Hoshino Tyuji 星野忠次

… Alternative Names

HOSHINO Tyuji 星野忠次

星野忠治ホシノチュウジ

HOSHINO Tadatsugu 星野忠次

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Researcher Number	90257220
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院薬学研究院, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2025: 千葉大学, 大学院薬学研究院, 准教授 2016: 千葉大学, 薬学研究院, 准教授 2012 – 2015: 千葉大学, 薬学研究科(研究院), 准教授 2013: 千葉大学, 薬学研究院, 准教授 2007 – 2011: Chiba University, 大学院・薬学研究院, 准教授 … More 2008: 千葉大学, 大学院・医学研究院, 准教授 1996 – 2000: Chiba Univ.Faculty of Pharmaceutical Sciences, Lecturer, 薬学部, 講師 1994 – 1995: 早稲田大学, 理工学部, 助手 Less
Review Section/Research Field	Principal Investigator Virology / Basic Section 49060:Virology-related / Basic Section 49050:Bacteriology-related / Transformative Research Areas, Section (II) / Bacteriology (including mycology) / 表面界面物性 / Physical pharmacy Except Principal Investigator Laboratory medicine / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related … More / Basic Section 28040:Nanobioscience-related / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 49010:Pathological biochemistry-related / Basic Section 47060:Clinical pharmacy-related / Basic Section 51030:Pathophysiologic neuroscience-related / Nanobioscience / Bacteriology (including mycology) / Physics / Bacteriology (including Mycology) / General surgery / Living organism molecular science Less
Keywords	Principal Investigator 有機合成 / 薬物設計 / X線結晶構造解析 / 阻害剤 / 計算機薬物設計 / 結晶構造解析 / 抗ウイルス薬 / 医薬品設計 / 計算機解析 / エンドヌクレアーゼ活性 … More / ポリメラーゼ / インフルエンザ / 薬物スクリーニング / 合成経路 / シミュレーション / プロテアーゼ阻害剤 / 分子動力学計算 / 薬剤耐性 / 変異体ウイルス / タンパク質 / 画像処理 / 記述子 / 機械学習 / 医薬抗体 / パターン認識 / 分子間相互作用 / ウイルスプロテアーゼ / 新型コロナウイルス感染症 / プロテアーゼ / 阻害活性 / 薬物有機合成 / Ｘ線結晶構造解析 / 計算機スクリーニング / 阻害活性測定 / X線共結晶構造解析 / 化合物合成 / インフルエンザウイルス / 阻害薬物 / 構造活性相関 / 酵素活性阻害 / 理論薬物設計 / メタロβ-ラクタマーゼ / 薬剤耐性菌 / 阻害化合物 / ヘマグルチニン / 活性測定 / ウイルス / 共結晶構造解析 / 結合構造 / 抗ウイルス活性 / スクリーニング / 共結晶解析 / 計算機シミュレーション / 阻害剤開発 / 分子 / 積相欠陥形成 / 半導体シリコン / 応力 / 原子拡散 / 活性化エネルギー / 動的過程 / 表面歪み / 理論計算 / 構造相転移 / シリコン結晶 / アスパラギン酸 / 結晶構造 / フラップ領域 / 特異的基質切断部位 / 水素結合 / ES複合体 / 水分子 / 量子化学計算 / 分子動力学法 / 活性部位 / HIV-1プロテアーゼ … More Except Principal Investigator FIR/PUF60 / リボソーム / rRNA / mRNA / １分子計測 / NVセンター / ダイヤモンド / スプライシング変異 / がん診断 / がん治療 / バイオマーカー / 動物モデル / 自己抗体 / FIB / スプライシング / 質量分析 / タンパク質 / 薬剤耐性 / X線結晶解析 / β-ラクタマーゼ / 構造生物学 / 蛋白質 / 抗生物質 / 感染症 / 癌化機構 / 転写 / ribosomal RNA / RNA polymerase II / 核小体 / ドミナントネガティブ / c-Myc / 抗体医薬品 / 臨床検査 / 悪性腫瘍 / 分子標的マーカー / 抗がん剤開発 / 新規動態解析 / mTORシグナリング経路 / 単一NVセンター / 量子計測 / ＮＶセンター / アミロイドβ / アルツハイマー病 / 転写後調節 / ヒストンアセチル化 / TFIIH p62 subunit / リボソーマルRNA / TFIIH / RNA-Seq / FIR / 疾患バイオマーカー候補 / 網羅的ゲノム解析 / 希少疾患 / 癌 / NGS / 発現亢進 / がん / 過敏症 / 薬物過敏症 / HLA / 自己免疫 / 抗体 / FACS / SEREX法 / SEREX / フローサイトメトリー / 神経免疫疾患 / 視神経脊髄炎 / 一分子計測 / ダイヤモンド中ＮＶセンタ / 創薬スクリーニング / ナノＮＭＲ / NVセンタ / ＮＭＲ / ＮＶセンタ / 1分子計測 / ダイヤモンドNVセンタ / 創薬応用 / ナノNMR / 早期がんの診断 / 発がんメカニズム / Wntシグナル / マウスモデル / 非ウイルス性慢性炎症 / スプライシング変異体 / イムノアッセイ / EIA / AlphaLisa / 消化器癌 / ドットブロット / ECLIA法 / FIRΔexon2 / 発癌動物モデル / 慢性炎症刺激 / 発がん / 慢性炎症 / がんバイオマーカー / 分子動力学計算 / β-ラクタム剤 / surface structural phase transition / ultrafine structure / positron annihilation / material control / point defect / Single Ion Implantation / Single Ion / 物性制御 / 表面構造相転移 / 極微構造 / 陽電子消滅 / 物質制御 / 点欠陥 / シングルイオン注入 / シングルイオン / 機能解析 / ノックアウトマウス / 臓器浸潤 / ｃ-ｍｙｃ遺伝子 / Ｔ細胞性急性リンパ性白血病 / 転写因子 / 急性Tリンパ性白血病 / c-myc / 癌糖代謝 / 急性リンパ性白血病 / PUF60/FIR / PKM2 / ｃ－ｍｙｃ / モデルマウス / T細胞性急性リンパ性白血病 / 酵素 / アポトーシス / 転写制御因子 / SF3b155 / スプライシング阻害薬 / 癌治療 / 癌診断 / c-myc遺伝子 / 癌遺伝子治療 / NMDA受容体 / インドール / 認知症 / 脳機能 / オピオイド / リコポジウム / 全合成 / 構造活性相関 / 不斉全合成 / 成分探索 / アルカロイド / 脳機能改善薬 / 鎮痛薬 Less

メタロ-β-ラクタマーゼを標的とした新規阻害薬物の創出Principal Investigator
- Principal Investigator
  
  星野忠次
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Chiba University
画像認識による分子間相互作用の解析と高機能性分子の設計作成Principal Investigator
- Principal Investigator
  
  星野忠次
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Chiba University
mTORシグナリング経路の新規動態解析と関連する抗がん剤開発
- Principal Investigator
  
  小林崇平
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  International University of Health and Welfare
核小体内におけるRNA polymerase IIによるribosomal RNAの転写と癌化機構の解明
- Principal Investigator
  
  松下一之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba University
単一ＮＶセンター配列を用いたタンパク質の１分子量子計測
- Principal Investigator
  
  谷井孝至
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  Waseda University
Development of inhibitors targeting enzymatic activity of SARS-CoV-2 proteasesPrincipal Investigator
- Principal Investigator
  
  Tyuji Hoshino
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Chiba University
In-cell分光法によるアミロイドβ産生制御機構・構造変化の解明と創薬
- Principal Investigator
  
  松崎勝巳
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kyoto University
Expression analysis of ribosome constituent proteins in cancer cells and their involvement in post-transcriptional regulation
- Principal Investigator
  
  Matsushita Kazuyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Chiba University
Development of an evaluation system for skin-specific hypersensitivity risk compounds based on structural characteristics of HLA polymorphisms
- Principal Investigator
  
  Ito Kousei
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Chiba University
Development of Inhibitors for Influenza Endonuclease ActivityPrincipal Investigator
- Principal Investigator
  
  Hoshino Tyuji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Chiba University
Comprehensive search of autoantibies in neuroimmunological disorders using a novel hybrid SEREX-FACS method
- Principal Investigator
  
  Masahiro Mori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Chiba University
Establishment of detection methods of early cancers with chronic inflammation by non-viral mechanism
- Principal Investigator
  
  Matsushita Kazuyuki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Chiba University
Developing a novel method of optically detected magnetic resonance measurement method for pharmaceutical application
- Principal Investigator
  
  Tanii Takashi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nanobioscience
- Research Institution
  Waseda University
Development of Inhibitors for Metallo-beta-lactamasesPrincipal Investigator
- Principal Investigator
  
  Hoshino Tyuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Chiba University
Development of a novel mechanism of T-ALL and its clinical application for the diagnosis and treatment.
- Principal Investigator
  
  MATSUSHITA Kazuyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Chiba University
Structure basis of reaction mechanism of beta-lactamases and new inhibitor search
- Principal Investigator
  
  Nukaga Michiyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Josai International University
Develpoment of inhibitors for endo-nuclease activity of influenza virusesPrincipal Investigator
- Principal Investigator
  
  HOSHINO Tyuji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Chiba University
Ultra high resolution Xray crystallographic study for antibiotic mechanisms of action and resistance
- Principal Investigator
  
  NUKAGA Michiyoshi
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Josai International University
Development of anti-HIV agents for the viral variantsPrincipal Investigator
- Principal Investigator
  
  HOSHINO Tyuji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Chiba University
Development of novel cancer diagnosis and treatment targeting splicing variants of c-myc transcriptional suppressor FIR
- Principal Investigator
  
  MATSUSHITA Kazuyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Chiba University
Search, asymmetric synthesis, and medicinal chemistry study on the plant alkaloids that regulate the brain nervous system.
- Principal Investigator
  
  TAKAYAMA Hiromitsu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Chiba University
Development of anti-HIV chemicals effective for the virus conferring drug resistancePrincipal Investigator
- Principal Investigator
  
  HOSHINO Tyuji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Chiba University
半導体固体表面の構造相転移に対する応力の影響の理論的解析Principal Investigator
- Principal Investigator
  
  星野忠次
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  表面界面物性
- Research Institution
  Chiba University
HIV-1プロテアーゼの作用機構の解明Principal Investigator
- Principal Investigator
  
  星野忠次
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Doping by single Ion Implantation and its application to solid state materials and devices.
- Principal Investigator
  
  OHDOMARI Iwao
- Project Period (FY)
  1993 – 1996
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Physics
- Research Institution
  Waeda University

[Journal Article] Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase2023
- Author(s)
  Ito Yuma、Lu Huiyan、Kitajima Mariko、Ishikawa Hayato、Nakata Yoshihiro、Iwatani Yasumasa、Hoshino Tyuji
- Journal Title
  
  Journal of Natural Products
  
  Volume: 86 Issue: 11 Pages: 2487-2495
- DOI
  10.1021/acs.jnatprod.3c00662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07050, KAKENHI-PROJECT-21H02608, KAKENHI-PROJECT-23K24144
[Journal Article] Combinational antibody detection approach increases the clinical validity of colorectal cancer screening2023
- Author(s)
  Kobayashi Sohei、Hiwasa Takaki、Kitamura Kouichi、Kano Masayuki、Hoshino Tyuji、Hirano Sho、Hashimoto Mayuko、Seimiya Masanori、Shimada Hideaki、Nomura Fumio、Matsubara Hisahiro、Matsushita Kazuyuki
- Journal Title
  
  Journal of Clinical Laboratory Analysis
  
  Volume: 37 Issue: 21-22 Pages: 1-11
- DOI
  10.1002/jcla.24978
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07858, KAKENHI-PROJECT-21K08695, KAKENHI-PROJECT-22K08747, KAKENHI-PROJECT-23K06618, KAKENHI-PROJECT-23K06712, KAKENHI-PROJECT-20K07336
[Journal Article] <i>In Silico</i> Identification of Inhibitory Compounds for SARS-Cov-2 Papain-Like Protease2023
- Author(s)
  Miwa Kazunori、Guo Yan、Hata Masayuki、Hirano Yoshinori、Yamamoto Norio、Hoshino Tyuji
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 71 Issue: 12 Pages: 897-905
- DOI
  10.1248/cpb.c23-00622
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2023-12-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-21K07050
[Journal Article] Computational Screening of Inhibitory Compounds for SARS-Cov-2 3CL Protease with a Database Consisting of Approved and Investigational Chemicals2023
- Author(s)
  Miwa Kazunori、Guo Yan、Hata Masayuki、Yamamoto Norio、Hoshino Tyuji
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 71 Issue: 5 Pages: 360-367
- DOI
  10.1248/cpb.c23-00035
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2023-05-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-21K07050
[Journal Article] The Link of mRNA and rRNA Transcription by PUF60/FIR through TFIIH/P62 as a Novel Therapeutic Target for Cancer2023
- Author(s)
  Kitamura Kouichi、Hoshino Tyuji、Okabe Atsushi、Fukuyo Masaki、Rahmutulla Bahityar、Tanaka Nobuko、Kobayashi Sohei、Tanaka Tomoaki、Shida Takashi、Ueda Mashiro、Minamoto Toshinari、Matsubara Hisahiro、Kaneda Atsushi、Ishii Hideshi、Matsushita Kazuyuki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 24 Pages: 17341-17341
- DOI
  10.3390/ijms242417341
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K17429, KAKENHI-PROJECT-21K15599, KAKENHI-PROJECT-19KK0415, KAKENHI-PROJECT-22K07164, KAKENHI-PROJECT-23K06618, KAKENHI-PROJECT-23K06712, KAKENHI-PROJECT-20K07336, KAKENHI-PROJECT-21K19526, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H00541, KAKENHI-PROJECT-23K23859
[Journal Article] Weak complex formation of adverse drug reaction-associated HLA B57, B58, and B15 molecules2022
- Author(s)
  Shirayanagi Tomohiro、Kazaoka Akira、Watanabe Kenji、Qu Liang、Sakamoto Naoki、Hoshino Tyuji、Ito Kousei、Aoki Shigeki
- Journal Title
  
  Toxicology in Vitro
  
  Volume: 82 Pages: 105383-105383
- DOI
  10.1016/j.tiv.2022.105383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03386, KAKENHI-PROJECT-23K21366
[Journal Article] Computational and Crystallographic Analysis of Binding Structures of Inhibitory Compounds for HIV-1 RNase H Activity2022
- Author(s)
  Lu Huiyan、Komukai Yuji、Usami Koto、Guo Yan、Qiao Xinyue、Nukaga Michiyoshi、Hoshino Tyuji
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 62 Issue: 24 Pages: 6762-6774
- DOI
  10.1021/acs.jcim.2c00537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07050
[Journal Article] Influence of Glycan Agents on Protein Crystallization with Ammonium Sulfate2022
- Author(s)
  Guo Yan、Hoshino Tyuji
- Journal Title
  
  Crystal Growth & Design
  
  Volume: 22 Issue: 11 Pages: 6751-6765
- DOI
  10.1021/acs.cgd.2c00901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07050
[Journal Article] Anti-FIRΔexon2 autoantibody as a novel indicator for better overall survival in gastric cancer2021
- Author(s)
  Kobayashi S, Hiwasa T, Ishige T, Kano M, Hoshino T, Rahmutulla B, Seimiya M, Shimada H, Nomura F, Matsubara H, Matsushita K.
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 2 Pages: 847-858
- DOI
  10.1111/cas.14767
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07336, KAKENHI-PROJECT-20K07858, KAKENHI-PROJECT-20K16436, KAKENHI-PROJECT-20H03749, KAKENHI-PROJECT-17K09004, KAKENHI-PROJECT-20K16513
[Journal Article] Analysis of Binding Modes of Antigen-Antibody Complexes by Molecular Mechanics Calculation2021
- Author(s)
  Qu, L., Qiao, X., Qi, F., Nishida, N., Hoshino, T.
- Journal Title
  
  J. Chem. Inform. Model.
  
  Volume: 61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07138
[Journal Article] Secondary Structure and Conformational Stability of the Antigen Residues Making Contact with Antibodies2021
- Author(s)
  Qiao Xinyue、Qu Liang、Guo Yan、Hoshino Tyuji
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 125 Issue: 41 Pages: 11374-11385
- DOI
  10.1021/acs.jpcb.1c05997
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07050
[Journal Article] Identification of the Inhibitory Compounds for Metallo-β-lactamases and Structural Analysis of the Binding Modes2021
- Author(s)
  Kamo T, Kuroda K, Kondo S, Hayashi U, Fudo S, Yoneda T, Takaya A, Nukaga M, Hoshino T.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 69 Issue: 12 Pages: 1179-1183
- DOI
  10.1248/cpb.c21-00611
- NAID
  130008123292
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2021-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07484, KAKENHI-PROJECT-21K07050
[Journal Article] Quantifying the Separation of Positive and Negative Areas in Electrostatic Potential for Predicting Feasibility of Ammonium Sulfate for Protein Crystallization2021
- Author(s)
  Guo Yan、Nishida Noritaka、Hoshino Tyuji
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 61 Issue: 9 Pages: 4571-4581
- DOI
  10.1021/acs.jcim.1c00505
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04693, KAKENHI-PLANNED-21H05250, KAKENHI-PROJECT-21K07050
[Journal Article] Analysis of Binding Modes of Antigen-Antibody Complexes by Molecular Mechanics Calculation2021
- Author(s)
  Qu Liang、Qiao Xinyue、Qi Fei、Nishida Noritaka、Hoshino Tyuji
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 61 Issue: 5 Pages: 2396-2406
- DOI
  10.1021/acs.jcim.1c00167
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04693, KAKENHI-PLANNED-21H05250, KAKENHI-PROJECT-21K07050
[Journal Article] Detection of Abacavir-Induced Structural Alterations in Human Leukocyte Antigen-B*57 : 01 Using Phage Display2020
- Author(s)
  Shirayanagi Tomohiro、Aoki Shigeki、Fujimori Sota、Watanabe Kenji、Aida Tetsuo、Hirasawa Makoto、Kumagai Kazuyoshi、Hoshino Tyuji、Ito Kousei
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 6 Pages: 1007-1015
- DOI
  10.1248/bpb.b20-00102
- NAID
  130007850243
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-06-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03386
[Journal Article] Electrostatic Potentials around the Proteins Preferably Crystallized by Ammonium Sulfate2020
- Author(s)
  Guo Yan、Qu Liang、Nishida Noritaka、Hoshino Tyuji
- Journal Title
  
  Crystal Growth & Design
  
  Volume: 21 Issue: 1 Pages: 297-305
- DOI
  10.1021/acs.cgd.0c01136
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04693, KAKENHI-PROJECT-18K07138
[Journal Article] Post-transcriptional regulation of BRG1 by FIRΔexon2 in gastric cancer2020
- Author(s)
  Ailiken Guzhanuer、Kitamura Kouichi、Hoshino Tyuji、Satoh Mamoru、Tanaka Nobuko、Minamoto Toshinari、Rahmutulla Bahityar、Kobayashi Sohei、Kano Masayuki、Tanaka Tomoaki、Kaneda Atsushi、Nomura Fumio、Matsubara Hisahiro、Matsushita Kazuyuki
- Journal Title
  
  Oncogenesis
  
  Volume: 9 Issue: 2 Pages: 26-26
- DOI
  10.1038/s41389-020-0205-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KT0019, KAKENHI-PROJECT-19H03726, KAKENHI-PROJECT-19H03727, KAKENHI-PROJECT-17KT0124, KAKENHI-PROJECT-18K07462, KAKENHI-PROJECT-20K07336, KAKENHI-PROJECT-20K16436, KAKENHI-PROJECT-19H03708, KAKENHI-PROJECT-17K09004, KAKENHI-PROJECT-18K19577
[Journal Article] Anti-FIRΔexon2, a splicing variant form of PUF60, auto-antibody is detected in the sera of esophageal squamous cell carcinoma.2019
- Author(s)
  Kobayashi S, Hiwasa T, Ishige T, Rahmutulla B, Kano M, Hoshino T, Minamoto T, Shimada H, Nomura F, Matsubara H, Matsushita K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 4 Issue: 6 Pages: 1-10
- DOI
  10.1111/cas.14024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09004, KAKENHI-PROJECT-16K10520, KAKENHI-PROJECT-19H03727, KAKENHI-PROJECT-17KT0124, KAKENHI-PROJECT-17K15768, KAKENHI-PROJECT-18K19577
[Journal Article] Anisotropic Distribution of Ammonium Sulfate Ions in Protein Crystallization2019
- Author(s)
  Kitahara Mariko、Fudo Satoshi、Yoneda Tomoki、Nukaga Michiyoshi、Hoshino Tyuji
- Journal Title
  
  Crystal Growth & Design
  
  Volume: 19 Issue: 11 Pages: 6004-6010
- DOI
  10.1021/acs.cgd.9b00256
- Data Source
  KAKENHI-PROJECT-18K07138
[Journal Article] Computational Study on the Assembly of Amyloid β-Peptides in the Hydrophobic Environment2019
- Author(s)
  Qu Liang、Fudo Satoshi、Matsuzaki Katsumi、Hoshino Tyuji
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 9 Pages: 959-965
- DOI
  10.1248/cpb.c19-00171
- NAID
  130007699659
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-09-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-18K07138
[Journal Article] Simulation Study on Complex Conformations of Aβ<sub>42</sub> Peptides on a GM1 Ganglioside-Containing Lipid Membrane2018
- Author(s)
  Vahed Majid、Neya Saburo、Matsuzaki Katsumi、Hoshino Tyuji
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66 Issue: 2 Pages: 170-177
- DOI
  10.1248/cpb.c17-00740
- NAID
  130006328084
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08458
[Journal Article] Analysis of Physicochemical Interaction of Aβ40 with GM1 Ganglioside-Containing Lipid Membrane2018
- Author(s)
  Vahed Majid、Neya Saburo、Matsuzaki Katsumi、Hoshino Tyuji
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: 122 Issue: 14 Pages: 3771-3781
- DOI
  10.1021/acs.jpcb.8b00139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08458
[Journal Article] Disturbed alternative splicing of FIR (PUF60) directed cyclin E overexpression in esophageal cancers2018
- Author(s)
  Ogura Yukiko、Hoshino Tyuji、Tanaka Nobuko、Ailiken Guzhanuer、Kobayashi Sohei、Kitamura Kouichi、Rahmutulla Bahityar、Kano Masayuki、Murakami Kentarou、Akutsu Yasunori、Nomura Fumio、Itoga Sakae、Matsubara Hisahiro、Matsushita Kazuyuki
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 33 Pages: 22929-22944
- DOI
  10.18632/oncotarget.25149
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09004, KAKENHI-PROJECT-17KT0124
[Journal Article] Simulation Time Required for Diminishing the Initial Conformational Deviations among Protein Crystal Structures2018
- Author(s)
  Qi Fei、Yoneda Tomoki、Neya Saburo、Hoshino Tyuji
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 122 Issue: 36 Pages: 8503-8515
- DOI
  10.1021/acs.jpcb.8b04800
- Data Source
  KAKENHI-PROJECT-18K07138
[Journal Article] Prediction of Ligand Binding Affinity to Target Proteins by Molecular Mechanics Theoretical Calculation2017
- Author(s)
  Hideyoshi Fuji, Fei Qi, Liang Qu, Yoshihisa Takaesu, Tyuji Hoshino
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 65 Issue: 5 Pages: 461-468
- DOI
  10.1248/cpb.c16-00913
- NAID
  130005631517
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08458
[Journal Article] Influence of precipitants on molecular arrangement and space group of protein crystals2017
- Author(s)
  S. Fudo, F. Qi, M. Nukaga, T. Hoshino
- Journal Title
  
  Cryst. Growth Des.
  
  Volume: 17 Issue: 2 Pages: 534-542
- DOI
  10.1021/acs.cgd.6b01385
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08458
[Journal Article] Enhancement of the stability of single chain Fv molecules with the amino acid substitutions predicted by high-performance computer2016
- Author(s)
  T. Hoshino, K. Matsuo, J. Komano, F. Maeda, M. Takekoshi
- Journal Title
  
  Asia Pacific Biotech News
  
  Volume: 20 Pages: 32-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08458
[Journal Article] Anti-FIRs (PUF60) auto-antibodies are detected in the sera of early-stage colon cancer patients.2016
- Author(s)
  Kobayashi S, Hoshino T, Hiwasa T, Satoh M, Rahmutulla B, Tsuchida S, Komukai Y, Tanaka T, Matsubara H, Shimada H, Nomura F, Matsushita K
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 50 Pages: 82493-82503
- DOI
  10.18632/oncotarget.12696
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460505, KAKENHI-PROJECT-26460667, KAKENHI-PROJECT-15K08610, KAKENHI-PROJECT-15K11379
[Journal Article] Two distinctive binding modes of endonuclease inhibitors to the N-terminal region of influenza virus polymerase acidic subunit2016
- Author(s)
  S. Fudo, N. Yamamoto, M. Nukaga, T. Odagiri, M. Tashiro, T. Hoshino
- Journal Title
  
  Biochemistry
  
  Volume: 55 Issue: 18 Pages: 2646-2660
- DOI
  10.1021/acs.biochem.5b01087
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08458
[Journal Article] Roles of the respective loops at complementarity determining region on the antigen-antibody recognition2016
- Author(s)
  T. Osajima, T. Hoshino
- Journal Title
  
  Computational Biology and Chemistry
  
  Volume: 64 Pages: 368-383
- DOI
  10.1016/j.compbiolchem.2016.08.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08458
[Journal Article] Structural and computational study on inhibitory compounds for endonuclease activity of influenza virus polymerase2015
- Author(s)
  S. Fudo, N. Yamamoto, M. Nukaga, T. Odagiri, M. Tashiro, S. Neya, T. Hoshino
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 Issue: 17 Pages: 5466-5475
- DOI
  10.1016/j.bmc.2015.07.046
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08458
[Journal Article] Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53- dependent T-cell acute lymphoblastic leukemia progression by activating Notch1.2015
- Author(s)
  Matsushita K, Kitamura K, Rahmutulla B,, Tanaka N, Ishige T, Satoh M, Hoshino T, Miyagi S, Mori T, Itoga S, Shimada H, Tomonaga T, Kito M, Nakajima-Takagi Y, Kubo S, Nakaseko C, Hatano M, Miki T, Matsuo M, Fukuyo M, Kaneda A, Iwama A and Nomura F.
- Journal Title
  
  Oncotarget.
  
  Volume: 6 Pages: 5102-17
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460667
[Journal Article] A Dominant Factor for Structural Classification of Protein Crystals2015
- Author(s)
  F. Qi, S. Fudo, S. Neya, T. Hoshino
- Journal Title
  
  J. Chem. Inform. Model.
  
  Volume: 55 Issue: 8 Pages: 1673-1685
- DOI
  10.1021/acs.jcim.5b00052
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08458
[Journal Article] Computational and statistical study on the molecular interaction between antigen and antibody2014
- Author(s)
  T. Osajima, M. Suzuki, S. Neya, T. Hoshino
- Journal Title
  
  J. Mol. Graphics Model.
  
  Volume: 53 Pages: 128-139
- DOI
  10.1016/j.jmgm.2014.07.005
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590548, KAKENHI-PROJECT-24750034
[Journal Article] A cluster analysis on the structural diversity of protein crystals, exemplified by human immunodeficiency virus type 1 protease2014
- Author(s)
  F. Qi, S. Fudo, S. Neya, T. Hoshino
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590548
[Journal Article] A Cluster Analysis on the Structural Diversity of Protein Crystals, Exemplified by Human Immunodeficiency Virus Type 1 Protease2014
- Author(s)
  F. Qi, S. Fudo, S. Neya, T. Hoshino
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 62 Issue: 6 Pages: 568-577
- DOI
  10.1248/cpb.c14-00095
- NAID
  130004137270
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590548
[Journal Article] Binding and Aggregation Mechanism of Amyloid β-Peptides Onto the GM1 Ganglioside-Containing Lipid Membrane2013
- Author(s)
  T. Hoshino, Md. I. Mahmood, K. Mori, K. Matsuzaki
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: 117 Issue: 27 Pages: 8085-8094
- DOI
  10.1021/jp4029062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590548
[Journal Article] Structural Modulation Study of Inhibitory Compounds for RNase H Activity of HIV-1 Reverse Transcriptase2012
- Author(s)
  H. Yanagita, S. Fudo, E. Urano, R. Ichikawa, M. Ogata, M. Yokota, T. Murakami, H. Wu, J. Chiba, J. Komano, T. Hoshino
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60 Pages: 764-771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590548
[Journal Article] Formation of GM1 Ganglioside Clusters on the Lipid Membrane Containing Sphingomyeline and Cholesterol2012
- Author(s)
  K. Mori, M. I. Mahmood, S. Neya, K. Matsuzaki, T. Hoshino
- Journal Title
  
  Journal of Physical Chemistry B
  
  Volume: 116 Issue: 17 Pages: 5111-5121
- DOI
  10.1021/jp207881k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590548
[Journal Article] Mechanism of drug resistance of hemagglutinin of influenza virus and potent scaffolds inhibiting its function2012
- Author(s)
  H. Yanagita, N. Yamamoto, H. Fuji, X. Liu, M. Ogata, M. Yokota, H. Takaku, H. Hasegawa, T. Odagiri, M. Tashiro, T. Hoshino
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 7 Issue: 3 Pages: 552-562
- DOI
  10.1021/cb200332k
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590548
[Journal Article] Structural Modulation Study of Inhibitory Compounds for RNase H Activity of HIV-1 Reverse Transcriptase2012
- Author(s)
  H.Yanagita, S.Fudo, E.Urano, R.Ichikawa, M.Ogata, M.Yokota, T.Murakami, H.Wu, J.Chiba, J.Komano, T.Hoshino
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590506
[Journal Article] Structural Modulation Study of Inhibitory Compounds for RN ase H Activity of HIV-1 Reverse Transcriptase2012
- Author(s)
  H. Yanagita, S. Fudo, E. Urano, R. Ichikawa, M. Ogata, M. Yokota, T. Murakami, H. Wu, J. Chiba, J. Komano, T. Hoshino
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 60巻(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590506
[Journal Article] Structural and Biochemical Study on the Inhibitory Activity of Derivatives of5-nitro-furan-2-carboxylic acid for RNase H Function of HIV-1 Reverse Transcriptase2011
- Author(s)
  H. Yanagita, E. Urano, K. Matsumoto, R. Ichikawa, Y. Takaesu, M. Ogata, T. Murakami, H. G. Wu, J. Chiba, J. Komano, T. Hoshino
- Journal Title
  
  Bioorganic Medicinal Chemistry
  
  Volume: 19巻 Pages: 816-825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590506
[Journal Article] Structural and Biochemical Study on the Inhibitory Activity of Derivatives of 5-nitro-furan-2-carboxylic acid for RNase H Function of HIV -1 Reverse Transcriptase2011
- Author(s)
  H.Yanagita, E.Urano, K.Matsumoto, R.Ichikawa, Y.Takaesu, M.Ogata, T.Murakami, H.G.Wu, J.Chiba, J.Komano, T.Hoshino
- Journal Title
  
  Bioorganic Medical Chemistry
  
  Volume: 19 Pages: 816-825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590506
[Journal Article] CHAP31 Induces Apoptosis Only via the Intrinsic Pathway in Human Esophageal Cancer Cells.2010
- Author(s)
  Murakami K, Matsubara H, Hoshino I, Akutsu Y, Miyazawa Y, Matsushita K, Sakata H, Nishimori T, Usui A, Kano M, Nishino N, Yoshida M.
- Journal Title
  
  Oncology. 78(1)
  
  Pages: 62-74
- Data Source
  KAKENHI-PROJECT-20591543
[Journal Article] CHAP31 Induces Apoptosis Only via the Intrin sicPathway in Human Esophageal Cancer Cells.2010
- Author(s)
  Murakami K, Matsubara H, Hoshino I, Akutsu Y, Miyazawa Y, Matsushita K, Sakata H, Nishimori T, Usui A, Kano M, Nishino N, Yoshida M.
- Journal Title
  
  Oncology. 78(1)
  
  Pages: 62-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591543
[Journal Article] Structural and Energetic Analysis onthe Complexes of Clinically-isolated Subtype C HIV-1 Proteases and Approved Inhibitors by Molecular Dynamics Simulation2010
- Author(s)
  S. Matsuyama, A. Aydan, H. Ode, M. Hata, W. Sugiura, T. Hoshino
- Journal Title
  
  Journal of Physical Chemistry B
  
  Volume: 114巻 Pages: 521-530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590506
[Journal Article] Structural and Energetic Analysis on the Complexes of Clinically-isolated Subtype C HIV-1 Proteases and Approved Inhibitors by Molecular Dynamics Simulation2010
- Author(s)
  S.Matsuyama, A.Aydan, H.Ode, M.Hata, W.Sugiura, T.Hoshino
- Journal Title
  
  Journal of Physical Chemistry B 114
  
  Pages: 521-530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590506
[Journal Article] Role of histone deacetylase inhibitor in adenovirus-mediated p53 gene therapy in esophageal cancer.2008
- Author(s)
  Hoshino I, Matsubara H, Akutsu Y, Nishimori T, Yoneyama Y, Murakami K, Sakata H, Matsushita K, Komatsu A, Brooks R, Ochiai T
- Journal Title
  
  Anticancer Res. 28(2A)
  
  Pages: 665-671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591543
[Journal Article] Development of Software Program Predicting the Binding Site and the Binding Mode of Ligands Against a Target Protein2008
- Author(s)
  H. Fuji, M. Suzuki, S. Neya, T. Hoshino
- Journal Title
  
  e-Journal of Surface Science and Nanotechnology 6
  
  Pages: 241-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590467
[Journal Article] Combined Effects of p53 Gene Therapy and Leptomycin B in Human Esophageal Squamous Cell Carcinoma.2008
- Author(s)
  Hoshino I, Matsubara H, Komatsu A, Akutsu Y, Nishimori T, Yoneyama Y, Murakami k, Sakata H, Matsushita K, Miyazawa Y, Brooks R, Yoshida M, Ochiai T.
- Journal Title
  
  Oncology. 75(1-2)
  
  Pages: 113-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591543
[Journal Article] Mechanism of Drug Resistance Due to N88S in CRF01_AE HIV-1 Protease Analyzed by Molecular Dynamics Simulations2007
- Author(s)
  H. Ode, S. Matsuyama, M. Hata, T. Hoshino, J. Kakizawa, W. Sugiura
- Journal Title
  
  Journal of Medicinal Chemistry 50
  
  Pages: 1768-1777
- NAID
  120007075525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590467
[Journal Article] HIVプロテアーゼ阻害剤とウイルスの薬剤耐性、分子構造から考える薬物の作用機序(11)2007
- Author(s)
  星野忠次, 大出裕高
- Journal Title
  
  医薬ジャーナル 43
  
  Pages: 5-11
- Data Source
  KAKENHI-PROJECT-19590467
[Journal Article] Computational Characterization of Structural Role of the Non- active Site Mutation M36I of Human Immunodeficiency Virus Type 1 Protease2007
- Author(s)
  H. Ode, S. Matsuyama, M. Hata, S. Neya, J. Kakizawa, W. Sugiura, T. Hoshino
- Journal Title
  
  Journal of Molecular Biology 370
  
  Pages: 598-607
- NAID
  120007075168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590467
[Journal Article] Computational Characterization of Structural Role of the Non-active Site Mutation M36I of Human Immunodeficiency Virus Type 1 Protease2007
- Author(s)
  H. Ode, S. Matsuyama, M. Hata, S. Neya, J, Kakizawa, W. Sugiura, T. Hoshino
- Journal Title
  
  Journal of Molecular Biology 370
  
  Pages: 598-607
- NAID
  120007075168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590467
[Patent] 芳香環含有化合物並びに癌の予防剤および／または治療剤2017
- Inventor(s)
  松下一之、星野忠治他
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-110822
- Filing Date
  2017
- Acquisition Date
  2018
- Data Source
  KAKENHI-PROJECT-17K09004
[Presentation] ドッキングシミュレーションと構造最適化計算を用いたSARS CoV-2 papain-like protease阻害薬の探索2024
- Author(s)
  三輪和範、郭艶、畑晶之、平野秀典、山本典生、星野忠次
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K07050
[Presentation] 生細胞膜中で形成されるアミロイドβタンパク質の構造解析2021
- Author(s)
  角友登、河野健一、矢野義明、星野大、松崎勝巳
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-23K21355
[Presentation] In silico structural analysis of HLA complexes associated with idiosyncratic drug toxicities2020
- Author(s)
  Tomohiro Shirayanagi, Kenji Watanabe, Shigeki Aoki, Takahiro Goto, Liang Qu, Tyuji Hoshino, Kousei Ito
- Organizer
  7th FIP Pharmaceutical Sciences World Congress (PSWC2020 Virtual)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03386
[Presentation] インフルエンザのエンドヌクレアーゼ活性を阻害する化合物の合成と結合構造解析2019
- Author(s)
  齋藤聡、米田友貴、額賀路嘉、山本典生、星野忠次
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K07138
[Presentation] Structural analysis of HLA stability associated with idiosyncratic drug toxicities2019
- Author(s)
  Tomohiro Shirayanagi, Kenji Watanabe, Shigeki Aoki, Takahiro Goto, Liang Qu, Tyuji Hoshino, Kousei Ito
- Organizer
  19th Symposium for Gene Design and Delivery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03386
[Presentation] タンパク質結晶の初期原子座標の差異性が除去されるのに必要な計算時間2018
- Author(s)
  斉非, 米田友貴, 根矢三郎, 星野忠次
- Organizer
  日本薬学会第13８年会
- Data Source
  KAKENHI-PROJECT-15K08458
[Presentation] タンパク質複合体の構造の予測方法の探索2018
- Author(s)
  瞿良, 米田友貴, 根矢三郎, 星野忠次
- Organizer
  日本薬学会第13８年会
- Data Source
  KAKENHI-PROJECT-15K08458
[Presentation] 金属原子を活性中心に持つウイルス酵素とその阻害剤開発2017
- Author(s)
  星野忠次
- Organizer
  生物無機化学夏季セミナー
- Data Source
  KAKENHI-PROJECT-15K08458
[Presentation] タンパク質構造の結晶依存性が消失するのに必要な分子動力学シミュレーションの計算時間2017
- Author(s)
  斉非, 米田友貴, 根矢三郎, 星野忠次
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際会議場
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08458
[Presentation] タンパク質複合体構造の計算予測2017
- Author(s)
  瞿良, 米田友貴, 根矢三郎, 星野忠次
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際会議場
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08458
[Presentation] 新規メタロ-β-ラクタマーゼ阻害剤における構造活性相関研究2016
- Author(s)
  近藤翔太、林初咲、不動聡志、額賀路嘉、米田友貴、根矢三郎、星野忠次
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08458
[Presentation] 計算機解析に基づくインフルエンザウイルス感染阻害薬物の開発2013
- Author(s)
  星野忠次
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー」地区ミニシンポジウム
- Place of Presentation
  千葉市、千葉大学薬学部
- Invited
- Data Source
  KAKENHI-PROJECT-24590548
[Presentation] ２価金属原子対を標的とした抗ウイルス薬の開発2013
- Author(s)
  星野忠次
- Organizer
  感染症研究グローバルネットワークフォーラム
- Place of Presentation
  千葉市、千葉大学薬学部
- Invited
- Data Source
  KAKENHI-PROJECT-24590548
[Presentation] V82A,I84V変異を標的としたHIV-1プロテアーゼ阻害薬の設計2010
- Author(s)
  藍檀愛, 萩原洋子, 鈴木優章, 根矢三郎, 星野忠次
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590506
[Presentation] V82A, I84V変異を標的としたHIV-1プロテアーゼ阻害薬の設計2010
- Author(s)
  藍檀愛, 萩原洋子, 鈴木優章, 根矢三郎, 星野忠次
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター(岡山県)
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590506
[Presentation] L90M変異を標的としたHIV-1プロテアーゼ阻害薬の薬物設計と合成2009
- Author(s)
  中里俊文, 高村斉, 清水愛, 大出裕高, 杉浦亙, 鈴木優章, 根矢三郎, 原田真至, 西田篤司, 星野忠次
- Organizer
  日本薬学会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19590467
[Presentation] c-myc遺伝子転写抑制因子FIRの癌特異的スプライシングバリアントを標的とした癌診断法および癌治療薬の開発2009
- Author(s)
  松下一之、梶原寿子、朝長毅、島田英昭、田村裕、星野忠治、野村文夫
- Organizer
  第27回日本分子腫瘍マーカー研究会
- Place of Presentation
  東京
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20591543
[Presentation] コンピューターによる薬剤耐性HIV-1に対する薬効予測の試み2008
- Author(s)
  星野忠次, 辰巳絢子, 篠原祐子, 大出裕高, 杉浦亙
- Organizer
  日本エイズ学会
- Place of Presentation
  大阪
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-19590467
[Presentation] L90M変異体に阻害作用をもつ抗HIV薬の設計・合成2007
- Author(s)
  中里俊文, 高村斉, 大出裕高, 清水愛, 杉浦亙, 星野忠次
- Organizer
  日本エイズ学会
- Place of Presentation
  広島
- Year and Date
  2007-11-28
- Data Source
  KAKENHI-PROJECT-19590467
[Presentation] 臨床検体由来SubtypeC HIV-1 proteaseの薬剤耐性機構に関する構造化2007
- Author(s)
  松山翔, 大出裕高, 柿澤淳子, 杉浦亙, 星野忠次
- Organizer
  日本エイズ学会
- Place of Presentation
  広島
- Year and Date
  2007-11-29
- Data Source
  KAKENHI-PROJECT-19590467
[Presentation] 臨床検体由来SubtypeC HIV-1 proteaseの薬剤耐性機構に関する構造化学的研究2007
- Author(s)
  松山翔, 大出裕高, 柿澤淳子, 杉浦亙, 星野忠次
- Organizer
  日本エイズ学会
- Place of Presentation
  広島
- Year and Date
  2007-11-29
- Data Source
  KAKENHI-PROJECT-19590467
[Presentation] インフルエンザウイルスエンドヌクレアーゼ活性部位とその阻害化合物の共結晶構造解析
- Author(s)
  不動聡志, 米谷陽子, 額賀路嘉, 山本典生, 鈴木優章, 根矢三郎, 星野忠次
- Organizer
  日本薬学会代135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590548
[Presentation] Alternative splicing rather than haploinsufficiency of c-myc transcriptional repressor, FIR, promotes P53-dependent T-cell lymphoblastic leukemia progression.
- Author(s)
  Matsushita K, Kitamura K, Bahityar R, Hoshino T, Iwama A, Shimada H, Tomonaga T, Kubo S, and Nomura F.
- Organizer
  The 73rd annual meeting of the Japanese cancer association
- Place of Presentation
  Yokohama・パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26460667
[Presentation] インフルエンザウイルスエンドヌクレアーゼ活性部位とその阻害化合物の共結晶構造解析
- Author(s)
  不動聡志, 米谷陽子, 額賀路嘉, 山本典生, 鈴木優章, 根矢三郎, 星野忠次
- Organizer
  スーパーコンピュータワークショップ2015
- Place of Presentation
  岡崎
- Year and Date
  2015-01-29 – 2015-01-30
- Data Source
  KAKENHI-PROJECT-24590548

1. MATSUSHITA Kazuyuki (90344994)

# of Collaborated Projects: 6 results

# of Collaborated Products: 12 results
2. 西村基 (80400969)

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33. BONOMO Robert

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35. Robert Bonomo

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37. SEIMIYA Masanori

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38. 佐藤守

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39. 松崎勝己

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40. 田中知明

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Hoshino Tyuji 星野 忠次

HOSHINO Tyuji 星野 忠次

星野 忠治 ホシノ チュウジ

HOSHINO Tadatsugu 星野 忠次

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メタロ-β-ラクタマーゼを標的とした新規阻害薬物の創出Principal Investigator

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画像認識による分子間相互作用の解析と高機能性分子の設計作成Principal Investigator

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Development of inhibitors targeting enzymatic activity of SARS-CoV-2 proteasesPrincipal Investigator

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Development of Inhibitors for Influenza Endonuclease ActivityPrincipal Investigator

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Development of Inhibitors for Metallo-beta-lactamasesPrincipal Investigator

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Hoshino Tyuji 星野忠次

HOSHINO Tyuji 星野忠次

星野忠治ホシノチュウジ

HOSHINO Tadatsugu 星野忠次