] Synthesis and properties of 2-deoxy-2-fluoromannosyl phosphate derivatives2017
- Author(s)
  Hara Rintaro Iwata、Kobayashi Satoshi、Noro Mihoko、Sato Kazuki、Wada Takeshi
- Journal Title
  
  Tetrahedron
  
  Volume: 73 Issue: 31 Pages: 4560-4565
- DOI
  10.1016/j.tet.2017.06.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08933, KAKENHI-PROJECT-15H03839
[Journal Article] 薬として働く人工生体分子の合成2017
- Author(s)
  和田　猛
- Journal Title
  
  理大科学フォーラム
  
  Volume: 6 Pages: 26-27
- Data Source
  KAKENHI-PROJECT-17K08933
[Journal Article] Synthesis of 2′-O-monohaloethoxymethyl-modified RNAs and their duplex formation ability2017
- Author(s)
  Hara Rintaro Iwata、Kageyama Masayuki、Arai Koichiro、Uchiyama Naoki、Wada Takeshi
- Journal Title
  
  RSC Advances
  
  Volume: 7 Issue: 65 Pages: 41297-41303
- DOI
  10.1039/c7ra07767j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08933, KAKENHI-PROJECT-15H03839
[Journal Article] 核酸医薬への化学的アプローチ2016
- Author(s)
  和田猛
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 26 Pages: 18-21
- NAID
  130007388019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H03839
[Journal Article] One-pot conversion reactions of glycosyl boranophosphates into glycosyl phosphate derivatives via acyl phosphite intermediates2016
- Author(s)
  Sato, K., Wada. T
- Journal Title
  
  ORGANIC & BIOMOLECULAR CHEMISTRY
  
  Volume: 14 Issue: 47 Pages: 11092-11095
- DOI
  10.1039/c6ob02309f
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H03839
[Journal Article] リン原子修飾オリゴ核酸の立体選択的合成2016
- Author(s)
  和田猛、岡夏央
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 74 Pages: 31-44
- NAID
  130005126249
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H03839
[Journal Article] Stereocontrolled solid-phase synthesis of PO/PS chimeric oligodeoxyribonucleotides on an automated synthesizer using an oxazaphospholidine-phosphoramidite method2016
- Author(s)
  Nukaga, Y.; Oka, N.; Wada, T.
- Journal Title
  
  J. Org. Chem.
  
  Volume: 81 Issue: 7 Pages: 2753-2762
- DOI
  10.1021/acs.joc.5b02793
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26410175, KAKENHI-PUBLICLY-26105720, KAKENHI-PROJECT-15H03839
[Journal Article] Chimeric Antisense Oligonucleotide Conjugated to α- Tocopherol2015
- Author(s)
  Nishina T, Numata J, Nishina K, Yoshida-Tanaka K, Nitta K, Piao W, Iwata R, Ito S, Kuwahara H, Wada T, Mizusawa H, Yokota T
- Journal Title
  
  Mol Ther Nucleic Acids
  
  Volume: 4 Pages: e220-e220
- DOI
  10.1038/mtna.2014.72
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26282136, KAKENHI-PROJECT-15H03839
[Journal Article] Enhancement of affinity of 2'-O-Me-oligonucleotides for complementary RNA by incorporating a stereoregulated boranophosphate backbone2015
- Author(s)
  Nukaga, Y.; Takemura, T.; Iwamoto, N.; Oka, N.; Wada, T.
- Journal Title
  
  RSC Adv.
  
  Volume: 5 Issue: 4 Pages: 2392-2395
- DOI
  10.1039/c4ra11335g
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26410175, KAKENHI-PUBLICLY-26105720, KAKENHI-PROJECT-15H03839
[Journal Article] Synthesis and properties of vitamin E analog-conjugated neomycin for delivery of RNAi drugs to liver cells2015
- Author(s)
  Iwata R, Nakayama F, Hirochi S, Sato K, Piao W, Nishina K, Yokota T, Wada T
- Journal Title
  
  Bioorg Med Chem. Lett
  
  Volume: 25 Issue: 4 Pages: 815-819
- DOI
  10.1016/j.bmcl.2014.12.079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26282136, KAKENHI-PROJECT-15H03839
[Journal Article] Synthesis and properties of double-stranded RNA-bindable oligodiaminogalactose derivatives conjugated with vitamin E2014
- Author(s)
  Rintaro Iwata, Kazutaka Nishina, Takanori Yokota, Takeshi Wada
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 Issue: 4 Pages: 1394-1403
- DOI
  10.1016/j.bmc.2013.12.060
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-26282136
[Journal Article] 3-Nitro-l,2,4-triazol-l-yl-tris(pyrrolidin-1-yl)phosphonium hexafluorophosphate (PyNTP) as a condensing reagent for solid-phase peptide synthesis2014
- Author(s)
  Keita Saito, Takeshi Wada
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 55 Issue: 12 Pages: 1991-1993
- DOI
  10.1016/j.tetlet.2014.02.013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Synthesis and properties of double-stranded RNA-bindable oligodiaminogalactose derivatives conju-gated with vitamin E2014
- Author(s)
  Iwata R, Nishina K, Yokota, T, Wada T
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22(4) Pages: 1394-1403
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Solid-phase Synthesis of P-Boronated Oligonucleotides by the H-Boranophosphonate Method2014
- Author(s)
  Sho Uehara, Shingo Hiura, Renpei Higashida, Natsuhisa Oka, Takeshi Wada
- Journal Title
  
  J. Org. Chem.
  
  Volume: 79 Issue: 8 Pages: 3465-3472
- DOI
  10.1021/jo500185b
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008, KAKENHI-PUBLICLY-24105510, KAKENHI-PROJECT-24790108
[Journal Article] Solid-phase synthesis of p-boronated oligonucleotides by the H-boranophosphonate method2014
- Author(s)
  Uehara S, Hiura S, Higashida R, Oka N, Wada T
- Journal Title
  
  J. Org. Chem.
  
  Volume: 79(8) Pages: 3465-72
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled synthesis of dinucleoside phosphorothioates using a fluorous tag2013
- Author(s)
  Oka N, Murakami R, Kondo T, Wada T
- Journal Title
  
  J. Fluor. Chem.
  
  Volume: 150 Pages: 85-91
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereoselective synthesis of P-modified α-glycosyl phosphates by the oxazaphospholidine approach2013
- Author(s)
  Noro M, Fujita S, Wada T
- Journal Title
  
  Org. Lett.
  
  Volume: 15(23) Pages: 5948-51
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereoselective Synthesis of P-Modified α-Glycosyl Phosphates by the Oxazaphospholidine Approach2013
- Author(s)
  Mihoko Noro, Shoichi Fujita, Takeshi Wada
- Journal Title
  
  Org. Lett.
  
  Volume: 15 Issue: 23 Pages: 5948-5951
- DOI
  10.1021/ol402785h
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Synthesis and properties of cationic oligopeptides with different side chain lengths that bind to RNA duplexes2013
- Author(s)
  Maeda Y, Iwata R, Wada T
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 21(7) Pages: 1717-23
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Glycosylation of alcohols using glycosyl boranophosphates as glycosyl donors2013
- Author(s)
  Natsuhisa Oka, Shiro Tatsumi, Fumiko Matsumura, Takeshi Wada
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 54 Issue: 29 Pages: 3731-3734
- DOI
  10.1016/j.tetlet.2013.04.032
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008, KAKENHI-PUBLICLY-24105510, KAKENHI-PROJECT-24790108
[Journal Article] A protein-protein interaction assay based on the functional complementa tion of mutant firefly luciferase.2013
- Author(s)
  Yuki Ohmuro-Matsuyama, Kota Nakano, Aoi Kimura, Keiichi Ayabe and Hiroshi Ueda
- Journal Title
  
  Analytieal Chemistry
  
  Volume: 85 Issue: 16 Pages: 7935-7940
- DOI
  10.1021/ac4016825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J40072, KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-24360336
[Journal Article] リン原子修飾核酸の合成と医薬への応用2012
- Author(s)
  和田猛
- Journal Title
  
  医薬ジャーナル
  
  Volume: 48 Pages: 71-76
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled Solid- Phase Synthesis of Phosphorothioate Oligoribonucleotides Using 2'-O-(2- Cyanoethoxymethyl)-Nucleoside 3'-O- Oxazaphospholi- dine Monomers2012
- Author(s)
  Nukaga, Y., Yamada, K., Ogata, T., Oka, N., Wada, T.
- Journal Title
  
  J. Org. Chem.
  
  Volume: 77 Pages: 7913-7922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Stereo-controlled synthesis of oligodeoxyribonucleoside boranophosphates by an oxazaphospholidine approach using acid-labile N-protecting groups2012
- Author(s)
  Iwamoto N, Oka N, Wada T
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 53(33) Pages: 4361-4364
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Synthesis of nucleoside 5'-boranophosphorothioate derivatives using an H-boranophosphonate monoester as a precursor2012
- Author(s)
  Oka N, Takayama Y, Ando K, Wada T
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22(14) Pages: 4571-4
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled solid-phase synthesis of phosphorothioate oligoribonucleotides using 2'-O-(2-cyanoethoxymethyl)-nucleoside 3'-O-oxazaphospholidine monomers2012
- Author(s)
  Nukaga Y, Yamada K, Ogata T, Oka N, Wada T
- Journal Title
  
  J. Org. Chem.
  
  Volume: 77(18) Pages: 7913-22
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] 核酸医薬品に求められるもの2012
- Author(s)
  和田猛
- Journal Title
  
  医薬ジャーナル
  
  Volume: 48 Pages: 61-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] 核酸医薬品に求められるもの2012
- Author(s)
  和田猛
- Journal Title
  
  医薬ジャーナル
  
  Volume: 48 Pages: 61-63
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] リン原子修飾核酸の合成と医薬への応用2012
- Author(s)
  和田猛
- Journal Title
  
  医薬ジャーナル
  
  Volume: 48 Pages: 71-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Synthesis and properties of novel 2'-O-alkoxymethyl-modified nucleic acids2011
- Author(s)
  Arai, K., Uchiyama, N., Wada, T.
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume: 21 Issue: 21 Pages: 6285-6287
- DOI
  10.1016/j.bmcl.2011.09.003
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-21350088
[Journal Article] Synthesis and properties of novel 2'-O-alkoxymethylmodified nucleic acids2011
- Author(s)
  Arai K, Uchiyama N, Wada T
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 21(21) Pages: 6285-7
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled synthesis of oligonucleotide analogs containing chiral in ternucleotidic phosphorus atoms2011
- Author(s)
  Oka, N., Wada, T.
- Journal Title
  
  Chem.Soc.Rev.
  
  Volume: 40 Issue: 12 Pages: 5829-5843
- DOI
  10.1039/c1cs15102a
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-21350088
[Journal Article] Synthesis of Oligodiaminosaccharides Having α-Glycoside Bonds and Their Interactions with Oligonucleotide Duplexes2011
- Author(s)
  Rintaro Iwata, Masafumi Sudo, Kenta Nagafuji, Takeshi Wada
- Journal Title
  
  Journal of the Organic Chemistry
  
  Volume: 76 Issue: 15 Pages: 5895-5906
- DOI
  10.1021/jo200951p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J05612, KAKENHI-PLANNED-21115008, KAKENHI-PROJECT-21350088
[Journal Article] Stereocontrolled synthesis of oligonucleotide analogs containing chiral internucleotidic phosphorus atoms2011
- Author(s)
  Oka N, Wada T
- Journal Title
  
  Chem. Soc. Rev.
  
  Volume: 40(12) Pages: 5829-43
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled synthesis of oligonucleotide analogs containing chiral internucleotidic phosphorus atoms2011
- Author(s)
  Oka, N., Wada, T.
- Journal Title
  
  Chem. Soc. Rev.
  
  Volume: 40 Pages: 5829-5843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea2010
- Author(s)
  Ikeuchi Y, Kimura S, Numata T, Nakamura D, Yokogawa T, Ogata T, Wada T, Suzuki T, Suzuki T
- Journal Title
  
  Nat Chem Biol
  
  Volume: 6(4) Pages: 277-282
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21115001
[Journal Article] Solid-phase synthesis of oligodeoxyribonucleotides without base protection utilizing O-selective reaction of oxazaphospholidine derivatives2010
- Author(s)
  Oka, N., Maizuru, Y., Shimizu, M., Wada, T.
- Journal Title
  
  Nucleos.Nucleot.Nucl.Acids
  
  Volume: 29 Pages: 144-154
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Solid-phase synthesis of oligodeoxyribonucleotides without base protection utilizing O-selective reaction of oxazaphospholidine derivatives2010
- Author(s)
  Oka N, Maizuru Y, Shimizu M, Wada T
- Journal Title
  
  Nucleos Nucleot Nucl Acids.
  
  Volume: 29 Pages: 144-145
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea2010
- Author(s)
  Ikeuchi, Y., Kimura, S., Numata, T., Nakamura, D., Yokogawa, T., Ogata T., Wada, T., Suzuki, T., Suzuki, T.
- Journal Title
  
  Nat.Chem.Biol.
  
  Volume: 6 Pages: 277-282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Synthesis and biological activity of artificial mRNA prepared with novel phosphorylating reagents2010
- Author(s)
  Nagata, S., Hamasaki, T., Uetake, K Masuda, H., Takagaki, K., Oka, N Wada.T., Ohgi, T., Yano, J.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 38 Pages: 7845-7857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Synthesis, gene-silencing activity and nuclease resistance of 3'-3'-linked double short hairpin RNA2010
- Author(s)
  Masuda, H., Watanabe, N., Naruoka, H., Nagata, S., Takagaki K., Wada, T., Yano J.
- Journal Title
  
  Bioorg Med.Chem.
  
  Volume: 18 Pages: 8277-8283
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Synthesis and biological activity of artificial mRNA prepared with novel phosphorylating reagents2010
- Author(s)
  Nagata, S., Hamasaki, T., Uetake, K., Masuda, H., Takagaki, K., Oka, N., Wada, T., Ohgi, T., Yano, J.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 38 Pages: 7845-7857
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Solid-phase synthesis of oligodeoxyribonucleotides without base protection utilizing O-selective reaction of oxazaphospholidine derivatives2010
- Author(s)
  Oka, N., Maizuru, Y., Shimizu, M., Wada, T.
- Journal Title
  
  Nucleos.Nucleot.Nucl.Acids
  
  Volume: 29 Pages: 144-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Rapid glycosylation under extremely mild acidic conditions.Use of ammonium salts to activate glycosyl phosphites via P-protonation2010
- Author(s)
  Matsumura, F., Tatsumi, S., Oka, N., Wada, T.
- Journal Title
  
  Carbohyd.Res.
  
  Volume: 345 Pages: 1211-1215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] 1,2-trans-selective synthesis of Glycosyl Boranophosphates and their utility as building blocks for the synthesis of phosphodiester-linked disaccharides2010
- Author(s)
  Sato, K., Oka, N., Fujita, S., Matsu mura, F., Wada, T.
- Journal Title
  
  J.Org.Chem.
  
  Volume: 75 Pages: 2147-2156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Synthesis, gene-silencing activity and nuclease resistance of 3'-3'-linked double short hairpin RNA2010
- Author(s)
  Masuda, H., Watanabe, N., Naruoka, H., Nagata, S., Takagaki K., Wada, T., Yano J.
- Journal Title
  
  Bioorg Med.Chem.
  
  Volume: 18 Pages: 8277-8283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea2010
- Author(s)
  Ikeuchi, Y., Kimura, S., Numata, T., Nakamura, D., Yokogawa, T., Ogata, T., Wada, T., Suzuki, T., Suzuki, T.
- Journal Title
  
  Nat.Chem.Biol.
  
  Volume: 6 Pages: 277-282
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled Solid-phase Synthesis of Oligonucleoside H-phosphonates by an Oxazaphospholidine Approach2009
- Author(s)
  Iwamoto, N., Oka, N., Sato, T., Wada, T.
- Journal Title
  
  Angew.Chem.Int.Ed. 48
  
  Pages: 496-499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Stereo-controlled synthesis of oligodeoxyribonucleoside boranophosphates via stereodefined H-phosphonate intermediates2009
- Author(s)
  Iwamoto N, Oka N, Wada T
- Journal Title
  
  Nucleic Acids Symp Ser.
  
  Volume: (53) Pages: 9-10
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled Synthesis of Oligoribonucleoside Phosphorothioates by an Oxazaphospholidine Approach2009
- Author(s)
  Oka, N., Kondo, T., Fujiwara, S., Maizuru, Y., Wada, T.
- Journal Title
  
  Org.Lett. 11
  
  Pages: 967-970
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Chemical synthesis of nucleoside H-boranophosphonates and their application as precursors of P-modified nucleotide analogues2009
- Author(s)
  Oka N, Higashida R, Takayama Y, Ando K, Wada T
- Journal Title
  
  Nucleic Acids Symp Ser.
  
  Volume: (53) Pages: 111-2
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Stereocontrolled synthesis of oligodeoxyribonucleoside boranophosphates via stereodefined H-phosphonate intermediate2009
- Author(s)
  Iwamoto, N., Oka, N., Wada, T.
- Journal Title
  
  Nucleic Acids Symp. Ser. 53
  
  Pages: 9-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Nucleoside H-Boranophosphonates : a New Class of Boron-Containing Nucleotide Analogues2009
- Author(s)
  Higashida, R., Oka, N., Kawanaka, T., Wada, T.
- Journal Title
  
  Chem.Commun.
  
  Pages: 2466-2468
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Chemical synthesis of nucleoside H-boranophopsphonates and their application as precursors of P-modified nucleotide analogue2009
- Author(s)
  Oka, N., Higashida, R., Takayama, Y., Ando, K., Wada, T.
- Journal Title
  
  Nucleic Acids Symp.Ser. 53
  
  Pages: 111-112
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21115008
[Journal Article] Chemical Synthesis and Properties of 5-Taurinomethyluridine and 5-Taurinomethyl-2-thiouridine2009
- Author(s)
  Ogata, T., Shimazaki, T., Umemoto, T., Kurata, S., Ohtsuki, T., Suzuki, T., Wada, T.
- Journal Title
  
  J.Org. Chem. 74
  
  Pages: 2585-2588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350088
[Journal Article] Synthesis of glycosyl boranophosphates and their applications as precursors of glycosyl phosphate analogues2008
- Author(s)
  Matsumura, F.; Oka, N; Wada, T.
- Journal Title
  
  Organic Letters 10
  
  Pages: 1557-1560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Solid-phase synthesis of backbone-modefied DNA analogs by the boranophosphotriester method using new protecting groups for nucleobases2008
- Author(s)
  Kawanaka, T., Shimizu, M., Shintani, N, Wada, T.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 13
  
  Pages: 783-3786
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Synthesis of Dinucleoside Phosphates and their Analogs by the Boranophosphotriester Method Using Azido-Based Protecting Groups2007
- Author(s)
  Kawanaka, T., Shintani, N., Shimizu, M, Wada, T.
- Journal Title
  
  Tetrahedron Lett. 48
  
  Pages: 1973-1976
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Chemical synthesis and properties of stereoregulated phosphorothioate RNAs2007
- Author(s)
  Wada. T., Kondo, T., Fujiwara, S., Sato, T., Oka, N.
- Journal Title
  
  □Nucleic Acids Symp. Ser. 51
  
  Pages: 119-120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Nucleoside H-boranophosphonates:Synthesis and properties of a new class of nucleotide analogs2007
- Author(s)
  Higashida, R.; Kawanaka, T.; Oka, N.; Wada, T.
- Journal Title
  
  Nucleic Acids Symp.Ser 51
  
  Pages: 133-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Solid-phase synthesis and propenies of chiral peptide nucleic acids bearing cationic side chains2007
- Author(s)
  Harada, H.; Funayama, S., Shoji, Y; Wada, T.
- Journal Title
  
  Nueleic Acids Symp.Ser 51
  
  Pages: 259-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase2007
- Author(s)
  Watanabe, K., Toh, Y., Suto, K., Shimizu, Y., Oka, N., Wada. T., Tomita, K.
- Journal Title
  
  Nature 449
  
  Pages: 867-871
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Protein-based peptide-bond formation by aminoacyl-tRNA protein transfcrase2007
- Author(s)
  Watanabe, K.; Toh, Y.; Suto, K.; Shimizu, Y.; Oka, N.; Wada, T.; Tomita, K.
- Journal Title
  
  Nature 449
  
  Pages: 867-871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Solid-phase synthesis and properties of chiral peptide nucleic acids bearing cationic side chains2007
- Author(s)
  Harada, H., Funayama, S., Shoji, Y, Wada. T.
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages: 259-260
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Synthesis of dinucleoside phosphates and their analogs by the boranophosphotriester method using azido-based protecting groups2007
- Author(s)
  Kawanaka, T.; Shintani, N.; Shimizu, M.; Wada, T.
- Journal Title
  
  Tetrahedron Letters 48
  
  Pages: 1973-1976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Nucleoside H-boranophosphonates : Synthesis and properties of a new class of nucleotide analogs2007
- Author(s)
  Higashida, R., Kawanaka, T., Oka, N., Wada. T.
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages: 133-134
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Chemical synthesis and properties of stereoregulated phosphorothioate RNAs2007
- Author(s)
  Wada, T.; Kondo, T.; Fujiwara, S.; Sato, T.; Oka, N.
- Journal Title
  
  Nucleic Acids Symp.Ser 51
  
  Pages: 119-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] 1,3-Dimethyl-2-(3-nitoro-1, 2, 4-triazol-1-yl)-2-pyrrolidin-1-yl-1, 3, 2-diazaphospholidinium Hexafluorophosphate : a Powerful Condensing Reagent for Phosphate and Phosphonate Esters2006
- Author(s)
  Oka, N., Shimizu, M., Saigo, K., Wada, T.
- Journal Title
  
  Tetrahedron 62
  
  Pages: 3667-3673
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Highly Chemo- and Regioselective Phosphitylation of Unprotected 2'-Deoxyribonucleosides2006
- Author(s)
  Kato, Y., Oka, N., Wada, T.
- Journal Title
  
  Tetrahedron Lett. 47
  
  Pages: 2501-2505
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] A Novel Linker for Solid-phase Synthesis Cleavable under Neutral Conditions2006
- Author(s)
  Murata, A., Wada, T.
- Journal Title
  
  Tetrahedron Lett. 47
  
  Pages: 2147-2150
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Synthesis of a Novel Ester Analog of Nucleic Acids Bearing a Serine Backbone2006
- Author(s)
  Murata, A., Wada, T.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 16
  
  Pages: 2933-2936
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Stereoselective Synthesis of Dinucleoside Boranophosphates by an Oxazaphospholidine Method2006
- Author(s)
  Wada, T., Maizuru, Y., Oka, N., Saigo, K.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 16
  
  Pages: 3111-3114
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Solid-phase Synthesis of Oligodeoxyribonucleoside Boranophosphates by the Boranophosphotriester Method2006
- Author(s)
  Shimizu, M., Saigo, K., Wada, T.
- Journal Title
  
  J. Org. Chem. 71
  
  Pages: 4262-4269
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Nitromethane as a Scavenger of Acrylonitrile in the Deprotection of Synthetic Oligonucleotides2005
- Author(s)
  Umemoto, T., Wada, T.
- Journal Title
  
  Tetrahedron Lett. 46
  
  Pages: 4251-4253
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Stereocontrolled Synthesis of Dinucleoside Boranophosphates by an Oxazaphospholidine Method2005
- Author(s)
  Oka, N., Maizuru, Y., Shimizu, M., Saigo, K., Wada, T.
- Journal Title
  
  Nucleic Acids Symp.Ser. 49
  
  Pages: 131-132
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Highly Chemo- and Regioselective Phosphitylation of Unprotected 2'-Deoxyribonucleosides2005
- Author(s)
  Kato, Y., Oka, N., Wada, T.
- Journal Title
  
  Tetrahedron Lett. 47(in press)
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Stereocontrolled Synthesis of Phosphorothioate DNA by the Oxazaphospholidine Approach2005
- Author(s)
  Wada, T.
- Journal Title
  
  Front.Org.Chem. 1・1
  
  Pages: 41-61
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Stereocontrolled Synthesis of Phosphorothioate DNA by the Oxazaphospholidine Approach2005
- Author(s)
  Wada, T.
- Journal Title
  
  Front Org.Chem. 1・1
  
  Pages: 41-61
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] A Novel Method for the Synthesis of DNA Using 2'-Deoxyribonucleoside 5'-Phosphites as Monomer Units2005
- Author(s)
  Kato, Y., Saigo, K., Wada, T.
- Journal Title
  
  Nucleic Acids Symp.Ser. 49
  
  Pages: 129-130
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Stereocontrolled synthesis of phosphorothioate DNA by the oxazaphospholidine approach.2005
- Author(s)
  Wada, T.
- Journal Title
  
  Front. Org. Chem. 1
  
  Pages: 41-61
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] A Novel Method for the Synthesis of DNA and its Analogs by the Use of BH_3 as protecting Group for Phosphonic Acid2005
- Author(s)
  Kawanaka, T., Shimizu, M., Saigo, K., Wada, T.
- Journal Title
  
  Nucleic Acids Symp.Ser. 49
  
  Pages: 27-28
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Oligoribonucleotide Synthesis by the Use of 1-(2-Cyanoethoxy)ethyl (CEE) As a 2'-Hydroxy Protecting Group2004
- Author(s)
  Umemoto, t., Wada, T.
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 9529-9531
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] RNA Interference (RNAi) and Chemical Synthesis of RNA2004
- Author(s)
  Wada, T.
- Journal Title
  
  Bio Industry 21
  
  Pages: 17-24
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Stereocontrolled Synthesis of Phosphorothioate RNA by the Oxazaphospholidine Approach2004
- Author(s)
  Wada, T., Fujiwara, S., Sato, T., Oka, N., Saigo, K.
- Journal Title
  
  Nucleic Acids Symp.Ser. 47
  
  Pages: 57-58
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] A Novel Method for the Synthesis of Dinucleoside Boranophosphates by a Boranophosohotriester Method2004
- Author(s)
  Shimizu, M., Wada, T., Oka, N., Saigo, K.
- Journal Title
  
  J.Org.Chem. 69・16
  
  Pages: 5261-5268
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Stereocontrolled Synthesis of Phosphorothioate RNA by the Oxazaphospholi-dine Approach2004
- Author(s)
  Wada.T., Fujiwara, S., Sato, T., Oka, N., Saigo, K.
- Journal Title
  
  Nucleic Acids Symp.Ser. 47
  
  Pages: 57-58
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] RNA Interference (RNAi) and Chemical Synthesis of RNA2004
- Author(s)
  Wada, T.
- Journal Title
  
  Bio Industry 21
  
  Pages: 17-24
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] BH_3 as a Protecting Group for Phosphonic Acids : A Novel Method for the Synthesis of Dinucleoside H-Phosphonates2004
- Author(s)
  Shimizu, M., Tamura, K., Wada, T., Saigo, K.
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 371-374
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] A Novel Method for the Synthesis of Dinucleoside Boranophosphates by a Boranophosohotriester Method2004
- Author(s)
  Shimizu, M., Wada, T., Oka, N., Saigo, K.
- Journal Title
  
  J.Org.Chem. 69・16
  
  Pages: 5261-5268
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] BH_3 as a Protecting Group for Phosphonic Acids : A Novel Method for the Synthesis of Dinucleoside H-Phosphonates2004
- Author(s)
  Shimizu, M., Tamura, K., Wada, T., Saigo, K.
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 371-374
- Data Source
  KAKENHI-PROJECT-16350085
[Journal Article] Oligoribonucleotide Synthesis by the Use of 1-(2-Cyanoethoxy)ethyl (CEE) As a 2'-Hydroxy Protecting Group2004
- Author(s)
  Umemoto, T., Wada, T.
- Journal Title
  
  Tetrahedron Lett. 45
  
  Pages: 9529-9531
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Solid-phase Synthesis of a Novel Polyester analog of Nucleic Acid Bearing Serine Backbone2003
- Author(s)
  Wada, T., Murata, A., Tsuneyama, T., Saigo, K.
- Journal Title
  
  Peptide Science 40
  
  Pages: 159-160
- NAID
  10012654047
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Solid-phase Synthesis of a Novel Polyester Analog of Nucleic Acid Bearing Serine Backbone2003
- Author(s)
  Wada, T. et al.
- Journal Title
  
  Peptide Science 40
  
  Pages: 159-150
- NAID
  10012654047
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Solid-phase Synthesis of a Novel Polyester Analog of Nucleic Acid Bearing Serine Backbone2003
- Author(s)
  Wada, T., Murata, A., Tsuneyama, T., Saigo, K.
- Journal Title
  
  Peptide Science 40
  
  Pages: 159-150
- NAID
  10012654047
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Diastereocontrolled Synthesis of Phosphorothioate DNA via an Oxazaphospholidine Approach Using a Novel Class of Activators, Dialkyl(cyanomethyl)-ammonium salts2003
- Author(s)
  Oka, N, Wada, T., Saigo, K.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1411-1413
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Synthesis of Chiral Oligopeptides which Recognize Double-stranded DNAs2003
- Author(s)
  Wada, T., Funayama, S., Shoji, Y., Saigo, K.
- Journal Title
  
  Peptids Science 40
  
  Pages: 181-182
- NAID
  10017676147
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Synthesis of Dinucleoside Boranophosphates by a Boranophosphotriester Approach2003
- Author(s)
  Wada, T., et al.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1431-1433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] An Oxazaphospholidine Approach for the Stereocontrolled Synthesis of Oligonucleoside Phosphorothioates2003
- Author(s)
  Oka, N, Wada.T., Saigo, K.
- Journal Title
  
  J.Am.Chem.Soc. 125
  
  Pages: 8307-8317
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Synthesis of Chiral Oligopeptides which Recognize Double-stranded DNAs2003
- Author(s)
  Wada, T. et al.
- Journal Title
  
  Peptide Science 40
  
  Pages: 181-182
- NAID
  10017676147
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Reaction Mechanism for the Sterercontrolled Synthesis of Phosphorothioate DNA by the Oxazaphospholidine Approach2003
- Author(s)
  Wada.T., Oka, N, Saigo, K.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1471-1473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Reaction Mechanism for the Sterercontrolled Synthesis of Phosphorothioate DNA by the Oxazaphospholidine Approach2003
- Author(s)
  Wada, T., Oka, N, Saigo, K.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1431-1433
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Diastereocontrolled Synthesis of Phosphorothioate DNA via an Oxazaphospholidine Approach Using a Novel Class of Activators, Dialkyl(cyanomethyl)ammonium salts2003
- Author(s)
  Oka, N, Wada, T., Saigo, K.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1141-1143
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Reaction Mechanism for the Sterercontrolled Synthesis of Phosphorothio- ate DNA by the Oxazaphospholidine Approach2003
- Author(s)
  Wada, T. et al.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 222
  
  Pages: 1471-1473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] Synthesis of Chiral Oligopeptides which Recognize Double-stranded DNAs2003
- Author(s)
  Wada.T., Funayama, S., Shoji, Y., Saigo, K.
- Journal Title
  
  Peptide Science 40
  
  Pages: 181-182
- NAID
  10017676147
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Synthesis of Dinucleoside Boranophosphates by a Boranophosphotriester Approach2003
- Author(s)
  Wada.T., Shimizu, M., Oka, N., Saigo, K.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1431-1433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Synthesis of Dinucleoside Boranophosphates by a Boranophosphotriester2003
- Author(s)
  Wada, T., Shimizu, M., Oka, N., Saigo, K.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids 22
  
  Pages: 1471-1473
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] An Oxazaphospholidine Approach for the Stereocontrolled Synthesis of Ologonucleoside Phosphorothioates2003
- Author(s)
  Oka, N., Wada, T., Saigo, K.
- Journal Title
  
  J. Am. Chem. Soc. 125
  
  Pages: 8307-8317
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Taurine as a Constituent of Mitochondrial tRNAs : New Insight into the Functions of Taurine and Human Mitochondrial Diseases2002
- Author(s)
  Suzuki, T., Suzuki, T., Wada.T., Saigo, K., Watanabe, K.
- Journal Title
  
  EMBO J. 21
  
  Pages: 6581-6589
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] Diastereocontrolled Synthesis of Dinucleoside Phosphorothioates Using a Novel Activators, Dialkyl(cyanomethyl)ammonium Tetrafluoroborates2002
- Author(s)
  Oka, N, Wada.T., Saigo, K.
- Journal Title
  
  J.Am.Chem.Soc. 124
  
  Pages: 1962-1963
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] A New Boranophosphorylation Reaction for the Synthesis of Deoxyribonucleoside Boranophosphates2002
- Author(s)
  Wada.T., Shimizu, M., Oka, N., Saigo, K.
- Journal Title
  
  Tetrahedron Lett. 43
  
  Pages: 4137-4140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580607
[Journal Article] A New Boranophosphorylation Reaction for the Synthesis of Deoxyribo- nucleoside Boranophosphates2002
- Author(s)
  Wada, T. et al.
- Journal Title
  
  Tetrahedron Lett. 43
  
  Pages: 4137-4140
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Journal Article] A New Boranophosphorylation Reaction for the Synthesis of Deoxyribonucleoside Boranophosphates2002
- Author(s)
  Wada, T.et al.
- Journal Title
  
  Tetrahedron Lett. 43
  
  Pages: 4137-4140
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Patent] Ｈ－ホスホネート法を用いたモルフォリノ核酸の製造方法2022
- Inventor(s)
  和田猛、鶴﨑大樹、佐藤一樹、高橋大輔、鳥居高好
- Industrial Property Rights Holder
  和田猛、鶴﨑大樹、佐藤一樹、高橋大輔、鳥居高好
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-23K21353
[Patent] ホスホロチオエート及びボラノホスフェートを含むキメラ型核酸オリゴマー、及びその製造方法2022
- Inventor(s)
  和田猛、高橋裕平、佐藤一樹
- Industrial Property Rights Holder
  和田猛、高橋裕平、佐藤一樹
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-23K21353
[Patent] ホスホロチオエート及びボラノホスフェートを含むキメラ型核酸オリゴマー、及びその製造方法2021
- Inventor(s)
  5.和田猛、佐藤一樹、髙橋裕平
- Industrial Property Rights Holder
  5.和田猛、佐藤一樹、髙橋裕平
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-092873
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-23K21353
[Patent] 核酸医薬副作用軽減剤、該核酸医薬副作用軽減剤を含む医薬組成物、並びに核酸医薬の副作用惹起性を軽減する方法2019
- Inventor(s)
  4.和田猛、佐藤一樹
- Industrial Property Rights Holder
  4.和田猛、佐藤一樹
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17K08933
[Patent] リン原子の立体化学が制御されたヘテロ二本鎖核酸医薬2019
- Inventor(s)
  和田猛、横田隆徳、清水護
- Industrial Property Rights Holder
  和田猛、横田隆徳、清水護
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-057175
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-15H03839
[Patent] カチオン性人工オリゴ糖による二重鎖ＲＮＡの安定化2018
- Inventor(s)
  和田猛、原倫太朗、佐藤一樹、芝崎太、入江敦
- Industrial Property Rights Holder
  和田猛、原倫太朗、佐藤一樹、芝崎太、入江敦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-204172
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-15H03839
[Patent] RNAハイブリッド形成用核酸オリゴマー2016
- Inventor(s)
  和田猛、吉野怜次郎、岩田倫太朗
- Industrial Property Rights Holder
  和田猛、吉野怜次郎、岩田倫太朗
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-046181
- Filing Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15H03839
[Patent] 重合性化合物、化合物、及び、ボラノホスフェートオリゴマーの製造方法2016
- Inventor(s)
  和田猛、齋藤竜也、石井友香、額賀陽平
- Industrial Property Rights Holder
  和田猛、齋藤竜也、石井友香、額賀陽平
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-221656
- Filing Date
  2016-11-14
- Data Source
  KAKENHI-PROJECT-15H03839
[Patent] 二重鎖核酸結合剤、当該結合剤－二重鎖核酸複合体、当該複合体を含有する医薬品組成物、及び、当該複合体の製造方法2014
- Inventor(s)
  和田猛、前田雄介、横田隆徳、仁科一隆
- Industrial Property Rights Holder
  和田猛、前田雄介、横田隆徳、仁科一隆
- Industrial Property Rights Type
  特許
- Filing Date
  2014-03-20
- Overseas
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 二重鎖核酸結合剤、当該結合剤二重鎖核酸複合体、当該複合体を含有する医薬品組成物、及び、当該複合体の製造方法2014
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Filing Date
  2014-03-20
- Overseas
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] ボラノホスフェート化合物、及び核酸オリゴマー2013
- Inventor(s)
  和田猛、植原渉
- Industrial Property Rights Holder
  和田猛、植原渉
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-234384
- Filing Date
  2013-11-12
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] ボラノホスフェート化合物、及び核酸オリゴマー2013
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Industrial Property Number
  2013-234384
- Filing Date
  2013-11-12
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 二重鎖核酸結合剤、当該結合剤二重鎖核酸複合体、当該複合体を含有する医薬品組成物、及び、当該複合体の製造方法2013
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Industrial Property Number
  2013-057521
- Filing Date
  2013-03-21
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] β-Hairpin Peptides Which Bind to Nucleic Acid Duplexes2013
- Inventor(s)
  和田猛、前田雄介、横田隆徳、仁科一隆
- Industrial Property Rights Holder
  和田猛、前田雄介、横田隆徳、仁科一隆
- Industrial Property Rights Type
  特許
- Filing Date
  2013-10-08
- Overseas
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 二重鎖核酸結合剤、当該結合剤－二重鎖核酸複合体、当該複合体を含有する医薬品組成物、及び、当該複合体の製造方法2013
- Inventor(s)
  横田隆徳、仁科一隆、和田猛、前田雄介
- Industrial Property Rights Holder
  横田隆徳、仁科一隆、和田猛、前田雄介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-057521
- Filing Date
  2013-03-21
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] β-Hairpin Peptides Which Bind to Nucleic Acid Duplexes2013
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Filing Date
  2013-10-08
- Overseas
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 中性条件下除去可能な2'-水酸基保護基を用いるRNAの製造法2012
- Inventor(s)
  和田猛、額賀陽平
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2012-02-19
- Overseas
- Data Source
  KAKENHI-PROJECT-21350088
[Patent] 中性条件下除去可能な2'-水酸基保護基を用いるRNAの製造法2012
- Inventor(s)
  和田猛、他
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2012-02-17
- Overseas
- Data Source
  KAKENHI-PROJECT-21350088
[Patent] 中性条件下除去可能な2'-水酸基保護基を用いるRNAの製造法2012
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Filing Date
  2012-02-19
- Overseas
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 中性条件下除去可能な2'-水酸基保護基を用いるRNAの製造法2012
- Inventor(s)
  和田猛、額賀陽平
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2012-02-19
- Overseas
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 糖1-リン酸誘導体の立体選択的製造方法2011
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Industrial Property Number
  2011-048824
- Filing Date
  2011-03-09
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 立体規則性の高いリボヌクレオチド類縁体及びデオキシリボヌクレオチド類縁体の製造法2011
- Inventor(s)
  和田猛、他
- Industrial Property Rights Holder
  株式会社キラルジェン
- Acquisition Date
  2011-10-25
- Data Source
  KAKENHI-PROJECT-21350088
[Patent] リボヌクレオシドホスホロチオエートの製造方法2011
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Filing Date
  2011-03-09
- Overseas
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 2'-O-修飾 RNA2011
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Filing Date
  2011-11-28
- Overseas
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] リボヌクレオシドホスホロチオエートの製造方法2011
- Inventor(s)
  和田猛、他
- Industrial Property Rights Holder
  株式会社キラルジェン
- Filing Date
  2011-03-09
- Data Source
  KAKENHI-PROJECT-21350088
[Patent] リボヌクレオシドホスホロチオエートの製造方法2011
- Inventor(s)
  和田猛、他
- Industrial Property Rights Holder
  株式会社キラルジェン
- Filing Date
  2011-03-09
- Overseas
- Data Source
  KAKENHI-PROJECT-21350088
[Patent] リボヌクレシドH-ボラノホスホネート2010
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Industrial Property Number
  2010-048823
- Filing Date
  2010-03-05
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 二重鎖RNA結合性オリゴアミノ糖2010
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Filing Date
  2010-03-09
- Overseas
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] リン酸化試薬2010
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Industrial Property Number
  2010-010260
- Filing Date
  2010-03-09
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 2'-O-修飾 RNA2010
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Filing Date
  2010-11-30
- Overseas
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 糖1-リン酸化合物の製造方法2010
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Industrial Property Number
  2010-050194
- Filing Date
  2010-03-08
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] リボヌクレオシドH-ボラノホスホネート2010
- Inventor(s)
  和田猛、日浦進吾
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2010-048823
- Filing Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-21350088
[Patent] 2'-O-修飾RNA2010
- Inventor(s)
  新井浩一郎清水護和田猛
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2010-11-30
- Overseas
- Data Source
  KAKENHI-PROJECT-21350088
[Patent] 2'-O-修飾RNA2010
- Inventor(s)
  和田猛、他
- Industrial Property Rights Holder
  東京大学・株式会社キラルジェン
- Filing Date
  2010-11-30
- Overseas
- Data Source
  KAKENHI-PROJECT-21350088
[Patent] リボヌクレオシドホスホロチオエートの製造方法2010
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Industrial Property Number
  2010-048824
- Filing Date
  2010-03-05
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 2'-O-修飾RNA2010
- Inventor(s)
  新井浩一郎, 清水護, 和田猛
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2010-11-30
- Overseas
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] リボヌクレオシドホスホロチオエートの製造方法2010
- Inventor(s)
  和田猛、額賀陽平
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2010-048824
- Filing Date
  2010-03-05
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] リボヌクレオシドホスホロチオエートの製造方法2010
- Inventor(s)
  和田猛、他
- Industrial Property Rights Holder
  株式会社キラルジェン
- Industrial Property Number
  2010-048824
- Filing Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-21350088
[Patent] オリゴアミノ糖化合物2010
- Inventor(s)
  和田猛, 他
- Industrial Property Rights Holder
  和田猛, 他
- Filing Date
  2010-03-09
- Overseas
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 立体規則性の高いジヌクレオシドホスホロチオエートの製造法2009
- Inventor(s)
  和田猛、岡夏央、西郷和彦
- Industrial Property Rights Holder
  (株)キラルジエン
- Industrial Property Number
  2006-511418
- Filing Date
  2009-07-03
- Data Source
  KAKENHI-PLANNED-21115008
[Patent] 5'-ホスフィチル化モノマーおよびH-ホスホネートオリゴヌクレオチド誘導体の製造方法2006
- Inventor(s)
  和田猛, 加藤有希子, 西郷和彦
- Industrial Property Rights Holder
  和田猛, 加藤有希子, 西郷和彦
- Industrial Property Number
  2005-513991
- Filing Date
  2006-01-20
- Data Source
  KAKENHI-PROJECT-16350085
[Patent] 立体規則性の高いリボヌクレオチド類縁体の製造法2004
- Inventor(s)
  和田猛, 西郷和彦, 岡夏央
- Industrial Property Rights Holder
  東京大学TLO
- Industrial Property Number
  2004-089152
- Filing Date
  2004-03-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Patent] ホラノホスフェートモノマーおよびそれを用いたオリゴヌクレオチドの製造法2004
- Inventor(s)
  和田猛, 西郷和彦, 清水護
- Industrial Property Rights Holder
  東京大学TLO
- Industrial Property Number
  2004-061617
- Filing Date
  2004-03-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13132203
[Presentation] リガンド結合型カチオン性ペプチドによるsiRNAのDDS技術2023
- Author(s)
  和田猛
- Organizer
  柏の葉ライフサイエンス協議会発足記念「交流の葉」コウリュウノハ
- Invited
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] 核酸医薬の安定化とデリバリーに有効な新規分子技術2022
- Author(s)
  和田猛
- Organizer
  大隅ライフサイエンス研究会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] 核酸医薬の有効性と安全性を向上させる新規分子技術2022
- Author(s)
  和田猛
- Organizer
  第28回日本遺伝子細胞治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] 核酸医薬の安定化・毒性軽減・デリバリーに有効な新規分子技術2022
- Author(s)
  和田猛
- Organizer
  第 38 回日本 DDS 学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] 核酸医薬の安定性・有効性・安全性を向上させるカチオン性人工分子の開発2022
- Author(s)
  和田猛
- Organizer
  データサイエンス医療研究部門・核酸創薬研究部門合同シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] 核酸医薬の有効性と安全性を向上させる新規分子技術2022
- Author(s)
  和田猛
- Organizer
  第9回筑波大学・東京理科大学合同リトリート
- Invited
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] A brief history of stereopure oligonucleotide therapeutics: chemical synthesis and applications2022
- Author(s)
  和田猛
- Organizer
  日本核酸医薬学会第7回年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] 核酸医薬の展望～新たな合成技術が拓く未来2021
- Author(s)
  和田猛
- Organizer
  CPhI Japan 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] Development of new molecular technologies for oligonucleotide therapeutics2021
- Author(s)
  Takeshi Wada
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] 革新的次世代医薬への期待2021
- Author(s)
  和田猛
- Organizer
  TUSフォーラム2021
- Invited
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] 核酸医薬の有効性と安全性を向上させる新規分子技術2021
- Author(s)
  和田猛
- Organizer
  第23回ケムステバーチャルシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] 究極の核酸合成反応を目指して2021
- Author(s)
  和田猛
- Organizer
  The 48th International Symposium on Nucleic Acids Chemistry 2021 (ISNAC2021)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] 日本発の新規モダリティを継続的に生み出すためには何が必要か？2021
- Author(s)
  和田猛
- Organizer
  BioJapan2021
- Invited
- Data Source
  KAKENHI-PROJECT-23K21353
[Presentation] 葉酸結合型カチオン性オリゴペプチドを用いた膵癌特異的なsiRNAのデリバリー2020
- Author(s)
  佐藤一樹、高木一憲、原倫太朗、谷内恵介、和田猛
- Organizer
  第69回高分子討論会
- Data Source
  KAKENHI-PROJECT-20K08359
[Presentation] Development of new molecular technologies for oligonucleotide therapeutics2019
- Author(s)
  Takeshi Wada
- Organizer
  Alnylam Pharmaceuticals inc.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] 核酸医薬への新しいアプローチ2019
- Author(s)
  和田猛
- Organizer
  “未来へのバイオ技術”勉強会「核酸医薬開発の動向と課題」
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] Stereocontrolled synthesis and properties of phosphorus modified nucleic acid drugs2019
- Author(s)
  Takeshi Wada
- Organizer
  The 27th French-Japanese Symposium on Medicinal and Fine Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] 画期的な新規核酸医薬の分子技術の創出　DNA/RNAヘテロ核酸2019
- Author(s)
  和田猛
- Organizer
  分子技術シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] アカデミック・ディテーリング：化学構造式からのアプローチ2019
- Author(s)
  和田猛
- Organizer
  第5回日本医薬品安全性学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] 核酸医薬への新しい有機合成化学的アプローチ2019
- Author(s)
  和田猛
- Organizer
  「ニューモダリティと有機合成化学」研究部会【第1回公開講演会】
- Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] 人工核酸で病気を治す！～核酸医薬という新しいお薬～2019
- Author(s)
  和田猛
- Organizer
  第9回CSJ化学フェスタ
- Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] Development of new molecular technologies for oligonucleotide therapeutics2019
- Author(s)
  Takeshi Wada
- Organizer
  Neuroscience R&D Summit 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] Functional control of nucleic acid drugs by artificial cationic molecules2019
- Author(s)
  Takeshi Wada
- Organizer
  Asian 3 Roundtable on Nucleic Acids (A3RONA 2019) Asian 3 Roundtable on Nucleic Acids
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] 大学発　創薬ベンチャーの挑戦2019
- Author(s)
  和田猛
- Organizer
  第２回 ISPACOSシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] リン原子の立体化学が制御された核酸医薬の開発2019
- Author(s)
  和田猛
- Organizer
  第５回中分子創薬に関わる次世代産業研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] リン原子の立体化学が制御されたPB/PS-キメラDNAの合成2019
- Author(s)
  半澤壮太、小暮智紀、斎藤竜也、額賀陽平、原倫太朗、佐藤一樹、和田猛
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬の安定化と高活性化を実現する分子技術2019
- Author(s)
  和田猛
- Organizer
  東京理科大学総合研究院核酸創薬部門第1回シンポジウム/研究交流会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] 核酸医薬の有効性と安全性を向上させる分子技術の開発2019
- Author(s)
  和田猛
- Organizer
  第415回CBI学会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] Development of new molecular technologies for oligonucleotide therapeutics2019
- Author(s)
  Takeshi Wada
- Organizer
  Commemorative International Symposium of the Japan Society of Nucleic Acids Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] 核酸医薬分子合成の基礎となるリンの化学2019
- Author(s)
  和田猛
- Organizer
  日本核酸医薬学会第5回年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] ボラノホスフェートDNAを出発物質としたリン原子修飾DNAの固相合成2019
- Author(s)
  浪岡優吉、五十嵐愛弓、原倫太朗、佐藤一樹、和田猛
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] Control of cleavage sites by RNase H using cationic oligopeptides2018
- Author(s)
  Taku Suenaga, Yuta Mitsuhashi, Yusuke Maeda, Rintaro Hara, Kazuki Sato, Takeshi Wada
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry 2018 (ISNAC2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] H-ボラノホスホネート法によるボラン修飾型RNAの固相合成2018
- Author(s)
  松田浩昌、伊藤弘暁、首藤智仁、植原渉、原倫太朗、和田猛
- Organizer
  日本核酸医薬学会第4回年会
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] Functional Control of Nucleic Acid Drugs Based on Strict Three-dimensional Structure Recognition2018
- Author(s)
  Takeshi Wada
- Organizer
  Asian 3 Roundtable on Nucleic Acids 2018 (A3RONA 2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] リン原子の立体化学を厳密に制御したリン原子修飾核酸医薬の開発2018
- Author(s)
  和田猛
- Organizer
  日本核酸医薬学会第4回年会
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 厳密な立体構造認識に基づく核酸医薬の機能制御2018
- Author(s)
  和田猛
- Organizer
  第34回創薬セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] Solid-phase synthesis of phosphate/boranophosphate (PO/PB) chimericoligodeoxyribonucleotides by the H-boranophosphonate-H-phosphonate method2018
- Author(s)
  Hiroki Imai, Tomohito Shuto, Rintaro Hara, Kazuki Sato, Takeshi Wada
- Organizer
  The 45th International Symposium on Nucleic Acids Chemistry 2018 (ISNAC2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 化学構造式から見たアカデミック・ディテーリング2018
- Author(s)
  和田猛
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] 本邦初アカデミック・ディテーリング教育プログラム開発-;基礎を臨床につなぐPBL チュートリアル-2018
- Author(s)
  小茂田　昌代, 和田　猛, 高橋　秀依, 嶋田　修治, 真野　泰成, 鈴木　立紀, 高澤　涼子, 尾関　理恵, 青山　隆夫
- Organizer
  第9回日本アプライド・セラピューティクス
- Invited
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] Functional control of nucleic acid drugs based on strict three-dimensional structure recongnition2018
- Author(s)
  Takeshi Wada
- Organizer
  FIBER International Summit for Nucleic Acids 2018 (FISNA2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬への有機合成化学的アプローチ2018
- Author(s)
  和田猛
- Organizer
  平成30年度後期（秋季）有機合成化学講習会
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬の安定化と高活性化に向けた新しい分子技術の開発2017
- Author(s)
  和田猛
- Organizer
  第17回　CBSM 2017
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬の安定化と高活性化を実現する分子技術2017
- Author(s)
  和田猛
- Organizer
  第36回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] RNAi医薬の安定化と活性化に向けた新分子技術の開発2017
- Author(s)
  和田猛
- Organizer
  2017年度生命科学系学会合同年次大会 ConBio2017（第40回分子生物学会年会、第90回日本生化学会大会）
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] リン原子修飾核酸の立体選択的合成と医薬への応用2017
- Author(s)
  和田猛
- Organizer
  第3回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬の安定化と高活性化へ向けた分子技術の開発2017
- Author(s)
  和田　猛
- Organizer
  BioJapan2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] 核酸医薬の安定化と高活性化へ向けた分子技術の開発2017
- Author(s)
  和田猛
- Organizer
  大塚有機合成シンポジウム2017
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬の安定化と高活性化へ向けた分子技術の開発2017
- Author(s)
  和田猛
- Organizer
  BioJapan2017
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬への有機化学的アプローチ2017
- Author(s)
  和田猛
- Organizer
  第2回 LiHubフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] Stereocontrolled synthesis and properties of boranophosphate DNA2017
- Author(s)
  和田猛
- Organizer
  FISNA2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] Stereocontrolled synthesis and properties of boranophosphate DNA2017
- Author(s)
  和田　猛
- Organizer
  FISNA2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08933
[Presentation] Artificial cationic oligopeptides that stabilize and activate nucleic acid therapeutics2017
- Author(s)
  和田猛
- Organizer
  International symposium for the drug-discovery of the pyrrole-imidazole polyamides as novel biomedicines
- Place of Presentation
  日本大学桜門会館（東京）
- Year and Date
  2017-02-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬の安定化と高活性化に向けた新規分子技術の開発2016
- Author(s)
  和田猛
- Organizer
  BioJapan 2016
- Place of Presentation
  パシフィコ横浜（神奈川）
- Year and Date
  2016-10-12
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] New molecular technologies for stabilization and activation of oligonucleotide therapeutics2016
- Author(s)
  和田猛
- Organizer
  The First Roundtable Meeting on Chemical Probe Research Hub
- Place of Presentation
  ホテルレオパレス博多（福岡）
- Year and Date
  2016-09-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] Stabilization and Activation of Double-stranded Nucleic Acid Drugs by Artificial Cationic Molecules2016
- Author(s)
  Takeshi Wada
- Organizer
  AsiaTIDES 2016
- Place of Presentation
  ウェスティン都ホテル京都（京都府京都市）
- Year and Date
  2016-02-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] RNA医薬の安定化と活性化に向けた新分子技術の開発2016
- Author(s)
  和田猛
- Organizer
  第8会日本RNAi研究会・第3回日本細胞外小胞学会
- Place of Presentation
  グランドプリンスホテル広島（広島）
- Year and Date
  2016-09-01
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬の安定化と薬理活性の向上を実現する分子技術2016
- Author(s)
  和田猛
- Organizer
  技術情報協会セミナー（No.611119）
- Place of Presentation
  技術情報協会（東京）
- Year and Date
  2016-11-25
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] New Synthetic Approaches to Oligonucleotide Therapeutics2015
- Author(s)
  Takeshi Wada
- Organizer
  Asian 3 Roundtable on Nucleic Acids 2015
- Place of Presentation
  スウォン（韓国）
- Year and Date
  2015-09-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬の安定化と高活性化へ向けた分子技術の創製2015
- Author(s)
  和田猛
- Organizer
  日本核酸医薬学会第1回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬への有機合成化学的アプローチ2015
- Author(s)
  和田猛
- Organizer
  第52回薬剤学懇談会研究討論会
- Place of Presentation
  瑠璃光（石川県加賀市）
- Year and Date
  2015-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] Stereocontrolled synthesis of boron-containing oligonucleotides as therapeutic agents2015
- Author(s)
  Takeshi Wada
- Organizer
  Pacifichem2015
- Place of Presentation
  ホノルル（アメリカ合衆国）
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03839
[Presentation] 核酸医薬への合成化学的アプローチ2014
- Author(s)
  和田猛
- Organizer
  第25回歯工学連携講演会
- Place of Presentation
  九州工業大学、北九州
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] New synthetic strategies for RNA drugs2013
- Author(s)
  和田猛
- Organizer
  第15回RNAミーティング
- Place of Presentation
  愛媛県・県民文化会館、愛媛
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 有機合成で創り出す核酸医薬への新しいアプローチ2013
- Author(s)
  和田猛
- Organizer
  第23回万有福岡シンポジウム
- Place of Presentation
  九州大学、福岡
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の立体制御、次世代医薬「核酸医薬」創出に向けた Strategy2013
- Author(s)
  和田猛
- Organizer
  次世代医薬「核酸医薬」創出に向けた Strategy
- Place of Presentation
  コクヨホール、東京
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の立体制御2013
- Author(s)
  和田猛
- Organizer
  Symposium on Innovative Research at KUT Part 1
- Place of Presentation
  高知工科大学、高知
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 医薬品を志向した機能性キラル核酸の創成2012
- Author(s)
  和田猛
- Organizer
  第40回バイオインターフェース
- Place of Presentation
  全理連ビル、東京
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Stereocontrolled synthesis and properties of P-chiral oligonucleotides2012
- Author(s)
  和田猛
- Organizer
  8th Annual Meeting of the Oligonucleotide Therapeutics Society 2012
- Place of Presentation
  ハーバード大学、アメリカ
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 薬として働く核酸分子を化学の力で組み立てる2012
- Author(s)
  和田猛
- Organizer
  第7回理研「バイオものづくり」シンポジウム
- Place of Presentation
  理化学研究所和光キャンパス(招待講演)
- Year and Date
  2012-03-08
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Synthesis and Properties of 2´-O-Haloethox- ymethyl RNA2012
- Author(s)
  和田猛
- Organizer
  第39回国際核酸化学シンポジウム
- Place of Presentation
  名古屋大学（名古屋）
- Year and Date
  2012-11-15
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 薬として働く核酸分子を化学の力で組み立てる2012
- Author(s)
  和田猛
- Organizer
  第7回理研「バイオものづくり」シンポジウム
- Place of Presentation
  理化学研究所和光キャンパス、和光市
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Stereocontrolled synthesis and properties of P-chiral oligonucleotides2012
- Author(s)
  和田猛
- Organizer
  8th Annual Meeting of the Oligonucleotide Therapeutics Society 2012
- Place of Presentation
  ボストン、アメリカ
- Year and Date
  2012-10-29
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 医薬品を志向した機能性キラル核酸の創成2012
- Author(s)
  和田猛
- Organizer
  第40回バイオインターフェース
- Place of Presentation
  全理連ビル（東京）
- Year and Date
  2012-11-12
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 2'-O-CEM基を用いるオキサザホスホリジン法によるホスホロチオェートRNAの立体選択的合成2011
- Author(s)
  額賀陽平, 山田浩平, 緒方俊彦, 和田猛
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  神奈川大学横浜キャンパス
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] 核酸医薬の新機軸2011
- Author(s)
  和田猛
- Organizer
  第38回BMBコンファレンス
- Place of Presentation
  箱根高原ホテル(神奈川県)(招待講演)
- Year and Date
  2011-07-10
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] P-Chiral Nucleic Acids as New Therapeutic Agents2011
- Author(s)
  和田猛
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)(招待講演)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] リン原子修飾核酸医薬の化学的創製2011
- Author(s)
  和田猛
- Organizer
  第8回分子複合医薬研究会
- Place of Presentation
  産業技術総合研究所関西センター(招待講演)
- Year and Date
  2011-07-10
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の化学的創製2011
- Author(s)
  和田猛
- Organizer
  第8回分子複合医薬研究会
- Place of Presentation
  産業技術総合研究所関西センター、大阪
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の化学的創製2011
- Author(s)
  和田猛
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学、東京
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の化学的創製2011
- Author(s)
  和田猛
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学・本郷キャンパス(招待講演)
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] 核酸医薬の新機軸2011
- Author(s)
  和田猛
- Organizer
  第38回BMBコンファレンス
- Place of Presentation
  箱根高原ホテル
- Year and Date
  2011-07-10
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] 核酸医薬の新機軸2011
- Author(s)
  和田猛
- Organizer
  第38回BMBコンファレンス
- Place of Presentation
  箱根高原ホテル、神奈川
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の化学的創製2011
- Author(s)
  和田猛
- Organizer
  第8回分子複合医薬研究会
- Place of Presentation
  産業技術総合研究所関西センター(大阪府)(招待講演)
- Year and Date
  2011-07-10
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] 2'-O-CEM基を用いるオキサザホスホリジン法によるホスホロチオエートRNAの立体選択的合成2011
- Author(s)
  額賀陽平, 山田浩平, 緒方俊彦, 和田猛
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  神奈川大学横浜キャンパス
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] P-Chiral Nucleic Acids as New Therapeutic Agents2011
- Author(s)
  和田猛
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、横浜
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] P-Chiral Nucleic Acids as New Therapeutic Agents2011
- Author(s)
  和田猛
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] リン原子修飾核酸医薬の化学的創製2011
- Author(s)
  和田猛
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学・本郷キャンパス(招待講演)
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] P-Chiral Nucleic Acids as New Therapeutic Agents2011
- Author(s)
  和田猛
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(招待講演)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の化学的創製2011
- Author(s)
  和田猛
- Organizer
  第8回分子複合医薬研究会
- Place of Presentation
  産業技術総合研究所関西センター
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] リン原子修飾核酸医薬の化学的創製2011
- Author(s)
  和田猛
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] 核酸医薬の新機軸2011
- Author(s)
  和田猛
- Organizer
  第38回BMBコンファレンス
- Place of Presentation
  箱根高原ホテル(招待講演)
- Year and Date
  2011-07-10
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Stereocontrolled synthesis of P-chiral nucleic acid analogs as therapeutic agents2010
- Author(s)
  Wada, T.
- Organizer
  Asian 3 Roundtable on Nucleic Acids
- Place of Presentation
  関西国際空港会議場
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] H-ボラノホスホネートDNA類縁体の合成と変換反応2010
- Author(s)
  植原渉, 日浦進吾, 東田廉平, 岡夏央, 和田猛
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] β,γ-ジアミノ酸骨格を有する新規ペプチド核酸の合成2010
- Author(s)
  斉藤敬太, 堀江暁, 岩田倫太朗, 緒方俊彦, 岡夏央, 和田猛
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] New aspects for the chemical synthesis of backbone-modified nucleicacids as therapeutic agents2010
- Author(s)
  Wada, T.
- Organizer
  2010 The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  ハワイコンベンションセンター(ホノルル,アメリカ)
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] H-ボラノホスホネートDNA類縁体の合成と変換反応2010
- Author(s)
  植原渉, 日浦進吾, 東田廉平, 岡夏央, 和田猛
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] 2'-O-アルコキシメチル修飾型新規アンチセンス核酸の合成と性質2010
- Author(s)
  新井浩一郎, 内山直樹, 和田猛
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] New method for the synthesis of 2'-O-arylmethyluridine derivatives2010
- Author(s)
  Uchiyama, N., Ogata, T., Oka, N., Wada, T.
- Organizer
  The 37th International Symposium on Nucleic Acids Chemistry 2010
- Place of Presentation
  みなとみらい・はまぎんホール(横浜)
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Bis(trifluoromethyl)ethoxymethyl (BFEM) group as a novel 2'-OH protecting group for RNA synthesis2010
- Author(s)
  Shimizu, M., Nishina, Y., Ozaki, K., Wada, T.
- Organizer
  2010 The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  ハワイコンベンションセンター (ホナルル,アメリカ)
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] New method for the synthesis of 2'-O-arylmethyluridine derivatives2010
- Author(s)
  Uchiyama, N., Ogata, T., Oka, N., Wada, T.
- Organizer
  The 37th International Symposium on Nucleic Acids Chemistry 2010
- Place of Presentation
  みなとみらい・はまぎんホール(横浜)
- Year and Date
  2010-11-10
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] β,γ-ジアミノ酸骨格を有する新規ペプチド核酸の合成2010
- Author(s)
  斉藤敬太, 堀江暁, 岩田倫太朗, 緒方俊彦, 岡夏央, 和田猛
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Bis(trifluoromethyl)ethoxymethyl (BFEM) group as a novel 2'-OH protecting group for RNA synthesis2010
- Author(s)
  Shimizu, M., Nishina, Y., Ozaki, K., Wada, T.
- Organizer
  2010 The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  ハワイコンベンションセンター(ホノルル、アメリカ)
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Stereocontrolled synthesis of P-chiral nucleic acid analogs as therapeutic agents2010
- Author(s)
  Wada, T.
- Organizer
  Asian 3 Roundtable on Nucleic Acids
- Place of Presentation
  関西国際空港会議場
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] Synthesis of stereoregulated 2'-O-Me phosphorothioate oligoribonucleotides2010
- Author(s)
  Khandelwal, N., Iwamoto, N., Kondo, T., Oka, N., Wada, T.
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 2'-O-アルコキシメチル修飾型新規アンチセンス核酸の合成と性質2010
- Author(s)
  新井浩一郎, 内山直樹, 和田猛
- Organizer
  第20回アンチセンスシシポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] Synthesis of stereoregulated 2'-O-Me phosphorothioate oligoribonucleotides2010
- Author(s)
  Khandelwal, N., Iwamoto, N., Kondo , T., Oka, N., Wada, T.
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  甲南大学
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] New aspects for the chemical synthesis of backbone-modified nucleic acids as therapeutic agents2010
- Author(s)
  Wada, T.
- Organizer
  2010 The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  ハワイコンベンションセンター(ホノルル、アメリカ)
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] New aspects for the chemical synthesis of backbone-modified nucleic acids as therapeutic agents2010
- Author(s)
  和田猛
- Organizer
  2010 The International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  ハワイコンベンションセンター、アメリカ
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Stereocontrolled synthesis of oligodeoxy-ribonucleoside phosphorothioates using light fluorus chemistry2009
- Author(s)
  Wada, T.
- Organizer
  19th International Symposium on Fluorine Chemistry
- Place of Presentation
  アメリカ、ワイオミング州、ジャクソンホール
- Year and Date
  2009-08-25
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Recent Progress of Stereocontrolled Synthesis of Backbone-modified Nucleic Acids2009
- Author(s)
  Wada, T.
- Organizer
  Joint Symposium of 5th Annual Meeting of Oligonucleotide Therapeutics Society and the 19th Antisense Symposium
- Place of Presentation
  九州大学
- Year and Date
  2009-09-28
- Data Source
  KAKENHI-PROJECT-21350088
[Presentation] リン原子の立体を制御したPS/POキメラオリゴヌクレオチドの固相合成2008
- Author(s)
  岡夏央・山本美佳・佐藤輝聴・和田猛
- Organizer
  日本化学会第88春季年会
- Place of Presentation
  立教大学池袋キャンパス
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-16350085
[Presentation] H-ホスホネートDNAの立体選択的合成とインターヌクレオチド修飾型DNA類縁体への変換反応2008
- Author(s)
  岩本直樹・岡夏央・和田猛
- Organizer
  日本化学会第88春季年会
- Place of Presentation
  立教大学池袋キャンパス
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-16350085
[Presentation] Chemical synthesis and properties of stereoregulated phosphorothioate RNA2007
- Author(s)
  Wada T., Kondo, T., Fujiwara, S., Sato, T., Oka, N
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京大学本郷キャンパス
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-16350085
[Presentation] 立体が制御されたホスホロチオエートRNAの化学合成と性質2007
- Author(s)
  和田猛, 近藤知明, 藤原聡, 佐藤輝聴, 岡夏央
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京大学
- Year and Date
  2007-11-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16350085
[Presentation] Stereocontrolled synthesis of phosphorothioate DNA and RNA by the oxazaphospholidine approach2007
- Author(s)
  Wada T
- Organizer
  第17回国際リン化学シンポジウム
- Place of Presentation
  Xiamen University
- Year and Date
  2007-04-16
- Data Source
  KAKENHI-PROJECT-16350085
[Presentation] 有機合成で創り出す核酸医薬への新しいアプローチ
- Author(s)
  和田猛
- Organizer
  第23回万有福岡シンポジウム
- Place of Presentation
  九州大学
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の立体制御、次世代医薬「核酸医薬」創出に向けたStrategy
- Author(s)
  和田猛
- Organizer
  次世代医薬「核酸医薬」創出に向けたStrategy
- Place of Presentation
  品川コクヨホール
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] New synthetic strategies for RNA drugs
- Author(s)
  和田猛
- Organizer
  第15回RNAミーティング
- Place of Presentation
  愛媛県・県民文化会館・ひめぎんホール
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾型核酸の立体選択的合成のための新規保護基の開発
- Author(s)
  濱村友香、額賀陽平、和田猛
- Organizer
  日本化学会第94春季年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] Synthesis of Boron-Containing Antisense Molecules by the H-Boranophosphonate Method
- Author(s)
  植原渉、日浦進吾、東田廉平、岡夏央、和田猛
- Organizer
  40回国際核酸化学シンポジウム
- Place of Presentation
  神奈川大学
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 核酸医薬への合成化学的アプローチ
- Author(s)
  和田猛
- Organizer
  第25回歯工学連携講演会
- Place of Presentation
  九州工業大学
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] 2'-O-CEM保護H-ボラノホスホネート法によるボラン修飾型RNA類縁体の固相合成
- Author(s)
  和田猛、伊藤弘暁、首藤智仁、植原渉
- Organizer
  日本化学会第94春季年会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾核酸医薬の立体制御
- Author(s)
  和田猛
- Organizer
  Symposium on Innovative Research at KUT Part 1
- Place of Presentation
  高知工科大学
- Invited
- Data Source
  KAKENHI-PLANNED-21115008
[Presentation] リン原子修飾糖1-リン酸誘導体の立体選択的合成
- Author(s)
  野呂美穗子、藤田正一、和田猛
- Organizer
  第32回日本糖質学会年会
- Place of Presentation
  大阪国際交流センター
- Data Source
  KAKENHI-PLANNED-21115008

1. SEKINE Mitsuo (40111679)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. TAKESHITA Fumitaka (40466199)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. ISHIKAWA Masahide (50212858)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Taniuchi Keisuke (50626869)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. TOMARI Yukihide (90447368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KAGEYAMA Yuji (90335480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SUZUKI Takeo (90533125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. TEI Kumiko (50213327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKAZAWA Takanobu (00447335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SADO Takashi (70321601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SIOMI Mikiko (20322745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MIYAGAWA Satomi (90291153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKAGAWA Shinichi (50324679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ODA Takeaki (00608523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YAMASHITA Akio (20405020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NISHIMURA Yukiko (30514567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Komoda Masayo (50167409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. 西川一八 (60109262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 山本美智子 (90538125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 後藤惠子 (40434047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 真野泰成 (60406254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. 根岸健一 (20286363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 宮崎智 (30290894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 坪井麻記子 (90833905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. KIDA Masahide

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. Suzuki Tsutomu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. Yokota Takanori

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
28. Hara Rintaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
29. 高橋秀臣

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. MIYATA Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. YOSHIDA Mari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 和田健彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 岡夏央

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
34. 内原俊記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Wada Takeshi 和田 猛

WADA TAKESHI 和田 猛

WADA Takeshi 和田 猛

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Development of sterically controlled boranophosphate nucleic acid drugs with both high potency and low toxicityPrincipal Investigator

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Molecule selection and optimization of highly active antisense DNA and determination of absolute configuration of phosphorus atomsPrincipal Investigator

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Medicinal Application of Functional Machinery for non-coding RNAsPrincipal Investigator

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Stereocontrolled synthesis of P-modified RNA nucleic acid drugsPrincipal Investigator

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New synthetic methods for the large scale synthesis of nucleic acid drugsPrincipal Investigator

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Synthesis and properties of novel artificial nucleic acid analogs having chiral backbonesPrincipal Investigator

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ボラノホスフェートDNAを用いるHIV-nefタンパク質の発現制御Principal Investigator

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Highly Efficient Synthesis of Artificial Nucleic Acids Having New FunctionsPrincipal Investigator

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修飾塩基を含むRNAの化学合成Principal Investigator

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新規アンチセンス核酸を用いるHIV-nefタンパク質の発現制御Principal Investigator

Wada Takeshi 和田猛

WADA TAKESHI 和田猛

WADA Takeshi 和田猛