Ikehata Hironobu 池畑広伸

… Alternative Names

IKEHATA Hironobu 池畑広伸

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Researcher Number	90250737
Other IDs
Affiliation (Current)	2025: 東北大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2024: 東北大学, 医学系研究科, 准教授 2022: 東北大学, 医学系研究科, 准教授 2020 – 2021: 東北大学, 医学系研究科, 講師 2016 – 2017: 東北大学, 医学系研究科, 講師 2012 – 2015: 東北大学, 医学(系)研究科(研究院), 講師 … More 2012: 東北大学, 大学院・医学系研究科, 講師 2011: 東北大学, 医学(系)研究科(研究院), 助教 1999 – 2005: 東北大学, 大学院・医学系研究科, 助手 2002: Grad, Sch. Med., Genome Radial. Biol., Research Associate, 大学院・医学研究科, 助手 1993 – 1998: Tohoku University School of Medicine, Res. Asooc., 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Risk sciences of radiation/Chemicals / 環境影響評価(含放射線生物学) / Basic Section 63020:Radiation influence-related / Risk sciences of radiation and chemicals Except Principal Investigator Radiation science / Risk sciences of radiation/Chemicals / 放射線5生物学 / Dermatology / General medical chemistry / 老化(加齢)
Keywords	Principal Investigator 紫外線 / 皮膚 / 突然変異 / UV / 皮膚がん / トランスジェニックマウス / DNA損傷 / skin cancer / transgenic mouse / skin … More / mutation / オゾン層 / 遺伝子組換えマウス / アポトーシス / MIS応答 / 環境 / ゲノム毒性 / メラニン / 細胞･組織 / Mrf2 / 細胞・組織 / 環境応答 / 活性酸素 / Nrf2 / stratospheric ozone layer / statospheric ozone layer / 皮膚癌 / Skin cancer / Transgenic mouse / Skin / Mutation / 光化学反応 / 光化学 / 光生物学 / ユビキチン / DNA修復 / 温度感受性変異株 … More Except Principal Investigator 突然変異 / 放射線 / トランスジェニックマウス / lacZ / DNA-PK / ataxia telangiectasia / mismatch repair / mutation / mouse / ミスマッチ修復 / マウス / wortmannin / phosphatidylinositol 3-kinase / mitomycin / bleomycin / 低線量 / ATM / X線 / Mutaマウス / 癌化 / 環境変異原 / 老化 / DNAメチル化 / biological significance / 染色体 / 生物学的意義 / deletion / germ-line cells / testis / 精細胞 / 精原細胞 / 減数分裂 / 自然突然変異 / 欠失変異 / 生殖細胞 / 睾丸 / radiation sensitivity / ionizing radiation / scidマウス / PI-3キナーゼ / 放射線感受性 / Cell Communication / Growth Factor / Immuno-modulator / Prevention of Hazards / Acute Effects / Radiation / 抗生物質 / 免疫賦活剤 / 骨髄死 / 放射線障害 / 血管内皮細胞 / フォトブリーチング / ギャップジャンクション / 腸死 / 脾臓 / 適応応答 / Ku80 / Ku70 / 皮膚 / 太陽光 / 紫外線 / 毛細血管拡張性運動失調症 / アンチセンス / AT / 反復照射 / 急照射 / SV40 / ATDC / DNAメチルトランスフェラーゼ / 大量1回被曝 / 少量長期被曝 / 遺伝子 / 体細胞突然変異 Less

Analysis of the basic mechanism of tissue damage and mutation accumulation in UVR-exposed skinPrincipal Investigator
- Principal Investigator
  
  池畑広伸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Tohoku University
Estimation of UV toxicity for the genome of skin with defective melanin synthesis and the elucidation of its mechanismPrincipal Investigator
- Principal Investigator
  
  Ikehata Hironobu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Tohoku University
Mecahistic analysis of a protective response of skin tissue to UV genotoxicityPrincipal Investigator
- Principal Investigator
  
  IKEHATA Hironobu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Tohoku University
Analysis of the mechanism of tissue-specific protection of skin against the genotoxicity of ultraviolet radiationPrincipal Investigator
- Principal Investigator
  
  IKEHATA Hironobu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
Demonstration of the formation of cyclobutane pyrimidine dimers through the excited triplet state mediated by solar UV radiationPrincipal Investigator
- Principal Investigator
  
  IKEHATA Hironobu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
Analysis of biological significance of elevated mutation
- Principal Investigator
  
  ONO Tetsuya
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
Analysis of the mechanism of a defensive response newly found in skin epidermis to the mutagenic effect of UV.Principal Investigator
- Principal Investigator
  
  IKEHATA Hironobu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
Action spectrum of UV-induced mutation in skinPrincipal Investigator
- Principal Investigator
  
  IKEHATA Hironobu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Tohoku University
Characteristics of spontaneous mutations in mouse germ cells
- Principal Investigator
  
  ONO Tetsuya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Tohoku University
Analysis of mutation induced in UV-irradiated skinPrincipal Investigator
- Principal Investigator
  
  IKEHATA Hironobu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Tohoku University
低線量放射線による適応応答は個体レベルでの突然変異誘発にも働くか
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Effect of a phosphatidylinositol 3-kinase inhibitor wortmannin on radiation and bleomycin sensitivities.
- Principal Investigator
  
  HOSOI Yoshio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
少量の変異原にさらされた時の遺伝子への影響
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
アンチセンスATM遺伝子治療による放射線増感効果
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
皮膚における紫外線誘発突然変異
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Tohoku University
アンチセンスKup70/80DNAを用いた放射線遺伝子治療
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
少量の変異原に長期間さらされた時の遺伝子への影響
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
DNAメチルトランスフェラーゼ活性の老化への関与
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
ヒト腫瘍の放射線感受性因子としてのATDC遺伝子発現の関与
- Principal Investigator
  
  HOSOI Yoshio
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
個体の老化に伴う遺伝的変化とエピジェネティックな変化の比較
- Principal Investigator
  
  ONO Tetsuya
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Tohoku University
哺乳類細胞におけるユビキチン活性化系のDNA修復への関与Principal Investigator
- Principal Investigator
  
  池畑広伸
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Tohoku University
A search of methods to enhance the capacity to resist against radiation-induced acute injuries.
- Principal Investigator
  
  ONO Tetsuya
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  TOHOKU UNIVERSITY

All 2022 2021 2018 2017 2016 2015 2014 2013 2012 2011 2004 2003 Other

All Journal Article Presentation Book

[Book] 光と生命の事典2016
- Author(s)
  池畑広伸，真嶋哲朗、飯野盛利、七田芳則、藤堂剛、秋山（張）秋梅、伊吹裕子、森俊雄、日出間純、錦織千佳子、守田明理、竹内聖二、大平明弘、上出良一、田中淳、船坂陽子、渡辺正勝、森脇真一、菅澤薰、寺西美佳，松永司、安倍学、蟻川謙太郎、安東宏徳、飯郷雅之、池内昌彦、池田憲昭、池田啓、井澤毅、石川大太郎、石川満　他（共著）
- Total Pages
  422
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-15H02815
[Journal Article] Cyclobutane pyrimidine dimers produced with narrowband UVB are on average more mutagenic than those with broadband UVB in mouse skin2022
- Author(s)
  H. Ikehata, M. Yamamoto
- Journal Title
  
  Photochemistry and Photobiology
  
  Volume: 98 Issue: 4 Pages: 916-924
- DOI
  10.1111/php.13568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K12158
[Journal Article] Mechanistic considerations on the wavelength-dependent variations of UVR genotoxicity and mutagenesis in skin: Discrimination of UVA-signature from UV-signature mutation2018
- Author(s)
  H. Ikehata
- Journal Title
  
  Photochemical and Photobiological Sciences
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02815
[Journal Article] Quantitative analysis of UV photolesions suggests that cyclobutane pyrimidine dimers produced in mouse skin by UVB are more mutagenic than those produced by UVC.2018
- Author(s)
  H. Ikehata, T. Mori, T. Douki, J. Cadet, M. Yamamoto
- Journal Title
  
  Photochemical and Photobiological Sciences
  
  Volume: 17 Pages: 404-413
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02815
[Journal Article] Wavelength dependence of UVR-induced mutation spectrum in mouse skin.2016
- Author(s)
  H. Ikehata
- Journal Title
  
  Photomedicine and Photobiology
  
  Volume: 38 Pages: 1-2
- Data Source
  KAKENHI-PROJECT-15H02815
[Journal Article] In vivo spectrum of UVC-induced mutation in mouse skin epidermis may reflect the cytosine deamination propensity of cyclobutane pyrimidine dimers.2015
- Author(s)
  H. Ikehata, T. Mori and M. Yamamoto
- Journal Title
  
  Photochem. Photobiol.
  
  Volume: 91 Issue: 6 Pages: 1488-1496
- DOI
  10.1111/php.12525
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26550042, KAKENHI-PROJECT-15H02815
[Journal Article] マウス皮膚における紫外線突然変異作用スペクトルの解析2014
- Author(s)
  池畑広伸
- Journal Title
  
  放射線生物研究
  
  Volume: 49 Pages: 1-13
- NAID
  40020050262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310036
[Journal Article] Remarkable induction of UV-signature mutations at the 3'-cytosine of dipyrimidine sites except at 5'-TCG-3' in the UVB-exposed skin epidermis of xeroderma pigmentosum variant model mice.2014
- Author(s)
  Ikehata H, Chang Y, Yokoi M, Yamamoto M, Hanaoka F
- Journal Title
  
  DNA Repair
  
  Volume: 22 Pages: 112-122
- DOI
  10.1016/j.dnarep.2014.07.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22131008, KAKENHI-PROJECT-24310036, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26340028
[Journal Article] Comparison of the Solar-UV-Signature Mutations Detected in the p53 Gene between Mouse and Human Skin Cancers.2013
- Author(s)
  H. Ikehata
- Journal Title
  
  Photomedicine and Photobiology
  
  Volume: 35 Pages: 23-24
- Data Source
  KAKENHI-PROJECT-24310036
[Journal Article] Solar-UV-signature mutation prefers TCG to CCG: extrapolative consideration from UVA1-induced mutation spectra in mouse skin2013
- Author(s)
  H. Ikehata, J. Kumagai, T. Ono & A. Morita
- Journal Title
  
  Photochem. Photobiol. Sci. inpress
  
  Volume: 12 Issue: 8 Pages: 1319-1327
- DOI
  10.1039/c3pp25444e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651044, KAKENHI-PROJECT-24310036
[Journal Article] Action spectrum analysis of UVR genotoxicity for skin: the border wavelengths between UVA and UVB can bring serious mutation loads to skin2013
- Author(s)
  H. Ikehata, S. Higashi, S. Nakamura, Y.Daigaku, Y. Furusawa, Y. Kamei, M. Watanabe, K. Yamamoto, K. Hieda, N. Munakata & T. Ono
- Journal Title
  
  J. Invest. Dermatol
  
  Volume: 133 Issue: 7 Pages: 1850-1856
- DOI
  10.1038/jid.2012.504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651044, KAKENHI-PROJECT-24310036
[Journal Article] Skin can control solar UVR-induced mutations through the epidermis-specific response of mutation induction suppression.2013
- Author(s)
  H. Ikehata, N. Munakata, T. Ono
- Journal Title
  
  Photochemical & Photobiological Sciences
  
  Volume: 12 Issue: 11 Pages: 2008-2015
- DOI
  10.1039/c3pp50158b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24310036
[Journal Article] Significance of Erythema for the Response of Mutation Induction Suppression in UV-exposed Skin2012
- Author(s)
  H. Ikehata, S. Higashi & Y. Kamei
- Journal Title
  
  Photomed. Photobiol
  
  Volume: 34 Pages: 39-40
- URL
  http://square.umin.ac.jp/jspp/member/proceed/proceedings.pdf
- Data Source
  KAKENHI-PROJECT-23651044
[Journal Article] 紫外線誘発突然変異の波長依存性2012
- Author(s)
  池畑広伸
- Journal Title
  
  太陽紫外線防御研究委員会学術報告
  
  Volume: 22(1) Pages: 25-29
- NAID
  40016597008
- Data Source
  KAKENHI-PROJECT-23651044
[Journal Article] Fully functional global genome repair of (6-4) photoproducts and compromised transcription-coupled repair of cyclobutane pyrimidine dimers in condensed mitotic chromatin2012
- Author(s)
  J.Komura
- Journal Title
  
  Exp.Cell Res.
  
  Volume: 318 Issue: 5 Pages: 623-631
- DOI
  10.1016/j.yexcr.2012.01.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570177, KAKENHI-PROJECT-23510081, KAKENHI-PROJECT-23651044
[Journal Article] Significance of Erythema for the Response of Mutation Induction Suppression in UV-exposed Skin.2012
- Author(s)
  H. Ikehata, S. Higashi, Y. Kamei
- Journal Title
  
  Photomed. Photobiol.
  
  Volume: 34 Pages: 39-40
- Data Source
  KAKENHI-PROJECT-24310036
[Journal Article] 紫外線防御化粧品の性能評価―皮膚ゲノム毒性を指標とした新たな評価法2011
- Author(s)
  池畑広伸
- Journal Title
  
  Fragrance Journal
  
  Volume: 39 (7) Pages: 32-37
- Data Source
  KAKENHI-PROJECT-23651044
[Journal Article] Quantitative assessment of the genotoxicity in skin exposed to solar UV2011
- Author(s)
  H. Ikehata, S. Higashi, Y. Kamei & T. Ono
- Journal Title
  
  Photomed. Photobiol
  
  Volume: 33 Pages: 19-20
- Data Source
  KAKENHI-PROJECT-23651044
[Journal Article] 紫外線防御化粧品の性能評価-皮膚ゲノム毒性を指標とした新たな評価法2011
- Author(s)
  池畑広伸
- Journal Title
  
  Fragrance Journal
  
  Volume: 39(7) Pages: 32-37
- URL
  http://www.fragrance-j.co.jp/magazine/fragrance_backno_201107.html
- Data Source
  KAKENHI-PROJECT-23651044
[Journal Article] Quantitative assessment of the genotoxicity...2011
- Author(s)
  H. Ikehata, S. Higashi, Y. Kamei & T. Ono
- Journal Title
  
  Photomed. Photobiol.
  
  Volume: 33 Pages: 19-20
- Data Source
  KAKENHI-PROJECT-23651044
[Journal Article] Mutation spectrum in sunlight-exposed mouse skin epidermis : small but appreciable contribution of oxidative stress-mediated mutagenesis.2004
- Author(s)
  Hironobu Ikehata
- Journal Title
  
  Mutation Research 556・1-2
  
  Pages: 11-24
- Data Source
  KAKENHI-PROJECT-15310031
[Journal Article] Mutation spectrum in sunlight-exposed skin epidermis : small but appreciable contribution of oxidative stress-induced mutagenesis.2004
- Author(s)
  Hironobu Ikehata
- Journal Title
  
  Mutation Research 556
  
  Pages: 11-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510040
[Journal Article] Mutation spectrum in sunlight-exposed skin epidermis : small but appreciable contribution of oxidative stress-induced mutagenesis.2004
- Author(s)
  Ikehata, H., S.Nakamura, T.Asamura, T.Ono
- Journal Title
  
  Mutat.Res. 556
  
  Pages: 11-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510040
[Journal Article] UVA induces C -> T transitions at methyl CpG-associated dipyrimidine sites in mouse skin epidermis more frequently than UVB.2003
- Author(s)
  Hironobu Ikehata
- Journal Title
  
  Mutagenesis 18
  
  Pages: 511-519
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510040
[Journal Article] Analysis of mutation spectrum in UVB-exposed mouse skin epidermis and dermis : frequent occurrence of C -> T transition at methylated CpG-associated dipyrimidine sites.2003
- Author(s)
  Hironobu Ikehata
- Journal Title
  
  Environmental and Molecular Mutagenesis 41
  
  Pages: 280-292
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15510040
[Journal Article] UVA induces C → T transitions at methyl CpG-associated dipyrimidine sites in mouse skin epidermis more frequently than UVB.2003
- Author(s)
  Ikehata, H., H.Kudo, T.Masuda, T.Ono
- Journal Title
  
  Mutagenesis 18
  
  Pages: 511-519
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510040
[Journal Article] Analysis of mutation spectra in UVB-exposed mouse skin epidermis and dermis : frequent occurrence of C → T transition at methylated CpG-associated dipyrimidine sites.2003
- Author(s)
  Ikehata, H., T.Masuda, H.Sakata, T.Ono
- Journal Title
  
  Environ.Mol.Mutagen. 41
  
  Pages: 280-292
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15510040
[Journal Article] UVA induces C->T transitions at methyl-CpG-associated dipyrimidine sites in mouse skin epidermis more frequently than UVB.2003
- Author(s)
  H.Ikehata
- Journal Title
  
  Mutagenesis 18
  
  Pages: 511-519
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15310031
[Presentation] 紫外線に対するメラニンのマウス皮膚ゲノム防護能の評価2022
- Author(s)
  池畑広伸、山本雅之
- Organizer
  日本放射線影響学会第65回大会
- Data Source
  KAKENHI-PROJECT-20K12158
[Presentation] 広帯域UVBと狭帯域UVBの皮膚ゲノム毒性の違いはシクロブタン型ピリミジンダイマー生成の有効波長の違いにある2021
- Author(s)
  池畑広伸、山本雅之
- Organizer
  第43回日本光医学・光生物学会
- Data Source
  KAKENHI-PROJECT-20K12158
[Presentation] 紫外線の突然変異スペクトルと皮膚がん特異的突然変異2017
- Author(s)
  池畑広伸
- Organizer
  太陽紫外線防御研究委員会第27回シンポジウム
- Place of Presentation
  大阪大学中之島センター（大阪市）
- Year and Date
  2017-03-17
- Invited
- Data Source
  KAKENHI-PROJECT-15H02815
[Presentation] マウス皮膚に対する広帯域および狭帯域UVBのゲノム毒性の比較2017
- Author(s)
  池畑広伸, 森俊雄, 山本雅之
- Organizer
  第39回日本光医学・光生物学会
- Data Source
  KAKENHI-PROJECT-15H02815
[Presentation] マウス皮膚における紫外線DNA損傷量と誘発突然変異頻度の定量的関係の解析2017
- Author(s)
  池畑広伸，森俊雄，山本雅之
- Organizer
  日本放射線影響学会第60回大会
- Data Source
  KAKENHI-PROJECT-15H02815
[Presentation] マウス皮膚におけるUVCゲノム毒性の解析　-突然変異スペクトルの波長依存性-2016
- Author(s)
  池畑広伸
- Organizer
  第38回日本光医学・光生物学会
- Place of Presentation
  京都リサーチパーク（京都市）
- Year and Date
  2016-07-22
- Invited
- Data Source
  KAKENHI-PROJECT-15H02815
[Presentation] 紫外線DNA損傷特異抗体を利用したマウス皮膚における損傷量と誘発突然変異頻度の定量的関係の解析2016
- Author(s)
  池畑広伸
- Organizer
  日本放射線影響学会第59回大会,
- Place of Presentation
  JMSアステールプラザ（広島市）
- Year and Date
  2016-10-26
- Invited
- Data Source
  KAKENHI-PROJECT-15H02815
[Presentation] 紫外線ゲノム毒性に対するKEAP1-NRF2系の皮膚防護能2016
- Author(s)
  池畑広伸、山田亮太郎、山本雅之
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15H02815
[Presentation] Wavelength dependence of UV photolesion formation and mutagenesis in skin2015
- Author(s)
  Hironobu Ikehata
- Organizer
  European Society for Photobiology Congress
- Place of Presentation
  Aveiro, Portugal
- Year and Date
  2015-09-03
- Invited
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] In vivo analysis of UVC-induced mutation in mouse skin: dose-dependent induction kinetics and mutation spectrum.2015
- Author(s)
  H. Ikehata, T. Mori, M. Yamamoto
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  京都国際会議場（京都市）
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02815
[Presentation] Wavelength dependence of UV photolesion formation and mutagenesis in skin.2015
- Author(s)
  H. Ikehata
- Organizer
  16th Congress of the European Society for Photobiology
- Place of Presentation
  Aveiro, Portugal
- Year and Date
  2015-08-31
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02815
[Presentation] マウス皮膚におけるUVCゲノム毒性の解析2015
- Author(s)
  池畑広伸、森俊雄、山本雅之
- Organizer
  第37回日本光医学･光生物学会
- Place of Presentation
  シーガイアコンベンションセンター（宮崎市）
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-15H02815
[Presentation] Why do solar-UV signature mutations occur preferentially at TCG context?2014
- Author(s)
  Hironobu Ikehata
- Organizer
  37th Meeting of the American Society for Photobiology
- Place of Presentation
  Hard Rock Hotel, San Diego, USA
- Year and Date
  2014-06-19
- Invited
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] Wavelength dependent antigenotoxic response to UVR in skin epidermis.2014
- Author(s)
  Hironobu Ikehata
- Organizer
  16th International Congress on Photobiology
- Place of Presentation
  Universidad Nacional de Cordoba, Cordoba, Argentina
- Year and Date
  2014-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] 色素性乾皮症バリアント群モデルマウス皮膚におけるUVB誘発突然変異スペクトルの解析2014
- Author(s)
  池畑広伸、横井雅幸、山本雅之、花岡文雄
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  かごしま県民交流センター、鹿児島市
- Year and Date
  2014-10-01
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] In vivo UVB-induced mutation spectrum in the skin epidermis of XP variant model mice2014
- Author(s)
  H. Ikehata, M. Yokoi, M. Yamamoto, F. Hanaoka
- Organizer
  International Symposium on Xeroderma Pigmentosum and Related Diseases: Disorders of DNA Damage Response -Bench to Bedside-
- Place of Presentation
  Kobe International Conference Center, Kobe, Japan
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] 紫外線の皮膚ゲノム毒性―マウスを用いた解析2013
- Author(s)
  池畑広伸
- Organizer
  日本環境変異原学会第42回大会
- Place of Presentation
  岡山コンベンションセンター、岡山市
- Invited
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] MIS応答波長依存性に基づく紫外線治療法デザインの提案2013
- Author(s)
  池畑広伸
- Organizer
  第2回光皮膚科学研究会
- Place of Presentation
  名古屋市
- Year and Date
  2013-02-17
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] マウス皮膚における紫外線特異的DNA損傷誘発の作用スペクトル解析2013
- Author(s)
  池畑広伸、森俊雄、東正一、亀井保博、山本雅之
- Organizer
  日本放射線影響学会第56回大会
- Place of Presentation
  ホテルクラウンパレス青森、青森市
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] Action spectrum analysis of UVR-induced mutation in mouse skin2013
- Author(s)
  Hironobu Ikehata
- Organizer
  The 6th Asia and Oceania Conference on Photobiology
- Place of Presentation
  Novotel Sydney Central, Sydney, Australia
- Invited
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] MIS応答波長依存性に基づく紫外線治療法デザインの提案2013
- Author(s)
  池畑広伸
- Organizer
  第2回光皮膚科学研究会
- Place of Presentation
  名古屋
- Year and Date
  2013-02-17
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] 皮膚がんp53遺伝子変異に見られる日光紫外線特異的突然変異の特徴2013
- Author(s)
  池畑広伸
- Organizer
  第35回日本光医学･光生物学会
- Place of Presentation
  アクトシティ浜松コングレスセンター、浜松市
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] 紫外線と放射線-何が違うか2012
- Author(s)
  池畑広伸
- Organizer
  光皮膚科学研究会設立大会
- Place of Presentation
  東京
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] 紫外線と放射線―何が違うか―2012
- Author(s)
  池畑広伸
- Organizer
  光皮膚科学研究会設立大会(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] Identification and characterization of the response of mutation induction suppression (MIS) in mouse epidermis2012
- Author(s)
  H. Ikehata
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  兵庫県淡路島
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] 紫外線誘発突然変異の波長依存性2012
- Author(s)
  池畑広伸
- Organizer
  太陽紫外線防御研究委員会第22回シンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] 生体皮膚における紫外線ゲノム毒性に対する応答2012
- Author(s)
  池畑広伸
- Organizer
  日本放射線影響学会第55回大会
- Place of Presentation
  仙台市(招待講演)
- Year and Date
  2012-09-06
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] M期の凝縮した染色体におけるDNA二本鎖切断の修復とその影響2012
- Author(s)
  小村潤一郎, 池畑広伸, 小野哲也
- Organizer
  日本放射線影響学会第55回大会
- Place of Presentation
  仙台市
- Year and Date
  2012-09-08
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] 皮膚における紫外線に対する変異誘発抑制応答と紅斑反応の関連2012
- Author(s)
  池畑広伸, 東正一, 亀井保博
- Organizer
  第34回日本光医学・光生物学会
- Place of Presentation
  神戸市ポートアイランド
- Year and Date
  2012-07-27
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] Identification and characterization of the response of mutation induction suppression (MIS) in mouse epidermis2012
- Author(s)
  Hironobu Ikehata
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  兵庫県淡路島
- Year and Date
  2012-11-27
- Data Source
  KAKENHI-PROJECT-24310036
[Presentation] M期の凝縮した染色体におけるDNA二本鎖切断の修復とその影響2012
- Author(s)
  小村潤一郎、池畑広伸、小野哲也
- Organizer
  影響学会第55回大会
- Place of Presentation
  仙台
- Year and Date
  2012-09-08
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] 生体皮膚における紫外線ゲノム毒性に対する応答2012
- Author(s)
  池畑広伸
- Organizer
  影響学会第55回大会
- Place of Presentation
  仙台
- Year and Date
  2012-09-06
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] 紫外線誘発突然変異の波長依存性2012
- Author(s)
  池畑広伸
- Organizer
  太陽紫外線防御研究委員会第22回シンポジウム(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] 皮膚における紫外線に対する変異誘発抑制応答と紅斑反応の関連2012
- Author(s)
  池畑広伸、東正一、亀井保博
- Organizer
  第34回日本光医学・光生物学会
- Place of Presentation
  神戸
- Year and Date
  2012-07-27
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] 突然変異を指標にした太陽紫外線皮膚ゲノム毒性評価2011
- Author(s)
  池畑広伸、東正一、亀井保博、小野哲也
- Organizer
  日本放射線影響学会第54回大会
- Place of Presentation
  神戸
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] Risk estimation of the solar-UV genotoxicity...2011
- Author(s)
  H. Ikehata
- Organizer
  5th Asia Oceania Conference on Photobiology(招待講演)
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] 突然変異作用スペクトルに基づく太陽紫外線皮膚ゲノム毒性の評価2011
- Author(s)
  池畑広伸，東正一，亀井保博，小野哲也
- Organizer
  第33回日本光医学･光生物学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] M期の凝縮した染色体におけるDNA修復:効率的なゲノム全体の除去修復と不活性な転写共役修復2011
- Author(s)
  小村潤一郎、池畑広伸、森俊雄、小野哲也
- Organizer
  影響学会第54回大会
- Place of Presentation
  神戸
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] 突然変異作用スペクトルに基づく太陽紫外線皮膚ゲノム毒性の評価2011
- Author(s)
  池畑広伸、東正一、亀井保博、小野哲也
- Organizer
  第33回日本光医学・光生物学会
- Place of Presentation
  大阪
- Year and Date
  2011-07-22
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] Risk estimation of the solar-UV genotoxicity for skin2011
- Author(s)
  H. Ikehata
- Organizer
  5th Asia Oceania Conference on Photobiology
- Place of Presentation
  奈良
- Year and Date
  2011-07-30
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] MIS応答波長依存性に基づく紫外線治療法デザインの提案
- Author(s)
  池畑広伸
- Organizer
  第2回光皮膚科学研究会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] 生体皮膚における紫外線ゲノム毒性に対する応答
- Author(s)
  池畑広伸
- Organizer
  日本放射線影響学会第55回大会
- Place of Presentation
  仙台市
- Invited
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] M期の凝縮した染色体におけるDNA二本鎖切断の修復とその影響
- Author(s)
  小村潤一郎、池畑広伸、小野哲也
- Organizer
  日本放射線影響学会第55回大会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-23651044
[Presentation] 皮膚における紫外線に対する変異誘発抑制応答と紅斑反応の関連
- Author(s)
  池畑広伸、東正一、亀井保博
- Organizer
  第34回日本光医学･光生物学会
- Place of Presentation
  神戸市ポートアイランド
- Data Source
  KAKENHI-PROJECT-23651044

1. ONO Tetsuya (00107509)

# of Collaborated Projects: 13 results

# of Collaborated Products: 1 results
2. HOSOI Yoshio (50238747)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. KOMURA Junichiro (10215410)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. MORI Toshio (10115280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. KURISHITA Akihiro (60201472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YAMADA Shyogo (60158194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. UEHARA Yoshihiko (30223499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAMURA Nori (00010116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MORITA Masanobu (10519094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. YAMAMOTO Masayuki (50166823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. 鈴木隆史 (70508308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. AIBA Setsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KAMEI Yasuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. HIGASHI Shoichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 横井雅幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 花岡文雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ikehata Hironobu 池畑 広伸

IKEHATA Hironobu 池畑 広伸

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Analysis of the basic mechanism of tissue damage and mutation accumulation in UVR-exposed skinPrincipal Investigator

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Estimation of UV toxicity for the genome of skin with defective melanin synthesis and the elucidation of its mechanismPrincipal Investigator

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Mecahistic analysis of a protective response of skin tissue to UV genotoxicityPrincipal Investigator

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Analysis of the mechanism of tissue-specific protection of skin against the genotoxicity of ultraviolet radiationPrincipal Investigator

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Demonstration of the formation of cyclobutane pyrimidine dimers through the excited triplet state mediated by solar UV radiationPrincipal Investigator

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Analysis of the mechanism of a defensive response newly found in skin epidermis to the mutagenic effect of UV.Principal Investigator

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Action spectrum of UV-induced mutation in skinPrincipal Investigator

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Analysis of mutation induced in UV-irradiated skinPrincipal Investigator

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Ikehata Hironobu 池畑広伸

IKEHATA Hironobu 池畑広伸