• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Noshiro Hirokazu  能城 浩和

ORCIDConnect your ORCID iD *help
… Alternative Names

NOSHIRO Hirokazu  能城 浩和

Less
Researcher Number 90301340
Other IDs
Affiliation (Current) 2025: 佐賀大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2017 – 2024: 佐賀大学, 医学部, 教授
2007: Kyushu University, Faculty of Medical Sciences, Contracted Research Associate
2006: 九州大学, 大学院医学研究院, 非常勤講師
2005: Kyushu University, Faculty of Medical Sciences, Contracted Research Assosiate, 大学院・医学研究院, 共同研究員
2003 – 2004: Faculty of Medicine University Hospital, Ass., 大学病院, 助手 … More
2002: 九州大学, 医学部附属病院, 助手
2000 – 2001: 九州大学, 医学部・附属病院, 助手
1998 – 1999: 九州大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Digestive surgery / Basic Section 55020:Digestive surgery-related / Digestive surgery / General surgery
Except Principal Investigator
Basic Section 55020:Digestive surgery-related / Digestive surgery / Basic Section 49020:Human pathology-related
Keywords
Principal Investigator
胃癌 / 低重力培養 / IFN-γ / TGF-β / tumor marker / gastric cancer / 腫瘍マーカー / 硫黄呼吸 / HIF-1a / 食道扁平上皮癌 … More / ファルネシル転換酵素 / 悪液質 / 炎症性サイトカイン / ファルネシル転換酵素阻害薬 / ファルネシル化 / 癌悪液質 / 脂肪酸代謝 / Warburg効果 / 癌 / カルニチン / パルミチン酸 / YC-1 / 低酸素環境 / 脂肪酸合成 / 活性酸素 / HIF-1α / Theranv for colorectal cancer / Glil mRNA / Morphogenesis signaling Pathways / Hedgehog signaling pathway / Wnt signaling pathway / Colorectal cancer / シグナルクロストーク / Glil遺伝子 / 大腸がん治療 / Gli1遺伝子 / 形態形成シグナル / Hedgehogシグナル / Wntシグナル / 大腸がん / simulated microgravity culture / cancer-specific / histoculture drug response assay / carcinoma tissue / 消化器癌 / 組織感受性試験 / 疑似低重力培養 / 癌特異的 / 組織薬剤感受性試験 / 癌組織 / artificial tissue / pancreas cancer / invasion / 3-dimension / microgravity / IFN-g / TGF-b / 三次元培養 / 人工癌組織 / SMAD / スキルス / 人工がん組織 / 転移 / 人工臓器 / 膵癌 / 浸潤 / 3次元培養 / 低重力 / esophageal cancer / pathological examination / cancer-related factors / 早期癌 / 遺伝子 / 腫瘍増殖関連遺子 / 食道癌 / 病理組織検査 / 腫瘍増殖関連遺伝子 / HGF / 8-oxo-dGTP / 胆管癌 / 胆石症 / 肝内結石症 … More
Except Principal Investigator
bile acid synthesis / 胆汁酸合成 / 手術支援システム / 結合組織 / ロボット支援手術 / 手術支援 / 深層学習 / 人工知能 / 活性酸素 / rat / regulation mechanism / bile acid metabolism / ラット / 調節機構 / 胆汁酸代謝 / 腸管因子 / 7αヒドロキシコレステロール / 膵臓 / コンピュータビジョン / ファルネシル転換酵素 / 食道癌 / 上皮間葉転換 / 低酸素誘導因子 / ファルネシル転換酵素阻害薬 / ファルネシル化 / 食道扁平上皮癌 / 膵 / 解剖学的ランドマーク / 画像セグメンテーション / 抗ウイルス剤 / Sustained Viral Response / Direct acting Antivirals / 肝細胞癌 / CD8 / 免疫微小環境 / 肝炎ウイルス / 肝癌 / 胃癌 / 低酸素環境 / ミトコンドリア休眠 / Mieap / 低酸素 / 癌浸潤 / hypoxia / MMP-1 / MALM / mieap / ROS / HIF-1 / intestinal factor / cholesterol 7α-hydroxylase / コレステロール7α酸化酵素 / コレステロール7α水酸化酵素 / intestinal facor / 7α-hydroxycholesterol / cholestyramine / liver regeneration / hepatectomy / hepatic functional reserve / 7α -hydroxycholesterol / 肝切除 / 負荷試験 / コレスチラミン / 肝予備能 Less
  • Research Projects

    (16 results)
  • Research Products

    (5 results)
  • Co-Researchers

    (34 People)
  •  A novel therapeutic strategy for hypoxic esophageal squamous cell carcinoma targeting HIF-1a and sulfur respirationPrincipal Investigator

    • Principal Investigator
      能城 浩和
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Saga University
  •  食道扁平上皮癌に対する蛋白ファルネシル化に着目した新規治療開発に向けた基礎的研究

    • Principal Investigator
      田中 智和
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Saga University
  •  コンピュータビジョンを用いた外科医の意思決定支援システムの実用化に向けた開発研究

    • Principal Investigator
      篠原 尚
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Hyogo Medical University
  •  Basic research for development of new treatment for cachexia by gastric cancer focusing on protein farnesylationPrincipal Investigator

    • Principal Investigator
      Noshiro Hirokazu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Saga University
  •  Pathological investigation of microenvironment in the liver cancer treated by direct anti-viral drugs

    • Principal Investigator
      Aishima Shinichi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Saga University
  •  Development of real-time surgery support system using deep learning by artificial intelligence

    • Principal Investigator
      Shinohara Hisashi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Hyogo Medical University
  •  Impaired hypoxia-induced mitochondrial sleep may increase malignant behavior of gastric cancer cells

    • Principal Investigator
      Kitajima Yoshihiko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Saga University
  •  Basic research of novel therapeutic strategy focusing on fatty acid metabolism alteration of gastric cancer cells under hypoxiaPrincipal Investigator

    • Principal Investigator
      Noshiro Hirokazu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Saga University
  •  Development of therapeutic strategy for colorectal cancer by utilizing cross-talk between morphogenesis-related signaling pathwaysPrincipal Investigator

    • Principal Investigator
      NOSHIRO Hirokazu
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Development of a cancer-specific histoculture drug response assay with a simulated microgravity culture systemPrincipal Investigator

    • Principal Investigator
      NOSHIRO Hirokazu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      KYUSHU UNIVERSITY
  •  Development of artificial 3-dimensional cancer tissue model as tool for pathological analysis and therapeutic research for malignant solid tumorPrincipal Investigator

    • Principal Investigator
      NOSHIRO Hirokazu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      KYUSHU UNIVERSITY
  •  Molecular biological mechanism for regulation of bile acid synthesis can explain bile acid synthesis under interrupted enterohepatic circulation in vivo?

    • Principal Investigator
      KUROKI Syoji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Clinical utilization of profiles of cancer-related factors in gastric and esophageal cancerPrincipal Investigator

    • Principal Investigator
      NOSHIRO Hirokazu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      KYUSHU UNIVERSITY
  •  Investigation on the intestinal factor(s) of regulational mechanism of bile acid synthesis

    • Principal Investigator
      KUROKI Shoji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      KYUSHU UNIVERSITY
  •  動物モデルを用いた肝内結石症に対する成因論の解明と発癌に関する実験的研究Principal Investigator

    • Principal Investigator
      能城 浩和
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Clinical significance of serum 7α-hydroxycholesterol level and hepatic functional reserve in patients who undergo partial hepatectomy

    • Principal Investigator
      KUROKI Syoji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University

All 2023 2022 2020 2019 Other

All Journal Article Presentation

  • [Journal Article] Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation2019

    • Author(s)
      Okuyama Keiichiro、Kitajima Yoshihiko、Egawa Noriyuki、Kitagawa Hiroshi、Ito Kotaro、Aishima Shinichi、Yanagihara Kazuyoshi、Tanaka Tomokazu、Noshiro Hirokazu
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41598-019-39563-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08650
  • [Journal Article] Crosstalk of Hedgehog and Wnt signaling pathways in gastric cancer

    • Author(s)
      Yanai, K, Nakamura, M, Akiyoshi, T, Nagai, S, Wada, J, Koga, K, Noshiro, H, Nagai, E, Tsuneyoshi, M, Tanaka, M, Katano, M
    • Journal Title

      Cancer Lett (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591468
  • [Presentation] Antitumor effects by suppression of HIF-1α and EMT of farnesyl transferase inhibitor in esophageal cancer cells2023

    • Author(s)
      Kazuki Higure, Tomokazu Tanaka, Naoya Kimura, Shohei Matsufuji, Hirokazu Noshiro
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-22K08778
  • [Presentation] Antitumor effects of Farnesyl transferase inhibitor in Esophageal cancer cells2022

    • Author(s)
      Shohei Matsufuji, Tomokazu Tanaka, Naoya Kimura, Kazuki Higure, Hirokazu Noshiro
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-22K08778
  • [Presentation] 画像セグメンテーションによる微細解剖構造認識;ロボット支援下胃癌手術における疎性結合組織間隙の可視化2020

    • Author(s)
      篠原尚,小林 直, 熊頭 勇太, ラヤン エルーシュ, ポール ネクロユ, 石田 善敬, 金谷 誠一郎, 能城 浩和, 宇山 一朗, 北村 尚紀.
    • Organizer
      第75回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-19H03735
  • 1.  田中 智和 (60781903)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 3 results
  • 2.  KUROKI Syoji (30215090)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  CHIJIIWA Kazuo (90179945)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  SHIMIZU Shuji (70274454)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  KATANO Mitsuo (10145203)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  KOJIMA Masayuki (90380394)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  YAMAGUCHI Koji (50191226)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  UCHIYAMA Akihiko (20294936)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  MORISAKI Takashi (90291517)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  NAKANO Kenji (00315061)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  SUEISHI Katsuo (70108710)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  Kitajima Yoshihiko (30234256)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 13.  Shinohara Hisashi (70319549)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 14.  倉橋 康典 (10834822)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  宇山 一朗 (60193950)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 16.  池田 正孝 (80335356)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  石田 善敬 (80447664)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 18.  大森 健 (40423181)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 19.  MATSUDA Takehisa (60142189)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  OHSHIMA Akira (70335959)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  NAKAMURA Masafumi (30372741)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  TANAKA Masao (30163570)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  KUBO Makoto (60403961)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  MIBU Ryuichi (20200107)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  UEKI Takashi (30274468)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  Aishima Shinichi (70346774)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  吉田 裕樹 (40260715)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  平岡 伸介 (40276217)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  杉町 圭史 (90452763)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  隈本 力 (90834820)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  芥川 剛至 (40839057)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  伊藤 孝太朗 (80920967)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  甲斐 敬太 (60516540)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  中村 達郎 (20898457)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi