Kakehata Seiji 欠畑誠治

… Alternative Names

KAKEHATA Seiji 欠畑誠治

欠畑誠治カケハタセイジ

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Researcher Number	90261619
External Links
Affiliation (Current)	2022: 山形大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2010 – 2022: 山形大学, 医学部, 教授 2012: 弘前大学, 医学(系)研究科(研究院), 准教授 2010: 順天堂大学 2008 – 2010: 弘前大学, 医学研究科, 准教授 2007 – 2010: Hirosaki University, 大学院・医学研究科, 准教授 … More 2005 – 2006: 弘前大学, 医学部, 助教授 2003 – 2004: 弘前大学, 医学部附属病院, 講師 1999 – 2000: 東北大学, 医学部・附属病院, 助手 1996: 東北大学, 医学部・付属病院, 助手 1994: 東北大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Otorhinolaryngology / Surgery related to the biological and sensory functions and related fields / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Otorhinolaryngology / Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator 外有毛細胞 / prestin / 運動能 / 内耳 / キャパシタンス / 内耳再生 / 有毛細胞 / 再生 / パッチクランプ法 / 聴覚 … More / 聴神経 / シナプス / 神経 / ROCK阻害薬 / 蝸牛外有毛細胞 / ソノポレーション法 / コルチ器 / 細胞骨格 / 音響暴露 / 幹細胞 / 再生医学 / 再生医療 / シナプス再生 / cochlear synaptopathy / 鼻腺細胞 / アセチルコリン / イオン輸送 / マクロライド / 分泌 / 器官培養コルチ器 / 蝸牛増幅機構 / 遺伝子導入 / lipid raft / 脂質 / コレステロール / 翻訳後修飾機 / 細胞内シグナル伝達系 / Lipid raft / G蛋白 / 顔面神経麻痺 / ヒト皮膚線維芽細胞 / 機能再生 / ラット / 顔面神経損傷モデル / ヒト皮膚繊維芽細胞 / 神経再生 / Matrigel / 細胞長変化 / 原子間力顕微鏡 / stiffness / cochlear outer hair cell / cytoskeleton / electromotility / atomic force microscopy / 内耳障害 / 難聴 / 幹細胞移植 / 多能性幹細胞 / 内耳3次元器官培養 / 耳科学 / 感音難聴 / 聴覚再生 / 内有毛細胞 / 蝸牛神経 … More Except Principal Investigator 内耳 / 難聴 / 蝸牛 / 有毛細胞 / prestin / PCR-SSCP / CGH / FISH / 聴神経 / 鼻腺細胞 / 細胞内Ca^<2+> / パッチクランプ / イオン電流 / Na-K-Cl共輸送 / アセチルコリン / 遺伝子治療 / 細胞死 / apoptosis / caspase / aminoglycoside / 前庭 / 器官培養 / シナプス再形成 / 前庭神経節細胞 / 器官培養コルチ器 / 外有毛細胞 / 運動能 / 内耳外有毛細胞 / 蝸牛増幅機構 / パッチクランプ法 / siRNA / GJB2 / ノックアウトマウス / コルチ器 / 内リンパ / 半規管 / アデノウイルスベクター / アデノ随伴ウイルスベクター / 聴性脳幹反応 / GJB2遺伝子 / 遺伝子導入 / ウイルスベクター / アデノウイル / アデノ随伴ウイル / 聴覚障害 / 大規模調査 / アンチエイジング / 動脈硬化 / 遺伝子変異 / CGH法 / FISH法 / NF2 / 2ヒット / 聴神経腫瘍 / NF2 gene / 2 hit theory / 反回神経再生 / シナプス / cochlear synaptopaty / ROCK阻害薬 / hidden hearing loss / LISW / cochlear synaptopathy / 感音難聴 / 再生 / Cochlear synaptopathy / 顔面神経麻痺 / 神経栄養因子 / 内視鏡下耳科手術 / 内視鏡 / 内視鏡手術 / 神経再生術 Less

ROCK阻害薬を用いた反回神経再生の戦略的研究
- Principal Investigator
  
  倉上和也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yamagata University
感音難聴の新規病態に基づいた治療法の探索 -衝撃波による内耳障害モデルでの検討-
- Principal Investigator
  
  小泉優
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yamagata University
聴神経・シナプス再生の細胞内メカニズムの解明
- Principal Investigator
  
  天野彰子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yamagata University
IGF-1と徐放性製剤を組み合わせた内視鏡下顔面神経再生術
- Principal Investigator
  
  古川孝俊
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yamagata University
Cochlear synaptopathyに対する新規聴覚再生治療法の確立Principal Investigator
- Principal Investigator
  
  欠畑誠治
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Yamagata University
内有毛細胞・蝸牛神経間シナプスをターゲットとした聴覚再生治療の新規開発Principal Investigator
- Principal Investigator
  
  欠畑誠治
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Yamagata University
Challenge to development of new regenerative therapy targeting synapses between hair cells and auditory nerve fibersPrincipal Investigator
- Principal Investigator
  
  Kakehata Seiji
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Surgery related to the biological and sensory functions and related fields
- Research Institution
  Yamagata University
Multifaceted analysis of inner ear regeneration using Muse cellsPrincipal Investigator
- Principal Investigator
  
  kakehata seiji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Yamagata University
Challenges for effective delivery of stem cells to the organ of CortiPrincipal Investigator
- Principal Investigator
  
  Kakehata Seiji
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Yamagata University
Effect of transplanting normal human dermal fibroblasts (NHDF) in the rat facial nerve palsy modelPrincipal Investigator
- Principal Investigator
  
  KAKEHATA Seiji
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Yamagata University
Regulation of the OHC cytoskeleton induced by lipid raft.-Effects of cholesterol alterations on hearing-Principal Investigator
- Principal Investigator
  
  KAKEHTA Seiji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Yamagata University
Risk factors of associated with hearing impairment : an epidemiological study
- Principal Investigator
  
  SHINKAWA Hideichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Hirosaki University
Prestin翻訳後修飾機構の解明-OHC運動能自己修復による内耳再生への挑戦-Principal Investigator
- Principal Investigator
  
  欠畑誠治
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Hirosaki University
Cell therapy and gene therapy for heredity deafness with genetically modified mice
- Principal Investigator
  
  IKEDA Katuhisa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Juntendo University
Lipid raftはOHC情報伝達を調節する-運動能における脂質の機能解明-Principal Investigator
- Principal Investigator
  
  欠畑誠治
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Hirosaki University
Direct functional analysis of prestin transfected inner ear using invivo patch methodPrincipal Investigator
- Principal Investigator
  
  KAKEHATA Seiji
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Hirosaki University
intact OHCを用いたsiRNAによる至適prestin発現密度の直接解析
- Principal Investigator
  
  新川秀一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Hirosaki University
ソノポレーション法によるinvivoコルチ器へのprestin遺伝子導入Principal Investigator
- Principal Investigator
  
  欠畑誠治
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Hirosaki University
器官培養コルチ器を用いたprestinによる蝸牛増幅機構の直接的解析
- Principal Investigator
  
  新川秀一
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Hirosaki University
器官培養コルチ器へのprestin遺伝子(pres)導入-prestinによる蝸牛増幅機構の直接的解析-Principal Investigator
- Principal Investigator
  
  欠畑誠治
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Hirosaki University
前庭器官の器官培養技術を応用した有毛細胞、神経節細胞間シナプス再形成の試み
- Principal Investigator
  
  SHINKAWA Hideichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Hirosaki University
マウス胎仔内耳細胞の遺伝子改変技術の確立(先天性難聴の治療に向けて)
- Principal Investigator
  
  大島猛史
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tohoku University
Direct analysis of the variability of the particles located in the lateral membrane of the outer hair cells and transduction mechanism using atomic force microscopyPrincipal Investigator
- Principal Investigator
  
  KOIKE Takuji, 欠畑誠治
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tohoku University
Analysis of genes responsible for sporadic vestibular schwannomas
- Principal Investigator
  
  HASHIMOTO Sho
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tonoku University
ヒト培養鼻腺細胞の分泌,吸収のイオン輸送とその細胞内伝達機構Principal Investigator
- Principal Investigator
  
  欠畑誠治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tohoku University
鼻腺細胞の分泌機序に関する分子生理学的研究
- Principal Investigator
  
  IKEDA Katuhisa
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tohoku University

All 2022 2021 2020 2019 2018 2013 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] The feasibility and treatment results of transcanal endoscopic myringoplasty2022
- Author(s)
  Furukawa T, Ito T, Kubota T, Futai K, Matsui H, Kakehata S
- Journal Title
  
  Otol Neurotol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09624
[Journal Article] Benefits of High-Dose Corticosteroid and Antiviral Agent Combination Therapy in the Treatment of House-Brackman Grade VI Ramsay Hunt Syndrome2022
- Author(s)
  Furukawa T, Abe Y, Ito T, Kubota T, Hull M, Goto T, Sugiyama M, Kakehata S
- Journal Title
  
  Otol Neurotol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09624
[Journal Article] Consistent removal of hair cells in vestibular end organs by time-dependent transtympanic administration of gentamicin in guinea pigs2021
- Author(s)
  Chiba Makoto、Ito Tsukasa、Shinkawa Chikako、Koizumi Yutaka、Hull Melinda、Kakehata Seiji
- Journal Title
  
  Journal of Neuroscience Methods
  
  Volume: 351 Pages: 109049-109049
- DOI
  10.1016/j.jneumeth.2020.109049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16887, KAKENHI-PROJECT-20H03833
[Journal Article] Y-27632, a ROCK inhibitor, improved laser-induced shock wave (LISW)-induced cochlear synaptopathy in mice2021
- Author(s)
  Koizumi, Y., Mizutari, K., Kawauchi, S., Sato, S., Shiotani, A. & Kakehata
- Journal Title
  
  Molecular Brain
  
  Volume: 14 Pages: 105-105
- DOI
  10.1186/s13041-021-00819-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09335, KAKENHI-PROJECT-20H03833, KAKENHI-PROJECT-21K09555, KAKENHI-PROJECT-21K09573, KAKENHI-PROJECT-20KK0204
[Journal Article] Regenerative Effect of a ROCK Inhibitor, Y-27632, on Excitotoxic Trauma in an Organotypic Culture of the Cochlea2020
- Author(s)
  Koizumi Y, Ito T, Mizutari K, Kakehata S.
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 14 Pages: 572434-572434
- DOI
  10.3389/fncel.2020.572434
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09335, KAKENHI-PROJECT-20KK0204, KAKENHI-PROJECT-17K19713, KAKENHI-PROJECT-17K16887, KAKENHI-PROJECT-20H03833
[Journal Article] Expression and localization of diacylglycerol kinase ζ in guinea pig cochlea and its functional implication under noise-exposure stress conditions.2019
- Author(s)
  Shinkawa C, Ito T, Hozumi Y, Chiba M, Matsui H, Goto K, Kakehata S
- Journal Title
  
  Histochemistry and Cell Biology
  
  Volume: epub Pages: 461-474
- DOI
  10.1007/s00418-019-01781-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05479, KAKENHI-PROJECT-17K08507
[Journal Article] Effects of cholesterol alterations are mediated via G-protein-related pathways in outer hair cells2013
- Author(s)
  Nagaki T, Kakehata S, Kitani R, Abe T, Shinkawa H.
- Journal Title
  
  Pflugers Archiv -European Journal of Physiology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390315
[Journal Article] Hearing impairment and cognitive function among a community-dwelling population in Japan2011
- Author(s)
  N Sugawara, A Sasaki, N Yasui-Furukori, S Kakehata, T Umeda, A Namba, S Nakaji,H Shinkawa S Kaneko
- Journal Title
  
  Annals of General Psychiatry
  
  Volume: 10(1) Pages: 27-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591873
[Journal Article] Motile responses of cochlear outer hair cells stimulated with an alternating electrical field2011
- Author(s)
  Kitani R, Kakehata S, Kalinec F.
- Journal Title
  
  Hear Res
  
  Volume: 280(1-2) Pages: 209-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390315
[Journal Article] Motile responses of cochlear outer hair cells stimulated with an alternating electrical field2011
- Author(s)
  Kitani, Kakehata, Kalinec
- Journal Title
  
  Hearing Research
  
  Volume: 280 Pages: 209-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390315
[Journal Article] Hearing impairment and cognitive function among a community-dwelling population in Japan2011
- Author(s)
  N Sugawara, A Sasaki, N Yasui-Furukori, S Kakehata, T Umeda, A Namba, S Nakaji, H Shinkawa, S Kaneko
- Journal Title
  
  Annals of General Psychiatry
  
  Volume: 10 Pages: 27-27
- DOI
  10.1186/1744-859x-10-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591873
[Journal Article] Cochlear outer hair cells in a dominant-negative connexin26 mutant mouse preserve non-linear capacitance in spite of impaired distortion product otoacoustic emission.2009
- Author(s)
  Minekawa A, Abe T, Inoshita A, Iizuka T, Kakehata S, Narui Y, Koike T, Kamiya K, Okamura HO, Shinkawa H, Ikeda K
- Journal Title
  
  Neuroscience 164
  
  Pages: 1312-1319
- Data Source
  KAKENHI-PROJECT-20390445
[Journal Article] Cochlear outer hair cells in a dominant-negative connexin26 mutant mouse preserve non-linear capacitance in spite of impaired distortion product otoacoustic emission.2009
- Author(s)
  Minekawa A, Abe T, Inoshita A, Iizuka T, Kakehata S, Narui Y, Koike T, Kamiya K, Okamura HO, Shinkawa H, Ikeda K.
- Journal Title
  
  Neuroscience 164
  
  Pages: 1312-1319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390445
[Journal Article] Developmental expression of the outer hair cell motor, prest in, in the mouse.2007
- Author(s)
  Abe T, Kakehata S, et.al(corresponding author)
- Journal Title
  
  Journal of Membrane Biology 215
  
  Pages: 49-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390454
[Journal Article] (corresponding author) Developmental expression of the outer hair cell motor, prestin, in the mouse2007
- Author(s)
  Abe T, Kakehata S, Kitani R, Maruya SI, Navaratnam D, Santos-Sacchi J, Shinkawa H
- Journal Title
  
  J Membr Biol 215
  
  Pages: 49-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390454
[Journal Article] Tuning in to the amazing outer hair cell:membrane wizardry with a twist and shout.2007
- Author(s)
  He D, Zhen J, Kalinec F, Kakehata S. Santos-Sacchi J.
- Journal Title
  
  Journal of Membrane Biology 209
  
  Pages: 119-134
- Data Source
  KAKENHI-PROJECT-18390454
[Journal Article] Tuning in to the amazingouter hair cell : membrane wizardry with atwist and shout2006
- Author(s)
  He DZ, Zheng J, Kalinec F, Kakehata S, Santos-Sacchi J
- Journal Title
  
  J Membr Biol 209(2-3)
  
  Pages: 119-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390454
[Journal Article] CochlearOuter Hair Cells in a Dominant-NegativeConnexin26 Mutant Mouse Preserved Non-Linear Capacitance in spite ofImpaired Distortion Product OtoacousticEmission
- Author(s)
  Minekawa A, Abe T, Inoshita A, Iizuka T, Kakehata S, Narui Y, Koike T, Kamiya K, Okamura H, Shinkawa H, Ikeda K
- Journal Title
  
  Neuroscience (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390454
[Presentation] Advantages of using non-rigid registration of post-enhanced 3D-T1 Turbo Field Echo and CT images (TURFECT) in their Diagnosis and Surgical Treatment for Facial Nerve and Chorda Tympani Schwannomas2022
- Author(s)
  Furukawa T, Abe Y, Goto T, Sugiyama M, Amano A, Amano S, Godo S, Ito T, Inamura H, Kakehata S
- Organizer
  14th international facial nerve symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09624
[Presentation] Use of Basic Fibroblast Growth Factor to Treat Intractable Bell’s Palsy via Transcanal Endoscopic Ear Surgery2022
- Author(s)
  Furukawa T, Abe Y, Goto T, Sugiyama M, Amano A, Amano S, Godo S, Inamura H, Kakehata S
- Organizer
  14th international facial nerve symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09624
[Presentation] レチノイドを用いた中耳粘膜上皮の創傷治癒効果について2021
- Author(s)
  寺田小百合, 伊藤吏, 小泉優, 天野彰子, 新川智佳子, 欠畑誠治
- Organizer
  第31回日本耳科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-21K09555
[Presentation] Laser-induced shock waveによるcochlear synaptopathyモデルに対するROCK阻害薬の効果の検討2021
- Author(s)
  小泉優, 水足邦雄, 伊藤吏, 塩谷彰浩, 欠畑誠治
- Organizer
  第31回日本耳科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-20KK0204
[Presentation] 実験動物モデルにおける ABR を用いた伝音難聴と感音難聴の鑑別について2021
- Author(s)
  寺田小百合, 伊藤吏, 新川智佳子, 小泉優, 天野彰子, 松井祐興, 窪田俊憲, 欠畑誠治
- Organizer
  第１回 ERA・ERP 研究会
- Data Source
  KAKENHI-PROJECT-21K09555
[Presentation] Cochlear synaptopathy をターゲットとした治療法開発への試み～当科での内耳基礎研究について～2021
- Author(s)
  小泉優, 伊藤, 吏, 窪田俊憲, 松井祐興, 新川智佳子, 寺田小百合, 天野彰子, 欠畑誠治
- Organizer
  第６回耳鳴・難聴研究会
- Data Source
  KAKENHI-PROJECT-20KK0204
[Presentation] Laser-induced shock waveによるcochlear synaptopathyモデルに対するROCK阻害薬の効果の検討2021
- Author(s)
  小泉優, 水足邦雄, 伊藤吏, 塩谷彰浩, 欠畑誠治
- Organizer
  第31回日本耳科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-20H03833
[Presentation] Cochlear synaptopathy をターゲットとした治療法開発への試み～当科での内耳基礎研究について～2021
- Author(s)
  小泉優, 伊藤, 吏, 窪田俊憲, 松井祐興, 新川智佳子, 寺田小百合, 天野彰子, 欠畑誠治
- Organizer
  第６回耳鳴・難聴研究会
- Data Source
  KAKENHI-PROJECT-21K09555
[Presentation] 実験動物モデルにおける ABR を用いた伝音難聴と感音難聴の鑑別について2021
- Author(s)
  寺田小百合, 伊藤吏, 新川智佳子, 小泉優, 天野彰子, 松井祐興, 窪田俊憲, 欠畑誠治
- Organizer
  第１回 ERA・ERP 研究会
- Data Source
  KAKENHI-PROJECT-20KK0204
[Presentation] Cochlear synaptopathy をターゲットとした治療法開発への試み～当科での内耳基礎研究について～2021
- Author(s)
  小泉優 , 伊藤 , 吏 , 窪田俊憲 , 松井祐興 , 新川智佳子 , 寺田小百合 , 天野彰子 , 欠畑誠治
- Organizer
  第６回耳鳴・難聴研究会
- Data Source
  KAKENHI-PROJECT-20H03833
[Presentation] 実験動物モデルにおける ABR を用いた伝音難聴と感音難聴の鑑別について2021
- Author(s)
  寺田小百合 , 伊藤吏 , 新川智佳子 , 小泉優 , 天野彰子 , 松井祐興 , 窪田俊憲 , 欠畑誠治
- Organizer
  第１回 ERA・ERP 研究会
- Data Source
  KAKENHI-PROJECT-20H03833
[Presentation] Regenerative effects of a ROCK inhibitor, Y-27632, on facial nerve function and afferent cochlear synapses2021
- Author(s)
  Seiji Kakehata
- Organizer
  Korean Otological Society Annual Spring Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03833
[Presentation] Laser-induced shock waveによるcochlear synaptopathyモデルに対するROCK阻害薬の効果の検討2021
- Author(s)
  小泉優, 水足邦雄, 伊藤吏, 塩谷彰浩, 欠畑誠治
- Organizer
  第31回日本耳科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-21K09555
[Presentation] レチノイドを用いた中耳粘膜上皮の創傷治癒効果について2021
- Author(s)
  寺田小百合, 伊藤吏, 小泉優, 天野彰子, 新川智佳子, 欠畑誠治
- Organizer
  第31回日本耳科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-20KK0204
[Presentation] Regenerative effects of a ROCK inhibitor, Y-27632, on facial nerve function and afferent cochlear synapses2021
- Author(s)
  Seiji Kakehata
- Organizer
  Korean Otological Society Annual Spring Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0204
[Presentation] レチノイドを用いた中耳粘膜上皮の創傷治癒効果について2021
- Author(s)
  寺田小百合, 伊藤吏, 小泉優, 天野彰子, 新川智佳子, 欠畑誠治
- Organizer
  第31回日本耳科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-20H03833
[Presentation] ROCK inhibitor Y-27632 accelerates auditory nerve fiber growth and synapse formation after excitotoxic trauma in organotypic culture of cochlea2019
- Author(s)
  Yutaka Koizumi, Tsukasa Ito, Seiji Kakehata
- Organizer
  Association for Research in Otolaryngology 42nd Annual MidWinter Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05479
[Presentation] 蝸牛器官培養聴神経障害モデルにおけるROCK阻害薬の効果の検討2019
- Author(s)
  小泉優, 伊藤吏, 欠畑誠治
- Organizer
  日本耳科学会
- Data Source
  KAKENHI-PROJECT-17K19713
[Presentation] 蝸牛器官培養聴神経障害モデルを用いた聴神経の再生2019
- Author(s)
  小泉優, 伊藤吏, 欠畑誠治
- Organizer
  日本耳鼻咽喉科学会東北地方連合学術講演会
- Data Source
  KAKENHI-PROJECT-17K19713
[Presentation] 蝸牛器官培養聴神経障害モデルを用いた聴神経の再生2018
- Author(s)
  小泉優, 伊藤吏, 欠畑誠治
- Organizer
  日本耳科学会
- Data Source
  KAKENHI-PROJECT-16H05479
[Presentation] 難聴と認知機能低下の関連性岩木健康増進プロジェクトにおける一般地域住民での検討2011
- Author(s)
  佐々木亮、欠畑誠治、南場淳司、新川秀一
- Organizer
  第56回日本聴覚医学会
- Place of Presentation
  福岡市
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-22591873
[Presentation] 難聴と認知機能低下の関連性岩木健康増進プロジェクトにおける一般地域住民での検討2011
- Author(s)
  佐々木亮, 欠畑誠治, 南場淳司, 新川秀一
- Organizer
  第56回日本聴覚医学会
- Place of Presentation
  福岡市
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-22591873
[Presentation] 蝸牛外有毛細胞膜の脂質はG蛋白を介した細胞内シグナル伝達系により細胞骨格を制御する2010
- Author(s)
  長岐孝彦、欠畑誠治
- Organizer
  第20回日本耳科学会
- Place of Presentation
  ひめぎんホール(松山市)
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-21659388
[Presentation] Cholesterol of Outer Hair Cell Membrane Controls Cytoskeleton via G Protein Related Pathway2010
- Author(s)
  Nagaki T, Kakehata S
- Organizer
  Sixth International Symposium on Meniere' s Disease and Inner Ear Disorders
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-21659388
[Presentation] 蝸牛外有毛細胞運動能に対する脂質を介した細胞内シグナル伝達系の効果2010
- Author(s)
  長岐孝彦、欠畑誠治
- Organizer
  第59回日本耳鼻咽喉科学会東北地方部会連合学術講演会
- Place of Presentation
  秋田キャッスルホテル(秋田市)
- Year and Date
  2010-07-24
- Data Source
  KAKENHI-PROJECT-21659388
[Presentation] 骨密度と聴力との関連-岩木健康増進プロジェクトにおける検討-2010
- Author(s)
  佐々木亮, 欠畑誠治, 南場淳司, 新川秀一
- Organizer
  第111回日本耳鼻咽喉科学会総会
- Place of Presentation
  仙台市
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-22591873
[Presentation] Developmental Expression of the Outer Hair Cell Capacit ance in a Dominant-Negative Connexin26 Mutant Mouse2009
- Author(s)
  Abe T, Kakehata S, et.al.
- Organizer
  32nd MidWinter Meeting of Association for Research in Otolaryngology
- Place of Presentation
  Baltimore, MD, USA
- Data Source
  KAKENHI-PROJECT-18390454
[Presentation] CochlearOuter Hair Cells in a Dominant-Negative Connexin26 Mutant Mouse PreservedNon-Linear Capacitance in spite ofImpaired Distortion Product OtoacousticEmission.2009
- Author(s)
  Minekawa A, Abe T, Inoshita A, Iizuka T,Kakehata S, Narui Y, Koike T, Kamiya K, Okamura H, Shinkawa H, Ikeda K
- Organizer
  32nd MidWinter Meeting ofAssociation for Research in Otolaryngology
- Place of Presentation
  Baltimore, MD, USA
- Data Source
  KAKENHI-PROJECT-18390454
[Presentation] Cochlear Outer Hair Cells in a Dominant-Negative Connexin26 Mutant Mouse Preserved Non-Linear Capacitance with Impaired Distortion Product Otoacoustic Emission2009
- Author(s)
  Abe T, Kakehata S, et.al.
- Organizer
  32nd MidWinter Meeting of Association for Research in Otolaryngology
- Place of Presentation
  Baltimore, MD, USA
- Data Source
  KAKENHI-PROJECT-18390454
[Presentation] DevelopmentalExpression of the Outer Hair CellCapacitance in a Dominant-NegativeConnexin26 Mutant Mouse. 32nd MidWinterMeeting of Association for2009
- Author(s)
  Abe T, Kakehata S, et.al.
- Organizer
  Research in Otolaryngology
- Place of Presentation
  Baltimore, MD, USA
- Data Source
  KAKENHI-PROJECT-18390454
[Presentation] MODIFICATION OF MEMBRANE LIPID ALTERS OUTER HAIR CELLELECTROMOTILITY AND CAPACITANCE2008
- Author(s)
  Kitani R, Kakehata S, et.al.
- Organizer
  45th Inner Ear Biology Workshop
- Place of Presentation
  Ferrara, Italy
- Data Source
  KAKENHI-PROJECT-19659432
[Presentation] Gjb2変異マウスにおける蝸牛外有毛細胞の運動能の解析2008
- Author(s)
  阿部尚央、欠畑誠治, 他
- Organizer
  第18回日本耳科学会総会学術講演会
- Place of Presentation
  神戸
- Year and Date
  2008-10-16
- Data Source
  KAKENHI-PROJECT-18390454
[Presentation] DirectEffects of Cholesterol and Mβcd On OuterHair Cell Motility and Capacitance2008
- Author(s)
  Kitani R, Kakehata S, Murakoshi M, WadaH, Maruya S, Abe T, Shinkawa H
- Organizer
  31st MidWinter Meeting of Association for Research in Otolaryngology
- Place of Presentation
  Phoenix, Arizona, USA
- Data Source
  KAKENHI-PROJECT-18390454
[Presentation] The Direct Effects of Cholesterol and Mβcd On Outer Hair Cell Motility and Capacitance2008
- Author(s)
  Kitani R, Kakehata S, et. al.
- Organizer
  31st MidWinter Meeting of Association for Research in Otolaryngology
- Place of Presentation
  Phoenix, AZ, USA
- Data Source
  KAKENHI-PROJECT-19659432
[Presentation] 幼若期のGjb2変異マウスの歪耳音響放射の測定および外有毛細胞の機能評価について2008
- Author(s)
  峯川、阿部尚央、欠畑誠治, 他
- Organizer
  第18回日本耳科学会総会学術講演会
- Place of Presentation
  神戸
- Year and Date
  2008-10-16
- Data Source
  KAKENHI-PROJECT-18390454
[Presentation] The effects ofcholesterol on outer hair cell motility2006
- Author(s)
  Kitani R, Kakehata S, Murakoshi M, Wada H, Abe T, Shinkawa H
- Organizer
  INNER EAR BIOLOGY Workshop
- Place of Presentation
  Montpellier, France
- Data Source
  KAKENHI-PROJECT-18390454
[Presentation] The direct effects ofcholesterol on outer hair cell motility2006
- Author(s)
  Kitani R, Kakehata S, Murakoshi M, WadaH, Shinkawa H
- Organizer
  The 2nd Shanghai International Conference on Physiological Biophysics-Audition andVision
- Place of Presentation
  Shanghai, China
- Data Source
  KAKENHI-PROJECT-18390454

1. MARUYA Shin-ichiro (90396408)

# of Collaborated Projects: 6 results

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2. ITO Tsukasa (50344809)

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# of Collaborated Products: 11 results
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# of Collaborated Projects: 5 results

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17. 寺田小百合 (40795697)

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18. KITANI Rei (80436047)

# of Collaborated Projects: 1 results

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19. MINOWA Osamu (00181967)

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20. TAKESHI Kusunoki (30248025)

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21. FURUKAWA Masayuki (20359524)

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22. YOKOI Hidenori (80317487)

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23. KAMIYA Kazusaku (10374159)

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24. MURAKOSHI Michio (70570901)

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25. SASAKI Akira (20451479)

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26. NAKAJI Shigeyuki (10192220)

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27. HASHIMOTO Sho (20156285)

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Kakehata Seiji 欠畑 誠治

KAKEHATA Seiji 欠畑 誠治

欠畑 誠治 カケハタ セイジ

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Cochlear synaptopathyに対する新規聴覚再生治療法の確立Principal Investigator

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内有毛細胞・蝸牛神経間シナプスをターゲットとした聴覚再生治療の新規開発Principal Investigator

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Challenge to development of new regenerative therapy targeting synapses between hair cells and auditory nerve fibersPrincipal Investigator

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Multifaceted analysis of inner ear regeneration using Muse cellsPrincipal Investigator

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Challenges for effective delivery of stem cells to the organ of CortiPrincipal Investigator

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Effect of transplanting normal human dermal fibroblasts (NHDF) in the rat facial nerve palsy modelPrincipal Investigator

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Regulation of the OHC cytoskeleton induced by lipid raft.-Effects of cholesterol alterations on hearing-Principal Investigator

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Prestin翻訳後修飾機構の解明-OHC運動能自己修復による内耳再生への挑戦-Principal Investigator

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Kakehata Seiji 欠畑誠治

KAKEHATA Seiji 欠畑誠治

欠畑誠治カケハタセイジ