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naraba hiroaki  奈良場 博昭

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NARABA HIROAKI  奈良場 博昭

NARABA Hiroaki  奈良場 博昭

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Researcher Number 90296517
Affiliation (Current) 2025: 岩手医科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2017 – 2019: 岩手医科大学, 薬学部, 教授
2008 – 2010: Iwate Medical University, 薬学部, 准教授
2005 – 2006: 岩手医科大学, 医学部, 助教授
2004: 国立循環器病センター研究所, 疫学部, 室長
2001 – 2003: 国立循環器病センター研究所, 薬理部, 室員
2001: National Cardiovascular Center, 薬理部, 研究員
1998 – 2000: 北里大学, 薬学部, 助手
Review Section/Research Field
Principal Investigator
General pharmacology / 応用薬理学・医療系薬学 / Biology of Cells to Organisms, and related fields
Except Principal Investigator
応用薬理学・医療系薬学 / General medical chemistry / Biological pharmacy
Keywords
Principal Investigator
プロスタグランジン / 炎症 / シクロオキシゲナーゼ / 初期応答遺伝子 / 転写調節因子 / ブラジキニン / マイクロRNA / 慢性関節リウマチ / エクソソーム / 転写制御 … More / 癌 / 血管新生 / 新生血管 / 炎症性病態 / 転写調節 / 遺伝子発現 / マイクロアレイ / マクロファージ / エンドトキシン / 炎症性疾患 / noncoding RNA / microRNA / 関節リウマチ / 疼痛 / PGE2 / プロスタグランジ / サイトカイン / Cキナーゼ / 血管内皮細胞 / AP-1 / MAPキナーゼ / B1受容体 … More
Except Principal Investigator
炎症 / PGE2 / PPAR-delta / Hsp90 / Cyclooxygenase / arteriosclerosis / kidney / vascular endothelial cells / knockout mice / prostacyclin synthase / prostaglandin / prostacyclin / 血管 / Egr-1 / プロスタグランジンE合成酵素(6) / PPARδ / プロスタサイクリン合成酵素(3) / サイトカイン / 動脈硬化 / 腎臓 / 血管内皮細胞 / ノックアウトマウス / プロスタサイクリン合成酵素 / プロスタグランジン / プロスタサイクリン / Inflamamtory / Arachidonic acid / Colon tumors / PGE_2 synthase / PGE_2 / アラキドン酸代謝 / 大腸癌 / シクロオキシゲナーゼ / PGE2合成酵素 / RECEPTORS / ANTAGONIST / INFLAMMATION / BRADYKININ / アンタゴニスト / 受容体 / アンタボンスト / ブラジキニン / Macrophages / Inducible enzyme / PDE synthase / Prostaglandins / Arachidonate Metabolites / リポポリサッカライド / トロンボキサンB_2 / プロスタグランジンD_2 / プロスタグランジンE_2 / シクロオキシゲナーゼ-2 / シクロオキシゲナーゼ-1 / ホスホリパーゼA_2 / PGI_2 / マクロファージ / エンドトキシン / PGI2 / PGE合成酵素 / COX-2 / アラキドン酸 Less
  • Research Projects

    (10 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (12 People)
  •  Role of exosomes as secretory vesicles in the pathophysiology of rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      NARABA HIROAKI
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Biology of Cells to Organisms, and related fields
    • Research Institution
      Iwate Medical University
  •  Involvement of membrane-associated prostaglandin E synthase-1 in neovascularization.Principal Investigator

    • Principal Investigator
      NARABA Hiroaki
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Iwate Medical University
  •  NoncodingRNAによるプロスタグランジン合成酵素の発現制御機構の解析Principal Investigator

    • Principal Investigator
      奈良場 博昭
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General pharmacology
    • Research Institution
      Iwate Medical University
  •  プロスタグランジンE2合成酵素の転写調節機構の解明とその制御法の開発Principal Investigator

    • Principal Investigator
      奈良場 博昭
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General pharmacology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Studies onfanction of prostacyclin and thromboxane in vascular disorders

    • Principal Investigator
      YOKOYAMA Chieko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  プロスタグランジンE_2産生におけるブラジキニンB1受容体の役割Principal Investigator

    • Principal Investigator
      奈良場 博昭
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Analysis of prostaglandin E2 synthases

    • Principal Investigator
      KUDO Ichiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Showa University
  •  ブラジキニンB1,B2受容体の発現とその機能解析Principal Investigator

    • Principal Investigator
      奈良場 博昭
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kitasato University
  •  THE RESEARCH FOR THE ROLES OF BRADYKININ RECEPTORS IN THE INFLAMMATORY RESPONSE

    • Principal Investigator
      UENO Akinori
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      KITASATO UNIVERSITY
  •  Functional coupling of arachidonate metabolizing enzymes

    • Principal Investigator
      OH-ISHI Sachiko
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kitasato University

All 2019 2018 2010 2008 2006 2005 2004

All Journal Article Presentation

  • [Journal Article] DNA damage-induced modulation of GLUT3 expression is mediated through p53-independent extracellular signal-regulated kinase signaling in HeLa cells.2010

    • Author(s)
      Watanabe M, Naraba H, Sakyo T, Kitagawa T.
    • Journal Title

      Mol Cancer Res. 8(11)

      Pages: 1547-1557

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590259
  • [Journal Article] Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy.2008

    • Author(s)
      Yuhki K, Ushikubi F, Naraba H, Ueno A, Kato H, Kojima F, Narumiya S, Sugimoto Y, Matsushita M, Oh-Ishi S.
    • Journal Title

      J Pharmacol Exp Ther. 325(2)

      Pages: 601-609

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590259
  • [Journal Article] MicroRNA and 3T3-L1 pre-adipocyte differentiation.2006

    • Author(s)
      Kajimoto K, Naraba H, Iwai N
    • Journal Title

      RNA 12・9

      Pages: 1626-1632

    • Data Source
      KAKENHI-PROJECT-17790177
  • [Journal Article] Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita Study2005

    • Author(s)
      Kokubo Y, Iwai N, Tago N, Inamoto N, Okayama A, Yamawaki H, Naraba H, Tomoike H
    • Journal Title

      Circ J. 69・2

      Pages: 1218-1224

    • NAID

      110002696060

    • Data Source
      KAKENHI-PROJECT-17790177
  • [Journal Article] Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat2005

    • Author(s)
      Iwai N, Yasui N, Naraba H, Tago N, Yamawaki H, Sumiya H
    • Journal Title

      Hypertension 45・5

      Pages: 947-953

    • Data Source
      KAKENHI-PROJECT-17790177
  • [Journal Article] Functional confirmation of Gitelman's syndrome mutations in Japanese2005

    • Author(s)
      Naraba H, Kokubo Y, Tomoike H, Iwai N
    • Journal Title

      Hypertens Res. 28・10

      Pages: 805-809

    • NAID

      10018367130

    • Data Source
      KAKENHI-PROJECT-17790177
  • [Journal Article] Assessment of the microRNA system in salt-sensitive hypertension2005

    • Author(s)
      Naraba H, Iwai N
    • Journal Title

      Hypertens Res. 28・10

      Pages: 819-826

    • NAID

      10018367175

    • Data Source
      KAKENHI-PROJECT-17790177
  • [Journal Article] Polymorphisms in human pre-miRNAs2005

    • Author(s)
      Iwai N, Naraba H
    • Journal Title

      Biochem Biophys Res Commun 331・4

      Pages: 1439-1444

    • Data Source
      KAKENHI-PROJECT-17790177
  • [Journal Article] Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis.2004

    • Author(s)
      Kojima F, Naraba H, Miyamoto S, Beppu M, Aoki H, Kawai S.
    • Journal Title

      Arthritis Res Ther. 6(4)

    • Data Source
      KAKENHI-PROJECT-15790142
  • [Journal Article] A promoter variant of the ATP-binding cassette transporter A1 gene alters the HDL cholesterol level in the general Japanese population.2004

    • Author(s)
      Shioji K, Nishioka J, Naraba H, Kokubo Y, Mannami T, Iwai N. et al.
    • Journal Title

      J Hum Genet. 49(3)

      Pages: 141-147

    • NAID

      10012891138

    • Data Source
      KAKENHI-PROJECT-15790142
  • [Journal Article] Prostaglandin receptors EP2, EP3, and IP mediate exudate formation in carrageenin-induced mouse pleurisy.2004

    • Author(s)
      Yuhki K, Ueno A, Naraba H, Kojima F, Ushikubi F, Narumiya S, Oh-ishi S.
    • Journal Title

      J Pharmacol Exp Ther. 311(3)

      Pages: 1218-1224

    • Data Source
      KAKENHI-PROJECT-15790142
  • [Journal Article] Association analysis between hypertension and CYBA, CLCNKB, and KCNMBI functional polymorphisms in the Japanese population--the Suita Study.2004

    • Author(s)
      Kokubo Y, Iwai N, Tago N, Inamoto N, Okayama A, Yamawaki H, Naraba H, Tomoike H.
    • Journal Title

      Circ J. 69(2)

      Pages: 138-142

    • Data Source
      KAKENHI-PROJECT-15790142
  • [Journal Article] A high prevalence of Gitelman's syndrome mutations in Japanese.2004

    • Author(s)
      Tago N, Kokubo Y, Inamoto N, Naraba H, Tomoike H, Iwai N.
    • Journal Title

      Hypertens Res. 27(5)

      Pages: 327-331

    • NAID

      10013603834

    • Data Source
      KAKENHI-PROJECT-15790142
  • [Presentation] 慢性関節リウマチモデルマウスの血中エクソソームにおける低分子RNAと病態の関係2019

    • Author(s)
      奈良場博昭、青山玲子
    • Organizer
      第40回日本炎症・再生医学会
    • Data Source
      KAKENHI-PROJECT-17K19405
  • [Presentation] 関節リウマチの炎症症状とエクソソーム由来マイクロRNAの発現変動の検討2019

    • Author(s)
      岩花諒、青山玲子、奈良場博昭
    • Organizer
      第58回日本薬学会東北支部会
    • Data Source
      KAKENHI-PROJECT-17K19405
  • [Presentation] 慢性関節リウマチモデルマウスの血中エクソソームにおける低分子RNAと病態の関係2018

    • Author(s)
      奈良場博昭
    • Organizer
      日本炎症再生医学会
    • Data Source
      KAKENHI-PROJECT-17K19405
  • 1.  UENO Akinori (00112657)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  KUDO Ichiro (30134612)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  MURAKAMI Makoto (60276607)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  IKEDA Yuri (10306657)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  OH-ISHI Sachiko (70050416)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  NAKATANI Yoshihito (80266163)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  YOKOYAMA Chieko (90200914)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  TOSHIHISA Hatae (10251026)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  宇都宮 郁 (70168722)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  奈良場 博昭 (13771443)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KAMIMURA Takashi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  SUGIMOTO Masamichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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